JPS62209010A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic containing mucopolysaccharide, phospholipid and inorganic salt as essential components, effective in preventing drying and roughening of skin, giving springiness and softness to the skin and having excellent moisture-retaining and protecting effect. CONSTITUTION:The objective cosmetic contains (A) a mucopolysaccharide (e.g. hyaluronic acid, hyaluronic acid-protein complex, chondroitin-4- or -6-sulfuric acid, etc.), (B) a phospholipid (e.g. soybean lecithin, yolk lecithin, their additives, etc.) and (C) an inorganic salt (e.g. physiologically permissible salt of uni- or bivalent metal such as Ka, K, Ca, Mg, etc.) as essential components. Preferably, the amount of A and B is 0.0001-5.0wt% each and that of C is 0.01-5.0wt%. The activities of the components A-C are synergetically exhibited in the cosmetic to achieve remarkable moisture-retaining effect. Accordingly, a cosmetic (especially a water-based cosmetic) having excellent skin-protecting effect and moisture-retaining property can be produced.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a novel cosmetic, and more specifically, the present invention is characterized in that it essentially contains a mucopolysaccharide, a phospholipid, and an inorganic salt. It is related to cosmetics.

An object of the present invention is to provide a cosmetic that prevents skin dryness and roughness, imparts elasticity and flexibility to the skin, and has excellent moisturizing and skin protective effects.

[Conventional technology] The mechanism of moisturization in the skin is still unclear due to the involvement of complex factors. Among these, the amount of water in the stratum corneum is a function of the structure and function of the stratum corneum. In the stratum corneum of healthy skin, an appropriate amount of water is maintained through a balance between water supply from inside and outside the body and water evaporation from the skin.

However, for people with dry skin that secretes little sebum, or when this balance is disrupted due to seasonal changes, the moisture content of the stratum corneum decreases, causing the skin to become dry and, in extreme cases, to develop cracks and chapped skin. This may occur.

From this point of view, in order to maintain the moisture content of the stratum corneum, glycerin, sodium pyrrolidone carboxylate,
Cosmetics containing moisturizing agents such as sodium lactate have been used.

In addition, attempts have been made to incorporate mucopolysaccharides, allantoin, collagen, and various plant extracts into cosmetics as having effects such as preventing rough skin and healing wounds (Japanese Patent Laid-Open Publication No. 1983-1999-1). 183707, 80-1113819
other).

On the other hand, phospholipids have been known for a long time as constituents of biological membranes, but since they are amphiphilic substances, various applications have been investigated as emulsifiers in cosmetics.

[Problems to be Solved by the Invention] However, although so-called humectants have the function of supplying moisture to the stratum corneum, they only have a temporary effect, and moreover, in a low-humidity environment, they conversely remove moisture from the stratum corneum. It has the disadvantage of depriving you of

In addition, mucopolysaccharides, allantoin, collagen, plant extracts, etc. have excellent beauty effects as mentioned above, but nothing with satisfactory moisturizing effects has yet been obtained, and various studies have been conducted. The current situation is that

[Means for Solving the Problems] In view of the above points, the present inventors conducted intensive research to obtain cosmetics with excellent moisturizing effects, and as a result, they discovered that mucopolysaccharides, phospholipids, and inorganic salts It was discovered that an extremely significant moisturizing effect can be obtained by essential blending, and the present invention was completed.

That is, the present invention provides a cosmetic composition that essentially contains mucopolysaccharides, phospholipids, and inorganic salts, and has an excellent moisturizing effect and a skin protective effect.

The mucopolysaccharides used in the present invention include hyaluronic acid, hyaluronic acid-protein complex, chondroitin 4
Examples include sulfuric acid, chondroitin hexasulfate, chondroitin 4,6 disulfate, dermatan sulfate, darmatan 4.8 disulfate, keratan sulfate, heparan sulfate, chitin, and their salts and derivatives. Mucopolysaccharides are a type of skin component and are derived from animals and all living organisms.

Any synthetic product can be used. That is, the origin, extraction method, and purification method are not particularly limited.

If the amount of mucopolysaccharide in the cosmetic is too small, it will not be effective, and a range of 0.0001 to 5.0% by weight is preferable from the viewpoint of feeling of use, and is sufficient for the purpose of the present invention. , more preferably in the range of 0.001 to 3.0% by weight.

In addition, the phospholipids used in the present invention include natural phospholipids (lecithin) extracted from soybeans, egg yolks, etc.
Examples include phosphatidylcholine, phosphatidylethanolamine, sphingomyelin, etc., and derivatives thereof.

The amount of phospholipid in cosmetics is o, ooot ~
Although a range of 5.0% by weight is effective for the present invention,
More preferably, the content is in the range of 0.001 to 2.0% by weight.

Furthermore, the inorganic salts that are essential in the present invention are physiologically acceptable salts of monovalent or divalent metals such as sodium, potassium, calcium, and magnesium.
Sodium chloride, potassium chloride, calcium chloride, magnesium chloride, t! Examples include magnesium acid, sodium hydrogen carbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, and the like.

The amount of inorganic 1M in cosmetics is 0.01 to 5.
．． A range of 0% by weight is effective.

Moreover, there is no adverse effect due to interaction with other ingredients in cosmetics, which is preferable. In addition to the above-mentioned inorganic salts, it is also possible to incorporate other ingredients such as glucose, which is usually used as a component of physiological saline solutions. This does not impede the effects of the present invention.

When blending the above-mentioned inorganic salts into cosmetics, one or more of the inorganic salts may be blended individually, or they may be dissolved in purified water in advance and blended. , the blending method is not particularly limited, and the pH of the solution of the above inorganic salts is:
A range of 4.0 to 8.0 will not irritate the skin.

Appropriate.

The cosmetics of the present invention are characterized by essentially containing mucopolysaccharides, phospholipids, and inorganic IpAs as described above, but in addition, they also contain an interface commonly used in cosmetics. Active agents, oils, humectants, ultraviolet absorbers, alcohols, chelating agents, pH7A adjusters, preservatives, thickeners, pigments, fragrances, and the like may be blended as appropriate.

The cosmetics referred to in the present invention are cosmetics intended for skin protection, and are particularly used as aqueous cosmetics such as skin lotions, calamine lotions, astringent lotions, hair lotions, and body lotions.

[Example] Next, the present invention will be further explained by giving examples. These do not limit the present invention in any way.

First, Example [1] and Comparative Example [1] whose prescriptions are shown in Table 1.
Eight types of samples (toners), Nos. 1 to 71, were prepared in a conventional manner, and their moisturizing effects were measured and subjected to a sensory test to compare their effects.

In addition, the values in the table indicate weight %.

(Margins below) Table 1 Table 1 (Continued) i) Measurement of moisturizing effect 20 women aged 20 to 40 were used as test subjects. Four test sites each were placed on the flexor sides of the left and right forearms. Each sample was applied to each test site. It was applied twice a day, in the morning and in the evening. The period of use was two weeks during the winter season.

After the above application period is over, use the impedance meter (1,
The electrical conductivity of the test site was measured using a model 1.8°355 (manufactured by B, S, Co., Ltd.). The higher the conductivity value, the higher the amount of water in the stratum corneum.

Judgment was made by assigning a score to each person as shown below, and the total score was calculated as an evaluation score of -9.

Table 2 shows the number of people judged to be in each rank and the rating points.

Table 2 Evaluation results ii) Sensory evaluation 48 women with dry skin between the ages of 20 and 40 were used as subjects, 78 in each group, 7 groups in total. We conducted a usage test. The evaluations were "elasticity imparting effect on the skin", "moisturizing effect", and "
Relative evaluation was carried out using Comparative Example [7] as a control for the three items of ``effect on preventing rough skin'', and the scores were calculated as shown below, and the sum of the scores was determined as the evaluation score.

Table 3 shows the number of people who evaluated each rank and their evaluation scores.

(The following is a blank space) Table 3 Evaluation Results As is clear from the above evaluation results, the lotion of Example [1] contains mucopolysaccharides, phospholipids, and inorganic salts, either alone or in combination. In comparison, it exhibited a remarkable moisturizing effect, and also had an excellent skin protection effect, giving a rich moist feeling, giving elasticity to the skin, and preventing rough skin.

Example [2] Lotion (prescription) (wt%) 1)
Citric acid 0.1″, 2) Sodium citrate 0.4:3) Sodium lactate 0.8:4) Sodium pyrrolidonecarboxylate 0.8:5) 1.3-Butylene glycol 10.0 [B) Methyl cellulose ( 0.5% aqueous solution) 0.8-7) Polyoxyethylene polyoxybu 0.20 pyrene cetyl ether (20
E, 0. .

8P, O,) 8) Fragrance 0.019)
Egg yolk hydrogenated lecithin 0.1 (10) Sodium chondroitin sulfate 0.001 (11) Collagen 0.01 (12) Sodium chloride 0.04 (13) Potassium chloride 0.001 (14) Magnesium chloride 0.001 (15) Sodium hydrogen carbonate 0.005 (16) Sodium dihydrogen phosphate 0.001 (17)
Glucose 0.1 (18) Purified water Remaining amount (manufacturing method) A Dissolve (12) to (17) in (18).

Dissolve B (8) in (5).

C(1) to (4), (8), (10), (11
) are mixed and dissolved in A.

Mix and dissolve D (7) and (8) and mix with B and C.

Example [3] Astrinsend Lotion (Prescription)
(Weight%) (1) Citric acid
0.1(2) Sodium citrate 0.2(3) Sodium pyrrolidonecarboxylate 0.5(4) Glycerin
0.5 (5) Hamamelis extract
2.0(6) Ethyl alcohol
15.0(7) Methyl roseoxybenzoate 0
．． 05(8) Fragrance 0.
01(9) Soybean hydrogenated lecithin 0.0
5(lO) Hyaluronic acid 0.0
01 (11) Elastin 0.
01(12) Sodium chloride 0.
9(13) Potassium chloride 0.04
2(14) Calcium chloride 0.0
24(15) Sodium hydrogen carbonate 0.
02 (1G) Glucose 0.
1 (17) Purified water remaining amount (manufacturing method) A Dissolve (12) to (16) in (17).

Dissolve B (9) in (4).

C(1) to (3) and (5) are mixed and stirred into A, and then mixed with B.

Dissolve D(6) to (8) and add to C.

Add (10) and (11) to ED and mix.

Example [4] Calamine lotion (prescription) (wt%) (1)
Silicic anhydride 0.35 (2) Kaolin 0.2 (3) Zinc oxide 0.3 (4) Light calcium carbonate 0.9 (5) Red iron
0.002(8) 1.3-butylene glycol 3.0(7) Ethyl alcohol 12.0(8) Fragrance
0.15 (9) Pyrrolidone carboxylic acid 0.1 (10) Soybean lecithin
0.01(11) Hyanoυuronic acid-protein complex 0.01(12) Sodium chloride
0.8(13) Potassium chloride
0.02(14) Calcium chloride
0.02(15) Magnesium chloride
0.005/TON lj-base ↓
Rin m L II ^ r
I'1
l(17) Sodium dihydrogen phosphate 0.0
04 (1st day) Purified water remaining amount (
Manufacturing method) A Dissolve (12) to (17) in (18).

B Dissolve (10) in (8).

C(1) to (5) and (7) to (9) are mixed and stirred into A, and then mixed with B.

Add (11) to DC and mix.

Examples obtained as described above [Cosmetics Nos. 21 to 41 were all excellent in moisturizing effect and felt good when used. [Effects of the Invention] As detailed above, the present invention By essentially containing mucopolysaccharides, phospholipids, and inorganic salts, the present invention provides a novel cosmetic in which the effects of these components are synergistically exhibited.

That is, the present invention has made it possible to provide an extremely useful cosmetic that has an unprecedented moisturizing effect and is excellent in skin protection and moisture retention.

that's all Applicant: Kobayashi Kose Co., Ltd.

Claims (1)

[Claims] (1) A cosmetic that essentially contains mucopolysaccharides, phospholipids, and inorganic salts.