JP2010070526A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a urea derivative excellent in stability over time and pH stability of its aqueous solution, formulable in a cosmetic and skin preparation for external use by using water as a medium, also showing an excellent hair-improving effect on damaged hair and having a high moisturizing effect, and the cosmetic and skin preparation for external use containing the urea derivative. <P>SOLUTION: This urea derivative expressed by general formula (1) [wherein, at least one of R<SB>1</SB>to R<SB>4</SB>is a substituent expressed by general formula (2):-(CH<SB>2</SB>)<SB>n</SB>-O-R<SB>5</SB>(2) (wherein, (n) is an integer of 2 or 3; and R<SB>5</SB>is 1-4C alkyl or 2-4C hydroxyalkyl); and others are each H] is used. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

（Ｒ１、Ｒ２、Ｒ３およびＲ４の少なくとも１つは下記一般式（２）で表される置換基を表し、残りは水素原子を表す。）

（ｎは２または３の整数を表し、Ｒ５は炭素数１〜４のアルキル基または炭素数２〜４のヒドロキシアルキル基を表す。） The present invention relates to a cosmetic or skin external preparation characterized by containing a urea derivative represented by the general formula (1).

(At least one of R1, R2, R3 and R4 represents a substituent represented by the following general formula (2), and the rest represents a hydrogen atom.)

(N represents an integer of 2 or 3, and R5 represents an alkyl group having 1 to 4 carbon atoms or a hydroxyalkyl group having 2 to 4 carbon atoms.)

Moisturizing damaged hair in daily life such as perm, bleach, hair color, ultraviolet light, heat, brushing, etc. is important to prevent the damaged hair from drying out and to restore the original healthy hair. As cosmetics that moisturize hair, it is known to use urea with high moisture retention. However, since urea decomposes in the presence of water and the moisturizing function of urea decreases, it has been difficult to use urea in the presence of water. Therefore, hydroxyalkylurea such as hydroxyethylurea has been proposed as a urea derivative that has good stability to water and maintains the moisture retention of urea (Patent Document 1). Further, hydroxyethylurea has been confirmed to have an effect of improving damaged hair, such as an effect of improving hair tensile strength and an effect of improving the crystallinity of hair (Patent Document 2).
JP 2006-96725 A JP2007-91615

  However, although hydroxyalkylurea has improved stability to water as compared with urea, it has not always been sufficient. That is, when it was used as an aqueous solution, there was a problem that the pH changed greatly with time, and the stability over time of cosmetics or skin external preparations was adversely affected. Further, hydroxyethylurea has a defect that it decomposes when stored in air for a long period of time, and the stability over time is not satisfactory. Against this background, there has been a demand for a urea derivative that has excellent stability over time, pH stability of an aqueous solution, an excellent improvement effect on damaged hair, and a high moisturizing effect.

  The problem to be solved by the present invention is a urea derivative having excellent stability over time, pH stability of an aqueous solution, excellent improvement effect on damaged hair, and high moisturizing effect, and contains the urea derivative It is to provide a cosmetic or an external preparation for skin.

（Ｒ１、Ｒ２、Ｒ３およびＲ４の少なくとも１つは下記一般式（２）で表される置換基を表し、残りは水素原子を表す。）

（ｎは２または３の整数を表し、Ｒ５は炭素数１〜４のアルキル基または炭素数２〜４のヒドロキシアルキル基を表す。） As a result of intensive studies to solve the above problems, the present inventors have found that the above problems can be solved by using a urea derivative represented by the following general formula (1), and have completed the present invention. . That is, this invention provides the cosmetics and skin external preparation containing the urea derivative represented by General formula (1).

(At least one of R1, R2, R3 and R4 represents a substituent represented by the following general formula (2), and the rest represents a hydrogen atom.)

(N represents an integer of 2 or 3, and R5 represents an alkyl group having 1 to 4 carbon atoms or a hydroxyalkyl group having 2 to 4 carbon atoms.)

  The urea derivative of the present invention is excellent in stability over time and pH stability of an aqueous solution, is also smooth to the touch, has no moist and sticky feeling, is well-familiar to the skin, and is a makeup using water as a medium. It can be preferably blended into the skin preparation and the external preparation for skin. Further, by blending the urea derivative of the present invention, it is possible to obtain a cosmetic or external preparation for skin that exhibits an excellent improvement effect on damaged hair, has a high moisturizing effect, and is excellent in safety such as skin irritation. it can.

（Ｒ１、Ｒ２、Ｒ３およびＲ４の少なくとも１つは下記一般式（２）で表される置換基を表し、残りは水素原子を表す。）

（ｎは２または３の整数を表し、Ｒ５は炭素数１〜４のアルキル基または炭素数２〜４のヒドロキシアルキル基を表す。） In order to develop the excellent function of the present invention, it is essential to use a urea derivative represented by the following general formula (1).

(At least one of R1, R2, R3 and R4 represents a substituent represented by the following general formula (2), and the rest represents a hydrogen atom.)

(N represents an integer of 2 or 3, and R5 represents an alkyl group having 1 to 4 carbon atoms or a hydroxyalkyl group having 2 to 4 carbon atoms.)

  As the urea derivative represented by the general formula (1) used in the present invention, at least one of R1, R2, R3 and R4 represents a substituent represented by the general formula (2), and the rest represents a hydrogen atom. Preferably, only R1 is substituted. In the substituent represented by the general formula (2), n represents an integer of 2 or 3, and R5 represents an alkyl group having 1 to 4 carbon atoms or a hydroxyalkyl group having 2 to 4 carbon atoms. Examples include methyl group, ethyl group, propyl group, isopropyl group, butyl group, t-butyl group, 2-hydroxyethyl group, 3-hydroxypropyl group, 4-hydroxybutyl group and the like. Specific examples of preferred urea derivatives represented by the general formula (1) used in the present invention include N- [2- (2-hydroxyethoxy) ethyl] urea, N, N′-bis [2- ( 2-hydroxyethoxy) ethyl] urea, N- (2-ethoxyethyl) urea, N, N′-bis (2-ethoxyethyl) urea, N- (3-methoxypropyl) urea, N, N′-bis ( 3-methoxypropyl) urea, N- (3-butoxypropyl) urea, N, N′-bis (3-butoxypropyl) urea, N- (3-t-butoxypropyl) urea, N, N′-bis ( 3-t-butoxypropyl) urea, N- (3-isopropoxypropyl) urea, N, N′-bis (3-isopropoxypropyl) urea, and more preferably N- [2- (2-hydroxy Ethoxy) ethyl] urea, N- (3 -Methoxypropyl) urea, N- (3-t-butoxypropyl) urea, N- (3-isopropoxypropyl) urea, N- (2-ethoxyethyl) urea, most preferably N- [2- ( 2-hydroxyethoxy) ethyl].

  Although the manufacturing method of the urea derivative used for this invention is not specifically limited, It manufactures by making the urea of a raw material, and hydroxyalkoxyalkylamine or alkoxyalkylamine heat-react at 90-110 degreeC without a solvent in the following manufacturing methods. it can. After completion of the reaction, it may be used as it is unpurified or may be further purified by a usual purification method such as vacuum distillation or steam deodorization. The feed ratio of hydroxyalkoxyalkylamine or alkoxyalkylamine to urea is 0.5 to 5 mol, preferably 0.8 to 2.5 mol, more preferably 0.9 to 1.5 mol, per mol of urea. It is good to make it about.

  The urea derivative represented by the general formula (1) thus obtained is excellent in stability over time, pH stability of an aqueous solution, is also smooth in touch, is moist and does not feel sticky, and is good for skin. Familiarity is good, and it can be preferably blended in cosmetics and skin external preparations using water as a medium. Further, by blending the urea derivative of the present invention, it is possible to obtain a cosmetic or external preparation for skin that exhibits an excellent improvement effect on damaged hair, has a high moisturizing effect, and is excellent in safety such as skin irritation. it can. The blending amount of the urea derivative of the present invention into the cosmetic or external skin preparation is not particularly limited, but is preferably about 0.01 to 50% by weight, more preferably about 0.1 to 50% by weight. Moreover, it is preferable to adjust the pH of the cosmetic or skin external preparation containing the urea derivative of the present invention to about 3 to 9, more preferably about 5 to 9.

  The cosmetic or skin external preparation containing the urea derivative of the present invention contains, as necessary, additive components that are generally blended into the cosmetic or skin external preparation, for example, an oily base, a moisturizing agent, a feel improving agent, an interface. Activator, polymer, thickener / gelator, solvent, propellant, antioxidant, reducing agent, oxidizing agent, antibacterial agent, preservative, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt , UV absorbers, whitening agents, vitamins and their derivatives, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensation agents , Warming sensation agent, wound healing promoter, stimulus relaxation agent, analgesic agent, cell activator, plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid , Fragrances, pigments, colorants, dyes, pigments, water and the like can be blended.

  Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as cannic acid, anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts, etc. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Type hydrocarbons such as candelilla wax, carnauba wax, rice wax, wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Tropsch wax, polyethylene wax, waxes such as ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, cucumber oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cacao butter, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Fats and oils; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanoli Lanolins such as adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, Phospholipid derivatives such as partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytoster Sterols such as oleol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl) ), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N Acyl sarcosine alkyl esters such as lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phyto Sterol esters such as steryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / phytosterol complex, etc. Lipid complex: octyldodecyl myristate, hexyl decyl myristate, octyl dodecyl isostearate, cetyl paritate, octyl dodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, isononanoate Isotridecyl acid, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octeodecanoate Ludodecyl, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil, isopropyl myristate , Isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl octyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc. Monoalcohol carboxylic acid esters; cetyl lactate, diisostearyl malate, monoisostearyl Oxyacid esters such as acid hydrogenated castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, glyceryl tri (caprylic / capric), tri (caprylic / capric / myristin) Acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate , Neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrtetraoctanoate Chill, hydrogenated rosin pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearic acid di Glyceryl, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene glycol distearate) , Dineopentanoic acid 3-methyl-1,5-pentanediol, dineopentanoic acid 2,4-diethyl-1,5-pentane Polyhydric alcohol fatty acid esters such as ol; dimer dilinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (Phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, diisostearic dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl die Dimer acid or dimer diol derivative such as merlinoleyl ether; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), Lauri Acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide polyamide) Fatty acid alkanolamides such as fatty acid methylethanolamide (cocamidomethyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone , Diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) Polymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carvone Acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and poly-modified Ether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane-oxyalkylene copolymer Silicones such as body; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.

  As the humectant / feel improver, glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyols such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether, etc. (Eicosandioic acid / tetradecandioic acid) water-soluble esters such as polyglyceryl-10 and tetradecandioic acid polyglyceryl-10; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose Mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and maltosylation, Modified cyclodextrins such as hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen Sugars such as ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoitin sulfate, caroline sulfate, kerato sulfate, dermatan sulfate; white jellyfish extract, white jellyfish Fucoidan; Tuberose polysaccharide, naturally-occurring polysaccharide; Organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; Urea; 2-pyrrolidone-5-carboxylic acid and salts thereof such as sodium; Betaine (trimethylglycine) , Proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methio , Leucine, isoleucine, valine, tryptophan, histidine, taurine and other amino acids and their salts; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium hydrolyzed collagen, elastin Degraded peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soy proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein Protein peptides such as degraded peptides and acylated peptides and their derivatives; palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapep Acylated peptides such as tide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; Animal and plant extract components such as placenta extract, aerostin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, and melilot extract Preferred are ceramides such as natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, ceramide, and sugar-ceramide-containing extract.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine a low thing and a high thing of HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium phosphate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetraethanolamine tetraethanol; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene polyoxypropylene monobutyl ether, polyoxyethylene lanolin; Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut oil fatty acid, glyceryl mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamate glycerin, monostearate glycerin malate; Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De-MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trialkylammonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl lanolin sulfate Fatty acid amide-type quaternary ammonium salts such as aminopropylethyldimethylammonium fatty acid; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; Silicone-based cationic surfactants such as amino-modified silicone, cation-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone;
In amphoteric surfactants, N-alkyl-N, N-dimethylamino acid betaines such as laurylbetaine (lauryldimethylaminoacetic acid betaine); fatty acid amidoalkyl-N, N-dimethylamino acids such as cocamidopropylbetaine and lauramidopropylbetaine Betaines; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated Soy phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, Preferred are tragacanth gum, acrylic acid / alkyl methacrylate copolymer; and various silicone surfactants.

  Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropi Cellulose, carboxymethylcellulose and its salts such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinate corn starch and aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ether Polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer, etc. Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; Kurylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationic cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer such as 47, methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; Polyethyleneimine; Cationic polymer; Polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; Acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, Smoke-like silica (ultrafine silicic anhydride), aluminum magnesium silicate, magnesium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester It is mentioned as preferable.

  Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation flon; propellants such as LPG, dimethyl ether, carbon dioxide, and the like are preferable.

  Antioxidants include tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Preferred are sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride As mentioned. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

  Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diol; alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether (ethylhexyl glycerin); salicylic acid; sodium benzoate; isothiazoline derivatives such as methyl chloroisothiazolinone and methylisothiazolinone; Dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzoyl chloride Luconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol , Photosensitizers, antibacterial zeolite, and silver ion are preferable, but when used as an antibacterial agent or antiseptic agent for antiseptic purposes, phenoxyethanol; 1 from the viewpoint of safety of cosmetics or skin external preparations; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable. pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylation Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Is preferable. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid-based purple such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Line absorber: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Nameto, cinnamic acid UV absorbers such as ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-
Dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-
Methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl -Benzophenone ultraviolet absorbers such as benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone; 3- (4'-methylbenzylidene) -d, l- Camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t- Octylphenyl) benzotriazole; 2- (2′-hy Dioxy-5'-methylphenylbenzotriazole;dibenzalazine;dianisoylmethane; 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one; di- such as 4-t-butylmethoxydibenzoylmethane Benzoylmethane derivatives; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- (3,4-dimethoxyphenyl) -4, Hydantoin derivatives such as 4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphulsulfonic acid, drometrizol trisiloxane, anthranyl Methyl, rutin and its derivatives, oryzanol and derivatives thereof as preferred.

  Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid phosphate salts such as ascorbic acid, sodium ascorbate phosphate and magnesium ascorbate phosphate, ascorbic acid Ascorbic acid fatty acid esters such as tetraisopalmitic acid ester, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate Ascorbic acid derivatives such as kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylreso Shinoru, oil-soluble Kamomiraekisu, oil-soluble licorice extract, Nishikawa willow extract, be mentioned as saxifrage extract, and the like plant extracts are preferred.

  Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin Es such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Ascorbic acid fatty acid esters such as corobic acid tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable. Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and nicotinic acid tocopherol, acetic acid tocopherol and other derivatives, γ-oryzanol, nicotinic acid, nicotinic acid amide, nicotinic acid benzyl Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Preferable examples include flavonol derivatives, stigmasterol or stigmasteranol, its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like. Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; and coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Antioxidant / active oxygen scavengers; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; rutin and glycosides, etc. Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances such as menthol, camphor, cedrol, and derivatives thereof Preferred examples include capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins.

  Plant / animal / microbe extracts include iris extract, ashitaba extract, asunaro extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, orange extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolysis Luc, Cascon extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Kawara mugi extract, Oat extract, Calcade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Kiou extract, Cyprid extract, Quina extract, Cucumber extract, Kiri leaf extract, Guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, clara extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, mulberry extract, gentian extract, Gentian pepper extract, tea Extract, yeast extract, kokuboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, Cowberry extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Salmon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimosukeso Extract, jatoba extract, peonies extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, west river willow extract, horse chestnut extract, hawthorn extract, elderberry extract, yarrow extract , Mint extract, sage extract, mallow extract, nematode extract, essence extract, Sakuhakuhi extract, Diou extract, Dai Extract, peanut extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red snapper extract, red snapper extract, red spruce extract, red spruce extract, tomato Extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, Loquat extract, dandelion extract, burdock extract, bukkuri extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, peppermint extract, body extract, button extract, hop extract, squid extract, pine extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts such as an extract and a bitumen extract are preferred.

  Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor, and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

  As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, eugenol, oak moss, opoponax resinoid, orange oil, eugenol, auranthiol, galac solid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromilsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, Nellore, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian valsum, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthol, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural fragrances such as D-limonene, linalool, rilal, rireal, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances It is mentioned as preferred.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 , Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230 No. 1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, red 506, orange 201, orange 203, orange 204, orange 205, orange 206, orange 207, orange 401, orange 402, orange 403, yellow 201, yellow 202- No. 1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406 Legal dyes such as Yellow No. 407 and Yellow No. 5; Other acidic dyes such as Acid Red 14; Arianor Sienna Brown, Arianor Madder Red, Arianor
Basic dyes such as Steel Blue and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-
Nitro dyes such as phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (Bengara) and iron titanate; and γ-iron oxide Inorganic brown pigments; inorganic yellow pigments such as yellow iron oxide and ocher; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; chromium oxide and chromium hydroxide Inorganic green pigments such as cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil Pearl powder such as aluminum powder, copper powder, metal powder pigment such as gold; surface treatment inorganic and metal powder pigment; red 01, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404 Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green Organic pigments such as zirconium, barium or aluminum lakes such as No. 3 and Blue No. 1; surface-treated organic pigments; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, Naphthoquinones such as chlorophyll, curcumin, cochineal, shikonin, bixin, flavo Natural pigments and dyes such as amines, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylene Oxidative dye intermediates and couplers such as diamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; auto-oxidizing dyes such as indoline; Can be mentioned.

  Preferred examples of water include normal water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and clustered water.

  In addition to these, cosmetic raw material standards, blending ingredient standard by cosmetic varieties, Japan Cosmetic Industry Association ingredient display name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese pharmacopoeia, pharmaceutical additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as the ingredients described, in known combinations, blending ratios and blending amounts.

  As the types of cosmetics or skin external preparations containing the urea derivative of the present invention, skin external preparations such as hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, ointments and the like are preferable. Can be mentioned. The cosmetic / skin external preparation of the present invention can be produced according to a usual method.

  The cosmetic or skin external preparation containing the urea derivative of the present invention will be described in more detail. Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, hair color shampoos and rinses. Shampoos such as body shampoo; rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, Hair blow, split hair coat, hair oil, permanent wave agent, straight perm agent, oxidative hair dye, hair bleach, hair color pretreatment, hair color after treatment, perm plate Instruments, permanent after-treatments, hair manicure, and as hair growth agents are preferred.

  Basic cosmetics include soft lotion, astringent lotion, cleansing lotion, multi-layer lotion, etc .; emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions such as emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion; emollient cream, nutritional cream, nari Thing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Cream, sun makeup cream, suntan cream, hair removal cream, deodorant cream, shaving cream, keratin softening cream, etc .; gel such as moisture gel; essence such as moisturizing essence, whitening essence, UV protection essence; liposome Liposome cosmetics such as beauty essence and liposome lotion; Peel-off packs, powder packs, washing packs, oil packs, cleansing masks and other packs and masks; cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, cleansing oils , Cleansing mask, washing powder, face washing powder, etc .; cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap Soap can be mentioned as preferred.

  Examples of makeup cosmetics that may be preferably used include white powder, dusts, foundations, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment.

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfumes, fragrance powder, perfume soap, body lotion and bath oil.

  Body cosmetics such as body shampoos; deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks and other deodorant cosmetics; decoloring agents, hair removal / hair removal agents; bathing agents; insect repellents A repeller is preferred.

  Moreover, as a skin external preparation, it can be used with dosage forms, such as an ointment, a patch, a lotion agent, a liniment agent, and a liquid coating agent. It can also be used as an oral cosmetic such as toothpaste and mouthwash.

  The cosmetic or skin external preparation containing the urea derivative of the present invention includes oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type emulsified cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, kneaded cosmetics, sticky cosmetics, volatile oily cosmetics, powdery cosmetics, jelly cosmetics, gels Preferred examples include cosmetics, pasty cosmetics, emulsified polymer cosmetics, sheet cosmetics, mist cosmetics, and spray cosmetics.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.

Production Example 1 Synthesis of N- [2- (2-hydroxyethoxy) ethyl] urea In a 500 mL reactor equipped with a stirrer, thermometer and gas introduction tube, 120 g of urea (2.0 mol) and 210 g of aminoethoxyethanol (2 0.0 mol), heated to 90-110 ° C. while blowing nitrogen, and allowed to react for 24 hours. Subsequently, steam deodorization and dehydration were performed to obtain 279.3 g (yield 94%) of the target N- [2- (2-hydroxyethoxy) ethyl] urea. The obtained compound was a pale yellow viscous liquid.
Infrared absorption spectrum (ATR method, neat)
3320, 2870, 1650, 1460, 1330, 775 cm-1

Evaluation of stability over time With respect to the urea derivative of the present invention obtained in Production Example 1, the stability over time of the drug substance was evaluated. As a comparison object, hydroxyethylurea was used.
(Evaluation methods)
The raw materials of each urea derivative were stored in a constant temperature bath at 50 ° C. for 1 week, 2 weeks, and 4 weeks, and the quantitative value of the urea derivative was measured by liquid chromatography to evaluate the change of the quantitative value.
Measurement conditions Column: CAPCELL PAK C18 UG120 (manufactured by Shiseido Co., Ltd.)
Eluent: 10 mM sodium phosphate buffer (pH 5.7): methanol = 97: 3
Detector: Differential refractive index detector (RI)
Column temperature: 40 ° C
Flow rate: 1 mL / min
Injection volume: 1 μL
(result)
The results are shown in Table 1. As shown in Table 1, the urea derivative of the present invention was excellent in stability over time. On the other hand, the comparison target hydroxyethylurea was inferior in stability over time.

Evaluation of pH stability of aqueous solution The urea stability of the present invention obtained in Production Example 1 was evaluated for pH stability. As a comparison object, hydroxyethylurea was used.
(Evaluation methods)
A 10% aqueous solution of each urea derivative was prepared, and the pH was adjusted to 7 using a 10% phosphoric acid aqueous solution. It was stored for 1 week, 2 weeks and 4 weeks in a constant temperature bath at 50 ° C., and the pH of the aqueous solution was measured. A pH meter (Horiba Seisakusho) was used for the measurement.
(result)
The results are shown in Table 2. As shown in Table 2, the urea derivative of the present invention was excellent as a urea derivative for cosmetics or external preparations for skin without any problem in pH stability in an aqueous solution. On the other hand, the hydroxyethylurea to be compared was inferior in pH stability in an aqueous solution.

Moisturizing property and feel evaluation The urea derivative of the present invention obtained in Production Example 1 was evaluated for moisturizing property and feel. As a comparison object, hydroxyethylurea was used.
(Evaluation methods)
A 10% aqueous solution of each urea derivative was prepared, and the moisturizing property (moist feeling) and the feeling of use (no stickiness, feeling of familiarity to the skin) when applied to the skin were evaluated by the sensuality of 10 panelists.
(result)
The results are shown below. The urea derivative of the present invention is excellent as a urea derivative for cosmetics or external preparations for skin, excellent in moisture retention (moist feeling), no stickiness, and familiar to the skin. On the other hand, the hydroxyethylurea to be compared was inferior in moisture retention (moist feeling) and familiarity with the skin.

Moisturizing feeling Feeling of use Compound name (Moist feeling) (No stickiness) (Feeling to skin)
------------------------------------
Urea derivative of Production Example 1 ◎ ○ ◎
Hydroxyethylurea ○ ○ △
------------------------------------
◎: 8 or more out of 10 responded good ○: 6 or more out of 10 responded good △: 4 or more out of 10 responded good ×: Less than 4 out of 10 responded good

Example 1, Comparative Examples 1-2 Evaluation of hair cosmetic and hair damage improvement effect Using the urea derivative of the present invention obtained in Production Example 1, hair cosmetics having the composition shown in Table 3 were prepared by a conventional method. (Example 1). Moreover, the hair cosmetics of the composition of Table 3 were similarly prepared by the conventional method as a comparison object (Comparative Examples 1-2). Healthy black hair was subjected to permanent treatment once with a commercially available permanent wave treatment agent and twice with a commercially available two-component oxidized bleach agent to produce three bundles of 50 damaged hairs. These hair bundles were immersed in 50 g of each hair cosmetic composition of Example 1 and Comparative Examples 1 and 2, treated at 40 ° C. for 30 minutes, washed with water and dried. After leaving at room temperature of 25 ° C. and humidity of 45% for 39 hours, 20 hairs were collected and the hair breaking strength was measured with a pulling tester (Rheometer / Fudo Kogyo Co., Ltd.). The measurement results are shown in the lower part of Table 3 as relative strength when the hair strength of undamaged hair (normal hair) is taken as 100.
(result)
As shown in Table 3, the hair cosmetic containing the urea derivative of the present invention (Example 1) is a hair cosmetic not containing the urea derivative of the present invention (Comparative Example 1) and a hair cosmetic containing hydroxyethyl urea. It was confirmed that the hair breaking strength recovery effect was higher than that of the sample (Comparative Example 2). This confirmed that the urea derivative of the present invention has an excellent improvement effect on damaged hair.

Safety The irritation of the urea derivative of the present invention obtained in Production Example 1 was evaluated by a cytotoxicity test using rabbit corneal cells (SIRC) (an alternative test method for eye irritation).
(Evaluation methods)
SIRC was seeded in a 96-well plate in which sample solutions of various concentrations prepared in advance in MEM medium containing 10% calf serum (FBS) were dispensed. After leaving still at room temperature for 20 minutes, it was continuously cultured in a CO2 incubator for cells at 37 ° C. for 3 days. Three days later, a neutral red assay was performed, and TC50 (50% cytotoxic concentration) was calculated. Based on each TC50 value obtained, eye irritation was determined according to the criteria in line with the draft guidance “Guidelines for evaluating eye irritation of cosmetic ingredients using alternative methods” submitted to the Ministry of Health and Welfare in 1998. Sex determination was performed. The results are shown below.
(result)
The results are shown below. The following results show that the urea derivative of the present invention is excellent in safety.

Compound name Eye irritation -------------------------------
Urea derivative of Production Example 1 Unstimulated ---------------------------

Example 2 Shampoo A shampoo having the following formulation was prepared. This shampoo was able to give moist and smooth fingering to the hair.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 1.00
2 Cocamidopropyl betaine (30%) 30.00
3 Naureth sulfate Na (25%) 14.00
4 Nalauryl sulfate 1.00
5 Cocamide DEA 1.00
6 Methylparaben 0.20
7 Phenoxyethanol 0.80
8 Polyquaternium-10 0.60
9 Citric acid Appropriate amount 10 Water Amount to be 100 in total --------------------------------
(Preparation method)
No. 1 to 7 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 8, no. 10 was heated to about 70 ° C. and dissolved uniformly (part B). Part B was added to part A and mixed uniformly, and then cooled. Furthermore, no. 9 was added and mixed uniformly.

Example 3 Treatment A treatment having the following formulation was prepared. This treatment was able to give the hair a moist feeling and smooth fingering.

Component Blending amount (% by weight)
--------------------------------
1 Cetanol 8.00
2 Oleyl alcohol 1.00
3 Dimethicone (100cs) 1.00
4 Glyceryl stearate 1.00
5 Plandool-H (Nippon Seika) 1.00
6 Methylparaben 0.20
7 Behentrimonium chloride 2.40
8 Urea derivative of Production Example 1 1.00
9 Hydroxyethylcellulose 0.40
10 Citric acid Appropriate amount 11 Water A total amount of 100 --------------------------------
(Preparation method)
No. 1 to 8 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 9 to 11 were heated to about 70 ° C. and dissolved uniformly (part B). Part B was added to part A and stirred and mixed uniformly, and then cooled to room temperature.

Example 4 Conditioner A conditioner having the following formulation was prepared. This conditioner was able to impart moist and soft feeling to the hair.

Component Blending amount (% by weight)
--------------------------------
Part A Cetanol 7.00
Glycerin 8.00
Behentrimonium chloride (80%) 2.80
Glyceryl stearate 0.20
Dicocodimonium chloride 0.20
Urea derivative of Production Example 1 1.00
Part B Phenoxyethanol 0.40
Water Amount to be 100 in total Part C Citric acid Appropriate amount --------------------------------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A while stirring and mixed uniformly, and then cooled (part D). Add part C to part D and adjust the pH to 5.2-5.7.

Example 5 Facial cleansing foam A facial cleansing foam having the following formulation was prepared. This facial cleansing foam was capable of imparting a moist and smooth feeling to the skin.

Component Blending amount (% by weight)
--------------------------------
Palm fatty acid potassium (34%) 44.00
Cocamidopropyl betaine (30%) 38.00
Cocamide DEA 6.00
PEG1000 4.00
Genapol PMS 2.00
Methylparaben 0.20
Phenoxyethanol 0.20
Glycerin 4.40
Urea derivative of Production Example 1 1.00
Citric acid Appropriate amount Water Total amount of 100 --------------------------------
(Preparation method)
Mix all ingredients uniformly.

Example 6 Hair Cream A hair cream having the following formulation was prepared. This hair cream was not sticky, had good adhesion to the hair, and was excellent in set hair bundle feeling.

Component Blending amount (% by weight)
--------------------------------
Part A Cetanol 8.00
BEHENETH-2 2.00
BEHENETH-20 1.00
Methylparaben 0.20
Phenoxyethanol 0.40
Urea derivative of Production Example 1 2.00
Part B Polyquaternium-10 0.60
Ethanol (95%) 20.00
Citric acid Appropriate amount Water Total amount of 100 --------------------------------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A while stirring, and the mixture is uniformly mixed and then cooled.

Example 7 Hair Wax A hair wax having the following formulation was prepared. This hair wax was not sticky, had good adhesion to the hair, and was excellent in set hair bundle feeling.

Component Blending amount (% by weight)
--------------------------------
Part A Microcrystalline wax 12.00
Triethylhexanoin 5.00
Candelilla Row 6.00
Hydroxystearic acid 4.00
Glyceryl stearate (Rheidol MS-60) 1.00
Glyceryl stearate (MGS-BSE) 1.00
Behenez-2 4.00
BEHENETH-20 10.00
Phenoxyethanol 0.60
Methylparaben 0.20
BG 3.00
Urea derivative of Production Example 1 6.00
Part B Alcox Z-240 0.20
Water Amount to be 100 in total C Part KOH (10%) Appropriate amount -------------------------------
(Preparation method)
Take part A and part B, heat to about 80 ° C., and mix uniformly. The part B is gradually added to the part A while stirring and mixed uniformly, and then cooled (part D). Add part C to part D and adjust pH to 7.0-7.5.

Example 8 Lotion Toner lotion having the following formulation was prepared. This lotion was not sticky, gave a moist feeling, and was excellent in familiarity with the skin.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 BG 1.00
3 Glycerin 2.00
4 Citric acid 0.01
5 Na citrate 0.10
6 Arginine 0.10
7 Glycyrrhizic acid 2K 0.05
8 Ethanol 7.00
9 Preservative Appropriate amount 10 Perfume Small amount 11 Water Total amount to be 100 --------------------------------
(Preparation method)
No. 1-6 are No. 11 and stirred and mixed uniformly (part A). Next, no. 9 to 10 are No. No. 8 after dissolution in No. 8 7 was added and dispersed (part B). A part was added to part B with stirring to make it uniform.

Example 9 Tightening lotion (astringent lotion)
An astringent lotion having the following formulation was prepared. This lotion was not sticky and gave a moist and smooth feeling.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 BG 2.00
3 Glycerin 0.04
4 Lactic acid 0.10
5 Lactic acid Na 0.05
6 Zinc phenol sulfonate 0.10
7 PEG-60 hydrogenated castor oil 0.50
8 Ethanol 15.00
9 Preservative Appropriate amount 10 Perfume Small amount 11 Water Total amount to be 100 --------------------------------
(Preparation method)
No. 1-7 are No. 11 and stirred and mixed uniformly (part A). Next, no. 9 to 10 are No. 8 (part B). A part was added to part B with stirring to make it uniform.

Example 10 Styling Gel A styling gel having the following formulation was prepared. When applied to hair, this styling gel was not sticky, did not move even when it was applied, and had high hair adhesion due to its high adhesion, and had excellent hairstyle durability.

Component Blending amount (% by weight)
--------------------------------
1 STRUCTURE 2001 (made by NSC Japan) 5.00
2 TEA (50%) 3.50
3 AMPHOMER SH30 (made by NSC Japan) 3.00
4 Ethanol (95%) 3.00
5 Methylisothiazolinone 0.01
6 Urea derivative of Production Example 1 2.00
7 Glycolic acid Appropriate amount 8 TEA Appropriate amount 9 Water Total amount to be 100 --------------------------------
(Preparation method)
No. No. 9 no. 6 was dissolved by heating. 2, no. 5 is dissolved (part A). No. in part A 1 is gradually added and mixed uniformly (part B). No. No. 3 4 and dissolved in part B cooled to 40 ° C. while mixing and dissolved uniformly. No. 7 or No. 8 adjust the pH to 7.0-7.5.

Example 11 Emollient Cream An emollient cream having the following formulation was prepared. This emollient cream was a cream excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 Hydrogenated palm oil 2.50
3 Behenyl alcohol 2.00
4 Dimethicone (10cs) 1.50
5 Glyceryl stearate 1.50
6 Stearyl alcohol 1.20
7 Stearic acid PG (SE) 1.00
8 PEG-60 glyceryl isostearate 1.00
9 Octyl methoxycinnamate 0.20
10 Ethylparaben 0.10
11 1,3-butylene glycol 6.00
12 Glycerin 1.00
13 Phenoxyethanol 0.20
14 Methylparaben 0.15
15 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 10 was added, and the mixture was heated to about 80 ° C. and dissolved (part A). No. in a separate container. 11 to 15 were taken, heated to about 80 ° C., and dissolved uniformly (part B). Part B was added to part A, emulsified with a homomixer, and then cooled to 40 ° C.

Example 12 Sunscreen Agent A sunscreen agent having the following formulation was prepared. This sunscreen agent was a cream that suppressed breakage due to sweat and had a moist feeling.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 11.70
2 Squalane 22.50
3 LUSPLAN PI-DA (Nippon Seika) 2.70
4 Microcrystalline wax 2.70
5 Distearate Al 1.60
6 Mg stearate 1.60
7 1,3-butylene glycol 5.00
8 Behenyl alcohol 4.80
9 Composite-PC (Nippon Seika) 1.00
10 Cholesterol 0.80
11 Propylparaben 0.10
12 Methylparaben 0.20
13 Titanium oxide 9.00
14 Mg sulfate 0.50
15 Water Total amount of 100 --------------------------------
(Preparation method)
No. No. 13 Nos. 1 and 2 3 was added and kneaded with a mill (part A). No. in a separate container. No. 2 4-6 were added and it heated and dissolved at about 150 degreeC (part B). No. in a separate container. No. 1 No. 7-12 was added, and it heated and dissolved at about 80 degreeC (C part). No. in a separate container. 14, 15 was added and heated to about 80 ° C. and dissolved (part D). Part C was added to part B, mixed, and then added to part A and mixed uniformly. Next, part D was added, stirred, and cooled to 40 ° C. after emulsification.

Example 13 Base Cream A base cream having the following formulation was prepared. This base cream was a base cream that had a good elongation, had a foundation, had a good feel, and was able to impart a light touch.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 5.00
2 Cyclomethicone 15.00
3 Trimethylsiloxysilicate 3.00
4 Glyceryl stearate (SE) 2.00
5 PG stearate (SE) 2.00
6 Macadamia nut fatty acid phytosteryl 2.00
7 Stearic acid 0.50
8 Palmitic acid 0.50
9 Octyl methoxycinnamate 0.50
10 Tocopherol 0.20
11 1,3-butylene glycol 10.00
12 Mica 8.00
13 Talc 7.00
14 Phenoxyethanol 0.80
15 Titanate (Li / Cobalt) 0.20
16 Xanthan gum (10%) 2.00
17 Cellulose gum (10%) 2.00
18 Wed 39.30
--------------------------------
(Preparation method)
No. 16 and 17 are No. It was dissolved in 18 to give a viscous liquid (2%) (part A). No. in a separate container. 1-10 was added, and it heated and dissolved at about 80 degreeC (B part). No. in a separate container. 11-15, no. The remainder of 18 was added and heated to about 80 ° C. and dissolved (part C). After adding part C to part B and emulsifying, part A was added and mixed uniformly. It cooled to 40 degreeC after stirring.

Example 14 Foundation A foundation having the following formulation was prepared. This foundation had excellent color development and a moist feel.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 6.00
2 Cyclomethicone 3.50
3 Dimethicone (5cs) 2.00
4 Trimethylsiloxysilicic acid 1.50
5 Octyl methoxycinnamate 1.00
6 Phenoxyethanol 0.40
7 Tocopherol 0.10
8 Mica 39.60
9 Talc 24.00
10 Titanium oxide 20.00
11 Iron oxide 1.90
--------------------------------
(Preparation method)
Each component was stirred at high speed and mixed uniformly.

Example 15 Lipstick A lipstick having the following formulation was prepared. This lipstick was fresh and highly adhesive.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 1.00
2 Cetyl octoate 22.50
3 Trioctanoin 28.50
4 Cyclomethicone 16.00
5 Ceresin 9.00
6 Candelilla Row 5.00
7 LUSPLAN PI-DA (Nippon Seika) 5.00
8 Sorbitan sesquiisostearate 4.00
9 Macadamia nut oil 1.00
10 Tocopherol 0.50
11 Iron oxide 2.25
12 Titanium oxide 2.25
13 Mica 1.50
14 Red 202 1.50
--------------------------------
(Preparation method)
No. Nos. 11-14 are No. 1 and 2 were kneaded (part A). No. in a separate container. 3 to 10 were added, and the mixture was heated to about 80 ° C. and dissolved (Part B). At about 80 ° C., part A was added to part B, dissolved, and then rapidly cooled.

Example 16 Lip Gloss A lip gloss having the following formulation was prepared. This lip gloss was fresh and had high adhesion.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 Dextrin palmitate 10.00
3 Macadamia nut oil fatty acid phytosteryl 43.00
4 Methylphenylpolysiloxane 30.00
5 Trioctanoin 10.00
6 Liquid paraffin 5.00
--------------------------------
(Preparation method)
No. 1 and 2 were heated to 100 to 110 ° C. and dissolved uniformly. Next, no. 3-6 were added and it was made to melt | dissolve uniformly at about 80 degreeC.

Example 17 Cleansing oil A cleansing oil having the following formulation was prepared. This cleansing oil had a refreshing feel and was well-familiar with foundations, makeup, etc., and could be quickly removed.

Component Blending amount (% by weight)
--------------------------------
1 Neosolue-Aculio (Nippon Seika) 1.00
2 Urea derivative of Production Example 1 1.00
3 Laureth-4 7.00
4 Tocopherol Appropriate amount 5 Propylparaben Appropriate amount 6 Cetyl octanoate Total amount of 100 7 Mineral oil 10.00
--------------------------------
(Preparation method)
All ingredients were heated and dissolved and mixed.

Example 18 Mascara A mascara having the following formulation was produced. This mascara had good adhesion, good usability, and good stability.

Component Blending amount (% by weight)
---------------------------------
1 Iron oxide (black) 10.00
2 Light isoparaffin 30.00
3 Polyacrylate emulsion 30.00
4 Solid paraffin 8.00
5 Urea derivative of Production Example 1 1.20
6 Sorbitan sesquioleate 4.00
7 Preservatives Appropriate amount 8 Perfume Appropriate amount 9 Water Amount that makes a total of 100 ---------------------------------
(Preparation method)
No. No. 9 no. No. 1 was added and dispersed with a homomixer. 3 was added and heated to 70 ° C. (aqueous phase). The other ingredients were mixed and heated to 70 ° C. (oil phase). The water phase was added to the oil phase, and the mixture was uniformly emulsified and dispersed with a homomixer to obtain the desired mascara.

Example 19 Eyeshadow An eye shadow having the following formulation was produced. This eye shadow had good adhesion, good usability, and good emulsification stability.

Component Blending amount (% by weight)
---------------------------------
1 Talc 10.00
2 Kaolin 2.00
3 facial 5.00
4 Urea derivative of Production Example 1 3.00
5 Stearic acid 3.00
6 Isopropyl myristate 5.00
7 Liquid paraffin 5.00
8 Propylene glycol monolaurate 3.00
9 Antioxidant appropriate amount 10 fragrance proper amount 11 1,3-butylene glycol 5.00
12 Glycerin 1.00
13 Preservative Appropriate amount 14 Triethanolamine 1.20
15 Metal ion sequestering agent Appropriate amount 16 Water Amount to be 100 in total ---------------------------------
(Preparation method)
No. 1-3 were mixed with a blender and then processed with a pulverizer (powder part). No. 11 to 16 were heated and dissolved at 70 to 75 ° C. (aqueous phase part). No. 4 to 10 were dissolved by heating at 70 to 80 ° C. (oil phase part). The powder part was added to the aqueous phase part and mixed with stirring. The oil phase was added to this while stirring, dispersed with a homomixer, and stirred and cooled to room temperature to obtain the desired eye shadow.

Example 20 Mild Shampoo A mild shampoo having the following formulation was prepared. This mild shampoo was a shampoo capable of imparting a moist feeling to the hair and providing smooth fingering.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Cocoyl methyl methyl taurine Na (30%) 30.00
3 Cocamidopropyl betaine (30%) 20.00
4 Laureth-12 Na acetate (30%) 5.00
5 1,3-butylene glycol 1.00
6 Cocamide MEA 2.00
7 Glycol distearate 1.50
8 Polyquaternium-10 0.50
9 Polyquaternium-7 0.30
10 Cationic NH (Nippon Seika) 0.50
11 Sodium benzoate 0.40
12 Phenoxyethanol 0.20
13 Methylparaben 0.20
14 Citric acid Appropriate amount 15 Water Amount to be 100 in total --------------------------------
(Preparation method)
No. 1 to 7 were heated to about 80 ° C. and dissolved (part A). No. in a separate container. 8 to 15 were heated to about 80 ° C. and dissolved (Part B). While stirring Part B into Part A, it was gradually added and mixed uniformly, and then rapidly cooled.

Example 21 Moistrin The following formula was prepared. This moisturizing was a non-sticky rinse that gave the hair a moist feeling and a smooth fingering.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.10
2 Plandool-H (Nippon Seika) 0.50
3 Cetrimonium chloride (30%) 5.20
4 Octild decanol 4.70
5 Cetanol 2.80
6 Stealtrimonium chloride (63%) 0.60
7 Cetyl octanoate 0.30
8 Squalane 0.30
9 Myristyl sulfate Na 0.20
10 ceteth-40 0.10
11 Ores-5 0.10
12 Nacetyl sulfate 0.10
13 Citric acid appropriate amount 14 Methylparaben 0.10
15 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 12 were heated to about 80 ° C. and dissolved (part A). No. in a separate container. 14 to 15 were heated to about 80 ° C. and dissolved (part B). While stirring Part B into Part A, gradually add and mix uniformly. After 13 was added and stirred, it was quenched.

Example 22 Straight Perm Agent (Cation Type)
One part and two parts of a straight perm agent (cation type) having the following formulation were prepared. This straight perm solution is a straight perm solution that can be applied firmly to the straight perm because of its high adhesiveness to the hair and setting power.

(1 liquid)
Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Cetanol 5.00
3 Stealtrimonium chloride (63%) 2.40
4 Seths-20 2.40
5 TRIBEHENIN PEG-20 ESTERS 2.00
6 Seths-6 0.80
7 Lauramide MIPA 0.80
8 PEG-60 hydrogenated castor oil 0.40
9 Ammonium thioglycolate (50%) 13.50
10 Monoethanolamine 1.70
11 Polyquaternium-6 1.30
12 Hydrolyzed soy protein 1.00
13 EDTA-4Na 0.10
14 Ammonia water (28%) 1.10
15 Water Total amount of 100 --------------------------------
(Preparation method)
No. Most of 15 were heated to about 80 ° C. (Part A). No. in a separate container. 1-8 were added and it heated and dissolved (part B). No. in a separate container. No.15, no. 9 to 13 were added and dissolved uniformly (part C). Part B was added to part A, mixed and stirred, and part C was added at about 45 ° C. and mixed uniformly. After cooling to room temperature, no. 14 was added.

(2 liquids)
Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 Cetanol 5.00
3 Emacol VT-20 (Sanei Chemical) 5.00
4 Dimethicone (200cs) 2.00
5 Trioctanoin 2.00
6 Octyldodecanol 0.60
7 Seths-20 0.50
8 Diammonium phosphate 0.20
9 Sodium benzoate 0.15
10 Na bromate 8.00
11 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1-7 were added, it heated at about 70 degreeC, and it was made to melt | dissolve (A part). No. in a separate container. No. 11 was taken and heated to about 70 ° C. 8 and 9 were added and dissolved (part B). No. in a separate container. No. 11 was taken and heated to about 60 ° C. 10 was added and dissolved (part C). At about 70 ° C., part B was added to part A and stirred until the viscosity increased. The mixture was cooled to 60 ° C., and part C was added with stirring and mixed uniformly. After the temperature dropped to about 50 ° C., it was rapidly cooled.

Example 23 Hair bleaching agent (2 agent type)
A hair bleaching agent (two-part formulation) having the following formulation was prepared. This depigmenting agent (two-component type) is a depigmenting agent that reduces the sense of hair damage after depigmentation and gives the hair a good feel such as flexibility, moistness, and slipping. there were.

(1 agent)
Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Polyoxyethylene oleyl ether 52.00
3 Ammonia water (25%) 25.50
4 Cetrimonium chloride (30%) 10.00
5 Ethanol 10.00
6 Water Total amount of 100 --------------------------------
(Preparation method)
Each component was stirred and mixed uniformly.

(2 agents)
Component Blending amount (% by weight)
--------------------------------
1 Hydrogen peroxide solution 17.00
2 Cetrimonium chloride (30%) 10.00
3 Cetanol 3.00
4 Seth-2 1.00
5 Seths-20 1.00
6 Na pyrophosphate 0.10
7 Diethylenetriaminepentaacetic acid 0.10
8 Citric acid Appropriate amount 9 Water Amount to be 100 in total --------------------------------
(Preparation method)
Each component was mixed uniformly, and the pH was adjusted to 3.5 to 4.0 with citric acid.
(Mixing ratio)
1 agent: 2 agents = 1: 7

Example 24 Oxidative hair dye An oxidative hair dye having the following formulation was prepared. This oxidative hair dye is an oxidative hair dye that can reduce the feeling of hair damage after hair dyeing and give the hair a good feel such as flexibility, moist feeling, and slipperiness. It was.

(1 agent)
Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Cetrinium chloride (25%) 24.00
3 Cetanol 9.00
4 Octild Decanol 9.00
5 Monoethanolamine 3.80
6 Ammonia water 2.00
7 Myristyl sulfate Na 1.50
8 Ores-20 1.40
9 Toluene-2,5-diamine hydrochloride 1.00
10 Resorcin 1.00
11 Metaaminophenol 0.50
12 Paraaminophenol 0.20
13 Orthoaminophenol 0.10
14 Ascorbic acid 0.20
15 Fragrance 0.10
16 Water Total amount of 100 --------------------------------
(Preparation method)
Each component was mixed uniformly.

(2 agents)
Component Blending amount (% by weight)
--------------------------------
1 Hydrogen peroxide solution 17.00
2 Cetrinium chloride (30%) 10.00
3 Cetanol 3.00
4 Seth-2 1.00
5 Seths-20 1.00
6 Na pyrophosphate 0.10
7 Diethylenetriaminepentaacetic acid 0.10
8 Citric acid Appropriate amount 9 Water Amount to be 100 in total --------------------------------
(Preparation method)
Each component was mixed uniformly, and the pH was adjusted to 3.5 to 4.0 with citric acid.
(Mixing ratio)
1 agent: 2 agents = 1: 1

Example 25 Curling Agent A curling agent having the following formulation was produced. By using the curl agent 1 and 2 produced in this way for the hair, it was possible to curl with good flexibility, slipperiness, moist texture, and good finish.

(1 liquid)
Component Blending amount (% by weight)
---------------------------------
1 Cysteamine hydrochloride 2.00
2 DL cysteine 0.40
3 Monoethanolamine 0.90
4 Ammonia water (28%) 0.50
5 POE20 palm oil fatty acid sorbitan 0.50
6 Fragrance 0.10
7 Diallylammonium chloride / acrylic acid copolymer 1.00
8 Emmacol VT-20 (Sanei Chemical) 3.00
9 Ores-20 0.50
10 Ores-50 0.20
11 Urea derivative of Production Example 1 0.50
12 Lanolin fatty acid octyldodecyl 0.30
13 Sorbitan monostearate 0.20
14 Edetate tetrasodium tetrahydrate 0.10
15 Ammonium phosphate 0.50
16 Water Total amount of 100 ---------------------------------
(Preparation method)
No. No. 16 in part (20%) 1 to 3 was added and dissolved, and No. 1 was previously stored in a separate container. No. 16 in part (10%) What was melt | dissolved by adding 14 and 15 was added at about 40 degreeC, and it was made to melt | dissolve uniformly (part A). In another container, no. The remainder of 16 was warmed to about 75 ° C. (Part B). In another container 8-13 were taken and heated to about 75 ° C. to dissolve (Part C). After adding part B to part C and emulsifying and stirring and mixing well, it was cooled to 40 ° C. and part A was added and stirred uniformly. Next, no. No. 7 was added and stirred. Nos. 5 and 6 were added. 4 was added, and the mixture was stirred and mixed uniformly to adjust the pH to 9.0 to 9.5 to obtain the target curling agent 1 solution.

(2 liquids)
Component Blending amount (% by weight)
----------------------------------
1 EDTA-2Na 0.10
2 Na bromate 4.00
3 Ammonium phosphate 0.50
4 Cationic NH (Nippon Seika) 2.00
5 Cetrinium chloride (30%) 1.00
6 Ores-50 0.20
7 Dimethicone Copolyol 0.50
8 Benzoic acid Na 0.15
9 Water Amount that totals 100 ----------------------------------
(Preparation method)
No. 4-7 were heated to about 80 ° C. and dissolved (part A). In another container 9 (70%) and No. 9 1 and 8 were added and heated to about 80 ° C. to dissolve (Part B). In another container, no. No. 9 and No. 9 A few were added and heated to about 50 ° C. to dissolve (Part C). Add part B to part A and mix and stir uniformly to emulsify, then add part C when the temperature reaches 40 ° C., mix well, and adjust the pH to 6.5 to 6.8 at room temperature. Curl agent 2 liquid was obtained.

Example 26 Pasty lipstick A pasty lipstick having the following formulation was prepared. This lipstick was excellent in terms of gloss and odor, and had a smooth and sticky feeling when applied.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 12-Hydroxystearic acid 8.00
3 Liquid paraffin A total of 100 4 Trioctanoin 30.00
5 Silicic anhydride 0.30
(Aerosil R974 manufactured by Nippon Aerosil Co., Ltd.)
6 Red 202 No. 7 Appropriate 7 Yellow No. 4 Appropriate --------------------------------
(Preparation method)
No. 1-7 are heated and mixed uniformly.

Example 27 Solid powder foundation A solid powder foundation having the following formulation was prepared. This solid powder foundation was excellent in feeling of use, adhesion to the skin, persistence of makeup, smell and the like.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 10.00
2 Perfluoropolyether 5.00
3 Silicone-treated sericite 60.00
4 Titanium oxide 10.00
5 Powdered synthetic hydrocarbon wax 1.00
6 Yellow iron oxide 1.00
7 Bengala 0.50
8 Methylparaben 0.50
9 Black iron oxide 0.05
19 Talc Total amount of 100 --------------------------------
(Preparation method)
No. Add 1-2, warm to about 70 ° C. and mix (Part A). No. in a separate container. 3 to 10 are mixed and dispersed (part B). Add part A to part B and mix evenly.

Example 28 Hair Cream A hair cream having the following formulation was prepared. This hair cream was glossy, non-sticky, kept the moisture of the hair, and was able to give a smooth feel.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 Cetanol 4.00
3 Dimethicone (500cs) 13.00
4 Glyceryl stearate 2.80
5 Ores-10 phosphate 0.80
6 Glyceryl stearate (SE) 1.60
7 Phenoxyethanol 0.40
8 Methylparaben 0.20
9 10% NaOH 0.60
10 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 6 were heated to about 80 ° C and dissolved (part A). No. in a separate container. 7-10 was added, and it heated and melt | dissolved at about 80 degreeC (B part). Part B was added to part A and mixed with stirring.

Example 29 Rinse-in shampoo A rinse-in shampoo having the following formulation was prepared. This rinse-in shampoo imparts a moist feeling to the hair and can provide smooth fingering.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 1.00
2 Cocamidopropyl betaine (30%) 20.00
3 Lauryl sulfate TEA (40%) 15.00
4 Cocamide DEA 2.00
5 Cocoa glutamate TEA (30%) 30.00
6 Ethylene glycol distearate 1.20
7 Polyquaternium-10 1.60
8 Stearyl trimonium bromide (70%) 0.60
9 Phenoxyethanol 0.20
10 Methylparaben 0.20
11 Sodium benzoate 0.40
12 Citric acid Appropriate amount 13 Water A total amount of 100 --------------------------------
(Preparation method)
No. 7, 8, and 13 were heated to about 80 degreeC, and were stirred and mixed. Next, no. 3 is added and mixed. Add 1, 2, 4 to 6 and stir until uniform. 9-12 were added and dissolved.

Example 30 Emollient cream An emollient cream having the following formulation was prepared. This emollient cream was a cream excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 1.00
2 Cetyl octanoate 5.00
3 PEG-60 glyceryl isostearate 1.50
4 Hydrogenated palm oil 14.00
5 Ethylparaben 0.20
6 Stearyl alcohol 3.50
7 Glyceryl stearate (SE) 1.00
8 Steerless-6 1.50
9 PEG-8 distearate 1.00
10 Cetanol 3.00
11 Cetyl palmitate 2.00
12 Isocetyl myristate 5.00
13 Cetyl Dimethicone Copolyol 0.50
14 Tocopherol 0.20
15 Dimethicone (10cs) 1.00
16 Glycerin 4.00
17 Methylparaben 0.20
18 1,3-butylene glycol 6.00
19 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 15 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 16-19 were heated to about 70 ° C. and dissolved uniformly (part B). To Part A, Part B was added with stirring and emulsified, and then cooled.

Example 31 Massage Cream A massage cream having the following formulation was prepared. This massage cream was a cream having a high massage effect and excellent moisturizing effect.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 4.00
2 Macadamia nut fatty acid phytosteryl 8.00
3 Glyceryl stearate (SE) 2.00
4 Polysorbate 60 1.80
5 Sorbitan stearate 1.00
6 Polyglyceryl stearate-10 0.50
7 Cholesterol 0.20
8 Dimethicone (10cs) 1.00
9 Myristyl alcohol 1.00
10 Stearic acid 1.00
11 Stearyl alcohol 0.50
12 Behenyl alcohol 0.50
13 Hydrogenated palm oil 9.00
14 Tocopherol 0.10
15 Isostearyl palmitate 2.00
16 Cetyl octanoate 15.00
17 Ethylparaben 0.20
18 Phenoxyethanol 0.20
19 Methylparaben 0.10
20 1,3-butylene glycol 10.00
21 Glycerin 3.00
22 Water Amount that totals 100 --------------------------------
(Preparation method)
No. 1 to 17 were heated to about 70 ° C. and dissolved uniformly (part A). Next, no. 18-22 was heated to about 70 ° C. and dissolved uniformly (part B). To Part A, Part B was added with stirring and emulsified, and then cooled.

Example 32 Emulsion An emulsion having the following formulation was prepared. This emulsion was excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.50
2 Sorbitan stearate 0.50
3 PEG-10 stearate 0.50
4 Polysorbate 60 0.50
5 Cetyl octanoate 3.70
6 Cetanol 1.20
7 Dimethicone (10cs) 1.00
8 Ethylparaben 0.10
9 1,3-butylene glycol 3.00
10 (Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10
1.00
11 Glycerin 1.00
12 Phenoxyethanol 0.20
13 Methylparaben 0.15
14 Citric acid 0.01
15 Na citrate 0.09
16 Xanthan gum 0.10
17 Carbomer 0.15
18 Hydroxide K 0.06
19 Water Total amount of 100 --------------------------------
(Preparation method)
No. 16 is a part of No.16. In addition to 19, the mixture was stirred to obtain a viscous liquid (Part A). No. 17 in some No. No. 19 and stirring, No. 19 18 was added to obtain a viscous liquid (Part B). Next, no. 1 to 8 were heated to about 70 ° C. and dissolved (part C). No. 9-15, the remaining No. 19 was heated to about 70 ° C. and dissolved (part D). Part D was added to part C with stirring and emulsified, then cooled to about 50 ° C., part A and part B were added and stirred until uniform.

Example 33 Liquid Foundation A liquid foundation having the following formulation was prepared. This liquid foundation was excellent in usability and adhesion to the skin.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 5.00
2 Glyceryl stearate (SE) 1.00
3 Stearic acid PG (SE) 1.00
4 Cetyl octanoate 6.00
5 Tocopherol 0.10
6 Propylparaben 0.10
7 Titanium oxide / iron oxide mixture 18.00
(Toyo Pigment Co., Ltd. FDP-W-007)
8 Mica 7.00
9 Trimethylsiloxysilicate 3.00
10 Cyclomethicone 7.00
11 Phenylmethicone 5.00
12 Cellulose gum 0.10
13 Xanthan gum 0.20
14 1,3-butylene glycol 5.00
15 Methylparaben 0.20
16 Water Total amount of 100 --------------------------------
(Preparation method)
No. 12 is a part of No. 12. 16 and stirred to give a viscous liquid (Part A). No. 13 for some No. 13 16 and stirred to give a viscous liquid (Part B). Next, no. 1 to 6 and 9 to 11 were added, and the mixture was heated to about 70 ° C. and dissolved (part C). No. 7, 8, 14, 15 and the remaining No. 16 was heated to about 70 ° C. and dissolved (part D). Part D was added to part C with stirring and emulsified, then cooled to about 50 ° C., part A and part B were added and stirred until uniform.

Example 34 Leave-on treatment A leave-on treatment (for hair) having the following formulation was prepared. This leave-on treatment (for hair) has a moist feel and can impart softness and slipperiness to the hair. Moreover, stability was also favorable.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Neosolu-Aculio (Japan Seika) 2.00
3 Diethyl sebacate 1.00
4 Myristyl alcohol 5.00
5 Behenyl alcohol 1.00
6 Oleyl alcohol 1.00
7 Dimethylpropylamide stearate 2.00
8 Cocoamphoacetate Na (30%) 2.00
9 Glyceryl stearate 0.40
10 Myristic acid 0.60
11 Phenoxyethanol 0.40
12 Lactic acid Appropriate amount 13 Water A total amount of 100 --------------------------------
(Preparation method)
No. 1 to 11 were heated to about 80 ° C. and dissolved (Part A). In another container 12, 13 were taken and heated to about 80 ° C. to dissolve (Part B). Part B was gradually added to part A and mixed uniformly.

Example 35 Hair Essence A hair essence having the following formulation was prepared. This hair essence was refreshing and non-sticky and could give the hair a soft and slippery feel.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Neosolu-Aculio (Japan Seika) 2.00
3 Diethyl sebacate 1.00
4 Cetanol 1.00
5 Stealtrimonium chloride (63%) 0.80
6 Dicocodimonium chloride (75%) 2.80
7 Tetraoleic acid Solves-60 1.00
8 PEG-40 hydrogenated castor oil 0.20
9 Methylparaben 0.10
10 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1 to 8 were heated to about 80 ° C. and dissolved (part A). In another container 9, 10 was taken and heated to about 80 ° C. to dissolve (Part B). Part B was gradually added to part A and mixed uniformly.

Example 36 Anti-aging cream An anti-aging cream having the following formulation was prepared. This cream had good elongation and was excellent in the effect of imparting a moist feeling.

Component Blending amount (% by weight)
----------------------------------
A
Urea derivative of Production Example 1 10.00
Cetyl octanoate 7.00
Batyl isostearate 2.00
PEG-60 glyceryl isostearate 1.50
Hydrogenated palm oil 3.70
Ceramide 2 0.10
Retinol 0.10
Oil-soluble chamomile extract 0.10
Ethylparaben 0.20
Stearyl alcohol 3.50
Glyceryl stearate (SE) 1.00
Steerless-6 1.50
Distearic acid PEG-8 1.00
Cetanol 1.00
Dimethicone 1.00
Cetyl dimethicone copolyol 0.50
Tocopherol 0.20
B
Nishi Healing Extract 0.05
C
Arbutin 0.50
Ascorbic acid 2-O-glucoside 0.50
EDTA-3Na 0.10
Polyglutamic acid (Ichimaru Falcos, Bio PGA solution) 0.10
(Eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10
1.00
Glycerin 4.00
Bisulfite Na 0.05
Methylparaben 0.10
Phenoxyethanol 0.10
BG 6.00
Hydroxide K Appropriate amount of water Total amount of 100 ----------------------------------
(Production method)
A was heated to about 80 ° C. and dissolved uniformly (part A). C was heated to about 80 ° C. and dissolved (part C). While stirring with a homomixer at about 80 ° C., part C was gradually added to part A, mixed uniformly after emulsification, cooled to about 40 ° C., B was added and mixed uniformly.

Example 37 Hair restorer A hair restorer having the following formulation was prepared. This hair restorer was able to prevent hair loss, dandruff and itching.

Component Blending amount (% by weight)
----------------------------------
Urea derivative of Production Example 1 0.05
Neosolu-Aculio (Nippon Seika) 1.00
Diethyl sebacate 0.45
Menthol 0.10
Pepper tincture 0.50
Assembly extract 2.00
Ethanol 30.00
Preservative Appropriate amount of perfume Appropriate amount PPG-6 Decyltetradeceth-30 0.30
Water Total amount of 100 ----------------------------------
(Production method)
Each component was stirred and mixed uniformly.

Example 38 Acid hair dye (hair manicure)
An acid hair dye having the following formulation was prepared. This acidic hair dye was an acidic hair dye capable of imparting a good feel such as flexibility and slipperiness to the hair by performing treatment on the hair.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 Neosole-Aculio (Nippon Seika) 5.00
3 Benzyl alcohol 8.00
4 Citric acid appropriate amount 5 Brown 201 0.13
6 Black 401 0.05
7 Water Amount that totals 100 --------------------------------
(Preparation method)
Each component was mixed uniformly.

Example 39 Perm Agent A perm agent having the following formulation was prepared. This permanent agent was a permanent agent that gave hair a feeling of slipping and softness by applying to the hair.

(1 liquid)
Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 1.00
2 Polyquaternium-22 2.00
3 Monoethanolamine 1.00
4 Ammonia water (28%) 1.00
5 PEG-50 hydrogenated castor oil 0.20
6 Ammonium bicarbonate 2.00
7 Phosphoric acid 2Na 0.50
8 Ammonium thioglycolate aqueous solution (50%) 11.50
9 Cysteine 1.50
10 EDTA-4Na 0.15
11 Hydroxide Na 0.25
12 Polyquaternium-10 0.10
13 Water Total amount of 100 --------------------------------
(Preparation method)
No. No. 13 in the majority of No. 13 11 is dissolved and then No. 11 is dissolved. No. 12 was added in small portions and dissolved. 8-10 were added and dissolved (part A). No. in a separate container. Take the rest of 13 6 and 7 were added, and it heated and dissolved (part B). No. in a separate container. 1-5 was added, it heated at about 50 degreeC, and it was made to melt | dissolve (part C). Part B was added to part A and mixed uniformly, then part C was gradually added and mixed uniformly.

(2 liquids)
Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Benzoic acid Na 0.20
3 Edetic acid 2Na 0.10
4 Diammonium phosphate 0.10
5 Emmacol TS-703 (Sanei Chemical) 2.00
6 Stearyl trimonium chloride (50%) 2.00
7 Na bromate 10.00
8 Emmacol NZ (Sanei Chemical) 4.00
9 Ores-20 3.00
10 Water Total amount of 100 --------------------------------
(Preparation method)
No. Take most of 10 and heat to about 60 ° C. No. 1 to 3 were added and dissolved. 4 was added and dissolved. Then No. No. 5 and 6 were added, and the mixture was heated and dissolved. 7-9 was added and made uniform. The remaining No. 10 was added, mixed uniformly and cooled.

Example 40 Sunscreen Cosmetic A sunscreen cosmetic having the following formulation was prepared. This sunscreen cosmetic did not float white and had a high UV protection effect.

Component Blending amount (% by weight)
--------------------------------
A
Quaternium-18 Hectorite 1.00
B
Cyclomethicone 13.70
Diphenyl dimethicone 7.00
Urea derivative of Production Example 1 2.00
Dimethicone copolyol 5.50
YOFCO MAS (Nippon Seika) 1.00
C
Silicone-treated fine particle titanium oxide 3.90
Silicone-treated zinc oxide 2.10
D
Stearic acid Al 0.70
Hydroxide Al 0.50
Isononyl isononanoate 2.50
Isodecyl neopentanoate 2.50
E
Trimethylsiloxysilicate 1.20
Dimethicone 0.80
Meticon 0.10
Stearyl glycyrrhetinate 0.02
Sorbitan sesquioleate 2.00
Tocopherol 0.02
F
Na chloride 1.00
Methylparaben 0.15
Water Total amount of 100 --------------------------------
(Production method)
Add A to B and stir. Further, C is added and dispersed using a roller mill. D is heated and melted and added to the mixture of A, B, and C, and E is further added to about 70 ° C. F is warmed and emulsified gradually with stirring into a mixture of A to E. Cool with stirring, stop stirring at 40-35 ° C. and let stand.

Example 41 Bath agent (bubble bath)
A bath preparation having the following formulation was prepared. This bath preparation has effects such as moisturizing skin and improving skin gloss.

Component Blending amount (% by weight)
--------------------------------
A
(C12, 13) Palace-3 sulfate Na 5.00
Cocamide DEA 2.00
Sulfosuccinic acid (C12-14) Palace-2Na 2.00
1,3-butylene glycol 2.00
Urea derivative of Production Example 1 1.00
PEG-20 glyceryl triisostearate 1.00
B
Citric acid 0.05
Sodium benzoate 0.20
Blue No.1 Trace yellow No.4 Trace C
Water Total amount of 100 --------------------------------
(Production method)
A is dissolved in a part of C to make it uniform. Add the remaining C and B and knead well.

Example 42 Liquid Face Wash A liquid face wash having the following formulation was prepared. This liquid cleanser was able to give the skin a moist and smooth slipperiness.

Component Blending amount (% by weight)
--------------------------------
1 Lauroyl sarcosine Na 12.00
2 Myristoyl methyl taurine Na 2.00
3 Isethionate Na 1.00
4 Polyglyceryl laurate-6 2.00
5 Cocamide DEA 2.00
6 Sorbitol 8.00
7 PEG-30 4.00
8 1,3-butylene glycol 8.00
9 Urea derivative of Production Example 1 2.00
10 Glycerin 5.00
11 Phenoxyethanol 0.80
12 (HEMA glucoside / ethyltrimonium methacrylate methacrylate)
Copolymer (10%) (Nippon Seika) 1.00
13 Water Total amount of 100 --------------------------------
(Production method)
No. 3 and 10 were heated to about 80 ° C. and dissolved (part A). No. in part A 1, 2, 4-9, 11-13 were added, heated to about 80 ° C. and uniformly dissolved, and then cooled.

Example 43 Body Shampoo A body shampoo having the following formulation was prepared. This body shampoo was able to give the skin a moist and smooth slipperiness.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 cetealess-60 myristyl glycol 2.00
3 DEA laurate (1: 1 type) 5.00
4 Propylparaben 0.10
5 Methylparaben 0.20
6 Potassium soap base solution 40.00
7 Lauroylmethylalanine Na (30%) 10.00
8 Lactic acid Appropriate amount 9 Water Total amount to be 100 --------------------------------
(Production method)
No. 1-No. 5 was heated at about 70 ° C. and mixed uniformly (part A).
No. No. 8 9 was dissolved in part (B part). While stirring, No. 6, no. 7, no. The remainder of 9 and part B were gradually added and mixed uniformly.

Example 44 Face Wash Liquid A face wash liquid having the following formulation was prepared. This face-washing liquid was able to impart a moist feeling and a smooth sliding feeling to the skin.

Component Blending amount (% by weight)
--------------------------------
Lipidure PMB (Japanese fat) 1.00
Urea derivative of Production Example 1 1.00
Dipotassium glycyrrhizinate 0.05
Palm oil fatty acid diethanolamide 4.00
N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine 1.50
Palm oil fatty acid amidopropyl betaine 8.10
N-coconut oil fatty acid acyl-DL-alanine triethanolamine 1.50
Preservative Appropriate amount Sodium monohydrogen phosphate anhydrous 1.00
Citric acid Appropriate amount of water Amount that makes up to 100 in total
(Production method)
Warm to 40-50 ° C. and stir to make uniform.

Example 45 Facial cleansing foam A facial cleansing foam having the following formulation was prepared. This facial cleansing foam was capable of imparting a moist and smooth slipperiness to the skin.

Component Blending amount (% by weight)
--------------------------------
1 (coconut fatty acid / hydrogenated beef tallow fatty acid) glutamic acid Na 20.00
2 1,3-Butylene glycol 14.00
3 Plandool-H (Nippon Seika) 1.00
4 PEG-8 5.00
5 PEG-30 10.00
6 Lauric acid diethanolamide 2.00
7 Propylparaben 0.10
8 Methylparaben 0.20
9 Lipidure PMB (Japanese fats and oils) 1.00
10 Crystalline cellulose 10.00
11 Urea derivative of Production Example 1 5.00
12 Tocopherol 0.20
13 Water Total amount of 100 --------------------------------
(Production method)
No. 1 to 8 and 11 are heated to about 80 ° C. and dissolved. No. after dissolution Add 12 and 13 and dissolve. While stirring at about 60 ° C., no. Add 9, 10 and cool to about 40 ° C.

Example 46 Soap A soap having the following formulation was prepared. This soap was able to give the skin a moist feeling and a smooth slipperiness.

Component Blending amount (% by weight)
--------------------------------
Soken base Amount to be 100 in total Lauric acid 5.00
1,3-butylene glycol 3.00
Urea derivative of Production Example 1 5.00
Plandool-H (Nippon Seika) 0.05
Titanium oxide 1.00
Etidronic acid 0.10
Edetate 0.10
Yellow No. 205 Trace ---------------------------------
(Production method)
All components are dissolved by heating to 80 ° C., cooled with stirring, poured into molds and left to stand.

Example 47 Face wash A face wash of the following formulation was prepared. This facial cleanser was able to give the skin a moist feeling and a smooth slipperiness.

Component Blending amount (% by weight)
--------------------------------
A
Urea derivative of Production Example 1 0.50
Plandool-H (Nippon Seika) 0.20
Jojoba oil 0.10
Squalane 0.10
Cocamide DEA 2.00
Lauramide DEA 3.00
Tocopherol 0.20
Propylparaben 0.10
B
Distearate glycol 1.00
Lauroylmethylalanine Na (30%) 10.00
Coconut fatty acid K, myristic acid K (40%) 40.00
BG 3.50
1,5-pentanediol 0.50
1,2-hexanediol 0.30
PEG-20 5.00
PEG-400 5.00
Citric acid appropriate amount Methylparaben 0.20
CETEARETH-60 myristyl glycol 2.00
Water Total amount of 100 --------------------------------
(Production method)
A was heated to about 80 ° C. and dissolved. B was heated to about 80 ° C. and dissolved. B was added to A with stirring and emulsified, and then cooled to about 40 ° C.

Example 48 Moisturizing lotion A moisturizing lotion having the following formulation was prepared. This moisturizing lotion was excellent in the feeling of use and moisturizing, kept the skin soft and fresh and smooth and moisturized, and these effects lasted for a long time.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 2.00
2 (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10 1.00
3 BG 1.00
4 Glycerin 2.00
5 Citric acid 0.01
6 Na citrate 0.10
7 Ubiquinone 0.03
8 IOTG (Japan Seika) 0.03
9 Solves-60 tetraoleate 0.12
10 PEG-60 hydrogenated castor oil 0.03
11 PEG-30 glyceryl isostearate 0.03
12 Methylparaben 0.20
13 Fragrance Trace 14 Ethanol 7.00
15 Water Total amount of 100 --------------------------------
(Preparation method)
No. 1-6 are No. 15 and stirred and mixed uniformly (part A). Next, no. Nos. 7 to 13 14 (part B). A part was added to part B with stirring to make it uniform.

Example 49 Body Soap A body soap having the following formulation was prepared. The body soap can give a moist and smooth feeling to the skin.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 0.50
2 Potassium soap base solution 40.00
3 Lauroylmethylalanine Na (30%) 10.00
4 Lauramide DEA 5.00
5 Ethylene glycol distearate 1.50
6 BG 5.00
7 Propylparaben 0.10
8 Methylparaben 0.20
9 Lactic acid Appropriate amount 10 Water A total amount of 100 --------------------------------
(Production method)
No. 1-No. 10 was dissolved by heating at about 80 ° C. and cooled with stirring.

Example 50 Styling Gel A styling gel having the following formulation was prepared. When applied to hair, this styling gel was not sticky, did not move even when it was applied, and had high hair adhesion due to its high adhesion, and had excellent hairstyle durability.

Component Blending amount (% by weight)
--------------------------------
1 Urea derivative of Production Example 1 1.00
2 Diethoxyethyl succinate 2.00
3 STRUCTURE 2001 (made by NSC Japan) 7.00
4 TEA (50%) 3.00
5 AMPHOMER SH-10 (made by NSC Japan) 3.00
6 Ethanol (95%) 1.00
7 Methylisothiazolinone 0.01
8 Glycolic acid Appropriate amount 9 TEA Appropriate amount 10 Water Total amount to be 100 --------------------------------
(Preparation method)
No. 1, no. 2, No. 7 and No. 10 are heated to about 60 ° C. and dissolved. Furthermore, no. 3 was added and dispersed, then No. 4 was added to increase the viscosity, and the mixture was cooled to 40 ° C. (Part A). No. 5, no. 6 is mixed uniformly, added to part A, and mixed uniformly. No. 8 or No. 9 to adjust the pH to 7.2-7.5.

Example 51 Hair Foam A hair foam having the following formulation was prepared. This hair foam has a good feeling of use and a natural setting property, and provides an improved feel such as imparting gloss and moisture to the hair.

Component Blending amount (% by weight)
--------------------------------
(Stock solution formulation)
A
Urea derivative of Production Example 1 2.00
Neosole-Aquilio (Nippon Seika) 2.00
Plandool-G (Nippon Seika) 3.00
Isopropyl palmitate 0.50
Isopropyl myristate 0.50
Cyclomethicone 0.40
Dimethicone 0.20
Aminopropyl dimethicone 0.20
Dimethicone polyol 0.20
B
Behentrimonium chloride 0.20
Laureth-2, -4, -9, -23 Appropriate amount Polyglyceryl oleate-2 0.20
Glycerin 3.00
C
(Acrylates / stearyl acrylate / ethylamine oxide methacrylate)
Copolymer (50%) 2.00
Fragrance 0.10
Ethanol 15.00
Phenoxyethanol Appropriate amount Methylparaben Appropriate amount Water Total amount of 100 (filling formula)
Stock solution 50.00
LPG 50.00
--------------------------------
(Preparation method)
Add A to B lysate and mix uniformly. C was added and mixed, and after filling this can into a can, gas was filled.

Example 52 Hair Spray A hair spray having the following formulation was prepared. This hair spray has a good feeling of use and setability, and gives an improved feel such as imparting gloss and moisture to the hair.

Component Blending amount (% by weight)
--------------------------------
(Stock solution formulation)
A
Urea derivative of Production Example 1 2.00
Neosole-Aquilio (Nippon Seika) 2.00
Plandool-G (Nippon Seika) 1.00
LUSPLAN DD-DA5 (Nippon Seika) 1.80
Hydrogenated rosin triglyceride 0.20
B
PEG hydrogenated castor oil 0.02
C
Fragrance 0.05
Ethanol (anhydrous) A total amount of 100 (filling formula)
Stock solution 55.00
LPG 45.00
--------------------------------
(Preparation method)
Add B to A. C was added and mixed, and after filling this can into a can, gas was filled.

Example 53 Hair mist Hair mist having the following formulation was prepared. This hair mist was non-sticky, had a light setting property, and was able to impart a good feel and smooth fingering to the hair.

Component Blending amount (% by weight)
--------------------------------
Urea derivative of Production Example 1 0.20
Neosole-Aquilio (Nippon Seika) 2.00
Plandool-H (Nippon Seika) 0.30
SUCRAPH AG-8 (Nippon Seika) 0.20
Dimethicone 0.20
Cetrimonium chloride (30%) 4.00
Ethanol 8.00
Water Total amount of 100 --------------------------------
(Preparation method)
Each component was stirred and mixed uniformly.

Example 54 Hand Cream A hand cream having the following formulation was prepared. This hand cream was non-sticky and water-repellent hand cream.

Component Blending amount (% by weight)
--------------------------------
1 Plandool-G (Nihon Seika) 0.30
2 Silwax S (Nippon Seika) 4.00
3 Hydrogenated lecithin 1.00
4 Behenyl alcohol 2.50
5 CIO (Japan Seika) 3.00
6 Urea derivative of Production Example 1 3.70
7 Propylparaben 0.10
8 Dimethicone 4.00
9 BG 5.00
10 Methylparaben 0.20
11 Xanthan gum (2% aqueous solution) 15.00
12 Water Amount that totals 100 --------------------------------
(Preparation method)
No. 2, no. No. 8 was dissolved and No. 8 was dissolved. 1, no. Add 4-7 and warm to about 70 ° C. (A). No. 11 No. Dissolve in part of 12 to obtain a viscous liquid (B). No. 3, no. 9, no. 10, no. Add the remainder of 12 and warm to about 70 ° C. to dissolve (C). C is added to A with stirring, and the mixture is stirred and mixed with a homomixer for about 3 minutes (D). Add B to D and mix evenly, then cool to about 40 ° C.

Example 55 Hair Color Shampoo A hair color shampoo having the following formulation was prepared. This shampoo for hair color suppresses discoloration of the hair color, and provides a touch improvement such as glossiness and moisturization and a lasting effect.

Component Blending amount (% by weight)
--------------------------------
1 (HEMA glucoside / ethyltrimonium methacrylate methacrylate)
Copolymer (10%) (Nippon Seika) 4.00
2 Cocoyl Methyl Taurine Na (30%) 15.00
3 Olefin (C14-16) sulfonic acid Na (36%) 13.00
4 Nacococoate acetate (30%) 8.00
5 PPG-12-PEG-50 Lanolin 2.50
6 Cocoyl glutamic acid (30%) 7.00
7 Polyquaternium-10 1.00
8 Lauramidopropylhydroxysultain / water 4.00
9 PEG-20 hydrogenated castor oil 2.00
10 Sunflower Ceramide (LABORATORIES SEROBIOLOGIQUES) 0.50
11 Proticute U Alpha (Ichimaru Falcos) 0.50
12 Etidronic acid 0.20
13 PG 0.20
14 Urea derivative of Production Example 1 0.05
15 Methylparaben 0.20
16 Phenoxyethanol 0.20
17 Water Amount when total amount is 100 --------------------------------
(Preparation method)
No. No. 17 After adding 7 and stirring, warm to about 80 ° C. to dissolve (A). In another container 13 is weighed and 14, no. No. 15 was added and blended. 6 is added and heated to about 80 ° C. to dissolve (B). B is added to A. 2-No. Add 5 in order and stir uniformly (C). In another container 1, no. 8-No. 10 is weighed and dissolved at about 80 ° C. (D). While heating to about 80 ° C., D was added to C, and the mixture was stirred and dissolved uniformly. 11, no. 12, no. After adding 16 and stirring well, it is cooled to room temperature and adjusted to pH 5.5 to 6.0.

Example 56 Pre-shave lotion A pre-shave lotion having the following formulation was prepared. This pre-shave lotion has the effect of making the skin smooth.

Component Blending amount (% by weight)
--------------------------------
A
Urea derivative of Production Example 1 0.10
Citric acid appropriate amount zinc phenol sulfonate 0.20
PEG-60 hydrogenated castor oil 0.10
Glycyrrhizic acid 2K 0.05
Water A total amount B of 100
Ethanol 30.00
Tocopherol 0.01
Methylparaben 0.15
--------------------------------
(Preparation method)
Both A and B are dissolved at room temperature, and B is gradually added to A with stirring to make it uniform.

Example 57 After Shave Lotion After shave lotion having the following formulation was prepared. This after-shave lotion has the effect of making the skin smooth.

Component Blending amount (% by weight)
--------------------------------
A
Urea derivative of Production Example 1 0.10
Malic acid appropriate amount Hyaluronic acid Na 0.01
Zinc phenol sulfonate 0.20
PEG-60 hydrogenated castor oil 0.20
Glycyrrhizic acid 2K 0.05
Vitamin B6 hydrochloride 0.10
Water A total amount B of 100
Ethanol 30.00
Tocopherol 0.01
Menthol 0.01
Methylparaben 0.15
--------------------------------
(Preparation method)
Both A and B are dissolved at room temperature, and B is gradually added to A with stirring to make it uniform.

Example 58 Carmine Lotion A carmine lotion having the following formulation was prepared. This carmine lotion has the effect of making the skin smooth.

Component Blending amount (% by weight)
--------------------------------
A
Calamine 0.40
Kaolin 4.00
Mg carbonate 0.10
Water 20.00
B
Urea derivative of Production Example 1 0.20
1,3-butylene glycol 2.00
Allantoin 0.10
Water amount C to be 100 in total
Ethanol 20.00
Canful 0.05
Methylparaben 0.20
--------------------------------
(Preparation method)
A is dispersed. Both B and C are dissolved at room temperature, C is gradually added to B with stirring, and A is gradually added with stirring to make uniform.

Example 59 Deodorant Lotion A deodorant lotion having the following formulation was prepared. This deodorant lotion has the effect of making the skin smooth.

Component Blending amount (% by weight)
--------------------------------
A
Amount of water totaling 100 (styrene / DVB) copolymer 0.20
Tea dry distillation solution 0.50
Benzalkonium chloride 0.05
Na chloride 0.10
Carboxymethyl chitin 0.02
B
Urea derivative of Production Example 1 0.10
Denatured alcohol 50.00
Methylparaben 0.20
--------------------------------
(Preparation method)
Both A and B are dissolved at room temperature, and B is gradually added to A with stirring to make it uniform.

Example 60 Deodorant (Antiperspirant)
A deodorant (antiperspirant) having the following formulation was prepared. This deodorant has the effect of making the skin smooth.

Component Blending amount (% by weight)
--------------------------------
A
Urea derivative of Production Example 1 0.20
Water Amount that totals 100 Methylparaben 0.10
Na chloride 0.01
Citric acid 0.05
Na citrate 0.05
Laureth-21 0.10
Benzalkonium chloride 0.05
Chlorhydroxyaluminum 0.20
B
Denatured alcohol 40.00
Propylparaben 0.10
Isopropyl methylphenol 0.50
--------------------------------
(Preparation method)
Both A and B are dissolved at room temperature, and B is gradually added to A with stirring to make it uniform.

Example 61 Cleansing Gel A cleansing gel having the following formulation was prepared. Since this cleansing gel is excellent in solubility, it can be easily removed such as foundation and make-up, and effects such as imparting a refreshing feel can be obtained.

Component Blending amount (% by weight)
--------------------------------
1 Neosolu-Aculio (Nippon Seika) 15.00
2 Urea derivative of Production Example 1 1.00
3 Plandool-H (Nippon Seika) 2.00
4 Bellpole DC-30 (Nippon Seika) 2.00
5 LUSPLAN DD-IS (Nippon Seika) 15.00
6 PEG-25 hydrogenated castor oil 20.00
7 Glycerin 16.00
8 BG 5.00
9 Water Amount that totals 100 --------------------------------
(Preparation method)
No. 1-No. 8 is weighed and dissolved by heating to about 80 ° C. (A). No. 9 is weighed and heated to about 80 ° C. (B). While stirring, gradually add B to A, and cool to 40 ° C. after emulsification.

Example 62 Moisture Pack A moisture pack having the following formulation was prepared. This moist chair pack enhances the moisturizing effect, softens the skin, gives a moist feeling, and provides an excellent cleaning action.

Component Blending amount (% by weight)
--------------------------------
A
Polyvinyl alcohol 13.00
1,3-butylene glycol 3.00
Alginic acid K 0.50
(Styrene / Vinylpyrrolidone) Copolymer 1.50
B
Plandool-G (Nippon Seika) 0.30
Urea derivative of Production Example 1 0.20
PCA Glyceres-25 isostearate-25 1.50
Denatured alcohol 8.00
PEG / PPG-5 / 30 copolymer 1.00
Ores-10 phosphate DEA 1.00
Glycyrrhizic acid 2K 0.05
Tocopherol 0.10
Methylparaben 0.20
Hyaluronic acid Na 0.05
Na chloride 0.30
Water Total amount of 100 --------------------------------
(Preparation method)
A is warmed and swollen at 50 ° C. Slowly add B to A with stirring and mix uniformly. Cool with stirring, stop stirring at 30-25 ° C. and let stand.

Example 63 Hair Lotion A hair lotion having the following formulation was prepared. By applying this hair lotion, the refreshing feeling of menthol was maintained and the scalp was kept healthy.

Component Blending amount (% by weight)
--------------------------------
Part A Urea derivative of Production Example 1 2.00
Neosole-Aquilio (Nippon Seika) 2.00
Menthol 0.05
Ethanol 50.0
Part B Pyridoxine HCl 0.1
Glycyrrhizic acid 2K 0.1
BG 3.0
Panthenol 2.0
Water Total amount of 100 --------------------------------
(Preparation method)
A part Each component is mixed (A part). B part Each component is mixed (B part). Add part B to part A and mix evenly.

Example 64 Preperm Liquid A preperm liquid having the following formulation was prepared. This pre-perm liquid can be applied to the hair before the permanent treatment, so that hair damage can be suppressed, the perm can be applied, and the holding can be improved.

Component Blending amount (% by weight)
--------------------------------
Urea derivative of Production Example 1 2.0
Cationic NH (Nippon Seika) 0.8
Hydrolyzed keratin aqueous solution (number average molecular weight 400, evaporation residue concentration 25%)
0.5
Caprylyl glucoside (50%) 1.0
PolySugaSil C-35P (Nippon Seika) 0.5
Citric acid appropriate amount Na citrate appropriate amount methylparaben 0.2
Water Total amount of 100 --------------------------------
(Preparation method)
Dissolve all ingredients uniformly.

Example 65 Skin Care Cream A skin care cream having the following formulation was prepared. This skin care cream was excellent in the permeability of active ingredients such as arbutin. Moreover, it was a soft touch cream and had a moist and smooth good touch.

Component Blending amount (% by weight)
--------------------------------
1 Neosole-Aculio (Nippon Seika) 2.0
2 Arbutin 3.0
3 Urea derivative of Production Example 1 2.0
4 Glycerin 3.0
5 Squalane 3.0
6 IOTG (Japan Seika) 3.0
7 Palm kernel oil 2.5
8 Glyceryl stearate 1.8
9 PEG-60 glyceryl isostearate 1.1
10 PG (SE) stearate 1.0
11 Stearyl alcohol 1.2
12 Behenyl alcohol 1.7
13 Tocopherol 0.1
14 Dimethicone 1.5
15 Ethylparaben 0.1
16 Methylparaben 0.15
17 Citric acid 0.01
18 Na citrate 0.09
19 EDTA-2Na 0.1
20 Water Amount that totals 100 --------------------------------
(Preparation method)
No. 1-2 and 16-20 are heated to about 80 ° C. and dissolved (part A). No. 3-No. 15 is heated to about 80 ° C. and dissolved (Part B). Add Part A with stirring to Part B, and stir at 80 ° C. for 5 minutes with a homomixer. Cool to room temperature with stirring.

  According to the present invention, urea derivatives having excellent stability over time, pH stability of aqueous solution, excellent improvement effect on damaged hair, high moisturizing effect, and excellent safety such as skin irritation, and the like Can be obtained.

Claims (4)

A cosmetic or external preparation for skin containing a urea derivative represented by the following general formula (1).

(At least one of R1, R2, R3 and R4 represents a substituent represented by the following general formula (2), and the rest represents a hydrogen atom.)

(N represents an integer of 2 or 3, and R5 represents an alkyl group having 1 to 4 carbon atoms or a hydroxyalkyl group having 2 to 4 carbon atoms.)   The cosmetic or skin external preparation according to claim 1, wherein R1 in the general formula (1) is a substituent represented by the general formula (2), and the remaining R2, R3, and R4 are hydrogen atoms.   The cosmetic or external preparation for skin according to claim 1 or 2, wherein, in the general formula (2), n = 2 and R5 is a hydroxyethyl group. The cosmetic according to any one of claims 1 to 3, wherein the cosmetic is for hair.