WO2012017734A1

WO2012017734A1 - Skin cosmetic

Info

Publication number: WO2012017734A1
Application number: PCT/JP2011/062902
Authority: WO
Inventors: 孝之大村; 智美古川原
Original assignee: 株式会社資生堂
Priority date: 2010-08-05
Filing date: 2011-06-06
Publication date: 2012-02-09
Also published as: JP2012051873A; TW201208711A

Abstract

The objective of the present invention is to provide a skin cosmetic with excellent usability, having such functions as pore shrinking and skin disorder prevention and improvement, as well as an effect of comprehensively improving a wrinkle and tone improving effect. The present invention is characterized in that it contains (A) one or more D-amino acid, derivative and/or salt thereof, and (B) one or more ß-alanine derivative and salt thereof. This skin cosmetic has excellent effects such as pore shrinking and skin disorder prevention and improvement, is able to improve skin wrinkles and tone, and also has excellent usability.

Description

Skin cosmetics

The present invention relates to a skin cosmetic. More specifically, by combining D-amino acid or its derivative or its salt and β-alanine derivative, pore reducing effect to suppress the conspicuous mortar structure of pores, preventing and improving rough skin caused by unsaturated fatty acid The present invention relates to a skin cosmetic which has an effect of improving skin, wrinkle of skin, and elasticity, and also has excellent usability (non-stickiness, moistness, feel of elasticity).

Rough skin is a skin problem caused by external factors such as dryness, ultraviolet rays, irritating substances such as detergents and chemicals, and internal factors such as hormonal balance disturbances, and deterioration of the stratum corneum barrier function. It is accompanied by phenomena such as a decrease in stratum corneum moisture, an increase in epidermis turnover, and roughening of the keratin due to the generation of scaling (scaling). In particular, the roughening of the keratin may worsen the makeup paste, which is a cosmetic problem for many women.

Conventionally, for the purpose of improving rough skin, a method of supplementing the stratum corneum barrier function with an occlusive agent such as petrolatum ointment or a water-in-oil emulsion formulation, a method of supplementing the stratum corneum moisture with a moisturizing agent such as sorbitol, glycerin, alkylene oxide derivatives In addition, methods of suppressing skin inflammation with anti-inflammatory agents such as glycyrrhetinic acid, and methods of activating skin cells with vitamins, hormones, etc. have been used (see Patent Documents 1 to 5).

However, none of the conventional methods as described above have sufficient skin moisture retention ability, and the effect of improving keratin is not only small. In particular, when an occlusive agent is used, it is oily and uncomfortable such as stickiness. There is a drawback that gives a unique feel. On the other hand, even when a moisturizing agent is used, it must be added in a large amount in order to enhance the effect. As a result, there is a problem that an unpleasant feeling such as a sticky feeling or a slimy feeling is given. Furthermore, when animal tissue extracts such as placenta, vitamins, hormones, and the like are used, there are problems in safety related to side effects and the stability over time. In particular, regarding the roughening of the stratum corneum, the situation that the exfoliation of the stratum corneum has not been carried out smoothly has been elucidated, but there has been no appropriate countermeasure.

In addition, human skin tends to cause various problems such as conspicuous pores, rough skin, sagging and wrinkles due to seasonal variation and aging. In recent years, especially for young women, worries about the conspicuous pores have been increasing, and a composition for external application to the skin has been required. However, the mechanism by which pores are conspicuous is not clear, and at present, countermeasures by removing astringent lotion and square plugs are common. In rare cases, the appearance of the foundation is often improved.

However, for example, astringent lotion is intended to tighten the skin, and is due to the action of temporarily lowering the skin surface temperature with alcohol or coagulating proteins with organic acids or the like. Therefore, since the skin is temporarily tightened, the load on the skin is large, and it is not a fundamental solution for conspicuous pores, and the effect is not sufficient. Conventionally, there are reports that glycolic acid and ascorbic acid derivatives have a pore-reducing effect (for example, see Non-Patent Document 1), but there are still many unclear points such as the mechanism of action and the degree of effect.

In addition, horn plug removal is a method of physically removing horn plugs clogged in pores. For example, horn plug removal agent containing a polymer compound having a salt-forming group (Patent Document 6), water-insoluble cyclodextrin polymer Removal using a cosmetic containing cosmetics (Patent Document 7), an angular plug removing cosmetic containing 50% by mass or more of an oil having a viscosity of 5 to 80 mPa · s / 25 ° C. (Patent Document 8), and the like has been proposed.
However, in such a method of removing the horn plug, the physical force may damage the skin, and the side effect on the skin sometimes becomes a problem. In addition, the effect was temporary, and the plug was immediately regenerated, and when the plug was removed, the pores were conversely enlarged, and the effect was not always sufficient.

Furthermore, β-alanine derivatives have been conventionally blended into cosmetics as an active ingredient for the skin, and it is generally known that when a β-alanine derivative is blended in cosmetics, moisture is obtained. Such a cosmetic formulation of β-alanine derivative is described in Patent Document 9, and it is shown that β-alanine derivative has a skin keratinization suppressing effect, a pore reducing effect, a skin roughness improving / preventing effect, and the like. ing. However, when the β-alanine derivative was used, the effect of reducing skin pores and the effect of improving / preventing rough skin were recognized, but the effect of improving wrinkles and burrs was not fully recognized.

JP-A-6-293625 Japanese Unexamined Patent Publication No. 7-277743 JP-A-9-95432 Japanese Patent No. 3660656 JP 2009-227645 A JP-A-5-97627 JP-A-5-105619 JP 2002-241260 A Japanese Laid-Open Patent Publication No. 2006-312597

The present invention has been made in view of the above problems, and has a function of comprehensively improving functions such as pore reduction, rough skin prevention, improvement, and wrinkle and beam improvement, and has excellent usability. The purpose is to provide cosmetics.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have blended D-amino acid and β-alanine derivative, and are excellent in effects such as pore reduction, rough skin prevention, improvement, and skin wrinkle. The present inventors have found that a skin cosmetic that can improve the beam and that is excellent in usability can be obtained.
That is, the present invention relates to a skin makeup containing (A) one or more of D-amino acids, derivatives and / or salts thereof, and (B) one or more of β-alanine derivatives and salts thereof. Provide a fee.

The skin cosmetic of the present invention comprises component (A) one or more of D-amino acids or derivatives and / or salts thereof, and component (B) one or more of β-alanine derivatives and salts thereof. In combination, it has an advantageous effect of comprehensively improving wrinkle and beam improvement functions, as well as excellent usability. .

Hereinafter, the present invention will be described in detail.
The skin cosmetic of the present invention essentially contains one or more of D-amino acids, derivatives and / or salts thereof (component (A): hereinafter may be abbreviated as “D-amino acids”). Yes.

As is well known, amino acids have L-forms and D-forms as optical isomers, and natural proteins are those in which L-amino acids are peptide-bonded. Except for some exceptions such as bacterial cell walls, it has been considered that only L-amino acids exist in the body of mammals including humans, and living organisms use only L-amino acids. Therefore, until now, only L-amino acids have been studied with academic or industrial attention.
Exceptionally, D-amino acids were used in the following cases: (1) When used as a raw material for antibiotics produced by bacteria, (2) L-amino acids and D-amino acids obtained in equivalent amounts when chemically synthesizing amino acids In order to save the cost of fractionating only the L-amino acid from the amino acid mixture (racemate), it may be contained in a food additive formulated as a DL-amino acid mixture as it is.

Recently, in humans, it has been clarified that D-aspartic acid (D-Asp), which should not be originally present in the eye lens, brain, or skin, increases with aging, and onset of cataracts or Alzheimer's disease. (Tadahiro Kinouchi et al., “Protein Nucleic Acid Enzyme”, Volume 50, No. 5 (2005), pages 453-560). Also in skin, it has been found that D-Asp accumulates due to aging or ultraviolet irradiation, and it has been proposed to apply D-Asp as a molecular marker for knowing skin damage due to aging or ultraviolet light (Noriko Fujii, Cosmetology Research Report No. 13 (2005) However, there are no known examples in which D-amino acids are actively used as physiologically active substances.
The present invention is characterized in that D-amino acid, which has not been conventionally blended in cosmetics, particularly skin cosmetics, is blended as an essential component due to the circumstances as described above.

The D-amino acids (component (A)) used in the present invention are not particularly limited as long as they are D isomers, but those having a skin improvement effect per se are preferred. Specifically, D-aspartate, laminin 332 production promotion effect, collagen production promotion effect D-alanine, barrier recovery function, wrinkle formation reduction effect, skin roughness reduction with antioxidant effect and collagen production promotion effect D-glutamic acid with an effect, D-serine with an effect of reducing UV damage, D-hydroxyproline with an effect of promoting laminin 332 production, D-cysteine with an effect of reducing UV damage, an effect of reducing UV damage Examples thereof include D-methionine and D-proline, and D-hydroxyproline in which a melanin production inhibitory effect is recognized.

The D-amino acids used in the present invention may be synthesized or commercially available.
As a method for producing a D-amino acid, for example, a method obtained by allowing a bacterium-derived D-aminoacylase to act on an acylated amino acid is known (see JP-A-11-113582).
The blending amount of D-amino acids in the skin cosmetic of the present invention is preferably 0.1 to 5.0% by mass with respect to the total amount of the skin cosmetic. If it is less than 0.1% by mass, it is difficult to obtain a cosmetic that is characteristic of the present invention and is excellent in skin improvement effect. Even if it exceeds 5.0% by mass, the effect of the present invention is obtained. Further enhancement of the skin improvement effect cannot be obtained.

Next, the β-alanine derivative or a salt thereof (component (B)), which is another essential component of the present invention, will be described in detail.
The β-alanine derivative as the component (A) used in the present invention is not particularly limited as long as it can be used in cosmetics. For example, 3- (1′-piperidine) -propionic acid, β-alanine amide, N-monomethyl-β-alanine, N-cyclohexyl-β-alanine, N-cyclohexylmethyl-β-alanine, N-cyclohexyl-N-methyl-β-alanine, N-cyclohexylcarbonyl-β-alanine N- (2′-pyridyl) -β-alanine, N-nicotinoyl-β-alanine, N-benzyloxycarbonyl-β-alanine, N-benzyl-β-alanine, N-benzenesulfonyl-β-alanine, N -Benzoyl-β-alanine, Np-anisoyl-β-alanine (N-4'-methoxybenzoyl-β-alanine), Nm- Nisoyl-β-alanine (N-3′-methoxybenzoyl-β-alanine), No-anisoyl-β-alanine (N-2′-methoxybenzoyl-β-alanine), N-3 ′, 4 ′, Examples thereof include 5′-trimethoxybenzoyl-β-alanine, N-phenylacetyl-β-alanine, and salts thereof. Of these, 3- (1′-piperidine) -propionic acid or a salt thereof is most preferable in terms of drug stability and effects on the skin.

Examples of salts of β-alanine derivatives include alkali metal salts (sodium salt, potassium salt, lithium salt, etc.), alkaline earth metal salts (calcium salt, magnesium salt, etc.), ammonium salts, organic amine salts (monoethanolamine). Salt, diethanolamine salt, triethanolamine salt, etc.). (A) A component can use 1 type (s) or 2 or more types.

The blending amount of the β-alanine derivative (component (B)) in the skin cosmetic of the present invention is preferably 0.1 to 5.0% by mass in the skin cosmetic of the present invention. If the amount is less than 0.1% by mass, the effect may not be sufficiently obtained. Even if the amount exceeds 5.0% by mass, the effect of the present invention is not further enhanced, and stability may be affected. Conceivable.

In the skin cosmetic according to the present invention, components usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as oil, surfactant, powder, coloring material, water, alcohols, thickener, chelating agent, silicones , Antioxidants (antioxidants), ultraviolet absorbers, moisturizers, fragrances, various medicinal components, preservatives, neutralizers, pH adjusters and the like can be optionally blended as necessary.

Of the above optional ingredients, specific examples of the oil include, for example, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat Germ oil, sasanqua oil, castor oil, flaxseed oil, safflower oil, cottonseed oil, evening primrose oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, Liquid oils such as germ oil, triglycerin, glycerin trioctanoate, glycerin triisopalmitate, cocoa butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel oil, pork tallow , Solid oils such as owl kernel oil, hydrogenated oil, owl, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, lanolin, lanolin acetate, liquid lano , Sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, polyoxyethylene (hereinafter referred to as POE) lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol Waxes such as ether, liquid paraffin, ozokerite, squalene, paraffin, ceresin, squalane, petrolatum, microcrystalline wax and other hydrocarbons, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, Hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, lactic acid Listyl, Lanolin acetate, Isocetyl stearate, Isocetyl isostearate, Cholesteryl 12-hydroxystearylate, Ethylene glycol di2-ethylhexylate, Dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, Neopentyl glycol dicaprate, Malic acid Diisostearyl, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaerythritol tetra2-ethylhexylate, glyceryl tri-2-ethylhexylate, trimethylolpropane triisostearate, Cetyl-2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-he Ptyl undecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, acetoglyceride, palmitic acid-2-heptylundecyl, adipic acid diisopropyl, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, adipic acid di-2- Ester oils such as heptylundecyl, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, lanolin fatty acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaene Higher fatty acids such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerol ether (batyl alcohol), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl Linear or branched higher alcohols such as dodecanol, isostearyl alcohol and octyldodecanol, silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane, perfluorocarbons such as perfluorohexane and triperfluoro-n-butylamine or perfluoro A polyether etc. can be mentioned.

Examples of the surfactant include soap bases, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, POE lauryl sulfate triethanolamine, and POE sodium lauryl sulfate. Alkyl ether sulfate ester salts such as N-acyl sarcosine acid such as sodium lauroyl sarcosine, higher fatty acid amide sulfonic acid such as sodium N-myristoyl-N-methyl taurate, coconut oil fatty acid methyl tauride sodium, POE stearyl ether phosphoric acid, etc. Phosphoric acid ester salts, sulfosuccinates such as monolauroyl monoethanolamide POE sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, Alkyl benzene sulfonates such as sodium dodecylbenzene sulfonate and triethanolamine linear dodecyl benzene sulfonate, N-acyl glutamate such as N-stearoyl glutamate monosodium, monosodium N-stearoyl glutamate, hydrogenated coconut oil fatty acid sodium glycerine sulfate, etc. Higher fatty acid ester sulfates, sulfated oils such as funnel oil, POE alkyl ether carboxylic acids, POE alkyl allyl ether carboxylates, higher fatty acid ester sulfonates, secondary alcohol sulfates, higher fatty acid alkylolamide sulfates Anionic surfactants such as ester salts, sodium lauroyl monoethanolamide succinate, sodium caseinate; stearyltrimethylammonium chloride, lauryl chloride Alkyltrimethylammonium salts such as limethylammonium, dialkyldimethylammonium salts such as distearyldimethylammonium chloride, alkylpyridinium salts such as cetylpyridinium chloride, alkylquaternary ammonium salts, alkyldimethylbenzylammonium salts, alkylisoquinolinium salts , Cationic surfactants such as dialkyl morpholinium salts, POE alkyl amines, alkyl amine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride; 2-cocoyl-2-imidazolinium hydroxide-1- Amphoteric surfactants such as imidazoline-based amphoteric surfactants such as carboxyethyloxy disodium salt, betaine-based surfactants such as amide betaine and sulfobetaine; sorbitan monooleate, Sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan trioleate, mono cottonseed oil fatty acid glycerin, glyceryl monostearate, glyceryl sesquioleate, glyceryl monostearate malate, etc. Lipophilic nonionic surfactants such as glycerin polyglycerin fatty acids, propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ether, POE / methylpolysiloxane copolymer; POE sorbitan mono POE sorbitan fatty acid esters such as oleate, POE sorbitan monostearate, POE sorbit monolaurate, POE sorbit monooleate, POE POE sorbite fatty acid esters such as rubit monostearate, POE glycerin monooleate, POE glycerin fatty acid esters such as POE glycerine distearate, POE fatty acid esters such as POE monooleate, POE distearate, POE monodiolate, POE lauryl ether POE alkyl ethers such as POE oleyl ether and POE cholestanol ester, POE alkyl phenyl ethers such as POE octyl phenyl ether and POE nonyl phenyl ether, and POE / polyoxypropylene (hereinafter referred to as POP). ) POE / POP alkyl ethers such as monobutyl ether, POE / POP cetyl ether, POE / POP glycerin ether, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil maleic acid, etc. POE castor oil hardened castor oil derivative, POE beeswax lanolin derivative such as POE sorbite beeswax, alkanolamide such as coconut oil fatty acid diethanolamide, fatty acid isopropanolamide, POE propylene glycol fatty acid ester, POE fatty acid amide, POE alkylamine, sucrose fatty acid Examples thereof include hydrophilic nonionic surfactants such as esters and alkylethoxydimethylamine oxide.

Examples of the powder include mica, talc, kaolin, sericite (sericite), muscovite, phlogopite, synthetic mica, saucite, biotite, lithia mica, synthetic mica, calcium carbonate, magnesium carbonate, and anhydrous silicic acid ( Silica), aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, aluminum oxide, barium sulfate, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, oxide Zinc, titanium mica (titanium oxide coated mica), fish phosphorus foil, bismuth oxychloride, boron nitride, red 228, red 226, blue 404, polyethylene powder, polymethyl methacrylate powder, polyamide resin powder (nylon powder) , Cellulose powder, organopolysiloxane elastomer, aluminum Mention may be made of powder, the copper powder and the like.

Examples of alcohols include lower alcohols such as methanol, ethanol, propanol, and isopropanol; cholesterol, sitosterol, lanosterol, and the like.
Examples of thickeners include, for example, plant polymers such as gum arabic, tragacanth cam, galactan, carop gum, guar gum, carrageenan, pectin, agar, starch (corn, wheat, potato, rice), and microbial polymers such as dextran and pullulan. Molecules, starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, animal-based polymers such as collagen, casein, and gelatin, methylcellulose, nitrocellulose, ethylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, Cellulosic polymers such as crystalline cellulose, alginic acid polymers such as sodium alginate and propylene glycol alginate, polyvinyl methyl ester Vinyl polymer such as tellurium and carboxyvinyl polymer, POE polymer, POE polyoxypropylene copolymer polymer, acrylic polymer such as sodium polyacrylate and polyacrylamide, polyethyleneimine, cationic polymer, bentonite And water-soluble polymers such as inorganic water-soluble polymers such as magnesium aluminum silicate, laponite, hectorite, and silicic anhydride.

Examples of chelating agents include citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, ethyleneglycoldiaminetetraacetic acid, diethylenetriaminepentaacetic acid, phytic acid, polyphosphoric acid, Examples thereof include metaphosphoric acid, analogs thereof, alkali metal salts and carboxylic acid esters thereof.

Examples of the ultraviolet absorber include benzoic acid ultraviolet absorbers such as paraaminobenzoic acid; anthranilic acid ultraviolet absorbers such as methyl anthranilate; salicylic acid ultraviolet absorbers such as octyl salicylate; isopropyl paramethoxycinnamate, para Examples thereof include cinnamic acid-based ultraviolet absorbers such as octyl methoxycinnamate; ultraviolet absorbers such as urocanic acid and ethyl urocanate.

Examples of the humectant include polyethylene glycol (hereinafter referred to as PEG), propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, xylitol, maltitol, maltose, D-mannitol, glucose, Examples include fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, and cyclodextrin.

Examples of medicinal ingredients include vitamin A oil, retinol, retinol palmitate, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, nicotinic acid dl-α-tocopherol, ascorbic acid magnesium phosphate, vitamin D ₂ , dl-α- Vitamins such as tocopherol, pantothenic acid and biotin; anti-inflammatory agents such as azulene and glycyrrhizin; whitening agents such as arbutin; hormones such as estradiol; astringents such as zinc oxide and tannic acid; refreshing products such as L-menthol and camphor Agent: Other lysozyme chloride, pyridoxine hydrochloride, sulfur and the like can be blended. Furthermore, various extracts showing various medicinal effects can be blended. That is, there can be mentioned, for example, dokudami extract, apricot extract, licorice extract, peony extract, button pi extract, loofah extract, cypress extract, eucalyptus extract, clove extract, maronier extract, cornflower extract, seaweed extract, thyme extract and the like.

Examples of preservatives include benzoic acid, salicylic acid, paraoxybenzoic acid esters (methylparaben, ethylparaben, butylparaben, etc.), sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide. , Photosensitive element, phenoxyethanol, and the like.

Other neutralizing agents such as 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, potassium hydroxide, triethanolamine, sodium carbonate; lactic acid PH adjusters such as citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogen carbonate ammonium hydrogen carbonate; antioxidants such as ascorbic acid, α-tocopherol, carotenoids and the like may be incorporated into the preparation of the present invention. it can.

In addition, the said component is an illustration and is not limited to these. Further, these components can be appropriately combined and blended in accordance with a prescription according to a desired form.

Examples of the skin cosmetic preparation of the present invention include aqueous solutions, solubilization systems, emulsification systems, oil-liquid systems, gel systems, ointment systems, aerosol systems, water-oil two-layer systems, water-oil-powder three-layer systems. A wide range of dosage forms can be taken.
By using a composition such as a keratinization inhibitor, a pore-reducing agent, a rough skin prevention / improving agent, a skin external composition, etc. according to the present invention, the keratinization is suppressed and the skin condition is maintained in a good state. It is also possible to provide a skin cosmetic that improves and improves the skin to improve wrinkles and elasticity.

The emulsified skin cosmetic of the present invention can be obtained by a conventional method such as preparing an oil phase and an aqueous phase in advance and emulsifying by mixing and stirring while gradually adding the oil phase to the aqueous phase thus prepared. The manufacturing method is not limited to these examples.

The skin cosmetic of the present invention is preferably provided as a milky product such as an emulsified foundation or sunscreen emulsion, or a creamy product such as a skin cream.

The present invention will be described more specifically with reference to the following examples. However, the present invention is not limited to these examples. All blending amounts are mass% unless otherwise specified.
First, the test method and evaluation method used in this example will be described.

<Confirmation Tests 1 and 2> Human pore reduction effect An experiment in which a sample was applied twice a day for one month using a normal man's cheeks was carried out by five people in each group.
First, the product of the present invention and the comparative product were applied one by one. Replicas were collected before and after continuous application, and changes in the shape of pores at the same site were observed with a three-dimensional laser scanning microscope. The size of the pores is evaluated on the basis of visual evaluation in 13 stages (1 to 13 (the larger the number, the larger the pores)) (confirmation test 1), and the difference between the scores before and after application (after application-before application) The effectiveness of each sample was examined by calculating and using this as a replica judgment value (confirmation test 2).
<Confirmation test 3 to 7> Usability, wrinkle improvement effect, and skin irritation feeling Each test product was used by 10 specialist panels for usability (confirmation test 3); wrinkle improvement effect after 2 weeks of continuous use ( Confirmation test 4); Wrinkle improvement effect after 4 weeks of continuous use (Confirmation test 5); Feeling of feeling of elasticity / skin feeling after 2 weeks of continuous use (Confirmation test 6); A feeling of use (confirmation test 7) in which the skin feels a bite was determined and evaluated according to the following criteria.

<Confirmation test 3> Usability (no stickiness during use)
◎: 8 or more people who feel that there is no stickiness ○: 5 to 7 people who feel that there is no stickiness △: 3 people who feel that there is no stickiness ×: Feel that there is no stickiness Less than 2 people

<Confirmation test 4> Wrinkle improvement effect after 2 weeks of continuous use ◎: More than 8 people who felt wrinkle improvement effect ○: 5 to 7 people who felt wrinkle improvement effect Δ: Wrinkle improvement effect 3 to 4 people who feel that there is: ×: 2 or less people who feel that wrinkle improvement effect

<Confirmation test 5> Wrinkle improvement effect after 4 weeks of continuous use ◎: 8 or more people who felt wrinkle improvement effect ○: 5 to 7 people who felt wrinkle improvement effect Δ: Wrinkle improvement effect 3 to 4 people who feel that there is: ×: 2 or less people who feel that wrinkle improvement effect

<Confirmation test 6> Feeling of stickiness / skin feel after 2 weeks of continuous use ◎: More than 8 people feel wrinkle improving effect ○: 5 people feel wrinkle improving effect 7 people △: 3 to 4 people who felt wrinkle improvement effect ×: 2 or less people who felt wrinkle improvement effect

<Confirmation test 7> Feeling of stickiness and skin feel after 4 weeks of continuous use ◎: More than 8 people feel that there is an improvement effect in the circle ○: 5 people feel that there is an improvement effect in the beam ~ 7 people △: 3 to 4 people who felt that it had a beam improving effect ×: 2 people or less who felt that it had a beam improving effect

Examples 1 to 10 and Comparative Examples 1 to 10
Skin care creams, which are skin cosmetics, having the compositions shown in Tables 1 to 4 below were produced by a conventional method, and evaluated according to the evaluation methods and standards in the confirmation tests 1 to 7 described above. The results are shown in Tables 1 to 4, respectively.

As is apparent from Tables 1 to 4, component (A) D-amino acid, one or more of its derivatives and / or salts, which are essential components of the present invention, component (B) β-alanine derivative and its Examples 1 to 10 of the present invention containing one or more salts can provide skin cosmetics that are excellent in usability but excellent in the effect of reducing pores and improving wrinkles and elasticity. Comparative Examples 1 to 10 lacking one or both of the essential components (A) and (B) of the invention lack any of the above usability, pore reduction effect, and wrinkle / beam improvement effect.

Hereinafter, other examples of the present invention will be described.
In addition, when the effect test similar to the above was performed also about the following examples, the outstanding result was obtained in all.

Example 11: Emollient cream (O / W type)
Ingredient Amount (% by mass)
(1) Stearyl alcohol 2.0
(2) Behenyl alcohol 1.0
(3) Hydrogenated polyisobutene 4.0
(4) Squalane 7.0
(5) Dineopentanoic acid tripropylene glycol 2.0
(6) 1,3-butylene glycol 5.0
(7) Dipropylene glycol 3.0
(8) Dimethyl silicone (5 mPa · s) 5.0
(9) Polyethylene glycol 1500 1.0
(10) Mono coconut oil fatty acid polyoxyethylene (20) sorbitan 3.0
(11) Glyceryl monostearate 2.0
(12) Ethylparaben 0.1
(13) Butylparaben 0.1
(14) Tocopherol 0.1
(15) Component (A) D-hydroxyproline 2.0
(16) Component (B) N-methyl-β-alanine 2.0
(17) Perfume appropriate amount (18) Ion exchange water remaining

<Production method>
(6), (7), (9), (12) to (16) were added to (18), and the mixture was heated to 70 ° C. Subsequently, the oil phases (1) to (5), (8), (10), (11) and (17) were prepared at 70 ° C. This was added to the previous aqueous phase, the emulsified particles were made uniform with a homomixer, deaerated, cooled and filtered to obtain the target emollient cream (O / W type).

Example 12: emulsion component blending amount (% by mass)
(1) Dimethyl silicone 1.5 mPa · s 3.0
(2) Isododecane 5.0
(3) Squalane 2.0
(4) Olefin oligomer 1.0
(5) Isotridecyl isononanoate 2.0
(6) PEG-20 stearate 0.3
(7) Sorbitan sesquistearate 0.1
(8) Glyceryl monostearate (self-emulsifying type) 0.3
(9) Perfume appropriate amount (10) Dipropylene glycol 1.0
(11) 1,3-butylene glycol 4.0
(12) Glycerin 2.0
(13) Carboxyvinyl polymer 0.1
(14) Alkyl-modified carboxyvinyl polymer 0.05
(15) Potassium hydroxide appropriate amount (16) Component (A) D-methionine 0.5
(17) Component (B) N- (4′-methoxybenzoyl) -β-alanine 3.5
(18) Horsetail extract 0.1
(19) Hamelis extract 0.1
(20) Ethanol 5.0
(21) Phenoxyethanol 0.3
(22) Residual ion exchange water

<Production method>
(10) to (22) are uniformly dissolved at 70 ° C. (aqueous phase). Next, (1) to (9) are uniformly dissolved at 70 ° C., added to the previous aqueous phase, and uniformly dispersed with a disper. Deaeration, cooling, and filtration were performed to obtain the desired emulsion.

Example 13: Emollient cream (O / W type)
Ingredient Amount (% by mass)
(1) Behenyl alcohol 0.1
(2) Batyl alcohol 0.5
(3) Hydrogenated polyisobutene 4.0
(4) Liquid paraffin 5.0
(5) Isodecyl neopentanoate 2.0
(6) Decamethylcyclopentasiloxane 5.0
(7) Isohexadecane 3.0
(8) Fragrance 0.1
(9) Polyethylene glycol 20000 1.0
(10) Ethylparaben 0.1
(11) Butylparaben 0.1
(12) Tocopherol 0.1
(13) (Dimethylacrylamide / acryloyldimethyltaurine sodium) copolymer 0.4
(14) Component (A) D-serine 2.5
(15) Component (B) N-benzenesulfonyl-β-alanine 0.1
(16) Hawthorn extract 0.1
(17) Heartworm leaf extract 0.1
(18) Walnut extract 0.1
(19) Clove extract 0.1
(20) Juyaku extract 0.1
(21) Altea root extract 0.1
(22) Murasaki root extract 0.1
(23) 1,3-butylene glycol 3.0
(24) Glycerol 3.0
(25) Ion exchange water remaining

<Production method>
(9) to (24) were added to (25), and the mixture was heated to 70 ° C. Next, the oil phases (1) to (8) were prepared at 70 ° C. This was added to the aqueous phase and the emulsified particles were made uniform with a homomixer. Deaeration, cooling, and filtration were performed to obtain the target emollient cream (O / W type).

Example 14: Emollient cream (W / O type)
Ingredient Amount (% by mass)
(1) Microcrystalline wax 2.0
(2) Liquid paraffin 20.0
(3) Hydrogenated rape seed oil 5.0
(4) Polyglyceryl-2 dioleate-2 5.0
(5) Butylparaben 0.1
(6) Fragrance 0.1
(7) Dimethyl silicone 2 mPa · s 10.0
(8) Sodium glutamate 1.6
(9) Component (A) D-glutamic acid 0.5
(10) Component (A) D-aspartic acid 1.0
(11) Propylene glycol 3.0
(12) Component (B) N-nicotinoyl-β-alanine 4.5
(13) Chamomile extract 0.1
(14) Clara extract 0.1
(15) Ion exchange water remaining

<Production method>
A part of (15) and (8), (9), (10) and (4) is heated to 50 ° C. to be uniform (amino acid gel). Next, the above amino acid gel is uniformly dispersed with a disper in one obtained by dissolving the oil phases (1) to (3) and (5) to (7) at 70 ° C. Further, the remaining (15) and (11) to (14) heated to 70 ° C. are added to this dispersion with sufficient stirring, and uniformly emulsified with a disper. Deaeration, cooling, and filtration were performed to obtain the target emollient cream (W / O type).

Example 15: Comprehensive cream with anti-aging and whitening effect (O / W type)
Ingredient Amount (% by mass)
(1) Palmitic acid 2.0
(2) Cetyl alcohol 1.5
(3) Vaseline 3.0
(4) Squalane 5.0
(5) Triethylhexanoin 2.0
(6) Sorbitan oleate 2.0
(7) Fragrance 0.1
(8) Methyltrimethicone 10.0
(9) Tranexamic acid 2.0
(10) (sodium acrylate / acryloyldimethylsodium)
Copolymer 0.3
(Product name: SIMULGEL EG, manufactured by SEPIC)
(11) Methylparaben 0.1
(12) Phenoxyethanol 0.1
(13) Component (A) D-aspartic acid 1.0
(14) Component (B) N- (1′-piperidine) -propionic acid 1.0
(15) Asenyaku extract 0.1
(16) Merirot extract 0.1
(17) Ion exchange water remaining

<Production method>
(9) to (16) were added to (17), and the mixture was heated to 70 ° C. Next, the oil phases (1) to (8) were prepared by heating to 70 ° C. This oil phase is added to the previously prepared aqueous phase, and the emulsified particles are made uniform with a homomixer. Deaeration, cooling, and filtration were carried out to obtain a desired general cream (O / W type) having anti-aging and whitening effects.

Example 16: Emollient cream (W / O type)
Ingredient Amount (% by mass)
(1) Squalane 3.0
(2) Diethylhexyl succinate 5.0
(3) isononyl isononanoate 3.0
(4) Microcrystalline wax 1.0
(5) Disteardimonium hectorite 2.0
(6) PEG-10 Dimethicone 2.0
(7) Decamethylcyclopentasiloxane 10.0
(8) Dimethyl silicone 6 mPa · s 2.0
(9) Fragrance 0.1
(10) 1,3-butylene glycol 5.0
(11) Glycerin 5.0
(12) Component (A) D-Serine 2.0
(13) Component (B) N- (3 ′, 4 ′, 5′-trimethoxy-
Benzoyl-β-alanine 1.0
(14) Ethylparaben 0.1
(15) Phenoxyethanol 0.2
(16) Ethyl vitamin C 0.1
(17) Wild time extract 0.1
(18) Tea leaf extract 0.1
(19) Residual ion exchange water

<Production method>
(1) to (9) are prepared at 70 ° C. and uniformly dispersed and dissolved to obtain an oily gel. Add (10) to (18) to (19), dissolve uniformly, and prepare at 70 ° C. (aqueous phase). This aqueous phase is gradually added to the previously prepared oil gel with sufficient stirring. Emulsified particles are uniformly prepared with a disper. Deaeration, cooling, and filtration were performed to obtain the target emollient cream (W / O type).

Example 17: Gel-like cosmetic liquid ingredient content (mass%)
(1) Polyacrylamide 2.0
(Product name: SEPIGEL 305, manufactured by SEPIC)
(2) Isododecane 3.0
(3) Dimethicone 2mPa · s 0.5
(4) Polyoxyethylene (20) behenyl ether 0.5
(5) Ethanol 5.0
(6) Phenoxyethanol 0.1
(7) Fragrance 0.1
(8) Ion exchange water Residual (9) Glycerin 3.0
(10) 1,3-butylene glycol 3.0
(11) Component (A) D-hydroxyproline 0.5
(12) Component (B) N-cyclohexylcarbonyl-β-alanine 0.5
(13) Byaclenca extract 0.1
(14) Tokyo extract 0.1
(15) Button extract 0.1
(16) Artemisia extract 0.1

<Production method>
To the aqueous phase in which (1) and (5) to (16) are uniformly dissolved, the mixture of (2) to (4) is added and dispersed uniformly with a disper. Deaeration and filtration were performed to obtain the desired gel-like serum.

Claims

Skin makeup characterized by containing (A) one or more of D-amino acids, derivatives and / or salts thereof, and (B) one or more of β-alanine derivatives and salts thereof Fee.
2. The D-amino acid is one or more selected from D-glutamic acid, D-alanine, D-methionine, D-hydroxyproline, D-aspartic acid, D-cysteine, and D-proline. The skin cosmetics described.
β-alanine derivatives are 3- (1′-piperidine) -propionic acid, β-alanine amide, N-monomethyl-β-alanine, N-cyclohexyl-β-alanine, N-cyclohexylmethyl-β-alanine, N- Cyclohexyl-N-methyl-β-alanine, N-cyclohexylcarbonyl-β-alanine, N- (2′-pyridyl) -β-alanine, N-nicotinoyl-β-alanine, N-benzyloxycarbonyl-β-alanine, N-benzyl-β-alanine, N-benzenesulfonyl-β-alanine, N-benzoyl-β-alanine, Np-anisoyl-β-alanine (N-4′-methoxybenzoyl-β-alanine), N- m-Anisoyl-β-alanine (N-3′-methoxybenzoyl-β-alanine), No-anisoyl-β-alanine N-2′-methoxybenzoyl-β-alanine), N-3 ′, 4 ′, 5′-trimethoxybenzoyl-β-alanine and N-phenylacetyl-β-alanine The skin cosmetic according to claim 1 or 2, wherein
The blending amount of one or more of (A) D-amino acid, derivative and / or salt thereof is 0.1 to 5.0% by mass, (B) β-alanine derivative and The skin cosmetic according to any one of claims 1 to 3, wherein the blending amount of one or more of the salts is 0.1 to 5.0% by mass.