JP2011241228A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin preparation for external use preventing development of or improving a wrinkle due to skin dryness, skin roughness, decline of skin firmness and elasticity.SOLUTION: There is provided the skin preparation for external use, that includes: (a) retinol palmitate; (b) hinokitiol and/or a derivative thereof; and (c) epidermal lipid and/or a similar ingredient thereof.

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin effective for preventing and improving the formation of dry skin, rough skin, fineness of skin, fine lines and the like due to a decrease in elasticity.

  Skin dryness, rough skin, fineness caused by reduced skin elasticity and elasticity, etc. are caused by inadequate nutrition due to poor blood circulation of the skin, irregular life, ill-care, and coldness in addition to aging and sun exposure. It occurs due to environmental factors such as dryness. Therefore, development of various medicinal ingredients has been demanded for the purpose of preventing and improving dry skin, rough skin, fine wrinkles and the like.

In recent years, wrinkle improvement technology using retinol, vitamin A acid and its derivatives has been used for the purpose of preventing and improving such dry skin, rough skin, fine lines, etc. Not enough. Therefore, the development of a skin external preparation having further excellent effects is awaited.

Under these circumstances, the development of external preparations for skin containing various ingredients extracted from natural products and the method of physically and temporarily wrinkling with a film-forming agent have been used as improvement methods, but they are still insufficient. It is.

  Accordingly, an object of the present invention is to provide an external preparation for skin which can prevent or improve the occurrence of dry skin, rough skin, skin firmness and fine lines associated with a decrease in elasticity.

In order to achieve the above-mentioned object, the present inventors obtain a substance that exhibits an improvement effect such as dry skin, rough skin, firmness of the skin, fine wrinkles associated with a decrease in elasticity, among substances having excellent safety. Therefore, as a result of intensive research, these problems were solved by containing vitamin A, hinokitiol, and epidermal lipid, and the present invention was completed.

  That is, the present invention contains at least one substance selected from (A) retinol palmitate, (B) hinokitiol, and (C) sterol, sphingolipid and glyceride, which are epidermal lipid components. An agent is provided. Hereinafter, the configuration of the present invention will be described in detail.

The retinol palmitate used in the present invention is a vitamin A derivative. Vitamin A is a compound that is usually used as an effective component for the prevention and treatment of cutaneous keratosis and the like, as well as the prevention and recovery of skin aging, especially wrinkles. Among these, various isomers such as retinol, retinal, retinoic acid, and derivatives thereof (retinol palmitate, retinol acetate, etc.) are particularly preferable.

The amount of retinol palmitate added to the external preparation for skin of the present invention is not limited, but is preferably 0.001% to 5.0% by weight, more preferably 0.01% to 1.0% by weight. .

The hinokitiol used in the present invention is a tropolone compound also called β-tsuyapricin, which is a component naturally extracted from essential oils of Aomori Hiba and Taiwan Hinoki. Hinokitiol is a compound that is widely used as a bactericidal agent, cell activator, etc., in the fields of pharmaceuticals, cosmetics, etc., regardless of whether it is natural or synthetic. Hinokitiol or its derivatives are particularly preferred.

The amount of hinokitiol added to the external preparation for skin of the present invention is not limited, but is preferably 0.0001% by weight to 2.0% by weight, and more preferably 0.0005% by weight to 0.5% by weight.

The epidermal lipid used in the present invention is a general term for lipids existing in the skin, and is a component that is generally widely used as a base or an emollient in fields such as pharmaceuticals and cosmetics. Among these, sterols and / or derivatives thereof, sphingolipids and / or derivatives thereof, phospholipids and / or derivatives thereof, glycerides and / or derivatives thereof are particularly preferable.

In addition, examples of sterols include cholesterol, dehydrocholesterol, ergosterol, sitosterol, campesterol, stigmasterol, brassicasterol, and fucosterol, and derivatives include esters thereof.

Examples of sphingolipids include sphingosine, sphingomyelin, glycosphingolipid, cerebroside, phytosphingosine, ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6 and their derivatives.

Examples of phospholipids include phosphatidylcholine, lysophosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and their derivatives.

Examples of glycerides include oils and fats derived from animals and plants such as monoglycerides, diglycerides and triglycerides, and derivatives thereof.

The blending amount of the epidermal lipid and / or a similar component in the external preparation for skin of the present invention is not limited, but is preferably 0.01% to 20.0% by weight, more preferably 0.1% to 10.0%. Weight percent is more preferred.

In addition to the essential components described above, the external preparation for skin of the present invention, if necessary, within the range not impairing the effects of the present invention, various components commonly used in cosmetics, quasi drugs, pharmaceuticals, etc., aqueous components, Moisturizers, thickeners, UV absorbers, UV scattering agents, preservatives, antioxidants, fragrances, colorants, drugs, herbal medicines, and the like are blended. The dosage form of the external preparation for skin of the present invention is arbitrary, for example, a solubilizing system such as lotion, an emulsifying system such as an emulsion or cream, or an ointment, a powder dispersion system, a water-oil two-layer system, a water-oil -An agent system such as a powder three-layer system may be used.

Examples of the present invention will be described below, but these examples do not limit the present invention. Each formulation was prepared by adding an oil phase heated to the same temperature to an aqueous phase heated to 80 ° C., stirring and emulsifying, and cooling to room temperature.

The following composition was manufactured and the skin improvement effect was examined. It is known that such skin is caused by dryness of the skin and progresses to fine lines and wrinkles when left untreated.

＜あれ肌改善試験方法＞ 人の前腕部（３ｃｍ×３ｃｍ）に１０％ラウリル硫酸ナトリウム水溶液を、６時間閉鎖発布し、あれ肌モデルを作成する。実施例１、比較例１〜７をそれぞれ、０．０５ｇずつ１日３回塗布し、４日後、８日後のあれ肌部を肉眼判定および角質水分量の測定により改善度の評価を行った。角質水分量の測定は、皮表角質水分量測定装置：SKICON−２００（アイ・ビー・エス株式会社製）で行った。その結果を表２、表３に示す。

<That Skin Improvement Test Method> A 10% sodium lauryl sulfate aqueous solution is closed and promulgated on a human forearm (3 cm × 3 cm) for 6 hours to create a skin model. Example 1 and Comparative Examples 1 to 7 were each applied 0.05 g three times a day, and the degree of improvement was evaluated by visual inspection and measurement of the amount of keratinous moisture after 4 and 8 days. The stratum corneum moisture content was measured with a skin surface stratum corneum moisture measuring device: SKICON-200 (manufactured by IBS Co., Ltd.). The results are shown in Tables 2 and 3.

As is clear from the results of Tables 2 and 3, it was found that the present invention of Example 1 had an excellent skin improvement effect as compared with those of Comparative Examples 1-7.

Next, the formulation of the composition of Table 4 (Example 2, Comparative Examples 8 to 10) was adjusted by a conventional method, and an actual use test for 2 months was performed. As panelists, 20 women in their late 30's to 50's who had marked symptoms such as dry skin and fine lines were used. These compositions are used twice a day in the morning and evening for 2 months, and the skin condition is “improved”, “slightly improved”, and “no change” before the start of use test and after the end of use test. Evaluated. The results of the test are shown in Table 5 as the number of panelists that obtained each evaluation.

表５に示されるように、皮膚の乾燥、ハリ・弾力性の低下、小じわ等の改善状況については、実施例２の本発明は比較例８〜１０のものに比べて格段に優れた小じわ等の改善効果を有していることが認められた。また、実施例使用群において、皮膚刺激性反応や皮膚感作性反応を示したパネラーも存在しなかった。

As shown in Table 5, with regard to the improvement status of skin dryness, reduction of elasticity / elasticity, fine wrinkles, etc., the present invention of Example 2 is significantly superior to those of Comparative Examples 8-10. It was confirmed to have an improvement effect. In addition, there was no panel exhibiting a skin irritation reaction or a skin sensitization reaction in the example use group.

Next, the formulation example of the skin external preparation which mix | blended vitamin A of this invention, hinokitiol, and epidermal lipid is shown.

Lotion Toner Retinol Palmitate 0.01 (wt%)
Hinokitiol 0.001
Hydrogenated soybean phospholipid 0.1
Hydroxyethyl cellulose 0.1
1,3-butylene glycol 3.0
Paraben 0.2
Polyoxyethylene hydrogenated castor oil 0.3
Alcohol 10.0
Plant extract 0.5
Perfume 0.03
Purified water balance

Latex Retinol acetate 0.1 (wt%)
Hinokitiol 0.01
Phosphatidylethanolamine 0.5
Ceramide 3 0.01
Carboxyvinyl polymer 0.3
1,3-butylene glycol 5.0
Paraben 0.2
Polyoxyethylene hydrogenated castor oil 0.1
Polyglycerin fatty acid ester 1.0
Polyoxyethylene sorbitan fatty acid ester 0.3
Liquid paraffin 3.0
Potassium hydroxide 0.07
Plant extract 0.5
Perfume 0.03
Purified water balance

Cream Retinol 0.1 (wt%)
Hinokitiol 0.1
Cholesterol 1.0
Rhizophosphatidylcholine 0.1
Olive oil 2.0
Glycerin 15.0
Paraben 0.2
Carboxyvinyl polymer 0.3
Polyoxyethylene hydrogenated castor oil 0.1
Monoglycerin fatty acid ester 5.0
Propylene glycol fatty acid ester 5.0
Polyethylene glycol fatty acid ester 0.5
Squalane 10.0
Behenyl alcohol 3.0
Stearic acid 1.0
Plant extract 0.5
Perfume 0.03
Purified water balance

Cosmetic liquid Retinol acetate 0.1 (wt%)
Hinokitiol 0.001
Safflower oil 1.0
Ceramide 3 0.01
Hydroxyethyl cellulose 0.6
Dipropylene glycol 10.0
Paraben 0.2
Polyoxyethylene hydrogenated castor oil 0.1
Polyglycerin fatty acid ester 2.0
Polyoxyethylene sorbitan fatty acid ester 0.5
Squalane 5.0
Stearic acid 1.0
Plant extract 0.5
Perfume 0.03
Purified water balance

  As described above in detail, the external preparation for skin of the present invention is remarkably superior to other compositions in preventing and improving dry skin, rough skin, skin firmness and fine lines caused by reduced elasticity. It shows the effect.

The change with time of the amount of keratin moisture of that skin shown by Table 3 is shown.

Claims (2)

A skin external preparation characterized by containing at least one or more substances selected from (A) retinol palmitate, (B) hinokitiol, and (C) sterol, sphingolipid and glyceride which are epidermal lipid components. A skin external preparation characterized by containing three types of phytosterol, ceramide 2 and medofoam oil as the component (C).

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