JP2003238383A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation for sites around the eyes, consisting of a composition containing coix seed and associated with new applications, and capable of ameliorating dark areas, small wrinkles and swelling. <P>SOLUTION: The skin care preparation comprises coix seed and/or its extract, a cell proliferation promoter and a blood circulation promoter. As the cell proliferation promoter, a plant such as aloe, Taraxacum officinale, Cnidium officinale, Mulberry bark, carrot or hop, or its extract is used. As the blood circulation promoter, vitamin E and/or its derivative, a plant such as almond, peanut, perilla or pumpkin, or its extract is used. This skin care preparation is useful for ameliorating dark areas, small wrinkles and swelling around the eyes. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin, and more particularly to an external preparation for or around the eyes which can improve bears, fine lines and swelling.

[0002]

2. Description of the Prior Art Yokuinin has been known as a herbal medicine having a moisturizing effect and an anti-inflammatory effect, and its application example is a special drug containing saccharides and amino acids obtained by hydrolyzing Yokuinin as a main component. A skin cosmetic containing an extract and having a moisturizing action, an emulsion stability, an antioxidant action and the like has been disclosed (Japanese Patent Publication No. 3-36884). Further, Japanese Patent Application Laid-Open No. 11-228436 describes Yokuinin and Yokuinin extract as the essence of a crude drug having a tsu liquid improving effect.

[0003]

However, in these prior arts, Yokuinin and Yokuinin extract are used alone, and there is no disclosure of a finding of a compounded composition with other components. 228436
In the gazette, actually, the efficacy of Yokuinin extract alone is only examined (see especially "Example" of the gazette). Further, what has been studied in these conventional techniques is usefulness as general cosmetics and foods, and no study as an external preparation suitable for the eyes or exclusively for the eyes has been made.

The present invention has been made in view of the above problems of the prior art, and an object of the present invention is to provide a new use composition containing yochinin, which includes bear, fine wrinkles and swelling. An object is to provide a skin external preparation for or around the eyes that can improve the above.

[0005]

Means for Solving the Problems As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that when Yokuinin is blended with predetermined components, bears, fine wrinkles, etc., which occur especially around the eyes, are improved. The present invention has been completed and the present invention has been completed.

[0006] That is, the external preparation for skin for the eyes of the present invention comprises Yokuinin and / or its extract, a cell growth promoter, and
It is characterized by being mixed with a blood circulation promoter.

The preferred form of the external preparation for skin of the present invention is
The cell growth promoter is at least one plant selected from the group consisting of aloe, dandelion, senkyu, sokuhaku, carrot and hop, and / or an extract from these plants or a combination of plants, It is characterized in that the accelerator is vitamin E and / or a derivative thereof. In this case, as the blood circulation promoter, at least one plant selected from the group consisting of almond, peanut, perilla and pumpkin, and / or an extract from these plants or a combination of plants is also applicable.

Further, another preferred form of the external preparation for skin of the present invention is characterized in that it is further blended with pentanediol, and it is desirable not to contain a preservative. Still another preferred embodiment of the external preparation for skin of the present invention is characterized in that it is used for the eyes.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The external preparation for skin for eyes according to the present invention will be described in detail below. In the present specification,
Unless otherwise specified, "%" means mass percentage. As described above, the eye external preparation for skin of the present invention contains yochinin or an extract thereof and a mixture of both, a cell growth promoter and a blood circulation promoter.

Here, as Yokuinin and its extract, conventionally known ones can be used, and those commercially available can be used. In this regard, Japanese Patent Publication No. 3-336
It is not necessary to use a special Yokuinin extract as described in Japanese Patent No. 84. As an extract of Yokuinin, Yokuinin extract extracted from the seeds of Coix seeds is well known and commercially available, but these are said to have a moisturizing effect and an anti-inflammatory effect. In the external preparation for skin of the present invention, Yokuinin or Yokuinin extract mainly has a function of promoting the water metabolism of the eyes and realizing a non-swelling state.

The cell growth promoter is not particularly limited as long as it can promote the growth of cells, especially the skin cells around the eyes, mainly by exerting a moisturizing effect and a barrier function, and includes aloe, dandelion, senkyu, Examples thereof include plants such as souah, carrots and hops, and extracts of these plants, and aloe and aloe extract are particularly preferably used. Further, in the external preparation for skin of the present invention, such plants and extracts thereof can be used alone or in any combination. In the external preparation for skin of the present invention, the cell growth promoter is
It mainly prevents the skin around the eyes from drying and suppresses the generation of fine wrinkles, and also has the function of improving and removing the fine lines that have occurred.

[0012] Usually, the above-mentioned plant is used as the plant itself or a processed product obtained by processing the plant by drying, shredding and crushing. On the other hand, such a plant extract is an extract obtained by extracting the plant or a processed product of the plant with a solvent, a fraction obtained by collecting a liquid obtained by squeezing or steam distillation, and such an extract. It is used as a purified product obtained by liquid-liquid extraction or column chromatography of the fraction or fraction. In addition, the description about such a plant and its extract also applies to the above-mentioned Yokuinin and Yokuinin extract.

A so-called extract is typically used as the extract as described above. Such an extract is obtained by extracting the plant with a polar solvent or dissolving it by acid hydrolysis, enzymatic decomposition or hot water extraction. It can be obtained by, for example, filtering or drying the solution and extracting with a polar solvent, but in the present invention, a method of extracting with a polar solvent is preferable. The plant used for extraction can be dried and / or pulverized, and can be homogenized in an extraction solvent,
It may be crushed by ultrasonic waves. Water or a polar organic solvent can be used as the extraction solvent. Typical examples of the polar organic solvent include lower alcohols such as methanol, ethanol, propanol and isopropanol, and 1,3-
Examples include polyhydric alcohols such as butylene glycol, propylene glycol, dipropylene glycol and glycerin, ethers such as ethyl ether and propyl ether, esters such as ethyl acetate and butyl acetate, and ketones such as acetone and ethyl methyl ketone. It is also possible to use a solvent in which these are arbitrarily combined.

The blood circulation promoter is not particularly limited as long as it can promote blood circulation, but typically,
Mention may be made of vitamin E or its derivatives, and mixtures of both. Further, a plant containing a large amount of vitamin E and an extract thereof are also suitable, and specifically, almond,
Peanuts, plants such as perilla or pumpkin, and extracts of these plants can be exemplified, and in the present invention, these plants and plant extracts can be used in any combination. The most preferable of these are almonds and almond extracts. The meanings of plants and plant extracts are as described above, and various plant extracts can be preferably used in the skin external preparation of the present invention.
In the external preparation for skin of the present invention, the blood circulation promoter mainly has a function of suppressing the generation of bears around the eyes and of improving and removing the generated bears.

In the external preparation for skin of the present invention, the compounding ratio of the above-mentioned three essential components is not particularly limited, and depends on the degree of intended improvement effect, the physical constitution of the user, the specific components used, and the like. Can be changed as appropriate,
Typically, Yokuinin and / or its extract is added to 0.0
001-10%, cell growth promoter 0.0001-10
%, And the blood circulation promoter is preferably blended at a ratio of 0.0001 to 10%. Yokuinin and / or its extract,
In addition, if the content of the cell growth promoter is less than 0.0001%, the intended effect may not be exhibited. If it exceeds 10%, the plant to be compounded will be denatured in the sunlight or high temperature environment, and the effect will be reduced. Or, an unpleasant odor due to the taste as a cosmetic may occur. Also, if the content of the blood circulation promoter is less than 0.0001%, the intended effect may not be obtained, and if it exceeds 10%, it may cause skin irritation from the viewpoint of use on thin skin areas. There is.

The external preparation for skin of the present invention contains the above-mentioned three components as essential components, but other optional components can be added depending on the product form such as lotion, emulsion and cream and other needs. . For example, a general preservative can be appropriately added to the skin external preparation of the present invention. In this case, specific examples of the preservative include isopropylmethylphenol, paraoxybenzoic acid ester and phenols such as 2-phenoxyethanol, and benzoic acid. , Acids such as salicylic acid, dehydroacetic acid and sorbic acid and salts thereof, quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride and alkyltrimethylammonium chloride, alkylaminoethylglycine hydrochloride, stearyl hydroxyethyl betaine and sodium, etc. And amphoteric surfactants, as well as photosensitizers.

In addition, in the external preparation for skin of the present invention, diols having 4 to 7 carbon atoms are added to enable further long-term storage while suppressing further improvement of skin mildness and reduction of desired effects. Can be If such diols are used, it is not necessary to use various preservatives. As such diols, 1,2-pentanediol is preferable. 1,
2-Pentanediol is preferably contained in a proportion of 0.5 to 20% with respect to the total weight of the external preparation for skin.

Examples of product forms to which the external preparation for skin of the present invention can be applied include face wash, lotions, emulsions, creams and packs. In addition, these products may contain moisturizers, amino acids, vitamins, hydrocarbons, higher fatty acids, esters, silicones, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, as necessary. Surfactant, water-soluble polymer,
A pH adjuster, water and the like can be added as appropriate. These components may be added alone, or two or more kinds may be mixed and added.

Examples of the moisturizers include polyethylene glycol, propylene glycol, glycerin,
1,3-butylene glycol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, collagen, sodium lactate, dl-pyrrolidone carboxylate,
Examples include brown sugar extract and chitosan derivative. Examples of the amino acid include neutral amino acids such as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tryptophan, cystine, methionine, proline, hydroxyproline, glutamine and asparagine, and aspartic acid and glutamic acid. Examples thereof include acidic amino acids and basic amino acids such as arginine, histidine, lysine and hydroxylysine. Furthermore, as the above-mentioned vitamins, vitamins A and B
1, B2, B6, C and its derivatives, vitamin E and its derivatives, pantothenic acid and its derivatives, and biotin.

Furthermore, examples of the above-mentioned hydrocarbon include liquid paraffin, paraffin, squalane, petrolatum and the like. Examples of the higher fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid ( EPA) and docosahexaenoic acid (DHA).

Further, as the above-mentioned esters, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, Cetyl lactate, myristyl lactate, lanolin acetate,
Isocetyl stearate, isocetyl isostearate, cholesteryl 2-hydroxystearate, di-2
-Ethylene glycol ethylhexylate, dipentaerythritol fatty acid ester, monoisostearic acid N-
Alkyl glycol, neopentyl glycol dicaprate, diisostearyl malate, glycerin di-2-heptylundecanoate, glyceryl tri-2-ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl Palmitate, glycerin trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, adipic acid 2-
Hexyldecyl, diisopropyl sebacate, 2-ethylhexyl succinate, triethyl citrate and the like can be mentioned.

Furthermore, examples of the silicone include chain polysiloxanes such as dimethylpolysiloxane and methylphenylpolysiloxane, cyclic polysiloxanes such as decamethylcyclopentasiloxane and dodecamethylcyclohexasiloxane, and three-dimensional network structures. The silicon resin etc. which are formed are mentioned.

Examples of the anionic surfactant include acylamino acid salts such as acylglutamates, fatty acid soaps such as sodium laurate and sodium palmitate, and higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate. salt,
POE-Triethanolamine lauryl sulfate and POE
-Alkyl ether sulfate ester salts such as sodium lauryl sulfate, N-acyl sarcosinate salts such as sodium lauroyl sarcosine, and the like.

Further, examples of the above-mentioned cationic surfactant include alkyl trimethyl ammonium salts such as stearyl trimethyl ammonium chloride and lauryl trimethyl ammonium chloride, distearyl dimethyl ammonium chloride dialkyl dimethyl ammonium salt, and poly (N, N'-) chloride. Dimethyl-3,5-methylenepiperidinium) and alkylpyridinium salts such as cetylpyridinium chloride, alkyl quaternary ammonium salts, POE-alkylamines, alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, and benzalkonium chloride. Etc.

Furthermore, as the above-mentioned amphoteric surfactant,
For example, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, and 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy-2-sodium salt and the like. Imidazoline-based amphoteric surfactants and betaine-based amphoteric surfactants such as 2-heptadecyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amidobetaine and sulfobetaine Can be mentioned.

Examples of the nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate and sorbitan trioleate. Ate, sorbitan fatty acid esters such as diglycerol sorbitan penta-2-ethylhexylate and diglycerol sorbitan tetra-2-ethylhexylate, glyceryl monostearate, α, α′-glyceryl pyroglutamate oleate and glyceryl monostearate malate Polyglycerin fatty acid such as glycerin, propylene glycol fatty acid ester such as propylene glycol monostearate, hydrogenated castor oil derivative, glycerin alkyl ether POE- sorbitan monostearate, POE- sorbitan mono Oe rate and PO
POE-sorbitan fatty acid esters such as E-sorbitan tetraoleate, POE-sorbit monolaurate, POE-sorbit monooleate, POE-sorbit pentaoleate, and POE-sorbit fatty acid esters such as POE-sorbit monostearate ,
POE-glycerin monostearate, POE-glycerin monoisostearate and POE-glycerin triisostearate, and other POE-glycerin fatty acid esters, POE-monooleate, POE-distearate, POE-monodioleate, ethylene glycol distearate and the like. POE-fatty acid esters, as well as POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearate diester And P
OE- hydrogenated castor oil POE- castor oil hydrogenated castor oil derivatives such as maleic acid.

Examples of the water-soluble polymer include gum arabic, pectin, agar, starch (rice, corn, wheat), dextran, succinoglucan, pullulan, casein, albumin, gelatin, methylcellulose, nitrocellulose, Cellulosic polymers such as hydroxypropyl cellulose and sodium carboxymethyl cellulose (CMC), alginic acid polymers such as sodium alginate and propylene glycol alginate, polyvinyl alcohol,
Vinyl-based polymers such as polyvinylpyrrolidone and carboxyvinyl polymer (Carbopol), polyoxyethylene-based polymers such as polyethylene glycol 20000, 400,000 and 600,000, polyoxyethylene-polyoxypropylene copolymer copolymer-based polymers, polyacryl Examples thereof include acrylic polymers such as sodium acid salt, and cationic polymers. Furthermore, examples of the pH adjuster include lactic acid-sodium lactate, citric acid-
Examples include buffering agents such as sodium citrate and sodium dihydrogen phosphate-phosphate.

The external preparation for skin of the present invention is suitable for application to the eye area. In this case, the "eye area" cannot be unequivocally defined due to individual differences, but typically, A point 15 mm or less in the horizontal direction (point A), a point 20 mm or less in the vertical downward direction from this point A (point B), a point 20 mm or less in the horizontal direction from the outer corner of the eye (point C), a downward direction vertically from this point C In addition, the face area is defined by four points A to D, which are points (D points) apart from each other by 30 mm or less. However, it does not mean that the external preparation for skin of the present invention cannot be applied to a region other than the eye area, and it is preferable that the eye area is included in the applied area.

[0029]

EXAMPLES The present invention will be described in more detail with reference to some Examples and Comparative Examples, but the present invention is not limited to these Examples.

(Examples 1 to 6 and Comparative Example 1) The following and Table 1
The creams of the respective examples were prepared according to a conventional method according to the composition shown in (1). The following tests were performed on the obtained cream. The obtained results are shown in Table 2 (bear improving effect) and Table 3.
(The effect of improving fine wrinkles) and Table 4 (improvement of texture) are shown.

[Composition of Cream] (Aqueous Phase Component) Glycerin 5.0% 1,3-butylene glycol 6.0% Xanthan gum 0.3% Yokuinin extract 0.1% Cell growth promoter (described in Table 1) Blood circulation Accelerator (described in Table 1) Purified water Residue (oil phase component) Squalane 20.0% Self-emulsifying glycerin monostearate 4.0% POE (40) Stearic acid 2.0% Behenyl alcohol 2.0% Purified water was added. The total amount was 100 g, and a cream was prepared according to a conventional method.

[0032]

[Table 1]

(1) Bear Improvement Effect (Test Method) The effect was evaluated by continuously applying it to the right eye area of 10 women in their twenties who had outstanding bears under the eyes for 4 weeks. That is, about 0.5 g of the cream of each example having a predetermined composition was applied once a day to the right eye of the subject, and the state of the bear under the eyes before the start of the test and after the end of the test was evaluated according to the following criteria. It was judged. The left eye area was not coated with the sample and was used as a control. The obtained results are shown in Table 2. (Judgment Criteria) Efficacy; Clear and fine texture is observed Effective; Clear but slightly rough texture is observed Slightly effective; Slightly unclear texture is observed Ineffective; Unclear texture is observed (Judgment) ⊙: The proportion of the subjects showing excellent response and efficacy is 8 or more ○: The proportion of the subjects showing excellent response and efficacy is 5 to 7 Δ: Remarkable and effective among the subjects When the ratio showing 2 is from 4 to 4 people; when the ratio showing excellent response and efficacy among the subjects is less than 2 people

(2) Effect of improving fine wrinkles on the outer corners of the eyes (test method) The effect was evaluated by continuously applying it to 10 women in their 20s having fine wrinkles on the outer corners of the eyes at a depth of about 50 to 100 μm for 4 weeks. That is, 1 day a day on the test site of the right outer corner of the subject
Each time, about 0.5 g of the cream of each example was applied, and a replica was collected using a two-agent mixed type replica agent skin cast manufactured by Yamada Cosmetics Co., Ltd. on the outer corners of the eye before and after the test. It was judged according to the standard. The left outer corner of the eye was used as a control without applying the sample. The results obtained are shown in Table 3. (Judgment Criteria) Effective: Significant improvement Effective; Moderate improvement Slightly effective; Mild improvement not effective; No change (judgment) ◎: When the proportion of subjects showing excellent or effective is 8 or more ○ ; When the rate of marked response and efficacy among the subjects is 5 to 7 △: When the rate of marked response and efficacy among the subjects is 2 to 4 ×: Indicates the efficacy and efficacy among the subjects If the ratio is less than 2 people

(3) Swelling Improvement Effect (Test Method) 10 women in their twenties who had a noticeable swelling under the eyes were continuously applied to the right eye area for 4 weeks, and the effect was evaluated. That is, once a day on the subject's cheek region, and below the subject's right eye, 1
Once a day, apply about 0.5 g of each example cream,
The state of swelling under the eyes before the start of the test and after the end of the test was judged according to the following judgment criteria. The left eye area was not coated with the sample and was used as a control. The results obtained are shown in Table 4. (Judgment Criteria) Effective: Significant improvement Effective; Moderate improvement Slightly effective; Mild improvement not effective; No change (judgment) ◎: When the proportion of subjects showing excellent or effective is 8 or more ○ ; When the rate of marked response and efficacy among the subjects is 5 to 7 △: When the rate of marked response and efficacy among the subjects is 2 to 4 ×: Indicates the efficacy and efficacy among the subjects If the ratio is less than 2 people

[0036]

[Table 2]

As is clear from Table 2, the creams of Examples 1 to 6 which belong to the scope of the present invention have a bear improving effect, and particularly when an extract from aloe or almond is added, this improving effect is enhanced. I understand.

[0038]

[Table 3]

As is clear from Table 3, the creams of Examples 1 to 6 which belong to the scope of the present invention have an effect of improving fine wrinkles, and particularly when an extract from aloe or almond is added, this effect of improvement is high. I see.

[0040]

[Table 4]

As is clear from Table 4, the creams of Examples 1 to 6, which are one example of the external preparation for skin of the present invention, have an effect of improving swelling, and in particular, when the extract from aloe or almond is added, the improvement is achieved. You can see that the effect is high.

[0042]

Industrial Applicability As described above, according to the present invention, since the predetermined components are added to Yokuinin or the like, the composition for Yokuinin is a novel use composition, and bears, fine wrinkles and swelling are eliminated. It is possible to provide a skin external preparation for or around the eyes that can be improved.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 35/78 A61K 35/78 H J N Q S T U V A61P 3/02 109 A61P 3/02 109 9 / 00 9/00 17/16 17/16 43/00 107 43/00 107 F term (reference) 4C083 AA111 AA112 AC012 AC072 AC111 AC122 AC182 AD352 AD661 CC05 DD31 EE06 EE07 EE12 EE13 4C086 AA01 AA02 BA09 MA03 MA04 MA05 MA28 MA63 NA14 ZA36 ZA89 ZB22 ZC29 4C088 AB12 AB19 AB26 AB34 AB38 AB40 AB52 AB59 AB86 BA07 BA08 CA03 MA08 MA28 MA63 ZA36 ZA89 ZB22 ZC29

Claims (6)

[Claims] 1. A skin external preparation for the eyes, comprising a mixture of yochinin and / or an extract thereof, a cell growth promoter and a blood circulation promoter. 2. The cell growth promoting agent is an extract from at least one plant selected from the group consisting of aloe, dandelion, senkyu, sokuhaku, carrot and hop, and / or a plant or a combination of these plants. The external preparation for skin according to claim 1, which is: 3. The external skin preparation according to claim 1, wherein the blood circulation promoting agent is vitamin E and / or a derivative thereof. 4. The blood circulation promoter is an extract from at least one plant selected from the group consisting of almond, peanut, perilla and pumpkin, and / or a plant or a combination of these plants. The external preparation for skin according to claim 1 or 2. 5. The external preparation for skin according to any one of claims 1 to 4, which further comprises pentanediol. 6. The method according to claim 1, which is used for an eye area.
The external preparation for skin according to any one of 1 to 6.