JPS62209009A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic containing mucopolysaccharide, vitamin E and inorganic salt as essential components, effective in preventing drying and roughening of skin, giving springiness and softness to the skin and having excellent moisture-retaining and protecting effect. CONSTITUTION:A cosmetic containing 0.001-3.0wt% mucopolysaccharide (e.g. hyaluronic acid, chondroitin-4-sulfuric acid, etc.), 0.001-2.0wt% vitamin E and 0.01-5.0wt% inorganic salt (e.g. NaCl, potassium dihydrogen phosphate, etc.). The activities of the components are synergetically exhibited in the cosmetic to achieve remarkable and unique moisture-retaining effect. Accordingly, the cosmetic has excellent skin-protecting effect and moisture-retaining property.

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to a novel cosmetic, and more particularly to a cosmetic that essentially contains mucopolysaccharides, vitamin E, and inorganic salts. . An object of the present invention is to provide a cosmetic that prevents skin dryness and roughness, imparts elasticity and flexibility to the skin, and has excellent moisturizing and skin protective effects. [Conventional technology] The mechanism of moisturization in the skin is still unclear due to the involvement of complex factors. Among these, the amount of water in the stratum corneum is a function of the structure and function of the stratum corneum. In the stratum corneum of healthy IfI skin, an appropriate amount of water is maintained by the balance between water supply from inside and outside the body and water evaporation from the skin. However, for people with dry skin that secretes little sebum, or when this balance is disrupted due to seasonal changes, the moisture content of the stratum corneum decreases, causing the skin to become dry and, in extreme cases, cracks and chapped skin. Sometimes. From this point of view, cosmetics containing humectants such as glycerin, sodium pyrrolidone carboxylate, and sodium lactate have generally been used to maintain the moisture content of the stratum corneum. In addition, attempts have been made to incorporate mucopolysaccharides, allantoin, collagen, and various plant extracts into cosmetics, as they are believed to have effects such as preventing rough skin and healing wounds (Japanese Patent Application Laid-open No. 57-183707 , H-1181319, etc.). On the other hand, vitamin E has long attracted attention for its antioxidant effect, and has been incorporated into cosmetics as an antioxidant. [Problems to be Solved by the Invention] However, although so-called humectants have the function of supplying moisture to the stratum corneum, they only have a temporary effect, and moreover, in a low-humidity environment, they conversely remove moisture from the stratum corneum. It has the disadvantage of depriving you of In addition, mucopolysaccharides, allantoin, collagen, plant extracts, etc. have excellent beauty effects as mentioned above, but nothing with satisfactory moisturizing effects has yet been obtained, and various studies have been conducted. The current situation is that [Means for Solving the Problems] In view of the above points, the present inventors conducted intensive research to obtain cosmetics with excellent moisturizing effects, and found that mucopolysaccharides, vitamin E, and inorganic salts By combining the essential ingredients,
It was discovered that an extremely significant moisturizing effect can be obtained, and the present invention was completed. That is, the present invention provides mucopolysaccharides, vitamin E,
The present invention provides a cosmetic that essentially contains inorganic salts, has an excellent moisturizing effect, and has a skin protective effect. The mucopolysaccharides used in the present invention include hyaluronic acid, hyaluronic acid-protein complex, chondroitin 4
ffi tuna, chondroitin 6 sulfate, chondroitin 4,
6-disulfate, dermatan sulfate, darmatan 4,6-disulfate,
Examples include keratan sulfate, heparan sulfate, chitin, and their salts and derivatives. Mucopolysaccharides are a type of skin component, and can be derived from animals, microorganisms, or synthetic products. That is, the origin, extraction method, and purification method are not particularly limited. If the amount of mucopolysaccharide in cosmetics is too small, it will not be effective, and it should be 0.0001 to 5. The range of Oi amount % is preferable from the viewpoint of usability and is sufficient for the purpose of the present invention, but it is more preferable that it is within the range of 0.001 to 3.02 [(amount %). Examples of the vitamin E used in cosmetics include vitamin E such as natural vitamin E, α-tocopherol, β-tocopherol, γ-tocopherol, and δ-tocopherol, and derivatives such as vinegar tocopherol and tocopherol nicotinate. The amount of vitamin E contained in is 0.0001
A range of ~5.0% by weight is effective for the present invention, but a range of o,oot ~2.0% by weight is more preferred. Furthermore, the inorganic salts that are essential in the present invention are sodium, potassium, and calcium. Physiologically acceptable salts of monovalent or divalent metals such as magnesium, sodium chloride. Potassium chloride, calcium chloride, magnesium chloride, magnesium sulfate, sodium hydrocarbon, disodium phosphorus dihydrogen, sodium phosphorus dihydrogen, potassium dihydrogen phosphate, and the like can be mentioned. The amount of inorganic salts in cosmetics is 0.01 to 5.0
It is effective to set the amount within the range of % by weight, and there is no adverse effect due to interaction with other ingredients in the cosmetic, so it is preferable.
In addition to the above-mentioned inorganic salts, other components such as glucose, which are usually used as components of physiological salt solutions, may also be blended. This does not impede the effects of the present invention. When blending the above-mentioned inorganic salts into cosmetics, one or more of the inorganic salts may be blended individually or dissolved in purified water beforehand and blended. , the blending method is not particularly limited, and the pH of the solution of the above inorganic salts is:
A range of 4.0 to 8.0 is appropriate since it does not irritate the skin. The cosmetics of the present invention are as described above. It is characterized by essentially containing J, vitamin E, and inorganic salts, but in addition, it also contains surfactants, oils, moisturizers, and ultraviolet absorbers that are commonly used in cosmetics. , alcohols, chelating agents, pHaJ adjusters, preservatives, thickeners, dyes, fragrances, etc. may be appropriately blended as necessary. The cosmetics referred to in the present invention are cosmetics intended for skin protection, and are particularly used as aqueous cosmetics such as skin lotions, calamine lotions, astringent lotions, hair lotions, and body lotions. [Example] Next, the present invention will be further explained by giving examples. These do not limit the present invention in any way. First, Table 1 shows the formulations of Example [11 and Comparative Example [1]
Eight types of samples (toners), Nos. 1 to 71, were prepared in a conventional manner, and their moisturizing effects were measured and subjected to a sensory test to compare their effects. In addition, the values in the table indicate weight %. (Margins below) Table 1 Table 1 (Continued) i) Measurement of moisturizing effect Twenty women aged 20 to 40 were used as test subjects. Four test sites each on the left and right forearm flexor sides were used. Each sample was applied to each test site. It was applied twice a day, in the morning and in the evening. The period of use was two weeks during the winter season. After the above application period is over, use the impedance meter (1,
The electrical conductivity of the test site was measured using a model 1.8°355 (manufactured by B, S, Co., Ltd.). The higher the conductivity value, the higher the amount of water in the stratum corneum. Judgment was made by assigning a score to each person as shown below, and the sum of the scores was determined as the evaluation score. Table 2 shows the number of people judged to be in each rank and the rating points. Table 2 Evaluation results if) Sensory evaluation 49 women with dry skin between the ages of 20 and 40 were used as subjects, 7 people in each group, a total of 7 groups, and one sample in each group was used for Example [1] and Comparative Example.

[We conducted a test using θ1. Evaluation,
The three items of ``effect of imparting elasticity to the skin'', ``effect of moisturizing'', and ``effect of preventing skin irritation'' were evaluated relative to the comparative example [71], and scores were given as below, and the total score was was calculated as an evaluation score. Table 3 shows the number of people who evaluated each rank and their evaluation scores. (Space below) Table 3 Evaluation Results As is clear from the above evaluation results, Example Nl-a)
It exhibits a remarkable moisturizing effect compared to the combination of vitamin E phase and inorganic salts alone or in combination, and has a rich moist feeling and is good for the skin. It also had an excellent skin protection effect of imparting elasticity and preventing rough skin. Example [2] Lotion (prescription) (weight%) (1)
Citric acid 0.1 (2
) Sodium citrate 0.2 (3) Sodium pyrrolidone carboxylate 0.5 (4) Glycerin 0.5 (5) Hamamelis extract 2.0 (8) Polyoxyethylene polyoxyb 0.50 Pyrencetyl ether (20
To, 0. . ap, o-) (7) Ethyl alcohol 15.0 (8
) Methyl halaoxybenzoate 0.05 (9) Flavor 0.1 (lO) Acetic acid d
1-α-tocopherol 0.05 (11) Hyaluronic acid 0.001 (12) Elastin 0.01 (13) Sodium chloride 0.65 (14) Potassium chloride 0.014 (15) Calcium chloride 0.012 (16) Sodium hydrogen carbonate 0.02 (17) Purified water Remaining amount (manufacturing method) A Dissolve (13) to (18) in (17). B (1) to (5), (11), (12) to A
Mix and dissolve. Mix and dissolve C(6) to (10) and mix with B. Example [3] Lotion (prescription) (wt%) (1)
Citric acid 0.1(2) Sodium resistant to citric acid 0.4(3) Sodium milk odium 0.8(4) Sodium pyrrolidonecarboxylate 0.8(5) 1.3-Butylene glycol 10.0(6) Polyacrylic Sodium acid (0.5% 0.8 aqueous solution) (7) Polyoxyethylene heptanooleate 0.2 Sorbitan (20E, O,) (8) Fragrance 0.01 (
8) Natural vitamin E O,1 (l
O) Sodium chondroitin sulfate 0.001 (
11) Collagen 0.01 (
12) Sodium chloride 0.9 (13
) Potassium chloride 0.02 (14)
Calcium chloride 0.02 (15)
Magnesium chloride 0.005 (1B
) Sodium hydrogen carbonate 0.1 (17)
Sodium dihydrogen phosphate 0.004 (18
) Glucose 0.1 (18)
Purified water Remaining amount (manufacturing method) A Dissolve (12) to (18) in (19). B Mix and dissolve (1) to (8), (10), and (11) in A. Mix and dissolve C(7) to (9), add to B, and mix and stir. Example [41 Calamine lotion (formulation) (wt%) (1)
Silicic anhydride 0.35 (2) Kaolin 0.2 (3) Zinc oxide 0.3 (4) Light calcium carbonate 0.9 (5) Red iron
0.002(8) 1',3-butylene glycol 3.0(7) Ethyl alcohol 12.0(8) Fragrance
0.15(9) Pyrrolidone carboxylic acid 0,1(]0) α-tocopherol
0.01(11) Hyaluronic acid-protein complex 0.01(12) Sodium chloride
O,5(13) Potassium chloride
0.042(14)11! Calcium chloride
0.024(15) Sodium bicarbonate 0.02(16) Glucose
0.1 (I7) Purified water
Remaining amount (manufacturing method) A Dissolve (12) to (16) in (17). B Mix (1) and (9) with A and stir. Add (10) and (11) to CB and further mix and stir. The cosmetics of Examples [21 to 4] obtained as described above were all excellent in moisturizing effect and felt good on use. [Effects of the Invention] As detailed above, the present invention provides a novel product that essentially contains mucopolysaccharides, vitamin E, and inorganic salts, thereby synergistically exhibiting the effects of these components. The aim is to provide cosmetics that are unique to the skin. That is, the present invention has made it possible to provide an extremely useful cosmetic that has an unprecedented moisturizing effect and is excellent in skin protection and moisture retention. that's all

Claims (1)

[Claims] (1) A cosmetic that essentially contains mucopolysaccharides, vitamin E, and inorganic salts.