JPH0665039A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having inhibitory action on collagen crosslinking and skin dressing action. CONSTITUTION:A cosmetic contains an extract of white lotus. The extract of white lotus is an extract of Ampelopsis japonica Makino of the family Vitaceae, for example, is obtained by extracting a dried product of hypertrophic root sold on the market with purified water, ethanol, 1,3-butylene glycol, propylene glycol, etc., alone or a mixed solvent. A foundation cosmetic, make-up cosmetic, bathing agent, etc., may be cited as the cosmetic.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics containing an extract of sandalwood.

[0002]

2. Description of the Related Art Wrinkles on the skin are a big problem for women.
Although many cosmetics for preventing wrinkles have been issued, the fact is that the moisturizing properties of hyaluronic acid, collagen, etc. substantially extend wrinkles, and there are few cosmetics that essentially prevent wrinkles.

[0003]

With the aging of the skin, the skin loses flexibility and elasticity, and wrinkles are formed. One of the causes of this wrinkle is cross-linking between collagen molecules formed as a result of collagen in the dermis being non-enzymatically modified by reacting with sugar and the like. Therefore, the application of the extract of sandalwood to cosmetics was examined. As a result, it showed excellent collagen cross-linking inhibitory action and skin-smoothing action, and it was possible to formulate the present invention, thus completing the present invention.

[0004]

DISCLOSURE OF THE INVENTION The present invention is a cosmetic containing an extract of sandalwood. In the present invention, the term juniper is used to describe the vine family Kagamigusa (scientific name:
Ampelopsis japonica Makino), and dried products of the daikon radish that are commercially available can be used.

The extract of sandalwood may be obtained, for example, by adding a single or mixed solvent of water, ethanol, 1,3-butylene glycol, propylene glycol or the like to a dried product of sandalwood, and extracting it by a conventional method at room temperature or by heating. You can The sandalwood extract can be concentrated or concentrated to dryness, if necessary, in order to facilitate subsequent operations. If necessary, the polysaccharide contained in the extract can be removed by precipitation by refrigeration or the like.

The extract of sandalwood is 0.0001 to 10% by weight, preferably 0.1% by weight of the total amount of the cosmetic of the present invention as a dry solid.
It is possible to add 01 to 5.0% by weight. When the concentration is 0.0001% or less, no sufficient effect is obtained, and when the concentration is 10% by weight or more, the effect is not enhanced and it is uneconomical. In the cosmetics of the present invention, oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, surfactants and the like used in cosmetics, etc., within a range that does not impair the effects of sandalwood extract. The raw materials can be mixed. As the cosmetic of the present invention, basic cosmetics such as creams, lotions, emulsions and packs, makeup cosmetics such as foundations and lipsticks, bath agents, and soaps can be used.

[0007]

EXAMPLES Next, examples will be given to explain the present invention in detail, but the present invention is not limited thereto. still,
The parts of the compounding amounts shown in the examples are parts by weight. Example-1 Extract of sandalgrass 100g of commercially available sandalwood (dry product of fertilized radish) was added with 1 part of purified water.
L was added, the mixture was heated at 100 ° C. for 2 hours, cooled and filtered. 1 L of water was further added to the residue, and the mixture was heated and extracted in the same manner. The filtrates were combined and concentrated under reduced pressure, and then freeze-dried in a vacuum to obtain 30 g of a water extract of sandalwood.

Example 2 Extract of sandalgrass To 100 g of commercially available sandalwood (a dried product of fermented radish), 1 L of a 30% ethanol aqueous solution was added, and the mixture was extracted at room temperature for 2 nights. After suction filtration, the filtrate was concentrated under reduced pressure, and subsequently freeze-dried in vacuum to obtain 13 g of an ethanol extract of sandalwood.

Example 3 Extract of sandalgrass To 100 g of commercially available sandalwood (dry product of fatted root), 1 L of 50% 1,3-butylene glycol (1,3-BG) aqueous solution was added, and the mixture was extracted at room temperature for 1 week. The residue was removed by suction filtration to obtain a 1,3-BG extract of sandalwood.

Example-4 Lotion Formulation Compounding amount 1. Ethanol 5.0 parts 2. Methyl P-oxybenzoate 0.1 3. Polyoxyethylene (40) hydrogenated castor oil 0.1 4. Perfume proper amount 5. Purified water 10.0 6. Extract (Example-1) 5.0 7.1,3-butylene glycol 3.0 8. Glycerin 2.0 9. Xanthan gum 0.02 10. Purified water 74.5 Production method: Components 1 to 5 and components 6 to 10 are uniformly dissolved and mixed. The product is then filtered.

Comparative Example-1 Conventional Lotion A conventional lotion was prepared by replacing the extract of sandalwood in Example 4 with purified water.

Example-5 Cream Formulation Amount 1. Liquid paraffin 6.5 parts 2. Vaseline 10.0 3. Stearic acid 4.0 4. Cetyl alcohol 3.0 5. Stearyl alcohol 1.0 6. Polyoxyethylene (25) monostearate 3.0 7. Sorbitan monostearate 2.5 8.1,3-Butylene glycol 5.0 9. Potassium hydroxide 0.1 10. Extract from sandalwood (Example-2) 0.2 11. Methyl P-hydroxybenzoate 0.2 12. Purified water 64.5 13. Perfume Proper amount production Method: The oil phase components 1 to 7 and the water phase components 8 to 12 are heated and dissolved at 70 to 75 ° C, respectively, and then the oil phase components 1 to 7 are added to the water phase components
Add 8 to 12 to emulsify, add component 13 during cooling, mix, and cool to 30 ° C to obtain a product.

Example-6 Emulsion formulation Formulation amount 1. Liquid paraffin 8.0 parts 2. Squalane 2.0 3. Stearyl alcohol 2.0 4. Sorbitan monooleate 2.5 5. Glycerin monostearate 2.3 6. Polyoxyethylene (10) sorbitan monooleate 0.8 7. Glycerin 6.0 8. Extract of sandgrass (Example-3) 0.5 9. Methyl P-hydroxybenzoate 0.2 10. Purified water 77.0 11. Perfume suitable amount Production method: Oil phase components 1 to 6 and aqueous phase component 7 After heating and dissolving ~ 10 to 70-75 ℃, respectively
Add 7 to 10 to emulsify, add component 11 while cooling, mix, and cool to 30 ° C to obtain a product.

Comparative Example-2 Conventional Emulsion In Example-6, the conventional emulsion was prepared by replacing the extract of sandalwood with purified water.

Example-7 Pack Formulation Amount 1. Polyvinyl alcohol 12.0 parts 2. Ethyl alcohol 5.0 3.1,3-butylene glycol 8.0 4. Methyl P-oxybenzoate 0.2 5. Polyoxyethylene (40) hydrogenated castor oil 0.5 6. Extract of sandalwood (Example-2) 1.0 7. Citric acid 0.1 8. Sodium citrate 0.3 9. Perfume 0.1 10. Purified water 73.8 Production method: Dissolve each component uniformly to obtain a product.

Example-8 Foundation Formulation Amount 1. Stearic acid 2.4 parts 2. Polyoxyethylene (20) sorbitan monostearate 1.0 3. Polyoxyethylene (20) cetyl ether 2.0 4. Cetyl alcohol 1.0 5. Liquid lanolin 2.0 6. Liquid paraffin 3.0 7. Isopropyl myristate 6.5 8. Butyl P-hydroxybenzoate 0.1 9. Purified water 58.2 10. Extract of sandalwood (Example-3) 0.5 11. Carboxymethylcellulose sodium 0.1 12. Bentonite 0.5 13 Propylene glycol 4.0 14. Triethanolamine 1.1 15. Methyl P-oxybenzoate 0.2 16. Titanium oxide 8.0 17. Talc 4.0 18. Color pigment 5.0 19. Perfume suitable amount Manufacturing method: Ingredients 10 to 13 and 15 are heated to 70 ° C. Heat to swell well. Ingredients 9 and 14 are dissolved in this to obtain an aqueous phase. Ingredients 1 to 8 are dissolved by heating and kept at 80 ° C to form an oil phase. Ingredients 16-18, which have been thoroughly mixed and passed through a grinder, are added to the aqueous phase, and the mixture is stirred with a homomixer and kept at 75 ° C. The oil phase is added to this aqueous phase while stirring and cooled, and component 19 is added at 45 ° C, and the product is cooled with stirring.

Example-9 Bath agent Formulation amount 1. Sodium sulfate 43.0 parts 2. Sodium hydrogencarbonate 50.0 3. Sandalwood extract (Example-1) 5.0 4. Yellow (202) (1) Appropriate amount 5. Perfume Appropriate amount Manufacturing method: Mix each component well to make a product.

[0018]

The extract of sandalwood of the present invention has an excellent collagen cross-linking inhibitory action, and the cosmetic characterized by containing the extract of sandalwood exhibits an excellent skin-smoothing action. Next, in order to explain the effect of the present invention in detail,
Here is an experimental example.

Experimental Example-1 Collagen Crosslinking Inhibition Test Trypsin-solubilized collagen (Type IP, Nitta Gelatin Co., Ltd.) 0.5 ml (3 mg / ml), 1M D-glucose
0.3 ml, distilled water 1.75 ml, 0.1 M phosphate buffer (pH 7.2) 0.1
5 ml and 0.3 ml of an aqueous solution of sandalgrass extract were aseptically mixed and incubated at 37 ° C for 2 weeks. A blank was prepared by replacing the aqueous solution of the extract of D-glucose and sandalwood with distilled water, and a control was prepared by replacing only the aqueous solution of the extract of sandalwood with distilled water. A positive control was prepared by adding aminoguanidine (2M), which is known as a collagen cross-linking inhibitor, instead of the aqueous solution of sandalwood extract. The Bromoyan degradation of collagen was performed by the method of Fujimoto et al. ¹⁾ . That is, after incubation, each solution was vacuum freeze-dried, followed by 70% of bromocyan (10 mg / ml).
1 ml of formic acid solution was added, and the mixture was decomposed at 20 ° C. for 3 hours. After disassembly,
After adding 9 ml of distilled water, the mixture was centrifuged at 12,000 rpm for 30 minutes to remove undecomposed substances. Subsequently, the supernatant was concentrated to dryness under reduced pressure, 1 ml of 6N hydrochloric acid was added, and the mixture was hydrolyzed at 110 ° C. for 24 hours. The amount of hydroxyproline in this hydrolyzate was measured by Woessner's method ²⁾ . The amount of solubilized collagen (relative value) by Bromian decomposition is shown in Table 1. 1) Biochemical Research 5 (3) 279-281 (1984) 2) Arch. Biochem. Biophys. 93 440-447 (1961) and below Margin

[0020]

[Table 1] Table 1 Collagen crosslinking inhibition test ───────────────────────────────── Sample working concentration * Amount of solubilized collagen ───────────────────────────────── Blank-100 Control-32 Aminoguanidine 200 mM 80 Extract (Example-1) 0.1 mg / ml 46 1.0 mg / ml 68 Extract of sandalwood (Example-2) 0.1 mg / ml 59 1.0 mg / ml 82 ──────────── ────────────────────── * Relative value when the blank is set to 100 As shown in Table 1, collagen is cross-linked by D-glucose to decompose bromocyanine. However, the cross-linking was inhibited by the extract of sandalwood.

Experimental Example-2 Skin-regulating action Using the lotion of Example-4, the emulsion of Example-6, the conventional lotion of Comparative Example-1 and the conventional emulsion of Comparative Example-2,
Targeting 15 wrinkled women (30 to 35 years old) 1
A usage test was conducted for a month. After use, the skin conditioning effect (smoothness of skin, firmness of skin, degree of improvement of wrinkles) was evaluated. As a result, the cosmetics characterized by containing the extract of sandalwood showed an excellent skin conditioning effect (Table 2).

[0022]

[Table 2] Table 2 Skin-conditioning action ───────────────────────────────── Number of people judgment ──────── ───────────────────────────────────────────────────────────────────────────────── ───────────────────────── Significantly improved 7 2 7 3 Improved 4 3 3 3 Not much improved 3 7 4 6 Not improved 13 13 ─────────────────────────────────

Using the cream of Example-5, the pack of Example-7, the foundation of Example-8 and the bath agent of Example-9 in the same manner as above, the same skin smoothing action was shown. . As described above, the extract of sandalwood of the present invention has an excellent collagen cross-linking inhibitory action, and the cosmetics characterized by containing the extract also showed an excellent skin conditioning action.

Claims (1)

[Claims] 1. A cosmetic comprising an extract of sandalwood.