JPH04235111A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having excellent action for ameliorating chapped skin. CONSTITUTION:The objective cosmetic contains at least one kind of mucopolysaccharide selected from L-carnosine and its derivative, homocarnosine and its derivative and their salts and at least one kind of compound selected from soluble peptide and lecithin.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics having an excellent effect on improving rough skin.

0002

[Prior Art] Skin cosmetics containing L-carnosine or its salts are known (Japanese Unexamined Patent Application Publication No. 2-221213), and mucopolysaccharide (Japanese Patent Publication No. 2-7
No. 287), soluble peptide (Japanese Unexamined Patent Publication No. 116/1986)
No. 617), lecithin (Japanese Unexamined Patent Publication No. 62-298509)
It is known to use the following. It is also known that homocarnosine is an active ingredient of antitumor agents (
(Japanese Unexamined Patent Publication No. 16926/1983).

0003

SUMMARY OF THE INVENTION An object of the present invention is to provide a cosmetic having an excellent effect on improving rough skin.

0004

[Means for Solving the Problems] The present invention provides at least one member selected from the group consisting of L-carnosine or its derivatives, homocarnosine or its derivatives, and salts thereof.
The present invention relates to a cosmetic containing seeds and at least one selected from the group consisting of mucopolysaccharides, soluble peptides, and lecithin.

Examples of derivatives of L-carnosine or homocarnosine include alkanoyl having 1 to 5 carbon atoms and alkyl ester having 1 to 5 carbon atoms of L-carnosine or homocarnosine. Alkanoyl having 1 to 5 carbon atoms includes formyl, acetyl, propionyl, butyryl,
Examples of the alkyl group having 1 to 5 carbon atoms include valeryl, methyl, ethyl, propyl, isopropyl, butyl, and pentyl.

Alkanoyl-L-carnosine having 1 to 5 carbon atoms is a known compound (Japanese Unexamined Patent Publication No. 124750/1983). Alkanoyl homocarnosine having 1 to 5 carbon atoms can be obtained in the same manner as the method described in JP-A-58-124750, using homocarnosine instead of L-carnosine. Alkyl esters of L-carnosine and homocarnosine can be obtained in the same manner as the method for obtaining alkyl esters of peptides using L-carnosine and homocarnosine as raw materials (WO 88/00182).

Salts of L-carnosine, homocarnosine and their derivatives include their metal salts (sodium salts, potassium salts, calcium salts, magnesium salts, zinc salts, aluminum salts, etc.), ammonium salts, hydroxide metal salts ( Zinc hydroxide salts, etc.), inorganic acid salts (hydrochlorides, sulfates, nitrates, phosphates, etc.), and organic acid salts (acetates, lactates, tartrates, citrates, etc.). A method for obtaining L-carnosine salt and homocarnosine salt is disclosed in JP-A-2-221.
The salts of derivatives of L-carnosine and homocarnosine can be obtained in the same manner as described in the above-mentioned publications.

[0008] As mucopolysaccharides, hyaluronic acid or its salts (sodium salt, potassium salt, amino acid salt, etc.)
, hyaluronic acid protein complex, chondroitin 4-sulfate, chondroitin 6-sulfate, chondroitin 4,6-disulfate,
Examples include dermatan sulfate, dermatan 4,6 disulfate, keratan sulfate, heparan sulfate, and the like. Examples of soluble peptides include soluble collagen, soluble elastin, mucin, keratin, casein hydrolyzate, silk hydrolyzate, and the like.

Examples of lecithin include soybean lecithin, egg yolk lecithin, hydrogenated lecithin, and lysolecithin. The amount of L-carnosine or its derivatives, homocarnosine or its derivatives, and their salts in cosmetics is usually 0.01 to 10% by weight, and the amount of mucopolysaccharides, soluble peptides, and lecithin is usually 0.01 to 10% by weight. 005 ~5
Weight%.

Other ingredients of the cosmetic of the present invention include oils (waxes such as beeswax, candelilla wax, and carnauba wax, paraffin, lanolin, cetanol, squalene,
wheat germ oil, stearic acid, stearyl alcohol, ceresin, wax, etc.), surfactants (glyceryl monostearate, sorbitan monostearate, polyoxyethylene stearyl ether, sorbitan monostearate, polyoxyethylene sorbitan monostearate, (oxyethylene sorbitan triolate, sodium polyoxyethylene lauryl ether sulfate, coconut oil fatty acid amidopropyl betaine, sodium dehydroacetate, coconut oil fatty diethanolamide, polyoxyethylene hydrogenated castor oil, glycerin tri-2-ethylhexanoate, etc.), preservatives agents (methylparaben, ethylparaben, propylparaben, etc.), nutritional agents (capsicum tincture, allantoin, etc.), humectants (glycerin, propylene glycol, polypropylene glycol, pyrrolidone carboxylic acid, 1,3-butylene glycol, etc.), thickeners ( carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol, etc.), alcohol (ethyl alcohol, etc.), alkali (potassium hydroxide, sodium hydroxide, etc.), organic acid (citric acid, etc.), antioxidant (butyl hydroxyanisole, etc.), fragrance , purified water, etc. are used.

The cosmetics of the present invention can be used in various forms such as ointments, solutions, and solid forms such as various creams (cold creams, skin creams, lip balms, etc.), lotions, lotions, etc.
Manufactured as emulsion, jelly, pack, etc. Test examples showing the effects of the cosmetics of the present invention are shown below.

Test Example 1 Cold Cream Comparison Test Thirty-two women suffering from rough skin and wrinkles were divided into four groups of eight people each, and the cold cream of Example 1 was applied to the left half of the face, and the cold creams of Comparative Examples 1 to 4 were applied to the left half of the face. Each was applied to the right half of the face once or twice a day. Table 1 shows the results after one month.

Test Example 2 Comparative test of emulsions The same procedure as in Test Example 1 was carried out except that the emulsions of Example 2 and Comparative Examples 5 to 8 were used instead of the cold creams of Example 1 and Comparative Examples 1 to 4. went. The result is the first
Shown in the table.

Test Example 3 Comparative test of skin cream Test Example 1 was performed except that the skin creams of Example 3 and Comparative Examples 9 to 12 were used instead of the cold creams of Example 1 and Comparative Examples 1 to 4. I did the same. The results are shown in Table 1.

[0015]

[Table 1]

As is clear from the table, the majority of people found the cosmetics of Examples to be better.

[0017]

[Example] Examples and comparative examples are shown below. Note that % shown in Examples and Comparative Examples means % by weight.

Example 1

(%) (A) Liquid paraffin
30.0
beeswax
5
．． 0 lanolin

5.0 Setanol

2.0 Self-emulsifying glyceryl monostearate 3.5
Sorbitan monostearate
1.5 (B) Soluble collagen

1.0 L-carnosine

0.2 Methylparaben

0.2 concentrated glycerin

3.0 Carboxyvinyl polymer
0.5
potassium hydroxide
0.2
purified water
47.7
(C) Fragrance
0.
Component (B) heated and dissolved at 80° C. was added to component (A) heated and melted at 280° C., and emulsified with a homomixer. Then, after cooling to 50°C, component (C) was added, and the mixture was cooled to room temperature to obtain cold cream.

Comparative Examples 1 to 4 In Example 1, L-carnosine or soluble collagen shown in Table 2 and purified water were used instead of 0.2% L-carnosine, 1.0% soluble collagen, and 47.7% purified water. Cold cream was obtained in the same manner as in Example 1 except that water was used.

[0020]

[Table 2]

Example 2

(%) (A) Squalene

4.0 Wheat germ oil

2.0 Beeswax

2.5 Glyceryl monostearate 1.0
Polyoxyethylene (20 moles)

stearyl ether
4.0 Propylparaben
0.1 (B) Methylparaben

0.1 Propylene glycol
6.0 Polyethylene glycol 600
0 0.2
Sodium hyaluronate
0.1 L-carnosine
0.5 Purified water

79.3 (C) Fragrance

Component (B) heated and dissolved at 80° C. was added to component (A) heated and melted at 0.280° C., and emulsified with a homomixer. After cooling to 50° C., component (C) was added, and the mixture was cooled to room temperature to obtain a milky lotion.

Comparative Examples 5 to 8 In Example 2, L-carnosine or sodium hyaluronate shown in Table 2 was used instead of 0.5% L-carnosine, 0.1% sodium hyaluronate, and 79.3% purified water. A milky lotion was obtained in the same manner as in Example 2 except that purified water was used.

Example 3

(%) (A) Beeswax

2.0 Stearic acid

5.0 Stearyl alcohol
5.
0 reduced lanolin
2.
0 squalane
20
．． 0 Sorbitan monostearate
8.0
Polyoxyethylene (20 moles)
sorbitan monostearate
5.0 Polyoxyethylene (20 mol)
sorbitan triolate
3.0 Lysolecithin
0.4 (B) L-carnosine
0.2 Glycerin

6.1 Methylparaben
0.2 Purified water

42.9 (C) Fragrance

Component (B) heated and dissolved at 80° C. was added to component (A) heated and melted at 0.280° C., and emulsified with a homomixer. Then, after cooling to 50°C, component (C) was added, and the mixture was cooled to room temperature to obtain a skin cream.

Comparative Examples 9 to 12 In Example 3, L-carnosine 0.2%, lysolecithin 0.4% and purified water 42.9% were replaced with
A skin cream was obtained in the same manner as in Example 3, except that L-carnosine or lysolecithin and purified water shown in the table were used.

Example 4 The procedure of Example 1 was repeated except that 0.9 (%) of soluble collagen and 0.1 (%) of soluble elastin were used instead of 1% (w/w) of soluble collagen. I got cold cream.

Example 5 A cold cream was obtained in the same manner as in Example 1 except that 0.9% soluble collagen and 0.1% mucin were used instead of 1% soluble collagen.

Example 6

(%) (A) Polyoxyethylene lauryl
Ether sodium sulfate 30% solution
35.0 Coconut oil fatty acid amide propyl betaine 30% solution 9.0
Methylparaben
0.2
Sodium dehydroacetate
0.1 Coconut oil fatty acid diethanolamide
1.0 Polypropylene glycol
1.0
keratin
0.1
L-carnosine
0.2
citric acid
0.3
purified water
5
2.9 (B) Fragrance

0.2 Component (A) was dissolved at 70°C, cooled to 50°C, and component (B) was added thereto to obtain a hair dye.

Example 7

(%) (A) D-pantothenyl alcohol
0.2
Sodium hyaluronate
0.01 L-
carnosine
0.2 Capsicum tincture
0.5 Purified water

51.99 (B) Acetic acid d
l-α-tocopherol
0.2 l-menthol

0.2 Polyoxyethylene (
60 moles) hydrogenated castor oil

1.5 Ethyl alcohol
4
5.0 Fragrance

After adding the dissolved component (B) to the dissolved component (A), the mixture was filtered to obtain a hair tonic.

Example 8

(%) (A) Citric acid
0
．． 02 Sodium citrate
0.
2 dl-pyrrolidonecarboxylic acid
0.2
1,3-butylene glycol
4.0 Methylparaben
0.1 L-carnosine
0.1 Purified water

84.28 (B) Lysolecithin
0.125 Glycerin
0.375
Polyoxyethylene (60 mol)
hydrogenated castor oil
0.5
fragrance
0.1
Ethyl alcohol
Component (B) dissolved at 65° C. was added to component (A) dissolved at 10.065° C., and then cooled to room temperature to obtain a lotion.

Example 9

(%) (A) Candelilla wax
10.0
carnauba wax
4.0
Ceresin
3.0
microcrystalline wax
3.0
lanolin
10.0
liquid paraffin
10.0
Glycerin tri-2-ethylhexanoate
38.5 Butyl hydroxyanisole 0.1
(B) Castor oil
20.0
titanium oxide
1.0
soluble collagen
0.1
L-carnosine
0.1
fragrance
0.27
Component (B) heated and dissolved at 70° C. was added to component (A) heated and dissolved at 0° C., mixed, and then dispersed with a roller mill. After pouring this into a mold, it was rapidly cooled to obtain a lip balm.

Example 10

(%) (A) Polyvinyl alcohol
12.0
Methylparaben
0.1
Ethyl alcohol
8.0
fragrance
0.2 (
B) Sodium hyaluronate
0.2 L-carnosine
0.2 concentrated glycerin
4.0 dl-pyrrolidonecarboxylic acid
0.2 Allantoin

0.1 Purified water

Component (A) heated and dissolved at 70° C. was added to component (B) heated and dissolved at 75.070° C., mixed, and then cooled to room temperature to obtain a pack.

Example 11

(%) Soluble collagen
2.
0 L-carnosine
0.2
1,3-butylene glycol
1.0 Methylparaben
0.1 Purified water

After uniformly dissolving the entire 96.7, it was poured into a mold and freeze-dried to obtain a film pack.

Example 12 In Example 3, 0.2% lecithin, 5.0% propylene glycol, and 44.2% purified water were used instead of 0.4% lysolecithin, 6.1% glycerin, and 42.9% purified water. A skin cream was obtained in the same manner as in Example 3 except that % was used.

Example 13 A cold cream was obtained in the same manner as in Example 1 except that N-acetyl-L-carnosine was used instead of L-carnosine.

Example 14 A lotion was obtained in the same manner as in Example 8 except that N-acetyl-L-carnosine was used instead of L-carnosine.

Example 15 Same as Example 2 except that 0.1% of homocarnosine and 79.7% of purified water were used instead of 0.5% of L-carnosine and 79.3% of purified water. A milky lotion was obtained.

Example 16 Same as Example 1 except that 0.05% of homocarnosine and 47.85% of purified water were used instead of 0.2% of L-carnosine and 47.7% of purified water. Then you got cold cream.

Example 17 In Example 7, 0.1% homocarnosine was used instead of 0.2% L-carnosine and 51.99% purified water.
A hair tonic was obtained in the same manner as in Example 7 except that 52.09% of purified water was used.

[0039]

Effects of the Invention The cosmetic composition of the present invention has an excellent effect on improving rough skin.

Claims (1)

[Claims] [Claim 1] L-carnosine or a derivative thereof,
A cosmetic containing at least one member selected from the group consisting of homocarnosine, derivatives thereof, and salts thereof, and at least one member selected from the group consisting of mucopolysaccharides, soluble peptides, and lecithin.