JP7374755B2 - Skin external composition - Google Patents

Description

The present invention relates to a composition for external use on the skin that improves the firmness and elasticity of the skin, has an excellent feel when used without stickiness, has an excellent effect of suppressing crystal precipitation, and is less likely to suffer from poor stability such as odor caused by oxidation.

In recent years, many basic cosmetics have been released that aim to improve age spots, wrinkles, sagging, pigmentation, etc. caused by aging, stress, ultraviolet rays, dry air, etc. In particular, it is desirable to improve wrinkles and sagging skin as they give the impression of advanced aging. By incorporating nicotinic acid amide as an effective ingredient, it has the effect of improving rough skin and keratin. Furthermore, it is highly safe even when blended in high amounts, and can improve skin firmness and elasticity (Patent Document 1).

However, it is known that adding a large amount of nicotinic acid amide causes stickiness and squeaking, making it difficult to obtain a good feel when using the product (Patent Document 2). In the case of external skin compositions, it is known that nicotinic acid amide crystals precipitate when the contents dry after adhering to the mouth or cap, or when adhering to the side of the container (Patent Document 3).

On the other hand, in Patent Document 2, stickiness when a large amount of nicotinic acid amide is blended is reduced by using a specific branched chain hydrocarbon or a specific highly malleable oil. However, if the contents adhere to the mouth or cap, crystals may precipitate and prevent the container from opening and closing smoothly.
Another solution is to use an ester of linear fatty acid and polyethylene glycol as an emulsifier in an oil-in-water emulsion composition, and add vaseline to the composition, even if more than 1% nicotinamide is added. It has been reported that an oil-in-water emulsion composition can be obtained that has no irritation or stickiness, has an excellent feel in use, and has an excellent crystallization suppressing effect (Patent Document 4).
However, although Patent Document 4 provides a composition for external use on the skin that is overall good, it is limited to an oil-in-water emulsion that essentially contains petrolatum, and it cannot be said that it has sufficient versatility.
In Patent Document 3, crystal precipitation is improved by blending a specific cation-containing polymer, but stickiness increases and the feel during use is not good.

On the other hand, water-soluble polymers used as stabilizers for external skin preparations include acrylic acid thickeners such as carbomer; It is well known that this can lead to poor stability.

Retinols are added to cosmetics such as serums, creams, and milky lotions for the purpose of preventing skin aging, such as preventing and improving wrinkles and sagging. However, it is well known that it has poor oxidative stability and is difficult to incorporate into formulations (Patent Document 5). On the other hand, in Patent Document 5, for the oxidative stability of retinols, a remarkable oxidative stability effect is obtained by combining green tea extract and rosemary extract as antioxidant ingredients, but Poor.

In other words, by blending retinol and its derivatives with nicotinic acid amide, it is possible to improve the firmness and elasticity of the skin, but it is also non-sticky, has an excellent feel, does not deposit crystals, and is resistant to odor caused by oxidation. A composition for external use on the skin is unknown.

Japanese Patent Application Publication No. 10-130135 Special Publication No. 2003-502435 Special Publication No. 2002-537241 Japanese Patent Application Publication No. 2018-172304 Japanese Patent Application Publication No. 2005-132745

The object of the present invention is to improve the feeling of use such as stickiness that occurs when a high amount of nicotinic acid amide is blended, and the precipitation that occurs during use and storage, and to prevent odor caused by oxidation of retinol and its derivatives.

In view of these circumstances, the present inventor has conducted extensive research to solve the above problems, and as a result, has found that a high skin care effect can be obtained by using a combination of nicotinamide, a water-soluble vitamin, and retinol, an oil-soluble vitamin. Furthermore, they discovered that the stickiness of nicotinic acid amide can be suppressed by blending a salt-resistant water-soluble polymer with a polyhydric alcohol. In addition, by increasing the amount of polyhydric alcohol, in which nicotinamide has originally low solubility, to at least twice the amount of nicotinamide and within the range of 25% by mass or less in the composition for external use on the skin, crystal precipitation can be prevented. It has been found that it is possible to simultaneously suppress this and provide a good usability.
The present invention was completed by discovering that by combining these, the firmness and elasticity of the skin is improved compared to when nicotinamide is used alone, and that the morphological changes of aging such as wrinkles and sagging can be prevented and improved. did.

That is, the present invention comprises the following components (A) to (D);
(A) Nicotinic acid amide 1-10% by mass
(B) Salt-resistant water-soluble polymer 0.05-1% by mass
(C) Retinol or its derivative 0.001 to 1% by mass
(D) Polyhydric alcohol 5-25% by mass
The present invention relates to an external skin preparation containing the following.

The blended mass ratio of component (D) and component (A) is
The present invention relates to a skin external composition in which (D)/(A)≧2.

The blended mass ratio of component (A) and component (C) is
This relates to a skin external composition in which (A)/(C)=1 to 1000.

This relates to a composition for external use on the skin, in which the salt-resistant water-soluble polymer of component (B) is one or more selected from polysaccharides or derivatives of polysaccharides, and copolymers containing acryloyl dimethyl taurine salt as a monomer. be.

The salt-resistant water-soluble polymer of component (B) is xanthan gum, hydroxypropyl methyl cellulose stearoxy ether, (Na acrylate/Na acryloyl dimethyl taurine) copolymer, (hydroxyethyl acrylate/Na acryloyl dimethyl taurine) copolymer, (acryloyl dimethyl taurine) The present invention relates to a composition for external use on the skin, which is one or more selected from ammonium/vinylpyrrolidone) copolymers.

The present invention relates to a sheet-like external preparation for skin, which is obtained by impregnating a sheet-like base material with the above-mentioned composition for external use.

The composition for external use on the skin of the present invention improves the firmness and elasticity of the skin, has no stickiness and has an excellent feel when used, and has excellent effects in suppressing crystal precipitation and odor caused by oxidation.

The present invention will be explained in detail below. Note that in this specification, "~" means a range that includes the numbers before and after it. In addition, numerical values expressed in % are based on mass, unless otherwise specified.

Component (A): Nicotinic acid amide Component (A) in the present invention, nicotinic acid amide (C6H6N2O/molecular weight: 122.12), is a water-soluble vitamin and is included in the vitamin B group. It is an amide compound of nicotinic acid (vitamin B3, niacin). In the present invention, a product extracted from rice bran or a product synthesized can be blended. Specifically, those listed in the Quasi-drug Ingredient Standards 2006 can be used. Solubility: It is known that it is easily soluble in water and ethanol, but difficult to dissolve in polyhydric alcohols and oils.

The blending amount of component (A) is 1 to 10% by mass (hereinafter simply abbreviated as "%"). More preferably, it is 3 to 8%. When the amount of component (A) is within this range, effects can be obtained in terms of improving rough skin and improving skin firmness and elasticity. Incidentally, even if the amount exceeds 10%, the effect tends to reach a plateau.

Component (B): Salt-resistant water-soluble polymer Component (B) salt-resistant water-soluble polymer in the present invention is a water-soluble polymer that exhibits sufficient viscosity even when electrolytes such as salts and metal oxides are dissolved in water. It is a polymer. As a specific structure, polysaccharides or their derivatives, copolymers containing acryloyl dimethyl taurine salts as monomers, etc. can be suitably used, and they can be contained alone or in an appropriate combination of two or more types. .

Examples of polysaccharides or derivatives thereof include gum arabic, gum tragacanth, galactan, guar gum, carob gum, gum karaya, carrageenan, pectin, agar, quince seed (quince), algae colloid (cassava extract), starch (rice, corn, potato, wheat). ), vegetable polymers such as glycyrrhizic acid; microbial polymers such as xanthan gum, dextran, succinoglycan, bullulan; starch polymers such as carboxymethyl starch, methylhydroxypropyl starch; methylcellulose, nitrocellulose, ethylcellulose, Cellulose polymers such as methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, hydroxypropyl methyl cellulose stearoxy ether, sodium carboxymethyl cellulose (CMC), crystalline cellulose, cellulose powder; sodium alginate, alginate propylene glycol ester, etc. Examples include alginic acid-based polymers.
Copolymers containing acryloyl dimethyl taurate salt as a monomer include (Na acrylate/Na acryloyl dimethyl taurate) copolymer, (Hydroxyethyl acrylate/Na acryloyl dimethyl taurate) copolymer, (ammonium acryloyl dimethyl taurate/vinyl pyrrolidone) Examples include copolymers and the like.

Suitable commercially available salt-resistant water-soluble polymers include xanthan gum such as Echo Gum and Keltrol (CP manufactured by Kelco), and hydroxypropyl methyl cellulose stearoxy ether such as Sungelose (manufactured by Daido Kasei) and ( As the Na acrylate/Na acryloyldimethyltaurine) copolymer, SIMULGEL EG (manufactured by Sepik), as the (hydroxyethyl acrylate/Na acryloyldimethyltaurine) copolymer, SEPINOV EMT10 (manufactured by Sepik), (ammonium acryloyldimethyltaurate/ Examples of vinylpyrrolidone copolymers include ARISTOFLEX AVC (manufactured by Clariant) and the like.

The blending amount of component (B) is 0.05 to 1%. More preferably, it is 0.1 to 0.5%. Within this range, the stickiness reducing effect and crystal precipitation suppressing effect are also excellent.

Component (C): Retinol or its derivative Retinol, component (C) in the present invention, is an oil-soluble vitamin consisting of a cyclohexene ring having a side chain containing conjugated polyunsaturation. It is well known that it is essential for humans and plays an important role in vision. Recently, it has been added to cosmetics for the purpose of preventing skin aging, such as preventing and improving wrinkles and sagging, but due to its structure, it does not have sufficient oxidative stability to be added to general skin external compositions. , which often causes foul odors.
The retinol derivative that is component (C) in the present invention is not particularly limited, and examples thereof include retinol acetate, retinol palmitate, tocopheryl retinoate, and the like.
Component (C) may be used alone or in combination.

Component (C) is usually commercially available as a solution diluted with an oily base material, and those commercially available for cosmetics or pharmaceuticals can be suitably used. Particularly suitable are corn oil, retinol diluted with caprylic/capric acid triglyceride, retinol palmitate, tocopheryl retinoate, and vitamin A oil because they are easy to incorporate into prescription systems.

The content of component (C) is preferably 0.001 to 1% in pure terms, more preferably 0.01 to 0.5%. By controlling the blending amount of component (C) to 1% or less, the irritation to the skin will be at a level that poses no problem. Furthermore, it becomes easier to suppress odor caused by oxidation and decomposition. When used in combination with component (A) as in the present invention, evaluations of firmness and elasticity are significantly improved.

Component (D): Polyhydric alcohol Component (D) polyhydric alcohol in the present invention is blended to suppress crystal precipitation of component (A). Polyhydric alcohol alone has little effect on suppressing crystal precipitation due to its low solubility, but good results can be obtained when used in combination with a salt-resistant water-soluble polymer.
Component (D) is not particularly limited as long as it is commonly used in external skin preparations, but for example, it may be an alkanediol such as 1,3 butylene glycol, which is a dihydric alcohol, or a trivalent or higher alcohol. Glycerin or diglycerin, saccharides or sugar alcohols with many hydroxyl groups may be used, and one or more types can be appropriately selected and used as required.

The amount of component (D) to be blended is at least twice that of component (A) in order to dissolve component (A) and suppress crystal precipitation. Furthermore, if the amount of component (D) is less than twice the amount of component (A), when the composition for external use on the skin is used, water evaporates and the composition for external use on the skin becomes concentrated, resulting in Nicotinic acid amide crystals may precipitate on the side of the container where the external skin composition has dripped. In addition, if a large amount of polyhydric alcohol is blended, it tends to feel sticky during use, so it is preferably 25% or less.

By incorporating the above-mentioned components (A) to (D), the skin external composition of the present invention improves the firmness and elasticity of the skin, prevents and improves the morphological changes of aging such as wrinkles and sagging, and also prevents irritation. It becomes possible to create a composition for external use on the skin that has an excellent feel when used without feeling or stickiness, and has an excellent effect of suppressing crystal precipitation and oxidation stability.

Furthermore, when the mass ratio (A)/(C) of component (A) and component (C) in the composition for external use on the skin is 1 to 1000, the effect of improving the firmness and elasticity of the skin by the composition for external use on the skin is It is preferable because it becomes noticeable synergistically.

As component (E), active ingredients such as various plant extracts can be used in combination. For example, rose cherry, lily, striped broom, gajutsu, tea, rhododendron, Japanese angelica, hibiscus, tormentilla, baobab, iris, sunflower, dayflower, daylily, safflower, Korean ginseng, pearl barley, horsetail, ginkgo, jojoba, terminaria, chickweed, corn, Whole plants, flowers, leaves, roots, fruits, etc. of Japanese crocodile, pomegranate, meshimakobu, rose hip, evening primrose, chamomile, soybean, white bean, mandarin orange, osmanthus, black carrot, white strawberry, Himalayan raspberry, elm tree, sweet marjoram, and modama. One or more types of extracts can be blended.

In addition to the above-mentioned components, the skin external composition of the present invention may include optional components that are included in ordinary skin external compositions within a range that does not impede the effects of the present invention, i.e., aqueous components and oil agents other than the above-mentioned essential components. , powder, film forming agent, surfactant, oil-soluble gelling agent, organically modified clay mineral, resin, coloring agent, ultraviolet absorber, preservative, antibacterial agent, fragrance, antioxidant, pH adjuster, chelating agent , beauty ingredients, etc. can be blended.

The skin external composition of the present invention can also be made into various dosage forms by using it in combination with other ingredients. Specifically, it can be carried out in various dosage forms such as liquid, gel, paste, cream, solid, and sheet.

The external skin composition of the present invention is suitable for preparing not only cosmetics but also quasi-drugs containing a high amount of nicotinamide, especially as anti-aging cosmetics. Examples of cosmetic applications include lotions, milky lotions, creams, beauty essences, massage cosmetics, pack cosmetics, hand creams, body lotions, and body creams. Examples of how to use it include using it on hands, fingers, cotton, impregnating it into a nonwoven fabric, and making it into an aerosol using a propellant.

The present invention will be described in more detail below with reference to Examples, but the present invention is not limited thereto. Unless otherwise specified, the blending amount is expressed in mass % based on the system in which the component is blended.

Experiment 1: Effect of nicotinamide on thickener Using 1% carbomer gel, changes in viscosity depending on the amount of nicotinamide blended were confirmed. The results are shown in Table 1.
(experimental method)
A 1:1% carbomer aqueous solution was adjusted to pH 6.5 using potassium hydroxide and gelled to form a 1% carbomer gel.
2: A predetermined amount of nicotinic acid amide was added to the above 1% carbomer gel, and after uniformly dissolving it, it was left to stand at 20° C. for 4 hours and the viscosity was measured. The degree of viscosity reduction was calculated based on the formula of Equation 1.
(Measurement condition)
Measuring equipment: VISCOTESTER TVB-10 manufactured by Toki Sangyo Co., Ltd.
Measurement conditions: Rotor M3, rotation speed 12 rpm, after 60 seconds at 20°C

(Consideration)
In a low concentration region where the amount of nicotinamide blended was less than 1%, the viscosity decrease was small. Although nicotinamide is an electrolyte, it has been suggested that it has relatively little effect on reducing the viscosity of water-soluble polymer gels that are sensitive to electrolytes, such as carbomer, which is commonly used as a thickening stabilizer in cosmetics. Ta. However, this experiment has shown that when the blending amount exceeds 1% and becomes a high concentration, a clear decrease in viscosity occurs. Therefore, there was concern that poor stability such as separation would be more likely to occur.
In addition, when a similar test was conducted using sodium chloride, the results were as follows.
When 0.1% of sodium chloride, a typical electrolyte, is added to 1% carbomer gel, the viscosity is 35.3 mPa. s (Measurement conditions: rotor M1, rotation speed 60 rpm, after 60 seconds at 20°C) Viscosity reduction degree = 99.4%

Invention products 1 to 10 and comparative products 1 to 11
The formulations shown in Table 2 below were prepared and evaluated for skin firmness/elasticity, stickiness, and crystal precipitation inhibiting effect using the following methods. The results are also shown in Table 2.

(Evaluation item)
Skin firmness and elasticity Non-stickiness Crystal precipitation suppression effect Oxidation stability

(Evaluation method)
[Sensory evaluation method for skin firmness, elasticity, and non-stickiness]
The evaluation was conducted by a professional panel of 10 women in their 20s to 40s who had received training in sensory evaluation. A panel of experts evaluated the stickiness of each sample immediately after application to the skin, and the firmness and elasticity of the skin the next morning.
A 5-level evaluation was performed using the following absolute evaluation, the average value was calculated, and the evaluation was made according to the following 4-level criteria.

(Method for evaluating skin firmness and elasticity)
(Score): (Evaluation)
5 points: I feel that my skin is very firm or elastic 4 points: I feel that my skin is firm or elastic 3 points: Average (I don't feel any change)
2 points: I don't really feel that my skin has firmness or elasticity. 1 point: I don't feel that my skin has firmness or elasticity. 4-level evaluation criteria (judgment): (Average score)
◎ : 4 points or more ○ : 3 points or more to less than 4 points △ : 2 points or more to less than 3 points × : Less than 2 points

(Evaluation method for non-stickiness)
(Score): (Evaluation)
5 points: Does not feel sticky 4 points: Almost does not feel sticky 3 points: Feels slightly sticky 2 points: Feels sticky 1 point: Feels very sticky 4-level evaluation criteria (judgment): (Average score)
◎ : 4 points or more ○ : 3 points or more to less than 4 points △ : 2 points or more to less than 3 points × : Less than 2 points

[Evaluation method of crystal precipitation suppression effect]
Regarding the evaluation of the effect of suppressing crystal precipitation, 4 g of the sample was applied to the bottom of a sterile petri dish (made of polystyrene: 90 mmΦ x 15 mm), and the dish was left standing in an open state (without a lid) in a 30° C. incubator for 24 hours. Thereafter, each sample was observed under a microscope. The state of crystal precipitation was observed using an optical microscope at a magnification of 40 times using a polarizing filter.
<Judgment criteria>
(Judgment): (Evaluation)
◎: No crystal precipitation.
○: Slight precipitation of crystals is observed.
×: Crystal precipitation is clearly observed.

[Evaluation method of stability over time]
For evaluation of stability over time, 100 g of each sample was filled into glass mayonnaise bottles and stored in a 50° C. incubator for 30 days, after which changes in properties were confirmed. Specifically, we checked to see if there was a strong rancid odor when used. Regarding the emulsions, changes in the emulsification state (presence or absence of separation) were also confirmed. If there was no change in the properties, write ``No change,'' if there was a strange odor, write ``Odd odor,'' and if separation was observed, write ``Separation.''

37.5% (Na acrylate/Na acryloyldimethyltaurine) copolymer/isohexadecane/polysorbate 80/water mixture *1 SIMULGEL EG: Hydroxypropyl methyl cellulose stearoxy ether manufactured by Sepik *2 Sungelose 60L: 65 manufactured by Daido Kasei % retinol palmitate diluted solution (diluted with corn oil) *3 Riken A Palmitate 1000E (V): Manufactured by Riken Vitamin Co., Ltd.

Manufacturing method: Water-based composition (lotion, essence)
Examples 1 to 3, Example 5, Examples 7 and 8, Comparative Examples 1 to 4, Comparative Example 6
A: Heat and dissolve 1, 2, and 10.
B: Add A to the purified water from Step 24 to solubilize.
C: Sequentially stir and dissolve other ingredients.
D: Once everything is dissolved, it is filtered to obtain the desired aqueous composition.
Production method: Oil-in-water emulsion composition (emulsion, cream)
Examples 4 and 6, Comparative Examples 5 and 7
A: Uniformly dissolve and mix 1 and 3 to 10 at 70°C.
B: Add the other ingredients one by one to the purified water in step 24, and uniformly dissolve and mix at 70°C.
C: Add A to B and emulsify at 70°C.
D: Stir and cool to 40°C to obtain the desired oil-in-water emulsion composition.

As is clear from the results in Table 2, the skin external compositions of Examples 1 to 8 of the products of the present invention are the same as those of Comparative Examples 1 to 7, whether they are water-based compositions or oil-in-water emulsion compositions. Compared to the external skin composition, better results were obtained in terms of skin firmness and elasticity, non-stickiness, crystallization suppressing effect, and stability over time.
On the other hand, Comparative Products 1 and 2, which contained only one of Components (A) and (C), were rated low in terms of skin firmness and elasticity. In Comparative Example 3 in which component (B), which is a salt-resistant water-soluble polymer, was not blended, crystal precipitation occurred. Crystal precipitation also occurred in Comparative Example 4 in which the amount of polyhydric alcohol blended was less than the claimed range. The oil-in-water emulsion composition of Comparative Example 5, in which carbomer, a common thickener, was used instead of a salt-resistant water-soluble polymer had no problems after production, but the stability over time was Upon confirmation, separation occurred. Furthermore, crystal precipitation also occurred. Comparative Example 6, in which ethanol, which is a monohydric alcohol, was blended instead of polyhydric alcohol had a good feel with less stickiness, but crystal precipitation occurred. The oil-in-water emulsion composition of Comparative Example 7, which contained a large amount of retinol palmitate, had no problems with the feeling of use, crystal precipitation, or separation stability in the stability test over time, but it developed a strong rancid odor and was difficult to use. It was unbearable.

Example 9: Oil-in-water moisturizing cream (ingredients) (mass%)
1.1,3-butylene glycol 12.0
2. Diglycerin 3.0
3. Purified water (appropriate amount) 4. Nicotinic acid amide 6.0
5. Methyl paraoxybenzoate 0.1
6. (Hydroxyethyl acrylate/Na acryloyldimethyltaurine) copolymer *4 0.1
7. Xanthan gum 0.05
8.30% dilauroylglutamate lysine Na aqueous solution 0.3
9. Glyceryl monostearate 1.5
10. Sorbitan sesquioleate 0.3
11. Hydrogenated lecithin 0.1
12. Di(phytosteryl/octyldodecyl) lauroylglutamate 3.0
13.5% retinol diluted solution (diluted with caprylic/capric acid triglyceride/sodium ascorbate/tocopherol mixture) *5 0.5
14. Jojoba oil 5.0
15. shea butter 2.0
16. Squalane 1.0
17. Ceramide 3 0.1
18. Tocopherol 0.05
19. Cetostearyl alcohol 2.0
20. Behenyl alcohol 1.0

(Hydroxyethyl acrylate/Na acryloyldimethyltaurine) copolymer *4 SEPINOV EMT10: Manufactured by Sepik 5% retinol diluted solution (tri(caprylic acid/capric acid) glyceryl/sodium ascorbate/tocopherol mixture) *5 RETISTAR: Manufactured by BASF

(Production method)
A: Components 1 to 8 are uniformly dissolved and mixed at 70°C.
B: Components 9 to 20 are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: An oil-in-water moisturizing cream was obtained by cooling to 40°C.

The oil-in-water emulsion of Example 9 was a skin external composition with excellent skin firmness/elasticity, stickiness, crystal precipitation inhibiting effect, and stability over time.

Example 10: Oil-in-water emulsion serum (ingredients) (mass%)
1.1,3-butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Xylitol 3.0
4. Purified water (appropriate amount) 5. Nicotinic acid amide 4.0
6. (Acrylates/alkyl acrylate (C10-30)) crosspolymer
0.1
7.92% (acryloyldimethyltaurate ammonium/VP) copolymer
(t-butanol/water mixture) *6 0.1
8. Coconut oil fatty acid polyoxyethylene sorbitan (20E.O.) 0.5
9. Macadamia nut oil fatty acid phytosteryl 2.0
10 Light liquid isoparaffin 3.0
11. Dimethylpolysiloxane (5CS) 3.0
12.10% tocopheryl retinoate diluted solution
(Diluted with caprylic/capric triglyceride) 0.2
13. Tocopherol 0.01
14. Stearyl glycyrrhetinate 0.05
15.10% sodium hydroxide aqueous solution 0.5
16. Phenoxyethanol 0.2
17. Ethanol 5.0
18.0.3% water-soluble collagen aqueous solution 0.1
19.0.4% water-soluble elastin aqueous solution 0.1
20.1% sodium hyaluronate aqueous solution 0.1

92% (ammonium acryloyldimethyltaurate/VP) copolymer (t-butanol/water mixture) *6 ARISTOFLEX AVC: Manufactured by Clariant

(Production method)
A: Components 1 to 7 are uniformly dissolved and mixed at 70°C.
B: Components 8 to 14 are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After starting cooling of C, components 15 to 20 were sequentially added at 45°C, and then cooled to 40°C to obtain an oil-in-water emulsion serum.

The oil-in-water emulsion serum of Example 10 was a skin external composition with excellent skin firmness/elasticity, stickiness, crystal precipitation inhibiting effect, and stability over time.

Example 11: Water-based moisturizing gel (ingredients) (mass%)
1.1,2 pentanediol 0.5
2.1,3 butylene glycol 12.0
3. Methylglucose 10 3.0
4.37.5% (Na acrylate/Na acryloyldimethyltaurine) copolymer/isohexadecane/polysorbate 80/water mixture 0.3
5.5% polyquaternium-51 aqueous solution 0.3
6. Sodium hyaluronate 0.01
7. (PEG-240/decyltetradeceth-20/HDI) copolymer *7
1.0
8. Nicotinic acid amide 3.0
9. Dipotassium glycyrrhizinate 0.1
10.1% carbomer aqueous solution 10.0
11.10% potassium hydroxide aqueous solution 1.0
12.65% retinol palmitate diluted solution (diluted with corn oil) 0.1
13. PEG-100 hydrogenated castor oil 0.5
14. Ethylhexylglycerin 0.3
15. Purified water (appropriate amount)

(PEG-240/decyltetradeceth-20/HDI) copolymer *7 ADEKA NOL GT-700: Manufactured by ADEKA

(Production method)
A: Heat and dissolve components 12 to 14 in advance.
B: A and each component were added to component 15 and mixed, and the mixture was stirred until it became transparent and uniform to obtain a water-based moisturizing gel.

The aqueous moisturizing gel of Example 11 was an external skin composition with excellent skin firmness/elasticity, stickiness, crystal precipitation inhibiting effect, and stability over time.

Example 12: Sheet mask (non-woven fabric impregnated serum)
(Component) (mass%)
1.1,2 hexanediol 0.5
2.1,3 butylene glycol 10.0
3. Methylglucose 10 1.0
4. Xanthan gum 0.1
5. PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin 0.3
6. Sodium hyaluronate 0.01
7. Nicotinic acid amide 7.0
8. Dipotassium glycyrrhizinate 0.1
9. Glycerin 5.0
10. δ-tocopherol 0.05
11.65% retinol palmitate diluted solution (diluted with corn oil) 0.1
12. PPG-6 decyltetradeceth-30 0.5
13. Ethylhexylglycerin 0.2
14. Methylparaben 0.1
15. Purified water (appropriate amount)

(Production method)
A: Heat and dissolve components 10 to 14 in advance.
B: A and each component were added to component 15 and mixed, and the mixture was stirred until it became transparent and uniform to obtain a beauty serum.
C: A sheet mask was prepared by impregnating 30 g of this serum into a face-shaped nonwoven fabric (500 cm 2 , basis weight 60 g/m 2 , rayon/polypropylene = 70%/30%) and filling it into an aluminum sheet bag.

The sheet mask of Example 12 had excellent skin firmness and elasticity, no stickiness, no crystal precipitation during use, and excellent stability over time.

Example 13: Oil-in-water emulsion serum (serum containing various extracts)
(Component) (mass%)
1.1,3-butylene glycol 9.0
2. diglycerin 5.0
3. Maltose 3.0
4. Purified water (appropriate amount) 5. Nicotinic acid amide 4.0
6. Xanthan gum 0.1%
7. (Hydroxypropyl methyl cellulose stearoxy ether *2 0.1
8. PEG-50 hydrogenated castor oil 2.0
9. Di(phytosteryl lauroylglutamate/octyldodecyl) 2.0
10. Diphenylsiloxyphenyl trimethicone 3.0
11. Hydrogenated polyisobutene 3.0
12.10% tocopheryl retinoate diluted solution
(Diluted with caprylic/capric triglyceride) 0.2
13. Sorbitan sesquioleate 0.8
14. Stearyl glycyrrhetinate 0.05
15. Tocopherol 0.1
16. Phenoxyethanol 0.2
17. Rose extract 0.01
18. Cherry blossom extract 0.01
19. Lily extract 0.01
20. Shimaozuki extract 0.01
21. Gajutsu extract 0.01
22. Tea extract 0.01
23. Rhizoma extract 0.01
24. Angelica extract 0.01
25. Hibiscus extract 0.01
26. Tormentilla extract 0.01
27. Baobab extract 0.01
28. Eleisen extract 0.01
29. Sunflower extract 0.01
30. Cucumber extract 0.01
31. Licorice extract 0.01
32. Safflower extract 0.01
33. Korean ginseng extract 0.01
34. Coix barley extract 0.01
35. Horsetail extract 0.01
36. Ginkgo biloba extract 0.01
37. Jojoba extract 0.01
38. Terminaria extract 0.01
39. Chickweed extract 0.01
40. Corn extract 0.01
41. Hanaiguchi extract 0.01
42. Pomegranate extract 0.01
43. Meshimakobu extract 0.01
44. Rosehip extract 0.01
45. Evening primrose extract 0.01
46. Chamomile extract 0.01
47. Soybean extract 0.01
48. White bean extract 0.01
49. Mandarin orange extract 0.01
50. Osmanthus extract 0.01
51. Black carrot extract 0.01
52. White strawberry extract 0.01
53. Himalayan raspberry extract 0.01
54. Nemunoki extract 0.01
55. Sweet marjoram extract 0.01
56. Modama extract 0.01

Hydroxypropyl methyl cellulose stearoxy ether *2 Sangelose 60L: Manufactured by Daido Kasei Co., Ltd.

(Production method)
A: Components 1 to 7 are uniformly dissolved and mixed at 70°C.
B: Components 8 to 15 are uniformly dissolved and mixed at 80°C.
C: Add B to A and emulsify at 70°C.
D: After starting cooling of C, components 16 to 56 were sequentially added at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsion serum.

The oil-in-water emulsion serum of Example 13 was a skin external composition with excellent skin firmness/elasticity, stickiness, crystal precipitation inhibiting effect, and stability over time.

The present invention can be applied to cosmetics, quasi-drugs, external skin preparations, and the like.

Claims (3)

The following ingredients (A) to (D);
(A) Nicotinic acid amide 1-10% by mass
(B) 0.05 to 1% by mass of one or more selected from hydroxypropyl methyl cellulose stearoxy ether, (Na acrylate/Na acryloyl dimethyl taurate) copolymer, (ammonium acryloyl dimethyl taurate/vinyl pyrrolidone) copolymer
(C) Retinol or its derivative 0.001 to 1% by mass
(D) Polyhydric alcohol 5-25% by mass
including;
The blended mass ratio of component (D) and component (A) is
(D)/(A)≧2,
A composition for external use on the skin, characterized in that it is an aqueous composition .
The blended mass ratio of component (A) and component (C) is
The skin external composition according to claim 1, wherein (A)/(C) = 1 to 1000. A sheet-like composition for external use on skin, which is obtained by impregnating a sheet-like base material with the composition for external use on skin according to claim 1 or 2 .