JP2019019100A - Skin Cosmetic - Google Patents

Abstract

To provide a skin cosmetic that improves dry skin and resulting rough skin and reduces fine wrinkles and improves skin resilience and firmness, and has little stickiness after application.SOLUTION: A skin cosmetic contains the following components (A)-(C): (A) melon placenta extract; (B) one or more selected from hyaluronic acid and salt thereof, collagen hydrolysate, and ceramide; and (C) one or more selected from retinol and derivative thereof, royal jelly extract, and Scutellaria root extract.SELECTED DRAWING: None

Description

The present invention relates to skin cosmetics, and in particular, improves skin dryness and accompanying skin, reduces fine lines, improves skin firmness and elasticity, and is excellent in use feeling with less stickiness after application. Relates to skin cosmetics.

Common signs of skin aging include rough skin with dry skin and accompanying exfoliation of corneocytes, wrinkles due to skin firmness and reduced elasticity, and tarmi. In particular, these phenomena formed in the eyes and mouth are factors that significantly impress facial aging. Inhibiting and improving these complex signs of aging is extremely important as a care for preventing various skin conditions that are cosmetically undesirable.

In order to prevent these signs of aging, various methods and cosmetics have been proposed.For example, a method for supplementing the skin barrier function using a moisturizing ingredient, a component for improving the skin function, and the skin function are added. The method of improving gradually is mentioned. As a method of supplementing the skin barrier function by the moisturizing component, for example, a highly hydrating moisturizing component such as a polyhydric alcohol or a saccharide, and a skin occlusive oil component such as liquid paraffin or ester oil are blended. It is common practice to adjust the amount. However, although all of the above prior arts have a certain effect as a skin cosmetic for the purpose of improving rough skin, any method for supplementing the skin barrier function with a moisturizing component has the ability to retain skin moisture (moisturizing after a certain period of time). (Effectiveness) is not sufficient, and the keratin-improving effect is also small. In addition, when an occlusive agent with an oil agent is used, there are drawbacks such as the oily and sticky feeling after application, and it is more effective. In order to exert a certain effect, a large amount of moisturizing ingredients and oils must be blended, and as a result, there are many sticky feelings overall, and the user's satisfaction in the feeling after application was not obtained. .

Moreover, as a method for improving skin function itself, rather than enhancing skin occlusiveness with cosmetics, for example, by combining various plant extracts, the production and / or release of stem cell factor is suppressed to improve rough skin. An external preparation for skin (for example, see Patent Document 1) has been proposed. However, external preparations for skin that suppress the production and / or release of these stem cell factors can improve skin roughness with long-term use, but they can cause various signs of aging such as improvement of fine wrinkles and elasticity and elasticity of the skin. It did not have a deterrent / improvement effect.

Further, for the purpose of reducing stickiness at the time of application and improving the sustainability of the moisturizing effect, a skin external preparation (for example, see Patent Document 2) combining polyoxyethylene coconut oil fatty acid glycerin and mucopolysaccharide containing hyaluronic acid has been proposed. ing. However, the topical skin preparation combined with polyoxyethylene coconut oil fatty acid glycerin and mucopolysaccharide containing hyaluronic acid has a moisturizing effect for a long time and reduces stickiness at the time of application. As with cosmetics that suppress the production and / or release of stem cell factor to improve rough skin, the combination did not suppress or improve various signs of aging such as fine wrinkles and skin firmness and elasticity. .

On the other hand, as a skin external preparation for suppressing and improving various signs of aging, a skin external preparation characterized by containing a phosphate diester complex of α-hydroxy acid and retinol (see, for example, Patent Document 3), Skin cosmetics containing an extract from peeled mask melon (see, for example, Patent Document 4), a topical skin extract containing a placenta extract of a grass family plant (see, for example, Patent Document 5) ) Has been proposed. However, a topical skin preparation characterized by containing a phosphoric acid diester complex of α-hydroxy acid and retinol has an effect of improving wrinkles and increasing skin elasticity, but has a long-lasting moisturizing effect. Skin cosmetics that do not have sufficient skin improvement effects or that contain an extract from peeled mask melon have wrinkle improvement, increased skin elasticity, and a long-lasting moisturizing effect. A topical skin preparation that does not have sufficient improvement effects or contains a placenta extract of a gramineous plant has an improvement effect on skin and an increase in skin elasticity, but is durable. It has not been able to be said to have a sufficient moisturizing effect and wrinkle improvement, or to be a skin external preparation that can suppress and improve complex signs of aging.

Skin aging is not an event that occurs alone, but a combination of skin changes that occur and progress, so it is not only effective for moisturizing and improving wrinkles, but also for maintaining skin moisture. Improved ability (moisturizing effect after a certain period of time), recovering from rough skin due to improved skin barrier function, reducing fine lines and improving complex signs of aging such as skin firmness and elasticity In addition, there has been a strong demand for a skin cosmetic that is not sticky and has an excellent feel to use.

JP 2006-056902 A JP 2004-238334 A JP-A-8-73312 Japanese Patent No. 4351997 Patent No. 4025600

An object of the present invention is to provide a skin cosmetic with less stickiness after application that can improve dryness of the skin and its associated skin, reduce wrinkles, and improve the firmness and elasticity of the skin.

As a result of intensive studies in view of the above problems, the present inventors have selected from melon placenta extract, hyaluronic acid and its salts, collagen hydrolysates, and ceramides that have been reported to have a moisturizing effect. By combining one or two or more kinds of ingredients that enhance the skin moisturizing function and one or more anti-aging ingredients selected from retinol and its derivatives, royal jelly extract, or urgon root extract As a result, the present inventors have found that the above-described problems can be solved and the present invention has been completed.

1st invention of this application is a skin cosmetic characterized by containing the following component (A)-(C).
(A) Melon placenta extract (B) Hyaluronic acid and salts thereof, collagen hydrolyzate, one or more selected from ceramides (C) Retinol and derivatives thereof, royal jelly extract, urgonum root extract One or more selected

The second invention of the present application is the addition of a melon placenta extract to the skin cosmetic containing the following components (B) and (C), thereby improving the moisturizing function of the skin cosmetic, the effect of improving that skin, and the effect of improving fine lines. And a method for improving the elasticity and elasticity improvement effect of the skin.
(B) One or more kinds selected from hyaluronic acid and salts thereof, collagen hydrolyzate, ceramide (C) Retinol and derivatives thereof, royal jelly extract, or eugonum root extract

ADVANTAGE OF THE INVENTION According to this invention, while improving dryness of the skin and the skin which accompanies it, the skin cosmetics with few stickiness after application | coating which can reduce a fine wrinkle and can improve the firmness and elasticity of skin can be provided.

Hereinafter, the present invention will be described in detail.

The (A) melon placenta extract used in the skin cosmetic of the present invention is an extract extracted from the placenta of Melon (Cucumis melo).

The component (A) used in the present invention is, as it is or after pulverization, water, lower alcohols such as ethanol, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, polyhydric alcohol alkyl ethers such as diethylene glycol ether, and the like. Although it can obtain by extracting with a polar solvent or those liquid mixture, it is not limited to these.

The blending amount of (A) melon placenta extract used in the skin cosmetic of the present invention is preferably 0.001 to 5% by mass, more preferably 0.01 to 1% by mass in the total composition. If the amount is less than 0.001% by mass, the effect of improving wrinkles and suppressing the signs of aging cannot be obtained sufficiently, and if it exceeds 5% by mass, stickiness may occur or the stability of the preparation may be impaired.

One or more selected from (B) hyaluronic acid and salts thereof, collagen hydrolysates, and ceramides used in the skin cosmetics of the present invention generally enhance the skin moisturizing function alone. Although it is known, the moisture of the skin can be kept synergistically by combining with the component (A). The combination and type of these components are not particularly limited as long as they are usually used in cosmetics or pharmaceuticals, and commercially available products can be used. The origin of these components is not particularly limited. For example, hyaluronic acid and salts thereof can be selected from, for example, chicken crown-derived or fermented origin, and, if ceramide is derived from, for example, animal-derived or plant-derived.

The blending amount of (B) hyaluronic acid and salts thereof and collagen hydrolyzate used in the skin cosmetic of the present invention is preferably 0.01 to 1% by mass, more preferably 0.1% in the total composition. It is -0.5 mass%.

Moreover, the compounding quantity of the ceramide used for the skin cosmetics of this invention becomes like this. Preferably it is 0.0001-0.005 mass% in conversion of the solid content. In any case, if the blending amount is less than the lower limit, sufficient moisturizing function and that skin improvement effect cannot be obtained, and if the blending amount exceeds the upper limit, stickiness or deposits such as oliage may occur.

Generally, one or more selected from (C) retinol and derivatives thereof, royal jelly extract, and urgon root extract used in the skin cosmetics of the present invention are effective in removing active oxygen alone. In combination with the component (A), it is possible to synergistically enhance the anti-aging effect of the skin (the effect of improving fine wrinkles, the effect of improving skin elasticity and elasticity).

The amount of retinol and its derivatives used in the skin cosmetic of the present invention is preferably 0.0001 to 0.01% by mass in the total composition. If it is less than 0.0001% by mass, sufficient anti-aging effect (wrinkle improving effect, skin firmness / elasticity improving effect) cannot be obtained, and if it exceeds 0.01% by mass, irritation to the skin may occur.

The blending amount of the royal jelly extract and ougon root extract used in the skin cosmetic of the present invention is preferably 0.001 to 1% by mass, more preferably 0.1 to 0.5% by mass in the total composition. It is. If it is less than 0.001% by mass, sufficient anti-aging effects (wrinkle improvement effect, skin firmness / elasticity improvement effect) cannot be obtained, and if it exceeds 1% by mass, stickiness may occur or the stability of the preparation such as discoloration may be improved. It may be damaged.

The skin cosmetic of the present invention contains the above-described components as essential components, but other components such as an anionic surfactant and an amphoteric interface are included in the composition as long as the object of the present invention is not impaired. Activators, nonionic surfactants, oil agents, polymer compounds, thickeners, powders (dyes, resins, pigments), preservatives, fragrances, moisturizers, physiologically active ingredients, salts, solvents, antioxidants, Components such as a chelating agent, a pearling agent, a neutralizing agent, a pH adjusting agent, an insect repellent, and an enzyme can be appropriately blended.

In addition, a physiologically active ingredient can be appropriately blended in the skin cosmetic of the present invention as long as the object of the present invention is not impaired. A physiologically active substance is a substance that imparts some physiological activity to the skin when applied to the skin, such as anti-aging agents, UV protection agents, tanning agents, antioxidants, moisturizers, blood circulation promoters, antibacterial agents, Examples include bactericides, desiccants, cooling agents, warming agents, vitamins, amino acids, wound healing promoters, irritation relaxation agents, analgesics, cell activators, enzyme components, and the like.

The type of the physiologically active ingredient that can be blended in the skin cosmetic of the present invention is not particularly limited, but it is preferable to use an extract derived from a plant root, stem, leaf, flower, fruit, or seed. Examples of extracts derived from plant roots, stems, leaves, flowers, fruits and seeds include, for example, Ashitaba extract, Avocado extract, Achacha extract, Altea extract, Arnica extract, Aloe extract, Itadori extract, Fennel extract, Ages Extract, barley extract, hypericum extract, oyster extract, cuckoo extract, chamomile extract, carrot extract, licorice extract, raspberry extract, kiwi extract, cucumber extract, kyonin extract, quince seed extract, brown sugar extract, rice bran extract, fermented rice bran extract, sugar maple extract, Sugarcane extract, perilla extract, peony extract, honeysuckle extract, Hypericum perforatum extract, hawthorn extract, elderberry extract, sage extract, soybean extract, Thailand Extract, tea extract, camellia extract, camellia extract, dodami extract, tomato extract, wild rose extract, hamamelis water, rose extract, parietaria extract, loquat extract, grape extract, loofah extract, button extract, hop extract, mugwort extract, peach leaf extract, cornflower extract , Yokuinin extract, lemon extract, rosemary extract, Roman chamomile extract and the like.

The skin cosmetic of the present invention can be produced according to a conventional method. Examples of the skin cosmetic of the present invention include basic cosmetics, makeup cosmetics, body cosmetics and the like. The dosage form can also be arbitrarily selected according to the purpose. That is, liquids, creams, gels, emulsions, sheets, sticks, aerosols and the like can be mentioned. The skin cosmetics of the present invention are not limited to general cosmetics, and include quasi drugs, designated quasi drugs, topical drugs and the like.

EXAMPLES Hereinafter, although an Example and a comparative example illustrate this invention concretely, this invention is not limited at all by these Examples. Prior to the examples, test methods and evaluation methods employed in each example will be described.

<Moisturizing effect test>
(Evaluation method)
For five evaluation panels, the entire face was washed with soap, and then acclimated for 20 minutes in an environment of a temperature of 25 ° C. and a relative humidity of 50%. cm ^{2 was} applied. After application, the sample was acclimated for 60 minutes in an environment at a temperature of 25 ° C. and a relative humidity of 50%, and the keratin water content (conductance value) was measured using a Corneometer (MPA580, manufactured by Courage + Khazaka). The evaluation of the moisturizing effect was carried out based on the following judgment criteria by calculating the moisturizing effect (%) from the following calculation formula to obtain an average value of 5 persons.
Moisturizing effect (%) = (Keratin water content at 1 hour after application / Keratin water content before application) × 100
(Judgment criteria)
◎: Moisturizing effect (%) was 140% or more ○: Moisturizing effect (%) was 120% or more and less than 140% △: Moisturizing effect (%) was 100% or more and less than 120% ×: Moisturizing effect (%) was less than 100%

<Fine wrinkle improvement effect test by drying the eyes>
(Evaluation method)
For three evaluation panels, a test was carried out for 4 weeks, in which an appropriate amount of the skin cosmetic of the present invention was applied to one eyepiece part and pure water was applied to the other eyelet part twice a day. A replica of the wrinkles before and after continuous use was collected with SILFLO (registered trademark) (manufactured by FLEXICO DEVEROPMENTS) from the periphery of the left and right eyes with the eyes lightly closed. The three-dimensional shape of the collected replica was measured using a non-contact 3D measuring device PRIMOS Lite (manufactured by GF Messtechnik). The fine wrinkle improvement effect was evaluated by calculating the fine wrinkle improvement effect (%) from the following formula to obtain the average value of the three persons and based on the following criteria.
Fine wrinkle improvement effect (%) = (average depth of total wrinkles after continuous use in the eyes coated with pure water / average depth of total wrinkles before continuous use in the eyes applied with pure water) × 100− (skin of the present invention Average depth of total wrinkles after continuous use in eyes applied with cosmetics / average depth of total wrinkles before use in eyes applied with skin cosmetics of the present invention) × 100
(Judgment criteria)
◎: Wrinkle improvement effect (%) was 20% or more ○: Wrinkle improvement effect (%) was 10% or more and less than 20% △: Wrinkle improvement effect (%) was 5% or more and less than 10% ×: Wrinkle improvement effect (%) was less than 5%

<That skin improvement test>
(Evaluation method)
About 5 specialist panels, the inner part of the forearm was washed with soap, and then acclimatized for 20 minutes in an environment of a temperature of 25 ° C. and a relative humidity of 50%, and then the keratin moisture transpiration (TEWL) was measured. Thereafter, 0.1 mL / cm ² of the skin cosmetic of the present invention was applied. After application, the sample was acclimated for 60 minutes in an environment at a temperature of 25 ° C. and a relative humidity of 50%, and the keratin moisture transpiration (TEWL) was measured again. The evaluation of that skin improvement effect was carried out based on the following criteria, by calculating the skin improvement effect (%) and calculating the average value of 5 people from the following formula.
That skin improvement effect (%) = {1− (amount of horny water transpiration after 1 hour after application / amount of horny water transpiration before application)} × 100
(Judgment criteria)
◎: That skin improvement effect (%) was 40% or more ○: That skin improvement effect (%) was 20% or more and less than 40% △: That skin improvement effect (%) was 10% or more and 20% X: That skin improvement effect (%) was less than 10%

<Skin elasticity and elasticity improvement test>
(Evaluation method)
For 5 specialist panels, the inner forearm was washed with soap, then acclimated for 20 minutes in an environment of temperature 25 ° C. and relative humidity 50%, and then the skin cosmetic of the present invention was applied to the cheek at 0.1 mL / cm ^{2 was} applied. After application, the skin was acclimated for 60 minutes in an environment of a temperature of 25 ° C. and a relative humidity of 50%, and the viscoelasticity of the skin was measured using a Cutometer (MPA580, manufactured by Courage + Khazaka). The skin elasticity / elasticity improvement effect was evaluated based on the following judgment criteria by calculating the elasticity / elasticity improvement effect (%) from the following formula to obtain an average value of 5 persons.
Elasticity / elasticity improvement effect (%) = (skin elasticity at 60 minutes after application / skin elasticity before application) × 100
(Judgment criteria)
◎: The elasticity / elasticity improvement effect (%) was 107% or more. ○: The elasticity / elasticity improvement effect (%) was 105% or more and less than 107%. △: The elasticity / elasticity improvement effect (%) was 100%. It was less than 105% ×: The elasticity / elasticity improvement effect (%) was less than 100%

<Evaluation test without stickiness>
(Evaluation method)
About 5 professional panels, the skin cosmetics of the present invention were applied to the inner side of the forearm and evaluated for “stickiness” 1 minute after lightly familiarizing with fingers. The test results were judged according to the following evaluation criteria using the number of people who answered that there was stickiness.
(Evaluation criteria)
◎: 0 panelists recognized as sticky ○: 1 panelist recognized as sticky △: 2 to 4 panelists recognized as sticky ×: 4 panelists recognized as sticky Name or 5

<Examples 1-15 and Comparative Examples 1-8>
The skin cosmetics in each formulation of Examples 1 to 15 and Comparative Examples 1 to 8 shown in Table 1 and Table 2 were prepared by a conventional method and evaluated by each test method. The results are also shown in Table 1 and Table 2.

As is clear from Tables 1 and 2, the skin cosmetics of Examples using the components of the present invention had excellent performance. On the other hand, the comparative example lacking any of the essential components is inferior in any of the moisturizing effect, that skin improving effect, the wrinkle improving effect, the skin elasticity / elasticity improving effect, and the non-stickiness. The purpose of could not be achieved.

Hereinafter, other formulation examples of the present invention will be given as Example 16 and Example 17. Regarding the skin cosmetics of these examples, each item was examined for the above-mentioned moisturizing effect, that skin improving effect, wrinkle improving effect, skin firmness / elasticity improving effect, and non-stickiness. The examples also had excellent characteristics and were good.

Example 16
(1) Ethanol 3.0%
(2) Dipropylene glycol 3.0%
(3) Glycerin 10.0%
(4) Sorbitol 1.0%
(5) Carboxyvinyl polymer 0.2%
(6) Potassium hydroxide 0.06%
(7) Xanthan gum 0.2%
(8) POE (60) hydrogenated castor oil 0.3%
(9) EDTA-2Na 0.01%
(10) Water-soluble collagen 0.1%
(11) Hyaluronic acid Na 0.1%
(12) Melon placenta extract 0.2%
(13) Vitamin A oil 0.0001%
(14) Royal jelly extract 0.1%
(15) Aloe extract 0.1%
(16) Cucumber fruit extract 0.1%
(17) Altea extract 0.01%
(18) Sage extract 0.01%
(19) fennel extract 0.01%
(20) Centella extract 0.01%
(21) Grape leaf extract 0.01%
(22) Rosemary leaf extract 0.01%
(23) Tea leaf extract 0.01%
(24) Bilberry fruit extract 0.001%
(25) Knotweed Root Extract 0.001%
(26) Sugarcane extract 0.001%
(27) Lemon fruit extract 0.01%
(28) Orange fruit extract 0.01%
(29) Methyl paraben 0.1%
(30) Phenoxyethanol 0.2%
(31) Purified water residue

(Manufacturing method)
(3) to (6) and (9) are added to (31) and dissolved (solution A). (8), (13), (29), and (30) are dissolved in (1), and then gradually added to the liquid A and dispersed uniformly (liquid B). After (7) is dispersed in (2) and slowly added to the B liquid and mixed, (10) to (12) and (14) to (28) are added and dispersed uniformly to obtain the skin cosmetic. Prepared.

Example 17
(1) Stearic acid 1.0%
(2) Behenyl alcohol 2.0%
(3) Glyceryl monostearate 2.0%
(4) Mineral oil 3.0%
(5) Vaseline 0.1%
(6) Myristic Sanoctyldodecyl 5.0%
(7) Dimethicone 0.05%
(8) Stearoyl glutamate Na 2.0%
(9) Dipropylene glycol 6.0%
(10) Methylparaben 0.2%
(11) EDTA-2Na 0.05%
(12) Carboxyvinyl polymer 0.2%
(13) Melon placenta extract 0.2%
(14) Ceramide (from yuzu fruit, in terms of solid content) 0.0002%
(15) Lotus seed fermentation solution 0.01%
(16) Royal jelly extract 0.2%
(17) Ogon root extract 0.1%
(18) Soybean seed extract 0.05%
(19) Folic acid 0.001%
(20) Chamomile flower extract 0.001%
(21) Cornflower flower extract 0.001%
(22) Arnica flower extract 0.001%
(23) Roman chamomile flower extract 0.001%
(24) Fuyubodaiju Flower Extract 0.001%
(25) Tokashinka Flower Extract 0.001%
(26) Rose water 0.003%
(27) Clam leaf extract 0.025%
(28) Tea leaf extract 0.025%
(29) Grape leaf extract 0.025%
(30) Peach leaf extract 0.025%
(31) Arge extract 0.05%
(32) Hypericum perforatum flower / leaf / stem extract 0.001%
(33) Peonies root extract 0.01%
(34) Hop extract 0.01%
(35) Purified water residue

(Manufacturing method)
Add (8) to (34) to (35) with sequential stirring, warm until homogeneously dissolved, add to (1) to (7) dissolved by warming and uniformly disperse, then cool A skin cosmetic was prepared.

Claims (2)

A skin cosmetic comprising the following components (A) to (C).
(A) Melon placenta extract (B) Hyaluronic acid and salts thereof, collagen hydrolyzate, one or more selected from ceramides (C) Retinol and derivatives thereof, royal jelly extract, urgonum root extract One or more selected By adding melon placenta extract to skin cosmetics containing the following components (B) and (C), the skin cosmetics moisturizing function, that skin improving effect, wrinkle improving effect, and skin firmness and elasticity A method to improve the improvement effect.
(B) One or more kinds selected from hyaluronic acid and salts thereof, collagen hydrolyzate, ceramide (C) Retinol and derivatives thereof, royal jelly extract, or eugonum root extract