JPH06128137A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic excellent in skin aging-preventive effect such as chapped skin improving effect and skin elasticity recovering effect. CONSTITUTION:The objective cosmetic formulated with (A) 0.35-14wt.% of farnesol and/or a derivative therefrom, (B) 0.15-6wt.% of pantothenol and/or a derivative therefrom and, if needed, (C) 0.000005-3wt.% of cell activator such as phytosterol glycoside, sulfated alginic acid, ethynyl estradiol, allantoin, bovine blood-freed protein, L-ascorbylmagnesium phosphate, water-soluble placenta extract, or heparin-like substance.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics, and more particularly to cosmetics containing farnesol and its derivatives and pantothenol and its derivatives.

[0002]

2. Description of the Related Art It is well known that aged skin loses its flexibility and elasticity, increases wrinkles on the skin, and becomes dry and rough skin. It is said that such skin aging occurs as a result of a decrease in skin cell regeneration and a decrease in metabolic activity depending on age and environment.

Conventionally, in order to prevent and improve such skin aging, essential fatty acids such as linoleic acid (JP-A-62-3).
9511) or Vitamin E (JP-A-62-39).
No. 511) is being administered.

When essential fatty acids such as linoleic acid are deficient, skin desquamation and the like occur, and skin aging is significantly accelerated. In order to prevent this, essential fatty acids, or vegetable oils or the like containing them have been blended in cosmetics, but the effect of preventing skin aging is not sufficient, and rancidity and the like easily occur, There is a problem of lack of stability.

Even if vitamin E is used alone, almost no moisturizing action, antiaging effect, wrinkle-eliminating action, and beautiful skin-improving action for beautiful skin with fine texture are obtained. In addition, there is a problem that it is discolored by heating and light, and it emits an odor, resulting in poor stability.

[0006]

SUMMARY OF THE INVENTION The present invention has been made from the above point of view, and has an effect of preventing skin aging, such as an effect of improving rough skin, an effect of improving wrinkles, an effect of giving a good feeling to the skin and keeping it healthy. It is an object to provide excellent cosmetics.

[0007]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that when farnesol and its derivatives and pantothenol and its derivatives are used in combination, the effect of preventing skin aging is improved. They have found that they can be remarkably exhibited, and have completed the present invention.

That is, the present invention provides farnesol and / or
Alternatively, it is a cosmetic containing 0.35 to 14% by weight of its derivative and 0.15 to 6% by weight of pantothenol and / or its derivative.

The present invention will be described in detail below. <1> Components Used in the Present Invention (1) Farnesol and its Derivatives Farnesol is a natural product widely existing in the plant kingdom and is also contained in various essential oils. Farnesol is also known to become an element of sterol biosynthesis after percutaneous absorption. Examples of the farnesol derivative used in the present invention include farnesol acetate. These can be used alone or in any combination.

(2) Pantothenol and its Derivatives Pantothenol is said to be converted to the coenzyme pantothenic acid after percutaneous absorption to increase cell regeneration and increase skin water retention. Examples of the pantothenol derivative used in the present invention include panthenyl ethyl ether and triacetic acid pantothenol ester. These can be used alone or in any combination.

Induchem (Induchem)
(Germany) under the trade name Unitrienol T-27, Farnesol (30%), Farnesol acetate (40%), Pantothenol triacetate (30%)
Is commercially available and can be used as it is as a mixture of farnesol and pantothenol or their derivatives.

(3) Cell activating agent By using a cell activating agent together with the above farnesol and pantothenol or their derivatives, the effect of preventing skin aging can be further enhanced. Examples of such cell activating agents include phytosterol glycosides, sulfated alginic acid, ethinyl estradiol, allantoin, bovine blood deproteinization products, L-ascorbyl magnesium phosphate, water-soluble placenta extract, and heparin-like substances. They can be used as one kind or a mixture of two or more kinds.

Phytosterol glycosides are disclosed in JP-A-62-
72604 and JP-A-62-187404, bovine blood deproteinized protein is disclosed in JP-B-48-23908, and sulfated alginic acid is disclosed in JP-A-4-257509.
It is described in detail in the publication. Have been described.

Ethynyl estradiol and allantoin are widely used in cosmetics and are listed in the standard of cosmetic raw materials. L-ascorbyl magnesium phosphate and water-soluble placenta extract are widely used in cosmetics, and are listed in the cosmetic product type permission standards (supervised by the Ministry of Health and Welfare Pharmaceutical Affairs Bureau Examination 2nd Division) V and II, respectively. .

The heparin-like substance is mainly a polysulfate ester of mucopolysaccharide extracted from the lung containing bovine tracheal cartilage, and is listed in the Japanese Pharmacopoeia Standard for Pharmaceutical Ingredients 1983 (supervised by the Examination Division, Pharmaceutical Affairs Bureau, Ministry of Health and Welfare). There is.

<2> Cosmetic of the Present Invention The cosmetic of the present invention contains the above farnesol and / or its derivative and pantothenol and / or its derivative as essential components. Furthermore, you may use together said cell activator.

The blending amount of farnesol and / or its derivative is preferably 0.35 to 14% by weight with respect to the total amount of the cosmetic. If it is less than 0.35% by weight, a sufficient effect cannot be obtained. On the other hand, when it exceeds 14% by weight, safety problems occur and it becomes difficult to keep the cosmetic system stable.

The blending amount of pantothenol and / or its derivative is preferably 0.15 to 6% by weight based on the total amount of the cosmetic. If it is less than 0.15% by weight, a sufficient effect cannot be obtained. On the other hand, if it exceeds 6% by weight, safety problems occur and it becomes difficult to keep the cosmetic system stable.

When a cell activator is used in combination, the amount is preferably 0.000005 to 3% by weight based on the total amount of the cosmetic. 0.
If the amount is less than 000005% by weight, a sufficient effect cannot be obtained. If it exceeds 3% by weight, discoloration or odor will occur, which is not preferable in terms of stability and safety.

The cosmetic of the present invention may be added directly to a lotion, cream, emulsion, pack or the like, regardless of the dosage form.
Or solvents such as alcohols (eg ethanol)
It can be obtained by adding and blending what is dissolved in and performing treatments such as emulsification, mixing, decomposition and dissolution.

In the cosmetic of the present invention, in addition to the above components, various cosmetic bases and additives used in ordinary cosmetics, such as inorganic pigments, organic pigments, inorganic powders, organic powders, Bases and sugars such as hydrocarbons, silicones, esters, triglycerides, lanolins, waxes, waxes, animal and vegetable oils, surfactants, polyhydric alcohols, etc.,
Vitamin A, B vitamins, vitamins such as vitamin E, amino acids, glycyrrhizin and its derivatives, anti-inflammatory agents such as glycyrrhetinic acid and its derivatives, antioxidants, preservatives, perfumes, thickeners, astringents, ultraviolet rays Absorbent,
Additives such as a UV-reflecting agent, a whitening agent, and a rough skin improving agent can be added.

[0022]

EXAMPLES Examples of the present invention will be described below. In addition, the following compounding amounts are all parts by weight.

[0023]

Examples 1 to 8 Examples of creams as the cosmetics of the present invention will be described. (Manufacturing method) The components of Table 1A and B were heated to 75 ° C. to dissolve them, and then the component of B was added to the component of A to perform inversion emulsion. This was cooled to 30 ° C. to obtain oil-in-water creams of Examples 1-8 and Comparative Example 1.

[0024]

[Table 1] (Evaluation) Next, in order to examine the effect of each cream,
A use test, a rough skin improving effect test, a stratum corneum peeling state improving effect test, and a wrinkle improving effect test were performed.

<1> Use Test (Method) The creams of the above-mentioned Examples and Comparative Examples were applied to the face of 50 female panelists (35-49 years old) twice a day for 1 day.
After continuous application for a month, the panelist himself performed sensory evaluation on the skin condition before and after the test. The evaluation items are
Five items shown in Table 2 were used, and each item was evaluated in three stages. The results are shown in Table 2.

[0026]

[Table 2] From these results, the cream of Example is superior to the cream of Comparative Example in the effect of moisturizing the skin, eliminating the dryness of the skin, and further keeping the skin healthy and reducing fine lines. Recognize.

<2> Skin roughening improving effect test and stratum corneum peeling state improving effect test Targeting 50 middle-aged and elderly people with rough skin on the forearm, twice a day for one month, Examples 1, 2, 5 or Comparative Example 1 Was continuously applied, and a rough skin improving effect test and a stratum corneum peeling condition improving effect test were performed.

(1) Skin Roughness Improvement Effect Test (Experimental Method) The condition of the skin before and after the test is judged according to the following criteria, and the judgment results of the test site before and after the test and the control site are compared to dry skin When the degree was improved by two stages or more (for example, + → −, ++ → ±), it was defined as “valid”, when it was improved by 1 stage, it was defined as “slightly valid”, and when there was no change, it was defined as “invalid”. Incidentally, there was no case where the skin became dry during the test period.

-: Normal ±: Minor dryness, no desquamation +: Dry, mild desquamation ++: Dry, moderate desquamation +++: Dry, remarkable desquamation

(2) Test for improving effect of exfoliation of stratum corneum The stratum corneum was sampled using cellophane tape, soaked in alcohol for 10 minutes, and then applied to a dyeing solution (1% gentian violet: 0.5% brilliant green aqueous solution). About 10
After soaking for -15 minutes, it was soaked in running water until no dyeing solution came out, and dried with a dryer. Then, the stained corneal cells are sealed with balsam solution and observed under a microscope.
The evaluation was made in 3 stages.

The results of the above tests are shown in Table 3.

[0032]

[Table 3]

<3> Wrinkle Improvement Test Next, a wrinkle improvement test was conducted. (Method) The cream of Examples 1, 4, 5 or Comparative Example 1 was applied twice a day to the faces of 30 middle-aged (35-49 years old) female panelists, and one month later, before the start of the test. And, regarding the condition on the skin after the end, the three items shown in Table 4 were evaluated. The effect of improving wrinkles was evaluated as follows.

The silicon replica collected from the skin was fixed on a glass plate, and parallel rays were irradiated to the replica from an oblique direction (25 degrees). When it is photographed from directly above with a TV camera, the convex portions are bright and the concave portions are dark due to the shadows corresponding to the irregularities of the replica. This brightness was converted into a luminance value, and Ra (average roughness), waveform, and Sm value (distance between skin grooves) were obtained. In addition, the naked eye judgment of the replica photograph was performed at the same time to evaluate the wrinkle reducing effect. The above results are shown in Table 4.

[0035]

[Table 4] From this result, it is understood that the cream of the present invention is excellent in the wrinkle reducing effect.

[0036]

[Embodiment 9] Next, as a cosmetic of the present invention, an embodiment in a lotion will be described. (Manufacturing method) All the ingredients shown in Table 5 were homogeneously mixed and dissolved at room temperature to obtain a lotion.

[0037]

[Table 5]

[0038]

[Embodiment 10] As a cosmetic of the present invention, an embodiment in an emulsion will be described. (Manufacturing Method) Each of the components shown in Tables 6A and 6B was heated to 75 ° C. and dissolved. After this, B was added to A, and the emulsion was inverted.
It cooled to 0 degreeC and obtained the oil-in-water type emulsion.

[0039]

[Table 6]

[0040]

[Embodiment 11] Further, an embodiment of the pack charge will be described. (Manufacturing method) All the components shown in Table 7 were homogeneously mixed and dissolved at room temperature to obtain a pack.

[0041]

[Table 7]

[0042]

The cosmetics of the present invention are excellent in the effect of preventing skin aging, such as the effect of improving skin roughness, the effect of improving wrinkles, the effect of giving a good feel to the skin, and the effect of keeping them healthy.

Continuation of front page (51) Int.Cl. ⁵ Identification number Office reference number FI Technical display location A61K 7/00 K 7252-4C W 7252-4C H 7252-4C

Claims (3)

[Claims] 1. A cosmetic containing farnesol and / or a derivative thereof in an amount of 0.35 to 14% by weight and pantothenol and / or a derivative thereof in an amount of 0.15 to 6% by weight. 2. A cell activating agent is further added in an amount of 0.000005.
The cosmetic according to claim 1, wherein the cosmetic is contained in an amount of 3 wt%. 3. The cell activating agent is phytosterol glycoside, sulfated alginic acid, ethinyl estradiol,
The cosmetic according to claim 1 or 2, wherein the cosmetic is selected from the group consisting of allantoin, bovine blood deproteinate, magnesium L-ascorbyl phosphate, water-soluble placenta extract, and heparin-like substance.