JP2532495B2 - Skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a cosmetic composition which markedly improves the flexibility, elasticity and surface condition of the skin. More specifically, the present invention relates to a skin cosmetic that moisturizes the skin and improves the physiological function of the skin to remarkably improve the flexibility, elasticity and surface condition of the skin.

[Conventional technology]

As the skin ages, the water retention function of the skin deteriorates and the skin becomes dry and moist. It is said that the cause is that glycosaminoglycan in the skin decreases with age.

Until now, cosmetics have blended glycosaminoglycan, which is lacking in the skin, and have tried to moisturize and moisturize the skin with hyaluronic acid, which has a strong water retention property (JP-B-33-500). Issue, Shokoku Sho 55-160712
issue). However, since supplementation of the moisturizing component from the outside has a limited effect, a physiologically active substance involved in hyaluronic acid synthesis has been blended in order to act on the inside of the skin to enhance the function of the skin and enhance the moisturizing property. For example, cosmetics containing estrogen that enhances hyaluronic acid biosynthesis in the dermis,
Cosmetics that seek a synergistic effect by combining estrogen and glycosaminoglycan (Japanese Patent Laid-Open No. 59-25311), blend with vitamin A that enhances hyaluronic acid biosynthesis in the epidermis, or combine glycosaminoglycan Techniques such as cosmetics containing a combination of vitamin A (JP-A-60-252405) have been disclosed.

[Problems to be solved by the invention]

However, the glycosaminoglycan replenished from the outside is easily washed off by washing the face, sweating, etc., so that the cosmetic containing only glycosaminoglycan was insufficient in terms of long-term effect. Estrogen and Vitamin A work from the inside of the skin and can be expected to have a long-term effect, but estrogen has most of the effect on the dermis, and cosmetics containing estrogen and glycosaminoglycan are closely related to the condition of the epidermis. It can hardly be expected to have an effect on the smoothness and proper moisturization of the skin surface, while vitamin A has the most effect on the epidermis, and cosmetics containing vitamin A and glycosaminoglycan have elasticity on the skin. , It is considered that there is almost no effect on the dermis that influences the proper firmness of the skin. Therefore, the conventional techniques are insufficient in terms of enhancing the water retention of the entire skin tissue, and have not shown sufficient effects on the deterioration of skin flexibility, elasticity and water retention with age.

[Means for solving problems]

Therefore, as a result of diligent research, the present inventors have increased the biosynthesis ability of glycosaminoglycans in the epidermis, and have increased the biosynthesis ability of vitamin A and dermis glycosaminoglycans that provide smoothness and appropriate moisturization to the skin Cosmetics containing a certain amount of estrogen that gives elasticity and moderate elasticity to the skin can be formulated with vitamin A, estrogen or glycosaminoglycan alone, a combination of estrogen and glycosaminoglycan, and vitamin A and glycosaminoglycan. The inventors have found that the effect of improving the flexibility, elasticity and surface condition of the skin is greater than the combination of noglycans, and have completed the present invention.

That is, the present invention relates to a skin cosmetic characterized by containing 0.001 to 0.01% by weight of vitamin A and 0.001 to 0.01% by weight of estrogen.

 Hereinafter, the present invention will be described in detail.

The estrogen used in the present invention is also known as "estrogen", and includes, for example, ethinyl estradiol, 17β.
-Estradiol, estrone, estriol, diethylstilbestrol, hexestrol and the like, and one or more of these are arbitrarily selected and used. The blending amount is 0.001% by weight or more and 0.01% by weight or less (less than 0.001% does not exhibit the effect, and if it exceeds 0.01%, there is a risk of side effects).

Vitamin A used in the present invention is, for example, retinol, retinal, dehydroretinol, dehydroretinal and their esters or carotene, lycobin,
These are provitamins such as zeaxanthin, cryptoxanthin, and echinenone, and one or more of these are arbitrarily selected and used. The blending amount is 0.001% by weight or more and 0.01% by weight or less (less than 0.001% does not exhibit the effect, and if it exceeds 0.01%, there is a risk of side effects).

The ratio of estrogen to vitamin A is effective in the skin in the range of 1: 1/2 to 2, and it is preferable to use it in the range of this ratio.

The skin cosmetics of the present invention include, in addition to the above-mentioned essential components, various components generally used in cosmetics, pharmaceuticals, etc., if necessary, within a range that does not impair the effects of the present invention, that is, an aqueous component, a powder component, an oil component, and a surfactant Agents, moisturizers, thickeners, antioxidants, fragrances, coloring materials, ultraviolet absorbers, vitamins, drugs and the like can be added. Also, depending on the composition ratio of vitamin A and estrogen shown in the preceding paragraph, glycosaminoglycan is added to the cosmetic in an amount of 0.01% or more and 10% or less in order to complement the effects of vitamin A and estrogen depending on the situation. It can be blended in a range (less than 0.01 is not sufficient to supplement the effect, and if it exceeds 10%, it is not preferable in terms of cosmetic dosage form).

The glycosaminoglycan used here is, for example, hyaluronic acid, chondroitin sulfate A, chondroitin sulfate B, chondroitin sulfate C, heplan, and / or salts thereof. As the base forming the salt of glycosaminoglycan, lithium hydroxide, potassium hydroxide, inorganic salts such as sodium hydroxide, organic bases such as triethanolamine and lysine, arginine, basic amino acids such as β-alanine It can be illustrated.

The present invention and the effects of the present invention will be described below with reference to examples.

(Manufacturing method) Component A (oil phase part) and component B (water phase part) respectively
After heating to 70 ° C. to completely dissolve, the oil phase part was mixed with the water phase part to emulsify, and cooled to 30 ° C. in a heat exchanger to prepare.

(Use test) The action effect of the skin cosmetic of the present invention was tested by a use test. In the use test, 70 female panelists were divided into 7 groups of 10 persons in each group, and the cream of Example 1 was used in the first group.
The cream of Comparative Example 1 was used for the second group, and Comparative Example 2 was used for the third group.
The cream of Comparative Example 1 to the 4th group and the 5th
The cream of Comparative Example 4 was applied to the group, the cream of Comparative Example 5 was applied to the sixth group, and the cream of Comparative Example 6 was applied to the seventh group.
It was applied once a day for 20 days, and the effect after 20 days was evaluated for the two items of "skin elasticity and proper firmness" and "skin moist feeling". The results are as shown in Table 1.

(Manufacturing method) Component A (oil phase) is added to component B (water phase) kept at 70 ° C.
And homogenize with a homomixer and then cool.

(Usage test) 70 people with 70 self-reported panelists for skin symptoms,
The first group contains the lotion of Example 2, the second group contains the lotion of Comparative Example 7, the third group contains the lotion of Comparative Example 8, and the fourth group contains the lotion of Comparative Example 9. To the fifth group, the lotion of Comparative Example 10 was added,
The lotion of Comparative Example 11 was applied to the 6th group, and the lotion of Comparative Example 12 was applied to the 7th group for 1 month, and the effectiveness thereof was determined by whether or not skin roughness was improved. The results are shown in Table-2.

As is clear from these results, the skin cosmetics containing vitamin A and estrogen are vitamin A or estrogen alone, a combination of vitamin A and glycosaminoglycan, a combination of estrogen and glycosaminoglycan. It was confirmed that the "elasticity" and "moisturizing feeling" were remarkably enhanced on the skin rather than the time, and "the rough skin was improved".

 Further examples are described below.

Example 3 Foundation Hydrophobized Fine Particle Titanium Oxide 7.0 Isostearic Acid Triglyceride 2.0 2-Octyldodecyl Olate 8.0 Liquid Paraffin 3.0 Cetyl Alcohol 5.0 Candelilla Wax 2.0 POE (25) Monostearate 2.0 Sorbitan Monostearate 1.0 Yellow Iron Oxide 1.3 Valve Pattern 0.8 Polyethylene glycol 4.0 Methylparaben 0.2 Sodium hyaluronate 0.5 Fragrance 0.2 Diethylstilbestrol 0.002 Retinal 0.002 Purified water Residual Example 4 Packed polyvinyl alcohol 20.0 Ethanol 20.0 Hyaluronate 0.2 Glycerin 5.0 Fragrance 0.3 Ethinyl estradiol 0.004 Retinal 0.004 Purified water Residual example 5 Oil Squalane 47.0 Castor oil 47.0 Diethylstilbestrol 0.005 Retinal 0.005 Purified water Residual

Claims (1)

(57) [Claims] 1. A skin cosmetic composition comprising 0.001 to 0.01% by weight of vitamin A and 0.001 to 0.01% by weight of estrogen.