JP2023097474A - Oil-in-water emulsion composition - Google Patents

Abstract

To improve use feelings such as stickiness observed when blending a high proportion of nicotinamide, and also improve precipitation observed during its use or storage, and further improve emulsion stability at sufficiently high temperatures.SOLUTION: An oil-in-water emulsion composition contains following components (A)-(E): (A) nicotinamide of 1-10 mass%, (B) an anionic surfactant, (C) a higher alcohol being solid at 20°C (D), gellan gum and (E) a polyhydric alcohol of 5-25 mass%.SELECTED DRAWING: None

Description

The present invention relates to an oil-in-water emulsified composition which has an excellent non-sticky feeling in use, an excellent effect of suppressing crystal precipitation, good emulsification stability at high temperatures, and an excellent whitening effect.

In recent years, as a product concept for cosmetics, many products aimed at improving age spots, wrinkles, sagging, pigmentation, etc. due to aging, stress, ultraviolet rays, air dryness, etc. have been released. In particular, many people want to improve skin color changes such as spots and pigmentation because they give the impression that aging has progressed. Nicotinamide as an active ingredient is known to have a whitening effect of preventing pigmentation by inhibiting transfer of melanin from pigment cells to epidermal cells (Non-Patent Document 1).

However, it is known that when a large amount of nicotinic acid amide is blended, stickiness, creaking, etc. occur, and a good feel during use cannot be obtained (Patent Document 1). In particular, in the case of an external skin composition containing 1% by mass or more of nicotinic acid amide, crystals of nicotinic acid amide precipitate when the content dries after adhering to the mouth or cap, or when adhering to the side of the container. It is known to do (Patent Document 2, Patent Document 3).

On the other hand, in Patent Document 1, by using a specific branched-chain hydrocarbon and a specific highly spreadable oil in combination, the stickiness when a large amount of nicotinic acid amide is blended can be suppressed, but the content is mouth-watering. In some cases, crystals adhered to the parts and caps and precipitated, hindering smooth opening and closing of the container. In addition, in the oil-in-water emulsion composition, by using an ester of a linear fatty acid and polyethylene glycol as an emulsifier and adding vaseline, 1% or more of nicotinic acid amide can be added. It has been reported to obtain an oil-in-water emulsified composition that is free from irritation and stickiness, has an excellent feeling in use, and has an excellent effect of inhibiting crystallization (Patent Document 4). However, in Patent Document 4, although a comprehensively good composition for external use on the skin is obtained, it is limited to an oil-in-water emulsion essentially containing petrolatum, and it is difficult to say that it has sufficient versatility. In Patent Document 2, crystal precipitation is improved by blending a specific cation-containing polymer, but the stickiness increases and the feeling of use is not good.

On the other hand, as a water-soluble polymer that is blended as a thickener for external skin preparations, acrylic acid-based thickeners such as carbomer can be mentioned, but they generally have poor salt tolerance, and depending on the type of electrolyte, they can significantly reduce viscosity or aggregate. It is well known that it causes poor stability due to the occurrence of For example, Patent Document 5 discloses a technique of using specific surfactants (polyoxyethylene-added castor oil and polyoxyethylene-added sorbitol fatty acid ester) to obtain stability at high temperatures. . Furthermore, since the room temperature in the summertime is rising due to climate warming, there is a need for formulations with higher resistance to high temperatures than ever before. Specifically, until now, it was thought that stability at 50°C or higher was sufficient, but in recent years, confirmation of storage stability up to about 60°C may be necessary. In general, increasing the storage temperature causes the viscosity to decrease and the stability to decrease significantly. In other words, storage at a higher temperature imposes a higher load on storage stability than storage at a lower temperature.

From the above, by blending nicotinic acid amide, it is possible to exhibit an excellent whitening effect, but it is not sticky and has an excellent feel when used, does not precipitate crystals, and has good emulsification stability even at high temperatures. Oil-type emulsified compositions are not yet known.

Japanese Patent Publication No. 2003-502435 Japanese Patent Publication No. 2002-537241 JP 2018-168105 A JP 2018-172304 A JP 2018-168146 A T. Hakozaki et al., British J.; Dermatology, 147, 20, 2002

An object of the present invention is to improve the feel of use such as stickiness that occurs when a large amount of nicotinic acid amide is blended, to improve precipitation that occurs during use and storage, and to have sufficient emulsion stability at high temperatures and excellent whitening effects. do.

In view of this situation, the inventors of the present invention, as a result of extensive research to solve the above problems,
the following components (A) to (E);
(A) Nicotinamide: 1 to 10% by mass
(B) Anionic surfactant (C) Higher alcohol solid at 20°C (D) Gellan gum (E) Polyhydric alcohol: 5 to 25 mass%
The inventors have found that an oil-in-water emulsion composition containing can solve the above problems, and have completed the present invention.

The present invention further relates to an oil-in-water emulsion composition in which the blending mass ratio of component (E) and component (A) is (E)/(A)≧2.

The present invention can further contain (F) a water-soluble whitening agent.

The present invention is (F) an oil-in-water emulsion composition in which the water-soluble whitening agent is one or more water-soluble whitening agents selected from ascorbic acid derivatives and salts thereof, tranexamic acid, and arbutin.

The oil-in-water emulsified composition of the present invention is non-sticky and has an excellent feel in use, and has excellent effects of suppressing crystal precipitation, high-temperature emulsion stability, and whitening effect.

The present invention will be described in detail below. In this specification, "-" shall mean a range including numerical values before and after it. In addition, numerical values expressed in % are values based on mass unless otherwise specified.

Component (A) nicotinic acid amide (C6H6NO/molecular weight: 122.12) in the present invention is a water-soluble amide compound of nicotinic acid (vitamin B3, niacin). In the present invention, one extracted from rice bran or one synthesized can be blended. Specifically, those listed in the Japanese Pharmacopoeia 2008, 15th Edition can be used. It is readily soluble in water and ethanol, and sparingly soluble in diethyl ether. It is known to be difficult to dissolve in polyhydric alcohols and oils.

The blending amount of component (A) is 1 to 10% by mass (hereinafter simply abbreviated as “%”). More preferably 2 to 8%. When the amount of the component (A) is within this range, an effect of improving stains and pigmentation can be obtained. Even if the content exceeds 10%, the effect tends to reach a peak, and in addition, crystals may precipitate when the water in the composition evaporates.

Examples of (B) anionic surfactants in the present invention include fatty acid salts derived from fatty acids having 12 to 24 carbon atoms, such as sodium laurate, potassium palmitate, and arginine stearate; sodium lauryl sulfate, potassium lauryl sulfate; Alkyl sulfate ester salts such as polyoxyethylene lauryl sulfate triethanolamine; Alkyl ether sulfate ester salts such as triethanolamine lauroyl sarcosinate; N-acylsarcosine salts such as sodium lauroyl sarcosinate; fatty acid amide sulfonates such as sodium methyltaurate; alkyl phosphates such as potassium monocetyl phosphate; polyoxyethylene alkyl ether phosphates such as sodium polyoxyethylene oleyl ether phosphate and sodium polyoxyethylene stearyl ether phosphate; -long-chain sulfosuccinates such as sodium 2-ethylhexyl sulfosuccinate; monosodium N-lauroyl glutamate, sodium N-stearoyl-L-glutamate, arginine N-stearoyl-L-glutamate, sodium N-stearoyl glutamate, N-myristoyl- long-chain N-acylglutamates such as sodium L-glutamate; Among these, alkyl phosphate and long-chain N-acyl glutamate are preferred, and cetyl phosphate and stearoyl glutamate are more preferred.

The amount of component (B) to be blended is not particularly limited, but is desirably 0.1 to 3%, more preferably 0.3 to 1%.

The number of carbon atoms in the (C) higher alcohol that is solid at 20° C. in the present invention is not particularly limited, but linear saturated alcohols having 16 or more carbon atoms are preferred. Examples include cetyl alcohol, stearyl alcohol, behenyl alcohol and the like.

The amount of component (C) is not particularly limited, but is preferably 0.2 to 5%, more preferably 0.5 to 3%.

(D) gellan gum in the present invention is a heteropolysaccharide obtained by pure culture of the bacterium Pseudomonaselodea using glucose as a substrate. Gellan gum can also be used without particular limitations. Among these, it is preferable to use native gellan gum.

The amount of component (D) is not particularly limited, but is preferably 0.01 to 1%, more preferably 0.02 to 0.5%. If the blending amount exceeds 1%, stickiness may occur. Commercially available Kelcogel and Kelcogel HM (both from CP Kelco) can also be used.

Component (E) polyhydric alcohol in the present invention is blended to dissolve component (A) and suppress crystal precipitation. A polyhydric alcohol alone has almost no effect of suppressing crystal precipitation, but good results can be obtained by using it together with (D) gellan gum. Component (E) is not particularly limited as long as it is commonly used in external compositions. Glycerin, diglycerin, saccharides and sugar alcohols with many hydroxyl groups may be used, and if necessary, one or more of them can be appropriately selected and used.

The blending amount of component (E) is desirably 25% or less, because if a large amount of polyhydric alcohol is blended, stickiness tends to occur in terms of feel during use. On the other hand, in order to dissolve component (A) and suppress crystal precipitation, component (E) must be contained in an amount of 5% or more of the entire composition, and more than twice the amount of component (A). Crystal precipitation can be suppressed more preferably.

The oil-in-water emulsion composition of the present invention improves skin color changes such as spots and pigmentation by blending the above components (A) to (E), and provides a feeling of use without irritation or stickiness. It is possible to obtain an oil-in-water emulsified composition that is excellent, has an excellent effect of suppressing crystal precipitation, and has excellent high-temperature emulsification stability.

The present invention can further contain (F) a water-soluble whitening agent. The water-soluble whitening agent is not particularly limited, but the whitening effect can be enhanced by adding one or more water-soluble whitening agents selected from ascorbic acid derivatives and salts thereof, tranexamic acid, and arbutin.

In addition to the above components, the oil-in-water emulsion composition of the present invention includes optional components that are blended in ordinary oil-in-water emulsion compositions within a range that does not hinder the effects of the present invention, that is, other than the above essential components, Aqueous component, oil, powder, film-forming agent, surfactant, oil-soluble gelling agent, organically modified clay mineral, resin, colorant, ultraviolet absorber, preservative, antibacterial agent, fragrance, antioxidant, pH adjustment agents, chelating agents, cosmetic ingredients and the like can be blended.

The oil-in-water emulsion composition of the present invention can be used in combination with other ingredients to form various dosage forms. Specifically, various dosage forms such as liquid, gel, paste, cream, solid, and sheet can be used.

INDUSTRIAL APPLICABILITY The oil-in-water emulsified composition of the present invention is suitable for preparing quasi-drugs containing a large amount of nicotinic acid amide in anticipation of an anti-aging effect, in addition to cosmetics. Specifically, for example, it can be used in lotions, milky lotions, creams, beauty essences, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, and the like. The method of use includes methods such as using with hands, fingers, cotton, impregnating non-woven fabrics, and aerosolizing with a propellant.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these. Unless otherwise specified, the blending amount is shown in % by mass relative to the system in which the component is blended.

Experiment 1: Effect of nicotinamide on thickening agent Using 1% carbomer gel, the change in viscosity depending on the amount of nicotinamide blended was confirmed. Table 1 shows the results.
(experimental method)
(1): A 1% carbomer aqueous solution was adjusted to pH 6.5 using potassium hydroxide and gelled to form a 1% carbomer gel.
(2): A predetermined amount of nicotinic acid amide was added to the above 1% carbomer gel, dissolved uniformly, allowed to stand at 20°C for 4 hours, and the viscosity was measured. The degree of decrease in viscosity was calculated based on the formula (1).
(Measurement condition)
Measuring instrument: VISCOTESTER TVB-10 manufactured by Toki Sangyo Co., Ltd.
Measurement conditions: Rotor M3, rotation speed 12 rpm, after 60 seconds, under 20°C environment

(Discussion)
In the low-concentration range where the amount of nicotinic acid amide blended did not reach 1%, the decrease in viscosity was small. Although nicotinamide is an electrolyte, it is suggested that it has relatively little effect on the viscosity reduction of water-soluble polymer gels that are sensitive to electrolytes, such as carbomer, which is widely used as a thickening stabilizer for cosmetics. rice field. However, this experiment shows that when the blending amount exceeds 1% and the concentration becomes high, a clear decrease in viscosity occurs. Therefore, there was a concern that poor stability such as separation is likely to occur.
Incidentally, when the same test was conducted using sodium chloride, the results were as follows.
When 0.1% sodium chloride, which is a typical electrolyte, is added to 1% carbomer gel, the viscosity is 35.3 mPa.s. s (measurement conditions: rotor M1, rotation speed 60 rpm, after 60 seconds, under 20°C environment) Viscosity reduction = 99.4%

Products 1 to 12 of the present invention and comparative products 1 to 8: Oil-in-water emulsion An oil-in-water emulsion cream having the formulation shown in Table 2 below was prepared, and the absence of stickiness, the effect of suppressing crystal precipitation, and the emulsification stability at high temperature were evaluated as follows. was evaluated by the method of Moreover, Example 1, Example 2, and Comparative Example 8 evaluated the whitening effect. The results are also shown in Table 2.

(Evaluation item)
Non-sticky Crystal precipitation suppression effect Emulsification stability at high temperature Whitening effect

(Evaluation method)
[Method for sensory evaluation of lack of stickiness]
Evaluation was performed by 10 professional panelists who were women in their 20s to 40s who had undergone sensory evaluation training. Each sample was evaluated for stickiness immediately after application to the skin by expert panelists.
Five-level evaluation was performed in the following absolute evaluation, the average value was calculated, and evaluation was made according to the following four-level evaluation criteria.

[Evaluation method for non-stickiness]
(score): (evaluation)
5 points: Does not feel sticky
4 points: hardly feels sticky
3 points: Slightly sticky
2 points: feels sticky
1 point: Feels very sticky 4-step judgment criteria (Judgment): (Average score)
◎ : 4 points or more
○: 3 points or more to less than 4 points
△: 2 points or more to less than 3 points
×: Less than 2 points

[Evaluation method of crystal precipitation suppression effect]
For the evaluation of the effect of suppressing crystal precipitation, 4 g of the sample was applied to the bottom of a sterilized petri dish (made of polystyrene: 90 mmΦ×15 mm) and allowed to stand in an open state (with no lid) in a 30° C. incubator for 24 hours. Each sample was then observed under a microscope. The state of crystal precipitation was observed with a 40x optical microscope using a polarizing filter.
<Judgment Criteria>
(judgment): (evaluation)
A: No precipitation of crystals.
◯: Slight precipitation of crystals is observed.
x: Precipitation of crystals is clearly observed.

[Evaluation method for emulsion stability at high temperature]
(Evaluation of emulsion stability)
The samples of Examples 1 to 12 and Comparative Examples 1 to 8 were stored under a temperature condition of 60° C. for 2 weeks, visually observed for changes in appearance, and judged according to the following 3-step judgment criteria.
Three-stage judgment criteria (judgment): (evaluation result)
◎: no change, uniform: very good ○: no change in 1 week, separation observed after 2 weeks: good ×: separation observed within 1 week: poor

[Evaluation method for whitening effect]
Twenty women in their 30s to 50s were divided into two groups. The first group was a sample containing nicotinic acid amide and a water-soluble whitening agent on the half face (Example 1), and the other was a placebo (Comparative Example 8). was applied twice a day, the second group was a sample in which nicotinic acid amide was blended on the half face (Example 2), and the other group was asked to apply a placebo twice a day for 8 weeks. The front and half faces of the face before and after continuous use were photographed using a facial photography mini studio VISIA-CR (manufactured by CANFIELD). Photographs were taken with the color chart for image correction attached to the subject's forehead, and the white balance of the color chart was adjusted using Photoshop (Adobe Systems Incorporated) (registered trademark) functions. Images for analysis were obtained by correcting each photographed image. Based on comparison of images for analysis before and after continuous use, the "whitening effect" was evaluated by a panel of three cosmetics evaluation specialists. Evaluation criteria are as follows. The samples were rated according to the following 5-grade evaluation criteria, and the average score of all the panels was determined according to the following 4-grade evaluation criteria.
(Rating)
5 points: particularly excellent whitening effect 4 points: excellent whitening effect 3 points: whitening effect 2 points: slight whitening effect 1 point: no whitening effect Results are shown based on the following criteria from the average values. rice field.
(Evaluation criteria)
◎: Average score of 4 or more ○: Average score of 3 or more and less than 4 △: Average score of 2 or more and less than 3 ×: Average score of less than 2

Sodium Stearoyl Glutamate *1 Amisoft HS-11P Ajinomoto Healthy Supply Potassium Cetyl Phosphate *2 AMPHISOL K DSM Nutrition Gellan Gum *3 Kelco Gel HM CP Kelco (Note that *1, *2 and *3 described below are each point to the same thing)

Production method (a): 1 to 12 are uniformly dissolved and mixed at 70°C.
(b): Other ingredients are added to the purified water of 25 in sequence, and dissolved and mixed uniformly at 70°C.
(c): (a) is added to (b) and emulsified at 70°C.
(d): Stir and cool to 40° C. to obtain the desired composition.

As is clear from the results in Table 2, the oil-in-water emulsion compositions of Examples 1 to 12 of the products of the present invention are less sticky, less effective in suppressing crystal precipitation, and more stable at high temperatures than in Comparative Examples 1 to 8. Good results were obtained in all aspects. In addition, the whitening effects of Examples 1 and 2 were observed, and particularly excellent effects were confirmed in Example 1, in which a water-soluble whitening agent was added in addition to nicotinic acid amide.
On the other hand, the comparative products 1 and 2 containing no (B) anionic surfactant showed significant separation within 3 days in the stability test over time, and gave a sticky feeling during use. (C) Comparative Example 3, which does not contain a higher alcohol that is solid at 20° C., and Comparative Example 4, which uses isostearyl alcohol, which is a branched-chain saturated alcohol that is liquid at 20° C., were tested for stability over time. Noticeable separation was seen by the next day. (D) In Comparative Example 5 containing no gellan gum, precipitation of crystals was confirmed, and significant separation was observed within 3 days. (D) In Comparative Example 6, in which xanthan gum, which is a general-purpose thickening agent, was used instead of gellan gum, crystal precipitation and significant separation were observed within one week. (E) Crystal precipitation occurred in Comparative Example 7 in which the monohydric alcohol ethanol was blended instead of the polyhydric alcohol. In addition, almost no whitening effect was observed in Comparative Example 8, which does not contain nicotinic acid amide.

Example 13: Oil-in-water sunscreen cream (ingredient) (mass%)
1.1,3-butylene glycol 12.0
2. Diglycerin 3.0
3. Purified water Appropriate amount 4. Nicotinamide 6.0
5. Methyl paraoxybenzoate 0.1
6. Sucrose stearate 1.0
7. (Hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer *4 0.1
8. Gellan gum *3 0.05
9.30% dilauroyl glutamate lysine Na aqueous solution 0.3
10. Glyceryl monostearate 1.5
11. Sorbitan sesquioleate 0.3
12. Hydrogenated lecithin 0.1
13. Di(phytosteryl/octyldodecyl) lauroyl glutamate 3.0
14. Diethanolamine cetyl phosphate *5 0.5
15. Ethylhexyl methoxycinnamate 5.0
16. Diethylaminohydroxybenzoyl hexyl benzoate 1.0
17. Jojoba oil 5.0
18. Shea butter 2.0
19. Squalane 1.0
20. Ceramide 3 0.1
21. Tocopherol 0.05
22. Cetostearyl alcohol 2.0
23. Cholesterol 0.3
24. Ubiquinone 0.001
25. Hydrogenated polyisobutene 2.0
26.40% polyacrylamide solution 0.3

(Hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer *4 SEPINOV EMT10: diethanolamine cetyl phosphate manufactured by Seppic *5 AMPHISOL: manufactured by DSM Nutrition

(Production method)
(a): Components 1 to 9 are uniformly dissolved and mixed at 70°C.
(b): Components 10 to 25 are uniformly dissolved and mixed at 80°C.
(c): Add (b) to (a) and emulsify at 70°C.
(d): Add 26 to (c) and mix until uniform.
(e): Cooled to 40°C to obtain an oil-in-water sunscreen cream.

The oil-in-water sunscreen cream of Example 13 was an external composition for skin with excellent whitening effect, stickiness, crystal precipitation suppressing effect, and long-term stability.

Example 14: Oil-in-water emulsified beauty essence (ingredient) (mass%)
1.1,3-butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Xylitol 3.0
4. Purified water Appropriate amount5. Nicotinamide 4.0
6. Gellan gum *3 0.1
7.92% (acryloyldimethyltaurate ammonium/VP) copolymer/(t-butanol/water mixture) *6 0.1
8. Coconut fatty acid polyoxyethylene sorbitan (20 E.O.) 0.5
9. Macadamia nut oil fatty acid phytosteryl 2.0
10. Cetanol 3.0
11. Dimethylpolysiloxane (5CS) 3.0
12. Sodium stearoyl glutamate *2 0.2
13. Polyglyceryl-5 myristate 1.0
14. Tocopherol 0.1
15. Stearyl glycyrrhetinate 0.05
16.10% sodium hydroxide aqueous solution 0.5
17. Phenoxyethanol 0.2
18. Ethanol 5.0
19.0.3% water-soluble collagen aqueous solution 0.1
20.1% sodium hyaluronate aqueous solution 0.1
21. Tremella fungus polysaccharide 0.1
22.10% sodium ascorbyl phosphate aqueous solution 10.0

92% (acryloyldimethyltaurate ammonium/VP) copolymer (t-butanol/water mixture) *6 ARISTOFLEX AVC: manufactured by Clariant

(Production method)
(a): Components 1 to 8 are uniformly dissolved and mixed at 70°C.
(b): Components 9 to 15 are uniformly dissolved and mixed at 80°C.
(c): Add (b) to (a) and emulsify at 70°C.
(d): After starting cooling of (c), components 18 to 22 were sequentially added at 45°C, and then cooled to 40°C to obtain an oil-in-water emulsified beauty essence.

The oil-in-water emulsified beauty essence of Example 14 was an external composition for skin with excellent whitening effect, stickiness, crystal precipitation suppressing effect, and long-term stability.

Example 15: Water-based moisturizing gel (component) (% by mass)
1.1,2-pentanediol 0.5
2.1,3-butylene glycol 12.0
3. Methyl gluceth-10 3.0
4.37.5% (Na acrylate/Na acryloyldimethyltaurate) copolymer/isohexadecane/polysorbate 80/water mixture *7 0.3
5.5% polyquaternium-51 aqueous solution 0.3
6. Gellan gum *3 0.05
7. (PEG-240/decyltetradeceth-20/HDI) copolymer *8
0.7
8. Nicotinamide 3.0
9. Tranexamic acid 2.0
10. Carbomer 0.1
11.10% potassium hydroxide aqueous solution 1.0
12. Potassium cetyl phosphate *2 0.2
13. Cetanol 0.4
14. PEG-100 hydrogenated castor oil 0.5
15. Ethylhexylglycerin 0.3
16. Purified water Appropriate amount

37.5% (Na acrylate/Na acryloyldimethyltaurate) copolymer/isohexadecane/polysorbate 80/water mixture *7 SIMULGEL EG QD: (PEG-240/decyltetradeceth-20/HDI) copolymer manufactured by Sepik * 8 Adekanol GT-700: manufactured by Adeka

(Production method)
(a): Ingredients 12 to 14 are heated and dissolved in advance.
(b): To component 15, components (a) and each of components 1 to 11 were added and mixed, and the mixture was stirred until transparent and uniform to obtain a water-based moisturizing gel.

The water-based moisturizing gel of Example 15 was an external composition for skin with excellent whitening effect, stickiness, crystal precipitation suppressing effect, and long-term stability.

Example 16: Sheet mask (Nonwoven fabric impregnated serum)
(Component) (% by mass)
1.1,2-hexanediol 0.5
2.1,3-butylene glycol 10.0
3. Methyl gluceth-10 1.0
4. (Acrylates/C10-30 alkyl acrylate) crosspolymer
0.05
5. Gellan gum *3 0.1
6. Xanthan gum 0.2
7. PEG/PPG/polybutylene glycol-8/5/3 glycerin 0.3
8. Sodium hyaluronate 0.01
9. Nicotinamide 7.0
10. Starch Octenyl Succinate Al 0.5
11. Dipotassium glycyrrhizinate 0.1
12. Glycerin 5.0
13. Cetanol 0.1
14. Cetyl phosphate *9 0.1
15. PPG-6 decyltetradeceth-30 0.5
16. Ethylhexylglycerin 0.2
17. Methylparaben 0.1
18. Purified water Appropriate amount 19.10% potassium hydroxide aqueous solution 0.2
Cetyl phosphate Hostaphat CC100 *9 manufactured by Clariant

(Production method)
(a): Ingredients 12 to 17 are heated and dissolved in advance.
(b): Component (a) and each of components 1 to 11 were added to component 18, mixed and stirred until uniform to obtain a beauty essence.
(c): 19 was added to (b) and mixed to prepare a stock solution for a sheet mask.
(d): Impregnate 30 g of this serum into a face-shaped non-woven fabric (500 cm2, basis weight 60 g/m2, rayon/polypropylene = 70%/30%), fill it in an aluminum sheet bag, and prepare a sheet mask. bottom.

The sheet mask of Example 16 had a whitening effect, no stickiness, no crystal deposition during use, and excellent stability over time.

Example 17: All-in-one gel (component) (mass%)
1. Diisostearyl malate 1.0
2. behenyl alcohol 1.0
3. Cetyl ethylhexanoate 4.0
4. Dimethicone 1.5
5. Squalane 4.0
6. Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) 1.0
7. Cocoyl methyl taurate sodium 1.0
8. Sorbitan sesquioleate 0.8
9. Sucrose stearate 2.0
10. Polyglyceryl-10 stearate 1.5
11. PEG-50 hydrogenated castor oil 1.0
12. Tocopherol 0.1
13. water appropriate amount 14.1,3-butylene glycol 10.0
15. Hydroxypropyl methylcellulose stearoxy ether *10 0.1
16. Glycerin 15.0
17. Carbomer 0.1
18. Gellan gum *3 0.1
19. Propynyl iodide butylcarbamate 0.003
20. Ethylhexylglycerin 0.2
21. Nicotinamide 4.0
22. Phenoxyethanol 0.2
23. Arbutin 3.0
24. Retinol palmitate/corn oil mixture 0.001
25.10% arginine aqueous solution 1.0
26. Sodium glutamate 0.01
27. Creatinine 0.01
28. Centella asiatica extract 0.01
29. Hibiscus flower extract 0.01
30. Hydrolyzed hyaluronic acid 0.01
31. Comfrey leaf extract 0.01
32. Hydrolyzed elastin 0.01
33. Hydrolyzed soy protein 0.01
34. Mandarin orange peel extract 0.01
35. Lactobacillus / pear juice fermentation liquid 0.01
36. Pearl barley seed extract 0.01
37. Alpinia purpurea leaf extract 0.01

Hydroxypropyl methylcellulose stearoxy ether *10 Sangelose 60L: manufactured by Daido Kasei Co., Ltd.

(Production method)
(a): Components 1 to 12 are uniformly dissolved and mixed at 70°C.
(b): Components 13 to 24 are uniformly dissolved and mixed at 80°C.
(c): (a) is added to (b) and emulsified at 70°C.
(d): After starting cooling of (c), components 25 to 37 were sequentially added at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsified beauty essence.

The all-in-one gel of Example 17 was an external composition for skin with excellent whitening effect, stickiness, crystal precipitation suppressing effect, and long-term stability.

Example 18: Oil-in-water emulsified beauty essence (multiple extract-containing beauty essence)
(Component) (% by mass)
1.1,3-butylene glycol 9.0
2. Diglycerin 5.0
3. Maltose 3.0
4. Purified water Appropriate amount5. Nicotinamide 4.0
6. Gellan gum *3 0.1
7. (Hydroxypropyl methylcellulose stearoxy ether *10 0.1
8. PEG-50 hydrogenated castor oil 2.0
9. dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) 2.0
10. Stearyl alcohol 1.0
11. Hydrogenated polyisobutene 3.0
12. Potassium cetyl phosphate *2 0.5
13. Sorbitan sesquioleate 0.8
14. Stearyl glycyrrhetinate 0.05
15. Tocopherol 0.1
16. Phenoxyethanol 0.2
17. Rose extract 0.01
18. Sakura extract 0.01
19. Lily extract 0.01
20. Shimahozuki extract 0.01
21. zedoary extract 0.01
22. Tea extract 0.01
23. Rhubarb extract 0.01
24. Angelica extract 0.01
25. Hibiscus extract 0.01
26. Tormentilla extract 0.01
27. Baobab extract 0.01
28. Ireisen extract 0.01
29. Sunflower extract 0.01
30. Kusuri extract 0.01
31. Glycyrrhiza extract 0.01
32. Safflower extract 0.01
33. Ginseng extract 0.01
34. Hatomugi extract 0.01
35. horsetail extract 0.01
36. Ginkgo biloba extract 0.01
37. Jojoba extract 0.01
38. Terminalia extract 0,01
39. Chickweed extract 0.01
40. Corn extract 0.01
41. Honeycomb extract 0.01
42. Pomegranate extract 0.01
43. Phellinus linteus extract 0.01
44. Rosehip extract 0.01
45. Evening primrose extract 0.01
46. Chamomile extract 0.01
47. Soybean extract 0.01
48. White bean extract 0.01
49. Mandarin orange extract 0.01
50. Magnolia extract 0.01
51. Black carrot extract 0.01
52. White strawberry extract 0.01
53. Himalayan raspberry extract 0.01
54. Silk tree extract 0.01
55. Sweet marjoram extract 0.01
56. Modama extract 0.01
57. Comfrey leaf extract 0.01
58. Saccharomyces/day lily flower fermentation liquid 0.01
59. Alpinia purpurea leaf extract 0.01
60. Murasakishibu fruit extract 0.01
61. Fucus extract 0.01
62. Hydrolyzed soy protein 0.01
63. Tabebuia impetiginosa bark extract 0.01
64. Glucosyl hesperidin 0.01

(Production method)
(a): Components 1 to 7 are uniformly dissolved and mixed at 70°C.
(b): Components 8 to 16 are uniformly dissolved and mixed at 80°C.
(c): Add (b) to (a) and emulsify at 70°C.
(d): After starting cooling of (c), components 17 to 64 were sequentially added at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsified beauty essence.

The oil-in-water emulsified beauty essence of Example 18 was a composition for external use on the skin that was excellent in whitening effect, stickiness, effect of suppressing crystal precipitation, and stability over time.

INDUSTRIAL APPLICABILITY The present invention can be applied to cosmetics, quasi-drugs, external preparations for skin, and the like.

Claims (4)

the following components (A) to (E);
(A) Nicotinamide: 1 to 10% by mass
(B) Anionic surfactant (C) Higher alcohol solid at 20°C (D) Gellan gum (E) Polyhydric alcohol: 5 to 25 mass%
An oil-in-water emulsion composition comprising: The blending mass ratio of component (E) and component (A) is
2. The oil-in-water emulsion composition according to claim 1, wherein (E)/(A)≧2. 2. The oil-in-water emulsion composition according to claim 1, further comprising (F) a water-soluble whitening agent. 4. The oil-in-water emulsion composition according to any one of claims 1 to 3, wherein the water-soluble whitening agent of component (F) is one or more selected from ascorbic acid derivatives and salts thereof, tranexamic acid, and arbutin.