JP2003081805A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation comprising a 2-O-α-D- glucopyranosyl-L-ascorbic acid derivative imparting the firmness and elasticity of the skin from the interior and exterior of the skin and formulated therein. SOLUTION: This skin care preparation is obtained by formulating one or more kinds selected from the group consisting of collagen and collagen hydrolyzed proteins with the 2-O-D-glucopyranosyl-L-ascorbic acid derivative.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation,
More specifically, the present invention relates to an external preparation for skin that gives skin elasticity and elasticity.

[0002]

BACKGROUND OF THE INVENTION Collagen is a substance that controls the elasticity of the skin. Therefore, in order to give more elasticity to the skin,
It is known to add collagen to a skin external preparation. It is also known that vitamin C, that is, ascorbic acid, is involved as a substance that promotes the production of collagen inside the skin.

[0003]

However, when collagen is mixed with cosmetics, the skin's elasticity and elasticity can be improved, but since collagen cannot enter inside the skin, Elasticity is temporary. On the other hand, it is known that ascorbic acid, which is involved in promoting collagen production inside the skin, has extremely poor stability and decomposes over time. As a result, even if incorporated into a cosmetic, it decomposes over time and cannot reach the inside of the skin sufficiently. Therefore, there is a drawback that the collagen production promoting effect, which is one of the functions of ascorbic acid in the living body, is not sufficiently exhibited. Further, even if a large amount of ascorbic acid is blended, the inherent toxicity of ascorbic acid adversely affects the skin.

[0004]

[Means for Solving the Problems] Ascorbic acid glucoside derivative, which is one of the ascorbic acid derivatives, is much more stable than ascorbic acid, and when incorporated into cosmetics, it can reach the inside of the skin sufficiently. , The effect of promoting collagen production is fully exerted. It is also known that this derivative is not as toxic as ascorbic acid when applied to the skin in a large amount. However, even if 2-OD-glucopyranosyl-L-ascorbic acid, which is an ascorbic acid derivative, is blended in a cosmetic composition and applied to the skin, it has no immediate effect and needs to be used for a long time. Therefore, by simultaneously blending collagen that is directly involved in the skin's elasticity, it has an immediate effect on the skin's elasticity and elasticity, and it can be used for a long period of time to promote collagen production by 2-OD-glucopyranosyl-L-ascorbic acid. The present invention has been completed by finding that it is possible to provide elasticity and elasticity from the inside of the skin by the effect.

That is, the present invention is characterized by blending one or two or more kinds selected from the group consisting of collagen and collagen-degrading proteins, and a 2-OD-glucopyranosyl-L-ascorbic acid derivative. It is a skin external preparation. According to the present invention, by combining a 2-OD-glucopyranosyl-L-ascorbic acid derivative that gives collagen to bring about skin tone to the skin and promotes collagen production inside the skin, further skin tone and elasticity are obtained. Can be given.

The amount of the collagen or collagen-degrading protein used in the present invention is preferably 0.001 to 20% by mass as the dry residue, more preferably 0.01 to 20% by mass in the total amount of the external preparation for skin. It is 15% by mass. If the content of collagen or collagen-degrading protein is less than 0.001% by mass as a dry residue, the elasticity of the skin and the effect of giving a swelling are insufficient, and 20% by mass
If it is blended in excess of 3, the stickiness will be strong and the usability will be poor.

The 2-O-α-D-glucopyranosyl-L-ascorbic acid used in the present invention is a glycoside of ascorbic acid, and can be produced, for example, by the method described in JP-A-3-135992. You can The compounding amount of 2-OD-glucopyranosyl-L-ascorbic acid in the present invention is 0.0005 in the total amount of the skin external preparation.
To 5.0 mass% is preferable, and 0.00 is more preferable.
It is 1 to 2.0 mass%. The compounding amount of 2-OD-glucopyranosyl-L-ascorbic acid is 0.0005% by mass.
If the amount is less than 5.0%, the elasticity of the skin and the effect of providing the suppleness due to continuous use are insufficient, and if it exceeds 5.0% by mass, the usability becomes poor.

The external preparation for skin of the present invention comprises cosmetics, pharmaceuticals,
Quasi-drugs, etc. refers to those applied to the outer skin, and the dosage forms are aqueous system, solubilization system, emulsion system, powder system, oil liquid system, gel system, ointment system, water-oil two-layer system, water. It can take a wide variety of forms such as oil-powder tri-layer system.

The external preparation for skin of the present invention may contain, in addition to the above-mentioned essential components, other components which are usually used for external preparations for skin such as cosmetics and pharmaceuticals, within a range that does not impair the effects of the present invention. For example, powder components such as titanium dioxide, mica, talc, silicone, nylon, cellulose, avocado oil, corn oil, olive oil, rapeseed oil, evening primrose oil, castor oil, sunflower oil, tea seed oil, rice bran oil, jojoba oil, cacao. Oil, coconut oil, squalane, squalene, beef tallow, owl, beeswax, candelilla wax, carnauba wax, whale wax, lanolin, silicone oil, fusso oil, liquid paraffin, ceresin, petrolatum, polyoxyethylene (8 mol) oleyl alcohol ether, Oils such as pentaerythritol ethylhexanoate, glyceryl ethylhexanoate, cetyl ethylhexanoate, glyceryl monooleate, higher alcohols such as capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol Moisturizing sterols such as phytosterol, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, higher fatty acids such as linolenic acid, polyethylene glycol, glycerin, sorbitol, xylitol, maltitol, etc. Agent, methyl cellulose, ethyl cellulose, gum arabic, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyvinyl alcohol, montmorillonite, laponite and other thickeners, ethanol and other organic solvents, butylhydroxytoluene, tocopherol, phytic acid and other antioxidants , Benzoic acid, salicylic acid, sorbic acid, paraoxybenzoic acid alkyl ester (ethyl paraben, butyl paraben, etc.), hexachlorophen, etc. Down,
Alanine, valine, leucine, serine, threonine, phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine, histidine and other amino acids and their alkali metal salts and hydrochlorides,
Acyl sarcosine acid (eg sodium lauroyl methyl sarcosine), glutathione, organic acids such as malic acid, vitamin A and its derivatives, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ and its Vitamin B such as derivatives, vitamin B ₁₂ , vitamin B ₁₅ and its derivatives
, Ascorbic acid, ascorbic acid sulfate (salt), ascorbic acid phosphate (salt), vitamin C such as ascorbic acid dipalmitate, α-tocopherol, β-tocopherol, γ-tocopherol,
Vitamin E acetate, vitamin E nicotinate and other vitamin Es, vitamin D, vitamin H, pantothenic acid, pantethine and other vitamins, nicotinic acid amide, benzyl nicotinate, γ-oryzanol, allantoin,
Glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol, thymol, inositol, saponins (saikosaponin, carrot saponin, hechimasaponin, muclodisaponin, etc.), pantothenethyl ether, ethinyl estradiol , Cepharanthin, placenta extract, photosensitizer, arbutin, kojic acid, tranexamic acid, various drugs, Rumex, Clara, kohone,
Organic solvents of plants such as orange, sage, yarrow, mallow, senkyu, senburi, thyme, spruce, spruce, birch, horsetail, loofah, horse chestnut, yukinoshita, arnica, lily, mugwort, peony, aloe, gardenia, alcohol, polyvalent Natural extracts extracted with alcohol, water, aqueous alcohol, etc., pigments, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyethylene Glycol monooleate, polyoxyethylene alkyl ether, polyglycol diether, lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hydroxy Fatty acid ether, alkylated polysaccharide,
Alkyl glucoside, nonionic surfactants such as sugar ester, stearyl trimethyl ammonium chloride, benzalkonium chloride, cationic surfactants such as lauryl amine oxide, sodium palmitate, sodium laurate, sodium lauryl sulfate,
Anionic surfactants such as potassium lauryl sulphate, alkylsulfuric acid triethanolamine ether, funnel oil, linear dodecylbenzene sulphate, polyoxyethylene hydrogenated castor oil maleic acid, acylmethyl taurine, amphoteric surfactants, fragrances, purified water It can be blended.

[0010]

EXAMPLES Next, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto. Note that "%" means "mass%". Prior to the examples, the test methods and evaluation methods used in the present invention will be described.

(1) A test sample was applied by hand to the upper arm of 20 female sticky panelists,
The stickiness after application was surveyed and evaluated according to the following criteria. ◎: 16 or more panelists who answered that they were not sticky or slimy. ○: 12 to 12 panelists who answered that they were not sticky or slimy
15 people. △: 8 to 1 panelists answered that they were not sticky or slimy
1 person. ×: Seven or less panelists answered that they were not sticky or slimy.

(2) Swelling of the skin The test sample was applied by hand to the upper arm of 20 female panelists,
A questionnaire was conducted on the feeling of suppleness of the skin after application, and the following criteria were evaluated. ◎: 16 panelists answered that the skin after application had a swelling
More than a name. ○: 12 panelists answered that the skin after application was supple
~ 15 people. △: 8 to 8 panelists who answered that the skin after application was supple
11 people. X: 7 or less panelists who answered that the skin after application was supple.

(3) Swelling of the skin due to continuous use The test sample was applied by hand to the upper arm of 20 female panelists,
A questionnaire was conducted on the feeling of skin suppleness after continuous use for 30 days, and evaluation was made according to the following criteria. ⊚: 16 or more panelists who responded that their skin had a swelling after continuous use. ◯: 12 to 15 panelists who answered that the skin after continuous use had a swelling. Δ: 8 to 11 panelists who answered that the skin after continuous use had a scalp. X: Seven or less panelists answered that the skin after continuous use had a scalp.

[0014]

[Table 1] ────────────────────────────────── Test Example 1 2 3 4 5 6 6 ──── ────────────────────────────── Ascorbic acid 2-2-2-2-O-D-glucopyranosyl-L-ascorbic acid − 2 − 2 − 2 Collagen 0.0001 0.0001 1 1 25 25 1,3-butylene glycol 5 5 5 5 5 5 Glycerin 5 5 5 5 5 5 Carboxyvinyl polymer 0.5 0.5 0.5 0.5 0.5 0.5 Caustic potassium 0.3 0.3 0.3 0.3 0.3 0.3 EDTA3Na ・3H ₂ O 0.05 0.05 0.05 0.05 0.05 0.05 ────────────────────────────────── Stickiness ◎ ◎ ○ ○ × × Swelling of the skin × × ○ ○ ◎ ◎ ◎ Swelling of the skin with continuous use × ○ △ ◎ ○ ○ ─────────────────────────── ──── ──

As can be seen from Test Examples 1 and 2 in Table 1, when the amount of collagen is small, the stickiness is small,
I didn't feel the elasticity of the skin. On the other hand, as can be seen from Test Examples 5 and 6, when the amount of collagen is large, the feeling of elasticity immediately after application is very good, and the feeling of elasticity of the skin due to continuous use can be felt, but is often sticky.
Usability became very poor. As can be seen from Test Examples 3 and 4, when the content of collagen was proper, there was no stickiness, and the feeling of skin elasticity after application and continued use was very good.
By blending -O-D-glucopyranosyl-L-ascorbic acid, the suppleness of the skin with continuous use became excellent.

Example 1 Emulsion An emulsion was produced by a conventional method according to the following formulation. POE (20) POP (2) Cetyl alcohol ether 1.0% by mass Silicone KF96 (20cs) 2.0     (Shin-Etsu Chemical Co., Ltd.) Liquid paraffin 3.0 Propylene glycol 5.0 Glycerin 2.0 Ethyl alcohol 5.0 Carboxy vinyl polymer 0.3 Hydroxypropyl cellulose 0.1 2-aminomethyl propanol 0.1 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Water-soluble collagen 0.01 Preservative Suitable amount Fragrance suitable amount Distilled water remaining

Example 2 Emulsion An emulsion was produced by a conventional method according to the following formulation. POE (20) POP (2) Cetyl alcohol ether 1.0% by mass Silicone KF96 (20cs) 2.0     (Shin-Etsu Chemical Co., Ltd.) Liquid paraffin 3.0 Propylene glycol 5.0 Glycerin 2.0 Ethyl alcohol 5.0 Carboxy vinyl polymer 0.3 Hydroxypropyl cellulose 0.1 2-aminomethyl propanol 0.1 Vitamin A acid 0.05 2-O-α-D-glucopyranosyl-L-ascorbic acid 2.0 Water-soluble collagen 0.1 Preservative Suitable amount Fragrance suitable amount Distilled water remaining

Example 3 Emulsion An emulsion was produced by a conventional method according to the following formulation. Caustic potash 0.2 mass% Stearic acid 2.0 Cetanol 1.0 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 8.0 Squalane 3.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 0.1 POE (10) Monooleate 2.5 Triethanolamine 1.0 Propylene glycol 5.0 Water-soluble collagen 10.0 Preservative Suitable amount Fragrance suitable amount Distilled water remaining

Example 4 Nutrition cream A nutritional cream was produced by a conventional method according to the following formulation. Stearic acid 2.0 mass% Stearyl alcohol 7.0 Reduced lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 POE (25) cetyl ether 3.0 Glyceryl monostearate 2.0 Preservative Suitable amount Fragrance suitable amount Propylene glycol 5.0 Water-soluble collagen 5.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Citric acid 0.02 Na citrate 0.08 Caustic potash 0.3 BHT 0.03 Edetate 0.05 Distilled water remaining

Example 5 Peel-off type pack A pack was manufactured by a conventional method according to the following formulation. 95% ethanol 10.0 mass% POE (15) oleyl alcohol ether 2.0 Preservative Suitable amount Fragrance suitable amount (Water phase) Allantoin 1.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Polyvinyl alcohol 12.0 Glycerin 3.0 Polyethylene glycol 1500 1.0 Deionized water remaining

Example 6 Emulsion An emulsion was produced by a conventional method according to the following formulation. POE (20) POP (2) Cetyl alcohol ether 1.0% by mass Silicone KF96 (20cs) 2.0     (Shin-Etsu Chemical Co., Ltd.) Liquid paraffin 3.0 Propylene glycol 5.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxy vinyl polymer 0.3 Hydroxypropyl cellulose 0.1 2-aminomethyl propanol 0.1 Water-soluble collagen 15.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Preservative Suitable amount Fragrance suitable amount Citric acid 0.03 Na citrate 0.07 Caustic potash 0.2 BHT 0.01 Trisodium edetate 0.1 Distilled water remaining

Example 7 Astringent lotion Astringent lotion was produced by a conventional method according to the following formulation. Dipropylene glycol 2.0 mass% Citric acid 0.03 Sodium citrate 0.05 2-O-α-D-glucopyranosyl-L-ascorbic acid 0.001 Ethyl alcohol 15.0 Polyoxyethylene (15 mol addition)               Oleyl alcohol ether 0.5 Water-soluble collagen 5.0 Preservative Suitable amount Fragrance suitable amount Distilled water remaining

Example 8 Lotion A lotion was manufactured by a conventional method according to the following formulation. Sorbitol (70%) 3.0% by mass Glycerin 5.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Polyoxyethylene (80 mol addition) hydrogenated castor oil derivative 0.5 Water-soluble collagen 1.0 Decaglycerin diisostearate 0.01 Ethyl alcohol 20.0 Preservative Suitable amount Fragrance suitable amount Distilled water remaining

Example 9 Cream A cream was produced by a conventional method according to the following formulation. Beeswax 10.0% by mass Paraffin wax 6.0 Lanolin 3.0 Isopropyl myristate 6.0 Squalane 8.0 Liquid paraffin 25.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 0.5 Polyoxyethylene sorbitan monostearate 4.2 Propylene glycol 2.0 Borax 0.7 Water-soluble collagen 0.5 Preservative Suitable amount Fragrance suitable amount Distilled water remaining

Example 10 Emulsion A. Vaseline 1.0% by mass Liquid paraffin 2.0 POE (20) oleic acid 1.0 Glycerin monooleate 1.0 Octyl methoxycinnamate 0.05 4-Methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 Preservative 0.2 Perfume 0.1 B. Propylene glycol 1.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Water-soluble collagen 2.0 Hibiswako 105 0.2 Potassium hydroxide 0.4 Trisodium edetate 0.05 2-hydroxy -4-Methoxybenzophenone-5-sulfonate 0.3 Distilled water Remaining amount (manufacturing method) After heating the raw materials of the oil phase part belonging to A and the raw materials of the water phase part belonging to B respectively to 70 ° C. ,
The oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

[0026] Example 11 Emulsion A. Vaseline 1.0 mass% Liquid paraffin 2.0 POE (20) oleic acid 1.0 Glycerin monooleate 1.0 Behenic acid 0.3 Stearic acid 0.5 Isostearic acid 0.4 BHT 0.01 Preservative 0.2 Perfume 0.1 B. Propylene glycol 1.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Water-soluble collagen 3.0 Trisodium edetate 0.05 2-hydroxy-4-methoxybenzophenone                           -5-sulfonate 0.3 Hibisu Wako 105 0.1 Potassium hydroxide 0.05 Distilled water remaining (Production method) Same as in Example 10.

Example 12 Daytime emulsion A. Vaseline 1.0% by mass Tetra-2-ethylhexyl acid pentaerythritol 5.0 Liquid paraffin 2.0 POE (20) oleic acid 1.0 Glycerin monooleate 1.0 Behenic acid 0.7 Stearic acid 0.1 Isostearic acid 0 .2 Octyl methoxycinnamate 5.0 4-Methoxy-4'-t-butyldibenzoylmethane 3.0 2-Hydroxy-4-methoxybenzophenone 0.5 BHT 0.01 Preservative 0.2 Perfume 0.1 B ． Propylene glycol 1.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 1.0 Water-soluble collagen 3.0 Trisodium edetate 0.05 Hibiswako 105 0.2 Potassium hydroxide 0.45 Distilled water residue Amount (manufacturing method) The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B are respectively heated to 70 ° C. and completely dissolved,
The oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 13 Cream A. Cetanol 2.0% by mass Vaseline 2.0 Squalane 20.0 Glycerin monofatty acid ester 2.0 Tween60 3.0 (POE (20) sorbitan monostearate) Isopropyl myristate 6.0 Stearyl glycyrrhetinate 0.5 Glycerin mono- 2-ethylhexanoyl-diparamethoxycinnamate 0.05 4-methoxy-4'-t-butyldibenzoylmethane 0.05 BHT 0.01 preservative 0.3 perfume 0.2 B.I. Glycerin 10.0 Propylene glycol 5.0 2-O-α-D-glucopyranosyl-L-ascorbic acid 5.0 Water-soluble collagen 5.0 Trisodium edetate 0.1 Potassium hydroxide 1.0 Distilled water balance ( Manufacturing method) The raw material of the oil phase portion belonging to A and the raw material of the aqueous phase portion belonging to B are respectively heated to 70 ° C. and completely dissolved,
The oil phase part is mixed with the water phase part and emulsified by an emulsifying machine. The emulsion is cooled with a heat exchanger to a final temperature of 30 ° C.

Example 14 Pack 2-O-α-D-glucopyranosyl-L-ascorbic acid 10.0% by mass 2-hydroxy-4-methoxybenzophenone-5-sulfonate 0.5 BHT 0.01 Polyvinyl alcohol 10 0.0 polyethylene glycol 3.0 propylene glycol 7.0 ethanol 10.0 POE (15) oleyl alcohol ether 0.5 preservative 0.05 water-soluble collagen 8.0 trisodium edetate 0.2 perfume 0.05 distilled water 2-O-α-D-glucopyranosyl-L-ascorbic acid, polyethylene glycol, 2-
Hydroxy-4-methoxybenzophenone-5-sulfonate and a preservative were added and dissolved with stirring. Next, polyvinyl alcohol was added and dissolved by heating, and BHT and POE (15) oleyl alcohol ether were added to propylene glycol and dissolved by heating. Finally, ethanol in which the fragrance was dissolved was added and dissolved by stirring to obtain a pack.

[0030]

The external preparation for skin of the present invention provides skin elasticity and elasticity from the inside and the outside of the skin by combining 2-OD-glucopyranosyl-L-ascorbic acid with collagen or a collagen-degrading protein. Is.

Continued front page    F-term (reference) 4C083 AA082 AB032 AB152 AC022                       AC092 AC102 AC122 AC132                       AC182 AC242 AC302 AC352                       AC422 AC432 AC442 AC472                       AC532 AC542 AD042 AD092                       AD112 AD152 AD282 AD431                       AD432 AD512 AD622 AD641                       AD642

Claims (2)

[Claims] 1. One or more selected from the group consisting of collagen and collagen-degrading protein;
A skin external preparation characterized by being blended with an OD-glucopyranosyl-L-ascorbic acid derivative. 2. The amount of one or more selected from the group consisting of collagen and collagen-degrading protein is 0.001 to 20% by mass as a dry residue, and 2-
The external preparation for skin according to claim 1, wherein the compounding amount of the OD-glucopyranosyl-L-ascorbic acid derivative is 0.0005 to 5.0% by mass.