JPH05155751A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having collagen crosslinking-inhibitory activity and skin trimming effect. CONSTITUTION:The objective cosmetic is characterized by containing Leonurus sibiricus extract. For example, a dried article of this plant on the market can be extracted with purified water, ethanol, 1,3-butylene glycol, propylene glycol, or a mixture thereof. This cosmetic can be used in the form of foundation, makeup cosmetic, or bathing agent.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics containing an extract of Yakusou.

[0002]

2. Description of the Related Art Wrinkles on the skin are a big problem for women,
Although many cosmetics for preventing wrinkles have been released, the fact is that the moisturizing properties of hyaluronic acid, collagen, etc. substantially extend wrinkles to prevent wrinkles, and there are few cosmetics that essentially prevent wrinkles.

[0003]

With the aging of the skin, the skin loses flexibility and elasticity, and wrinkles are formed. One of the causes of this wrinkle is cross-linking between collagen molecules formed as a result of the collagen in the dermis being non-enzymatically modified by reacting with sugar and the like. Therefore, when the application of the Yakusou extract to cosmetics was examined, it showed excellent collagen cross-linking inhibitory action and skin-smoothing action, and it was possible to formulate the present invention, thus completing the present invention.

[0004]

The present invention is a cosmetic characterized by containing an extract of Yakusou. In the present invention, Yakusou is a halibutaceae swordfish (scientific name is Leon
urus sibiricus L.), and dried products of the whole plant that are commercially available can be used.

The extract of Yakusou, for example, is obtained by adding a single or mixed solvent of water, ethanol, 1,3-butylene glycol, propylene glycol or the like to a dried product of Yakusou and extracting it by a conventional method at room temperature or by heating. You can The extract of Yakusou can be concentrated or concentrated to dryness, if necessary, in order to facilitate subsequent operations. If necessary, the polysaccharide contained in the extract can be removed by precipitation by refrigeration or the like.

The Yakusou extract is 0.0001 to 10% by weight, preferably 0.1% by weight of the total amount of the cosmetic of the present invention as a dry solid.
It is possible to add 01 to 5.0% by weight. At a concentration of 0.0001% or less, a sufficient effect cannot be obtained, and at a concentration of 10% by weight or more, the effect is not enhanced and it is uneconomical. In the cosmetics of the present invention, oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, surfactants and the like used in cosmetics, etc., within a range that does not impair the effects of Yakusou extract The raw materials can be mixed. As the cosmetic of the present invention, basic cosmetics such as creams, lotions, milky lotions, and packs, makeup cosmetics such as foundations and lipsticks, bath agents, and soaps can be used.

[0007]

EXAMPLES Next, examples will be given to explain the present invention in detail, but the present invention is not limited thereto. still,
The parts of the compounding amounts shown in the examples are parts by weight. Example-1 Yakuso extract: 100 g of commercially available Yakuso (dried whole grass) with 1 L of purified water
In addition, the mixture was heated at 100 ° C. for 2 hours, cooled and filtered. 1 L of water was further added to the residue, and heat extraction was performed in the same manner. The filtrates were combined and concentrated under reduced pressure, and then vacuum freeze-dried to obtain 30 g of a water extract of Yakuso.

Example-2 Yakuso extract: To 100 g of commercially available Yakuso (whole grass), 1 L of a 30% aqueous ethanol solution was added, and the mixture was extracted at room temperature for 2 nights. After suction filtration, the filtrate was concentrated under reduced pressure, and subsequently vacuum freeze-dried to obtain 15 g of an ethanol extract of Yakusou.

Example 3 Yakuso extract: To 100 g of commercially available Yakuso (whole grass), 1 L of 50% 1,3-butylene glycol (1,3-BG) aqueous solution was added, and the mixture was mixed at room temperature for 1 hour.
Extracted for a week. The residue was removed by suction filtration to obtain a 1,3-BG extract of Yakusou.

Example-4 Lotion Formulation Compounding amount 1. Ethanol 5.0 parts 2. Methyl P-oxybenzoate 0.1 3. Polyoxyethylene (40) hydrogenated castor oil 0.1 4. Perfume proper amount 5. Purified water 10.0 6. Yakusou Extract (Example-1) 5.0 7.1,3-butylene glycol 3.0 8. Glycerin 2.0 9. Xanthan gum 0.02 10. Purified water 74.5 Production method: Components 1 to 5 and components 6 to 10 are uniformly dissolved and mixed. Then filter to obtain the product.

Comparative Example-1 Conventional Lotion A conventional lotion was prepared in the same manner as in Example 4, except that the extract of Yakuso was replaced with purified water.

Example-5 Cream Formulation Amount 1. Stearic acid 4.0 parts 2. Cetyl alcohol 3.0 3. Stearyl alcohol 1.0 4. Liquid paraffin 6.5 5. Vaseline 10.0 6. Sorbitan monostearate 2.5 7. Polyoxyethylene (25 ) Monostearate 3.0 8.1,3-Butylene glycol 5.0 9. Potassium hydroxide 0.1 10. Yakusou extract (Example-2) 0.2 11. Methyl P-hydroxybenzoate 0.2 12. Purified water 64.5 13. Perfume proper quantity production Method: The oil phase components 1 to 7 and the water phase components 8 to 12 are heated and dissolved at 70 to 75 ° C, respectively, and then the oil phase components 1 to 7 are added to the water phase components.
Add 8 to 12 to emulsify, add component 13 during cooling, mix, and cool to 30 ° C to obtain a product.

Example-6 Emulsion Formulation Amount 1. Stearic acid 2.0 parts 2. Stearyl alcohol 2.0 3. Liquid paraffin 8.0 4. Glycerin monostearate 2.3 5. Sorbitan monooleate 2.5 6. Polyoxyethylene (10) sorbitan mono Olate 0.8 7. Glycerin 6.0 8. Yakusou extract (Example-3) 0.5 9. Methyl P-hydroxybenzoate 0.2 10. Purified water 77.0 11. Perfume suitable amount Production method: a product similar to Example-5 To do.

Comparative Example-2 Conventional Emulsion In Example-6, a conventional emulsion was prepared by substituting the extract of Yakusou for.

Example-7 Pack Formulation Amount 1. Polyvinyl alcohol 12.0 parts 2. Ethyl alcohol 5.0 3.1,3-butylene glycol 8.0 4. Methyl P-oxybenzoate 0.2 5. Polyoxyethylene (40) hydrogenated castor oil 0.5 6. Yakusou extract (Example-2) 1.0 7. Citric acid 0.1 8. Sodium citrate 0.3 9. Perfume proper amount 10. Purified water 73.8 Manufacturing method: Dissolve each component uniformly to obtain a product.

Example-8 Foundation Formulation Amount 1. Yakusou extract (Example-3) 0.5 part 2. Stearic acid 2.4 3. Polyoxyethylene (20) sorbitan monostearate 1.0 4. Polyoxyethylene (20) ) Cetyl ether 2.0 5. Cetyl alcohol 1.0 6. Liquid lanolin 2.0 7. Liquid paraffin 3.0 8. Isopropyl myristate 6.5 9. Butyl P-hydroxybenzoate 0.1 10. Purified water 58.2 11. Sodium carboxymethylcellulose 0.1 12. Bentonite 0.5 13 Propylene glycol 4.0 14. Triethanolamine 1.1 15. P-Methyl oxybenzoate 0.2 16. Titanium oxide 8.0 17. Talc 4.0 18. Color pigment 5.0 19. Fragrance suitable amount Manufacturing method: Components 1 and 15 are heated to 70 ° C. Swell component 11 well. To this, component 10 in which component 12 is dispersed is added and dissolved, and then components 13 and 14 are dissolved to form an aqueous phase.
Ingredients 2-9 are melted by heating and kept at 80 ° C to form an oil phase. To the aqueous phase, add components 16 to 18 that have been thoroughly mixed and ground through a grinder, and stir with a homomixer to keep at 75 ° C. Add the oil phase to this aqueous phase while stirring, cool and add component 19 at 45 ° C,
The product is made after stirring and cooling.

Example-9 Formulation of bath agent 1. Sodium sulfate 43.0 parts 2. Sodium hydrogen carbonate 50.0 3. Yakuso extract (Example-1) 5.0 4. Yellow No. 202 (1) proper amount 5. Fragrance Appropriate amount Manufacturing method: Mix each component well to make a product.

[0018]

EFFECTS OF THE INVENTION The Yakuso extract of the present invention has an excellent collagen cross-linking inhibitory action, and the cosmetic characterized by containing the Yakuso extract has an excellent skin conditioning action. Next, in order to explain the effect of the present invention in detail,
Here is an experimental example.

Experimental Example-1 Collagen Crosslinking Inhibition Test Trypsin-solubilized collagen (Type IP, Nitta Gelatin Co., Ltd.) 0.5 ml (3 mg / ml), 1M D-ribose 0.3
ml, distilled water 1.75 ml, 0.1 M phosphate buffer (pH 7.2) 0.15 ml
And 0.3 ml of an aqueous solution of the extract of Yakusou was mixed aseptically and incubated at 37 ° C. for 2 weeks. A blank was prepared by replacing the aqueous solution of D-ribose and Yakusou extract with distilled water, and a control was prepared by replacing only the aqueous solution of Yakusou extract with distilled water. A positive control was prepared by adding aminoguanidine (2M), which is known as a collagen cross-linking inhibitor, in place of the aqueous solution of Yakuso extract. Bromoyan degradation of collagen was performed by the method of Fujimoto et al. ¹⁾ . That is, after the incubation, each solution was vacuum freeze-dried, and then 1 ml of 70% formic acid solution of bromocyan (10 mg / ml) was added and decomposed at 20 ° C. for 3 hours. After the decomposition, 9 ml of distilled water was added, followed by centrifugation at 12,000 rpm for 30 minutes to remove undecomposed substances. Subsequently, this supernatant was concentrated under reduced pressure to dryness, 1 ml of 6N hydrochloric acid was added, and the mixture was hydrolyzed at 110 ° C. for 24 hours. The amount of hydroxyproline in this hydrolyzate is Woes
It was measured by sner's method ²⁾ . Table 1 shows the amount of collagen (relative value) solubilized by Bromocyan decomposition. 1) Biochemical Research 5 (3) 279-281 (1984) 2) Arch. Biochem. Biophys. 93 440-447 (1961) Margins below

[0020]

[Table 1] Table 1 Collagen cross-linking inhibition test ───────────────────────────────── Sample working concentration * Amount of solubilized collagen ───────────────────────────────── Blank-100 Control-43 Aminoguanidine 200 mM 80 Yakusou Extract (Example-1) 0.1 mg / ml 56 1.0 mg / ml 72 Yakusou extract (Example-2) 0.1 mg / ml 62 1.0 mg / ml 82 ───────────── ────────────────────── * Relative value when blank is set to 100 As shown in Table 1, collagen is cross-linked by D-ribose to decompose bromocyanine. However, the cross-linking was inhibited by the extract of Yakusou.

Experimental Example-2 Skin-regulating action Using the lotion of Example-4, the emulsion of Example-6, the conventional lotion of Comparative Example-1 and the conventional emulsion of Comparative Example-2,
Targeting 15 wrinkled women (30 to 35 years old) 1
A usage test was conducted for a month. After use, the skin conditioning effect (smoothness of skin, firmness of skin, degree of improvement of wrinkles) was evaluated. As a result, the cosmetics characterized by containing the extract of Yakusou showed an excellent skin conditioning effect (Table 2).

[0022]

[Table 2] Table 2 Skin-conditioning action ──────────────────────────────── Number of people judgment ──────── ─────────────────────────────────────────────────────────────────────────────── ───────────────────────── Significantly improved 6 3 7 2 Improved 5 3 3 3 Not much improved 3 5 4 7 Not improved 1 4 1 3 ─────────────────────────────────

Using the cream of Example-5, the pack of Example-7, the foundation of Example-8 and the bath preparation of Example-9 in the same manner as above, the same use test was conducted, and it showed an excellent skin-conditioning action. .. As described above, the extract of Yakusou of the present invention had an excellent collagen cross-linking inhibitory action, and the cosmetics characterized by containing the extract showed an excellent skin conditioning action.

Claims (1)

[Claims] 1. A cosmetic comprising an extract of Yakusou.