JPH07215838A - Skin external agent - Google Patents

Abstract

PURPOSE:To obtain a skin external agent having an excellent skin roughness- improving effect and an excellent touch and high in safety. CONSTITUTION:A skin external agent is compounded with erythritol, a plant galenical and a skin-covering component. The skin external agent contains especially one or more kinds of natural extracts extracted from Eriobotrya japonisaca, Prunus persica, Aloe arborescens, Panax ginseng, and Luffa cylindrica as the plant galenical. The skin external agent contains one or more kinds of fats and oils, a wax, a hydrocarbon or silicone oil, a fatty acid, a higher alcohol, an ester oil, a gum, a polymer having a mol.wt. of >=3000 and a clay mineral as the skin-covering ingredient.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation, and more particularly to a skin external preparation having a high skin roughening improving effect and a good feeling in use.

[0002]

BACKGROUND OF THE INVENTION A major purpose of external preparations for skin is to maintain a beautiful skin condition. In order to maintain a beautiful skin condition, it is important to prevent and improve skin roughness, smooth the skin's groove and crest, and smooth the turnover of epidermal cells. Creams and emulsions for replenishing the skin have been used, and various moisturizers and agents such as hydrocortisone have been blended.

[0003]

However, moisturizers such as polysaccharides cause precipitation in a formulation system containing a large amount of alcohol, and glycerin, sorbitol, propylene glycol, chondroitin sulfate and the like have a sticky or hot feeling when mixed in a large amount. In addition, amino acids such as DL-threonine have drawbacks such as coloring and odor. Furthermore, it has become known in recent years that glycerin and propylene glycol, which are the most widely used moisturizers, cause papules, pimples, erythema and the like when mixed in large amounts.

Although drugs such as hydrocortisone exert remarkable effects, side effects such as moon face and fragility of bones have been reported, and their use is limited. The present invention has been made in view of the above-mentioned problems of the prior art, and an object thereof is to provide an excellent preparation for preventing rough skin, having an improving effect, and having an excellent feeling in use, and having less skin trouble. To do.

[0005]

Means for Solving the Problems As a result of intensive studies for achieving the above-mentioned object, the present inventors have found that an external preparation for skin containing erythritol, a herbal medicine and a skin-covering ingredient is effective in preventing and improving skin roughness. It was found that the present invention is not only excellent, but also has less stickiness and the occurrence of papules, pimples, erythema and the like found in other polyhydric alcohols such as glycerin and sorbitol, and completed the present invention.

That is, the external preparation for skin according to claim 1 of the present invention is characterized in that erythritol, a herbal medicine and a skin-covering ingredient are blended. In addition, claim 2 of the present invention
The external preparation for skin according to claim 1, which is the external preparation for skin according to claim 1, is a loquat (Eriobotrya j) as a botanical herb.
aponica), peach (Prunus persica), aloe (Aloe ar)
borescens), Korean ginseng (Panax Ginseng), and luffa cylindrill (Luffa cylindrill).

Further, the external preparation for skin according to claim 3 of the present invention is the external preparation for skin according to claim 1 or 2, in which oils and fats, waxes, hydrocarbon-based or silicone-based oils, fatty acids, and Higher alcohol, ester oil,
It is characterized in that any one type or two or more types of gum substance, polymers having a molecular weight of 3000 or more and clay minerals are blended.

The structure of the present invention will be described in detail below. Erythritol used in the present invention is also called meso-erythritol, and is a sugar alcohol of 4 carbon sugars contained in lichens, basidiomycetes, fruits and the like in the natural world. The compounding amount of erythritol in the present invention is 0.1 to 30 in the total amount of the skin external preparation.
Weight% is preferable, and 1 to 20 weight% is more preferable. If it is less than 0.1% by weight, the effect of the present invention is not sufficiently exerted, and if it exceeds 30% by weight, the effect corresponding to the increase of the compounding amount cannot be expected.

In addition, as a herbal drug used in combination with erythritol in the present invention, loquat (Eriobotrya japonic
a), peach (Prunus persica), aloe (Aloe arboresc)
ens), ginseng (Panax Ginseng), loofah (Luff
a cylindrill) is preferred. For these herbal medicines, leaves for loquat, peach and aloe, roots for ginseng,
For loofah, it is preferable to use the above-ground part. Further, these botanical herbs may be blended in a pulverized form, but a natural extract and / or an extract extracted with an extraction solvent such as alcohol, polyhydric alcohol, other various organic solvents, water or aqueous alcohol may be used. It is preferable to add a purified product, and 1,3-butylene glycol is preferably used for loquat and peach, and ethanol is preferably used for aloe, ginseng, and loofah.

Among these herbal medicines in the present invention,
One kind or two or more kinds can be mixed. The blending amount of the botanical herb in the present invention is 0.1 to 2 in the total amount of the external preparation for skin.
0% by weight is preferable, and 1 to 10% by weight is more preferable.
Is. If it is less than 0.1% by weight, the effect of the present invention is not sufficiently exerted, and if it exceeds 20% by weight, skin trouble may occur and the skin condition may be deteriorated.

[0011] In the present invention, the skin-covering component may temporarily thicken as a pack specification when it is applied on the skin, but in general, it covers the skin surface in a thin film form, Expected to have the same effect as the above sebum, it prevents the skin from drying due to water evaporation, imparts flexibility and elasticity, and further prevents rough skin and improves the skin. For example,
Fats and oils, waxes, hydrocarbon-based or silicone-based oils, fatty acids, higher alcohols, ester oils, gums, polymers or clay minerals, and the like, specifically, avocado oil, corn oil, olive oil, Rapeseed oil, evening primrose oil, castor oil, sunflower oil, tea seed oil, rice bran oil, jojoba oil, cacao oil, coconut oil, squalene, squalane,
Beef tallow, owl, beeswax, candelilla wax, carnauba wax, whale wax, lanolin, silicone oil, liquid paraffin, ceresin, vaseline, polyoxyethylene (8 mol) oleyl alcohol ether, glyceryl monooleate, etc., capryl alcohol, lauryl Alcohol, higher alcohols such as myristyl alcohol and cetyl alcohol, sterols such as cholesterol and phytosterol, capric acid, lauric acid, myristic acid,
Higher fatty acids such as palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid and linolenic acid, polymers having a molecular weight of 3000 or more such as methyl cellulose, ethyl cellulose and polyvinyl alcohol, clay minerals such as montmorillonite and laponite, gum arabic and vigum , Gums such as guar gum, and the like.

In the external preparation for skin of the present invention, the combined use of erythritol and the above-mentioned plant crude drug and the skin-covering component synergistically improves the rough skin improving effect as compared with the case where they are used alone. The external preparation for skin of the present invention refers to cosmetics, pharmaceuticals, quasi drugs, etc. applied to the outer skin, and its dosage form is an aqueous solution-based, solubilized-based, emulsion-based, powder-based, oil-based, gel-based system. , An ointment system, a water-oil two-layer system, a water-oil-powder three-layer system, and the like.

In addition to the above-mentioned essential components, the external preparation for skin of the present invention may contain other components which are usually used in external preparations for skin such as cosmetics and pharmaceuticals within a range that does not impair the effects of the present invention. For example, powder components such as titanium dioxide, mica, talc, para-aminobenzoic acid, homomenthyl-7N-acetylalanthranilate, butylmethoxybenzoylmethane, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate, amyl salicylate. UV absorbers such as octyl cinnamate and 2,4-dihydroxybenzophenone, moisturizers such as polyethylene glycol, glycerin, sorbitol, xylitol and maltitol, organic solvents such as ethanol and 1,3-butylene glycol, butylhydroxytoluene, Tocopherol,
Antioxidants such as phytic acid, benzoic acid, salicylic acid, sorbic acid, alkyl esters of paraoxybenzoic acid (ethyl paraben, butyl paraben, etc.), antibacterial preservatives such as hexachlorophene, glycine, alanine, valine, leucine, serine, threonine, Amino acids such as phenylalanine, tyrosine, aspartic acid, asparagine, glutamine, taurine, arginine and histidine, and their alkali metal salts and hydrochlorides, acylsarcosine acid (eg sodium lauroylmethylsarcosinate), glutathione, citric acid, malic acid, tartaric acid. , Organic acids such as lactic acid, vitamin A and its derivatives, vitamin B ₆ hydrochloride,
Vitamin B ₆ tripalmitate, Vitamin B ₆ dioctanoate, Vitamin B ₂ and its derivatives, Vitamin B ₁₂ ,
Vitamin B ₁₅ and its derivatives such as vitamin B, ascorbic acid, ascorbic acid sulfate (salt), ascorbic acid phosphate (salt), ascorbic acid dipalmitate and other vitamin Cs, α-tocopherol, β-
Vitamin Es such as tocopherol, γ-tocopherol, vitamin E acetate, vitamin E nicotinate, vitamins D, vitamin H, pantothenic acid, vitamins such as pantethine, nicotinamide, benzyl nicotinate, γ-oryzanol, allantoin, glycyrrhizin Acid (salt), glycyrrhetinic acid and its derivatives, hinokitiol, mucidin, bisabolol, eucalyptol,
Thymol, inositol, saponins (saikosaponin, carrot saponin, hemimasaponin, muclodisaponin, etc.), pantothenyl ether, ethinyl estradiol, cepharantin, placenta extract, etc. Mallow, senkyu, senburi, thyme, touki, spruce, birch, horsetail, loofah, horse chestnut, yukinoshita, arnica, lily, mugwort,
Natural extracts extracted with organic solvents of plants such as peony, aloe, gardenia, and mackerel, alcohol, polyhydric alcohol, water, aqueous alcohol, pigments, sorbitan monolaurate, sorbitan monopalmitate, sorbitan sesquioleate, trioleate Sorbitan, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyethylene glycol monooleate, polyoxyethylene alkyl ether, polyglycol diester, lauroyl diethanol amide, fatty acid isopropanol amide, maltitol hydroxy aliphatic ether, alkylation Nonionic surfactants such as polysaccharides, alkyl glucosides, sugar esters, stearyl trimethyl ammonium chloride, benzal chloride Chloride, cationic surfactants such as lauryl amine oxide, sodium palmitate,
Sodium laurate, sodium lauryl sulphate, potassium lauryl sulphate, alkylsulfuric acid triethanolamine ether, funnel oil, linear dodecyl benzene sulphate, polyoxyethylene hydrogenated castor oil maleic acid, anionic surfactants such as acylmethyltaurine, amphoteric surfactant Agent,
Fragrances, purified water and the like can be added.

[0014]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.
In addition, the compounding amount is expressed in% by weight unless otherwise specified. [Rough skin improvement test] The back skin of a healthy man was treated with a 3% sodium dodecyl sulfate aqueous solution to prepare rough skin. After 2 hours, 20 μl of each sample was applied in an open manner. This was repeated for 5 days, and on the 6th day, the state of rough skin was visually observed and scored according to the criteria in Table 1. The higher the score, the higher the effect of improving rough skin.

[0015]

[Table 1] ─────────────────────────────────── Scores Standards of scores ───── ────────────────────────────── 1 A wide range of horny layer dryness, swelling, and strong erythema are observed. 2 Dry, swelling and moderate erythema on the stratum corneum. 3 Dryness of the stratum corneum is observed, but no curling is observed. Weak erythema. 4 Dryness and turning of the stratum corneum are not observed, but some erythema is observed. 5 Dryness, swelling and erythema of the stratum corneum are not observed. ───────────────────────────────────

The male panel was made up of 10 persons in each group, and the rough skin improving effect of each sample was judged based on the average value of the scores of 10 persons. Judgment ◎: Average score is 4 or more ○: Average score is 3 or more and less than 4 Δ: Average score is 2 or more and less than 3 ×: Average score is less than 2

[0017]

[Table 2] ──────────────────────────────────── Sample 1 2 3 4 5 6 6 ─── ───────────────────────────────── Erythritol 10 8 6 4 2 0 Loquat leaf extract 0 2 4 6 8 10 Hydroxypropyl cellulose 0.5 0.5 0.5 0.5 0.5 0.5 Purified water Residue ──────────────────────────────────── Evaluation △ ○ ○ ○ ○ △ ─────────────────────────────────────

From Table 2, it can be seen that the combination of the skin-covering component (hydroxypropyl cellulose) and erythritol or the botanical herb medicine (loquat leaf extract) does not substantially improve the rough skin, but the combination of these three compounds is effective. It is understood that the rough skin improving effect is synergistically increased.

Next, a skin external preparation was prepared according to the formulation shown in Table 3 below, and the same rough skin improvement test as described above was conducted. At the same time, the usability was also investigated. The evaluation criteria for the feeling of use are as follows. ◎: No sticky feeling ○: Almost no sticky feeling △: Slightly sticky ×: Sticky

[0020]

[Table 3] ──────────────────────────────────── Sample 7 8 9 9 10 11 12 12 13 14 ─ ─────────────────────────────────── Glycerin 5 15 20 30 30 − − − − Erythritol − − − − 5 15 20 30 Loquat leaf extract 5 15 20 20 20 5 15 20 20 Bentonite 5 5 5 5 5 5 5 5 5 5 Lanolin alcohol 1 1 1 1 1 1 1 1 1 POE (50) hydrogenated castor oil 1 1 1 1 1 1 1 1 1 1 Purification Water residue ──────────────────────────────────── Rough skin prevention effect △ ○ ◎ ◎ ○ ◎ ◎ ◎ ◎ Usability ◎ ○ ○ × ◎ ◎ ◎ ○ ─────────────────────────────────────

As shown in Table 3, when the conventional moisturizer (glycerin) was used, it had an effect of improving rough skin, but it had a sticky feeling at high concentrations. On the other hand, the system in which erythritol or a botanical herb and a skin-covering ingredient were used in combination had no sticky feeling even at a high concentration, and was excellent in the effect of improving rough skin.

[0022]

[Table 4] ──────────────────────────────────── Sample 15 16 17 18 18 19 20 21 22 22 ─ ─────────────────────────────────── Erythritol − − − − 10 10 10 10 Peach leaf extract 10 − −−10 −−− Aloe extract −10 −−−− 10−− Korean ginseng extract −−− 10 −−− 10− Luffa extract −−− 10 −−−− 10 Bentonite 5 5 5 5 5 5 5 5 5 Lanolin alcohol 11 1 1 1 1 1 1 1 POE (50) hydrogenated castor oil 1 1 1 1 1 1 1 1 1 water residual balance ────────────────────────── ────────── Skin roughening prevention effect △ △ △ △ ◎ ◎ ◎ ◎ ◎ ─────────────────── ───────────────── from Table 4, in the skin covering component and the combination system of erythritol and various plant crude drugs, is understood to have a rough skin improving effect.

[Actual Use Test by Replica Method] The skin surface morphology of the face of a healthy female panelist is replicated using a silicone resin replica method, and a microscope (1
7 times). Rough skin was evaluated based on the criteria shown in Table 5 from the state of the skin pattern and the peeling state of the stratum corneum, and the panelists judged to have a score of 1 or 2 were set to 20 people per group, and Table 6 is shown on the right half of the face. Lotion of Formulation Example 1 or Formulation 2 of Comparative Example 1 was applied to the left half for 2 days each.
It was applied twice. Two weeks later, a replica was taken again and the skin condition was observed and evaluated in the same manner as above.

[0024]

[Table 5] ─────────────────────────────────── Scores Standards of scores ───── ────────────────────────────── 1 Skin clefts, disappearance of cuticles, and wide skin keratinization 2 skins Grooves and crusts are unclear, and horny layer is turned up. 3 Crusts and crusts are observed, but flat 4 Crusts, crusts are clear 5 Crusts, crusts are clear and regular ──── ───────────────────────────────

In each group, the rough skin improving effect was judged as follows. Judgment ○: The proportion of panelists who were evaluated as 4 or 5 is 75
% Or more △: The proportion of panelists evaluated as 4 or 5 is 25
% Or more and less than 75% x: The proportion of panelists evaluated as 4 or 5 is 25
The results of less than% are shown in Table 6.

[0026]

[Table 6] ─────────────────────────────────── Component Composition example 1 Composition example 2 Comparative example 1 ─ ────────────────────────────────── Erythritol 1.5 1.5 − Peach leaf extract 1.5 − − Loofah extract − 1.5 − Glycerin − − 3.0 Squalane 2.0 2.0 2.0 Propylene glycol 1.0 1.0 1.0 Citric acid 0.2 0.2 0.2 95% Ethanol 10.0 10.0 10.0 POE (20) Lauryl ether 0.5 0.5 0.5 Perfume proper amount proper amount Purified water Residual residue Residual residue ──────── ─────────────────────────── Evaluation ○ ○ △ ──────────────────── ──────────────── As can be seen from Table 6, the external preparation for skin according to the present invention is an external preparation for skin which is excellent in improving rough skin. .

When the external preparations for the skin of the following formulation examples 3 to 11 were prepared by a conventional method, they all had the effects of preventing and improving skin roughness, and had a good feeling in use, and also had papules, pimples, blister and erythema. It was a highly safe external preparation for the skin that did not cause the above.

Formulation 3 Pack Kaolin 70.8 wt% Talc 23.0 Propylene glycol 5.0 Calcium acetate 0.01 Urea 0.5 Erythritol 0.3 Loquat leaf extract 0.1 Perfume Suitable amount

Formulation Example 4 Nourishing Cream Stearic Acid 2.0 wt% Stearyl Alcohol 7.0 Reduced Lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 Maltitol Hydroxylauryl Ether 3.0 Glyceryl Monostearate 2.0 Preservative Agent Adequate amount Perfume Adequate amount Propylene glycol 5.0 Erythritol 8.0 Loquat leaf extract 0.2 Singhhong Ginseng extract 0.1 Purified water Residual

Blending Example 5 Lip Treatment Candelilla Wax 9.0 wt% Solid Paraffin 8.0 Beeswax 5.0 Carnauba Wax 5.0 Lanolin 11.0 Castor Oil Residual Erythritol 18.0 Peach Leaf Extract 10.0 Isopropyl myristate 10.0 Sucrose fatty acid ester 2.0 Fragrance Suitable amount Antioxidant Residual

Formulation 6 Emulsion stearic acid 2.0 wt% Cetanol 1.0 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 8.0 Squalane 2.0 2-Ethylhexyl paradimethylaminobenzoate 2.0 Erythritol 10.0 Aloe extract 0.5 Polyoxyethylene (10) monooleate 2.5 Triethanolamine 1.0 Propylene glycol 5.0 Preservative A suitable amount Perfume Suitable amount Purified water Residual

Formulation Example 7 Emulsion Stearic acid 2.0 wt% Cetanol 1.0 Vaseline 3.0 Lanolin alcohol 2.0 Liquid paraffin 8.0 Squalane 2.0 Octyl methoxycinnamate 2.0 Erythritol 5.0 Ginseng extract 2 0.0 Loquat leaf extract 3.0 Polyoxyethylene (10) monooleate 2.5 Triethanolamine 1.0 Propylene glycol 5.0 Preservatives proper amount Perfume proper amount Purified water Residue

Formulation Example 8 Nourishing Cream Stearic Acid 2.0 wt% Stearyl Alcohol 7.0 Reduced Lanolin 2.0 Squalane 5.0 Octyldodecanol 6.0 Maltitol Hydroxylauryl Ether 3.0 Glyceryl Monostearate 2.0 Preservative Agent Suitable amount Perfume Suitable amount Propylene glycol 5.0 Erythritol 1.0 Peach leaf extract 0.5 Loquat leaf extract 0.3 Purified water Residual

Formulation 9 Pack Kaolin 65.0 wt% Talc 19.0 Propylene glycol 5.0 Calcium acetate 0.01 Urea 0.5 Erythritol 0.2 Peach leaf extract 0.3 Aloe extract 0.3 Perfume Suitable amount

Formulation 10 Lip Treatment Candelilla Wax 9.0 wt% Solid Paraffin 8.0 Beeswax 5.0 Carnauba Wax 5.0 Lanolin 11.0 Castor Oil Residual Erythritol 20.0 Loofah Extract 15.0 Aloe Extract 10.0 Isopropyl myristate 10.0 POE (60) hydrogenated castor oil 2.0 Perfume proper amount antioxidant remaining

[0036]

The external preparation for skin of the present invention is an external preparation for skin which is excellent in improving and preventing skin roughness, does not cause papules, blisters, vesicles, erythema, etc. is there.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display location A61K 35/78 ADA W 8217-4C

Claims (3)

[Claims] 1. An external preparation for skin comprising erythritol, a herbal medicine and a skin-covering ingredient. 2. The external preparation for skin according to claim 1, wherein loquat (Eriobotrya japonica) and peach (Pru) are used as herbal medicines.
nus persica), aloe (Aloe arborescens), ginseng (Panax Ginseng), loofah (Luffa cylindril)
An external preparation for skin, comprising one or more natural extracts extracted from l). 3. The external skin preparation according to claim 1 or 2, wherein the skin-covering ingredient is oil, wax, hydrocarbon-based or silicone-based oil, fatty acid, higher alcohol, ester oil, gum, molecular weight of 3000 or more. An external preparation for skin, characterized in that any one kind or two or more kinds of the polymers or the clay minerals mentioned above is blended.