JP2720247B2 - External preparation for skin - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin, and more particularly, to an external preparation for skin having an excellent function of preventing skin spots and freckles.

[0002]

BACKGROUND OF THE INVENTION Vitamin C or its derivatives, licorice extract, placenta extract, hydroquinone glycoside, glutathione, etc. are known as agents for preventing the formation of spots and freckles. It is blended.

[0003]

However, many of these have the effect of suppressing the production of melanin, which is the cause of spots and freckles, but have almost no effect of suppressing skin damage due to ultraviolet irradiation, and the ultraviolet irradiation has a long-term effect. When it reaches the skin, the function which the skin should have is deteriorated, which causes a large amount of spots and freckles.

[0004]

In view of the above circumstances, the present inventors have conducted intensive studies to obtain a skin external preparation which has a high whitening effect and is excellent in preventing spots and freckles due to ultraviolet rays. The inventors have found that the above problems can be solved by using trehalose and a whitening agent in combination, and have completed the present invention. That is, the present invention is an external preparation for skin, comprising trehalose and at least one whitening agent.

Hereinafter, the configuration of the present invention will be described in detail. Examples of the whitening agent used in the present invention include vitamin C or a derivative thereof, sodium ascorbate, disodium L-ascorbate, ascorbyl dipalmitate, ascorbyl palmitate, stearyl ascorbate, magnesium L-ascorbyl phosphate, and the like. , Licorice extract, placenta extract, arbutin, which is a glycoside of hydroquinone, and glutathione. The amount of the whitening agent used in the present invention is 0.01 to 20% by weight, preferably 0.05 to 10% by weight, based on the total amount of the external preparation for skin.
It is. If the content is less than 0.01% by weight, the effect is not exhibited.
The effect is not increased even if it exceeds 20% by weight.

The trehalose according to the present invention is a disaccharide in which two D-glucoses are bound, and the binding mode is α, α-, α, β-, β, β- To
In general, the α, α-bonding mode, which is frequently present, is used. The amount of trehalose used in the present invention is 0.01 to 30% by weight, preferably 0.05 to 20% by weight, based on the total amount of the external preparation for skin. If it is less than 0.01% by weight, it tends to be difficult to sufficiently prevent stains and freckles.

[0007] In addition to the above-mentioned essential components, the skin external preparation of the present invention may, if necessary, contain other components usually used in skin external preparations such as pharmaceuticals and cosmetics, such as liquid paraffin, petrolatum, and microcrystalline wax. , Squalane, almond oil, olive oil, hydrogenated oil, castor oil,
Mocro, coconut oil, beeswax, lanolin, carnauba wax, oils such as palm oil, lanolinic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, fatty acids such as oleic acid, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, cholesterol Higher alcohols such as isopropyl myristate,
Esters such as myristyl myristate and isopropyl palmitate, acids such as citric acid, tartaric acid and lactic acid, alkalis such as sodium hydroxide, potassium hydroxide and triethanolamine, betaine lauryldimethylaminoacetate, glyceryl monostearate, and sorbitan fatty acid Ester, polyoxyethylene fatty acid ester, surfactant such as polyoxyethylene alkyl ether, glycerin,
Propylene glycol, 1,3-butylene glycol,
Moisturizers such as dipropylene glycol, sorbitol, sodium pyrrolidonecarboxylate, polyethylene glycol, hyaluronic acid, powders such as talc and calcium carbonate,
Preservative disinfectants such as parabens, thickeners such as carboxymethylcellulose, sodium alginate, carboxyvinyl polymers, coloring agents such as yellow iron oxide, titanium yellow, and carthamine, photosensitizers, carrots, aloe, mallow, iris, grapes, yoquinin, and melissa And extracts such as Yarrow, Yarrow, Luffa, Lily, Psyllium, Peony, Assembly, Birch, Loquat, and vitamins such as nicotinamide. Naturally, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.

[0008] The dosage form of the external preparation for skin of the present invention is arbitrary,
Solution system, solubilization system, emulsification system, powder dispersion system, water-two-layer system,
Any dosage form, such as a water-oil-powder three-layer system, may be used.
The use of the external preparation for skin of the present invention is also optional, and lotions, emulsions, creams, facial cosmetics such as packs,
It can be used for makeup cosmetics such as foundations, lipsticks, eye shadows, etc., body cosmetics, and aromatic cosmetics.

[0009]

The external preparation for skin of the present invention has an excellent effect of preventing skin spots and freckles.

[0010]

EXAMPLES Next, the present invention will be specifically described with reference to examples. The present invention is not limited by this. The compounding amount is% by weight. The whitening effect was determined from use tests such as the skin whitening effect by cumulative application and the removal of spots and freckles.

Whitening effect test by cumulative application One group of test subjects working outdoors mainly exposed to ultraviolet rays
One sample cream was applied daily to the face for three months (June to August) in the morning and evening, and the whitening effect was examined at the third month. The criteria are shown in Table 1, and the prescriptions for examination are shown in Table 2. The formulations in Table 2 were manufactured by a conventional method. Table 3 shows the results of the whitening effect test by the cumulative application.

[0012]

[Table 1]

[0013]

[Table 2]

[0014]

[Table 3]

As is clear from Table 3, the examples of the present invention are excellent in the effect of preventing generation of spots and freckles due to irradiation with ultraviolet rays.

Example 2 Lotion Lotion was prepared according to the following formulation by a conventional method. Ethanol 5.0 Glycyrrhizic acid 0.1 Polyoxyethylene (20 mol) oleyl ether 0.3 Methyl parahydroxybenzoate 0.2 Perfume Appropriate amount Cyclodextrin 1.0 Propylene glycol 5.0 Trehalose 1.0 Polyethylene glycol 2.0 Glycerin 5.0 Arbutin 1.5 Chondroitin sulfate sodium 0.3 Inosit 0.05 Sodium metaphosphate 0.05 Colorant Appropriate amount Deionized water remaining

Example 3 Emulsion An emulsion was prepared according to the following formulation by a conventional method. Liquid paraffin 10.0 Lanolin alcohol 0.5 Lanolin fatty acid glyceryl 2.0 Stearic acid 2.5 Oil-soluble licorice extract 0.1 Stearyl glycyrrhetinate 0.1 Ethyl parahydroxybenzoate 0.2 Glycerin 3.0 Propylene glycol 3.0 Trehalose 0.1 Triethanolamine 1.0 Adenosine triphosphate 0.1 Pyridosine hydrochloride 0.03 Flavoring amount Appropriate ion exchange water Remaining amount

Example 4 Cream A cream was produced according to the following recipe by a conventional method. Stearyl alcohol 15.0 Beeswax 8.0 Sorbitan monooleate 1.25 Polyoxyethylene sorbite oleate 3.75 Ethyl paraoxybenzoate 0.2 Evening primrose oil 0.1 Pyridoxine 0.01 Trehalose 2.0 Water-soluble placenta extract 0.1 Sorbitol solution (70%) 7.5 Hyaluronic acid 0.05 Allantoin 0.1 Ion-exchanged water residue amount

Example 5 Sun care According to the following formulation, sun care was produced by a conventional method. Myristyl alcohol 3.0 Ethyl paraaminobenzoate 1.5 Methyl glucoside sesquistearate 6.0 Polyethylene glycol lanolin fatty acid 3.0 Ethyl paraoxybenzoate 0.2 Ascorbyl palmitate 2.0 Perfume Appropriate amount Glycerin 5.0 Propylene glycol 5.0 Trehalose 4.0 Ion-exchanged water Remaining amount

Example 6 Foundation A foundation was prepared according to the following formulation by a conventional method. Isostearic acid 4.0 Oleyl alcohol 0.5 Vaseline 2.0 Squalane 15.0 Diglyceryl diisostearate 0.1 Butyl paraoxybenzoate 0.1 dl-α-tocopherol acetate 0.01 Fragrance Appropriate amount Talc 5.0 Titanium oxide 5.0 Bengala 0.8 Yellow iron oxide 1.3 Kaolin 7.0 Propylene glycol 5.0 Polyethylene glycol 5.0 Trehalose 3.0 Magnesium phosphate L-ascorbyl 0.5 Potassium hydroxide 0.5 Synthetic sodium / magnesium 0.1 Ion-exchanged water Remaining amount The external preparations for skin of Examples 2 to 6 are excellent in the effect of preventing skin spots and freckles due to ultraviolet rays. Was.

Continued on the front page (51) Int.Cl. ⁶ Identification number Agency reference number FI Technical display location A61K 7/42 A61K 7/42

Claims (1)

(57) [Claims] An external preparation for skin, comprising trehalose and at least one whitening agent.