JPH10273413A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation excellent in prevention and remedy of rough skin, having excellent moisturizing effect, producing no sticky feeling and inducing less papula, comedo, etc., by including arginine (salt) and scutellaria root extracts. SOLUTION: This composition is obtained by compounding (A) 0.005-10 wt.%, preferably, 0.01-5 wt.% of arginine (salt) (e.g. arginine hydrochloride), (B) 0.001-10 wt.%, preferably, 0.005-5 wt.% of scutellaria root extracts, and as necessary, (C) powdered component(s), oily component(s), higher alcohol(s), higher fatty acid(s), moisturizer(s), organic solvent(s), antimicrobial/antiseptic agent(s), amino acid(s) (alkaline metal salt, hydrochloride), organic acid(s), various medicines, natural extracts, color(s), surfactant(s), perfume(s), purified water, etc. The component B is a solution obtained by subjecting the root of Scutellaria calensis of the genus Scutellaria belonging to labiatae to extraction with a solvent (e.g. ethanol).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin. More specifically, the present invention relates to an external preparation for skin which is excellent in the effect of improving rough skin, moisturizing and glossing the skin, does not generate papules, vesicles, blisters, erythema and the like, and is excellent in safety.

[0002]

2. Description of the Related Art One of the purposes of skin external preparations in the fields of cosmetics, quasi-drugs and pharmaceuticals is to prevent and improve rough skin. In order to achieve this object, it has heretofore been practiced to incorporate in the external preparation for the skin various amino acids, proteins, various extracts, and various humectants such as polysaccharides, glycerin, sorbitol, and propylene glycol.

[0003]

However, skin external preparations containing amino acids, proteins and various extracts are not necessarily sufficient in preventing and improving skin roughness. In addition, a skin external preparation containing a polysaccharide precipitates when alcohol is used in combination, and a large amount of a skin external preparation containing glycerin, sorbitol, propylene glycol, chondroitin sulfate, etc. causes stickiness or a hot flash. There is a problem. Among them, glycerin, which is the most commonly used moisturizer, and dermal glycol, which contains propylene glycol, may cause skin troubles such as papules, blisters, blisters, and erythema when used in large amounts. In recent years it has become known.

[0004] The present inventors have conducted intensive studies in view of the above circumstances. As a result, when an external preparation for skin was combined with an extract of Ougon together with arginine and / or a salt thereof, the preparation was excellent not only in prevention and improvement of rough skin but also in improvement. It has a new finding that it has a moisturizing effect, does not have the sticky feeling seen when other polyhydric alcohols such as glycerin and sorbitol are blended, and has less occurrence of papules, face blisters, blisters, erythema etc. The present invention has been completed.

The present invention provides a novel external preparation for skin which is excellent in preventing and improving rough skin, has an excellent moisturizing effect, has no sticky feeling, and is less likely to cause papules, face blisters, blisters, erythema and the like. Its purpose.

[0006]

That is, the present invention provides a skin external preparation characterized by comprising one or more of arginine and / or a salt thereof and a pentagon extract. is there.

[0007] The present invention also relates to the above-mentioned arginine and / or
Alternatively, the present invention provides the above external preparation for skin, wherein the salt is contained in an amount of 0.005 to 10% by weight.

Further, the present invention provides the above-mentioned external preparation for skin, characterized in that the extract of the pentagon contains 0.001 to 10% by weight.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.
Arginine used in the present invention is a kind of basic amino acid, and as its salt, for example, arginine hydrochloride,
Arginine acetate, arginine phosphate, arginine glutamate, arginine aspartate and the like. In the present invention, arginine hydrochloride, arginine aspartate and the like are preferably used. In the present invention, one or more of these can be used in combination.

The amount of arginine and a salt thereof in the present invention is preferably 0.005 to 10% by weight, more preferably 0.01 to 5% by weight, in the external preparation for skin.
If it is less than 0.005% by weight, it is difficult to exert the effects of the present invention,
On the other hand, if the content exceeds 10% by weight, the effect cannot be expected to increase.

[0011] The pentagon extract used in the present invention is:
Scutellaria of the Lamiaceae (Labiatae) plant, Scutellaria spp.
aicalensis Georgi) extracted from the roots with ethanol or a mixture of ethanol and water. It is also possible to extract using a water-soluble solvent other than ethanol, for example, 1,3-butylene glycol, propylene glycol and the like. In the present invention, for example, commercially available products such as Ohgon Liquid SE (Ichimaru Falcos Co., Ltd.) can be used.

In the present invention, the amount of the extract of the pentagon is preferably 0.001 to 10% by weight, more preferably 0.005 to 5% by weight, based on the total amount of the external preparation, as the pentagon extract obtained by distilling the extraction solvent. is there. 0.001% by weight
If it is less than 10%, it is difficult to exert the effects of the present invention.
The effect cannot be expected to increase even if it is added in excess of.

The external preparation for skin of the present invention contains, in addition to the above essential components, components usually used in external preparations for skin such as cosmetics, quasi-drugs and pharmaceuticals, without impairing the objects and effects of the present invention. It can be blended within a qualitative and quantitative range and manufactured by a conventional method. These components include, for example, powder components such as titanium dioxide, iron oxide, mica, talc, and resin powder; avocado oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, evening primrose oil, castor oil, sunflower oil, tea seeds Oil, rice bran oil, jojoba oil, cocoa butter, coconut oil, squalene, squalane, tallow, mokuro, beeswax, candelilla wax, carnauba wax, whale wax, lanolin, silicone oil, liquid paraffin, ceresin, vaseline, polyoxyethylene (8 Mol) oils such as oleyl alcohol ether and glyceryl monooleate; higher alcohols such as caprylic alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol and phytosterol; capric acid, lauric acid, myristic acid, palmitic acid, sulfuric acid Alin acid, behenic acid, lanolin fatty acids, linoleic acid, higher fatty acids such as linolenic acid; p-aminobenzoic acid, homomenthyl -7N
UV absorbers such as acetyl allantranilate, butyl methoxy benzoyl methane, di-para methoxy cinnamate-glyceryl mono-2-ethylhexanoate, amino salicylate, octyl cinnamate, 2,4-dihydroxy benzophenone; polyethylene glycol, glycerin, Humectants such as sorbitol, kyrisitol, maltitol, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, chitosan; methylcellulose, ethylcellulose, gum arabic, polyvinyl alcohol, montmorillonite,
Thickeners such as laponite; organic solvents such as ethanol and 1,3-butylene glycol; butylhydroxytoluene;
Antioxidants such as tocopherol and phytic acid; antibacterial preservatives such as benzoic acid, salicylic acid, sorbic acid, dehydroacetic acid, alkyl esters of parahydroxybenzoic acid (ethylparaben, butylparaben, etc.), hexachlorophene; glycine, alanine, valine, leucine , Serine, threonine, phenylalanine, tyrosine, aspartic acid,
Amino acids such as asparagine, glutamine, taurine, histidine and the like, and alkali metal salts and hydrochlorides thereof; organic acids such as acyl sarcosine acid (eg, lauroyl sarcosine sodium), glutathione, citric acid, malic acid, tartaric acid, lactic acid; vitamin A and the like Derivatives, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 and derivatives thereof, vitamin B12 such as vitamin B12, vitamin B15 and derivatives thereof, ascorbic acid, ascorbic acid sulfate (salt), ascorbic acid Vitamin C such as phosphate ester (salt) and ascorbic acid dipalmitate
Vitamins such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin E nicotinate, vitamins D, vitamin H, pantothenic acid, pantethine, etc .; nicotinamide, benzyl nicotinate , Γ-oryzanol,
Allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol, thymol, inositol, saponins (saikosaponin, carrot saponin,
Hetimasaponin, muclodisaponin, etc.), pantothenylethyl ether, ethinylestradiol, arbutin, tranexanoic acid, cepharanthin, placenta extract, etc .;
Assembly, thyme, touki, spruce, perch, horsetail,
Natural extract of luffa, horse chestnut, saxifrage, arnica, lily, mugwort, peonies, aloe, gardenia, sawara etc. extracted with organic solvents, alcohols, polyhydric alcohols, water, aqueous alcohols, etc .; pigments; sorbitan monolaurate, monopalmitic acid Sorbitan, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyethylene glycol monooleate, polyoxyethylene alkyl ether,
Nonionic surfactants such as polyglycol diester, lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hydroxyaliphatic ether, alkylated polysaccharide, alkyl glucoside, sugar ester, etc .; stearyl trimethyl ammonium chloride, benzalkonium chloride, lauryl amine oxide, etc. Cationic surfactants such as sodium palmitate, sodium laurate, sodium lauryl sulfate, potassium lauryl sulfate, alkyl triethanolamine ether, funnel oil, linear dodecylbenzene sulfate, polyoxyethylene hydrogenated castor oil, maleic acid, acylmethyl taurine, etc. Anionic surfactants; amphoteric surfactants; fragrances;
Purified water or the like can be added.

The external preparation for skin of the present invention refers to those applied to the outer skin as cosmetics (including skin cosmetics and hair cosmetics), pharmaceuticals, quasi-drugs, etc., for example, ointments, creams, emulsions , Lotions, packs, bath preparations and the like which are conventionally used for external preparations for skin. The dosage form is also aqueous solution type, solubilization type, emulsification type, powder type, oil liquid type, dispersion type, gel type, ointment type, water-oil two-layer type, water-oil-
It can take a wide range of forms, such as a three-layer powder system.

[0015]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the technical scope of the present invention is not limited thereto. The compounding amount is% by weight. In addition,
In the following examples, a commercial product of gongon liquid SE (Ichimaru Falcos Co., Ltd.) was used as the pentagon extract.

Examples 1, 2, and 3 Comparative Examples 1, 2, and 3:
Lotion "A lotion having a formulation shown in the following" Table 1 "was produced by a conventional method, and evaluated for its moisturizing effect, skin roughness improving effect, and skin roughness improving effect.

[Table 1] ---------------------------------------------- -------------------------- Ingredients Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 ----- -------------------------------------------------- ----------------- Alkydinin 1-0.51--Alkydinine hydrochloride-10.5---Oucidine extract 0.1 0.1 0.1- 0.1 0.1 glycerin------1 Purified water residue residue residue residue residue residue residue ----------------------------- -------------------------------------------

"Moisturizing Effect: Measurement of Moisture Evaporation Rate" In order to evaluate the moisturizing effect, each lotion in Table 1 was used as a sample (test liquid), and the water evaporation rate was measured using this. That is, after dropping 10 μl of the test solution onto a 2.0 × 2.0 cm filter paper, the weight loss was measured every minute for 10 minutes, and the weight loss per minute was determined. <Determination method> ◎: Water evaporation rate 0.50 μg / min or less ○: Water evaporation rate 0.50 to 0.55 μg / min △: Water evaporation rate 0.55 to 0.60 μg / min ×: Water evaporation rate 60 μg / min or more The results are shown in Table 1.

"Effect of Preventing Roughness of Skin" The effect of preventing roughening of skin against the stimulus of sodium dodecyl sulfate release application was tested. That is, human upper arm inner skin was treated with a 3% aqueous solution of sodium dodecyl sulfate to make the skin rough.
Two hours later, 40 μl of the lotion shown in “Table 1” was open-applied. This was repeated for 5 days, and on the 6th day, the skin roughness was measured visually. <Skin roughness score> 1: Extensive drying, turning over, and strong erythema are observed 2: Drying, turning up, and moderate erythema of the stratum corneum are observed 3: Drying of the stratum corneum is observed but no turning is observed.
Weak erythema is observed. 4: No corneal layer drying and turning up, but some erythema is observed. 5: No corneal layer drying, turning up, and erythema are observed. The lower the score, the more severe the skin is, and the higher the score, the more beautiful the skin. Is shown. The determination of the effect of improving skin roughness was made based on the average value of a specialized panel (10 persons) based on the above scores. <Judgment of skin roughness prevention effect> A: Average score is 4.5 or more and 5 or less B: Average score is 3 or more and less than 4.5 C: Average score is 2 or more and less than 3 D: Average score is 1 or more and 2 Less than E: Average score is less than 1

"Effect of Improving Skin Roughness" The skin surface morphology of a healthy woman (face) was replicated using a replica method with a silicone resin and observed with a microscope (17 times). That is, 30 persons (rough panel) determined to be 1 or 2 in the rough skin evaluation based on the following criteria based on the following criteria from the state of the skin pattern and the peeled state of the stratum corneum were used, and left and right half of the face were subjected to Examples and Comparative Examples. The lotion was applied twice a day. Two weeks later, the replica was again taken, the condition of the skin was observed, and the evaluation was performed in the same manner as described above according to the following criteria. <Roughness score> 1: Skin groove and skin hills disappeared, and widespread turning of horny layer was observed. 2: Skin sulcus and skin hills were unclear, and horny layer turning was observed. 3: Skin grooves and skin hills were observed. However, it is flat. 4: The skin ridges and skins are sharp. 5: The skin sulcus and skins are clear and tidy. The lower the score, the more severe the skin, and the higher the score, the more beautiful the skin. The determination of the skin roughness improvement effect was made based on the average value of the test subjects based on the above scores. <Judgment of skin roughness improvement effect> A: 90% of the subjects gave a score of 4 or 5
Above ○: 75% of the subjects gave a score of 4 or 5
Not less than 90% △: 25% of the subjects gave a score of 4 or 5
Not less than 75% ×: 25% of the subjects gave a score of 4 or 5
Less than

The results of the above evaluation are shown in Table 2 below. This indicates that the examples of the present invention are superior to the comparative examples in the moisturizing effect and the effect of preventing and improving rough skin.

[Table 2] ---------------------------------------------- ------------------------ Evaluation test Example: 1 2 3 Comparative example: 1 2 3 ------------ -------------------------------------------------- -------- Moisturizing effect ○ ○ ○ △ △ × Skin roughness prevention effect A A A B BC Skin roughness improvement effect ○ ○ ○ △ △ × ---------------- -------------------------------------------------- ------

Example 4 Cream A. Stearic acid 10.0 Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Perfume 0.4 Ethyl paraben Suitable amount B. Augon extract 1.0 Arginine hydrochloride 2.0 Glycerin 4.0 Potassium hydroxide 0.4 Trisodium edetate 0.05 Purified water Residue The oil phase of A and the aqueous phase of B are each heated to 70 ° C and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Example 5 Cream A. Cetanol 6.0 Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 Polyoxyethylene (20) sorbitan monostearate 2.8 Fragrance 0.3 Parahydroxyanisole Appropriate butylparaben Appropriate B. Glycerin 10.0 pentagon extract 0.02 dipropylene glycol 4.0 arginine hydrochloride 1.0 trisodium edetate 0.01 purified water residue A cream was obtained according to Example 4.

Example 6 Emulsion A. Squalane 5.0 Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether 1.2 Fragrance 0.3 Ethyl paraben Suitable amount B. 1,3-butylene glycol 4.5 pentagon extract 1.5 arginine hydrochloride 2.0 ethanol 3.0 carboxyvinyl polymer 0.2 potassium hydroxide 0.1 sodium hexametaphosphate 0.05 purified water residue Heat the oil phase of A and the water phase of B to 70 ° C respectively. Dissolve completely. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled to obtain an emulsion.

“Example 7 Foundation” A. Cetanol 3.5 Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 Polyoxyethylene (60) hydrogenated castor oil 1.5 Polyoxyethylene (20) cetyl ether 1.0 Ethyl paraben Suitable amount Fragrance 0.3 B. Propylene glycol 10.0 Ogugon extract 0.1 Arginine hydrochloride 1.0 Compound powder 12.0 Trisodium edetate 0.2 Purified water Residue The oil phase of A and the aqueous phase of B are each heated to 70 ° C and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled to obtain a foundation.

Example 8 Toner A. Ethanol 5.0 polyoxyethylene oleyl alcohol ether 2.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 fragrance 0.05 B. 1,3-butylene glycol 9.5 arginine hydrochloride 3.0 pentagon extract 5.0 nicotinamide 0.3 glycerin 5.0 purified water Residue The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

“Example 9 pack” (1) polyvinyl alcohol 10.0 (2) glycerin 3.0 (3) ethanol (95%) 8.0 (4) pentagon extract 0.1 (5) arginine hydrochloride 0.5 (6) ethyl paraben 0.1 ( 7) Fragrance 0.1 (8) Purified water Residue Mix and dissolve (3) (6) (7) at room temperature, and mix (1) (2) and (4) (5)
(8) was mixed and dissolved at 80 ° C., followed by stirring and then allowed to cool to room temperature to obtain a pack. The skin external preparations of Examples 4 to 9 are all excellent in preventing and improving skin roughness, papules,
It was an external preparation for skin with excellent safety, which did not cause blisters, blisters, and erythema.

[0027]

According to the present invention, it is possible to provide a skin external preparation which is excellent in improving and preventing rough skin, has an excellent moisturizing effect, has no sticky feeling, and does not cause problems such as erythema.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 35/78 ADA A61K 35/78 ADAQ // A61K 7/025 7/025 31/195 31/195

Claims (3)

[Claims] 1. An external preparation for skin, comprising one or more of arginine and / or a salt thereof and a pentagon extract. 2. The external preparation for skin according to claim 1, wherein the arginine and / or a salt thereof is contained in an amount of 0.005 to 10% by weight. 3. The pentagon extract may be used in an amount of 0.001 to 10
The external preparation for skin according to claim 1 or 2, which is contained by weight%.