JP2002212009A - Antifungal agent and antimicrobial low-irritative cosmetic comprising the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an antifungal agent having high safety without being affected by pH or other formulation ingredient and obtain an antimicrobial low-irritative cosmetic exhibiting sufficient antimicrobial activity, having high safety and having not only low irritation to skin, but also free from uncomfortable feeling even when used. SOLUTION: This antifungal agent comprises one or two or more kinds of compounds selected from an acylcarnitine represented by formula (1) and its salt. This antimicrobial low-irritative cosmetic comprises the above antifungal agent and (A) one or two or more kinds of compounds selected from a group consisting of para-oxybenzoic acid ester, phenoxyethanol, light-sensitive element No. 101, light-sensitive element No. 201, light-sensitive element No. 401, hinokithiol, N-long-chain acyl basic amino acid derivative and its acid addition salt and/or (B) one or two or more kinds of antimicrobial plant extracts.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an antifungal agent having excellent antifungal activity, and a cosmetic composition comprising the antifungal agent in combination with a specific antibacterial substance, which has low irritation to the skin and excellent antibacterial activity. About.

[0002]

2. Description of the Related Art Conventionally, various antibacterial and fungicides have been used in pharmaceuticals, cosmetics, foods, and the like in order to prevent contamination by microorganisms such as bacteria, molds, and yeasts during production and use. . Examples of such fungicides and fungicides include benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, dehydroacetic acid and its salts, paraoxybenzoic acid esters, resorcinol, isopropylmethylphenol, benzalkonium chloride, hydrochloric acid Chlorhexidine, chlorhexidine gluconate, trichlorocarbanilide, photosensitive element 201, phenoxyethanol, trichlorohydroxydiphenyl ether, and the like are used.

[0003] The amount of the fungicide and fungicide is regulated by the Japanese Pharmacopoeia, the standard of cosmetic raw materials, the official standard of food additives, etc. from the viewpoint of safety. However, among these fungicides, those that do not show sufficient antibacterial activity against fungi such as mold, those that only show an effect on the acidic side, and that are inactivated by nonionic surfactants In some cases, sufficient antibacterial activity was not obtained when blended in preparations. In addition, when formulated in a skin external preparation,
Even though they did not show a primary irritative or sensitizing response to the skin, they often caused discomfort such as stabbing pain, burning, and tingling during use.

[0004]

Therefore, according to the present invention, without being affected by pH or other components,
Obtaining a highly safe antifungal agent, and exhibiting sufficient antibacterial activity, showing high safety, not only being less irritating to the skin, but also causing the above-mentioned discomfort during use The aim was to obtain an antibacterial and hypoallergenic cosmetic without any.

[0005]

As a result of various studies to solve the above problems, the present inventors have found an excellent antifungal activity of acylcarnitine having an acyl group having a specific chain length and a salt thereof. By using acylcarnitines in combination with a specific antibacterial substance, it is possible to obtain an antibacterial hypoallergenic cosmetic which exhibits sufficient antibacterial activity, is hypoallergenic to the skin, and does not cause discomfort when used. They have found what they can do and have completed the present invention.

That is, in the present invention, one or more of the acylcarnitines represented by the formula (1) and salts thereof may be used as they are, or various carriers such as water, lower alcohols, emulsions, microcapsules, etc. To form an antifungal agent, and one or more of the above antifungal agents, and (A) paraoxybenzoate,
Phenoxyethanol, Photosensitive element 101, Photosensitive element 201
No., photosensitizer No. 401, hinokitiol, one or more compounds selected from N- long chain acyl basic amino acid derivative and the group consisting of an acid addition salt thereof, and / or (B) Ginkgo (Ginkgo) genus Sasa ( Sasa ) genus, Juzudama ( Coix )
Genus, genus Asiaarum , Hypericum ( Hyper
icum ), Birch ( Betula ), Rabbit ( Arnic )
a ) genus, chamomile ( Matricaria ), mugwort ( Artemisi
a) species, burdock (Arctium) genus, calendula (Calendul
a) species, knapweed (Centaurea) genus, Roman chamomile (Anthemis) genus Coptis (Coptis) genus, laurel (Laurus) genus, mulberry (Morus) genus, Humulus lupulus (Humul
us ) genus, wild mint ( Isodon ) genus, skullcap ( Scut )
ellaria) genus Salvia (Salvia) genus, shiso (Perilla)
Genus, Ibuki thyme (Thymus) species, mint (Menth
a ) Genus, genus Melissa, genus Rosmarinus , lavender ( Lavandula ), linden ( Tilia ), genus Lonicera, genus Foeniculum, genus Cnidium , Thea sinensis L.), Houttuynia
Genus, horse chestnut (Aesculus) genus, cherry (Prunus) the genus, rose (Rosa) genus, Burnet (Sanguisorba) genus, pigweed (A
genus maranthus, genus Geranium, genus Syzygium, genus Paeonia , licorice ( Gly
cyrrhiza) genus Sophora (Sophora) genus, witch hazel (Ham
amelis) species, yellowfin tuna (Phellodendron) genus, pepper (Zanthoxylum) genus, purple (Lithospermum) genus, comfrey (Symphytum) genus, forsythia (Forsythia)
The cosmetic base contains an extract of one or more plants selected from the group consisting of plants belonging to the genera, Aloe , and Polygonatum .

Embedded image (In the formula, R ¹ represents an alkyl group or an alkenyl group having a straight or branched chain having 9 to 16 carbon atoms).

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, as shown in the formula (1), an acylcarnitine having a saturated or unsaturated acyl group having 10 to 17 carbon atoms and having a linear or branched chain, And its salts.

Embedded image (In the formula, R ¹ represents an alkyl group or an alkenyl group having a straight or branched chain having 9 to 16 carbon atoms).

Examples of such acylcarnitines include O-decanoyl (caprinoyl) carnitine, O-undecanoyl carnitine, O-dodecanoyl (lauroyl) carnitine, O-tridecanoyl carnitine, O-tetradecanoyl (myristoyl) carnitine, O -Pentadecanoylcarnitine, O-hexadecanoyl (palmitoyl) carnitine, O-heptadecanoyl (margaroyl) carnitine,
O-12-methyltridecanoylcarnitine, O-14-methylpentadecanoyl (isopalmitoyl) carnitine, O-2-
Decenoylcarnitine, O-4-decenoylcarnitine, O-
9-decenoyl (caproleil) carnitine, O-9-undecenoyl (9-undecinoyl) carnitine, O-10-undecenoyl (10-undecinoyl) carnitine, O-2-dodecenoyl (2-lauroreyl) carnitine, O-3-dodecenoyl ( Linderoyl) carnitine, O-4-dodecenoylcarnitine, O-5-dodecenoyl (5-lauroreyl) carnitine, O-11-dodecenoyl (11-lauroleyl) carnitine, O-2-tridecenoylcarnitine, O-cis -9-tridecenoylcarnitine, O-12-tridecenoylcarnitine, O-4-tetradecenoylcarnitine, O-5-tetradecenoyl (5-myristoyl) carnitine, O-9-tetradecenoyl (9-myristoyl ) Carnitine, O-6-pentadecenoylcarnitine, O-cis-9-pentadecenoylcarnitine, O-14-pentadecenoylcarnitine, O-2-hexade Octanoyl (2-palmitoleyl) carnitine, O-cis-
7-hexadecenoyl (7-palmitrail) carnitine,
O-cis-9-hexadecenoyl (cis-9-palmitoleyl) carnitine, O-trans-9-hexadecenoyl (trans-9-palmitoleyl) carnitine, O-2-heptadecenoyl carnitine, O-cis-7- Heptadecenoylcarnitine, O-cis-8-
Examples include heptadecenoylcarnitine, O-cis-9-heptadecenoylcarnitine and the like, and any of D-form, L-form and DL-form may be used.

The above-mentioned long-chain acylcarnitines used in the present invention can be prepared by the Schotten-Baumann method or the modified Schotten-Baumann method because of the low solubility of carnitine in organic solvents and the low reactivity of secondary hydroxyl groups of carnitine. -Baumann
Although it is difficult to synthesize by a general esterification method such as a method or a transesterification reaction with long-chain fatty acid methyl, carnitine is dissolved in trichloroacetic acid and reacted with an acid chloride in the solution. Thus, a good yield can be obtained.

The acyl carnitine salts usable in the present invention include inorganic acid salts such as hydrochloride, glycolate, acetate, lactate, pyrrolidone carboxylate, and the like.
Organic acid salts such as citrate, aspartate and glutamate can be mentioned. In consideration of solubility in an aqueous base, it is preferable to use a hydrochloride or an acetate.

In the present invention, one or more of the above-mentioned acylcarnitines and salts thereof are selected, and they are used as they are or contained in various carriers such as water, lower alcohols, emulsions, microcapsules and liposomes. Antifungal agent.

Further, in the present invention, one or more kinds selected from the above-mentioned antifungal agents, one or more kinds of antibacterial substances selected from the following group (A), and / or (B) One or two or more antibacterial plant extracts selected from the group are contained in a cosmetic base to obtain an antibacterial hypoallergenic cosmetic.

The antibacterial substances of the group (A) are paraoxybenzoate, phenoxyethanol, photosensitizer 101
No. 201, No. 201, No. 401, hinokitiol, N-long-chain acyl basic amino acid derivatives and their acid addition salts.

Examples of the paraoxybenzoic acid ester include methyl paraoxybenzoate, ethyl paraoxybenzoate,
Propyl paraoxybenzoate, butyl paraoxybenzoate and the like are mentioned, and as phenoxyethanol, 2-phenoxyethanol is suitably used. Hinokitiol is 4-isopropyltropolone. For these, those commercially available as raw materials for pharmaceuticals and cosmetics can be used.

Photosensitizer No. 101 is 2,2 '-[3'-[2- (3
-Heptyl-4-methyl-2-thiazoline-2-ylidene) ethylidene] propenylene] bis [3-heptyl-4-methyl] thiazolinium, which is provided under the component names or trade names such as platonin and NK19. Photosensitizer 201 is 2- [2- (3-heptyl-4-methyl-2-thiazoline-2-ylidene) methine] -3-heptyl-4-methylthiazolinium iodide, pionin, NK266 Etc. are provided by component names or trade names. In addition, Photosensitive Element 401 has 2- (2-
Anilinovinyl) -3,4-dimethyloxazolinium, which is provided under a component name such as Luminex, NK355 or the like.

As the N-long-chain acyl basic amino acid derivatives, those represented by the formulas (2) to (4) can be used. These acid addition salts include hydrochloride, acetate, lactate, and the like. DL
-Pyrrolidone carboxylate and the like.

Embedded image

Embedded image

Embedded image[In the formulas (2) to (4), R²Is a straight chain having 5 to 25 carbon atoms
Alkyl or alkenyl group having a branched or branched chain, R
³Is hydrogen or a hydroxyl group, and X is NH₂Or OR⁴, R ⁴Is charcoal
A linear or branched alkyl group having a prime number of 1 to 6, or
Alkenyl group or phenyl group or benzyl group, formula
In (3), n is 3 or 4. ]

Specifically, N-caproyl-L or DL-arginine, N-capryloyl-L or DL-arginine, N-caprynoyl-L or DL-arginine, N-undecanoyl-L or DL-arginine, N- Lauroyl-L or DL-arginine,
N-myristoyl-L or DL-arginine, N-palmitoyl-
L or DL-arginine, N-stearoyl-L or DL-arginine, N-araquinoyl-L or DL-arginine, N-behenoyl-L or DL-arginine, N-coconut fatty acid acyl-L or DL-arginine, N -Isopalmitoyl-L or DL-arginine, N-isostearoyl-L or DL-arginine, N-oleoyl-L or DL-arginine, N-caproyl-L or DL-
Ornithine, N-capryloyl-L or DL-ornithine, N-
Caprinoyl-L or DL-ornithine, N-undecanoyl-
L or DL-ornithine, N-lauroyl-L or DL-ornithine, N-myristoyl-L or DL-ornithine, N-palmitoyl-L or DL-ornithine, N-stearoyl-L or DL-ornithine, N-araquinoyl- L or DL-ornithine, N-behenoyl-L or DL-ornithine, N-coconut fatty acid acyl-
L or DL-ornithine, N-isopalmitoyl-L or DL-ornithine, N-isostearoyl-L or DL-ornithine, N
-Oleoyl-L or DL-ornithine, N-caproyl-L or
DL-lysine, N-capryloyl-L or DL-lysine, N-caprynoyl-L or DL-lysine, N-undecanoyl-L or DL-lysine, N-lauroyl-L or DL-lysine, N-myristoyl-
L or DL-lysine, N-palmitoyl-L or DL-lysine, N-
Stearoyl-L or DL-lysine, N-araquinoyl-L or D
L-lysine, N-behenoyl-L or DL-lysine, N-coconut fatty acyl-L or DL-lysine, N-isopalmitoyl-L or DL-lysine, N-isostearoyl-L or DL-lysine, N -
Oleoyl-L or DL-lysine, N-caproylhydroxy-
L or DL-lysine, N-capryloylhydroxy-L or DL-
Lysine, N-caprinoylhydroxy-L or DL-lysine, N
-Undecanoylhydroxy-L or DL-lysine, N-lauroylhydroxy-L or DL-lysine, N-myristoylhydroxy-L or DL-lysine, N-palmitoylhydroxy-L
Or DL-lysine, N-stearoylhydroxy-L or DL-lysine, N-araquinoylhydroxy-L or DL-lysine, N-
Behenoylhydroxy-L or DL-lysine, N-coconut fatty acid acylhydroxy-L or DL-lysine, N-isopalmitoylhydroxy-L or DL-lysine, N-isostearoylhydroxy-L or DL-lysine, N -Oleoylhydroxy-
L or DL-lysine, N-caproyl-L or DL-histidine, N
-Capryloyl-L or DL-histidine, N-Caprinoyl-L
Or DL-histidine, N-undecanoyl-L or DL-histidine, N-lauroyl-L or DL-histidine, N-myristoyl-L or DL-histidine, N-palmitoyl-L or DL-histidine, N-stearoyl-L Or DL-histidine, N-araquinoyl-L or DL-histidine, N-behenoyl-L or D
L-histidine, N-coconut fatty acid acyl-L or DL-histidine, N-isopalmitoyl-L or DL-histidine, N-isostearoyl-L or DL-histidine, N-oleoyl-L
And methyl ester such as DL-histidine, ethyl ester, propyl ester, isopropyl ester, butyl ester, pentyl ester, hexyl ester, phenyl ester, benzyl ester and amide, and the acid addition salts thereof include hydrochloride, acetic acid Salt, lactate, DL-pyrrolidonecarboxylate and the like. Commercially available raw materials can also be used for the purpose of the present invention.

[0018] (B) a group of the antimicrobial plant extracts, ginkgo (Ginkgo) genus Sasa (Sasa) genus, Job's tears (Coix)
Genus, genus Asiaarum , Hypericum ( Hyper
icum ), Birch ( Betula ), Rabbit ( Arnic )
a ) genus, chamomile ( Matricaria ), mugwort ( Artemisi
a) species, burdock (Arctium) genus, calendula (Calendul
a) species, knapweed (Centaurea) genus, Roman chamomile (Anthemis) genus Coptis (Coptis) genus, laurel (Laurus) genus, mulberry (Morus) genus, Humulus lupulus (Humul
us ) genus, wild mint ( Isodon ) genus, skullcap ( Scut )
ellaria) genus Salvia (Salvia) genus, shiso (Perilla)
Genus, Ibuki thyme (Thymus) species, mint (Menth
a ) Genus, genus Melissa, genus Rosmarinus, genus Lavandula, genus Tilia, genus Lonicera, genus Foeniculum, genus Cnidium , Theasinensis L.), Houttuynia
Genus, horse chestnut (Aesculus) genus, cherry (Prunus) genus, rose (Rosa) genus, Burnet (Sanguisorba) genus, pigweed (A
genus maranthus, genus Geranium, genus Syzygium, genus Paeonia , licorice ( Gly
cyrrhiza) genus Sophora (Sophora) genus, witch hazel (Ham
amelis) species, yellowfin tuna (Phellodendron) genus, San Show (Zanthoxylum) genus, purple (Lithospermum) genus, comfrey (Symphytum) genus, forsythia (Forsythia)
It is composed of extracts of plants belonging to the genera, Aloe , and Polygonatum .

Ginkgo ( Ginkgo biloba L.) is preferably used as a plant belonging to the genus Ginkgo . Although each site can be used, it is particularly preferable to use leaves or seeds.

[0020] Examples of the Sasa (Sasa) plant belonging to the genus, Sasa (Sasa kurilensis Makinoet Shibata), Oobazasa (Sasa megalophylla Makino et Uchida), dwarf bamboo (Sasa nipponica Makino et Shibata), Chimakizasa (Sasa palmata Nakai), Sasa (Sasa senan
ensis Rehd.), Sasa albo-marginata Makin
o et Shibata, Sasa veitchii Rehd.) and the like. Although each of these parts can be used, a leaf is particularly preferably used.

Examples of plants belonging to the genus Coix ( Coix ) include Coix lachryma-jobi L. and Coix lachr, which is the base plant of the crude drug "Yokuinin".
yma-jobi L. var. ma- yuen Stapf) is preferably used. Although each of these parts can be used, it is particularly preferable to use fruits or seeds.

[0022] Examples of the Kan'aoi (Asiasarum) plant belonging to the genus, is a MotoHara plant of herbal "Latest" thin blade Herba Asari (Asiasarum sieboldii F. Maekawa), Guilin Herba Asari (Asiasarum heterotropoides F.Maekawa var.
mandshuricum F. Maekawa), Kurofunesaishin ( Asias )
arum dimidiatum F. Maekawa), Oquezocysin ( As
iasarum heterotropoides F. Maekawa), Usgesaishin ( Asiasarum heterotropoides var. seoulense F. Ma)
ekawa) can be preferably used. Although each of these parts can be used, it is preferable to use a root or a rhizome.

The plants belonging to the genus Hypericum include Hypericum erectum Thun
b.), John's wort ( Hypericum perforatum
L.) and tomato ( Hypericum ascyron L.). Although each of these parts can be used, it is preferable to use whole plants.

Plants belonging to the genus Betula include Betula birch ( Betula ermanii Cham.) And Mizume ( Be
tula grossa Sieb.et Zucc.), black birch ( Betul
a lenta L.), Red birch ( Betula maximowicziana )
Regel), red birch ( Betula nigra L.), canoe birch ( Betula papyrifera Marsh.), White birch ( Betula pendula Roth), birch ( Betula platyp )
hylla Sukatchev var. japonica Hara), European birch ( Betula pubescens Ehrh.), onoole kamba ( Betula schmidtii Regel), Himalayan birch ( Betu
la utilis D. Don). Although each of these parts can be used, it is preferable to use leaves or bark.

The plants belonging to the genus Arnica include Arnica ( Arnica montana L.) and Rabbit ( A
rnica unalaschensis Less.). Although each of these parts can be used, it is preferable to use flowers, roots or whole plants.

[0026] Examples of the chamomile (Matricaria) plant belonging to the genus, other chamomile (Matricaria chamomilla L.) is a MotoHara plant of herbal "chamomile", Inukamitsure (Ma
tricaria inodora L.), koshidana ( Matricaria matr )
icaroides Porter), Deer ( Matricaria tetragono )
sperma Hara et Kitam.). Although each of these parts can be used, it is preferable to use a flower.

[0027] Examples of the plant belonging to the wormwood (Artemisia) species, mugwort (Artemisia princeps Pamp.), Ooyomogi (Artemisia montana Pamp.), Moukoyomogi (Artem
isiamongolia Fischer), Carrot ( Artemisia )
apiacea Hance), Ginseng ( Artemisia annua)
L.), is a MotoHara plant of herbal "Intin-koo" Artemisia capillaris (Artemisia capillaris Thunb.), Hamayomogi (A
rtemisia scoparia Waldstein) and the like can be preferably used. Although each of these parts can be used, it is preferable to use leaves or whole plants.

Examples of plants belonging to the genus Burdock ( Arctium ) include Burdock ( Arctium lappa L.) and Common Bu.
rdock ( Arctium minus Bernh.). Although each of these parts can be used, it is preferable to use roots or fruits.

[0029] Examples of the Calendula (Calendula) plant belonging to the genus, tow Calendula (Calendula officinalis
L.) and calendula ( Calendula arvensis L.). Although each of these parts can be used, it is preferable to use a flower.

Examples of plants belonging to the genus cornflower ( Centaurea ) include cornflower ( Centaurea cyanus L.),
Centaurea moschata L., Thrips palmum ( Centaurea americana Nutt.), Yellow sultan ( Centaurea suaveolens L.), cornflowers ( Centaurea macrosephala Puschk.), Cornflowers ( Centaurea montana L.), and the like. Although each of these parts can be used, it is particularly preferable to use flowers or whole plants.

Examples of plants belonging to the genus Roman chamomile ( Anthemis ) include the horned chamomile ( Anthemis arvensis).
L.), Roman chamomile ( Anthemis nobilis L.), Koya chamomile ( Anthemis tinctoria L.) and the like. Although each of these parts can be used, it is particularly preferable to use flowers or whole plants.

Plants belonging to the genus Coptis include, for example, spinach ( Coptis ), which is a base plant of the herbal medicine "ouren".
is japonica Makino), Kikubaouren ( Coptis japon )
ica var. japonica Satake), Ceribauren ( Coptis )
japonica var. dissecta Nakai), Koseriba spinach ( Coptis japonica var. major Satake), honeybee spinach ( Coptis trifolia Salisb.), baika spinach ( C
optis quinquefolia Miq.). Although each of these parts can be used, it is preferable to use a rhizome.

Examples of plants belonging to the genus Laurus include Laurus nobilis L .. Although each site can be used, it is preferable to use leaves.

Plants belonging to the mulberry genus ( Morus ) include:
Morus bomb ( Morus bomb)
ycis Koidz.), Magwa ( Morus alba L.), Rosou ( Mo
rusmulticaulis Perr.), Ogasawaraguwa ( Morus boni)
nensis Koidz.). Although each of these parts can be used, it is preferable to use root bark, leaves or fruits.

[0035] Examples of the Humulus lupulus (Humulus) plant belonging to the genus, is a MotoHara plant of herbal "hop" hop (Hu
mulus lupulus L.), Humulus lupulus
L. var. Cordifolius Maxim.), Humulus
scandens Merrill). Although each of these parts can be used, it is preferable to use female ears or whole plants.

[0036] As Yamahakka (Isodon) plant belonging to the genus is MotoHara plant crude drugs "Enmeisou" cause (Isodon japonicus Hara) and Kurobanahikiokoshi (Isodon trichocarpus Kudo) can be mentioned as preferred. Although each of these parts can be used, it is preferable to use the above-ground part.

Plants belonging to the genus Scutellaria include Scutellaria indica
L.), and Scutellaria baicalensis Georg., Which is a base plant of the crude drug "Ougon", are preferred. Although each of these parts can be used, it is preferable to use roots or whole plants.

[0038] Examples of the Salvia (Salvia) plant belonging to the genus, safflower Salvia (Salvia coccinea L.), sage (Salvia officinalis L.), Mizokouju (Salvia pl
ebeia R.Br.), Onisalvia ( Salvia sclarea L.) and the like. Although each of these parts can be used, it is preferable to use leaves or whole plants.

As a plant belonging to the genus Perilla , perilla ( Perilla fr), which is a base plant of the crude drug “Soyo”, is used.
utescens Britton var. acuta Kudo.), Chirimenjiso ( Perilla frutescens var. crispa f. crispa Decn)
e.), Aodiso ( Perilla frutescens var. crispa f.
viridis Makino), Catamejizo ( Perilla frutescens v
ar. crispa f. discolor Makino) and the like. Although each of these parts can be used, it is preferable to use leaves or branches.

[0040] Examples of the Ibuki thyme (Thymus) plant belonging to the genus, Ibuki thyme (Thymus serphyllu
m L. subsp. quinquecostatus Kitamura), Thymus serphyllum L. subsp. serp
hyllum ), Thymus vulgari (thyme, Thymus vulgari
s L.). Although each of these parts can be used, it is preferable to use leaves or whole plants.

The plants belonging to the genus Mentha include Mentha piperita L., which is the base plant of the crude drug "Mentha" and a variant thereof, Mentha.
arvensis L. var. piperascens Malin.) , and the like spearmint (Mentha viridis L.). Although each of these parts can be used, it is preferable to use the above-ground part.

Plants belonging to the genus Melissa include Melissa ( Melissaofficinalis L.).
And each site can be used, but it is preferable to use leaves.

[0043] Examples of the rosemary (Rosmarinus) plant belonging to the genus, rosemary (rosemary, Rosmarinus
officinalis L.), and each site can be used, but leaves are preferably used.

Plants belonging to the genus Lavandula include lavender ( Lavandula vera DC.) And hiroharabender ( Lavandula latifolia Med.). Although each of these parts can be used, it is preferable to use a branch of a flower or a band flower.

Examples of plants belonging to the genus Tilia include Tilia americana L., Tilia cordata Mill., Tilia europaea L., and Tilia japonica Si.
monk.), Hera ( Tilia kiusiana Makino et Shira)
s.), P. persica ( Tilia maximowicziana Shira)
s.), Bodaiju ( Tilia miqueliana Maxim.), Natsubodaiju ( Tilia platyphyllos Scop.) and the like. Although each of these parts can be used, it is preferable to use flowers, fruits or bark.

Examples of plants belonging to the genus Lonicera include honeysuckle (Lindera, Lonicera japonica Th).
unb.) and Lonicera gracilipes Miq.
var. glabra Miq.). Although each of these parts can be used, it is preferable to use flowers, stems or leaves.

Examples of plants belonging to the genus Fieniculum include the fennel ( Feniculum vulgare Mill.), Which is a base plant of the herbal medicine “Fenilla”, and the Italian fennel ( Foeniculum vulgare Mill. Var. Dulce Thell.).
Is mentioned. Although each of these parts can be used, it is preferable to use fruits.

[0048] Examples of the Hamazeri (Cnidium) plant belonging to the genus, Hamazeri (Cnidium japonicum Miq.), Jashou (Cnidium monnieri Cusson), herbal medicine "Sinensis"
( Cnidium officinale Mak)
ino) and the like. Although each of these parts can be used, it is preferable to use a rhizome.

[0049] tea as plants belonging to (Thea sinensis L.) class, tea (Thea sinensis L.), Toucha (Thea
sinensis L. var. macrophylla Sieb.) , Assam tea (Thea sinensis L. var. assamica Pierre ), oolong tea (Thea sinensis L. var. viridis Szkzyl .),
Safflower ( Thea sinensis L. var. Rosea Makino)
And the like. Although each of these parts can be used, it is preferable to use leaves.

Examples of plants belonging to the genus Houttuynia include Houttuynia cordata Thunb., Which is the base plant of the crude drug “Juyaku”. preferable.

Plants belonging to the genus Aesculus include Aesculus carnea Hayne, Aesculus chinensis Bunge, Aesculus chinensis (malonie, Aesculus hippocastanum L.), Aesculus turbinata and the like.
Each of these sites can be used, but fruits, seeds,
It is preferable to use bark.

Sakura (Prunus) As a plant belonging to the genus
Is the apricot (Prunus armeniaca L.), Atlantic pear
La (Prunus avium L.), plum (Prunus mume Sieb. Et
Zucc.), Peach (Prunus persica Batsch.), Nomomo (P
runus persica Batsch.var. davidiana Maxim.), Sumo
Mo (Prunus salicina Lindl.) Can be used preferably.
You. Each of these parts can be used, but the fruit or
Preferably, seeds are used.

Plants belonging to the genus Rosa include Rosa hybrida Hort., Rosa aci
cularis Lindl.), Takanebara ( Rosa acicularis Lind)
l. var. nipponensis Koehne), Mokkobara ( Rosa b )
anksiae Aiton), canina rose ( Rosa canina L.), centifolia rose ( Rosa centifolia L.), moss rose ( Rosa centifolia L. var. muscosa Seringe), kosinbara ( Rosa chinensis Jacq.), damask rose ( Ro )
sa damascena Miller, Gallicahala ( Rosa gallica )
L.), Rosa hirtula Nakai, Rosa moschata Herr., Rosa foetida Herr., Gigantea rose ( Rosa gigan)
tea Collett et Hemsl.), Odratava ( Rosa odor)
ata Sweet), Yamaibara ( Rosa sambucina Koidz.),
Hermanus ( Rosa rugosa Thunb.), Neubara ( Rosa multiflora Thunb.)
Terihanoibara ( Rosa wichuraiana Crepin var. Ampul)
licarpa Honda), Fujiibara ( Rosa fujisanensis Mak)
ino) and the like. Although each of these parts can be used, it is preferable to use fruits.

As a plant belonging to the genus Warmokou ( Sanguisorba ), for example, a plant belonging to the genus Shirobanawaremo ( Sanguisorba albifl)
ora Makino), callite ( Sanguisorba hakusanens )
is Makino), Dutch Guinea fowl ( Sanguisorba minor)
Scop.), Emperor's wort ( Sanguisorba obtusa Max)
im.), is a MotoHara plant of herbal "healing" Burnet (San
guisorba officinalis L.), Takamine tow goldenrod (Sangu
isorba stipulata Rafin.), Kobanawaremoko ( Sangu)
isorba tenuifolia Fisch.). Although each of these parts can be used, it is preferable to use a rhizome.

[0055] Examples of the pigweed (Amaranthus) plant belonging to the genus, Sen'ninkoku (Amaranthus caudatus L.), Sugimorigeitou (Amaranthus cruentus L.), Amaranthus lividus (Am
aran thus lividus L. var. ascendens Thell.), Amaranthus patulus Bertoloni, Aoanthus ( Amaranthus retroflexus L.), Haribiyu ( A
maranthus spinosus L.), Ayu ( Amaranthus tricolor )
L. subsp. Mangostanus Aellen), Amaranthus tricolor (Amara
nthus tricolor L. subsp. tricolor), and the like Amaranthus viridis (Amaranthus viridis L.). leaf,
Flowers, fruits and whole plants can be used.

Examples of plants belonging to the genus Geranium include Geranium thunbergii Sieb. Et Zucc., Which is the base plant of the crude drug "Genonium".
Lobatum Naka ( Geranium carodinianum L.), Ibuki Fuuro ( Geranium dahuricum DC. Var. Lobulatum Naka)
i), Gunknifeuro ( Geranium onoei Franch. et Sav
at.), Iyofuro ( Geranium shikokianum Matsumur)
a), Hakusanfuuro ( Geranium yesoense Franch. et
Savat. Var. Nipponicum Nakai), Tachihiro ( Gerani )
um japonicum Franch. et Savat.), Ichigefuuro ( Ge
ranium sibiricum L.), Kikuba fuluro ( Erodium stepha )
nianum Willd.). Although each of these parts can be used, it is preferable to use the above-ground part.

[0057] As the rose apple (Syzygium) plant belonging to the genus, Mizurenbu (Syzygium aqueum Alston), a MotoHara plant of herbal "clove" clove (Syzygium aro
maticum Merrill et Perry, Eugenia caryophyllata Th
unb.), Futomomo ( Syzygium jambos Alston), Murray peach ( Syzygium malaccensis Merrill et Perr
y), Rembu ( Syzygium samarangense Merrill et Perr
y) and the like. Although each of these parts can be used, it is preferable to use a bud or a flower.

Examples of plants belonging to the genus Paeonia include Paeonia japonica Miyabe et Takeda, a base plant of the herbal medicine " Paeonia ", Paeonia lactiflora Pall., And Paeonia obovata Maxim. ), Netherlands peony (Paeonia officinalis L.), e buckwheat peony (Paeo
nia tenuifolia L.), a button ( Paeonia su ffruticosa Andr., Paeonia mo .)
utan Sims.) and its relatives ( Paeonia delavayi Franc)
h., Paeonia lutea Franch., Paeonia potanini Kom.)
And the like. Although each of these sites can be used, it is preferable to use a root.

As a plant belonging to the genus Glycyrrhiza , licorice ( Glycyrrhiza glabra L. var. Glandulifera Regel et.
Herder), Glycyrrhiza echinata
L.), Spanish liquorice ( Glycyrrhiza glabra L.),
Glycyrrhiza uralensis Fisch. Et D
C.) and the like. Although each of these sites can be used, it is preferable to use a root.

[0060] as Sophora (Sophora) plant belonging to the genus is a MotoHara plant of herbal "downstairs" enju (Soph
ora japonica L.) and Clara ( Sophora flavescens Aiton), which is the base plant of the crude drug "Kudin".
Although each of these parts can be used, it is preferable to use buds or roots.

Examples of plants belonging to the genus Mansac ( Hamamelis ) include hamsac ( Hamamelis japonica Sieb. Et Zuc).
c.) and Hamamelis virginiana L .. Although each of these parts can be used, it is preferable to use leaves.

[0062] Examples of the yellowfin tuna (Phellodendron) plant belonging to the genus, is a MotoHara plant of herbal "bark" yellowfin tuna (Phellodendron amurense Rupr.), Oobanokihada (Phellodendron amurense var. Japonica Ohwi) , Miyamakihada (Phellodendron amurense var. Lavallei S
prag.), Hirohakihada ( Phellodendron amurense var.)
sachalinense Fr. Schmidt.), bark tree ( Phellodendro )
n chinense Schneid.). Although each of these parts can be used, it is preferable to use bark.

[0063] Examples of the pepper (Zanthoxylum) plant belonging to the genus, is a MotoHara plant of herbal "pepper" pepper (Zanthoxylum piperitum DC.), Asakura bungeanum (Zanthoxylum piperitum f. Inerme Makino) ,
Yamaasakurazanshaw ( Zanthoxylum piperitum f. B
revispinosum Makino). Although each of these parts can be used, it is preferable to use fruit or pericarp.

Plants belonging to the genus Lithospermum include Lithospermum erythrorhizon Siebold et Zuccarin, which is the base plant of crude drug “Sicon”.
i) and firefly kazura ( Lithospermum zollingeri DC.). Each of these sites can be used,
It is preferred to use roots or fruits.

Examples of plants belonging to the genus Symphytum include Symphytum officinale.
L.), and each site can be used, but it is preferable to use rhizomes and roots.

Examples of plants belonging to the genus Forsythia include Forsythia suspensa Vahl., Forsythia viridissima Lindl., And Forsythia koreana Nakai, which are the base plants of the crude drug "Forsythia". Can be Although each of these parts can be used, it is preferable to use fruits.

Plants belonging to the Aloe genus plant include Aloe ferox Mil, which is the base plant of crude drug “Aloe”.
l., Aloe africana Mill., Aloe speciosa Baker, Aloe
arborescens Mill., Aloe succotrina Lam., Aloe pli
catilis Mill., Aloe bainesii Th. Dyer., Aloe p
erryi Baker, and Aloe vera L., etc., Kidachiaroe (Aloea
rborescens Mill. var. natalensis Berg.). Although each of these parts can be used, it is preferable to use a leaf part.

[0068] Examples of the Solomon's seal (Polygonatum) plant belonging to the genus, is a MotoHara plant of herbal "monarchy" Narukoyuri (Polygonatum falcatum A. Gray), Oonarukoyuri (Polygonatum macranthum Koidzumi), key Small pink flowers Le Koyuri (Polygonatum sibricum Red. ), Carbanalco lily ( Polygonatum stenophyllum Maxim.) And the like. Although each of these parts can be used, it is preferable to use a rhizome.

One or more species are selected from the above plant group, and are subjected to extraction as it is or after being subjected to treatment such as shredding, drying, and pulverization. Examples of the extraction solvent include water, lower alcohols such as methanol, ethanol, propanol, isopropanol and butanol, ethylene glycol, diethylene glycol, propylene glycol, and the like.
Dipropylene glycol, 1,3-butylene glycol, 1,
Polyhydric alcohols such as 2-pentylene glycol, isoprene glycol, hexylene glycol, glycerin,
Organic solvents such as esters such as methyl acetate, ethyl acetate and isopropyl acetate, ethers such as ethyl ether and isopropyl ether, ketones such as acetone, and mixtures thereof can be used.

The extraction is performed by immersing the plant in the above-mentioned extraction solvent. In order to increase the extraction efficiency, the extraction solvent may be stirred or homogenized in the extraction solvent. The extraction temperature is suitably from 0 ° C. to the boiling point of the extraction solvent or lower, and the extraction time is suitably about 4 hours to 2 weeks, depending on the extraction temperature.

The above-mentioned plant extract can be added as it is to the cosmetics as it is, or it can be blended after adding purification operations such as deodorization, decolorization, concentration, and fractionation as long as the antibacterial action is not lost. Can also.

The amounts of the antifungal agent of the present invention, the antibacterial compound of the group (A) and the antibacterial plant extract of the group (B) with respect to the total amount of the antibacterial hypoallergenic cosmetic of the present invention are as follows. 0.1 to 10.0% by weight of acylcarnitine and / or a salt thereof, 0.01 to 0.2% by weight of paraoxybenzoate, 0.05 to 0.3% by weight of phenoxyethanol, Photosensitive element 10
0.00 for each of No. 1, 201 and 401
0.01-0.002% by weight, 0.0001-0.1% by weight for hinokitiol, 0.00% for N-long-chain acyl basic amino acid derivatives and / or acid addition salts thereof.
It is appropriate that the amount is about 1 to 0.5% by weight, and about 0.01 to 10.0% by weight of the antibacterial plant extract in the form of a crude extract.

The antifungal agent according to the present invention is particularly useful for a system containing a large amount of water and an oil-in-water emulsion system in which the external phase is an aqueous phase. Therefore, antibacterial hypoallergenic cosmetics according to the present invention,
Skin cosmetics such as lotions, emulsions, gels, creams, packs, make-up base lotions or creams,
Makeup cosmetics such as emulsion or creamy foundation, emulsified eye color or cheek color, aqueous suspension type eyeliner, emulsified eyeliner or mascara, body cosmetics such as body lotion, hand cream, leg cream, etc. Cosmetics such as cosmetics, shampoos, rinses and hair stylings, or cleaning agents such as cleansing agents, facial cleansers, liquid soaps and hand soaps.

Further, the antibacterial and hypoallergenic cosmetics according to the present invention include oily components, surfactants, lower alcohols, humectants, pigments, ultraviolet absorbers, antioxidants, as long as the characteristics of the present invention are not impaired. General cosmetic raw materials such as fragrances, and physiologically active ingredients such as skin cell activators, anti-inflammatory agents, and whitening agents such as vitamins and protein hydrolysates can also be contained.

[0075]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

Examples 1 to 8 Antifungal agent O-decanoyl-DL-carnitine hydrochloride, O-undecanoyl
-DL-carnitine hydrochloride, O-dodecanoyl-DL-carnitine hydrochloride, O-tridecanoyl-DL-carnitine acetate, O-tetradecanoyl-DL-carnitine acetate, O-pentadecanoyl-DL-carnitine acetate , O-hexadecanoyl-DL-carnitine hydrochloride, and O-heptadecanoyl-DL-carnitine acetate were each dissolved in sterile purified water to 0.01 M, and the pH was adjusted to 6.0. Example 8 was used.

[0077] The above Examples 1 to 8, and the antifungal activity black Aspergillus Comparative Example 1 to Comparative Example 7 shown in Table 1 (As
pergillus niger ). Comparative Example 1
-About Comparative Example 7, pH was adjusted to 6.0. Black Aspergillus 2.9 × 1 in each of Examples and Comparative Examples
0 ⁵ / g was inoculated was measured over time the number of viable bacteria was cultured at 25 ° C.. The results are shown in Table 2.

[0078]

[Table 1]

[0079]

[Table 2]

As is clear from Table 2, in each of Examples 1 to 8 of the present invention, the viable count after 14 days was 1/1000 or less of the inoculated count, indicating that there was sufficient antifungal activity. Activity was observed. On the other hand, Comparative Examples 1 and 2 in which the carbon chain length of the acyl group is shorter than those used in the antifungal agent according to the present invention, and Comparative Examples 3 and 4 in which the carbon chain length is longer, contain DL-carnitine salt. Comparative Example 5 and Comparative Example 6
As in Comparative Example 7, which was sterilized purified water whose pH was adjusted, no effective antifungal activity was observed.

Next, examples of the antibacterial and hypoallergenic cosmetics according to the present invention will be described. The plant extract used in the following examples was prepared by drying and crushing 500 g of each plant,
It was immersed in 1 liter of extraction solvent, allowed to stand at 25 ° C. for 1 week, and then filtered to collect a filtrate.

Example 9 Toner (1) Ethanol 5.00 (% by weight) (2) Polyoxyethylene (60E.O.) hydrogenated castor oil 1.00 (3) Fragrance 0.10 (4) Paraoxyl Methyl benzoate 0.05 (5) Dipropylene glycol 1.00 (6) 1,3-butylene glycol 3.00 (7) O-decanoyl-DL-carnitine hydrochloride 1.00 (8) Purified water 88.85 Production method: (2) to (4) are added to (1) and dissolved to form an alcohol phase. On the other hand, (5) to (7) are sequentially dissolved in (8) to form an aqueous phase. Add the alcohol phase to the aqueous phase, stir and mix.

Example 10 Emulsion (1) Cetanol 1.0 (% by weight) (2) Beeswax 0.5 (3) Vaseline 2.0 (4) Squalane 6.0 (5) Jojoba oil 2.0 ( 6) polyoxyethylene (20E.O.) sorbitan 1.0 monostearate (7) glyceryl monostearate 1.0 (8) 1,3-butylene glycol 5.0 (9) glycerin 5.0 ( 10) O-undecanoyl-DL-carnitine hydrochloride 0.5 (11) Purified water 72.8 (12) Ethanol 3.0 (13) 2-Phenoxyethanol 0.1 (14) Fragrance 0.1 Production method: (1) The oil phase components of (7) to (7) are mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (8) to (11) are mixed and dissolved to 75 ° C. The oil phase is added thereto, and the mixture is emulsified by a homomixer, cooled, and (12) to (14) are sequentially added and mixed at 40 ° C.

[Example 11] Oil-in-water cream (1) Beeswax 6.000 (wt%) (2) Cetanol 5.000 (3) Reduced lanolin 8.000 (4) Squalane 27.500 (5) Glyceryl fatty acid Ester 4.000 (6) Lipophilic glyceryl monostearate 2.000 (7) Polyoxyethylene (20E.O.) sorbitan 5.000 Monolaurate (8) d-δ-tocopherol 0.050 (9 ) 1,3-butylene glycol 5.000 (10) Photosensitizer 201 0.001 (11) O-dodecanoyl-DL-carnitine hydrochloride 1.000 (12) 1,3-butylene glycol of mannen wax leaf 0.200 Extract (13) Purified water 36.149 (14) Fragrance 0.100 Production method: The oil phase components of (1) to (8) are mixed and dissolved by heating to 75
° C. On the other hand, the aqueous phase components (9) to (13) are mixed and dissolved to 75 ° C. The oil phase is added to the mixture, and the mixture is emulsified with a homomixer and then cooled.

Example 12 Skin Gel (1) Dipropylene glycol 10.00 (% by weight) (2) Methyl parahydroxybenzoate 0.05 (3) 2-Phenoxyethanol 0.05 (4) Carboxyvinyl polymer 0 .30 (5) O-tridecanoyl-DL-carnitine acetate 0.50 (6) Purified water 84.10 (7) 1.0% by weight aqueous solution of potassium hydroxide 5.00 Manufacturing method: (4), (6) After dissolving (5), (2) and (3) are dissolved and added to (1), and then (7) is added to increase the viscosity.

Example 13 Essence (1) 1,3-butylene glycol 5.00 (wt%) (2) Carboxyvinyl polymer 0.40 (3) O-tetradecanoyl-DL-carnitine acetate 0 .20 (4) Methyl paraoxybenzoate 0.05 (5) 50% by volume ethanol 0.10 extract of whole Hypericum perforatum (6) 50% by volume ethanol extract of chamomile flower 0.10 (7) L-arginine 1 0.000 (8) Purified water 93.15 Production method: (1) to (7) are sequentially added to (8) and uniformly dissolved.

[Example 14] Water-in-oil cream (1) Liquid paraffin 30.000 (% by weight) (2) Microcrystalline wax 2.000 (3) Vaseline 5.000 (4) Diglyceryl dioleate 5.000 (5) Sodium L-glutamate 1.600 (6) L-serine 0.400 (7) 1,3-butylene glycol 3.000 (8) Photosensitizer 401 0.001 (9) O-penta Decanoyl-DL-carnitine hydrochloride 0.500 (10) Purified water 52.399 (11) Fragrance 0.100 Production method: (5), (6) is dissolved in a part of (10) to 50 ° C.
(4) is gradually added to a mixture heated to 50 ° C. while stirring. This was previously mixed and heated to 70 ° C. (1)
To (3) uniformly dispersed. To this, (7) to (9) are dissolved in the remainder of (10), and the mixture is heated to 70 ° C., added, emulsified by a homomixer, cooled, and added with (11) at 40 ° C. and mixed.

Example 15 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self-emulsification Glyceryl monostearic acid 2.0 ester (5) 1,3-butylene glycol 10.0 (6) O-hexadecanoyl-DL-carnitine hydrochloride 0.5 (7) N-coconut fatty acid acyl-L- Arginine ethyl 0.2 Ester DL-pyrrolidone carboxylate (8) Potassium hydroxide 0.3 (9) Purified water 67.9 (10) Titanium oxide 2.0 (11) Bengala 0.4 (12) Yellow iron oxide 0.1 (13) Fragrance 0.1 Production method: The oil phase components of (1) to (4) are mixed, and dissolved by heating.
° C. On the other hand, the aqueous phase components (5) to (9) are mixed and dissolved by heating, and the pigment components (10) to (12) are added thereto and uniformly dispersed to 75 ° C. Next, the oil phase component was added to the aqueous phase component, and the mixture was emulsified by a homomixer and then cooled.
Add and mix (13) with.

Example 16 Emulsion Foundation (1) Stearic acid 2.00 (% by weight) (2) Squalane 5.00 (3) Octyldodecyl myristate 5.00 (4) Cetanol 1.00 (5) Decaglyceryl monoisopalmitate 9.00 (6) 1,3-butylene glycol 6.00 (7) O-heptadecanoyl-DL-carnitine hydrochloride 1.00 (8) N-lauroyl-DL-lysine ethyl ester hydrochloride Salt 0.10 (9) Potassium hydroxide 0.08 (10) Purified water 52.37 (11) Titanium oxide 9.00 (12) Talc 7.40 (13) Bengala 0.50 (14) Yellow iron oxide 1 10 (15) Black iron oxide 0.10 (16) 1.2-pentylene glycol 0.20 extract of birch bark (17) Fragrance 0.15 Production method: Mix oil phase components (1) to (5) , Heat melting Te 75
° C. On the other hand, the aqueous phase components (6) to (10) are mixed and dissolved by heating, and the pigment components (11) to (15) are added thereto and uniformly dispersed to 75 ° C. Next, the oil phase component was added to the aqueous phase component, emulsified by a homomixer, and then cooled.
Add (16) and (17) at ℃ and mix.

Example 17 Emulsion Eyeliner (1) Stearic acid 3.50 (% by weight) (2) Beeswax 2.00 (3) Carnauba wax 0.50 (4) Microcrystalline wax 5.00 (5) 1,3-butylene glycol 7.00 (6) O-tridecanoyl-L-carnitine acetate 1.00 (7) triethanolamine 1.50 (8) Methyl parahydroxybenzoate 0.05 (9) Purified water 49. 35 (10) 3.0% by weight bentonite liquid 20.00 (11) Titanium oxide 8.00 (12) Carbon black 2.00 (13) Fragrance 0.10 Production method: oil phase components of (1) to (4) Are mixed, heated and dissolved.
The aqueous phase components (5) to (9) are mixed, heated, and added with stirring to emulsify. Next, (10) to (12) were added to the emulsion, and the mixture was dispersed through a colloid mill, cooled, and cooled to 40 ° C.
Add (13) and mix.

Example 18 Hand cream (1) Cetanol 4.0 (% by weight) (2) Vaseline 2.0 (3) Liquid paraffin 10.0 (4) Glyceryl monostearate 1.5 (5) Polyoxyethylene (60E.O.) glyceryl 2.5 isostearate (6) β-carotene 0.2 (7) glycerin 15.0 (8) O-undecanoyl-L-carnitine hydrochloride 0.5 (9) O-hexadecanoyl-L-carnitine hydrochloride 0.5 (10) 1,3-butylene glycol extract of hamamelis leaves 0.5 (11) 1,2-pentylene 1.0 glycol extract of whole meadow grass (12) Purified water 62.3 Production method: The oil phase components (1) to (6) are mixed and dissolved by heating to 75
° C. On the other hand, the aqueous phase components (7) to (12) are mixed and dissolved to 75 ° C. The oil phase is added thereto, and the mixture is emulsified by a homomixer and then cooled.

Example 19 Cleansing Gel (1) Glycerin 15.0000 (% by weight) (2) 1,3-butylene glycol 8.0000 (3) Polyoxyethylene (50E.O.) hydrogenated castor oil 0000 (4) 2-phenoxyethanol 0.0500 (5) Photosensitizer 101 0.0005 (6) Silicic anhydride 7.0000 (7) Carboxyvinyl polymer 0.5000 (8) O-dodecanoyl-L-carnitine acetate 2.5000 (9) Purified water 57.3495 (10) Fragrance 0.1000 (11) 10.0% by weight aqueous solution of potassium hydroxide 4.5.000 Production method: After mixing (6) to (9) to make uniform , (1) and (2)
(3) to (5) are dissolved and added, and the mixture is heated to 70 ° C. to be uniform. Then, the mixture is cooled, (10) and (11) are added and mixed at 40 ° C.

Example 20 Hair Shampoo (1) Sodium alkyl ether sulfate 18.00 (% by weight) (2) Coconut fatty acid diethanolamide 2.00 (3) O-decanoyl-L-carnitine hydrochloride 1.50 (4) Hinokitiol 0.02 (5) Fragrance 0.20 (6) Methyl paraoxybenzoate 0.20 (7) Ethanol 2.00 (8) Purified water 76.08 Production method: (1) to (7) in order Add to (8) and mix uniformly.

Example 21 Hair rinse (1) Hexadecanol 2.00 (% by weight) (2) Octadecanol 2.00 (3) Jojoba oil 0.50 (4) Glyceryl monostearate (5) Cetyl 2-ethylhexanoate 1.50 (6) O-heptadecanoyl-DL-carnitine hydrochloride 1.50 (7) 1,3-butylene glycol 5.00 (8) Methyl paraoxybenzoate 0.10 (9) Purified water 83.29 (10) Glycerin 3.00 (11) Hinokitiol 0.01 (12) Fragrance 0.10 Production method: The oil phase components (1) to (5) are mixed, heated and dissolved, and ° C
And On the other hand, the aqueous phase components (6) to (9)
The mixture is heated to 0 ° C., and the oil phase component is added thereto and emulsified by a homomixer. After cooling, add (10) to (12) at 40 ° C and mix.

With respect to Examples 9 to 21 of the present invention, antibacterial activity and discomfort during use were evaluated. At that time, in each of the examples, the acylcarnitine salt, which is the antifungal agent according to the present invention, was replaced with purified water. Comparative Examples 8 to 20 and Example 10 were repeated without adding the acylcarnitine salt. Comparative Example 21 in which the blending amount of phenoxyethanol was doubled was used in Comparative Example 21 and Comparative Example in which the blending amount of 2-phenoxyethanol and methyl paraoxybenzoate was increased three times without blending the acylcarnitine salt in Example 12. 22, the same evaluation as in Comparative Example 23 was carried out except that no acylcarnitine salt was added, the amount of methyl parahydroxybenzoate was doubled, and 0.01% by weight of butyl paraoxybenzoate was added, as Comparative Example 23. Was. Comparative Examples 21 to 23
Was adjusted to 100% by weight with purified water.

The antibacterial activity was measured using Escherichia coli ( Escher) as a test bacterium.
ichia coli ), Staphylococcus aureu
s ), bacteria of Pseudomonas aeruginosa and Propionibacterium acnes , and Candida ( C)
andida albians ), Aspergillus nige
r ) and dandruff fungus ( Pityrosporum ovale ) using 10 ⁶ bacteria and 10 ⁵ fungi per gram of sample.
Individuals were inoculated and cultured at 37 ° C. and 25 ° C., respectively.
The viable cell count after one week was measured and evaluated. If no viable bacteria were observed after 2 weeks for bacteria and if the number of viable bacteria for fungi was 1/1000 or less and 100 or less after 2 weeks, it was determined that the antibacterial activity was sufficient. In the case of No. 3, the case where sufficient antibacterial activity was observed was indicated by ○, and the case where it was not observed was indicated by ×.

The discomfort during use was such that 20 female panelists in their 20s to 50s were grouped into one group, and each group was blindly used in each of the examples and comparative examples. They were asked to evaluate whether they felt discomfort such as pain, tingling, and tingling. The evaluation result is
Scored as "not felt; 0 points", "slightly felt; 1 point", "slightly felt; 2 points", "clearly felt; 3 points", "strongly felt; 4 points" The values were calculated and are shown in Table 4.

[0098]

[Table 3]

As is clear from Table 3, all of the examples of the present invention exhibited sufficient antibacterial activity against all test bacteria. On the other hand, in Comparative Examples containing no acylcarnitine salt, except for Comparative Examples 21 to 23 in which the amount of ethanol, 2-phenoxyethanol, and paraoxybenzoate was increased, the antibacterial activity was insufficient, especially against fungi. A remarkable decrease in antibacterial activity was observed.

[0100]

[Table 4]

As is evident from Table 4, in the group using the examples of the present invention, discomfort during use is hardly felt or slightly felt, and does not cause a problem in actual use. Was. In contrast,
In Comparative Example 8 using group containing no acylcarnitine salt,
The discomfort at the time of use was slightly stronger than that of the Example 9 use group, and the discomfort was clearly recognized also in each of the use groups of Comparative Examples 21 to 23 showing sufficient antibacterial activity. Was.

In Examples 1 to 8 of the present invention, no decrease in antifungal activity was observed even after storage at 25 ° C. for 6 months, and in Examples 9 to 21 of the present invention, 25 When stored at 6 ° C. for 6 months, no change in the condition was observed, and no problematic skin irritating reaction was observed in a 48-hour back skin obstruction sticking test by 30 male panelists.

[0103]

As described in detail above, according to the present invention, pH
A highly safe antifungal agent without being affected by or other compounding ingredients, exhibit sufficient antibacterial activity, show high safety, and have only low irritation to the skin Thus, an antibacterial and hypoallergenic cosmetic which did not cause discomfort even during use could be obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A01N 65/00 A01N 65/00 A A61K 7/00 A61K 7/00 CK MNR 7/02 7 / 02 Z 7/032 7/032 7/035 7/035 7/075 7/075 7/08 7/08 7/48 7/48 (72) Inventor Masumi Takei 112-Nogami, Okada-cho, Yoka City, Shiga Prefecture F-term in Noevir Shiga Central Research Laboratories (reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB132 AB172 AB232 AB242 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC172 AC242 AC432 AC442 AC482 AC582 AC642 AC691 AC711 AC782 AC852 AD552 AD622 CC01 CC04 CC05 CC11 CC12 CC14 CC38 CC39 DD32 DD41 EE03 EE10 4H011 AA02 AA03 BA01 BA06 BB03 BB06 BB22 BC01 BC03 BC06 BC18 BC19 DA13 DA16 DA17 DH02 DH03 DH08 DH13

Claims (2)

[Claims] 1. An antifungal agent comprising one or more selected from the acylcarnitines represented by the formula (1) and salts thereof. Embedded image (In the formula, R ¹ represents an alkyl group or an alkenyl group having a straight or branched chain having 9 to 16 carbon atoms). 2. One or two of the antifungal agents according to claim 1.
And at least one species selected from the group consisting of (A) paraoxybenzoate, phenoxyethanol, photosensitizer 101, photosensitizer 201, photosensitizer 401, hinokitiol, N-long-chain acyl basic amino acid derivatives, and acid addition salts thereof. And / or (B) Ginkgo ( Ginkg
o) the genus Sasa (Sasa) genus, Job's tears (Coix) genus, Kan'aoi (Asiasarum) genus, St. John's wort (Hypericum)
Genus, Birch ( Betula ), Rabbit ( Arnica ),
Chamomile ( Matricaria ) genus, Artemisia genus,
Burdock (Arctium) genus, Calendula (Calendula) genus, knapweed (Centaurea) genus, Roman chamomile (Anthemi
s) genus Coptis (Coptis) genus, laurel (Lauru
s ) genus, Morus genus, Humulus
Genus, genus Isodon , Scutellaria ( Scutella )
ria ), genus Salvia, genus Perilla ,
Thymus , Mentha
Genus, genus Melissa, genus Rosmarinus , lavender ( Lavandula ), genus Tilia, genus Lonicera, genus Foeniculum, genus Cnidium , Thea sinensis L .), Houttuynia genus,
Aesculus genus, Prunus genus, Rosa genus, Sanguisorba genus, Ayu ( Ama )
ranthus) genus, Fuurosou (Geranium) genus, rose apple (S
yzygium ), button ( Paeonia ), licorice ( Glycyr )
rhiza ), genus ( Sophora ), witch hazel ( Hamame )
lis ), Yellowfin ( Phellodendron ), Salmon ( Za)
nthoxylum) genus, purple (Lithospermum) genus, comfrey (Symphytum) genus, forsythia (Forsythia) genus,
An antibacterial and hypoallergenic cosmetic comprising an extract of one or more plants selected from the group consisting of plants belonging to the genus Aloe and the genus Polygonatum .