TW202128125A - External preparation for skin - Google Patents

Abstract

The present invention addresses the problem of obtaining a composition that contains niacinamide and is not sticky, provides an excellent feeling of penetration, and also gives an excellent feeling of firmness after use. The external preparation for skin that solves this problem is an external preparation for skin that contains the following components (A)-(D): (A) 1-10 mass% niacinamide, (B) a cationic surfactant, (C) an anionic polymer, and (D) water.

Description

Skin topical agent

The present invention relates to an external preparation for skin containing nicotine amide, and more specifically, it relates to an external preparation for skin containing a cationic surfactant and an anionic polymer with excellent stability.

Skin can cause spots, wrinkles, sagging or pigmentation due to internal factors such as aging or stress, or external factors such as ultraviolet rays or dry air. Among them, morphological changes such as wrinkles and sagging greatly affect the appearance impression, and many people expect improvement. In order to prevent and improve such wrinkles and sagging, various active ingredients have been proposed; among them, nicotine amide is known to be highly safe and has anti-aging effects on the skin (for example, refer to Patent Documents 1 and 2). However, when a large amount of nicotine amide is contained, it is known that there is an undesirable feeling in use, such as a strong stickiness, and some people have improved it (for example, refer to Patent Document 3).

In addition, for cosmetics or external skin preparations used for topical application to the skin and hair, some people have devoted themselves to research and development to improve the penetration of active ingredients into tissues. As one of the means, the use of electric charges in the composition can be mentioned. Salty recognizes that the surface of the skin is negatively charged, and positively charged cationic substances are known to have higher absorption or permeability to the skin. Therefore, in order to improve the adsorption and permeability of the active ingredients to the biological tissues, cosmetics containing cationized polymers have been provided (for example, refer to Patent Documents 4 and 5). However, when an anionic substance is used in combination, since a complex is formed in the composition, there are problems such as cloudiness, aggregation or agglomeration. In addition, as another means for enhancing the permeability of the active ingredient, the use of vesicle particles can be cited, and a vesicle composition containing a cationic surfactant combining these two means is also known (for example, refer to Patent Document 6) . [Prior Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. 10-130135 [Patent Document 2] Japanese Patent Laid-Open No. 10-001414 [Patent Document 3] Japanese Special Publication No. 2003-502435 [Patent Document 4] JP 2016-108344 A [Patent Document 5] International Publication No. 2019/111415 Handbook [Patent Document 6] International Publication No. 2014/069631 Handbook

[The problem to be solved by the invention]

Therefore, in the present invention, a cationic surfactant with excellent skin permeability has been developed, but it can inhibit and alleviate the agglomerates generated by the electrical interaction and has good stability, and can interact with various anions. The technology of combined use of sexual substances is the subject. In addition, the present invention is to provide a large amount of nicotine amide blended as an effective ingredient, which does not have a sticky feeling when used, has excellent permeability to the skin, and has a firmness and firmness of the skin after application. It is also an excellent external preparation for the skin. [Means to solve the problem]

Therefore, the inventors of the present case have worked hard to solve the above-mentioned problems. As a result, they have found that in a composition containing a cationic surfactant and an anionic polymer, the use of nicotine amide can alleviate the cationic surfactant. Condensation caused by electrical interaction with anionic polymers completes the present invention.

That is, the present invention provides an external preparation for skin, which contains the following components (A) to (D): (A) Nicotinamide 1-10% by mass, (B) Cationic surfactant, (C) Anionic polymer, (D) Water. [Effects of Invention]

According to the present invention, by using nicotine amide together, the generation of precipitates caused by the electrical interaction between the cationic surfactant and the anionic polymer can be suppressed. In addition, the external preparation for skin of the present invention has no sticky feeling when used, has excellent penetration into the skin, and has excellent makeup effects such as firmness of the skin after application. In addition, the external preparation for skin can be used for a long time due to its excellent stability. Therefore, it can be used as a cosmetic that can improve skin elasticity, prevent or improve wrinkles, sagging skin, and other aging morphological changes. .

[The form of implementing the invention]

The present invention will be described in detail below. In addition, in this specification, "~" refers to the range including the numerical value before and after it. The component (A) nicotine amide used in the present invention is a niacin compound of nicotinic acid (vitamin B3/nicotinic acid). Nicotinamide is a water-soluble vitamin. It is a well-known substance belonging to the vitamin B group. It can be extracted from natural products (rice bran, etc.) or synthesized by well-known methods. Specifically, those described in the 17th revised Japanese Pharmacopoeia can be used.

The content of the component (A) in the present invention is 1-10% by mass (hereinafter, "mass%" is abbreviated as "%"), preferably 3-10%, particularly preferably 4-9%. If the content of component (A) is less than 1%, firmness and the like cannot be obtained; and when it exceeds 10%, the stickiness during application is stronger and the feeling in use is poor.

The component (B) cationic surfactant used in the present invention is used to enhance the absorption to the skin, as well as the penetration and skin affinity as an external agent for skin, as long as it is used in general cosmetics or external skin agents, etc. The middle user is not particularly limited, and any one can be used. Component (B) is amine salts such as alkyl amine salts, polyamines and amino alcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridinium salts, imidazolium salts, etc., for example, chlorine Cetyl trimethyl ammonium bromide, cetyl trimethyl ammonium bromide, octadecyl trimethyl ammonium chloride, octadecyl trimethyl ammonium bromide, behenyl trimethyl ammonium chloride, behenyl trimethyl ammonium bromide, methyl Behenyl trimethyl ammonium sulfate, di(octadecyl) dimethyl ammonium chloride, dioleyl dimethyl ammonium bromide, hexadecyl behenyl dimethyl ammonium methyl sulfate, octadecyl two chloride Methylbenzylammonium, dipalmitin ethyl hydroxyethyl methyl ammonium methyl sulfate, dicoconut oil ethyl hydroxyethyl methyl ammonium methyl sulfate, distearyl ethyl hydroxyethyl methyl sulfate Quaternary ammonium salts such as ammonium methyl sulfate can be selected from one or two or more of these.

In addition, as for the component (B) of the present invention, as long as it is cationic in the composition, it may also be the skeleton of an amphoteric surfactant. As such a surfactant, one having an amino acid residue is preferred, and it is preferred that the amino acid residue is a basic amino acid residue. Specifically, stearinyl lysine butyl ester·hydrochloride, N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate, lauryl-ornithine acid Mono-N-long-chain acyl basic amino acid lower alkyl ester salts such as propyl esters and anhydrides; decyl guanidine acid salt, 2-guanidinoethyl lauryl amide hydrochloride, 2-guanidino Guanidine derivatives such as butylstearylamine, DL-pyrrolidone carboxylate, etc. can be selected from one or more of them. In addition, examples of these salts include halogen, methyl sulfate, ethyl sulfate, and methyl phosphate.

Among them, from the viewpoint of stability, quaternary ammonium salts and mono-N-long-chain acyl basic amino acid lower alkyl ester salts are preferred; among the quaternary ammonium salts, alkyltrimethyl chloride is preferred. Ammonium, di-long-chain acyl alkylhydroxyalkyl ammonium; mono-N-long-chain acyl basic amino acid lower alkyl ester salt, preferably N-cocoyl-L-arginine ethyl Base ester pyrrolidone carboxylate. More specifically, a mixture with other aqueous components can be used, and as such a commercially available product, GENAMIN KDMP (manufactured by Clariant Japan Co., Ltd.; pure weight 81.5%) which is a mixture of behenyltrimethylammonium chloride can be mentioned. , DEHYQUART L80 T (manufactured by BASF: 80% pure), a mixture of two coconut oil ethyl hydroxyethyl methyl ammonium methyl sulfate, two palm oil ethyl hydroxyethyl methyl ammonium methyl sulfate The mixture of DEHYQUART AU56/G, DEHYQUART C4046 (all made by BASF), N-cocoyl-L-arginine ethyl ester pyrrolidone carboxylate CAE (made by Ajinomoto), etc. Among them, especially if it is a double-chain type surfactant such as a two-long chain alkylalkylhydroxyalkylammonium, it can form vesicle particles by itself to further improve skin permeability, and it is also preferable that it has excellent stability over time.

The content of the component (B) in the present invention, based on the skin permeability or safety viewpoint, is preferably about 0.001 to 0.1%, more preferably 0.002 to 0.05%, particularly preferably 0.02 to 0.05%.

In the present invention, the content mass ratio (A)/(B) of the component (A) to the component (B) is not particularly limited. From the viewpoint of usability as an external preparation for skin, it is 10 to 500, preferably 25 to 300 , More preferably 25~200. If it is within this range, there is no sticky feeling during use, and a good feeling of penetration or firmness of the skin after application can be felt.

The anionic polymer of the component (C) used in the present invention is an anionic polymer, and it is not particularly limited as long as it is generally used as cosmetics. Specifically, water-soluble polymers such as alginic acid, hyaluronic acid, gum arabic, carrageenan, chondroitin sulfate, gelatin, carboxymethyl cellulose, carboxyvinyl polymer, polyacrylic acid, and their derivatives can be cited , One or two or more of these can be used. In addition, these may vary depending on natural or synthetic sources, and are not particularly limited.

Among them, in the present invention, the carboxyvinyl polymer and/or the alkyl-modified carboxyvinyl polymer are preferred from the viewpoints of no stickiness during use and excellent firmness of the skin after application. The term "carboxyvinyl polymer" as used herein refers to a general term for polymers containing polymerizable monomers having at least a polymerizable vinyl group and a carboxyl group or an alkyl-modified carboxyl group as constituent units. The term "alkyl modification" as used herein refers to those in which part or all of the carboxyl groups are esterified with alkyl. For example, polymers containing at least one acrylate or methacrylate as constituent monomers are contained in the Examples of modified carboxyvinyl polymers. The carbon number of the alkyl-modified alkyl group is not limited, and is preferably 10 or more and 30 or less, and more preferably 18 or more and 24 or less. Commercial products of alkyl-modified carboxyvinyl polymers include CARBOPOL1342, CARBOPOL1382 (the above are manufactured by LUBRIZOL ADVANNCED MATERIALS), Pemulen TR-1, Pemulen TR-2 (the above are manufactured by NOVEON), etc.; carboxyvinyl polymers Commercial products include CARBOPOL940, CARBOPOL941, CARBOPOL980, CARBOPOL934 (the above are manufactured by LUBRIZOL ADVANNCED MATERIALS), AQUPEC HV-501 (manufactured by Sumitomo Seiki), and the like.

The blending amount of component (C) in the present invention is not particularly limited as long as it is a blending amount generally used in cosmetics. Based on the viewpoint of the interaction with component (B), it is preferably 0.001 to 10%. It is preferably 0.01 to 5%, more preferably 0.05 to 1%, particularly preferably 0.05 to 0.2%. If it is within this range, it is possible to provide an external preparation for skin with excellent stability, no stickiness during use, and excellent firmness of the skin after application.

In the present invention, the content mass ratio (A)/(C) of the component (A) to the component (C) is not particularly limited, and is 5.0 to 150, preferably 5.0 to 125, and more preferably 10 to 100. If it is within this range, there will be no stickiness, and the skin's firmness after application will be better. In addition, the content mass ratio (B)/(C) of the component (B) and the component (C) is not particularly limited, but is preferably 0.01 to 10, more preferably 0.05 to 5, and still more preferably 0.1 to 1, especially preferred It is 0.2~0.6. Within this range, the aggregation suppression effect is more excellent.

The component (D) water used in the present invention is not particularly limited as long as it is generally used for cosmetics and the like. In addition to pure water, deep water, or steam distilled water from plants such as rose water or lavender water can also be used within a range that does not impair the effects of the present invention. One or two or more of them can be appropriately selected for use according to requirements. In addition, the blending amount of the component (D) in the present invention is not particularly limited as long as it is a blending amount generally used for cosmetics, and it is preferably 30 to 95%.

Furthermore, in the present invention, if a hydrophilic nonionic surfactant is used for the component (E), the aggregation of the component (B) and the component (C) can be suppressed. As component (E), it is a nonionic surfactant of HLB10-18, more preferably HLB11-16. In addition, the HLB (Hydrophile-Lypophile Balance) value used in the present invention is a value obtained according to the Griffin method. Specifically, polyglycerol fatty acid esters, sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene glycol fatty acid esters, polyoxyethylene two Alcohol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene hardened castor oil, polyoxyethylene fatty acid glycolamide, polyoxyethylene cholesterol ether, polyoxyethylene dihydrocholesterol ether , Polyoxyethylene phytostanol ether, polyoxyethylene phytostanol ether, polyoxyethylene alkyl ether, propylene glycol fatty acid ester, polyoxyalkylene modified polysiloxane, polyoxyethylene phytostanol ether Alkyl alkyl co-modified polysiloxane, etc., one kind or two or more kinds of these can be used. Among them, a nonionic surfactant having a polyoxyethylene group is preferable, and a nonionic surfactant having an average addition molar number of ethylene oxide of 5-100 is preferable, and 10-80 is more preferable.

Component (E) can use commercially available products, such as RHEODOL TW-O120V (manufactured by Kao Corporation), Nonion OT-221 (manufactured by NOF Corporation), monooleic acid polyoxyethylene sorbitan (20E.O.) RHEODOL TW-S120V (manufactured by Kao Corporation), Nonion ST-221 (manufactured by NOF Corporation), polyoxyethylene polyoxypropylene decyl tetradecyl ether ( 20E.O.) of NIKKOL PEN-4620 (manufactured by Nikko Chemicals), EMALEX PS-30 (manufactured by NIHON EMULSION), NIKKOL BPS-30 (manufactured by Nikko Chemicals), polyoxyethylene hardened castor oil (60E.O. ) Of EMALEX HC-60 (manufactured by NIHON EMULSION), NIKKOL HCO-60 (manufactured by Nikko Chemicals), polyoxyalkylene modified organopolysiloxane, such as KF-6011, KF-6011P, KF-6018 , KF-6043 (all manufactured by Shin-Etsu Chemical Co., Ltd.), NUC Silicone SS-2802 (manufactured by Dow Corning Toray Co., Ltd.), etc.

The content of the component (E) in the present invention is not particularly limited, and is preferably 0.01-10%, more preferably 0.05-8%, still more preferably 0.1-6%, particularly preferably 0.5-6%. Within this range, the aggregation of the component (B) and the component (C) can be further suppressed, and a skin external preparation that is stable for a long period of time can be obtained.

In the present invention, the ratio (E)/[(B)+(C)] of component (E) to the total content of component (B) and component (C) is not particularly limited, and is based on component (B) and component (C) The agglomeration inhibitory effect, no sticky feeling or good penetrating feeling during use, is 0.1 to 150, preferably 0.5 to 100, and more preferably 1.0 to 80.

Furthermore, in the present invention, the vesicle particles are formed by the component (B), which can improve the adsorption of electric charge and the permeability as an external preparation for skin, and can further exert the component (A) and other effects synergistically. The effect of the ingredients. As mentioned above, if the surfactant of component (B) is of double-stranded type, it can form vesicles alone, or be combined with other vesicle membranes such as phospholipids or bis(laurylamine glutamate) sodium lysine Component and component (B) can also form vesicle particles containing a cationic surfactant. Among these, phospholipids can be preferably used from the viewpoint of safety. In addition, the method of forming vesicle particles is not particularly limited, and can be produced according to conventional methods; the method of confirming vesicle particles can be performed using a polarizing microscope based on the presence or absence of Maltese cross images under cross-polarized light. When phospholipids are used, the content of phospholipids is not particularly limited, and is preferably 0.01 to 5%, more preferably 0.05 to 1%, and particularly preferably 0.1 to 0.5%.

In addition, the pH of the external preparation for skin of the present invention is not particularly limited, and the pH at 25°C is preferably in the range of 4.0 to 7.5.

In addition to the above-mentioned components (A) to (E), the external preparation for skin of the present invention may suitably contain components generally used for external preparations for skin within a range that does not impair the effects of the present invention. For example, it may contain higher alcohols, hydrocarbon oils, ester oils, waxes, silicone oils and other oils, surfactants, water-soluble polymers, polyols, lower alcohols and other water-based components, ultraviolet absorbers, antioxidants, antibacterial Agents, preservatives, moisturizers, pH adjusters, cooling agents, powders, vitamins, beauty ingredients, fragrances, etc. For example, the preferred composition of the external preparation for skin of the present invention is shown as follows: Composition better (A) 1~10% 3~10% 4~9% 4~9% (B) 0.001~0.1% 0.002~0.05% 0.02~0.05% 0.02~0.05% (C) 0.001~10% 0.01~5% 0.05~1% 0.05~0.2% (D) 30~95% 30~95% 30~95% 30~95% (E) 0.01~10% 0.05~8% 0.1~6% 0.5~6%

The method for producing the external preparation for skin of the present invention is not particularly limited, and can be prepared by a common method. For example, after heating and dissolving the component (B) and other components as required, the components (A), (C) to (E) that are uniformly dissolved and mixed are added and mixed, and then any of the above-mentioned components as required, And it is a method of mixing and modulating.

The external preparation for skin of the present invention can be implemented in various forms such as liquid, gel, cream, etc., and the dosage forms are dissolved, oil in water, water in oil, oily, oil in water, water in oil, and water in oil. Oil type, multilayer type, etc. are not particularly limited. From the standpoint of stability, it is better to feel the effects of the present invention in a low viscosity or translucent state.

In addition, the external preparation for skin of the present invention can be used as cosmetics for skin. Examples include lotions, lotions, creams, beauty liquids, massage materials, facial masks, hand creams, body lotions, and body creams. , Sunscreen, foundation, eye shadow, eyeliner, concealer, scalp treatment, etc. It is better to use skin care cosmetics in terms of being able to feel its effects personally. The method of use can include the method of using hands, fingers or cotton pads, the method of impregnating non-woven fabrics, etc., and the method of direct spraying. Wait. In the preferred aspect of the external skin preparation of the present invention, hair cosmetics dedicated to hair, such as shampoo, conditioner, conditioner, wax, etc., can be excluded. [Example]

Hereinafter, in order to specifically describe the present invention, examples are given, but the present invention is not limited to these examples and the like. In addition, unless otherwise specified, the content is expressed in% by mass relative to the composition containing the component.

Examples 1 to 11 and comparative examples 1 to 4: beauty lotion The beauty serum of the composition shown in Table 1 was produced according to the following manufacturing method, and A: aggregation inhibition effect, B: penetration, C: stickiness, D: skin firmness after application, according to the following Method for evaluation and judgment. The results are shown in Table 1.

(Production method) A: The components (1), (2), (5) to (11), and (16) are uniformly heated and dissolved at 75°C. B: The components (3), (4), (12) to (15) are uniformly heated and dissolved at 75°C. C: A was added to B at 75°C and stirred to obtain a beauty lotion.

(Assessment method 1) (A. Aggregation suppression effect) The aggregation inhibitory effect was evaluated by the transparency when the beauty liquids of Examples 1 to 11 and Comparative Examples 1 to 4 were diluted 10 times with water. It has been confirmed that this transparency can ensure long-term stability. Each of 1.0 g of the composition was measured in a glass beaker, diluted 10 times with pure water, and stirred until a uniform solution was obtained. At this time, a metal ointment spatula was used to mix and stir by hand. The obtained sample was filled in a glass sample cell having an optical path length of 10 mm × an optical path width of 5 mm, and the transmittance at a wavelength of 700 nm was measured with a spectrophotometer (manufactured by UV-2500PC SHIMADZU). <Judgment Criteria> (Judgment): (Assessment) ◎: The penetration rate is more than 55% (after 1 month storage at room temperature, there is no aggregation or precipitation) △: The penetration rate is 45~55% (after one month of storage at room temperature, agglomeration, precipitation, and turbidity changes can be seen approximately) ×: The penetration rate is less than 45% (after one month of storage at room temperature, changes in aggregation, precipitation, and turbidity can be seen)

(Assessment method 2) Women in their 20s to 40s receive sensory assessment training, and 10 professional sensory inspectors who can perform assessments based on established standards are selected. Ask the professional sensory inspector to use each sample on the front wrist, and for each individual, evaluate the penetration, stickiness, and firmness of the skin after application according to the following absolute evaluation according to 5 levels And score. For each sample, the average value was calculated from the scores of all the sensory inspectors, and judged according to the following four-level judgment criteria.

(B: Permeability) ＜Absolute evaluation standard＞ (Rating): (rating) 5 points: I feel that the lotion penetrates the skin 4 points: Slightly feel the penetration of the lotion into the skin 3 points: normal 2 points: There is almost no permeation of the lotion into the skin 1 point: No feeling of penetration of the lotion into the skin ＜4 grade judgment standard＞ (The same applies to the following assessment items) (Judgment): (Average score of scoring) ◎: 4.5 points or more 　　　　　　: extremely good ○: 3.5 points or more and less than 4.5 points: good △: 1.5 points or more and less than 3.5 points: slightly bad ×: less than 1.5 points 　　　　　　: bad

(C: Does it feel sticky) ＜Absolute evaluation standard＞ (Rating): (rating) 5 points: no stickiness 4 points: almost no stickiness 3 points: slightly sticky 2 points: sticky 1 point: extremely sticky

(D: Skin firmness after application) ＜Absolute evaluation standard＞ (Rating): (rating) 5 points: I feel the firmness of the skin 4 points: I feel a little firmness of the skin 3 points: normal 2 points: There is almost no skin firmness 1 point: No skin firmness is felt

From the results in Table 1, it can be seen that the beauty serums of Examples 1 to 11 have better aggregation inhibition effect, penetration, no stickiness, and firmness of the skin after application compared to the beauty serums of Comparative Examples 1 to 4 . On the other hand, in Comparative Example 1, which does not contain the component (A), the skin feels less firm after application. In Comparative Example 2 in which ingredient (A) was changed to another skin-beneficial agent (dipotassium glycyrrhizinate), the aggregation inhibitory effect, no stickiness, and skin firmness after application were poor. Comparative Example 3 with a 0.5% ingredient (A) also failed to feel the firmness of the skin after application, while Comparative Example 4 with a 15% ingredient (A) had too much nicotine amide, which made it difficult to feel the penetrating sensation. , And produced a sticky feeling.

Example 12: Toner (Element) (%) (1) Alkyl trimethylammonium chloride (Note 2) 0.1 (2) Hydrogenated soybean phospholipids (Note 7) 0.5 (3) 1,3-Butanediol 5.0 (4) Monooleic acid polyoxyethylene sorbitan anhydride (20E.O.) 1.0 (5) Perfume in proper amount (6) Ethanol 10.0 (7) Preservatives Appropriate amount (8) Nicotine amine 5.0 (9) Chuanming acid 2.0 (10) Polyoxyethylene glycerin (26E.O.) 2.0 (11) Polyoxyethylene methyl glucoside (Note 8) 2.0 (12) (Acrylate/alkyl acrylate (C10-C30)) crosslinked copolymer (Note 3) 0.1 (13) Carboxy vinyl polymer 0.1 (14) Sodium hydroxide 0.05 (15) Pure water balance (Note 8) Macbiobride MG-10E (manufactured by NOF Corporation)

(Production method) A: The components (1) to (3) are uniformly dissolved and mixed at 75°C. B: While maintaining the aforementioned A at 75°C, a part of the component (15) was added and stirred with a Disper mixer to obtain a vesicle dispersion. C: The components (4) to (15) are uniformly dissolved and mixed at room temperature. D: The aforementioned B cooled to 35°C is added and mixed to the aforementioned C to obtain a lotion. The lotion obtained above has excellent aggregation inhibition effect, penetrating feel, non-sticky feel, and excellent firmness of the skin after application.

Example 13: Transparent lotion (Element) (%) (1) Isostearic acid polyoxyethylene (50) Hardened castor oil 0.2 (2) PEG-10 methyl ether polydimethylsiloxane (Note 4) 0.1 (3) Two coconut oil ethyl hydroxyethyl methyl ammonium methyl sulfate 0.01 (4) Alkyl trimethylammonium chloride 0.01 (5) Ethyl oleate 0.05 (6) hexadecyl 2-ethylhexanoate 0.05 (7) Perfume in proper amount (8) Ethanol 1.0 (9) 1,3-Butanediol 5.0 (10) Glycerin 5.0 (11) Diglycerol 2.0 (12) Polyoxybutylene polyoxyethylene polyoxypropylene glycerol ether (3E.O.) (Note 9) 3.0 (13) Nicotine amine 5.0 (14) Carboxy vinyl polymer 0.1 (15) Sodium hydroxide 0.05 (16) Chuanming acid 1.0 (17) Sodium hydroxide 0.05 (18) Preservatives Appropriate amount (19) Perfume in proper amount (20) Pure water balance (Note 9) WILBRIDE S-753D (manufactured by NOF Corporation)

(Production method) A: The components (1) to (10) are uniformly dissolved and mixed at 70°C. B: The components (11) to (20) are uniformly dissolved and mixed at room temperature. C: The aforementioned A is added to B, and it is melted at room temperature to obtain a transparent lotion. The transparent lotion obtained above has excellent aggregation inhibition effect, penetrating feel, non-sticky feel, and excellent firmness of the skin after application.

Example 14: Oil-in-water emulsified beauty liquid (Element) (%) (1) Polyglycerol-10 (eicosandioic acid/tetradecanedioic acid) ester 1.5 (2) Tripropylene glycol 15.0 (3) Nicotine amine 6.0 (4) L-theanine acid 0.05 (5) 1,3-Butanediol 3.5 (6) Dipropylene glycol 0.5 (7) Pure water balance (8) Glycerin 2.0 (9) Polyethylene glycol 2.0 (10) Chuanming acid 2.0 (11) Sodium hydrogen phosphate 0.3 (12) Sodium dihydrogen phosphate 0.6 (13) Disodium ethylenediaminetetraacetic acid 0.02 (14) Methyl paraben 0.1 (15) Isostearic acid polyoxyethylene (50) Hardened castor oil 0.2 (16) Polyoxyethylene (60) Hardened castor oil 0.2 (17) Two coconut oil ethyl hydroxyethyl methyl ammonium methyl sulfate 0.01 (18) Ethanol 5.0 (19) L-menthol 0.02 (20) Isopropyl myristate 0.3 (21) Dimer two linoleic acid (phytosterol ester/isooctadecyl ester/hexadecyl ester/octadecyl ester/docosyl ester (Note 10) 0.2 (22) Sorbitan oleate 0.2 (23) Tocotrienols 0.02 (24) Carboxy vinyl polymer 0.02 (25) (Acrylic/alkyl acrylate (C10-30)) Cross-linked copolymer (Note 3) 0.02 (26) Xanthan gum 0.01 (27) Sodium hydroxide 0.01 (28) Hydrolyzed hyaluronic acid 0.01 (Note 10) PLANDOOL-S (manufactured by Nippon Seika Co., Ltd.)

(Production method) A: The components (1) to (14) are uniformly mixed at room temperature. B: The components (15) to (23) are uniformly dissolved and mixed at 70°C. C: B is added to the aforementioned A and emulsified at 70°C. D: After cooling the aforementioned C to 40°C, the components (24) to (28) are added and uniformly mixed to obtain a beauty lotion. The oil-in-water emulsified beauty lotion obtained above has an anti-aggregation effect, a penetrating feel, a non-sticky feel, and an excellent firmness of the skin after application.

Example 15: Sunscreen (oil-in-water type) (Element) (%) (1) 1,3-Butanediol 5.0 (2) Dipropylene glycol 5.0 (3)Behenyl trimethylammonium chloride 0.1 (4) Hydrogenated lecithin (Note 11) 0.5 (5) Cholesterol (Note 12) 0.6 (6) Plant sterols 0.1 (7) Pure water balance (8) Nicotine amine 3.0 (9) Chuanming acid 2.0 (10) (Acrylic acid/alkyl acrylate (C10-30)) copolymer (Note 13) 0.4 (11) Triethanolamine 0.4 (12) Polysiloxane-15 1.2 (13) 4-tertiary butyl-4'-methoxy-dibenzyl methane 2.0 (14) 2-ethylhexyl p-methoxycinnamic acid 7.0 (15) Diethylamino hydroxybenzyl hexyl benzoate 2.5 (16) Stearic acid hardened castor oil (Note 14) 1.0 (17) Propylene glycol dicaprate 5.0 (18) Ethyl oleate 0.3 (19) Natural Vitamin E 0.1 (20) Rosemary oil 0.01 (21) 1,2-pentanediol 0.1 (22) Zinc oxide 2.0 (23) Water-soluble collagen 0.01 (24) German chamomile flower extract 0.05 (25) Marigold extracts 0.05 (26) Glycerin 1.0 (27) Ethanol 7.0 (28) Spices 0.1 (Note 11) NIKKOL RETINOL S-10 (manufactured by Nikko Chemicals) (Note 12) Haili Marine Cholesterol (manufactured by Japan Fisheries Corporation) (Note 13) Pemulen TR-2 (manufactured by NOVEON) (Note 14) Castride MS (manufactured by National Mimatsu)

(Production method) A: The components (1) to (6) are uniformly dissolved and mixed at 75°C. B: The components (7) to (11) are uniformly dissolved and mixed at 70°C. C: The components (12) to (19) are uniformly dissolved and mixed at 80°C. D: B and C are added to the aforementioned A and emulsified at 70°C. E: After adding the mixing components (20) to (28) to the aforementioned D, it is cooled to 40°C to obtain a sunscreen (oil-in-water type). The sunscreen (oil-in-water type) obtained above has an anti-aggregation effect, a penetrating feel, a non-sticky feel, and an excellent firmness of the skin after application.

Example 16: Oil-in-water emulsion (Element) (%) (1) 1,3-Butanediol 5.0 (2) Dipropylene glycol 5.0 (3) Alkyl trimethylammonium chloride (Note 2) 0.03 (4) Hydrogenated soybean phospholipids (Note 7) 0.2 (5) Cholesterol (Note 12) 0.7 (6) Pure water balance (7) Nicotine amine 8.0 (8) Sodium hydroxide 2% aqueous solution 0.2 (9) N-nutmegyl-L-glutamic acid 0.2 (10) Polyoxyethylene (10) Hardened castor oil 0.2 (11) Macadamia oil fatty acid plant sterol esters (Note 15) 1.0 (12) Three (caprylic acid/caprylic acid) glycerides 0.2 (13) Tocopherol nicotinic acid ester 0.01 (14) Natural Vitamin E 0.1 (15) Rice germ oil 0.01 (16) Tocopherol acetate 0.01 (17) Monooleic acid polyoxyethylene sorbitan (20E.O.) 1.5 (18) Stearyl alcohol 0.5 (19) Twentydiol 1.0 (20) 1,2-pentanediol 0.1 (21) Stearyl alcohol 0.5 (22) Carboxy vinyl polymer 0.2 (23) (Sodium Acrylate/Sodium Acrylate Dimethyl Taurate) Copolymer (Note 16) 0.5 (24) Chuan Ming acid 1.0 (25) Diglycerol 0.5 (26) Yemen grass extract 0.05 (27) Algae extracts 0.05 (28) Black soybean extract 0.05 (29) Sesame sprout extracts 0.05 (30) Glycerin 1.0 (31) Ethanol 5.0 (32) Spices 0.1 (Note 15) PLANDOOL-MAS (manufactured by Nippon Seika Co., Ltd.) (Note 16) SIMULGEL EG QD (manufactured by SEPPIC)

(Production method) A: The components (1) to (5) are uniformly dissolved and mixed at 75°C. B: While maintaining the aforementioned A at 75°C, a part of the component (6) was added and stirred with a Disper mixer to obtain a vesicle dispersion. C: The remaining components (6) to (8) are uniformly dissolved and mixed at room temperature. D: The components (9) to (19) are uniformly dissolved and mixed at 80°C. E: The heated C is added while maintaining the D at 75°C to emulsify. F: After adding the mixing components (20) to (32) to the aforementioned E, it is cooled to 40°C to obtain an oil-in-water emulsion. The oil-in-water emulsion obtained above has excellent aggregation inhibition effect, penetrating feel, non-sticky feel, and excellent firmness of the skin after application.

Claims (7)

An external preparation for skin, which contains the following ingredients (A)~(D): (A) Nicotinamide 1-10% by mass, (B) Cationic surfactant, (C) Anionic polymer, (D) Water. Such as the skin external preparation of claim 1, which further contains a nonionic surfactant with a component (E) HLB of 10-18. The external skin preparation of claim 1 or 2, wherein the aforementioned component (B) contains dicocoylethyl hydroxyethylmonium methosulfate and/or alkyl trimethyl chloride. One type or two or more types of ammonium. The external preparation for skin according to any one of claims 1 to 3, wherein the aforementioned component (C) contains one or more selected from carboxyvinyl polymers and/or alkyl-modified carboxyvinyl polymers. The external preparation for skin according to any one of claims 1 to 4, wherein the aforementioned component (B) forms vesicle particles. A method for inhibiting agglomeration of cationic surfactants and anionic polymers, which is characterized by adding nicotine amide to skin external preparations containing cationic surfactants, anionic polymers and water In the amount of 1-10% by mass. A method for improving the stabilization of external skin preparations, which is characterized by adding nicotine amide to skin external preparations up to 1-10 in skin external preparations containing cationic surfactants, anionic polymers and water The amount of mass%.