WO2014069385A1

WO2014069385A1 - Composition for external use

Info

Publication number: WO2014069385A1
Application number: PCT/JP2013/079077
Authority: WO
Inventors: 映美武本; 幸恵武田
Original assignee: ロート製薬株式会社
Priority date: 2012-10-29
Filing date: 2013-10-28
Publication date: 2014-05-08
Also published as: CN104780902A; JPWO2014069385A1; JP6386911B2; HK1210709A1

Abstract

A composition for external use which comprises (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea and which is practically sufficiently inhibited from suffering a decrease in viscosity with the lapse of time and a decrease in use feeling or humectant performance which accompanies the viscosity decrease.

Description

Composition for external use

The present invention relates to a composition containing an acidic mucopolysaccharide, wherein the properties of the acidic mucopolysaccharide are maintained stably.

Skin has a reduced water retention function or skin barrier function due to various factors such as exposure to ultraviolet light, external factors such as changes in temperature or humidity, and internal factors such as aging. Various troubles such as dryness, itchiness, rash, soreness and sweat are caused. In order to improve these symptoms, it is first to remove the cause, but it is effective to normalize the moisture retention function or the skin barrier function by applying a pharmaceutical or cosmetic containing a moisturizing ingredient.

As the compound having moisturizing action, mucopolysaccharides such as hyaluronic acid, chondroitin sulfate, heparin, dermatan sulfate, heparan sulfate, and keratan sulfate are used. As a representative example, hyaluronic acid will be described. Hyaluronic acid is a mucopolysaccharide composed of glucuronic acid and N-acetylglucosamine, and is present in a large amount in the dermis as a bonding substance that fills cells and fibers in vivo. It is a substance that has been confirmed to exist in the epidermis and has high water retention and viscoelasticity. Because of these properties, it is used as a component such as eye drops for treating corneal epithelial disorders and injections for treating knee osteoarthritis in the medical field, and as a moisturizing agent in the cosmetic field.

Thus, mucopolysaccharide is a polysaccharide thickener that is widely used as a moisturizer for external preparations. In many cases, a surfactant is added to an external preparation from the viewpoint of formulation or use feeling, but mucopolysaccharides are known to decrease in viscosity when used in combination with a surfactant. This decrease in viscosity is particularly noticeable when the composition is exposed to light or heat. There is a problem that due to a decrease in the viscosity of the mucopolysaccharide, a moist and moist feeling that is a feeling of use of the composition containing the mucopolysaccharide is reduced. There is also a problem that the moisture retention function of the composition containing mucopolysaccharide is impaired.

On the other hand, various methods for suppressing the decrease in viscosity of mucopolysaccharides with time have been proposed.
For example, Patent Document 1 teaches that an external preparation for skin containing high molecular weight hyaluronic acid, low molecular weight hyaluronic acid, polyhydric alcohol, and edetate salt is excellent in moisture retention performance because the decrease in viscosity over time is suppressed. Yes.
In addition, Patent Document 2 shows that, by adding a specific vegetable oil to a mucosa-applied composition containing hyaluronic acid or a salt thereof, a decrease in viscosity of the composition is suppressed even when a surfactant is included. I teach.
Moreover, patent document 3 teaches that the viscosity fall of a composition is suppressed by mix | blending a fat-soluble vitamin with the liquid composition for mucosa containing a hyaluronic acid and surfactant.

However, the compositions described in these documents are not practically sufficient to suppress the decrease in the viscosity of the mucopolysaccharide over time and the accompanying deterioration in the feeling of use and moisturizing performance. Moreover, since the composition of patent document 2 and 3 mix | blends fat-soluble substances, such as vegetable oil and a fat-soluble vitamin, it is hard to maintain the transparency of a composition and it is hard to use it as external compositions, such as cosmetics.

Japanese Patent Laid-Open No. 1-190614 JP 2006-117656 A JP 2004-359629 A

The present invention provides an external composition containing an acidic mucopolysaccharide, in which a decrease in viscosity with time and a decrease in use feeling and moisturizing performance associated therewith over time are practically sufficiently suppressed. This is the issue.

The present inventor repeated research to solve the above problems, and when a compound having a polyoxyalkylene group is blended with acidic mucopolysaccharide, the viscosity of the composition tends to decrease over time. It has been found that, by blending, a decrease in viscosity of the composition with time is remarkably suppressed.

The present invention has been completed based on the above findings, and provides the following external compositions.
Item 1. An external composition comprising (a) acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea.
Item 2. Item 2. The composition for external use according to Item 1, wherein the hydroxyalkylurea is N- (2-hydroxyethyl) urea.
Item 3. Item 3. The topical composition according to Item 1 or 2, wherein the acidic mucopolysaccharide is selected from the group consisting of hyaluronic acid, chondroitin sulfate, and salts thereof.
Item 4. Item 4. The composition for external use according to any one of Items 1 to 3, wherein the compound having a polyoxyalkylene group is polyoxybutylene polyoxyethylene polyoxypropylene glycerin.
Item 5. Item 5. The composition for external use according to any one of Items 1 to 4, comprising 0.0001 to 2000 parts by weight of hydroxyalkylurea per 1 part by weight of the compound having a polyoxyalkylene group.
Item 6. Item 6. The composition for external use according to any one of Items 1 to 5, comprising 0.01 to 10,000 parts by weight of hydroxyalkylurea per 1 part by weight of acidic mucopolysaccharide.
Item 7. Item 7. The composition for external use according to any one of Items 1 to 6, comprising 0.000001 to 1% by weight of the acidic mucopolysaccharide based on the total amount of the composition.
Item 8. Item 8. The composition for external use according to any one of Items 1 to 7, comprising 0.001 to 30% by weight of hydroxyalkylurea based on the total amount of the composition.
Item 9. Item 9. The external composition according to any one of Items 1 to 8, wherein the compound having a polyoxyalkylene group is contained in an amount of 0.01 to 20% by weight based on the total amount of the composition.
Item 10. Item 10. The composition for external use according to any one of Items 1 to 9, which is used for moisturizing.
Item 11. Item 10. The composition for external use according to any one of Items 1 to 9, which is for imparting a tight feeling to the skin.
Item 12. A method for moisturizing the skin by applying an external composition containing (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea to human skin, or the skin A method of giving a moist, plump or sticky feeling.
Item 13. 13. A method according to claim 12, which is a non-therapeutic method.
Item 14. A combination of (a) acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea provides a moisturizing agent, or a moist, fluffy or sticky feeling to the skin. Non-therapeutic use as an agent.
Item 15. (A) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) for the manufacture of a skin moisturizer or an agent for imparting moist, plump or moist feeling to the skin, and (c) Combination use of hydroxyalkylurea.

Acid mucopolysaccharide is a general-purpose component added to the composition for external use in order to give viscosity and moisture retention performance. On the other hand, a compound having a polyoxyalkylene group is widely used as a component of an external composition because it functions as, for example, a nonionic surfactant. However, when a compound having a polyoxyalkylene group is added to a composition containing acidic mucopolysaccharide, the viscosity of the acidic mucopolysaccharide is impaired, particularly when the composition is exposed to heat or light. Will fall.
The composition for external use of the present invention includes a hydroxyalkyl urea in addition to the acidic mucopolysaccharide and the compound having a polyoxyalkylene group, so that the viscosity of the composition is reduced even when exposed to heat or light. Is significantly suppressed. As a result, the moisturizing performance is maintained for a long time, and the skin can be moist, fluffy and moist for a long time. In particular, a sticky feeling can be imparted.

It is a figure explaining the viscosity measuring method in an Example. It is a figure which shows the viscosity fall inhibitory effect of the composition by hydroxyethyl urea. The vertical axis represents relative viscosity (%). It is a figure which shows the viscosity fall inhibitory effect of the composition by hydroxyethyl urea. The vertical axis represents relative viscosity (%). It is a figure which shows the viscosity fall inhibitory effect of the composition by hydroxyethyl urea. The vertical axis represents relative viscosity (%). It is a figure which shows the viscosity fall inhibitory effect of the composition by hydroxyethyl urea. The vertical axis represents relative viscosity (%). It is a figure which shows the viscosity fall inhibitory effect of the composition by hydroxyethyl urea. The vertical axis represents relative viscosity (%). It is a figure which shows the viscosity fall inhibitory effect of the composition by hydroxyethyl urea. The vertical axis represents relative viscosity (%).

Hereinafter, the present invention will be described in detail.
The composition for external use of the present invention is a composition comprising (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea.

(a) Acid mucopolysaccharide An acidic mucopolysaccharide is a polysaccharide containing an amino sugar and uronic acid in its basic skeleton. Specific examples of the acidic mucopolysaccharide include hyaluronic acid, chondroitin sulfate, heparin, heparin-like substance, dermatan sulfate, heparan sulfate, and keratan sulfate I and II.

The acidic mucopolysaccharide may be a natural product, a natural product decomposed by a physical means such as acid or alkali, enzyme, ultrasonic wave or shear, or a natural product derivative.
For example, hyaluronic acid is a natural polymeric hyaluronic acid that is hydrolyzed in the presence of an acid such as hydrochloric acid, treated with an enzyme such as hyaluronidase, or physically by ultrasound or shear. It may be decomposed hyaluronic acid prepared by cutting. As the decomposed hyaluronic acid, a commercially available product such as hyarooligo (Kewpie Corporation) can be purchased.
Natural derivatives include acetylated hyaluronic acid, hydroxypropyltrimonium hyaluronate, and the like.

The acidic mucopolysaccharide may be a natural product, a degradation product of a natural product, or a salt of each of these derivatives. The salt may be a pharmaceutically or biologically acceptable salt, for example, an alkali metal salt such as sodium or potassium; an alkaline earth metal salt such as magnesium or calcium; a zinc salt; an ammonium salt; Examples thereof include alkanolamine salts such as monoethanolamine. Among these, alkali metal salts are preferable, and sodium salts are more preferable.
Preferred specific examples of acidic mucopolysaccharide salts include sodium hyaluronate, potassium hyaluronate, calcium hyaluronate, magnesium hyaluronate, zinc hyaluronate, ammonium hyaluronate, monoethanolamine hyaluronate, sodium acetylated hyaluronate, acetylated Potassium hyaluronate, calcium acetylated hyaluronate, magnesium acetylated hyaluronate, zinc acetylated hyaluronate, ammonium acetylated hyaluronate, monoethanolamine acetylated hyaluronate, sodium chondroitin sulfate, potassium chondroitin sulfate, sodium dermatan sulfate, dermatan sulfate Potassium, chitosan ascorbic acid, chitosan glycolic acid, chitosan lactic acid, chitosan hydroxypropyltrimonium Rorido, sodium heparan sulfate, heparan potassium sulfate.

Among acidic mucopolysaccharides, hyaluronic acid, sodium hyaluronate, chondroitin sulfate, sodium chondroitin sulfate, sodium acetylated hyaluronate, potassium acetylated hyaluronate, calcium acetylated hyaluronate, magnesium acetylated hyaluronate, acetylated hyaluronic acid Zinc is preferred, hyaluronic acid, sodium hyaluronate, chondroitin sulfate, chondroitin sulfate sodium, acetylated sodium hyaluronate, acetylated potassium hyaluronate, and acetylated zinc hyaluronate are more preferred, and hyaluronic acid and sodium hyaluronate are even more preferred.

An acidic mucopolysaccharide can be used singly or in combination of two or more.
The origin of the acidic mucopolysaccharide is not particularly limited as long as it can be used in the fields of pharmaceuticals, quasi drugs, and cosmetics.

The average molecular weight of the acidic mucopolysaccharide is not particularly limited, and is, for example, about 1,000 to 4,000,000, preferably about 1,000 to 3,000,000, more preferably about 5,000 to 3,000,000, particularly preferably about 5,000 to 2,000,000. is there.

The content of the acidic mucopolysaccharide in the composition for external use is preferably 0.000001% by weight or more, more preferably 0.001% by weight or more, and still more preferably 0.01% by weight or more based on the total amount of the composition. preferable. If it is this range, sufficient viscosity and moisture retention performance can be given to an external composition. Further, the content of the acidic mucopolysaccharide in the composition for external use is preferably 1% by weight or less, more preferably 0.5% by weight or less, and even more preferably 0.25% by weight or less based on the total amount of the composition. preferable. If it is this range, stickiness will be suppressed and a favorable usability | use_condition can be given.

(b) Compound having polyoxyalkylene group The polyoxyalkylene group is a functional group represented by the following general formula (1).

(O (CH ₂ ) m) n- (1)

In the functional group represented by the above formula (1) in the compound having a polyoxyalkylene group used in the present invention, m is, for example, 1 to 4, preferably 2 to 4. Specific examples include a polyoxymethylene group, a polyoxyethylene group, a polyoxypropylene group, and a polyoxybutylene group.
In the above formula (1), n is, for example, 2 to 150, preferably 5 to 100, and more preferably 10 to 30.

A typical example of a compound having a polyoxyalkylene group is polyoxyalkylene glyceryl ether in which a polyoxyalkylene group is ether-bonded to 1 to 3 of 3 carbons of glycerin. Fatty acids may be ester-bonded to carbon to which no polyoxyalkylene group is bonded.

Specifically, polyoxymethylene glyceryl ether, polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxybutylene glyceryl ether, polyoxymethylene / polyoxyethylene glyceryl ether, polyoxymethylene / polypropylene glyceryl ether, polyoxy Methylene polyoxybutylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxybutylene glyceryl ether, polyoxypropylene polyoxybutylene glyceryl ether, polyoxymethylene polyoxyethylene polyoxypropylene glyceryl Ether, polyoxymethylene, polyoxyethylene, polyoxybutylene glyceryl ether , Polyoxypropylene polyoxyethylene polyoxybutylene glyceryl ether, polyoxypropylene polyoxymethylene-polyoxybutylene glyceryl ether and the like.
Among them, glyceryl ether having a polyoxybutylene group is preferable, and polyoxymethylene, polyoxyethylene, polyoxybutylene glyceryl ether, polyoxybutylene, polyoxyethylene, polyoxypropylene glyceryl ether, polyoxypropylene, polyoxymethylene, poly Oxybutylene glyceryl ether is more preferred, and polyoxybutylene / polyoxyethylene / polyoxypropylene glyceryl ether is even more preferred.
Examples of commercially available products of polyoxybutylene, polyoxyethylene, and polyoxypropylene glyceryl ether include, for example, Willbride S-753 (manufactured by NOF Corporation; polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O) (8E .O) (5P.O)) and the like can be used.

Polyoxyalkylene glyceryl ethers containing fatty acid residues include polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl tristearate, polyoxyethylene glyceryl isostearate, polyoxyethylene glyceryl triisostearate, polyoxyethylene isostearate Examples thereof include glyceryl, polyoxyethylene glyceryl diisostearate, polyoxyethylene glyceryl triisostearate, polyoxyethylene glyceryl trioleate, and polyoxyethylene monococonut oil fatty acid glyceryl.

A compound having a polyoxyalkylene group can be used singly or in combination of two or more.

The content of the compound having a polyoxyalkylene group in the external composition is preferably 0.01% by weight or more, more preferably 0.05% by weight or more, and more preferably 0.1% by weight or more based on the total amount of the composition. Is even more preferred. If it is this range, normally the effect | action of the compound which has a polyoxyalkylene group will fully be acquired. Further, the content of the compound having a polyoxyalkylene group in the composition for external use is preferably 20% by weight or less, more preferably 15% by weight or less, still more preferably 10% by weight or less based on the total amount of the composition. . If it is this range, a favorable usability | use_condition can be provided.

(c) Hydroxyalkylurea Hydroxyalkylurea refers to a compound in which at least one hydrogen atom of urea is substituted with a hydroxyalkyl group. That is, the hydroxyalkyl urea referred to in the present invention is a compound represented by the following general formula (2).

R ¹ R ² N—CO—NR ³ R ⁴ (2)
(Wherein R ¹ , R ² , R ³ , and R ⁴ each independently represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or a hydroxyalkyl group having 2 to 6 carbon atoms, and (At least one of R ¹ , R ² , R ³ , and R ⁴ is a hydroxyalkyl group having 2 to 6 carbon atoms.)

Specific examples of the hydroxyalkyl group include a hydroxyethyl group, a hydroxypropyl group, a hydroxybutyl group, a dihydroxybutyl group, a hydroxypentyl group, and a hydroxyhexyl group. Of these, a hydroxyethyl group is preferable.
More specifically, hydroxyalkylureas include N- (2-hydroxyethyl) urea, N- (2-hydroxypropyl) urea, N- (3-hydroxypropyl) urea, N- (2,3-dihydroxypropyl). ) Urea, N- (2-hydroxybutyl) urea, N- (3-hydroxybutyl) urea, N- (4-hydroxybutyl) urea, N- (2,3-dihydroxybutyl) urea, N- (2, 4-dihydroxybutyl) urea, N- (3,4-dihydroxybutyl) urea, N-ethyl-N ′-(2-hydroxyethyl) urea, N, N-bis (2-hydroxyethyl) urea, N, N '-Bis (2-hydroxyethyl) urea, N, N-bis (2-hydroxypropyl) urea, N, N'-bis (2-hydroxypropyl) urea, N, N-bis (2-hydroxyethyl) ) -N'-propylurea, N, N'-bis (2-hydroxypropyl) -N '-(2-hydroxyethyl) urea, N-tert-butyl-N'-(2-hydroxyethyl) -N '-(2-hydroxypropyl) urea, N, N-bis (2-hydroxyethyl) -N', N'-dimethylurea, N, N, N ', N'-tetrakis- (2-hydroxyethyl) urea And N, N-bis (2-hydroxyethyl) -N ′, N′-bis (2-hydroxypropyl) urea and the like.
The number of hydroxyalkyl groups in the hydroxyalkylurea is preferably 1 to 3, more preferably 1 to 2, and even more preferably 1 (monohydroxyalkylurea). Of these, hydroxyethylurea is preferred.

Hydroxyalkyl urea can be used singly or in combination of two or more.

The content of hydroxyalkyl urea in the composition for external use is preferably 0.001% by weight or more, more preferably 0.01% by weight or more, and still more preferably 0.1% by weight or more based on the total amount of the composition. . Within this range, the effects of the present invention (suppression of the time-dependent decrease in the viscosity, moisture retention performance, moist feeling and moist feeling imparting performance of the composition) can be sufficiently obtained. The content of hydroxyalkyl urea in the external composition is preferably 30% by weight or less, more preferably 20% by weight or less, and still more preferably 10% by weight or less based on the total amount of the composition. If it is this range, the effect of said this invention will fully be acquired.

Further, the ratio of the content of hydroxyalkylurea to the content of the compound having a polyoxyalkylene group is preferably 0.0001 part by weight or more with respect to 1 part by weight of the compound having a polyoxyalkylene group, and 0.01 wt. Part or more is more preferable, and 0.1 part by weight or more is even more preferable. Within this range, the effects of the present invention (suppression of the time-dependent decrease in the viscosity, moisture retention performance, moist feeling and moist feeling imparting performance of the composition) can be sufficiently obtained. The ratio of the hydroxyalkylurea content to the content of the compound having a polyoxyalkylene group is preferably 500 parts by weight or less, more preferably 200 parts by weight or less, relative to 1 part by weight of the compound having a polyoxyalkylene group. Preferably, 100 parts by weight or less is even more preferable. If it is this range, the effect of said this invention will fully be acquired.

Further, the ratio of the content of hydroxyalkylurea to the content of acidic mucopolysaccharide is preferably 0.01 parts by weight or more, more preferably 1 part by weight or more, with respect to 1 part by weight of acidic mucopolysaccharide. Part or more is even more preferable. Within this range, the effects of the present invention (suppression of the time-dependent decrease in the viscosity, moisture retention performance, moist feeling and moist feeling imparting performance of the composition) can be sufficiently obtained. Further, the ratio of the content of hydroxyalkylurea to the content of acidic mucopolysaccharide is preferably 10,000 parts by weight or less, more preferably 500 parts by weight or less, and more preferably 100 parts by weight or less with respect to 1 part by weight of acidic mucopolysaccharides. Is even more preferred. If it is this range, the effect of said this invention will fully be acquired.

Formulation The composition for external use of the present invention is prepared by mixing the components (a) to (c) described above together with a base or carrier that can be used in cosmetics, and optionally additives and other active ingredients, For example, it can be set as the external composition for cosmetics.

The property of the composition is not particularly limited, and can be a liquid, fluid, or semi-solid preparation, for example, liquid, suspension, emulsion, cream, ointment, gel, liniment. , A preparation such as a lotion, an aerosol, or a sheet obtained by impregnating a nonwoven fabric with a chemical. Of these, emulsions, creams, emulsions, ointments, gels, and lotions are preferred, and creams, emulsions, ointments, and gels are particularly preferred.
The specific use of cosmetics is not particularly limited, and lotions, emulsions, gels, creams, serums, sunscreen cosmetics, basic cosmetics such as packs, masks, hand creams, body lotions, body creams; Cosmetics, makeup removers, body shampoos, shampoos, rinses, cleaning cosmetics such as treatments; foundations, makeup cosmetics such as various colors, and the like.

As a base or carrier bases or carriers, paraffin, liquid paraffin, squalane, white wax, hydrocarbon gel (such as Plastibase), ozokerite, ceresin, vaseline, hard fat, microcrystalline wax, alpha-olefin oligomers, light liquid Hydrocarbons such as paraffin; fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid; glyceryl tri-2-ethylhexanoate (trioctanoin), tri (caprylic acid / capric acid) Tri-fatty acid glycerides such as glyceryl; higher alcohols such as cetanol, stearyl alcohol, and behenyl alcohol; methyl polysiloxane, highly polymerized methyl polysiloxane, dimethylsiloxane methyl (polyoxyethylene) siloxane -Methyl (polyoxypropylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxyethylene) siloxane copolymer, dimethylsiloxane-methyl (polyoxypropylene) siloxane copolymer, polyoxyethylene-methylpolysiloxane copolymer Polymer, poly (oxyethylene / oxypropylene) / methylpolysiloxane copolymer, dimethylsiloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl acrylate copolymer methylpolysiloxane ester , Crosslinked methylpolysiloxane, crosslinked methylphenylpolysiloxane, crosslinked polyether-modified silicone, crosslinked alkylpolyether-modified silicone, crosslinked alkyl-modified silicone, decamethyl Such as cyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, methylsiloxane network polymer, polyoxyethylene-methylpolysiloxane copolymer, methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyldimethicone, dimethylpolysiloxane Silicone oils such as ethylene glycol monoacetate, ethylene glycol diacetate, triethylene glycol diacetate, hexylene glycol diacetate, and 2-methyl-2-propene-1,1-diol diacetate Glycol acetate; Triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 2,2,4-trimethyl-1,3-pentanedio Glycol esters such as rudiisobutyrate; ethylene glycol diacrylate, diethylene glycol diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate, and 1,3-butylene glycol diacrylate Glycol acrylates such as: ethylene glycol dinitrate, diethylene glycol dinitrate, triethylene glycol dinitrate, and glycol dinitrates such as propylene glycol dinitrate; 2,2 ′-[1,4-phenylenedioxy] diethanol; Cellulose derivatives such as ethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose; polyvinylpyrrolidone; carrageenan; polyvinyl Polyethylene glycol; Dioxane; Butylene glycol adipate polyester; Esters such as isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrite tetra-2-ethylhexanoate; dextrin Polysaccharides such as maltodextrin; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol Monobutyl ether, propire Glycol ethers such as diglycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether and dipropylene glycol monopropyl ether; water-based bases such as water.

Among them, hydrocarbons (especially α-olefin oligomers, squalane, light liquid paraffin, liquid paraffin), tri fatty acid glycerides (especially glyceryl tri-2-ethylhexanoate, tri (caprylic acid / capric acid) glyceryl), higher alcohols ( In particular, cetanol, stearyl alcohol, behenyl alcohol), silicone oil (especially methylpolysiloxane, alkyl acrylate copolymer methylpolysiloxane ester, cross-linked methylpolysiloxane, decamethylcyclopentasiloxane, ethyltrisiloxane, methyltrimethicone, Methylsiloxane network polymer, polyoxyethylene / methylpolysiloxane copolymer, methylhydrogenpolysiloxane, triethoxysilylethylpolydimethylsiloxyethylhexyl dimethicone, dimethicone Polysiloxane), esters (especially isononyl isononanoate, pentaerythritol tetra-2-ethylhexanoate), polysaccharides (especially dextrin, maltodextrin), glycol ethers (especially diethylene glycol monoethyl ether), water are preferred. .
A base or a carrier can be used alone or in combination of two or more.

Additives In the composition for external use of the present invention, known additives to be added to cosmetics, for example, antioxidants, surfactants, thickeners, preservatives, pH adjustments, as long as the effects of the present invention are not impaired. Agents, stabilizers, irritation reducers, preservatives, colorants, fragrances, pearlescent agents and the like can be added.
Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivatives, tocopherol, tocopherol derivatives, erythorbic acid, L-cysteine hydrochloride and the like.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate. Sorbitan fatty acid esters; propylene glycol fatty acid esters such as propylene glycol monostearate; glycerin alkyl ethers; alkyl glucosides; amines such as stearylamine and oleylamine; polyoxyethylene-methylpolysiloxane copolymer, lauryl PEG Examples thereof include silicone surfactants such as -9 polydimethylsiloxyethyl dimethicone and PEG-9 polydimethylsiloxyethyl dimethicone.

Examples of the thickener include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, macrogol, and cellulose series. Examples include thickeners (such as methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and carboxyethylcellulose) and salts thereof.

Examples of preservatives and preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxybenzoic acid Examples include benzyl, methyl paraoxybenzoate, phenoxyethanol, benzyl alcohol, chlorobutanol, sorbic acid and its salt, chlorhexidine gluconate, alkanediol, and glycerin fatty acid ester.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, sodium hydroxide, etc.) ) And organic bases (such as triethanolamine, diisopropanolamine, and triisopropanolamine).

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole, edetate and the like.
Examples of the irritation reducing agent include licorice extract and sodium alginate.

Additives can be used singly or in combination of two or more.

Other active ingredients The composition for external use of this invention can contain another active ingredient in the range which does not impair the effect of this invention. Specific examples of active ingredients include, for example, moisturizing ingredients, anti-inflammatory ingredients, antibacterial ingredients, vitamins, peptides or derivatives thereof, cell activation ingredients, anti-aging ingredients, blood circulation promoting ingredients, keratin softening ingredients, whitening ingredients, astringent ingredients Etc.

Moisturizing ingredients include high molecular weight compounds such as collagen, elastin, keratin, chitin and chitosan; natural moisturizing factors such as sodium lactate, urea and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol and phospholipid; chamomile extract , Plant extract extracts such as hamamelis extract, tea extract and perilla extract.

Examples of the anti-inflammatory component include a plant-derived component (eg Comfrey), allantoin, glycyrrhizic acid or a derivative thereof, zinc oxide, pyridoxine hydrochloride, tocopherol acetate, salicylic acid or a derivative thereof, and ε-aminocaproic acid.

Antibacterial or bactericidal components include ethanol, chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, sulfur, resorcin, benzethonium chloride, adapalene, benzoyl peroxide, clindamycin, cresol, gluconic acid and its derivatives, popidone iodine, potassium iodide , Iodine, isopropylmethylphenol, triclocarban, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, chlorhexidine gluconate, zinc paraphenolsulfonate, etc. It is done.

Vitamins include retinol, retinol acetate, retinol palmitate, etc., retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinol retinoic acid, d-δ-tocopheryl retinoate, α-tocopheryl retinoate Vitamin A such as β-tocopheryl retinoate; vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate; riboflavin, Vitamin B2 such as flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-sodium phosphate, riboflavin tetranicotinate Nicotinic acids such as dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate; ascorbigen-A, ascorbic acid stearate, Vitamin Cs such as ascorbyl palmitate, L-ascorbyl dipalmitate; Vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol; Vitamin K such as phylloquinone, farnoquinone, γ-oryzanol, dibenzoylthiamine , Dibenzoylthiamine hydrochloride; thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate , Vitamin B1 such as thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate, thiamine triphosphate, thiamine triphosphate monophosphate; pyridoxine hydrochloride, pyridoxine acetate, Vitamin B6 such as pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride; vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin; folic acid such as folic acid, pteroylglutamic acid; nicotinic acid, nicotinamide, etc. Nicotinic acids: pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-pantetheine, D-pantethine, coenzyme A, pantothenyl ethyl ether, etc. Tennic acids; biotins such as biotin and bioticin; vitamins C which are ascorbic acid derivatives such as ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate sodium, magnesium ascorbate phosphate; carnitine, ferulic acid And vitamin-like agents such as α-lipoic acid and orotic acid.

Peptides or derivatives thereof include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degrading peptide , Conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, hydrolyzed soy protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide Acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

Cell activating components include vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponins, allantoins, and photosensitizer 301. .
Antiaging components include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone, and the like.

Examples of the blood circulation promoting component include plants (for example, ginseng, ashitaba, arnica, ginkgo, fennel, enamel, Dutch oak, chamomile, roman chamomile, carrot, gentian, burdock, rice, hawthorn, shiitake, hawthorn, sorghum, nematode, Assembly, thyme, clove, chimney, spruce, spruce, spruce, carrot, garlic, butcher bloom, grape, button, maronier, melissa, yuzu, yokuinin, rosemary, rosehip, chimpy, touki, spruce, peach, apricot, walnut , A component derived from corn); and glucosyl hesperidin.

Examples of the keratin softening component include salicylic acid, glycolic acid, fruit acid, phytic acid, and sulfur.
Examples of the whitening component include ascorbic acid and its derivatives, arbutin, and tocopherol.
Examples of the astringent component include zinc paraphenol sulfonate, zinc oxide, menthol and ethanol.

Other active ingredients can be used alone or in combination of two or more.

Method of Use The method of using the composition for external use of the present invention varies depending on the skin condition, age, sex, etc. of the subject of use, but may be the following method, for example. That is, an appropriate amount (for example, about 0.05 to 5 g) may be applied (applied, sprayed, affixed, etc.) to the skin several times a day (for example, about 1 to 5 times, preferably 1 to 3 times). Further, the composition may be applied so that the daily use amount of the acidic mucopolysaccharide is, for example, about 0.00005 to 0.025 g.
The composition for external use of the present invention can be applied to any skin such as face, neck, hand, foot, finger, torso, scalp and the like.

Uses The composition for external use of the present invention can be, for example, an external composition for moisturizing or imparting a moist, fluffy, or sticky feeling to the skin.
Sticky feeling means that after the preparation applied to the skin is lightly rubbed into the skin with a finger or palm, the applied preparation leaves a feeling left between the finger and the skin, and the finger or palm with the preparation extended. When the skin is separated from the skin, the skin to which the preparation is applied has a feeling of sticking to the finger or palm.

The present invention includes the above-described external composition of the present invention comprising (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea. A method of moisturizing the skin by applying to the skin of hands, feet, fingers, torso, scalp, etc. (application, spraying, sticking, etc.) and a method of giving the skin a moist, plump or moist feeling Include. These methods can be non-therapeutic methods.
The method of using the external composition of the present invention in these methods is as described for the external composition of the present invention.

Further, the present invention is a combination of (a) acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea, a skin moisturizer, and a moist feeling on the skin, a fluffy feeling, Or includes non-therapeutic use as a moisturizing agent.
The present invention also includes (a) an acidic mucopolysaccharide and (b) a polyoxyalkylene group for the production of a skin moisturizing agent, and a moisturizing, plump or moisturizing agent for the skin. Includes the combined use of a compound and (c) a hydroxyalkylurea.
The components, dosage forms, and methods of using these agents are as described for the external composition of the present invention.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to these examples.

Test example 1 (thermal stability test)
(1) Preparation of composition The compositions of Examples and Comparative Examples are shown in Tables 1 and 2 below. In addition, all the numerical values in Table 1 and Table 2 show weight%.

(2) Test method (viscosity measurement)
The compositions of Examples and Comparative Examples having the compositions shown in Table 1 and Table 2 were prepared.
Viscosity of each composition immediately after preparation and stored product (stored at 60 ° C. for 1 week) was measured for 12 hours at 25 ° C. ± 1 ° C., and then the viscosity was measured. Viscosity reduction was expressed as the relative viscosity of the stored product (stored at 60 ° C. for 1 week), with the viscosity immediately after preparation as 100%. That is, the relative viscosity of each composition was calculated by the following formula.

Relative viscosity (%)
= (Viscosity of stored product (60 ° C., 1 week) / viscosity immediately after preparation) × 100

The viscosity measurement conditions are as follows.
In accordance with the test method of “(2) Cone-plate rotational viscometer (cone plate viscometer)” described in the 16th revision Japanese Pharmacopoeia General Test Method Viscosity Measurement Method Second Method Rotary Viscometer Method, The viscosity was measured using RE85 (Toki Sangyo). That is, the measurement temperature was 25 ° C. ± 1 ° C., and the measurement was performed by measuring the viscosity every minute up to 3 minutes and using the average value of 3 times.
Basically, as shown in FIG. 1, a sample is put into a gap of an angle α between the cone 1 and the flat disc 2 and the cone 1 or the flat disc 2 is rotated at a constant angular velocity ω or torque T. Then, the torque or angular velocity received by the flat disk 2 or the cone 1 when the steady state is reached is measured, and the viscosity η of the sample is calculated by the following equation.

η = 100 × (3α / 2πR3) · (T / ω)

η: Viscosity of sample (mPa · s) (Pa · s = 103 mPa · s)
α: Angle formed by flat disk 2 and cone 1 (rad)
π: Circumference ratio R: Conical radius (cm)
T: Torque acting on the flat disk 2 or the conical surface (10 @ -7 N.m)
ω: Angular velocity (rad / s)

(Usability test)
Three expert panelists dropped the compositions of the examples and comparative examples used in the viscosity test of Test 1 by 0.5 ml on the inner side of the forearm and spread them over a range of 2 cm × 2 cm. After 5 minutes, The “feeling of being sticky” was evaluated according to the evaluation criteria of the following usability index.

5: There is a considerable “feeling of stickiness”.
4: There is a “sticky feeling”.
3: If anything, there is a “sticky feeling”.
2: Not very “sticky”.
1: There is no “feeling of stickiness”.

(3) Test results (viscosity measurement)
The measurement results of the viscosity are shown in FIGS.
As is clear from FIGS. 2-5, the comparison includes sodium hyaluronate and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O) (8E.O) (5P.O), but does not contain hydroxyethylurea The compositions of Examples 1 to 4 showed a significant decrease in viscosity over time, but the compositions of Examples 1 to 6 in which hydroxyethylurea was blended with this significantly suppressed the decrease in viscosity over time.

(Usability test)
The results are shown in Table 3 below. As a result of comparing the change in “feel of stickiness” between the product immediately after preparation and the stored product (stored at 60 ° C. for 1 week), the usability index of the examples exceeded that of the comparative examples. It was confirmed that the hydroxyethylurea compound suppresses the reduction of “stickiness” caused by thermal aging.

Test example 2 (light stability test)
(1) Preparation of composition The composition of each Example and Comparative Example is shown in Table 4 below. In addition, all the numerical values in Table 4 show weight%.

(2) Test method (viscosity measurement)
Each composition of the Example and comparative example which have a composition shown in Table 4 was prepared.
Each composition was filled in a 30 mL capacity glass container, and the viscosity at 25 ° C. was measured to obtain the initial viscosity. Thereafter, light irradiation corresponding to 10,000 kJ / m ² was performed with SUNTEST XLS + (Toyo Seiki Seisakusho), and immediately after that, the viscosity at 25 ° C. was measured.
The viscosity of each of the unirradiated sample and the irradiated sample was measured under 25 ° C ± 1 ° C conditions. The viscosity measurement conditions are the same as in Test Example 1. The decrease in viscosity was expressed as a relative viscosity after irradiation with the unirradiated sample as 100%. That is, the relative viscosity of each composition was calculated by the following formula.

Relative viscosity (%) = (viscosity of irradiated sample / viscosity of unirradiated sample) × 100

(Usability test)
About the Example and comparative example which were used in the viscosity test of Test 2, three expert panelists dropped 0.5 ml of each composition on the inner side of the forearm and spread it over a range of 2 cm × 2 cm. The “feel” was evaluated according to the evaluation criteria of the following usability index. The method for the usability test is the same as in Test Example 1.

(3) Test results (viscosity measurement)
The results of the viscosity measurement are shown in FIGS. As apparent from FIGS. 6 and 7, it contains sodium hyaluronate and polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.O) (8E.O) (5P.O) and does not contain hydroxyethyl urea. The compositions of Comparative Examples 2 and 5 had a significant decrease in viscosity over time, but the compositions of Examples 7 and 8 in which hydroxyethylurea was blended with this significantly suppressed the decrease in viscosity over time. .

(Usability test)
The results are shown in Table 5 below. As a result of comparing the change in “feel of stickiness” between the ultraviolet irradiated sample and the unirradiated sample, the usability index of each example exceeded that of the comparative example. It was confirmed that the hydroxyethylurea compound suppresses the reduction of “stickiness” caused by thermal aging.

Formulation Examples Hereinafter, specific formulation examples of the composition for external use of the present invention will be exemplified. The unit of the content of the component in the formulation example is “wt%”.

Formulation Example 1 Cosmetic liquid Hydroxyethylurea 5.0
Diglycerin 5.0
Dipropylene glycol 7.0
Sorbitol 2.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
2.0
Hydroxyethyl cellulose 0.2
Sodium hyaluronate 0.1
Acetylated sodium hyaluronate 0.05
Hydrolyzed hyaluronic acid 0.02
Preservatives (methyl paraoxybenzoate, phenoxyethanol) Appropriate amount pH adjuster Appropriate amount
Purified water balance
Total 100

Formulation Example 2 Latex Hydroxyethylurea 10.0
Concentrated glycerin 5.0
1,3-butylene glycol 5.0
Dipropylene glycol 5.0
Carboxyvinyl polymer 0.2
Acrylic acid / alkyl methacrylate copolymer 0.5
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
3.0
Polyoxyethylene hydrogenated castor oil 3.0
Glyceryl stearate 1.0
Squalane 5.0
α-Olefin oligomer 3.0
Sodium hyaluronate 0.2
Hydrolyzed collagen powder 0.02
Methyl polysiloxane 0.5
Chelating agent Suitable amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate, phenoxyethanol)
Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance
Total 100

Formulation Example 3 Gel cream Hydroxyethylurea 8.0
Concentrated glycerin 5.0
1,3-butylene glycol 5.0
Dipropylene glycol 5.0
1,2-pentanediol 3.0
(Acroyldimethyltaurine ammonium / vinylpyrrolidone) copolymer 2.0
Kangten 0.3
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
5.0
Squalane 4.0
Glyceryl tri-2-ethylhexanoate 5.0
Sodium hyaluronate 0.3
Acetylated sodium hyaluronate 0.01
Hydrolyzed hyaluronic acid 0.02
Hydrolyzed collagen powder 0.05
Glucosylceramide 0.01
Methyl polysiloxane 0.5
Chelating agent Suitable amount of preservative (methyl paraoxybenzoate, propyl paraoxybenzoate, phenoxyethanol)
Appropriate amount of pH adjuster Appropriate amount of perfume Appropriate amount
Purified water balance
Total 100

Formulation Example 4 Latex Hydroxyethylurea 3.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
5.0
Sodium hyaluronate 0.05
Sorbitan monostearate 0.6
Polyoxyethylene sorbitan isostearate (20.EO.) 0.8
1,3-butylene glycol 3
Microcapsules containing organic fluorescent agent 15
Dipropylene glycol 3
Behenyl alcohol 0.3
Stearyl alcohol 0.4
Alpha olefin oligomer 8
Tri (capryl / caprin / myristin / stearic acid) glyceride 0.5
Acrylic acid / alkyl methacrylate copolymer 0.4
Liquid paraffin 5
Sodium edetate 0.05
pH adjuster appropriate amount preservative appropriate amount
Purified water remaining
Total 100
The organic fluorescent agent-containing microcapsules are produced by the method described in Example 1 of WO2012 / 102397.

Formulation Example 5 Gel lotion Hydroxyethylurea 5.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
0.5
Sodium hyaluronate 0.1
Polyoxyethylene sorbitan isostearate (20. EO.) 0.6
Organic fluorescent agent-containing microcapsules 5
Carboxyvinyl polymer 0.15
Hydroxyethyl cellulose 0.1
Dipropylene glycol 3
Glycerin 5
1,3-butylene glycol 7
Tri (capryl / capric) glyceryl 3
Sodium edetate 0.05
pH adjuster appropriate amount preservative appropriate amount
Purified water remaining
Total 100
The organic fluorescent agent-containing microcapsules are produced by the method described in Example 1 of WO2012 / 102397.

Formulation Example 6 Gel serum for hydroxyethylurea 10.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
3.0
Sodium hyaluronate 0.2
Sorbitan monoisostearate0.4
Polyoxyethylene sorbitan isostearate (20. EO.) 0.4
Carboxyvinyl polymer 0.3
Xanthan gum 0.05
Dipropylene glycol 3
Glycerin 5
Behenyl alcohol 0.2
Stearyl alcohol 0.3
Tri (capryl / capric) glyceryl 3
1,3-butylene glycol 5
Organic fluorescent agent-containing microcapsules 3
Sodium edetate 0.05
pH adjuster appropriate amount preservative appropriate amount
Purified water remaining
Total 100
The organic fluorescent agent-containing microcapsules are produced by the method described in Example 2 of WO2012 / 102397.

Formulation Example 7 Latex Hydroxyethylurea 7.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
10.0
Sodium hyaluronate 0.3
Sorbitan monostearate 0.6
Polyoxyethylene sorbitan isostearate (20.EO.) 0.8
1,3-butylene glycol 3
Microcapsules containing organic fluorescent agents 20
Dipropylene glycol 3
Soy hydrolyzate 0.01
Sodium edetate 0.05
Behenyl alcohol 0.3
Stearyl alcohol 0.4
Tri (Capryl / Capric Acid) Glyceryl 4
Alpha olefin oligomer 8
Tri (capryl / caprin / myristin / stearic acid) glyceride 0.5
Acrylic acid / alkyl methacrylate copolymer 0.4
pH adjuster appropriate amount preservative appropriate amount
Purified water remaining
Total 100
The organic fluorescent agent-containing microcapsules are produced by the method described in Example 2 of WO2012 / 102397.

Formulation Example 8 Cream Hydroxyethylurea 15.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
7.0
Sodium hyaluronate 0.15
Sorbitan monostearate1.2
Polyoxyethylene sorbitan isostearate (20. EO.) 1.2
Carboxyvinyl polymer 0.2
Pullulan 0.2
Hydrolyzed collagen 0.05
Hydroxyethyl cellulose 0.05
1,3-butylene glycol 10
Tri (Capryl / Capric Acid) Glyceryl 8
Microcapsules containing organic fluorescent agent 10
Jojoba oil 5
Tri (capryl / caprin / myristin / stearic acid) glyceride 3
Xanthan gum 0.05
Glycerin 5
Dipropylene glycol 2
Sodium edetate 0.05
Behenyl alcohol 1.5
Cetanol 1.5
pH adjuster appropriate amount preservative appropriate amount
Purified water remaining
Total 100
The organic fluorescent agent-containing microcapsules are produced by the method described in Example 3 of WO2012 / 102397.

Formulation Example 9 Cream Hydroxyethylurea 20.0
Polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3B.0) (8E.0) (5P.0)
15.0
Sodium hyaluronate 0.5
Glycerol monostearate1.6
Polyglyceryl monostearate2.0
Xanthan gum 0.1
1,3-butylene glycol 5
Glycerin 5
Dipropylene glycol 2
Sodium edetate 0.05
Behenyl alcohol 2
Squalane 5
Glyceryl tri-2-ethylhexanoate 5
Tri (capryl / caprin / myristin / stearic acid) glyceride 3
Microcapsules containing organic fluorescent agent 15
Acrylic acid / alkyl methacrylate copolymer 0.2
pH adjuster appropriate amount preservative appropriate amount
Purified water remaining
Total 100
The organic fluorescent agent-containing microcapsules are produced by the method described in Example 4 of WO2012 / 102397.

In the composition for external use of the present invention, the decrease in the viscosity of the acidic mucopolysaccharide over time is suppressed, and a good feeling of use with viscosity is maintained for a long time. Along with this, a decrease in the moisture retention performance and the moist or moist feeling imparting performance is also suppressed. Thus, the composition for external use of the present invention has high commercial value because the properties of the acidic mucopolysaccharide are not deteriorated by distribution and storage.

Claims

External composition containing (a) acidic mucopolysaccharide, (b) compound having polyoxyalkylene group, and (c) hydroxyalkylurea.
The composition for external use according to claim 1, wherein the hydroxyalkylurea is N- (2-hydroxyethyl) urea.
The composition for external use according to claim 1 or 2, wherein the acidic mucopolysaccharide is selected from the group consisting of hyaluronic acid, chondroitin sulfate, and salts thereof.
The composition for external use according to any one of claims 1 to 3, wherein the compound having a polyoxyalkylene group is polyoxybutylene polyoxyethylene polyoxypropylene glycerin.
The composition for external use according to any one of claims 1 to 4, comprising 0.0001 to 2000 parts by weight of hydroxyalkylurea per 1 part by weight of the compound having a polyoxyalkylene group.
The composition for external use according to any one of claims 1 to 5, comprising 0.01 to 10,000 parts by weight of hydroxyalkylurea per 1 part by weight of acidic mucopolysaccharide.
The composition for external use according to any one of claims 1 to 6, comprising 0.000001 to 1% by weight of acidic mucopolysaccharide based on the total amount of the composition.
The composition for external use according to any one of Claims 1 to 7, comprising 0.001 to 30% by weight of hydroxyalkylurea based on the total amount of the composition.
The composition for external use according to any one of claims 1 to 8, comprising a compound having a polyoxyalkylene group in an amount of 0.01 to 20% by weight based on the total amount of the composition.
The composition for external use according to any one of claims 1 to 9, which is used for moisturizing.
The composition for external use according to any one of claims 1 to 9, which is for imparting a tight feeling to the skin.
A method for moisturizing the skin by applying an external composition containing (a) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) a hydroxyalkylurea to human skin, or the skin A method of giving a moist, plump or sticky feeling.
The method according to claim 12, which is a non-therapeutic method.
A combination of (a) acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) hydroxyalkylurea provides a moisturizing agent, or a moist, fluffy or sticky feeling to the skin. Non-therapeutic use as an agent.
(A) an acidic mucopolysaccharide, (b) a compound having a polyoxyalkylene group, and (c) for the manufacture of a skin moisturizer or an agent for imparting moist, plump or moist feeling to the skin, and (c) Combination use of hydroxyalkylurea.