JP2018172304A - Oil-in-water emulsion composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oil-in-water emulsion composition that contains nicotinic acid amide, improves skin resilience and firmness, has no irritation or stickiness with a good feeling of use, and has high crystal inhibitory effect.SOLUTION: An oil-in-water emulsion composition contains following components (A)- (D): (A) nicotinic acid amide 1-10 mass%, (B) ester of C16-20 linear fatty acid and polyethylene glycol, (C) vaseline 1-10 mass%, and (D) water 70 mass% or less, with the mass ratio (D)/(A) between the contents of component (D) and component (A) being 3 or more.SELECTED DRAWING: None

Description

The present invention relates to an oil-in-water emulsified composition that improves the firmness and elasticity of the skin, has an excellent feeling of use without stickiness, and has an excellent effect of suppressing crystal precipitation.

Skin causes spots, wrinkles, sagging, pigmentation and the like due to internal factors such as aging and stress and external factors such as ultraviolet rays and air drying. Among them, morphological changes such as wrinkles and sagging greatly affect the appearance impression, and many people want to improve it. Many drugs have been proposed to prevent and improve these wrinkles and sagging. Among these, nicotinamide is a vitamin that is high in safety, has an effect of improving rough skin and keratin, and is known to improve the firmness and elasticity of the skin. (Patent Documents 1 and 2) Further, nicotinamide is known to have a whitening effect in addition to the effect of improving rough skin and the effect of improving keratin. (Patent Document 3) However, it has been known that when a large amount of nicotinamide is contained, there is an undesirable feeling of use such as stickiness. (Patent Documents 2 and 4) When using a composition containing more than 1% by mass of nicotinamide, crystals of nicotinamide may precipitate on the skin surface or the side of the container on which the composition hangs down. Have made these improvements. (Patent Document 5)

JP-A-10-130135 JP 2012-041302 A JP 2007-176810 A Special table 2003-502435 gazette Special table 2002-537241 gazette

However, Patent Documents 2 and 4 which try to suppress stickiness have a concern that crystals may precipitate when a large amount of nicotinamide is contained. On the other hand, Patent Document 5 which attempts to suppress crystal precipitation is a technique using a cation-containing polymer, but the stickiness is increased and the feeling of use is poor.

That is, there is no known oil-in-water emulsion composition that contains nicotinamide, improves the firmness and elasticity of the skin, has no stickiness, is excellent in use feeling, and does not precipitate crystals.

In view of this situation, the present inventor has conducted extensive research to solve the above problems, and as a result, oil-in-water emulsification prepared by emulsification using an ester of a linear fatty acid having 16 to 20 carbon atoms and polyethylene glycol. It has been found that stickiness of nicotinamide is suppressed by containing petrolatum in the composition. Moreover, it discovered that crystal | crystallization precipitation was suppressed by making content of water into the range of 70 mass% or less in an oil-in-water-type emulsion composition more than 3 times the amount of nicotinamide.
Surprisingly, by combining these, it was found that the firmness and elasticity of the skin was improved compared to the case of containing nicotinamide alone, and that morphological changes of aging such as wrinkles and sagging were prevented and improved. As a result, the present invention has been completed.

That is, the present invention provides the following components (A) to (D);
(A) Nicotinamide 1 to 10% by mass
(B) Ester of linear fatty acid having 16 to 20 carbon atoms and polyethylene glycol (C) Vaseline 1 to 10% by mass
(D) It relates to an oil-in-water emulsion composition containing 70% by mass or less of water and having a content ratio (D) / (A) of 3 or more of the component (D) and the component (A).

Furthermore, it is related with the oil-in-water type emulsion composition whose content mass ratio (A) / (C) of the said component (A) and the said component (C) is 0.5-5.0.

Furthermore, it is related with the oil-in-water emulsion composition whose average added mole number of the ethylene oxide of the said component (B) is 40-55.

Furthermore, the present invention relates to an oil-in-water emulsion composition that is a cosmetic or a skin external preparation.

The oil-in-water emulsified composition of the present invention improves the firmness and elasticity of the skin, has no stickiness, is excellent in use feeling, and has an excellent crystal precipitation suppressing effect.

Hereinafter, the present invention will be described in detail. In the present specification, “to” means a range including numerical values before and after. Moreover, the numerical value described in% is a value based on mass, unless otherwise specified.

Component (A): Nicotinamide The component (A) nicotinamide in the present invention is an amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is a known substance that is one of the vitamin B groups, and can be extracted from a natural product (rice bran or the like) or synthesized by a known method. Specifically, those listed in the 15th revision Japanese Pharmacopoeia 2008 can be used. Soluble, easily soluble in water and ethanol, and hardly soluble in diethyl ether. Difficult to dissolve in polyhydric alcohols and oils.

The content of the component (A) in the present invention is 1 to 10% by mass (hereinafter simply referred to as “%”). When the content of the component (A) is less than 1%, an effect cannot be obtained in terms of rough skin, improvement of skin firmness and elasticity. On the other hand, if it exceeds 10%, a satisfactory product cannot be obtained in terms of the feeling of use. The content of component (A) is preferably 3 to 8%.

Component (B): ester of linear fatty acid having 16 to 20 carbon atoms and polyethylene glycol Component (B) ester of linear fatty acid having 16 to 20 carbon atoms and polyethylene glycol in the present invention is an ester having 16 to 20 carbon atoms. It is obtained by adding ethylene oxide to a linear fatty acid. In the present invention, specifically, polyethylene glycol dipalmitate (3EO), polyethylene glycol monooleate (14EO), And polyethylene glycol monostearate (40E.O.), polyethylene glycol monostearate (55E.O.), polyethylene glycol distearate (150E.O.), and the like. These may be used singly or in combination. it can. In addition, E.I. O. Represents the average number of moles of ethylene oxide added, and the average number of moles added in the composition of the component (B) is preferably 40 to 55 from the viewpoint of reduction in stickiness.

Examples of commercially available esters of the straight chain fatty acid having 16 to 20 carbon atoms and polyethylene glycol include Nikkor MYS-40V and MYS-55V (manufactured by Nikko Chemicals).

In the present invention, the content of the component (B) is not particularly limited, but is preferably 0.5 to 5%, more preferably 0.8 to 3%. If it is this range, it is excellent also in the stickiness reduction effect and the crystal precipitation inhibitory effect.

Component (C): Vaseline Component (C) Vaseline in the present invention is a semi-solid hydrocarbon mixture obtained from petroleum, and those usually used for cosmetics and pharmaceuticals can be suitably used.

In the present invention, the content of component (C) is 1 to 10%. When the content of the component (C) is less than 1%, an effect cannot be obtained in terms of improving the elasticity and elasticity of the skin, and the stickiness reduction effect is inferior. Moreover, when it contains exceeding 10%, it is inferior to the stickiness reduction effect. The content of component (C) is preferably 3 to 8%.

Component (D): Water Component (D) water in the present invention is contained in order to dissolve component (A) and suppress crystallization, and to form an oil-in-water emulsion composition. If it is generally used, it will not be restrict | limited. In addition to water, purified water, hot spring water, deep water, or plant steam distilled water may be used, and one or two or more kinds may be appropriately selected and used as necessary.

In the present invention, the content of the component (D) is 3 times or more that of the component (A) in order to dissolve the component (A) and suppress crystallization. Moreover, when the ratio of the component (D) in a composition becomes high too much, when a composition is used, the component (D) will volatilize and a composition will concentrate, and the skin surface and the composition which the composition drooped Since crystals of nicotinamide may precipitate on the side surface or the like, the content is 70% or less.

The oil-in-water emulsion composition of the present invention contains the components (A) to (D), thereby improving the elasticity and elasticity of the skin, and preventing and improving morphological changes in aging such as wrinkles and sagging. Thus, it becomes possible to obtain an oil-in-water emulsion composition which is excellent in use feeling without irritation and stickiness and excellent in crystal precipitation suppression effect.

Here, when the mass ratio (A) / (C) of the component (A) and the component (C) in the oil-in-water emulsion composition is 0.5 to 5.0, the skin of the oil-in-water emulsion composition The elasticity and elasticity are improved, and stickiness is particularly reduced.

In the oil-in-water emulsion composition of the present invention, in addition to the above-described components, optional components contained in ordinary cosmetics within a range not impeding the effects of the present invention, that is, oil components other than the aqueous component and component (C) , Powders, water-soluble polymers, film-forming agents, surfactants other than component (B), oil-soluble gelling agents, organically modified clay minerals, resins, colorants, UV absorbers, antiseptics, antibacterial agents, fragrances , Antioxidants, pH adjusters, chelating agents, cosmetic ingredients, and the like.

The oil-in-water emulsion composition of the present invention can be made into various dosage forms by using in combination with other components. Specifically, it can be carried out in various dosage forms such as liquid, gel, paste, cream, and solid.

The oil-in-water emulsion composition of the present invention is suitable for preparation as a cosmetic or an external preparation for skin, particularly as an anti-aging cosmetic or a whitening cosmetic. Examples of cosmetic applications include lotion, milky lotion, cream, beauty serum, massage cosmetics, pack cosmetics, hand creams, body lotions, body creams, makeup cosmetics, cosmetic base cosmetics, eye creams, Suitable as sunscreen, hair cream, hair wax, etc., hand cream is more preferable. The usage method includes a method of using hands, fingers and cotton, a method of impregnating a nonwoven fabric and the like, and the like. Moreover, as a use of a skin external preparation, an external liquid agent, an external gel agent, a cream agent, an ointment, a liniment agent, a lotion agent, a haptic agent, a plaster agent, a spray agent, an aerosol agent etc. are mentioned, for example. Moreover, the usage method can be mentioned similarly to the above-mentioned cosmetics.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto. Unless otherwise specified, the content is expressed in mass% with respect to the system containing the component.

Invention products 1 to 10 and comparative products 1 to 11: Oil-in-water emulsified creams Oil-in-water emulsified creams having the formulations shown in Tables 1 and 2 below are prepared, and the skin elasticity / stickiness, stickiness, and the effect of suppressing crystal precipitation are described below The method was evaluated. The results are also shown in Tables 1-2.

(Evaluation item)
A. Skin firmness and elasticity. No stickiness c. Crystal precipitation suppression effect

(Evaluation method)
[About ii, ro (sensory evaluation)]
Women in their 20s and 40s received sensory evaluation training and selected 10 professional panels that could be evaluated according to certain standards. For each sample, the skin's firmness, elasticity, and stickiness felt when applied to the skin by each panel are rated in the following 5 grades and given a score. For each sample, the average value is calculated from the total score of all the panels. Calculated and judged according to the following four-step criteria.

(I. Evaluation of skin elasticity and elasticity)
Absolute Evaluation Criteria (Score): (Evaluation)
5 points: I feel that the skin is firm and elastic 4 points: I feel that the skin is firm and elastic 3 points: Normal 2 points: I do not feel that the skin is firm and elastic 1 point: Skin is firm・ I don't feel that there is elasticity Four-level criteria (Judgment): (Average score)
◎: More than 4 points: Very good ○: More than 3 points, 4 points or less: Good △: More than 2 points, 3 points or less: Slightly poor ×: 2 points or less: Bad

(B. Evaluation of non-stickiness)
Absolute Evaluation Criteria (Score): (Evaluation)
5 points: No stickiness 4 points: Little stickiness 3 points: Somewhat stickiness 2 points: Feels sticky 1 point: Very sticky 4 criteria (Decision): (Average score)
◎: More than 4 points: Very good ○: More than 3 points, 4 points or less: Good △: More than 2 points, 3 points or less: Slightly poor ×: 2 points or less: Bad

[C. Evaluation of crystal precipitation suppression effect]
For the evaluation of the crystal precipitation inhibiting effect, the sample was applied on a glass plate with a film thickness of 800 μm with a doctor blade, air-dried at 20 ° C. for 15 minutes, and each sample was observed with a microscope. The crystal precipitation state was observed with a polarizing filter at an optical microscope observation of 40 times.
<Criteria>
(Judgment): (Evaluation)
A: No crystal precipitation is observed.
○: Slight crystal precipitation is observed.
X: Crystal precipitation is clearly observed.

(Production method)
A: Components 1 to 7 are uniformly dissolved and mixed at 70 ° C.
B: Components 8 to 18 are uniformly dissolved and mixed at 70 ° C.
C: B is added to A and emulsified at 70 ° C.
D: After 10% of component 2 and components 19-22 were added to C and mixed, the mixture was cooled to 40 ° C. to obtain an oil-in-water emulsified cream.

As is clear from the results of Tables 1 and 2, the oil-in-water emulsified creams of the present invention products 1 to 10 are firmer and more elastic than the oil-in-water emulsified creams of the comparative products 1 to 11, and no stickiness. It was excellent in all of the crystal suppression effects.
On the other hand, Comparative Product 1 with a content of component (A) of less than 1% has poor skin firmness and elasticity, and Comparative Product 2 with a content of component (A) of more than 10% has increased stickiness. It was. In comparative product 3 containing no component (B), an oil-in-water emulsified cream could not be prepared due to poor emulsification and could not be evaluated. Comparative product 4 using esters with different carbon number of fatty acid and average added mole number of ethylene oxide instead of component (B), and comparative product 5 using ether of phytosterol and polyethylene glycol instead of component (B) It was inferior to the product of the present invention in terms of lack. The comparative product 6 in which the content of the component (C) is less than 1% and the comparative product 7 in which the content of the component (C) exceeds 10% were inferior in non-stickiness. In comparative product 8 using hydrogenated polyisobutene composed of the same hydrocarbon instead of (C), the firmness and elasticity of the skin was inferior and stickiness increased. Moreover, in the comparative product 9 using the microcrystalline wax composed of the same hydrocarbon instead of the component (C), the elasticity and elasticity of the skin is inferior, and the crystal of microcrystalline wax is precipitated together with the crystal of nicotinamide. I have. In Comparative Example 10 in which the content of component (D) was less than 3 times the content of component (A), stickiness increased and crystals precipitated. In Comparative Example 11 in which component (D) was contained in an oil-in-water emulsion emulsion by 70% or more, crystals were precipitated.

Example 2: Oil-in-water emulsion (component) (%)
1.1,3-Butylene glycol 12.0
2. Glycerin 5.0
3. Purified water 59.56
4). Nicotinamide 6.0
5. Polyethylene glycol monostearate (40 EO) 0.5
6). Sorbitan sesquioleate 0.1
7). Hydrogenated lecithin 0.1
8). Cholesteryl hydroxystearate (Note 4) 3.0
9. Vaseline 2.0
10. α-olefin oligomer 5.0
11. Shea Butter 2.0
12 Dimethylpolysiloxane (10CS) 1.0
13. Ceramide 3 0.1
14 Astaxanthin 0.1
15. Tocopherol 0.01
16. Cetostearyl alcohol 2.0
17. Behenyl alcohol 1.0
18. Methyl paraoxybenzoate 0.1
19. Acrylic acid / alkyl methacrylate copolymer (Note 5) 0.1
20. Xanthan gum 0.1
21. Sodium hydroxide 0.03
22. Fragrance 0.2
Note 4) Saracos HS (Nisshin Oilio Co., Ltd.)
Note 5) Carbopol ULTREZ21 (manufactured by LUBRIZOL)

(Production method)
A: Components 1 to 4 are uniformly dissolved and mixed at 70 ° C.
B: Components 5 to 17 are uniformly dissolved and mixed at 80 ° C.
C: B is added to A and emulsified at 70 ° C.
D: After 10% of component 3 and components 18 to 22 were added to C and mixed, the mixture was cooled to 40 ° C. to obtain an oil-in-water emulsion.

The oil-in-water emulsified emulsion of Example 2 was excellent in all of the firmness / elasticity of the skin, stickiness, and crystal precipitation suppression effect.

Example 3: Oil-in-water emulsified beauty serum (component) (%)
1.1,3-Butylene glycol 5.0
2. Dipropylene glycol 5.0
3. Tripropylene glycol 3.0
4). Purified water 69.29
5. Nicotinamide 4.0
6). Monooleic acid polyoxyethylene sorbitan (20E.O.) 0.1
7). Polyethylene glycol monostearate (55EO) 0.25
8). Macadamia nut oil fatty acid phytosteryl (Note 6) 2.0
9. Light liquid isoparaffin (Note 7) 3.0
10. Dimethylpolysiloxane (6CS) 3.0
11. Cholesterol 0.1
12 Tocopherol 0.01
13. Cetostearyl alcohol 0.5
14 Methyl paraoxybenzoate 0.1
15. Carbomer (Note 3) 0.15
16. (Na-acrylate / acryloyldimethyltaurine Na) copolymer (Note 8) 0.1
17. Sodium hydroxide 0.05
18. Ethanol 5.0
19. Collagen 0.1
20. Elastin 0.1
21. Hyaluronic acid 0.1
22. Fragrance 0.05
Note 6) PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.)
Note 7) Chloratum LES (manufactured by Croda)
Note 8) SIMULGEL EG (manufactured by SEPIC)

(Production method)
A: Components 1 to 4 are uniformly dissolved and mixed at 70 ° C.
B: Components 5 to 12 are uniformly dissolved and mixed at 80 ° C.
C: B is added to A and emulsified at 70 ° C.
D: After 10% of component 4 and components 13 to 17 were added to C and mixed, the mixture was cooled to 40 ° C. to obtain an oil-in-water emulsified beauty serum.

The oil-in-water emulsified beauty liquid of Example 3 was excellent in all of the firmness and elasticity of the skin, stickiness, and the effect of suppressing crystal precipitation.

The present invention can be applied to cosmetics, quasi drugs, external preparations for skin, and the like.

Claims (4)

The following components (A) to (D);
(A) Nicotinamide 1 to 10% by mass
(B) Ester of linear fatty acid having 16 to 20 carbon atoms and polyethylene glycol (C) Vaseline 1 to 10% by mass
(D) An oil-in-water emulsion composition containing 70% by mass or less of water and having a content mass ratio (D) / (A) of 3 or more of the component (D) and the component (A). 2. The oil-in-water emulsion composition according to claim 1, wherein the content ratio (A) / (C) of the component (A) and the component (C) is 0.5 to 5.0. The oil-in-water emulsion composition according to claim 1 or 2, wherein the average added mole number of ethylene oxide of component (B) is 40 to 55. The oil-in-water emulsion composition according to any one of claims 1 to 3, which is a cosmetic or an external preparation for skin.