JPS5925311A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic giving moistness to the skin, improving the physiological functions of the skin, and ameliorating the emollience, springiness and surface state of the skin, by combining glycosaminoglycane with estrogen which is a feminine hormone. CONSTITUTION:The objective cosmetic contains (A) one or more glycosamino- glycane (exhibiting rapid activity when applied to the skin) selected from hyaluronic acid, chondroitin sulfate A, chondroitin sulfate B, chondroitin sulfate C, chitin, etc. or their salts and (B) estrogen (which increase the amount of hyaluronic acid). EFFECT:The activity of the component is not additive but synergistic.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention provides moisture to the skin by blending glycosaminoglycan and estrogen,
The present invention relates to cosmetics that significantly improve the flexibility, elasticity, and surface condition of the skin by improving the physiological functions of the skin.

Skin 1+If From a medical point of view, the phenomenon of skin aging is believed to be due to a decrease in glycosaminoglycans in the skin. As a result, the skin tissue loses its softness and elasticity, the wrinkles of the skin increase, and the skin 9 [visually deteriorates]. Glycosaminoglycans, especially one of them, hyaluronic acid, are extremely effective! : Therefore, it is an extremely important factor when considering the mechanism of skin moisturization. Fragrance Journal (FR)
AGRAN (I JOURN/lL) No. 14 No. 43
~54 pages 1975).

Glycosaminoglycans, such as chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronine sulfate, to prevent skin aging or to rejuvenate the skin.
or cosmetics containing its salts (Special Publication No. 33-500)
Or an emulsified composition (especially) that contains hyaluronic acid and its salts to form a protective film on the skin, make the skin smooth, and provide appropriate moisture and firmness to the skin. Considering that the ingredients on the skin are easily washed away by face washing and sweat, they do not necessarily have sufficient anti-aging effects. It is difficult to say that it will.

In view of this situation, the present inventors proposed that it would be possible to not only provide RLI externally with glycosaminoglycans that are lacking in the skin, but also to simultaneously add 11-bolone that acts on the inside of the skin. We thought that it would be more effective, and as a result of making various prototypes and testing, we found that a cosmetic that contains glyc'-1 saminoglycan and paternal hormone has a higher mlr-like effect than a cosmetic that contains each of them alone. They discovered that this method has an effect, and completed the present invention.

1! II. The present invention provides a cosmetic product characterized by a combination of glycosaminoglycan and estrogen, which is a female hormone. It acts on glycosaminoglycans that exhibit fast-acting effects and the dermal connective tissue in the skin tissue, and provides hyaluronic inoculation replenishment and hyaluronic acid replenishment from within the skin's LM, but its effectiveness has been tested. As a result, they discovered that Sakae has a synergistic rather than a mutualistic effect, leading to the present invention.

(Margin below) Hereinafter, the configuration of the present invention will be explained in detail.

Glycosaminoglycans used in the present invention include, for example, hyaluronic acid, chondroitin sulfate! l'A1 chondroitin sulfate B1 chondroitin sulfate C1 chitin, etc., or salts thereof, and one or more types are arbitrarily selected from these.

Examples include basic amino acids such as nin as a base for forming glycosaminoglycan salts. preferable.

Estrogens used in the present invention include, for example, ethinyl estradiol, 7β-estradiA-luestrone,
These include Nistral, diethylstilbestrol, hexestrol, etc., and one or more of them are arbitrarily selected and used.

Blend 11 [is preferably 0.0001% by weight or more.

Hereinafter, the present invention and the effects of the present invention will be explained with reference to Examples. Engineering and description. The present invention is not limited thereby.

(Left below) Example 14 Comparative example 1.2 Moisture cream (
Manufacturing method) The oil phase of A and the aqueous phase of B are heated to 70°C and completely dissolved, and then the oil phase is added to the aqueous phase in Example 1 of 1111. The moisture cream of Comparative Example 1.2 was used on a woman's pie, Le Haname.

01υI lit January 10, 1980 - 2, 1982
] 0 days 0 How to use: Apply Example 1 and Comparative Example 1 to 10 people (l group), and apply Example 1 and Comparative Example 2 to 10 people on both sides of the face.
(Group II, Comparative Example 1 and Comparative Example 2) 0 people each (Group ■) applied the solution 1h times a day.

0 Evaluation Items Skin suppleness and skin firmness after one month were evaluated by having the panel self-report in a sensory test. The results are shown in Table 2.

(The following is a margin) Table 2 (j@ Next, the skin improvement effects of Example 1 and Comparative Example 1 were evaluated by measuring skin conductance.

jj method: The water retention state of the skin was evaluated by measuring the conductance value using a high frequency impedance meter (manufactured by Ibinis Co., Ltd.). Example 1 and Comparative Example 1 were applied once every day for two weeks, and the determined conductance values (a (measured by 10 people and expressed as an average value) before and after application) are shown in Table 3. Numerical values The larger the value, the better the skin condition.

As shown in Table 3, in Example 1, the water retention state of the skin was significantly improved compared to before application, whereas in Comparative Example 1, no such effect was observed.

Table 3 (Skin conductance after application) -, - (Skin conductance before application) Next, the effect of improving the skin surface condition of Example 1 and Comparative Example 1 was observed.

Method: Replica method of skin surface morphology (Japanese Patent Application Laid-open No. 54-56
No. 280).

Example 1 and Comparative Example 1 were applied once every day for two weeks, and replicas of the skin before and after application were taken, micrographs were taken, and comparative observations were made.

The results are shown in Figure 1. A shows the skin surface condition of the left cheek of a woman before use, and B shows the skin surface condition of the same woman's right cheek.

C is the surface condition of the left cheek after using the cream of Example 1.D is the surface condition of the right cheek after using Comparative Example 1.As is clear from these, before use, both were Although the skin morphology was similar, when the condition was observed after 2 weeks, the condyles and grooves were clearly defined in Example 1, indicating that the product of the present invention had a remarkable improvement effect.

On the other hand, in Comparative Example 1, the skin ridges and skin grooves were not clearly defined and almost no improvement effect was observed.

Example 2 Nutritional emulsion (manufacturing method) After heating the oil phase to the nutritional emulsion (manufacturing method) and the aqueous phase of B to completely dissolve them, the oil phase was mixed into the aqueous phase and emulsified using an emulsifier. do. The emulsion is subjected to final crystallization m'C in a heat exchanger.
After cooling to a certain temperature, filling was performed.

The same effect as in Example 1 of the cream was obtained.

Example 3 Skin lotion (IIZ) (Manufacturing method) Parts A and B were stirred and completely dissolved at room temperature, and then part A was mixed with part B to solubilize it, and the mixture was filtered using a filter.

0 had the same effect as Example 1

[Brief explanation of the drawing]

Figure 1 (photo) shows the morphology (skin surface condition) of an organism (human). A: Left cheek area before application B; Right cheek area before application c: 'Left cheek area after using the moisture cream of JNMM Example 1 D = Right cheek area after using the moisture cream of Comparative Example 1 Patent applicant Co., Ltd. Shiseido 1

Claims (1)

[Claims] A cosmetic characterized by containing glycosaminoglycan and estrogen.