JP2017081883A - External preparation for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external preparation for the skin which has excellent gloss feeling of the skin after use, excellent rich texture during use, non-stickiness and good sustainability of moisturizing feeling by using a combination of an oil-soluble chamomile extract and carnitines.SOLUTION: There is provided an external preparation for the skin which comprises the following components (A) to (D), wherein the mass content ratio [(C)/(D)] of the component (C) to the component (D) is 0.16 or more and 12 or less. (A) an oil-soluble chamomile extract, (B) a compound selected from carnitine, a derivative thereof and a salt thereof, (C) a silicone oil which is liquid at 25°C and (D) a fatty acid triglyceride in which one or more constituent fatty acids have 6 or more and 22 or less carbon atoms.SELECTED DRAWING: None

Description

  The present invention relates to an external preparation for skin.

  Oil-soluble chamomile extract has many effects such as photoaging inhibition, collagen production promotion, hair nourishing, ATP production promotion, skin barrier function improvement, cell differentiation promotion, collagen gel contraction promotion, pore contraction, etc. Since it has a physiological effect, it is blended in many cosmetics (for example, Patent Documents 1 to 4).

  Carnitines also have physiological effects such as a barrier function promoting action and an anti-aging improving action, and are therefore incorporated in many cosmetics (for example, Patent Documents 5 and 6).

JP-A-8-73324 JP-A-8-92056 Japanese Patent Laid-Open No. 10-72336 JP 2007-161666 JP 2012-206976 A JP 2013-139407 A

  However, when oil-soluble chamomile extract and carnitine are used in combination, if the oil agent is blended in a high amount to improve the feeling of use after use, such as the feeling of skin gloss and the feeling of use, the stability over time is seen. It was also found that there was a problem that it was difficult to obtain the intended glossiness and richness. Therefore, it has been necessary to improve them.

  Therefore, the present invention uses an oil-soluble chamomile extract and carnitines in combination, has excellent skin gloss after use and a rich feeling at the time of use, is not sticky, has a soft skin, and a long-lasting moisturizing feeling. The present invention relates to a skin external preparation.

  The present inventors have found that an external preparation for skin satisfying the above requirements can be obtained by containing silicone oil and a fatty acid triglyceride in a fixed ratio together with an oil-soluble chamomile extract and carnitines.

The present invention provides a skin external preparation containing the following components (A) to (D), wherein the content ratio [(C) / (D)] of the component (C) to the component (D) is 0.16 or more and 12 or less. It is to provide.
(A) Oil-soluble chamomile extract
(B) a compound selected from carnitine, derivatives thereof and salts thereof
(C) Silicone oil that is liquid at 25 ℃
(D) Fatty acid triglycerides in which one or more constituent fatty acids have 6 to 22 carbon atoms

  The topical skin preparation of the present invention uses an oil-soluble chamomile extract and carnitines in combination, has excellent skin gloss after use and a rich feeling during use, is not sticky, has soft skin, and maintains a moisturizing feeling. The property is also good.

[Component (A): Oil-soluble chamomile extract]
The oil-soluble chamomile extract of component (A) is obtained by extracting a flower of chamomile (Matricaria chamomilla L. (Compositae)), a asteraceae plant, with a lipophilic organic solvent. The solvent used is preferably an oil having a solubility parameter (SP value) in the range of 15 to 21, for example, isopropyl myristate (SP value 17.0), neopentyl glycol dicaprate (SP value 17.7), liquid paraffin (SP value) 16.4), squalane (SP value 16.2) and a mixture of two or more of these. These may be oils derived from plants such as sunflower oil, persic oil, soybean oil, sunflower oil, and the like. Generally, the type and amount of components contained in the extract vary depending on the oil used for extraction. In the present invention, an extract using squalane is preferable from the viewpoint of expressing a physiological effect such as a more excellent photoaging inhibition effect. Here, the SP value is a measure of compatibility between substances, and can be obtained by calculating Hansen's three-dimensional solubility parameter according to the method described in JP-A-10-194920.

  The oil-soluble chamomile extract can be produced, for example, by extracting from chamomile using a lipophilic organic solvent by the method described in JP-A-10-194920. Specifically, the extraction is performed by adding 1 to 100 times the lipophilic organic solvent to the crushed dried chamomile flower and stirring at 10 to 90 ° C. for 1 to 96 hours. The temperature can be appropriately set depending on the type of oil.

  In the present invention, the oil-soluble chamomile extract of component (A) may be in the form of a solution in which dry solids are dissolved in the extraction solvent in order to improve miscibility with other oily components during production. In this case, the dry solid content in the oil-soluble chamomile extract is preferably 0.01% by mass or more, more preferably 0.05% by mass, from the viewpoint of improving miscibility with other oily components during production and improving stability over time. % Or more, more preferably 0.08% by mass or more, further preferably 0.1% by mass or more, further preferably 0.2% by mass or more, and preferably 5% by mass or less, more preferably 2% by mass or less, still more preferably 1%. It is not more than mass%, more preferably not more than 0.8 mass%, still more preferably not more than 0.7 mass%.

  Here, the dry solid content is the solid content obtained by drying the extract to remove the solvent, and when the lipophilic organic solvent amount is known, it is the remaining amount excluding the lipophilic organic solvent amount.

  Such oil-soluble chamomile extract contains camazulene, umbelliferone, 7-methoxycoumarin, matricin, matricalin, taraxasterol, upole, apine, a spiro ether compound represented by the following formula, and the like.

  Among these components, it is considered that the content of the spiro ether compound causes physiological effects such as photoaging inhibition. In the present invention, the amount of the spiro ether compound in the oil-soluble chamomile extract is preferably 10 ppm or more, more preferably 100 ppm or more, from the viewpoint of expressing physiological effects such as photoaging inhibition action and improving stability over time. More preferably, it is 200 ppm or more, more preferably 300 ppm or more, more preferably 360 ppm or more, preferably 500 ppm or less, more preferably 480 ppm or less, further preferably 450 ppm or less, further preferably 440 ppm or less, further preferably 420 ppm or less. It is. In addition, one or more oil-soluble chamomile extracts can be used. When two or more oil-soluble chamomile extracts are used, it is preferable that the total amount of the spiro ether compound in the whole extract falls within the above range.

  The content of the component (A) in the external preparation for skin as a dry solid content is preferably 0.00004% by mass or more, more preferably from the viewpoint of expressing physiological effects such as photoaging inhibition and improving stability over time. Is 0.0002% by mass or more, more preferably 0.00032% by mass or more, further preferably 0.0004% by mass or more, more preferably 0.0008% by mass or more, and preferably 0.02% by mass or less, more preferably 0.008% by mass or less, Preferably it is 0.004 mass% or less, More preferably, it is 0.0032 mass% or less, More preferably, it is 0.0028 mass% or less.

  Furthermore, from the same viewpoint, the content as the spiro ether compound in the external preparation for skin is preferably 0.0375 ppm or more, more preferably 0.1875 ppm or more, further preferably 0.3 ppm or more, more preferably 0.375 ppm or more, Preferably, it is 0.75 ppm or more, preferably 18.75 ppm or less, more preferably 7.5 ppm or less, further preferably 3.75 ppm or less, still more preferably 3 ppm or less, and further preferably 2.625 ppm or less.

[Component (B): Compound selected from carnitine, derivatives thereof and salts thereof]
Component (B) is a compound selected from carnitine, derivatives thereof and salts thereof (sometimes referred to as carnitines). As these carnitines, derivatives thereof or salts thereof, carnitine represented by the following general formula (1) or (2), acylcarnitine, or those thereof from the viewpoint of good bioactive function strength and stability over time Salts are preferred.

[Wherein, R ¹ represents a hydrogen atom or an acyl group having 1 to 8 carbon atoms, and X ⁻ represents an anion. ]

Among R ^1, the number of carbon atoms of the acyl group is preferably 1 to 6, more preferably 2 to 4, and more preferably 2 acetyl groups from the viewpoint of developing a physiologically active function and improving the temporal stability in the preparation. Is more preferable.

Examples of X ⁻ in the general formula (2) include chloride, sulfonate, nitrate, acetate, citrate, nicotinate, salicylate and the like. From the viewpoint of reducing skin irritation, one kind selected from chloride, sulfonate and nitrate Or 2 or more types are preferable and 1 type or 2 types selected from a chloride and a sulfonate are more preferable. In addition, it is preferable that X ⁻ includes chloride.

Specific examples of the component (B) include carnitine (chemical name: 4-trimethylammonio-3-hydroxybutyric acid) in which R ¹ is a hydrogen atom in the general formula (1); R ¹ in the general formula (2) A carnitine salt that is a hydrogen atom; in general formula (1), R ¹ is an acyl group octanoylcarnitine, hexanoylcarnitine, valerylcarnitine, butyrylcarnitine, propionylcarnitine, acetylcarnitine, etc .; in general formula (2) , R ¹ is an acyl group octanoylcarnitine salt, hexanoylcarnitine salt, valerylcarnitine salt, butyrylcarnitine salt, propionylcarnitine salt, acetylcarnitine salt and the like.

  Component (B) includes D-form and L-form as stereoisomers, and DL-form is known as a mixture. From the viewpoint of the strength of bioactive function, L-form and DL-form are preferred, The body is more preferred.

  Of these, L-carnitine, L-carnitine hydrochloride, L-carnitine sulfate, L-carnitine, L-carnitine, L-carnitine hydrochloride, L-carnitine hydrochloride, L-carnitine hydrochloride, L-carnitine hydrochloride, L-carnitine hydrochloride, Carnitine nitrate, acetyl-L-carnitine, acetyl-L-carnitine hydrochloride, acetyl-L-carnitine sulfate, acetyl-L-carnitine nitrate, acetyl-L-carnitine acetate, acetyl-L-carnitine citrate, acetyl-L One or more selected from -carnitine nicotinate and acetyl-L-carnitine salicylate are preferred, L-carnitine, L-carnitine hydrochloride, L-carnitine sulfate, L-carnitine nitrate, acetyl-L One or more selected from -carnitine, acetyl-L-carnitine hydrochloride, acetyl-L-carnitine sulfate and acetyl-L-carnitine nitrate More preferably, one or more selected from L-carnitine, L-carnitine hydrochloride and L-carnitine sulfate are more preferable, and one or two selected from L-carnitine and L-carnitine hydrochloride Species are more preferred. Further, L-carnitine hydrochloride is preferably contained as component (B).

  Component (B) can be used alone or in combination of two or more. The content of the component (B) in the external preparation for skin is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and still more preferably from the viewpoint of improving the durability of the moisturizing effect on the skin and suppressing stickiness. 0.08% by mass or more, more preferably 0.1% by mass or more, further preferably 0.2% by mass or more, preferably 5% by mass or less, more preferably 3% by mass or less, still more preferably 2% by mass or less, still more preferably Is 1.5% by mass or less, more preferably 1.3% by mass or less.

[Component (C): Silicone oil liquid at 25 ° C]
The silicone oil as component (C) is liquid at 25 ° C. Such a silicone oil is not particularly limited as long as it is used in ordinary cosmetics. For example, dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, octamethylcyclotetrasiloxane, methylhydrogenpolysiloxane, Examples include higher alcohol-modified organopolysiloxane. Of these, linear or branched dimethylpolysiloxane, methylphenylpolysiloxane, decamethylcyclopentasiloxane, and the like from the viewpoint of improving glossiness, suppressing stickiness, and improving the elongation at the time of coating. One or more selected from octamethylcyclotetrasiloxane is preferable, and one or more selected from linear or branched dimethylpolysiloxane and methylphenylpolysiloxane is more preferable. The component (C) preferably contains two types selected from linear or branched dimethylpolysiloxane and methylphenylpolysiloxane.

Examples of the silicone oil of component (C), to improve the feeling gloss, reducing the stickiness, from the viewpoint of improving stability over time, preferably kinematic viscosity at 25 ° C. is 0.5 mm ² / s or more, 1 mm ² / more preferably not more s or more, more preferably not more 1.5 mm ² / s or more, but preferably not more than 200000 mm ² / s, more preferably not more than 50000mm ² / s, 5000mm ² / Those having s or less are more preferred, and those having 1000 mm ² / s or less are more preferred.

  The kinematic viscosity at 25 ° C is measured using a capillary viscometer to measure the time during which a fixed volume of liquid flows through the capillary of the viscometer at 25 ° C under one atmospheric pressure. Is used to calculate. As the capillary viscometer, Ubbelohde or Canon-Fenske model is used.

<Calculation method of kinematic viscosity>
Kinematic viscosity (mm ² / s) = Outflow time (seconds) x Viscometer constant

  Commercially available products can be used, specifically, the silicone KF-96 series 1-100CS released by Shin-Etsu Chemical Co., Ltd., and the silicone SH200 Fluid series released by Toray Dow Corning. 1-100CS, 2-1184 Fluid, and 5A-100A of TSF451 series sold by Momentive Performance Materials Japan.

  Component (C) can be used alone or in combination of two or more. The content of the component (C) in the external preparation for skin is preferably 0.1% by mass or more, more preferably 0.18% by mass or more, and still more preferably 0.3% by mass from the viewpoint of improving glossiness and richness and suppressing stickiness. More preferably, it is 0.5% by mass or more, more preferably 0.8% by mass or more, and from the viewpoint of usability and stability, it is preferably 25% by mass or less, more preferably 20% by mass or less, still more preferably 12%. It is 7 mass% or less, More preferably, it is 4 mass% or less more preferably 7 mass% or less.

[Component (D): Fatty acid triglyceride in which one or more constituent fatty acids have 6 to 22 carbon atoms]
The skin external preparation of the present invention may further contain a fatty acid triglyceride having one or more constituent fatty acids having 6 to 22 carbon atoms as component (D). Among them, from the viewpoint of improving the stability of the preparation and improving the richness, moisturizing feeling, and softness of the skin, it is preferable that 2 or more of the constituent fatty acids have 6 to 22 carbon atoms. Those having 6 to 22 carbon atoms are more preferred.

  Specific examples of such fatty acid triglycerides include tri (capryl / capric acid) glyceryl, tri (capryl / caprin / myristin / stearic acid) glyceryl, glyceryl tri-2-ethylhexanoate, glyceryl tricaprylate, glyceryl triethylhexanoate, Glyceryl stearate, glyceryl triisostearate, glyceryl tripalmitate, glyceryl tri-2-heptylundecanoate, glyceryl tribehenate, glyceryl trimyristate, glyceryl trilaurate, glyceryl trioleate, glyceryl trilinoleate, glyceryl tripallate Is mentioned. These may be triglyceride fatty acid glyceryl, olive oil, medofoam oil, macadamia nut oil, rice bran oil, shea butter and other plant-derived fatty acid triglycerides.

  Among these, from the above viewpoint, glyceryl tri (capryl / caprin), glyceryl tri (capryl / caprin / myristin / stearic acid), glyceryl tribehenate, glyceryl tristearate, glyceryl triisostearate, glyceryl tripalmitate, One or more selected from glyceryl trimyristate, glyceryl trilaurate, glyceryl tri-2-ethylhexanoate, glyceryl trioleate, glyceryl tripalmitoleate, and glyceryl trilinoleate are preferred, and tri (capryl caprin (Myristin stearate) glyceryl, glyceryl triisostearate, glyceryl tripalmitate, glyceryl tri-2-ethylhexanoate, glyceryl trioleate, glyceryl tripalmitoleate One or more selected from ceryl and glyceryl trilinoleate are more preferable, and tri (capryl, caprin, myristic, stearic acid) glyceryl, glyceryl tripalmitate, glyceryl trioleate, glyceryl tripalmitoleate and trilinol One or more selected from glyceryl acid are more preferable. Examples of plant-derived fatty acid triglycerides containing these suitable fatty acid triglycerides include one or more selected from olive oil, macadamia nut oil, and shea butter.

  These fatty acid triglycerides can be used alone or in combination of two or more. The content of the component (D) in the external preparation for skin is preferably 0.1% by mass or more, more preferably 0.4% by mass or more, from the viewpoint of suppressing stickiness and improving the moisturizing feeling, softness of the skin, and richness. More preferably, it is 0.5% by mass or more, preferably 15% by mass or less, more preferably 10% by mass or less, and still more preferably 8% by mass or less.

  In addition, the mass ratio (C) / (D) of the component (C) to the component (D) improves the feeling of gloss, suppresses stickiness, and improves the moisturizing feeling, the softness of the skin, and the feeling of richness. 0.16 or more, preferably 0.18 or more, more preferably 0.2 or more, further preferably 0.3 or more, further preferably 0.4 or more, and 12 or less, preferably 8 or less, more preferably 5 or less, More preferably, it is 3.5 or less, More preferably, it is 3 or less.

[Component (E): Sugar alcohol]
The topical skin preparation of the present invention may further contain a sugar alcohol as component (E). Sugar alcohol is obtained by reducing sugar, and examples thereof include sorbitol, xylitol, erythritol, and maltitol. Among these, from the viewpoint of improving the sustainability of the moisturizing feeling and improving the softness of the skin, one or more selected from sorbitol and maltitol are preferable. Moreover, it is preferable that sorbitol is included as a component (E).

  These sugar alcohols can be used alone or in combination of two or more. From the above viewpoint, the content of sugar alcohol in the external preparation for skin is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, still more preferably 0.5% by mass or more, and preferably 5% by mass or less. More preferably, it is 3 mass% or less, More preferably, it is 1.5 mass% or less.

[Component (F): Ethanol]
The skin external preparation of the present invention may further contain ethanol as component (F). The content of ethanol in the external preparation for skin is preferably 0.5% by mass or more, more preferably 1% by mass or more, still more preferably 2% by mass or more, and still more preferably, from the viewpoint of suppressing stickiness and improving stability over time. It is 3% by mass or more, preferably 20% by mass or less, more preferably 15% by mass or less, still more preferably 12% by mass or less, and further preferably 10% by mass or less.

[Component (G): Ester oil other than component (D)]
The external preparation for skin of the present invention may contain an ester oil other than the component (D) as the component (G). From the viewpoint of improving glossiness, suppressing stickiness, improving the persistence of the moisturizing feeling, the softness of the skin, and the feeling of richness, those having a total carbon number of 10 to 90 are preferred, those having a total carbon number of 20 to 80 More preferred. From the above viewpoint, the solubility parameter δ of the polar oil is preferably in the range of 15 or more, 21 or less, more preferably 16 or more, further preferably 16.5 or more, more preferably 19.5 or less, still more preferably 18 or less. It is.

  Specifically, ethyl arachidonate, ethyl linolenate, isononyl isononanoate, octyl isopalmitate, isopropyl linoleate, octyl isopelargonate, oleyl linoleate, isotridecyl isononanoate, ethyl linoleate, isopropyl isostearate, isocetyl octanoate , Oleyl eicosanoate, isostearyl octoate, isodecyl pivalate, isodecyl isononanoate, erucyl eicosanoate, octyldodecyl oleate, isostearyl pivalate, isostearyl isostearate, isocetyl isostearate, isostearyl eicosanoate, octyldodecyl eicosanoate , Isopropyl oleate, octyldodecyl dimethyloctanoate, hexyldecyl dimethyloctanoate, oleate myristate , Stearyl eicosanoate, ethyl oleate, decyl oleate, isocetyl stearate, octyl stearate, octyldodecyl stearate, isostearyl palmitate, isocetyl palmitate, octyl palmitate, isostearyl myristate, isocetyl myristate, myristine Isotridecyl acid, octyldodecyl myristate, isostearyl laurate, hexyl isostearate, myristyl isostearate, lauryl isostearate, stearyl oleate, cetyl oleate, isobutyl stearate, isobutyl palmitate, isopropyl palmitate, octyl myristate, laurin Isodecyl acid, butyl isostearate, octyl pelargonate, isopropyl myristate, laur Isoamyl laurate, isohexyl laurate, myristyl neopentanoate, isobutyl pelargonate, lauryl palmitate, decyl myristate, ethyl stearate, ethyl palmitate, butyl myristate, ethyl laurate, methyl myristate, methyl laurate, dinonanoic acid Propylene glycol, diisopropyl sebacate, diisobutyl adipate, neopentyl glycol dicaprate, propylene glycol dicaprate, dihexyl adipate, diisopropyl adipate, diglyceryl triisostearate, diethyl sebacate, diglyceryl monoisostearate, adipine Butyl acrylate, dibutyl adipate, diisostearyl malate, octyl oxystearate, octyl methoxycinnamate Octyldodecyl lactate, isostearyl lactate, oleyl lactate, methyl ricinoleate, octyl paradimethylaminobenzoate, myristyl lactate, dl-α-tocopherol, dl-α-tocopherol nicotinate, lauryl lactate, monomyristate monoisostearate And diglyceryl. Among these, from the above viewpoint, one or more selected from neopentyl glycol dicaprate, octyldodecyl myristate, and isocetyl myristate are preferable.

  Any of these ester oils other than component (D) can be used alone or in appropriate combination of two or more. The content of the component (G) in the external preparation for skin is preferably 0.1% by mass or more, more preferably 0.5% by mass or more, and more preferably 0.5% by mass or more, from the viewpoint of improving the stability of the preparation, suppressing stickiness, and improving glossiness. Preferably it is 1 mass% or more, Preferably it is 10 mass% or less, More preferably, it is 8 mass% or less, More preferably, it is 5 mass% or less.

[Component (H): Hydrocarbon]
The skin external preparation of the present invention may further contain a hydrocarbon as component (H). Such hydrocarbons are not limited as long as they are usually used in cosmetics. For example, α-olefin oligomer, liquid paraffin, light isoparaffin, light liquid isoparaffin, liquid isoparaffin (fluid polyisobutylene), heavy fluid Examples thereof include linear or branched hydrocarbon oils such as isoparaffin, squalane and squalene. Any of these liquid hydrocarbons can be used alone or in appropriate combination of two or more. Among these, from the viewpoint of improving skin finish and stability over time, one or two selected from α-olefin oligomer, light isoparaffin, light liquid isoparaffin, liquid isoparaffin, heavy liquid paraffin, liquid paraffin and squalane More preferably, one or more selected from α-olefin oligomer, light isoparaffin, light liquid isoparaffin, liquid isoparaffin, liquid paraffin and squalane, α-olefin oligomer, light isoparaffin, light liquid isoparaffin, One or more selected from liquid isoparaffin and squalane are more preferable.

  The content of the component (H) in the external preparation for skin is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and further preferably from the viewpoint of improving the stability of the preparation and improving the softness of the skin. It is 0.3% by mass or more, preferably 3% by mass or less, more preferably 2% by mass or less, and still more preferably 1% by mass or less.

  Moreover, the content ratio [(C) / ((B) + (H))] of the component (C) with respect to the sum of the component (B) and the component (H) improves glossiness, suppresses stickiness, From the viewpoint of improving the moisturizing feeling, softness of the skin, and richness, it is preferably 0.6 or more, more preferably 0.8 or more, further preferably 1.5 or more, and preferably 21 or less, more preferably 16 or less, still more preferably. Is 12 or less, more preferably 6 or less, and still more preferably 5 or less.

[Ingredient (I): Water]
The skin external preparation of the present invention contains water as component (I). The content of component (I) in the external preparation for skin is preferably 50% by mass or more, more preferably 60% by mass or more, and 70% by mass from the viewpoint of reducing stickiness, improving moisturizing feeling and softness of the skin. The above is more preferable, 92 mass% or less is preferable, 88 mass% or less is more preferable, and 85 mass% or less is still more preferable. Specifically, it is preferably 50 to 92% by mass, more preferably 60 to 88% by mass, and still more preferably 70 to 85% by mass.

[Other optional ingredients]
The skin external preparation of the present invention includes surfactants, water-soluble polymers, polyhydric alcohols other than component (E), higher alcohols, UV absorbers, UV scattering agents, sequestering agents, neutralizing agents, pH adjustment Various raw materials usually used in cosmetics such as agents, antioxidants, antibacterial agents, antiperspirants, drugs, various extracts and fragrances can be contained. Each of these agents is not limited to the use as each agent. Depending on the purpose, for example, an antiperspirant may be used as a fragrance, or as a combination with other uses, for example, an antiperspirant. And can be used as an effect as a fragrance.

  As the surfactant, known ones such as an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be used, but they are low in irritation, excellent in emulsion stability, and more sticky. A nonionic surfactant is preferable from the viewpoint of less elongation and better elongation on the skin.

  Nonionic surfactants include, for example, polyoxyethylene glycol type nonions such as polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, etc. Surfactant, glycerin fatty acid ester, polyglycerin fatty acid ester, mono fatty acid sorbitan such as sorbitan monostearate, sucrose fatty acid ester and the like.

  Among these, from the same viewpoint, one or more selected from polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and mono fatty acid sorbitan are more preferable. Moreover, it is preferable that polyoxyethylene hydrogenated castor oil is included as a nonionic surfactant.

  The number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is preferably 25 to 70, more preferably 30 to 60, from the viewpoint of excellent emulsification stability, less stickiness, and better elongation on the skin. 40-60 is more preferable. Specifically, the polyoxyethylene hydrogenated castor oil preferably contains one or two selected from polyoxyethylene (40) hydrogenated castor oil and polyoxyethylene (60) hydrogenated castor oil.

  The content of the surfactant in the external preparation for skin is preferably 0.01% by mass or more, preferably 0.1% by mass from the viewpoint of low irritation, excellent emulsification stability, less stickiness, and better elongation on the skin. The above is more preferable, 0.5% by mass or more is further preferable, 3% by mass or less is preferable, 2% by mass or less is more preferable, and 1.5% by mass or less is more preferable.

  Examples of the water-soluble polymer include water-soluble cationic polymers, anionic polymers, nonionic polymers, amphoteric polymers, and bipolar polymers.

  Specific examples of the cationic polymer include hydroxyethyl cellulose (polyquaternium-10) having an O- [2-hydroxy-3- (trimethylammonio) propyl] group and (vinylpyrrolidone-dimethylaminomethylethyl methacrylate). Examples thereof include a polymer diethyl sulfate (polyquaternium-11) and a methylvinylimidazolium chloride / vinylpyrrolidone copolymer.

  Specific examples of the anionic polymer include carboxyvinyl polymer, carboxymethylcellulose, carrageenan, xanthan gum, polystyrene sulfonate, agar, gatch gum, caraya gum, pectin, alginate salt, and also acrylic acid / alkyl methacrylate copolymer (acrylic). Acid Na / acryloyldimethyltaurine Na) copolymer, hyaluronic acid or alkali metal salts thereof.

  Specific examples of nonionic polymers include cellulose ethers (hydroxybutylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylhydroxyethylcellulose, hydroxyethylcellulose, etc.), propylene glycol alginate, polyacrylamide, poly (ethylene oxide) , Polyvinyl alcohol, polyvinyl pyrrolidone, amylose, hydroxyethyl amylose, and mixtures thereof.

  Specific examples of the amphoteric polymer or the bipolar polymer include octylacrylamide / acrylate / butylaminoethyl methacrylate copolymer, polyquaternium-47, and polyquaternium-43.

  These can be used alone or in appropriate combination of two or more. Carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, xanthan gum, hydroxypropyl methylcellulose, polyacrylamide, (Na acrylate / acryloyl dimethyl taurine) from the viewpoint of suppressing stickiness and improving the durability of moisturizing effect and stability over time Na) copolymer and one or more selected from hyaluronic acid or alkali metal salts thereof are preferable, and one or more selected from carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer and xanthan gum Are more preferable, and 2 or 3 types selected from carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer and xanthan gum are still more preferable.

  From the above viewpoint, the content of the water-soluble polymer in the external preparation for skin is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, and preferably 3% by mass or less. 1 mass% or less is more preferable, and 0.7 mass% or less is still more preferable.

  Examples of the polyhydric alcohol other than the component (E) include divalent to tetravalent polyhydric alcohols. Specifically, glycols such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol, 1,3-butylene glycol; glycerin, diglycerin, polyglycerin; sorbitol And sugars such as maltitol. These polyhydric alcohols can be used alone or in combination of two or more.

  Among these, ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin are used from the viewpoint of suppressing creaking and stickiness, improving skin softness, and improving stability over time. 1 type or 2 types or more selected from sorbitol and maltitol are preferable, 1 type or 2 types selected from propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, sorbitol and maltitol The above are more preferable, and one or more selected from dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, sorbitol and maltitol are more preferable.

  From the above viewpoint, the content of the polyhydric alcohol in the external preparation for skin is preferably 1% by mass or more, more preferably 1.5% by mass, more preferably 10% by mass or less, and even more preferably 8% by mass or less.

  Examples of the higher alcohol include saturated or unsaturated linear or branched alcohols represented by the formula ROH (where R is a linear or branched alkyl or alkenyl group having 16 to 24 carbon atoms). The higher alcohol has a carbon number of preferably 16 or more, more preferably 18 or more, and still more preferably 21 from the viewpoint of improving the stability over time, improving the richness, and improving the durability of the moisturizing feeling. Or more, preferably 24 or less, more preferably 23 or less. Further, from the viewpoint of improving the stability of the preparation and improving the sustainability of a rich feeling and a moisturizing feeling, a linear alcohol is preferable.

  Specific examples include cetyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, carnervir alcohol and the like, and any of them can be used alone or in combination of two or more. Of these, one or more selected from stearyl alcohol, aralkyl alcohol and behenyl alcohol are preferred from the viewpoints of improving stability over time, improving glossiness, and improving the richness and moisturizing feeling. 1 type or 2 types selected from alcohol and behenyl alcohol are more preferable. Moreover, it is preferable that behenyl alcohol is included as a higher alcohol.

  The content of the higher alcohol in the external preparation for skin is preferably 0.005% by mass or more, more preferably 0.06% by mass or more, from the viewpoint of improving glossiness, suppressing stickiness, improving richness and moisturizing feeling, More preferably, it is 0.05 mass% or more, More preferably, it is 0.1 mass% or more, More preferably, it is 0.2 mass% or more, Preferably it is 2 mass% or less, More preferably, it is 1.5 mass% or less, More preferably, it is 1 mass % Or less, more preferably 0.5% by mass or less.

Drugs include vitamin A oil, retinol, retinol palmitate, inosit, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, nicotinic acid dl-α-tocopherol, vitamin D ₂ (ergocaciferol), dl-α-tocopherol, Vitamins such as dl-α-tocopherol acetate, pantothenic acid and biotin; amino acids such as arginine, aspartic acid, tranexamic acid, cystine, cysteine, methionine, serine, leucine and tryptophan; anti-inflammatory agents such as allantoin and azulene; arbutin and the like Whitening agents; astringents such as zinc oxide and tannic acid; refreshing agents such as L-menthol and camphor and sulfur.

  In addition to being used in a free state, the drug can be used in the form of an acid or base salt and those having a carboxylic acid group can be used in the form of an ester.

  Various extract liquids include Dokudami Extract, Oat Extract, Merilot Extract, Oyster Extract, Licorice Extract, Peonies Extract, Soap Extract, Loofah Extract, Kina Extract, Yakinoshita Extract, Clara Extract, Kouhon Extract, Fennel Extract, Primrose Extract, Rose Extract , Ginger extract, Lemon extract, Shikon extract, Aloe extract, Ginger root extract, Eucalyptus extract, Horsetail extract, Sage extract, Thyme extract, Tea extract, Seaweed extract, Cucumber extract, Clove extract, Raspberry extract, Melissa extract, Carrot extract, Carrot extract , Horse chestnut extract, peach extract, peach leaf extract, mulberry extract, cornflower extract, cassava extract, placenta extract, thymus extract, silk extract, etc. .

  Furthermore, in the external preparation for skin of the present invention, an appropriate fragrance, pigment or the like can be added if necessary so long as the emulsion stability is not impaired.

  The skin external preparation of the present invention can be suitably used for cosmetics, pharmaceuticals, quasi drugs and the like. Specifically, facial cleansers, cleansing cosmetics, lotions, emulsions, beauty creams, base cosmetics, sunscreen cosmetics, packs, massage cosmetics, and other skin cosmetics; ointments containing various drugs, creams, etc. It can be suitably used as a medicine. In particular, since the external preparation for skin of the present invention does not have a sticky or slimy feeling, it can be suitably used as a skin cosmetic, preferably applied to the skin excluding the scalp, more preferably to any of the face, body, limbs, etc. By doing so, it can be used.

  The dosage form of the external preparation for skin of the present invention is arbitrary, and it is prepared as a liquid, emulsion, gel, spray, mousse, etc., but it gives a fresh feel and has a good elongation at application, An external preparation for emulsified skin is preferable, and an oil-in-water type external preparation for skin emulsification is more preferable.

〔Production method〕
The external preparation for skin of the present invention can be produced by a predetermined procedure depending on the form. For example, the method for producing an external preparation for skin of the present invention may include a step of mixing components (A) to (I) together.
Further, the method for producing an external preparation for skin of the present invention comprises the step 1 of heating and stirring the aqueous phase containing the component (B), the component (E), the component (F) and the component (I);
Step 2 of heating and stirring the oil phase containing component (A), component (C), component (D), component (G) and component (H);
You may include the process 3 which mixes the preparation of the process 1 and the preparation of the process 2.

  The heating temperature in step 1 is preferably 50 ° C. or higher, more preferably 55 ° C. or higher, and preferably 90 ° C. or lower, more preferably from the viewpoint of sufficiently dissolving the water phase component without boiling water. 85 ° C or less.

  The heating temperature in step 2 is preferably 50 ° C. or higher, more preferably 55 ° C. or higher, and preferably 90 ° C. or lower, more preferably 85 ° C. or lower, from the viewpoint of sufficiently dissolving the oil phase component.

  In addition, the component (F) which is a component that easily volatilizes and the component (B) that is easily affected by heat are preferably added and mixed after an emulsion is formed in advance.

Specifically, the method for producing an external preparation for skin of the present invention comprises the step 1 of heating and stirring the aqueous phase containing the components (E) and (I),
Step 2 of heating and stirring the oil phase containing component (A), component (C), component (D), component (G) and component (H);
Step 3 of mixing the preparation of Step 1 with the preparation of Step 2;
Step 4 of cooling the preparation of step 3;
After the temperature of the preparation in step 4 has dropped below 50 ° C., step 5 may be added, in which component (B) and component (F) are added and mixed.

  The heating temperature in step 1 is preferably 50 ° C. or higher, more preferably 55 ° C. or higher, and preferably 90 ° C. or lower, more preferably from the viewpoint of sufficiently dissolving the water phase component without boiling water. 85 ° C or less.

  The heating temperature in step 2 is preferably 50 ° C. or higher, more preferably 55 ° C. or higher, and preferably 90 ° C. or lower, more preferably 85 ° C. or lower, from the viewpoint of sufficiently dissolving the oil phase component.

  In the case of using the component (B) that has not been neutralized in Step 5, from the viewpoint of maintaining a uniform mixed state, the component (B) is neutralized in advance and then added to the preparation of Step 4 and mixed. It is preferable to make it.

Examples 1-16 and Comparative Examples 1-7
According to the formulations shown in Tables 1 to 3, external preparations for skin (oil-in-water emulsions) were prepared.

(Production method)
A: Ingredient 2 is dissolved in a part of ingredient 28 (10 parts by mass of ingredient 2), and a part of ingredient 27 (0.5 parts by weight of ingredient 2) is added thereto and neutralized.
B: Components 1, 3 to 13, and 17 to 20 are mixed with stirring under heating at 80 ° C.
C: Components 14, 15, 21 to 24, component 25 and component 26 previously swollen with purified water, and the remaining component 28 are stirred and mixed under heating at 80 ° C.
D: The preparation of Step B is added to the preparation of Step C, and the mixture is uniformly stirred and mixed using a homomixer (7000 rpm, 10 minutes) under heating at 80 ° C.
E: Start cooling F: When the temperature of the preparation of Step D drops to 50 ° C., add the remaining component 26 and stir and mix uniformly with a homomixer (2000 rpm, 2 minutes).
G: When the temperature of the preparation of Step F is lowered to 40 ° C., add the component 16, the preparation of Step A, and further uniformly stir and mix with a homomixer (3500 rpm, 10 minutes).
H: When the temperature of the preparation of Step G is lowered to 35 ° C., the cooling is finished and the product is naturally cooled.

  Using these samples, sensory evaluation was performed according to the following criteria for the following evaluation items, and the results are also shown in Tables 1 to 3.

(sensory evaluation)
10 expert evaluation panelists asked to use the sample, and immediately after use, evaluated the questionnaire on “Improvement of glossiness”, “No stickiness”, “Improvement of skin softness”, “Improvement of body feel” 1 hour after use of the sample, a questionnaire evaluation was performed on “sustainability of moisture retention”. Sensory evaluation was performed according to the following criteria. The evaluation represented the average score (rounded to the first decimal place).

Improved glossiness (criteria)
5 points: Very good.
4 points: Good.
3 points: Somewhat good.
2 points: Bad.
1 point: Very bad.

No stickiness (criteria)
5 points: Very good.
4 points: Good.
3 points: Somewhat good.
2 points: Bad.
1 point: Very bad.

Persistence of moisturizing feeling (criteria)
5 points: Very good.
4 points: Good.
3 points: Somewhat good.
2 points: Bad.
1 point: Very bad.

Improvement of skin softness (criteria)
5 points: Very good.
4 points: Good.
3 points: Somewhat good.
2 points: Bad.
1 point: Very bad.

Improvement of body feeling (criteria)
5 points: Very good.
4 points: Good.
3 points: Somewhat good.
2 points: Bad.
1 point: Very bad.

* 1: Squalane extract, dry solid content 0.4% by mass, spiro ether compound 370ppm
* 2: KF-96A-100cs, manufactured by Shin-Etsu Chemical Co., Ltd.
* 3: FZ-209, manufactured by Toray Dow Corning
* 4: KF-995, manufactured by Shin-Etsu Chemical Co., Ltd.
* 5: SH 244 FLUID, manufactured by Toray Dow Corning
* 6: KF-96A-100000cs, manufactured by Shin-Etsu Chemical Co., Ltd.
* 7: Saracos 334, manufactured by Nisshin Oillio Group
* 8: PEMULEN TR-1, manufactured by Lubrizol Advanced Materials
* 9: Shintalen L, manufactured by Wako Pure Chemical Industries, Ltd.

  Hereinafter, the formulation example of this invention is shown. Both have the same effects as the embodiment.

Formulation Example 1 (oil-in-water emulsion)
Component Content (mass%)
Oil-soluble chamomile extract (* 1) 0.5
L-carnitine chloride 0.5
Methylphenyl polysiloxane (* 3) 2.5
Cetanol 0.3
Behenyl alcohol 0.1
Olive oil 0.5
Macadamia nut oil 0.5
Tri (Capryl / Caprin / Myristine / Stearic acid) Glyceryl (* 7) 1.0
Ethanol 7.0
Maltitol (75% by weight aqueous solution) 1.5
Concentrated glycerin 2.0
Polyoxyethylene (60) hydrogenated castor oil 1.0
Neopentyl glycol dicaprate 3.0
Carboxyvinyl polymer (* 9) 0.2
Xanthan gum 0.1
Sodium hyaluronate (* 10) 0.01
Potassium hydroxide appropriate amount soymilk fermentation broth (* 11) 0.1
Clove extract (* 12) 0.1
Himefuuro extract (* 13) 0.1
Coral grass extract (* 14) 0.1
HIMENO button extract (* 15) 0.1
Edetate 0.02
Phenoxyethanol 0.5
Water remaining

* 1, * 3, * 7, * 9 are the same as Table 1, Table 2, and Table 3.
* 10: Hyaluronic acid FCH-120, manufactured by Kikkoman Biochemifa
* 11: Fermented soymilk, manufactured by Sansho Pharmaceutical Co., Ltd.
* 12: Falco Rex Chouji, made by Ichimaru Falcos
* 13: Princess care, manufactured by Ichimaru Falcos
* 14: Coral glass, manufactured by Technoble
* 15: Snapper extract BG70, manufactured by Maruzen Pharmaceutical Co., Ltd.

Formulation Example 2 (Gel Cream)
Component Content (mass%)
Oil-soluble chamomile extract (* 1) 0.5
L-carnitine chloride 0.5
Methylphenyl polysiloxane (* 3) 3.5
Methyl polysiloxane (100mm ² / s) (* 2) 1.5
Cetanol 0.6
Stearyl alcohol 0.4
Olive oil 1.5
Macadamia nut oil 0.5
Tri (Capryl / Caprin / Myristine / Stearic acid) Glyceryl (* 7) 1.0
Ethanol 7.0
Sorbitol (70% by weight aqueous solution) 1.5
Polyoxyethylene (60) hydrogenated castor oil 1.0
Neopentyl glycol dicaprate 3.0
Carboxyvinyl polymer (* 9) 0.4
Xanthan gum 0.1
Sodium hyaluronate (* 10) 0.01
Potassium hydroxide appropriate amount soymilk fermentation broth (* 11) 0.1
Clove extract (* 12) 0.1
Yuzu extract (* 16) 0.1
Rosemary extract (* 17) 0.1
Green tea extract (* 18) 0.1
Edetate 0.02
Phenoxyethanol 0.5
Water remaining

* 1, * 2, * 3, * 7, * 9 are the same as Table 1, Table 2, and Table 3, and * 10, * 11, * 12 are the same as Formulation Example 1.
* 16: Yuzu extract Maruzen Pharmaceutical Co., Ltd.
* 17: Mannen wax extract manufactured by Koei Kogyo Co., Ltd.
* 18: Green tea extract BGW Maruzen Pharmaceutical Co., Ltd.

Claims (4)

A skin external preparation containing the following components (A) to (D), wherein the mass ratio [(C) / (D)] of the component (C) to the component (D) is 0.16 or more and 12 or less.
(A) Oil-soluble chamomile extract
(B) a compound selected from carnitine, derivatives thereof and salts thereof
(C) Silicone oil that is liquid at 25 ℃
(D) Fatty acid triglycerides in which one or more constituent fatty acids have 6 to 22 carbon atoms   The skin external preparation according to claim 1, wherein the content ratio [(C) / (D)] of the component (C) to the component (D) is 0.18 or more and 8 or less.   The skin external preparation according to claim 1 or 2, wherein the content of the component (A) as a dry solid content is 0.00004% by mass or more and 0.02% by mass or less.   It is an oil-in-water type emulsified skin external preparation, The skin external preparation of any one of Claims 1-3.