JP2007332089A - External preparation for skin for enhancing skin barrier - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a technique for repairing skin barrier tissue. <P>SOLUTION: The external preparation for the skin contains (1) α,ε-bis(γ-N-(10-30C)acyl-glutamyl)lysine and/or a salt thereof, and (2) L-carnitine and/or a salt thereof. The (10-30C)acyl group is preferably a lauroyl group, and the L-carnitine and/or the salt thereof is preferably L-carnitine chloride. The external preparation for the skin preferably further contains a component selected from glycerol, 1,2-pentanediol, 1,2-hexanediol and diglycerol, and more preferably contains 5-20 mass% glycerol. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a skin external preparation, and more particularly to a skin external preparation suitable for cosmetics including quasi drugs.

  In recent years, it is an era of stress overload, and is said to be an era in which the effects of the stress on the living body are greatly manifested by rapid increases in mental stress and environmental stress. For example, the number of suicides in Japan greatly exceeds 30,000, and it is said that there is a social stress overload. Such an overload of stress affects the human body itself, and one of the typical symptoms is a decrease in skin barrier function and the onset of atopic dermatitis accompanying it. Inflammation that occurs following such a decrease in skin barrier function, even if the inflammation is suppressed by an anti-inflammatory agent, the decrease in skin barrier function, which is the root cause, is not resolved, so the skin migrates very well do not do. Therefore, it took a long time to heal such dermatitis. For the purpose of promoting the healing of such dermatitis, as one method, a method of constructing a moisturizing protective film on the skin has been devised (for example, Patent Document 1, Patent Document 2, Patent Document 3, (See Patent Document 4). With such a technology, it was possible to construct a water-retaining protective film on the skin, suppress the contact of substances that cause irritation, and prevent the progression of inflammation, but it was not possible to repair the skin barrier tissue itself. It wasn't. In other words, it can be said that development of a technique for repairing the skin barrier tissue has been desired.

  On the other hand, a technique in which cosmetics contain N-acylamino acids that are related to lysine or glutamic acid as the amino acids is already known (see, for example, Patent Document 5), but α, ε-bis (γ -N- (C10-C30) acylglutamyl) lysine and / or a salt external preparation such as a cosmetic containing the salt is not known at all, and L-carnitine and / or a salt thereof has an anti-inflammatory effect. Are known as active ingredients for cosmetics, and the technology for inclusion in cosmetics is already known (see, for example, Patent Document 6, Patent Document 7, and Patent Document 8), 1) α, No skin external preparation containing ε-bis (γ-N- (C10-30) acylglutamyl) lysine and 2) L-carnitine and / or a salt thereof is known at all, and such skin external use is not known. Agent is skin It not at all is known also to be excellent in effect allowed to repair the barrier organization.

JP-A-10-29920 Japanese Patent Laid-Open No. 10-17433 Japanese Patent Laid-Open No. 10-17430 JP 9-315949 A JP 2002-47123 A JP 2005-53835 A JP 2004-242509 A JP 2004-339144 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide a technique for repairing a skin barrier tissue.

In view of such a situation, the present inventors have sought for a technique for repairing the skin barrier tissue and have made extensive research efforts. 1) α, ε-bis (γ-N- It has been found that an external preparation for skin containing 30) acylglutamyl) lysine and 2) L-carnitine and / or a salt thereof has such an action, thereby completing the invention. That is, the present invention is as follows.
(1) 1) containing α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine and / or a salt thereof, and 2) L-carnitine and / or a salt thereof. And skin external preparation.
(2) The skin external preparation according to (1), wherein the acyl group having 10 to 30 carbon atoms is a lauroyl group.
(3) The external preparation for skin according to (1) or (2), wherein the L-carnitine and / or a salt thereof is L-carnitine chloride.
(4) The skin external preparation according to any one of claims 1 to 3, comprising one or more selected from polyhydric alcohols shown in the following group A.
(A) 5 to 20% by mass of glycerin, 1,2-pentanediol, 1,2-hexanediol, diglycerin (5) glycerin, and the external preparation for skin according to (4).
(6) The skin external preparation according to any one of (1) to (5), further comprising a polymer or copolymer containing methacryloyloxyethyl phosphorylcholine as a constituent monomer.

  According to the present invention, a technique for repairing a skin barrier tissue can be provided.

(1) 1) α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine which is an essential component of the external preparation for skin of the present invention is α, ε-bis (Γ-N- (C10-30) acylglutamyl) lysine is contained as an essential component. Such a component may contain a free form or may be contained in the form of a salt. These salts can be used without any particular limitation as long as they are used in skin external preparations, for example, alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium salts and magnesium salts. Preferred examples include organic amine salts such as ammonium salt, triethylamine salt, triethanolamine salt, and monoethanolamine salt, and basic amino acid salts such as lysine salt and alginate. The acyl group has 10 to 30 carbon atoms. Such an acyl group may be linear, branched or cyclic, and may be saturated or unsaturated. good. Specific examples of the acyl group include, for example, decanoyl group, lauroyl group, myristoyl group, palmitoyl group, stearoyl group, behenoyl group, isostearoyl group, oleoyl group, linoloyl group, etc. Particularly preferred. Α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine has two acyl groups, and the two acyl groups may be the same or different. May be. α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine can be produced, for example, by the following procedure. That is, glutamic acid is reacted with acyl chloride in the presence of an alkali such as triethylamine to obtain N-acyl glutamic acid. Thereafter, it can be produced by condensing lysine at a molar ratio of 2: 1 in the presence of a peptide synthesis reagent such as DCC. The reaction product thus obtained can be purified by silica gel column chromatography or the like. Preferred examples of the elution solvent for silica gel column chromatography include a chloroform-methanol mixed solution system. The structure of such α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine is shown in Formula 1. In addition, as a salt of such a component, any salt used in an external preparation for skin can be used without any particular limitation. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth such as calcium salt and magnesium salt, etc. Preferred examples include organic metal salts such as metal salts, ammonium salts, triethylamine salts, triethanolamine salts and monoethanolamine salts, and basic amino acid salts such as lysine salts and alginates.

式１（但し、式中Ｒ１、Ｒ２はそれぞれ独立に炭素数９〜２９のアルキル基乃至はアルケニル基を表す。）

Formula 1 (wherein, R 1 and R 2 each independently represents an alkyl group or an alkenyl group having 9 to 29 carbon atoms)

  Α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine can be produced and used by the above method, but diα, ε-bis (γ-N- (carbon number). 10-30) Acylglutamyl) lysine already exists in the market, and such a commercial product can be purchased and used. As such a commercially available product, “Perisea L-30” (manufactured by Asahi Kasei Corporation; α, ε-bis (γ-N-lauroylglutamyl) lysine) can be preferably exemplified. The α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine thus obtained has the property of easily forming a bilayer, and the skin barrier tissue in which this action is damaged. To help rebuild. In order to exert such action, the skin external preparation is used in a total amount of one or more selected from α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine. It is preferable to contain 0.005% by mass, more preferably 0.01% by mass, and 10% by mass as the upper limit, and more preferably 1% by mass with respect to the total amount. This is because if the amount is too large, the effect reaches a peak, and there are cases in which the degree of freedom of prescription is restricted by a person, and if the amount is too small, the effect may not be achieved.

(2) L-carnitine which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing L-carnitine and / or a salt thereof as an essential component. L-carnitine has the structure shown below and has already been used as a raw material for cosmetics. Such a commercial product can be purchased and used. Moreover, since it is marketed also as a reagent, the acquisition is easy. In the present invention, such L-carnitine can be used as it is, or it can be contained in the form of a salt without any acid or the like. In storage, the salt state is more stable, so it is preferable to use a salt. As the salt, any salt that is usually used in an external preparation for skin can be used without particular limitation. For example, salts such as sulfates, hydrochlorides, nitrates, phosphates, carbonates, etc. Preferred examples include organic acid salts such as acid salts, tartrate salts, oxalate salts, lactate salts and acetate salts, and acidic amino acid salts such as glutamate salts and aspartates. This component, together with the component, has an action of rapidly regenerating and reconstructing damaged skin barrier tissue. At the same time, it also has an action of suppressing inflammation caused by a decrease in skin barrier function. In order to exert such an action, L-carnitine and / or a salt thereof may be contained in an amount of 0.1 to 10% by mass with respect to the total amount of the external preparation for skin, in terms of L-carnitine equivalent. Preferably, the content is 0.5 to 5% by mass. This is because if the amount is too small, the above effect may not be achieved, and if the amount is too large, the emulsification system may be damaged.

Ｌ−カルニチン

L-carnitine

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. In the external preparation for skin of the present invention, a water-in-oil emulsifier form is preferred. This is because the complementary action of the skin barrier function is improved by increasing the skin occlusiveness. In particular, the water-in-oil emulsifier form having a high internal phase is preferable because it does not impair this effect and has good usability such as a feeling of use. Here, the high internal phase water-in-oil emulsifier form means that the sum of the mass of water, the mass of ethanol, and the mass of polyhydric alcohol exceeds 50 mass%. In order to take such a high internal phase water-in-oil emulsifier form, it is preferable to emulsify using an organically modified clay mineral.

  Here, organic modification means that a part or all of the properties of an organic compound is made into a clay mineral by causing a part of the organic compound to form a strong or loose bond via a covalent bond or an ionic bond. This means that it is imparted to minerals. Examples of such modifications include a method of binding a quaternary amine group and an anion portion of a clay mineral, and a method of binding a carboxyl group and a cation portion of a clay mineral. A method of bonding the group and the anion portion of the clay mineral is particularly preferable.

  Although it does not necessarily limit as a compound which has a quaternary amino group which modifies a clay mineral, The compound called quaternium is illustrated. Quotanium is a low molecular weight substituted quaternary ammonium salt, and is preferably a cosmetic raw material registered in International Standard Cosmetic Ingredients (INCI). Furthermore, the compound having a quaternary amino group that modifies the clay mineral is preferably a quaternium compound contained in a conventional external skin preparation among quaternium compounds. Preferred examples of the quaternium compound used in conventional external preparations for skin include stearyl trimethyl ammonium chloride and dimethyl distearyl ammonium chloride. Stearyl trimethyl ammonium chloride, dimethyl distearyl ammonium chloride and the like are preferable because they can form a stable water-in-oil emulsion structure together with clay minerals.

  On the other hand, as a clay mineral (unmodified clay mineral) modified with a compound having a quaternary amino group, any clay mineral contained in a conventional skin external preparation can be used without any particular limitation. Preferred clay minerals contained in conventional skin external preparations include smectite-type hectorite, bentonite and montmorillonite; kaolinite; illite; marine clay mineral (sea mud); desert rose clay mineral; Among these, bentonite, hectorite, montmorillonite or kaolinite which can stabilize the water-in-oil emulsion structure is preferably exemplified.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersant is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by taking such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Or the modified clay mineral in this invention can also be obtained by removing a dispersing agent by concentrating under reduced pressure without filtering a dispersoid, and making it dry. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

  The modified clay mineral in the present invention can be prepared and used as described above, but a commercially available one can also be used. Some modified clay minerals on the market are used as external preparations for skin such as cosmetics. Preferable examples of commercially available modified clay minerals include dimethyl distearyl ammonium modified hectorite sold under the name “Benton 38V” by Elementis.

  In the skin external preparation of this invention, this component is contained preferably 0.5-10 mass%, More preferably, 1-5 mass% is contained. Such an ingredient acts as an emulsifier in the above-mentioned content range to form a high internal phase water-in-oil emulsifier form.

  Further, as described above, when taking the water-in-oil emulsifier form, it is preferable to contain silicone in order to compensate for the drawbacks of the feeling of use and finish of the water-in-oil emulsifier form. Is preferably contained in an amount of 10 to 35% by mass, more preferably 20 to 30% by mass. Among these, dimethicone or cyclomethicone is preferably 10 to 30% by mass, and more preferably 15 to 25% by mass. In particular, the mass of cyclomethicone is preferably 50% or more with respect to the sum of the masses of dimethicone and cyclomethicone. Examples of silicones other than dimethicone and cyclomethicone are polyether-modified methyl polysiloxanes such as POE-modified methyl polysiloxane, POP-modified methyl polysiloxane, and POP / POE-modified methyl polysiloxane, which may contain such components. This is preferable because the water-in-oil emulsion system can be stabilized. The preferable content of such polyether-modified methylpolysiloxane is more preferably 0.5 to 5% by mass and 1 to 3% by mass.

  The external preparation for skin of the present invention should be applied to a person with a reduced skin barrier function by utilizing the regeneration effect of the skin barrier function, and is intended to improve the reduced skin barrier function as a result of application. is there. Therefore, it is preferable to contain a component that is preferably administered when the skin barrier is lowered. As such a component, for example, a polyhydric alcohol can be preferably exemplified. Among polyhydric alcohols, those having high water retention, those having high biocompatibility, and those having high antibacterial activity can be suitably exemplified. Specifically, glycerin, 1,2-pentanediol, 1,2- One or more selected from hexanediol and diglycerin can be suitably exemplified. The preferable content of such components is 5 to 30% by mass, and more preferably 10 to 25% by mass. In particular, the content of glycerin is preferably 10 to 25% by mass, and more preferably 15 to 20% by mass. Such a form is preferable because a skin barrier function-complementing layer can be constructed on the skin having a reduced skin barrier function. Further, it is preferable to contain a polymer or copolymer having a component that protects skin from irritation, for example, methacryloyloxyethyl phosphorylcholine as a constituent monomer. Such polymers or copolymers already exist on the market, and such commercially available products can be purchased and used. Examples of commercially available products include “Lipidure HM” (manufactured by Nippon Oil & Fats Co., Ltd.) which is polymethacryloyloxyethyl phosphorylcholine, “Lipidure PMB” (manufactured by Nippon Oil & Fats Co., Ltd.) which is a methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer. “Lipidure NR” (manufactured by NOF Corporation), which is a methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymer, can be suitably exemplified. The total content of such components is 0.01 to 5% by mass, and more preferably 0.05 to 1% by mass, based on the total amount of the external preparation for skin.

  In addition to the above-mentioned components, the external preparation for skin of the present invention can contain optional components that are usually used in external preparations for skin. The external preparation for skin of the present invention can contain, in addition to such components, optional components that are usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oil such as beeswax, canola wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside; polyethylene glycol, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, Polyhydric alcohols such as propylene glycol, isoprene glycol, 2,4-hexanediol and 1,2-octanediol; moisturizing components such as sodium pyrrolidonecarboxylate, lactic acid and sodium lactate; the surface may be treated, Mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate and other powders; surface may be treated, bengara, yellow iron oxide, black Inorganic pigments of iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface treated pearlescent agents such as titanium mica, fish phosphorus foil, bismuth oxychloride; raked Red 202, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red Organic dyes such as 230, red 223, orange 201, red 213, yellow 204, yellow 203, blue 1, green 201, purple 201, red 204; polyethylene powder, polymethacrylic acid Organic powders such as methyl, nylon powder, organopolysiloxane elastomer; paraaminobenzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers Agents; sugar-based ultraviolet absorbers; ultraviolet absorbers such as 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole and 4-methoxy-4′-t-butyldibenzoylmethane; ethanol, isopropanol Lower alcohols such as vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripal Vitamin Bs such as Tate, Vitamin B6 dioctanoate, Vitamin B2 or derivatives thereof, Vitamin B12, Vitamin B15 or derivatives thereof; Vitamin Es such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, Vitamin D Preferred examples include vitamins such as vitamin H, pantothenic acid, pantethine and pyrroloquinoline quinone; and antibacterial agents such as phenoxyethanol. The external preparation for skin of the present invention can be produced by treating these components according to a conventional method.

  The external preparation for skin of the present invention can be produced by treating these components according to a conventional method. The external preparation for skin of the present invention is not particularly limited as long as it is externally applied to the skin. For example, basic cosmetics such as lotions, essences, emulsions, creams, packs, foundations, under-makeups, Makeup cosmetics such as control colors, highlights, UV protective cosmetics such as sun care milk and sun care cream, cleaning products such as rinses, shampoos, body shampoos, cosmetics for hair such as hair creams and hair packs, antifungals Skin external medicines, anti-inflammatory skin external medicines, steroid skin external medicines, external skin disinfectants, skin external goods, and the like can be suitably exemplified, among which cosmetics are preferable, and basic cosmetics are particularly preferable.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  In accordance with the formulation shown below, a cosmetic preparation in the form of a water-in-oil emulsifier (a form in which a microemulsion exists in water droplets), which is an external preparation for skin of the present invention, was produced. That is, the components of a and b are heated to 80 ° C., and k is kneaded to form a gel. C is added and dissolved therein, and the mixture is gradually added with emulsification and stirring. Upon cooling, a cosmetic 1 in the form of a water-in-oil emulsifier was obtained. In the same manner, Comparative Example 1 in which L-carnitine chloride was replaced with water and Comparative Example 2 in which “Perisea L-30” and a 0.1% sodium hydroxide aqueous solution were replaced with water were also prepared.

<Test Example 1>
Four parts of 2 cm × 4 cm were provided in the inner forearm of five volunteer panelists, and each part was stripped 15 times with surgical tape to create a skin barrier function lowering model. 50 mg of cosmetic 1 was applied to 1 part, 50 mg of the cosmetic of Comparative Example 1 was applied to 1 part, and 50 mg of the cosmetic of Comparative Example 2 was applied to 1 part, and the remaining 1 part was untreated as a control. One hour after the treatment, the cosmetic was removed by washing with water, allowed to stand for 10 minutes, and when equilibrium was reached, transcutaneously dissipated water (TEWL) was measured using a tevameter (manufactured by Integral). The results are shown in Table 2. From this, it can be seen that the skin barrier function is restored by the interaction between L-carnitine chloride and “Perisea L-30”.

  In the same manner as for cosmetic 1, cosmetics 2 to 4 in the form of a water-in-oil emulsifier, which are external preparations for skin of the present invention, were produced according to Table 3 below. Table 4 shows the results of evaluation using the same procedure as in Test Example 1. From this, it can be seen that the present invention preferably contains a polymer or copolymer containing methacryloyloxyethyl phosphorylcholine as a monomer.

  Similarly to cosmetic 1, cosmetic 5 in the form of a water-in-oil emulsifier, which is an external preparation for skin of the present invention, was produced according to the formulation shown in Table 5 below. When this was evaluated by the procedure of Test Example 1, the TEWL was 34,5 ± 16.9.

  The present invention can be applied to an external preparation for skin such as cosmetics.

Claims (6)

1) α, ε-bis (γ-N- (C10-30) acylglutamyl) lysine and / or a salt thereof, and 2) L-carnitine and / or a salt thereof, Skin external preparation. The skin external preparation according to claim 1, wherein the acyl group having 10 to 30 carbon atoms is a lauroyl group. The external preparation for skin according to claim 1 or 2, wherein the L-carnitine and / or a salt thereof is L-carnitine chloride. The skin external preparation according to any one of claims 1 to 3, comprising one or more selected from polyhydric alcohols shown in the following group A.
(A) Glycerin, 1,2-pentanediol, 1,2-hexanediol, diglycerin The external preparation for skin according to claim 4, comprising 5 to 20% by mass of glycerin. The skin external preparation according to any one of claims 1 to 5, further comprising a polymer or copolymer containing methacryloyloxyethyl phosphorylcholine as a constituent monomer.