JP2022138175A - External composition for skin - Google Patents

Abstract

To provide an external composition for skin that improves resilience and firmness of the skin, wherein the composition has an improved use feeling with reduced stickiness felt when a large amount of nicotinamide is blended, deposition of the composition is reduced during its use or storage, and the composition has improved emulsion stability at high temperatures.SOLUTION: An external preparation for skin contains following components (A)-(D): (A) nicotinamide 1-10 mass%, (B) halotolerant water-soluble polymer 0.05-2 mass%, (C) a phosphate surfactant and (D) a polyhydric alcohol 5-25 mass%.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a composition for external use on the skin, which improves the firmness and elasticity of the skin, has an excellent non-sticky feeling in use, is excellent in the effect of suppressing crystal precipitation, and has good emulsification stability at high temperatures.

In recent years, as a product concept for cosmetics, many products aimed at improving blemishes, wrinkles, sagging, pigmentation, etc. due to aging, stress, ultraviolet rays, air dryness, etc. have been released. In particular, morphological changes such as wrinkles and sagging give the impression that aging has progressed, so many people desire improvement. The addition of nicotinic acid amide as an effective ingredient has the effect of improving rough skin and improving keratin, and is highly safe even when a large amount is added, and can improve the firmness and elasticity of the skin (Patent Document 1).

However, it is known that when a large amount of nicotinic acid amide is blended, stickiness, creases, and the like occur, resulting in a poor feel during use (Patent Document 2). In particular, in the case of an external skin composition containing 1% by mass or more of nicotinic acid amide, crystals of nicotinic acid amide precipitate when the content dries after adhering to the mouth or cap, or when adhering to the side of the container. It is known to do (patent document 3, patent document 4).

On the other hand, in Patent Document 2, by using a specific branched-chain hydrocarbon and a specific highly spreadable oil together, the stickiness when a large amount of nicotinic acid amide is blended was suppressed, but the contents are mouth-watering. In some cases, crystals adhered to the parts and caps and precipitated, hindering smooth opening and closing of the container. In addition, in the oil-in-water emulsion composition, by using an ester of a linear fatty acid and polyethylene glycol as an emulsifier and adding vaseline, 1% or more of nicotinic acid amide can be added. It has been reported to obtain an oil-in-water emulsified composition that is free from irritation and stickiness, has an excellent feeling in use, and has an excellent effect of inhibiting crystallization (Patent Document 5). However, in Patent Document 5, although a comprehensively good composition for external use on the skin is obtained, it is limited to an oil-in-water emulsion containing petrolatum as an essential component, and it is difficult to say that it has sufficient versatility. In Patent Document 3, crystal precipitation is improved by blending a specific cation-containing polymer, but the stickiness increases and the feeling of use is not good.

On the other hand, as a water-soluble polymer that is blended as a thickener for external skin preparations, acrylic acid-based thickeners such as carbomer can be mentioned, but they generally have poor salt tolerance, and depending on the type of electrolyte, they can significantly reduce viscosity or aggregate. It is well known that it causes poor stability due to the occurrence of For example, Patent Document 6 discloses a technique of using specific surfactants (polyoxyethylene-added castor oil and polyoxyethylene-added sorbitol fatty acid ester) in order to obtain stability at high temperatures. . Furthermore, since the room temperature in the summertime is rising due to climate warming, there is a need for formulations with higher resistance to high temperatures than ever before. Specifically, up until now, it was thought that stability at 50°C or higher was sufficient, but recently there are cases where it is necessary to confirm storage stability up to about 60°C. In general, increasing the storage temperature causes the viscosity to decrease and the stability to decrease significantly. In other words, storage at a higher temperature imposes a higher load on storage stability than storage at a lower temperature.

Based on the above, by blending nicotinic acid amide with a phosphoric acid ester surfactant and its derivatives, it is possible to improve the firmness and elasticity of the skin. In addition, there is no known composition for external use on the skin that has good emulsification stability even at high temperatures.

JP-A-10-130135 Japanese Patent Publication No. 2003-502435 Japanese Patent Publication No. 2002-537241 JP 2018-168105 A JP 2018-172304 A JP 2018-168146 A

An object of the present invention is to improve the feel of use such as stickiness that occurs when a large amount of nicotinic acid amide is incorporated, to improve the precipitation that occurs during use and storage, and to improve the emulsification stability at sufficiently high temperatures.

In view of this situation, the inventors of the present invention, as a result of extensive research to solve the above problems,
the following components (A)-(D);
(A) Nicotinamide 1 to 10% by mass
(B) salt-tolerant water-soluble polymer 0.05 to 2% by mass
(C) phosphate ester surfactant (D) polyhydric alcohol 5 to 25 mass%
The inventors have found that an external preparation for skin containing can solve the above problems, and have completed the present invention.

In the present invention, the blending mass ratio of component (D) and component (A) is
It relates to an external composition for skin where (D)/(A)≧2.

The present invention further provides a composition for external use on the skin, wherein the salt-tolerant water-soluble polymer of component (B) is one or more selected from cellulose derivatives, hydrophobically modified polyether urethanes and copolymers containing acryloyldimethyltaurate salt as monomers. It is about things.

The present invention further provides that the salt-tolerant water-soluble polymer of component (B) is hydroxypropyl methylcellulose stearoxy ether, (Na acrylate/Na acryloyldimethyl taurate) copolymer, (hydroxyethyl acrylate/Na acryloyl dimethyl taurate) copolymer, (acryloyl) The present invention relates to an external composition for skin, which is one or more selected from ammonium dimethyltaurate/vinylpyrrolidone) copolymer and (PEG-240/decyltetradeceth-20/HDI) copolymer.

The present invention further relates to a sheet-like external preparation for skin impregnated with the composition for external use described above.

The composition for external use on the skin of the present invention improves the firmness and elasticity of the skin, is non-sticky and has an excellent feeling in use, and has effects of suppressing crystal precipitation and excellent emulsification stability at high temperatures.

The present invention will be described in detail below. In this specification, "-" shall mean a range including numerical values before and after it. In addition, numerical values expressed in % are values based on mass unless otherwise specified.

Component (A): Nicotinamide Component (A) nicotinamide (C6H6NO/molecular weight: 122.12) in the present invention is a water-soluble amide compound of nicotinic acid (vitamin B3, niacin). In the present invention, one extracted from rice bran or one synthesized can be blended. Specifically, those listed in the Japanese Pharmacopoeia 2008, 15th Edition can be used. Easily soluble in water and ethanol, but sparingly soluble in diethyl ether. It is known to be difficult to dissolve in polyhydric alcohols and oils.

The blending amount of component (A) is 1 to 10% by mass (hereinafter simply abbreviated as “%”). More preferably 3 to 8%. When the amount of component (A) is within this range, it is possible to obtain an effect in terms of improvement in rough skin and firmness/elasticity of the skin. Even if the content exceeds 10%, the effect tends to reach a peak, and in addition, crystals may precipitate when the water in the composition evaporates.

Component (B): Salt-tolerant water-soluble polymer The component (B) salt-tolerant water-soluble polymer in the present invention is water-soluble and exhibits sufficient viscosity even when electrolytes such as salts and metal oxides are dissolved in water. is a polymer of As a specific structure, a cellulose derivative, a cellulose derivative, a hydrophobically modified polyether urethane, a copolymer containing an acryloyldimethyltaurate salt as a monomer, a copolymer containing an acryloyldimethyltaurate salt as a monomer, etc. are preferably used. can be used, and can be contained singly or in an appropriate combination of two or more.

Cellulose derivatives include, for example, methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, hydroxypropylmethylcellulose stearoxyether, sodium carboxymethylcellulose (CMC), crystalline cellulose, and cellulose powders. Polymers are mentioned.

The hydrophobically modified polyether urethane used in the present invention is a polymer having urethane bonds modified with hydrophobic groups, and is preferably represented by the following chemical formula (I).
R ¹ -{(OR ² ) _k -OCONH-R ³ [-NHCOO-(R ⁴ -O) _n -R ⁵ ] _h } _m (I)
(In the formula, R ¹ represents a hydrocarbon group, R ² and R ⁴ each independently represent an alkylene group having 2 to 4 carbon atoms, R ³ may have a urethane bond, straight chain, branched chain or represents a hydrocarbon group containing an aliphatic ring or an aromatic ring, R ⁵ represents a hydrocarbon group having a branched chain; m is an integer of 2 or more, h is an integer of 1 or more, k and n are each independently an integer ranging from 0 to 1000 and k+n≧1).

A preferred example of a hydrophobically modified polyetherurethane is (PEG-240/decyltetradeceth-20/HDI) copolymer.

Copolymers containing acryloyldimethyltaurate as a monomer include (Na acrylate/Na acryloyldimethyltaurate) copolymer, (hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer, (ammonium acryloyldimethyltaurate/vinylpyrrolidone). copolymers, and the like.

Suitable commercially available salt-tolerant water-soluble polymers include hydroxypropyl methylcellulose stearoxy ether, Sangelose (manufactured by Daido Kasei Co., Ltd.), and (PEG-240/decyltetradeceth-20/HDI) copolymer. is ADEKA NOL GT-700 (manufactured by ADEKA CORPORATION), SIMULGEL EG (manufactured by Seppic Co., Ltd.) as a (Na acrylate/Na acryloyldimethyl taurate) copolymer, SEPINOV as a (hydroxyethyl acrylate/Na acryloyldimethyl taurate) copolymer Examples of EMT10 (manufactured by Seppic) and (acryloyldimethyltaurate ammonium/vinylpyrrolidone) copolymer include ARISTOFLEX AVC (manufactured by Clariant).

The content of component (B) is preferably 0.05 to 2%, more preferably 0.1 to 1.0%. Within this range, the effect of reducing stickiness and the effect of suppressing crystal precipitation are excellent.

Component (C): Phosphate ester-based surfactants include, but are not limited to, higher alcohol phosphates and/or salts thereof, higher alcohol ethylene oxide adduct phosphates and salts thereof.

A higher alcohol phosphate is a compound in which one or more of the three hydroxy groups of phosphoric acid are substituted with a higher alcohol residue. The higher alcohol phosphate may be in the form of a monoester, diester or triester, with the monoester being preferred.

The number of carbon atoms in the monohydric higher alcohol residue constituting the ester portion of the higher alcohol phosphate is preferably 8-30, more preferably 10-25, still more preferably 12-20. Furthermore, it may be a saturated hydrocarbon or an unsaturated hydrocarbon. The higher alcohol residue may be linear or branched, but is preferably linear.

Examples of higher alcohol phosphate salts include inorganic salts, organic amine salts, basic amino acid salts and the like. Examples of inorganic salts include alkali metal salts such as sodium salts and potassium salts. Examples of organic amine salts include monoethanolamine salts, diethanolamine salts, triethanolamine salts and the like.

Specific examples of higher alcohol phosphates or higher alcohol phosphate salts include sodium lauryl phosphate, disodium lauryl phosphate, potassium lauryl phosphate, cetyl phosphate, potassium cetyl phosphate, and diethanolamine cetyl phosphate. . Commercially available products include cetyl phosphate (trade name: "Hostaphat CC100" (manufactured by Clariant), potassium cetyl phosphate (trade name: "Hostaphat CK100" (manufactured by Clariant), "AMPHISOL K" (DSM Nutrition), etc.). is mentioned.

The higher alcohol ethylene oxide adduct phosphate ester is an ether phosphate ester composed of an ethylene oxide residue and a monohydric higher alcohol residue. The average number of moles of oxyalkylene added to ethylene oxide is, for example, 2-25, preferably 2-20.

The number of carbon atoms in the monohydric higher alcohol residue constituting the higher alcohol ethylene oxide adduct phosphate ester is preferably 8 to 30, more preferably 10 to 30, for example, lauryl group, cetyl group, stearyl group, oleyl group, etc. 25, more preferably 12-20 higher alcohol residues. Furthermore, it may be a saturated hydrocarbon or an unsaturated hydrocarbon. The monohydric higher alcohol hydrocarbon group may be linear or branched.

The higher alcohol ethylene oxide adduct phosphate ester may be monoester, diester or triester.

Examples of higher alcohol ethylene oxide adduct phosphate ester salts include inorganic salts, organic amine salts, basic amino acid salts and the like. Examples of inorganic salts include alkali metal salts such as sodium salts and potassium salts. Examples of organic amine salts include monoethanolamine salts, diethanolamine salts, triethanolamine salts and the like.

Specific examples of higher alcohol ethylene oxide adduct phosphates or higher alcohol ethylene oxide adduct phosphates include laureth-diphosphate, laureth-4 phosphate, dilaureth-10 phosphate, and trilaureth-4 phosphate. ethylene oxide lauryl ether phosphate such as ceteth-10 phosphate and ceteth-20 phosphate; ethylene oxide stearyl ether phosphate such as steareth-2 phosphate and steareth-3 phosphate; -ethylene oxide oleyl ether phosphate such as oleth-3 phosphate, oleth-4 phosphate, oleth-7 phosphate, oleth-8 phosphate, oleth-20 phosphate, dioleth-8 phosphate; triphosphate, (C12-15) pareth-6 phosphate, di(C12-15) pareth-4 phosphate, di(C12-15) pareth-6 phosphate, tri(C12-15) pareth-2 phosphate ethylene oxide alkyl (C12-15) ether phosphates such as; and salts thereof. Among them, ethylene oxide lauryl ether phosphate, ethylene oxide alkyl (C12-15) ether phosphate, ethylene oxide cetearyl ether phosphate, ethylene oxide oleyl ether phosphate, and salts thereof are preferred, and laureth-4 is more preferred. phosphoric acid, trilaureth-4 phosphate, (C12-15) pareth-3 phosphate, triceteareth-4 phosphate, oleth-3 phosphate, oleth-7 phosphate, oleth-20 phosphate, dioleth-8 phosphate, tri(C12-15) pareth-2 phosphate and salts thereof. Commercially available products thereof include oleth-3 phosphate under the trade name “Hostaphat O300” (manufactured by Clariant) and tri(C12-15) pareth-2 phosphate under the trade name “NIKKOL TDP-2” (Nikko Chemicals, Inc.). company) and the like.

Component (C) may be used alone or in combination of two or more.

The amount of component (C) is not particularly limited, but is preferably 0.1 to 3%, more preferably 0.2 to 2%, and more preferably 0.3 to 1%. be.

Component (D): Polyhydric alcohol The component (D) polyhydric alcohol in the present invention is blended to dissolve the component (A) and suppress crystal precipitation. A polyhydric alcohol alone has almost no crystal deposition suppressing effect, but good results can be obtained by using it in combination with a salt-tolerant water-soluble polymer. Component (D) is not particularly limited as long as it is commonly used in external compositions. Glycerin, diglycerin, saccharides and sugar alcohols with many hydroxyl groups may be used, and if necessary, one or more of them can be appropriately selected and used.

The content of component (D) is desirably 25% or less because if a large amount of polyhydric alcohol is added, stickiness tends to occur. On the other hand, in order to dissolve component (A) and suppress crystal precipitation, component (D) must be contained in an amount of 5% or more of the entire composition, and more than twice the amount of component (A). Crystal precipitation can be suppressed more preferably.

The external skin composition of the present invention contains the above components (A) to (D) to improve the firmness and elasticity of the skin, prevent and improve morphological changes due to aging such as wrinkles and sagging, and prevent irritation. It is possible to obtain a composition for external use on the skin that is excellent in use feeling without feeling or stickiness, and that is excellent in the effect of suppressing crystal precipitation and high-temperature emulsification stability.

In addition to the above components, the composition for external use on skin of the present invention contains optional components blended in ordinary compositions for external use on skin within the range that does not impair the effects of the present invention. , powder, film-forming agent, surfactant, oil-soluble gelling agent, organically modified clay mineral, resin, colorant, ultraviolet absorber, preservative, antibacterial agent, fragrance, antioxidant, pH adjuster, chelating agent , cosmetic ingredients, etc. can be added.

The composition for external use on skin of the present invention can be used in combination with other ingredients to form various dosage forms. Specifically, it can be implemented in various forms such as liquid, gel, paste, cream, solid, and sheet.

The composition for external use on the skin of the present invention is suitable for preparing quasi-drugs containing a large amount of nicotinic acid amide in anticipation of an anti-aging effect, in addition to cosmetics. Specifically, for example, it can be used in lotions, milky lotions, creams, beauty essences, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, and the like. The method of use includes methods such as using with hands, fingers, cotton, impregnating non-woven fabrics, and aerosolizing with a propellant.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these. Unless otherwise specified, the blending amount is shown in % by mass relative to the system in which the component is blended.

Experiment 1: Effect of nicotinamide on thickening agent Using 1% carbomer gel, the change in viscosity depending on the amount of nicotinamide blended was confirmed. Table 1 shows the results.
(experimental method)
A 1:1% carbomer aqueous solution was adjusted to pH 6.5 using potassium hydroxide and gelled to form a 1% carbomer gel.
2: A predetermined amount of nicotinic acid amide was added to the above 1% carbomer gel, dissolved uniformly, allowed to stand at 20°C for 4 hours, and the viscosity was measured. The degree of decrease in viscosity was calculated based on the formula (1).
(Measurement condition)
Measuring instrument: VISCOTESTER TVB-10 manufactured by Toki Sangyo Co., Ltd.
Measurement conditions: Rotor M3, rotation speed 12 rpm, after 60 seconds at 20°C

(Discussion)
In the low-concentration range where the amount of nicotinic acid amide blended did not reach 1%, the decrease in viscosity was small. Although nicotinamide is an electrolyte, it is suggested that it has relatively little effect on the viscosity reduction of water-soluble polymer gels that are sensitive to electrolytes, such as carbomer, which is widely used as a thickening stabilizer for cosmetics. rice field. However, this experiment shows that when the blending amount exceeds 1% and the concentration becomes high, a clear decrease in viscosity occurs. Therefore, there was a concern that poor stability such as separation is likely to occur.
Incidentally, when the same test was conducted using sodium chloride, the results were as follows.
When 0.1% sodium chloride, which is a typical electrolyte, is added to 1% carbomer gel, the viscosity is 35.3 mPa.s. s (measurement conditions: rotor M1, number of rotations 60 rpm, after 60 seconds at 20°C) degree of viscosity reduction = 99.4%

Products 1 to 10 of the present invention and comparative products 1 to 11: Oil-in-water emulsified cream An oil-in-water emulsified cream having the formulation shown in Table 2 below was prepared, and the effect of suppressing skin firmness/elasticity, stickiness, and crystal precipitation was evaluated by the following method. Evaluated by The results are also shown in Table 2.

(Evaluation item)
Firmness and elasticity of skin No stickiness Emulsion stability at high temperature

(Evaluation method)
[Method for sensory evaluation of skin firmness, elasticity, and lack of stickiness]
Evaluation was performed by 10 professional panelists who were women in their 20s to 40s who had undergone sensory evaluation training. For each sample, an expert panelist evaluated the stickiness immediately after application to the skin and the firmness and elasticity of the skin felt the next morning.
Five-level evaluation was performed in the following absolute evaluation, the average value was calculated, and evaluation was made according to the following four-level criteria.

(Evaluation method for skin firmness and elasticity)
(score): (evaluation)
5 points: I feel that my skin has a lot of firmness and elasticity.
4 points: I feel that my skin has firmness and elasticity.
3 points: normal (no change felt)
2 points: Somewhat dissatisfied with skin firmness and elasticity, not desirable
1 point: Skin firmness and elasticity are not felt 4-step judgment criteria (Judgment): (Average score)
◎ : 4 points or more
○: 3 points or more to less than 4 points
△: 2 points or more to less than 3 points
×: Less than 2 points

(Evaluation method for lack of stickiness)
(score): (evaluation)
5 points: Does not feel sticky
4 points: hardly feels sticky
3 points: Slightly sticky
2 points: feels sticky
1 point: Feels very sticky 4-step judgment criteria (Judgment): (Average score)
◎ : 4 points or more
○: 3 points or more to less than 4 points
△: 2 points or more to less than 3 points
×: Less than 2 points

[Evaluation method of crystal precipitation suppression effect]
For the evaluation of the effect of suppressing crystal precipitation, 4 g of the sample was applied to the bottom of a sterilized petri dish (made of polystyrene: 90 mm Φ x 15 mm), and allowed to stand in an open state (with no lid) in a 30°C incubator for 24 hours. Each sample was then observed under a microscope. The state of crystal precipitation was observed with a 40x optical microscope using a polarizing filter.
<Judgment Criteria>
(judgment): (evaluation)
A: No precipitation of crystals.
◯: Slight precipitation of crystals is observed.
x: Precipitation of crystals is clearly observed.

[Evaluation method for emulsion stability at high temperature]
(Evaluation of emulsion stability)
The samples of Examples 1 to 1 and Comparative Examples 1 to 1 were stored under a temperature condition of 60° C. for 2 weeks, visually observed for changes in appearance, and judged according to the following 3-step evaluation criteria.
Three-stage judgment criteria (judgment): (evaluation result)
◎: no change, uniform: very good ○: no change in 1 week, separation observed after 2 weeks: good ×: separation observed within 1 week: poor

Potassium cetyl phosphate *1 AMPHISOL K DSM Nutrition Tri (C12-15) pareth-2 phosphate *2 NIKKOL TDP-2 37.5% (Na acrylate/Na acryloyldimethyltaurate) copolymer/isohexadecane manufactured by Nikko Chemicals / Polysorbate 80 / water mixture * 3 SIMULGEL EG: (PEG-240 / decyltetradeceth-20 / HDI) copolymer manufactured by Sepik * 4 Adekanol GT-700: Hydroxypropyl methylcellulose stearoxy ether manufactured by Adeka * 5 Sangelose 60L: manufactured by Daido Kasei Co., Ltd.

Production method (a): 1 to 10 are uniformly dissolved and mixed at 70°C.
(b): Other ingredients are added to the purified water of 24 in sequence, and dissolved and mixed uniformly at 70°C.
(c): (a) is added to (b) and emulsified at 70°C.
(d): Stir and cool to 40° C. to obtain the desired composition.

As is clear from the results in Table 2, the external skin compositions of Examples 1 to 8 of the present invention are superior to the skin external compositions of Comparative Examples 1 to 7 in skin firmness/elasticity, lack of stickiness, and crystallinity. Good results were obtained in all of the inhibitory effects and the aging stability tests at 60°C for 2 weeks.
On the other hand, the comparative products 1 and 2 containing no (C) phosphoric acid-based surfactant were subjected to stability over time, and significant separation was observed after 2 days. (A) Comparative Example 3, in which nicotinic acid amide was not blended, was low in evaluation of firmness and elasticity of the skin. (B) Comparative Example 4, in which no salt-tolerant polymer was blended, had poor stability over time, and separation was observed on the next day, and crystal precipitation was also observed. In Comparative Example 5 in which (D) polyhydric alcohol/(A) nicotinamide is 1, crystal precipitation was observed. (B) Comparative Example 6, in which carbomer, which is a general thickening agent, was used instead of the salt-tolerant water-soluble polymer was similarly in a satisfactory state after production, but the stability over time was confirmed. Separation has occurred. Crystal precipitation also occurred. (D) In Comparative Example 7, in which ethanol, which is a monohydric alcohol, was blended instead of the polyhydric alcohol, the feeling of use was good with little stickiness, but crystal precipitation occurred.

Example 9: Oil-in-water sunscreen cream (ingredient) (mass%)
1.1,3-butylene glycol 12.0
2. Diglycerin 3.0
3. Purified water Appropriate amount 4. Nicotinamide 6.0
5. Methyl paraoxybenzoate 0.1
6. Sucrose stearate 1.0
7. (Hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer *3 0.1
8. Xanthan gum 0.05
9.30% dilauroyl glutamate lysine Na aqueous solution 0.3
10. Glyceryl monostearate 1.5
11. Sorbitan sesquioleate 0.3
12. Hydrogenated lecithin 0.1
13. Di(phytosteryl/octyldodecyl) lauroyl glutamate 3.0
14. Diethanolamine cetyl phosphate *6 0.5
15. Ethylhexyl methoxycinnamate 5.0
16. Diethylaminohydroxybenzoyl hexyl benzoate 1.0
17. Jojoba oil 5.0
18. Shea butter 2.0
19. Squalane 1.0
20. Ceramide 3 0.1
21. Tocopherol 0.05
22. Cetostearyl alcohol 2.0
23. Cholesterol 0.3
24. Ubiquinone 0.001
25. Hydrogenated polyisobutene 2.0
26.40% polyacrylamide solution 0.3

(Hydroxyethyl acrylate/Na acryloyldimethyltaurate) copolymer *3 SEPINOV EMT10: diethanolamine cetyl phosphate manufactured by Seppic *6 AMPHISOL (manufactured by DSM Nutrition)

(Production method)
(a): Components 1 to 9 are uniformly dissolved and mixed at 70°C.
(b): Components 10 to 25 are uniformly dissolved and mixed at 80°C.
(c): Add (b) to (a) and emulsify at 70°C.
(d): Add 26 to (c) and mix until uniform.
(e): Cooled to 40°C to obtain an oil-in-water sunscreen cream.

The oil-in-water emulsified milky lotion of Example 9 was a composition for external use on the skin that was excellent in skin firmness/elasticity, stickiness, effect of suppressing crystal precipitation, and stability over time.

Example 10: Oil-in-water emulsified beauty essence (component) (% by mass)
1.1,3-butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Xylitol 3.0
4. Purified water Appropriate amount5. Nicotinamide 4.0
6. (Acrylates/alkyl acrylate (C10-30)) crosspolymer
0.1
7.92% (acryloyldimethyltaurate ammonium/VP) copolymer/(t-butanol/water mixture) *7 0.1
8. Coconut fatty acid polyoxyethylene sorbitan (20 E.O.) 0.5
9. Macadamia nut oil fatty acid phytosteryl 2.0
10. Light liquid isoparaffin 3.0
11. Dimethylpolysiloxane (5CS) 3.0
12. Oleth-3 phosphate 0.2
13. Polyglyceryl-5 myristate 1.0
14. Tocopherol 0.1
15. Stearyl glycyrrhetinate 0.05
16.10% sodium hydroxide aqueous solution 0.5
17. Phenoxyethanol 0.2
18. Ethanol 5.0
19.0.3% water-soluble collagen aqueous solution 0.1
20.0.4% water-soluble elastin aqueous solution 0.1
21.1% sodium hyaluronate aqueous solution 0.1
22. Tremella fungus polysaccharide 0.1

92% (acryloyldimethyltaurate ammonium / VP) copolymer (t-butanol / water mixture) * 7 ARISTOFLEX AVC: Oleth-triphosphate manufactured by Clariant * 8 Hostaphat O300 manufactured by Clariant

(Production method)
(a): Components 1 to 8 are uniformly dissolved and mixed at 70°C.
(b): Components 9 to 15 are uniformly dissolved and mixed at 80°C.
(c): Add (b) to (a) and emulsify at 70°C.
(d): After starting cooling of (c), components 18 to 22 were sequentially added at 45°C, and then cooled to 40°C to obtain an oil-in-water emulsified beauty essence.

The oil-in-water emulsified beauty essence of Example 10 was an external composition for skin that was excellent in firmness/elasticity of the skin, stickiness, effect of suppressing crystal precipitation, and stability over time.

Example 11: Water-based moisturizing gel (component) (% by mass)
1.1,2 pentanediol 0.5
2.1,3 Butylene Glycol 12.0
3. Methyl gluceth-10 3.0
4.37.5% (Na acrylate/Na acryloyldimethyltaurate) copolymer/isohexadecane/polysorbate 80/water mixture *3 0.3
5.5% polyquaternium-51 aqueous solution 0.3
6. Sodium hyaluronate 0.01
7. (PEG-240/decyltetradeceth-20/HDI) copolymer *7
0.7
8. Nicotinamide 3.0
9. Dipotassium glycyrrhizinate 0.1
10. Carbomer 0.1
11.10% potassium hydroxide aqueous solution 1.0
12. Potassium cetyl phosphate 0.2
13. PEG-100 hydrogenated castor oil 0.5
14. Ethylhexylglycerin 0.3
15. Purified water Appropriate amount

(PEG-240 / decyltetradeceth-20 / HDI) copolymer * 7 Adekanol GT-700: Potassium cetyl phosphate manufactured by Adeka AMPHISOL K * 1 manufactured by DSM Nutrition

(Production method)
(a): Ingredients 12 to 14 are heated and dissolved in advance.
(b): To component 15, components (a) and each of components 1 to 11 were added and mixed, and the mixture was stirred until transparent and uniform to obtain a water-based moisturizing gel.

The water-based moisturizing gel of Example 11 was an external composition for skin that was excellent in firmness/elasticity, stickiness, effect of suppressing crystal precipitation, and stability over time.

Example 12: Sheet mask (Nonwoven fabric impregnated serum)
(Component) (% by mass)
1.1,2-hexanediol 0.5
2.1,3-butylene glycol 10.0
3. Methyl gluceth-10 1.0
4. (Acrylates/alkyl acrylate (C10-30)) crosspolymer
0.05
5.37.5% (Na acrylate/Na acryloyldimethyltaurate) copolymer/isohexadecane/polysorbate 80/water mixture *3 0.1
6. Xanthan gum 0.2
7. PEG/PPG/polybutylene glycol-8/5/3 glycerin 0.3
8. Sodium hyaluronate 0.01
9. Nicotinamide 7.0
10. Starch Octenyl Succinate Al 0.5
11. Dipotassium glycyrrhizinate 0.1
12. Glycerin 5.0
13. δ-tocopherol 0.05
14. Cetyl phosphate 0.1
15. PPG-6 decyltetradeceth-30 0.5
16. Ethylhexylglycerin 0.2
17. Methylparaben 0.1
18. Purified water Appropriate amount 19.10% potassium hydroxide aqueous solution 0.2
Cetyl phosphate Hostaphat CC100*9 Clariant Co., Ltd. 37.5% (Na acrylate/Na acryloyldimethyltaurate) copolymer/isohexadecane/polysorbate 80/water mixture *3 SIMULGEL EG: Sepik Co., Ltd.

(Production method)
(a): Ingredients 12 to 17 are heated and dissolved in advance.
(b): Component (a) and each of components 1 to 11 were added to component 18, mixed and stirred until uniform to obtain a beauty essence.
(c): 19 was added to (b) and mixed to prepare a stock solution for a sheet mask.
(d): Impregnate 30 g of this serum into a face-shaped non-woven fabric (500 cm2, basis weight 60 g/m2, rayon/polypropylene = 70%/30%), fill it in an aluminum sheet bag, and prepare a sheet mask. did.

The sheet mask of Example 12 was excellent in stability over time, with no skin firmness/elasticity, no stickiness, and no precipitation of crystals during use.

Example 13: All-in-one gel (component) (mass%)
1. Diisostearyl malate 1.0
2. behenyl alcohol 1.0
3. Cetyl ethylhexanoate 4.0
4. Dimethicone 1.5
5. Squalane 4.0
6. Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) 1.0
7. Potassium cetyl phosphate 1.0
8. Sorbitan sesquioleate 0.8
9. Sucrose stearate 2.0
10. Polyglyceryl-10 stearate 1.5
11. PEG-50 hydrogenated castor oil 1.0
12. Tocopherol 0.1
13. water appropriate amount 14.1,3-butylene glycol 10.0
15. Hydroxypropyl methylcellulose stearoxy ether *5 0.1
16. Glycerin 15.0
17. Carbomer 0.1
18. EDTA-2Na 0.005
19. Propynyl iodide butylcarbamate 0.003
20. Ethylhexylglycerin 0.2
21. Niacinamide 4.0
22. Phenoxyethanol 0.2
23. Polymethyl methacrylate 2.0
24. Retinol palmitate/corn oil mixture 0.001
25.10% arginine aqueous solution 1.0
26. Sodium glutamate 0.01
27. Creatinine 0.01
28. Centella asiatica extract 0.01
29. Hibiscus flower extract 0.01
30. Hydrolyzed hyaluronic acid 0.01
31. Comfrey leaf extract 0.01
32. Hydrolyzed elastin 0.01
33. Hydrolyzed soy protein 0.01
34. Mandarin orange peel extract 0.01
35. Lactobacillus / pear juice fermentation liquid 0.01
36. Pearl barley seed extract 0.01
37. Alpinia purpurea leaf extract 0.01

Potassium cetyl phosphate AMPHISOL K*1 Hydroxypropyl methylcellulose stearoxy ether *5 manufactured by DSM Nutrition Co., Ltd. Sangelose 60L: manufactured by Daido Kasei Co., Ltd.

(Production method)
(a): Components 1 to 12 are uniformly dissolved and mixed at 70°C.
(b): Components 13 to 24 are uniformly dissolved and mixed at 80°C.
(c): (a) is added to (b) and emulsified at 70°C.
(d): After starting cooling of (c), components 25 to 37 were sequentially added at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsified beauty essence.

The all-in-one gel of Example 13 was an external composition for skin that was excellent in firmness/elasticity of the skin, stickiness, effect of suppressing crystal precipitation, and stability over time.

Example 14: Oil-in-water emulsified beauty essence (multiple extract-containing beauty essence)
(Component) (% by mass)
1.1,3-butylene glycol 9.0
2. Diglycerin 5.0
3. Maltose 3.0
4. Purified water Appropriate amount5. Nicotinamide 4.0
6. Polyvinyl alcohol 0.1%
7. (Hydroxypropyl methylcellulose stearoxy ether *2 0.1
8. PEG-50 hydrogenated castor oil 2.0
9. dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl) 2.0
10. Diphenylsiloxyphenyl trimethicone 3.0
11. Hydrogenated polyisobutene 3.0
12. Oleth-3 phosphate 0.2
13. Sorbitan sesquioleate 0.8
14. Stearyl glycyrrhetinate 0.05
15. Tocopherol 0.1
16. Phenoxyethanol 0.2
17. Rose extract 0.01
18. Sakura extract 0.01
19. Lily extract 0.01
20. Shimahozuki extract 0.01
21. zedoary extract 0.01
22. Tea extract 0.01
23. Rhubarb extract 0.01
24. Angelica extract 0.01
25. Hibiscus extract 0.01
26. Tormentilla extract 0.01
27. Baobab extract 0.01
28. Ireisen extract 0.01
29. Sunflower extract 0.01
30. Kusuri extract 0.01
31. Glycyrrhiza extract 0.01
32. Safflower extract 0.01
33. Ginseng extract 0.01
34. Hatomugi extract 0.01
35. horsetail extract 0.01
36. Ginkgo biloba extract 0.01
37. Jojoba extract 0.01
38. Terminalia extract 0,01
39. Chickweed extract 0.01
40. Corn extract 0.01
41. Honeycomb extract 0.01
42. Pomegranate extract 0.01
43. Phellinus linteus extract 0.01
44. Rosehip extract 0.01
45. Evening primrose extract 0.01
46. Chamomile extract 0.01
47. Soybean extract 0.01
48. White bean extract 0.01
49. Mandarin orange extract 0.01
50. Magnolia extract 0.01
51. Black carrot extract 0.01
52. White strawberry extract 0.01
53. Himalayan raspberry extract 0.01
54. Silk tree extract 0.01
55. Sweet marjoram extract 0.01
56. Modama extract 0.01
57. Comfrey leaf extract 0.01
58. Saccharomyces/day lily flower fermentation liquid 0.01
59. Alpinia purpurea leaf extract 0.01
60. Murasakishibu fruit extract 0.01
61. Fucus extract 0.01
62. Hydrolyzed soy protein 0.01
63. Tabebuia impetiginosa bark extract 0.01
64. Glucosyl hesperidin 0.01

Hydroxypropyl methylcellulose stearoxy ether *2 Sangelose 60L: Oleth-3 phosphate Hostaphat O300*10 manufactured by Daido Kasei Co., Ltd. Clariant

(Production method)
(a): Components 1 to 7 are uniformly dissolved and mixed at 70°C.
(b): Components 8 to 16 are uniformly dissolved and mixed at 80°C.
(c): Add (b) to (a) and emulsify at 70°C.
(d): After starting cooling of (c), components 17 to 64 were sequentially added at 45°C, and then cooled to 35°C to obtain an oil-in-water emulsified beauty essence.

The oil-in-water emulsified beauty essence of Example 14 was an external composition for skin that was excellent in firmness/elasticity of the skin, stickiness, effect of suppressing crystal precipitation, and stability over time.

INDUSTRIAL APPLICABILITY The present invention can be applied to cosmetics, quasi-drugs, external preparations for skin, and the like.

Claims (5)

the following components (A)-(D);
(A) Nicotinamide 1 to 10% by mass
(B) salt-tolerant water-soluble polymer 0.05 to 2% by mass
(C) phosphate ester surfactant (D) polyhydric alcohol 5 to 25 mass%
A composition for external use on the skin, comprising: The blending mass ratio of component (D) and component (A) is
2. The external composition for skin according to claim 1, wherein (D)/(A)≧2. 3. The salt-tolerant water-soluble polymer of component (B) is one or more selected from cellulose derivatives, hydrophobically modified polyether urethanes and copolymers containing acryloyldimethyltaurate as monomers. The composition for external use on skin according to any one of the above. The salt-tolerant water-soluble polymer of component (B) is hydroxypropyl methylcellulose stearoxy ether, (PEG-240/decyltetradeceth-20/HDI) copolymer, (Na acrylate/Na acryloyldimethyltaurate) copolymer, (acrylic acid 5. The composition for external use on skin according to any one of claims 1 to 4, which is at least one selected from hydroxyethyl/acryloyldimethyltaurate Na) copolymer and (acryloyldimethyltaurate ammonium/vinylpyrrolidone) copolymer. A sheet-like external skin preparation impregnated with the external skin composition according to any one of claims 1 to 5.