JP2000044460A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly safe skin preparation for external use, having both an excellent beautifully whitening action and a skin aging-preventing action, capable of imparting a comprehensive beatifying effect to skin and scarcely irritating the skin. SOLUTION: This skin preparation for external use contains the hydrolysate of a rice extract and one or more kinds of beautifully whitening agents selected from kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, a placenta extract, a white mulberry root bark extract and a Saxifraga stolonifera extract.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which has both excellent whitening action and anti-aging effect on the skin, can give a comprehensive cosmetic effect to the skin, and is less irritating to the skin and highly safe. .

[0002]

2. Description of the Related Art Various whitening agents such as kojic acid, ascorbic acid derivatives and hydroquinone derivatives have been conventionally proposed for the purpose of preventing pigmentation caused by sunburn or aging, especially spots and freckles, and improving symptoms. An external preparation for skin containing is marketed. However,
When these conventional whitening agents are added to a concentration at which the whitening effect can be sufficiently exhibited, a problem may occur in terms of toxicity (skin irritation). Have difficulty. In recent years, active ingredients for external preparations for the skin have been required not only for whitening, but also for preventing skin aging or improving moisturizing properties and contributing to overall soundness and health of the skin. However, it is naturally difficult to respond to such a demand with a conventional whitening agent.

[0003]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems of the prior art, and an object of the present invention is to use an existing whitening agent at a high concentration where its effect can be effectively exhibited. It is an object of the present invention to provide an external preparation for skin comprising an improved formulation that exhibits less toxicity (skin irritation) even when it is mixed.

[0004] Another object of the present invention is to provide a highly safe external preparation for skin which has both a whitening effect and an effect of preventing skin aging, is hypoallergenic, and can impart a comprehensive cosmetic effect to the skin. Is to do.

[0005]

That is, the present invention relates to a hydrolyzate of rice extract and kojic acid and its derivatives, arbutin, ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, soybean extract, and saxifrage extract. And an external preparation for skin prepared by blending one or more whitening agents selected from placental extracts.

According to the external preparation for skin of the present invention comprising the above-mentioned hydrolyzate of rice extract and a whitening agent in combination, the whitening agent is blended to a concentration at which its original effect is maximized. In addition, the expression of skin irritation is suppressed, the safety is greatly improved, and the skin whitening effect inherent to the whitening agent and the anti-aging effect of the rice extract hydrolyzate are combined, resulting in a comprehensive A beautiful cosmetic effect is provided.

Hereinafter, the present invention will be described in detail. The rice extract hydrolyzate used in the present invention is mainly composed of oligopeptides and amino acids obtained by hydrolyzing an extract obtained by extracting rice with a solvent such as water or alcohol, using an acid, an alkali or an enzyme. A composition. There is no particular limitation on the rice used here, but in general, polished rice is preferable, and it is better to subject the rice to extraction without crushing or powdering.
It is preferable because the amount of starch is small and subsequent operations are easy.

Solvents used for the extraction include water, alcohols such as methanol and ethanol, polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin, ethyl acetate, and the like.
There are esters such as butyl acetate and methyl propionate, ketones such as acetone and methyl ethyl ketone, ethers such as ethyl ether and isopropyl ether, and hydrocarbon solvents such as hexane, toluene and chloroform. Or after adjusting the pH with an acid or an alkali. Among them, in the present invention, it is preferable to use water or a mixed solution of water and alcohols, or water and polyhydric alcohols, and particularly to use them with alkali at a pH of 7.5 to 14, particularly 9 to 12. Most preferred is the use of an alkaline aqueous medium adjusted to.

The extraction temperature and time vary depending on the solvent used and the like, but are generally about 4 hours to 40 ° C. for about 6 hours to 7 days. When the above-mentioned alkaline aqueous medium is used, the extraction temperature is 4 to 30 ° C. for 12 hours. ~ 36 hours is preferred.

The hydrolysis of the rice extract obtained here is
The reaction is carried out using an acid, an alkali or an enzyme. Above all, decomposition by an enzyme is preferred from the viewpoint of uniformity of the quality of the product, ease of process control, and the like. In the case of acid hydrolysis,
As the acid, use hydrochloric acid, sulfuric acid, etc., and adjust the pH of the extract to 5
In the following, the temperature is particularly set to 4 or less, and heating may be performed at 60 to 90 ° C. for 1 to 6 hours. In the case of alkaline hydrolysis,
Generally, the pH of the extract is adjusted to 9 to 13 using caustic soda, caustic potash, sodium carbonate, or the like, and heat treatment is generally performed at 60 to 90 ° C for 1 to 6 hours.

In the case of enzymatic hydrolysis, the enzymes used include actinases, pepsins such as pepsin, and the like.
Trypsin such as trypsin, papain, papains such as chymopapain, glycylglycine peptidase,
Examples include peptidases such as carboxypeptidase and aminopeptidase, and bromelain, and these are usually used in combination of two or more. When enzymes are used in combination, the combination of actinase and pepsin or trypsin is most preferred.

In the hydrolysis treatment with these enzymes, the enzymes are usually added in an amount of 0.0005 to 100 parts by weight of the rice extract.
The reaction is carried out by using 0.05 part by weight, preferably 0.001 to 0.005 part by weight, of the enzyme used under conditions near the optimum pH and the optimum temperature for 1 to 24 hours.

[0013] The obtained rice extract hydrolyzate solution is generally adjusted to pH 4 to 8, and then used as it is or after being further adjusted to an appropriate concentration by concentration. Powdered and used according to a conventional method such as a spray drying method and a freeze drying method.

In the present invention, the kojic acid derivative in the whitening agent used in combination with the above-mentioned rice extract hydrolyzate includes:
For example, kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, and kojic acid dibutyrate, or kojic acid ethers, as an ascorbic acid derivative, for example, L-ascorbic acid-2-phosphate Ester salts, ascorbic acid ester salts such as L-ascorbic acid-2-sulfate (salts are sodium salts, magnesium salts, etc.), L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L) -Ascorbic acid) and L-ascorbic acid-5-glucoside (5-O-α-D-glucopyranosyl-L-ascorbic acid), ascorbic acid sugar derivatives, and resorcinol derivatives such as 4-n
-Butyl resorcinol, 4-isoamyl resorcinol and the like. In addition, as the extract of Sophora oleracea, the extract of Saxifraga and the extract of placenta, those of cosmetic compounding grades listed in the official Japanese standard for cosmetics can be suitably used.

Among these whitening agents, especially kojic acid,
When arbutin, L-ascorbic acid-2-phosphate ester magnesium salt or L-ascorbic acid-2-glucoside is used in combination with a hydrolyzate of rice extract, the irritation of these whitening agents is reduced, resulting in high safety. Not only that cosmetics can be provided, but also a comprehensive cosmetic effect based on the combined use of both components is remarkably exhibited, which is preferable.

The compounding ratio of the hydrolyzate of rice extract to the above-mentioned whitening agent is generally in the range of 20: 1 to 1:20, preferably 10: 1 to 1:10, particularly preferably 10: 1 to 1:10 in terms of solid content. Is in the range of 5: 1 to 1: 5. When the blending ratio of the whitening agent to the rice extract hydrolyzate exceeds 1:20, the effect of reducing the irritation of the whitening agent by the rice extract hydrolyzate becomes insufficient. And it becomes difficult to obtain a comprehensive cosmetic effect.

The amount of the hydrolyzate of rice extract and the whitening agent in the external preparation for skin of the present invention is within the above range.
In the case of rice extract hydrolyzate, it is generally 0.00
It is in the range of from 0.5 to 5% by weight, preferably from 0.005 to 1% by weight, and in the case of whitening agents generally from 0.1 to 10% by weight, preferably from 0.5 to 5% by weight. If the amount is less than the above range, it is difficult to obtain a sufficient whitening / skinning effect, whereas if the amount exceeds the above range, not only the cosmetic effect is not further improved but also a whitening agent. In some cases, it is difficult to suppress skin irritation based on the skin irritation.

The external preparation for skin of the present invention can be used as any of cosmetics, quasi-drugs, and medicaments. Its dosage form is, for example, cream, emulsion, lotion, ointment,
Appropriate materials such as packs and cataplasms can be adopted according to the intended use and the application object.

The external preparation for skin of the present invention includes, in addition to the essential components, hydrolyzate of rice extract and whitening agent, oily components, surfactants, moisturizers, thickeners, and preservatives which are usually used in external preparations for skin. A bactericide, a powder component, an ultraviolet absorber, a dye, a fragrance and the like are appropriately compounded as required.

Here, as the oily component, olive oil,
Oils such as jojoba oil, castor oil, soybean oil, coconut oil, palm oil, cacao oil, mink oil, turtle oil; waxes such as beeswax, carnauba wax, lanolin; liquid paraffin;
Hydrocarbons such as petrolatum, paraffin wax and squalane; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid and isostearic acid; higher alcohols such as lauryl alcohol and cetanol stearyl alcohol; isopropyl myristate and isopropyl palmitate And synthetic esters such as butyl oleate.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. Nonionic surfactants such as fatty acid esters of polyoxyethylene sorbitol, fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates Polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates, etc. On surfactant; quaternary ammonium salts, primary to tertiary fatty amine salts, trialkyl benzyl ammonium salts, alkyl pyridinium salts, 2
Cationic surfactants such as -alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N, N-dialkylmorphonium salts and polyethylenepolyamine fatty acid amide salts; N, N-dimethyl-N-alkyl-N
-Carboxymethylammoniobetaine, N, N, N-
Zwitterionic surfactants such as trialkyl-N-alkyleneammoniocarboxybetaine and N-acylamidopropyl-N'N'-dimethyl-N'-β-hydroxypropylammoniosulfobetaine are exemplified.

Examples of humectants include glycerin, propylene glycol, dipropylene glycol, 1,3-
Butylene glycol, polyethylene glycol, sorbitol, xylitol, pyrrolidone carboxylate and the like.

Examples of the thickener include tragacanth gum,
Examples include sodium alginate, pectin, sodium carboxymethylcellulose, polyvinyl alcohol, polyacrylic acid and derivatives thereof, carboxyvinyl polymer, gelatin, polyvinylpyrrolidone, veegum, methylpolysiloxane, dextran and the like.

Examples of the antiseptic disinfectant include urea, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate,
Phenoxyethanol, dichlorophen, hexachlorophen, chlorhexidine hydrochloride, benzalkonium chloride, salicylic acid, ethanol and the like.

Examples of the powder component include titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, silk powder and the like.

Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate, ethylhexyl paramethoxycinnamate, octyl cinnamate, 2,4-dihydroxybenzophenone and 2-hydroxy-4-methoxybenzophenone-. 5-sulfonic acid salt, 2- (2-hydroxy-5-
Methylphenyl) benzotriazole, urocanic acid,
And ethyl urocanate.

The skin external preparation of the present invention may further contain a skin active ingredient as long as the effectiveness of the combination component of the present invention is not impaired. Examples thereof include vitamin E derivatives such as vitamin E nicotinate and vitamin E linoleate; diisopropylamine dichloroacetate; γ-amino-β-hydroxybutyric acid; citric acid;
α-hydroxy acids such as α-hydroxyoctanoic acid; crude drug extracts such as gentian extract;

Next, the present invention will be described more specifically with reference to Production Examples, Examples and Test Examples, but the present invention is not limited thereto. In the following, parts mean parts by weight.

Production Example 1 Preparation of Rice Extract Hydrolyzate Solution 100 g of polished rice was immersed in 400 ml of 0.25 N aqueous sodium hydroxide at room temperature for 24 hours. Next, insoluble materials were removed by filtration, and the filtrate was sequentially treated with actinase, pepsin and trypsin. Enzyme treatment is 5m for each enzyme
g at the optimum pH of each enzyme and at 40 ° C for 2 hours.
Performed by holding for a time. The obtained enzyme-treated solution was filtered to obtain a pale yellow transparent rice extract hydrolyzate solution (solid content: about 0.5% by weight, weight average molecular weight: 2).
250 ml).

Production Example 2 Preparation of Rice Extract Hydrolyzate Solution A rice extract hydrolyzate solution (solid content: about 0.5% by weight) was prepared in the same manner as in Production Example 1 except that papain was used instead of pepsin as an enzyme. %, Weight average molecular weight: 2500 or less) ml.

Production Example 3 Preparation of Rice Extract Hydrolyzate Solution 100 g of polished rice was immersed in 400 ml of 0.25 N aqueous sodium hydroxide at room temperature for 24 hours. Next, the insolubles were removed by filtration, and the filtrate was adjusted to pH 10 with a 2N aqueous sodium hydroxide solution, and then kept at 80 ° C. for 2 hours. The treatment liquid obtained here was filtered to obtain 200 ml of a pale yellow transparent rice extract hydrolyzate solution (solid content: about 1.5% by weight, weight average molecular weight: 2500 or less).

Preparation Example 4 Preparation of Rice Extract Hydrolyzate Powder 200 ml of the rice extract hydrolyzate solution prepared in the same manner as in Preparation Example 1 was freeze-dried to obtain about 1.0 g of the rice extract hydrolyzate powder. Was.

Example 1 Cream [Component A] Part Liquid paraffin 5.0 Hexalan (Glyceryl trioctanoate manufactured by Technoble Co., Ltd.) 4.0 Paraffin 5.0 Glyceryl monostearate 2.0 Polyoxyethylene (20) sorbitan Monostearate 6.0 butyl paraben 0.1 [Component B] Hydrolyzate solution of rice extract of Production Example 1 20.0 Kojic acid 2.0 Glycerin 5.0 Carboxymethyl monostearate 0.1 Methyl paraben 0.1 Moiston C (NMF component, manufactured by Technoble Co., Ltd.) 1.0 Amount of purified water to make the total amount 100 parts [Component C] Fragrance Appropriate amount After heating the above components A and B to 80 ° C. or higher, respectively, mix Stirred. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare a cream.

Example 2 Emulsion [Component A] liquid paraffin 6.0 hexalane (glyceryl trioctanoate manufactured by Technoble Co., Ltd.) 4.0 jojoba oil 1.0 polyoxyethylene (20) sorbitan monostearate 2.0 Soybean lecithin 1.5 Methyl paraben 0.15 Ethyl paraben 0.03 [Component B] Hydrolyzate solution of rice extract of Production Example 2 25.0 Kojic acid 2.0 Glycerin 3.0 1,3-butylene glycol 2.0 Carboxymethylcellulose 0.3 Sodium hyaluronate 0.01 Purified water Amount to make the total amount 100 parts [Component C] Fragrance Appropriate amount After heating each of the above components A and B to 80 ° C. or higher, they were mixed and stirred. After cooling to 50 ° C., the C component was added and further stirred and mixed to prepare an emulsion.

Example 3 Lotion [Components] Part Hydrolyzate solution of rice extract of Production Example 1 15.0 Arbutin 2.0 Ethanol 10.0 Glycerin 3.0 1,3-butylene glycol 2.0 Methylparaben 0.2 Citric acid 0.1 Sodium citrate 0.3 Carboxyvinyl polymer 0.1 Perfume Appropriate amount Purified water An amount that gives a total amount of 100 parts The above components were mixed to prepare a lotion.

Example 4 Pack [Components] Part Polyvinyl alcohol 15.0 Hydroxymethylcellulose 5.0 Propylene glycol 5.0 Ethanol 10.0 Methylparaben 0.2 Rice extract hydrolyzate powder of Production Example 4 1.0 L- Ascorbic acid-2-phosphate ester magnesium salt 2.0 Perfume Appropriate amount Purified water Amount to make the total amount 100 parts The above components were mixed to prepare a pack.

Example 5 Cream A cream was prepared in the same manner as in Example 1 except that 2.0 parts of arbutin was used instead of 2.0 parts of kojic acid.

Example 6 Cream In Example 1, magnesium salt of L-ascorbic acid-2-phosphate was used instead of 2.0 parts of kojic acid.
A cream was prepared in the same manner as in Example 1 except that 0 part was used.

Example 7 Cream A cream was prepared in the same manner as in Example 1 except that 2.0 parts of L-ascorbic acid-2-glucoside was used instead of 2.0 parts of kojic acid. .

Example 8 Cream In Example 1, 4-n was used in place of 2.0 parts of kojic acid.
A cream was prepared in the same manner as in Example 1 except that 2.0 parts of -butylresorcinol was used.

Example 9 Cream A cream was prepared in the same manner as in Example 1 except that 2.0 parts of ellagic acid was used instead of 2.0 parts of kojic acid.

Example 10 Cream A cream was prepared in the same manner as in Example 1 except that 2.0 parts of placental extract was used instead of 2.0 parts of kojic acid.

Example 11 Cream In Example 1, 2.0 parts of L-ascorbic acid-2-glucoside was replaced with 2.0 parts of kojic acid and gentian extract (Infran AT, manufactured by Technoble Co., Ltd.). A cream was prepared in the same manner as in Example 1 except that 1.0 part of a solid content (2.3% by weight) was used.

Comparative Example 1 Cream Same as Example 1 except that kojic acid (2.0 parts) was used alone in place of the hydrolyzate of rice extract and kojic acid in preparing the cream of Example 1. To prepare a cream.

Comparative Example 2 Cream The preparation of the cream of Example 5 was carried out in the same manner as in Example 5 except that arbutin (2.0 parts) was used alone instead of the hydrolyzate of rice extract and arbutin. A cream was prepared.

Comparative Example 3 Cream In the preparation of the cream of Example 6, instead of the hydrolyzate of rice extract and magnesium L-ascorbic acid-2-phosphate ester, L-ascorbic acid-2-phosphate was used. A cream was prepared in the same manner as in Example 6, except that the ester magnesium salt (2.0 parts) was used alone.

Comparative Example 4 Cream In the preparation of the cream of Example 7, instead of the hydrolyzate of rice extract and L-ascorbic acid-2-glucoside,
A cream was prepared in the same manner as in Example 7, except that L-ascorbic acid-2-glucoside (2.0 parts) was used alone.

Comparative Example 5 Cream In the preparation of the cream of Example 8, 4-n-butylresorcinol was used instead of the rice extract hydrolyzate and 4-n-butylresorcinol.
A cream was prepared in the same manner as in Example 8, except that -butylresorcinol (2.0 parts) was used alone.

Comparative Example 6 Cream Same as Example 9 except that ellagic acid (2.0 parts) was used alone in place of the hydrolyzate of rice extract and ellagic acid in preparing the cream of Example 9. To prepare a cream.

Comparative Example 7 Cream In the preparation of the cream of Example 10, placenta extract (2.0 parts) was used in place of the rice extract hydrolyzate and placenta extract.
A cream was prepared in the same manner as in Example 10 except for using the cream alone.

Test Example 1 Irritation Evaluation Test Each sample was evaluated for irritation by a neutral red uptake test using cultured rabbit corneal cells (SIRC), which is an alternative method to the ocular mucosal irritation test.

[Test Method] After 5,000 SIRCs were seeded on a 96-well microplate and cultured for 3 days in Eagle's minimum essential medium (MEM) containing 5% calf serum, each sample was subjected to the concentration shown in Table 1 below. And cultivated for another 2 days. Next, SRIC was cultured in Eagle MEM medium containing 0.05% neutral red (NR) for 3 hours,
The NR uptake rate of the obtained SRIC was determined, and the irritancy of each sample was evaluated.

[Table 1]

In Table 1, OH, KA, AL, AP
M, AG, EA, BR and PE mean the following. OH: hydrolyzate of rice extract of Production Example 1, KA: kojic acid, AL: arbutin APM: L-ascorbic acid-2
-Magnesium phosphate salt, AG: L-ascorbic acid-2-glucoside, EA: ellagic acid, BR: 4-
n-butyl resorcinol, PE: placenta extract

[Results] The results are shown in Table 2.

[Table 2]

As shown in Table 2, the sample obtained by combining the existing whitening agent with the hydrolyzate of the rice extract has an extremely high NR uptake ratio as compared with the case of using the whitening agent alone. The formulated external preparation for skin becomes highly safe with irritation suppressed by a whitening agent.

Test Example 2 Monitor Test The cosmetics of Examples 1, 5, 6, and 7 and Comparative Examples 1, 2, 3, and 4 were subjected to a monitor test by the method described below to evaluate the effectiveness.

[Monitor Test] Thirty women, aged 18 to 55 years, randomly selected as subjects were treated with each cosmetic,
Apply twice daily (morning and evening) to the cheeks of the face for one month, and then apply the applied area to the effect of improving spots and freckles (whitening effect), the effect of improving fine wrinkles, and the effect of reducing the variation in the area between keratinocytes. Was evaluated based on the following evaluation criteria.

[Evaluation Criteria] (Whitening effect) A: The condition of stains and freckles was greatly improved. B: The condition of stains and freckles was slightly improved. C: No change. D: The condition of stains and freckles was slightly poor. E: The condition of spots and freckles became very bad (effect on fine wrinkles) A: Almost disappeared B: Less noticeable C: No change D: Increased slightly E: Increased

(Reduction Effect on Variation in Area between Keratinocytes) Thirty cells on the left cheek of the face of the panel were
Using a double-sided paper tape (manufactured by Nystack Co., Ltd., Nichiban Co., Ltd.), the keratinocytes were separated by a tape stripping method, and the area of each cell was measured. The standard deviation was calculated for the obtained cell area, and evaluated according to the following criteria. A: Standard deviation decreased by 50% B: Standard deviation decreased by 25% C: No change D: Standard deviation increased by 25% E: Standard deviation increased by 50%

[Results] The results are shown in Table 3.

[Table 3]

As shown in Table 3, the cream containing the hydrolyzate of rice extract of the present invention and a whitening agent has an excellent whitening effect, improves fine wrinkles, and reduces the area between keratinocytes. As seen in miniaturization, it also has skin aging prevention effects such as activation of skin cells and normalization of turnover, and it can give the skin a comprehensive cosmetic effect that is difficult with a cream containing only a whitening agent it can. Example 8
The same monitor test as described above was carried out on the cosmetics of Nos. 9, 10 and 11, and all of them gave the same excellent cosmetic effects as the cosmetics of the examples shown in Table 3 and had little skin irritation. Was something.

[0062]

The skin external preparation of the present invention comprising a whitening agent such as kojic acid and arbutin in combination with a hydrolyzate of rice extract is characterized in that the skin irritating property of the whitening agent is higher than that of rice extract by hydrolysis. As a result, the irritation to the skin is reduced and the safety is extremely high. In addition, due to the combination effect of the whitening agent and the hydrolyzate of rice extract having an antiaging effect on the skin, the external preparation for skin of the present invention imparts a comprehensive cosmetic effect to the skin, and makes the skin beautiful and young. It is kept in a healthy state.

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Claims (4)

[Claims] 1. A whitening agent selected from a hydrolyzate of rice extract and kojic acid and its derivatives, arbutin ascorbic acid and its derivatives, ellagic acid, resorcinol derivatives, placenta extract, soybean extract, and yukinoshita extract.
An external preparation for skin comprising a mixture of two or more species. 2. The external preparation for skin according to claim 1, wherein the hydrolyzate of the rice extract is obtained by treating an alkaline extract of rice with two or more proteases. 3. The method according to claim 1, wherein the protease is a combination of (a) actinase and (b) one or more selected from the group consisting of pepsins, trypsins, papains, peptidases and bromelain. Item 3. An external preparation for skin according to item 2. 4. A whitening agent comprising kojic acid, arbutin, L-ascorbic acid-2-phosphate magnesium salt,
-Ascorbic acid-2-glucoside, ellagic acid and 4-
The external preparation for skin according to claim 1, wherein the external preparation is selected from n-butyl resorcinol, an extract of somaria, and an extract of saxifrage.