JP3126539B2 - Skin roughness improver - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention provides an excellent effect of improving rough skin.
And a skin roughness improving agent suitable for an external preparation for skin .

[0002]

2. Description of the Related Art Various agents are incorporated into skin external preparations, and the effect of preventing rough skin is one of the medicinal effects. ing. Conventionally, nucleic acids have been used to improve skin roughness, but their effects have not been sufficient yet and have not been sufficient to expect the effects. The inventors of the present invention have conducted intensive studies on a method for preventing roughening of nucleic acids and improving the roughening effect of the nucleic acids. As a result, 4-tert-butyl-4′-methoxydibenzoylmethane and ribonucleic acid, deoxyribonucleic acid and their salts It has been found that this object can be achieved by blending with one selected from the group, and the present invention has been completed.

[0003]

That is, the present invention provides a 4-te
rt-butyl-4'-methoxydibenzoylmethane is mixed with ribonucleic acid, deoxyribonucleic acid and one selected from the group of salts thereof, and the amount of ribonucleic acid, deoxyribonucleic acid and salts thereof is 0.005 to 0 0.5% by weight and 4% by weight of ribonucleic acid, deoxyribonucleic acid and their salts.
Amount of -tert- butyl-4'-methoxydibenzoylmethane is Ri 1-100 Baidea, vitamin E and / or its
The present invention provides a skin roughness improving agent not containing a derivative of

Hereinafter, the configuration of the present invention will be described in detail. 4-tert-butyl-4'-methoxydibenzoylmethane used in the present invention is known from JP-A-55-66535.

[0005] The nucleic acids used in the present invention are known substances, and as the salts thereof, salts composed of ribonucleic acid or deoxyribonucleic acid and inorganic bases or organic bases are applied. Preferably, ribonucleic acid or deoxyribonucleic acid is used. Sodium salt, potassium salt, particularly preferably lysine salt,
Arginine salt is applied.

In the present invention, the content of ribonucleic acid, deoxyribonucleic acid and their salts is 0.005 to 0.5% by weight.
More preferably, the content is 0.05 to 0.5% by weight. At less than 0.005% by weight, the effect is 4-tert-
It cannot be expected to mix butyl-4'-methoxydibenzoylmethane. Moreover, what it was up to 0.5% by weight, for skin roughness improvement effect can be exhibited sufficiently Naru effect in an amount of this degree, because there is no difference even beyond this amount effect. 4-tert-butyl-4 'for roughening agent
The amount of methoxydibenzoylmethane is 1 to 100 times the weight of nucleic acids. The synergistic effect of both substances is best exhibited within this range.

[0007] In addition to the above essential components, the skin roughness improving agent of the present invention may be used, if necessary, as long as the effects of the present invention are not impaired.
Contains various components used in cosmetics, pharmaceuticals, etc., ie, aqueous components, powder components, oils, surfactants, humectants, thickeners, preservatives, antioxidants, coloring materials, ultraviolet absorbers, drugs, etc. be able to.

[0008] The dosage form of the present invention is optional. For example, the dosage form may be a solubilizing system of a lotion, an emulsion such as an emulsion or cream, or an ointment or a dispersion powder product.

[0009]

Next, the present invention will be described with reference to Test Examples and Examples. Test Example 1 4-tert-butyl-4 'in a cream having the following formulation
0% by weight of methoxydibenzoylmethane, 5% by weight,
The nucleic acids 0 wt%, was tested for rough skin improving effect in the human body panel cream was changed to 0.5 wt%. That is, the skin surface morphology of a healthy female person (face) is replicated using a myristine resin replica method and observed with a microscope (17 ×). Using 30 people (rough skin panels) judged to have skin roughness evaluations 1 and 2 shown in Table 1 based on the state of the skin print and the peeling state of the stratum corneum, the composition is applied to the left and right half of the face and left for 1 hour outdoors. One week later, a replica was taken again, the condition of the skin was observed, and the skin was evaluated according to the criteria shown in Table 1.

[0010]

[Table 1]

Formulation A Cetanol 0.5% Vaseline 2.0 Squalane 7.0 Self-emulsifying glyceryl monostearate 2.5 POE Sorbitan stearate (20EO) 1.5 4-tert-butyl-4 ' -Methoxydibenzoylmethane 5.0 Jojoba oil 5.0 B Propylene glycol 5.0 Glycerin 5.0 Vegum 5.0 Potassium hydroxide 0.3 Nucleic acids 0-0.5 Water Residual process A (oil phase) and B (Aqueous phase) is heated to 70 ° C. and completely dissolved. Add A to B and emulsify with an emulsifier. The emulsifier was cooled using a heat exchanger to obtain a cream. Table 2 shows the results of evaluation of this cream according to the above evaluation method.

[0012]

[Table 2]

From these results, it was found that a facial part using a skin external preparation containing one or more nucleic acids and 4-tert-butyl-4′-methoxydibenzoylmethane was replaced with a facial part using another skin external preparation. Remarkably improved skin roughness compared to
Fruit was observed.

Example 1 Cream Formulation A Stearic acid 10.0% Stearyl alcohol 4.0 Butyl stearate 8.0 Stearic acid monoglycerin ester 2.0 4-tert-butyl-4'-methoxydibenzoylmethane 2.0 Perfume 0.4 Preservative appropriate amount B Propylene glycol 10.0 Glycerin 4.0 Potassium hydroxide 0.4 Ribonucleic acid 0.5 Trisodium edetate 0.05 Purified water Residue A (oil phase) and B (aqueous phase) Each was heated to 70 ° C. and completely dissolved to obtain a cream by a usual method. When the above evaluation test was performed using this as a sample, good results were obtained.

Example 2 Lipstick Formula Paraffin 10.0% Microcrystalline Wax 8.0 Vaseline 15.0 Liquid Paraffin Residue 2-octyldodecanol 19.5 Sodium Alginate 1.0 Calcium Sulfate 1.0 Red No. 104 (1) ) Aluminum lake 4.0 Titanium oxide 1.0 4-tert-Butyl-4'-methoxydibenzoylmethane 0.5 Deoxyribonucleic acid 0.2 Lipstick was obtained by the usual method. When the above evaluation test was performed using this as a sample, good results were obtained.

[0016]

As described above, it is clear that the skin roughness improving agent of the present invention significantly increases the skin roughness improving effect of nucleic acids.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A61K 7/48 A61K 7/00

Claims (1)

(57) [Claims] 1. A mixture of 4-tert-butyl-4'-methoxydibenzoylmethane with one selected from the group consisting of ribonucleic acid, deoxyribonucleic acid and salts thereof, and a mixture of ribonucleic acid, deoxyribonucleic acid and salts thereof. The amount is 0.005
0.5 wt%, and ribonucleic acid, the amount of 4-tert-butyl-4'-methoxydibenzoylmethane against deoxyribonucleic acid and salts thereof Ri 1-100 Baidea, bi-
Skin rough without Tamine E and / or its derivatives
Remedy .