JP2001233754A - Emulsion type skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation which has excellent storage stability and functional characteristics. SOLUTION: This emulsion type skin care preparation includes ceramide, phospholipid, a cholesterol complex, a liquid oil and hexyleneglycol.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an emulsified external preparation for skin which has excellent storage stability and organoleptic properties.

[0002]

2. Description of the Related Art It has recently been known that ceramide, which is a kind of lipid, has an important physiological role although its quantity is smaller than that of glycerolipid which occupies most of the body. Ceramide exists in places where the biodistribution in mammals including humans is also physiologically important, and is accumulated especially in the brain, liver, skin and the like.

[0003] In the skin, ceramide is accumulated particularly in the stratum corneum of the epidermis. It is synthesized and secreted by epidermal cells and is a major component of intercellular lipids forming a unique lamellar structure between cells (Lukas Landmann: Anat Embryol, 178, 1-3, 1988). . The stratum corneum has a series of physiological roles including the moisturizing ability of the skin and physical protection of the living body, so-called barrier functions, but intercellular lipids are the substance of this barrier function and are the most important in life support (Genji Imokawa: Journal of Koshokai, Vol. 15 (4), pp. 250-253, 1991)
Year). In this sense, it can be said that skin ceramide is one of the important substances responsible for the barrier function. Therefore, improvement of the skin barrier function is expected by uniformly forming a ceramide-containing coating on the skin.

[0004] However, ceramide is generally difficult to dissolve in oils and water used for external preparations for the skin, and it has been very difficult to formulate ceramide. Therefore, a complex (hereinafter, ceramide, phospholipid,
A technology for making sterol composites was created, and formulations were developed using these. However, even in such cases, blending of oil was difficult, and ceramide and liquid oil were blended to maintain their functions. However, it has been difficult to obtain a skin external preparation having excellent sensory characteristics and storage stability.

[0005]

In view of such circumstances, as a result of various studies by the present inventors, they have found that ceramide, phospholipid, and sterol composites have a high emulsifying power in the presence of hexylene glycol. It has been found that the emulsified composition is functionally superior and has excellent storage stability, and has led to the completion of the present invention. An external skin preparation is provided.

[0006]

The first object of the present invention to achieve the above object is to provide an emulsified type external skin containing ceramide, phospholipid, sterol compound, liquid oil and hexylene glycol. Agent.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the present invention will be described in detail.

The ceramide of the present invention is a known substance and includes ceramides of various structures generally referred to as type 1 to type 6, such as N-stearoylphytosphingosine (manufactured by Nikko Chemicals Co., Ltd.) and ceramide HO3.
(Manufactured by Croda Japan) and Ceramide 2 (TTC001 manufactured by Takasago International Corporation). The amount of ceramide in the composite of the present invention is preferably 5 to 50% by mass, and particularly preferably 10 to 40% by mass. When the content is more than 50% by mass or less than 5% by mass, the effect of the present invention may not be sufficiently exhibited.

[0009] The phospholipid used in the present invention is a known substance, and sphingomyelin, hydrogenated lecithin derived from soybean, egg yolk and the like can be used.
-21 (manufactured by Nikko Chemicals), Phosphophorpon 90
H (manufactured by Nippon Seika), YOK95 (manufactured by YMC) and the like can be used. The amount of the phospholipid in the complex is 30.
To 80% by mass, particularly preferably 35% by mass.
７０70% by mass. More than 80% by mass, and 3
When the amount is less than 0% by mass, the effect of the present invention may not be sufficiently exhibited.

[0010] The sterol used in the present invention is a known substance and includes cholesterol, phytosterol and the like. This sterol does not contain sterol esters.

The ceramide, phospholipid, and sterol complex of the present invention is prepared by dissolving these lipid components in an organic solvent once and removing the solvent under reduced pressure. , Hydrocarbons such as hexane, heptane and cyclohexane, methylene chloride, chloroform, benzene, toluene, methanol, ethanol,
Methyl acetate, ethyl acetate and the like can be used. The amount of the organic solvent used is not particularly limited. Ceramide, phospholipids,
As the sterol composite, for example, ceramide presome manufactured by Nippon Seika Co., Ltd. or the like can be used, but it is not limited thereto. The amount of the ceramide, phospholipid, and sterol complex to be added to the emulsified skin external preparation of the present invention is preferably 0.01 to 10% by mass, and particularly preferably 0.1 to 3% by mass, based on the total amount of the composition. Mass. When the content is more than 10% by mass or less than 0.01% by mass, the effect of the present invention may not be sufficiently exhibited.

The liquid oil used in the present invention may be a liquid oil at room temperature. For example, silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane, methylcetylpolysiloxane, and cyclic silicone, liquid paraffin, olefin oligomers, hydrocarbons such as squalane, dioctylhexanol, olive squalane, rice squalane, rice germ oil, jojoba oil , Apricot kernel oil, castor oil, safflower oil, olive oil, macadamia nut oil, sunflower oil,
Rapeseed oil, vegetable oils such as cottonseed oil, ester oils such as octyldodecyl myristate, isostearyl isostearate, isopropyl myristate, and isostearyl lactate;
Higher fatty acids such as isostearic acid and oleic acid, triglycerides such as glyceryl tricapryl / caprate, glyceryl 2-ethylhexanoate, and triglyceryl isostearate, and ether oils such as dioctyl ether can be used. The amount of these liquid oils to be incorporated into the emulsified skin external preparation of the present invention is 0.1% based on the total amount of the composition.
It is preferably from 0.5 to 50% by mass, particularly preferably from 0.1 to 50% by mass.
40% by mass.

The amount of hexylene glycol incorporated into the emulsified external preparation for skin of the present invention is 0.1% based on the total amount of the composition.
1-50 mass% is preferred. When the amount exceeds the upper limit of the amount, the storage stability is reduced, and an effect corresponding to the amount exceeding the amount cannot be expected.If the amount is less than the lower limit, the object of the present invention may not be achieved. .

The form of use of the emulsified external skin preparation of the present invention includes, for example, ointments, creams, lotions, emulsions, packs, gels and the like, and can be applied to pharmaceuticals, quasi-drugs, cosmetics and the like.

[0015] In addition to the above, the emulsified skin external preparation of the present invention may further comprise a solid or semi-solid such as tar pigments, coloring pigments such as iron oxide, preservatives such as paraben and phenoxyethanol, paraffin, petrolatum, olefinoligomer, and the like. Hydrocarbons, beeswax, beeswax, wax such as carnauba wax, solid or semi-solid ester oils such as cetyl palmitate, lower alcohols such as ethanol, cetanol, behenyl alcohol, stearyl alcohol, and long-chain branched aliphatic alcohols Higher alcohols, branched fatty acid cholesterol esters, sterol derivatives such as macadamia nut fatty acid phytosteryl esters, processing oils such as hardened oils, higher grades such as stearic acid, palmitic acid, myristic acid, iso long chain fatty acids, and anteiso long chain fatty acids Fatty acids, limonene Terpenes such as hydrogenated bisabolol, triiso-type long chain fatty acid glyceryl, solid or semi-solid triglycerides such as tripalmitin glyceryl, sodium cetyl sulfate, N- stearoyl -L
-Anionic surfactants such as glutamate, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, polyglycerin fatty acid ester, Nonionic surfactants such as modified silicones and sucrose esters, cationic surfactants such as tetraalkylammonium salts, amphoteric surfactants such as betaine type, sulfobetaine type and sulfoamino acid type, and natural surfactants such as cerebroside , Pigments such as titanium oxide and zinc oxide, antioxidants such as dibutylhydroxytoluene, inorganic salts such as sodium chloride, magnesium chloride, sodium sulfate and potassium nitrate, sodium citrate, potassium acetate,
Organic acid salts such as sodium succinate, sodium aspartate and sodium lactate, salts such as ethanolamine hydrochloride, ammonium nitrate and arginine hydrochloride, chelating agents such as edetic acid, xanthan gum, carboxyvinyl polymer, carrageenan, pectin, alkyl-modified carboxyvinyl polymer , Alkaline gnestreas B16 polymer, thickeners such as agar, neutralizing agents such as potassium hydroxide, diisopropanolamine and triethanolamine, biopolymers such as hyaluronic acid and collagen, lactic acid bacteria, yeast, and mushrooms Objects, chamomile, pine, oak,
Spinach, aloe, peach, carrot, horsetail, orange, mulberry, peach leaf, sage, loquat leaf, cucumber,
Plant extracts such as vegetation, hibiscus, turmeric, rosemary, pecan nuts, seaweed, licorice, fire spikes, camellia seeds, tea seeds, placental extracts, ultraviolet absorbers such as hydroxymethoxybenzophenone sulfonate, dipropylene glycol , 1,3-butylene glycol, glycerin, propylene glycol, sorbitol, malbitol, diglycerin, polyhydric alcohols such as raffinose, and the like, but are not limited thereto.

[0016]

The present invention will be described below in more detail with reference to examples, comparative examples, and applied examples. The unit of the blending amount in Examples, Comparative Examples and Formulation Examples is% by mass, and the evaluation method is as follows.

Sensory test Twenty adult women applied the samples of Examples and Comparative Examples to the face and evaluated the number of persons who did not feel sticky or slimy. Storage stability test 100 ml of each sample of Examples and Comparative Examples was placed in a glass bottle and allowed to stand at room temperature for 2 days. A sample in which no precipitation, creaming, oil film, etc. was observed was evaluated as ○, and an observed one was evaluated as ×.

Examples 1 to 11 and Comparative Examples 1 to 3 (skin cream) After preparation of the emulsified skin external preparations of Examples 1 to 11 shown in Table 1 and the compositions of Comparative Examples 1 and 2 by a conventional method. Using this as a sample, a sensory test and a storage stability test were performed. Here, ceramide presome (N-stearoyl phytosphingosine: phospholipid: cholesterol = 4: 4: manufactured by Nippon Seika Co., Ltd.) as a ceramide, phospholipid, and sterol complex.
2, mass ratio) or ceramide presome K (optically active ceramide 2: phospholipid: cholesterol = 4: 4: 2, mass ratio), which are hereinafter abbreviated as presome and presome K, respectively. The test results are shown in Tables 1 and 2.

[0019]

[Table 1]

[0020]

[Table 2]

The emulsified external preparation for skin of the present invention was found to have excellent organoleptic properties and storage stability as compared with the composition of Comparative Example.

The formulation examples of the emulsified external skin preparation of the present invention are shown below.

Formulation Examples 1 to 3 Ceramide, phospholipid, cholesterol complex, liquid oil, and hexylene glycol were blended in the compositions shown in Table 3 according to the following preparation methods to prepare skin creams.

[0024]

[Table 3]

The components (A) and (B) were each heated to 80 ° C.
After heating and dissolving in water, mix and cool while stirring
After cooling down, a skin cream was prepared.

Application Examples 4 to 6 Ceramide, phospholipid, cholesterol complex, liquid oil, and hexylene glycol were blended according to the following preparation method with the compositions shown in Table 4 to prepare emulsions.

[0027]

[Table 4]

The components were mixed and dissolved at 80 ° C.
After cooling to 0 ° C., an emulsion was prepared.

Application Examples 7 to 9 (Essence) Serum, a phospholipid, a cholesterol complex, a liquid oil, and hexylene glycol were blended with the compositions shown in Table 5 according to the following preparation methods to prepare a serum.

[0030]

[Table 5]

The components (A) and (B) were each heated to 80 ° C.
After heating and dissolving in water, mix and cool while stirring
After cooling, a serum was prepared.

Formulation Examples 10 to 12 A ceramide, a phospholipid, a cholesterol complex, a liquid oil, and hexylene glycol were blended in the compositions shown in Table 6 according to the following preparation method to prepare a sunscreen.

[0033]

[Table 6]

The components (A) and (B) were each heated to 80 ° C.
After heating and dissolving in water, mix and cool while stirring
After cooling, a sunscreen was prepared.

[0035]

As described above, it is apparent that the present invention provides an emulsified skin external preparation having excellent storage stability and organoleptic properties.

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Claims (1)

[Claims] 1. An emulsified external skin preparation comprising ceramide, phospholipid, sterol complex, liquid oil and hexylene glycol.