JP2007254308A5 - - Google Patents

Description

The present invention relates to a skin external preparation such as cosmetics, more particularly, it relates to skin external preparation in water emulsifier type oil.

On the other hand, L- carnitine and / or its salts are known as active ingredients for cosmetics having anti-inflammatory action and the like, technology to be contained in cosmetics that already known (e.g., Patent Document 4, Patent Document 5, refer to Patent Document 6), be formulated water-in-oil emulsifier forms do not have known, in water-in-oil emulsion of high internal phase with an organic modified clay mineral, stable oil solubility to the system It is not known at all that it has an effect of incorporating a sufficient amount of the active ingredient, especially, solid oil-soluble active ingredient.

In view of such a situation, the present inventors, in a high internal phase water-in-oil emulsion using an organically modified clay mineral, have a stable oil-soluble active ingredient in the system, especially a solid oil-soluble effective ingredient. As a result of earnest research efforts in search of a technique for incorporating a sufficient amount of ingredients, the presence of L-carnitine and / or a salt thereof increases the stability of the water-in-oil emulsion system, The inventors have found that the active ingredient can be stably included in the system and have completed the invention. That is, the present invention is as follows.
(1) A skin external preparation in the form of a water-in-oil emulsifier containing a solid oil-soluble active ingredient, which contains 1) an organically modified clay mineral, 2) L-carnitine and / or a salt thereof. An external preparation for skin.
(2) The external preparation for skin according to (1), comprising 15 to 30% by mass of dimethicone or cyclomethicone.
(3) The skin external preparation according to (1) or (2), further comprising 1 to 10% by mass of a polyether-modified methylpolysiloxane .

(1) Organically modified clay mineral which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing an organically modified clay mineral as an essential component. Here, organic modification means that a strong or loose bond is formed between a part of a clay mineral and a part of an organic compound via a covalent bond or an ionic bond, and a part or a part of the property of the organic compound. This means that all is imparted to the clay mineral, and examples of such modifications include a method of binding the quaternary amine group and the anion portion of the clay mineral, a method of binding the carboxyl group and the cation portion of the clay mineral, A method of combining a quaternary amine group and an anion portion of a clay mineral is particularly preferable.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersion medium is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by adopting such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Alternatively, the modified clay mineral in the present invention can be obtained by removing the dispersion medium by concentrating under reduced pressure without filtering the dispersoid and drying it. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

(2) L-carnitine which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing L-carnitine and / or a salt thereof as an essential component. L-carnitine has the structure shown below and has already been used as a raw material for cosmetics. Such a commercial product can be purchased and used. Moreover, its availability is easy because it is also commercially available as reagents. In the present invention, according L- carnitine to directly can be used, such as are both without and hydrochloric acid, can also contain such salts. In storage, the salt state is more stable, so it is preferable to use a salt. As the salt, any salt that is usually used in an external preparation for skin can be used without particular limitation. For example, salts such as sulfates, hydrochlorides, nitrates, phosphates, carbonates, etc. Preferred examples include organic acid salts such as acid salts, tartrate salts, oxalate salts, lactate salts and acetate salts, and acidic amino acid salts such as glutamate salts and aspartates. Such components have the effect of stabilizing the structure of the organically modified clay mineral and improving the ability to include oil-soluble active ingredients. In order to exert such an action, L-carnitine and / or a salt thereof may be contained in an amount of 0.1 to 10% by mass with respect to the total amount of the external preparation for skin, in terms of L-carnitine equivalent. Preferably, the content is 0.5 to 5% by mass. This is because if the amount is too small, the above effect may not be achieved, and if the amount is too large, the emulsification system may be damaged.

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. The external preparation for skin of the present invention, Ru water emulsifier-shaped der-in-oil. This is because the organically modified clay mineral, which is an essential component, is very suitable for producing a water-in-oil emulsifier type composition. In particular , a high internal phase water-in-oil emulsifier form is preferred. Here, the water-in-oil emulsifier type high internal phase, and the mass of water, and the mass of the ethanol, the sum of the mass of the polyhydric alcohol is one which obtain super 50 mass%. Moreover, as mentioned above, in order to compensate for the drawbacks of the feeling of use and finish of the water- in-oil emulsifier, it is preferable to contain silicone, and the silicone content is 10 to 35% by mass. Preferably, it is 20-30 mass% more preferably. Among these, dimethicone or cyclomethicone is preferably 10 to 30% by mass, and more preferably 15 to 25% by mass. In particular, the mass of cyclomethicone is preferably 50% or more with respect to the sum of the masses of dimethicone and cyclomethicone. Examples of silicones other than dimethicone and cyclomethicone include polyether-modified methyl polysiloxanes such as POE-modified methyl polysiloxane, POP-modified methyl polysiloxane, and POP / POE-modified methyl polysiloxane, which may contain such components. This is preferable because the water-in-oil emulsion system can be stabilized. The preferable content of such polyether-modified methylpolysiloxane is more preferably 0.5 to 5% by mass and 1 to 3% by mass.

The external preparation for skin of the present invention, by adopting the configuration described above, may contain the active ingredient stably solid form oil soluble in the system. Examples of such active ingredients include triterpenic acids such as ursolic acid, oleanolic acid, and betulinic acid, derivatives of alkyl esters, alkenyl esters, and aromatic esters of the above-mentioned triterpenic acids, sphingosines, ceramides, phytosterols, and phytosterols. Preferable examples include phytosterol glycosides such as glucoside. The phytosterol is a generic name for plant sterols, and the plant sterols include stigmasterol, campesterol, sitosterol, and the like, and these are collectively called phytosterols. As phytosterols, there are many cases where a sterol fraction containing a plurality of phytosterols is taken out from a plant body such as wheat germ and used, and a cosmetic raw material obtained by purifying only such a fraction is also commercially available, and the present invention is concerned. Commercial raw materials can be purchased and used. Examples of such commercially available raw materials include “phytosterol” sold by Okayasu Shoten Co., Ltd. The preferred content of active ingredient content of the oil-soluble such solid is from 0.05 to 0.5 wt%, respectively.

In addition to the components described above, the external preparation for skin of the present invention can contain optional components that are usually used in external preparations for skin . The optional components, such as this, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut Oil, hydrogenated oil, mole, hardened castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, oils, waxes; liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, Hydrocarbons such as petroleum jelly and microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride and laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, monostearate Porioki shea sorbitan, etc.), POE sorbitol fatty acid esters (POE- sorbit monolaurate), POE glycerol fatty acid Steal (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propyre Polyhydric alcohols such as glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidone carboxylate Moisturizing ingredients such as lactic acid and sodium lactate; powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc. whose surface may be treated Body, the surface may be treated, inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface may be treated, mica Pearl agents such as titanium, fish phosphorus foil, bismuth oxychloride; red 202 which may be raked, Red 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue 1 No., green 201, purple 201, red 204, etc .; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; para-aminobenzoic acid UV absorbers; anthranils Acid UV absorbers; salicylic acid UV absorbers ; cinnamic acid UV absorbers ; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; UV absorbers such as 4-methoxy-4'-t-butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol Vitamin A or a derivative thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or a derivative thereof, vitamin B such as vitamin B12, vitamin B15 or a derivative thereof; α-tocopherol, β -Vitamin E such as tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like; and antibacterial agents such as phenoxyethanol are preferred.

<Test Example 1>
Cosmetics 1, Comparative Example 1 and Comparative Example 2 were held at −10 ° C. for 24 hours, then heated to 5 ° C. over 24 hours, held at 5 ° C. for 24 hours, and up to −10 ° C. over 24 hours. Stored in a winter aging box, which is a periodic temperature change storage with one cycle of cooling operation, stored for 1 month, extended to a hemocytometer at 1 at 20 ° C, and observed 20 fields at 100x magnification. The number of insoluble solids was counted, and the average number per visual field was determined. In cosmetic 1, no precipitated solid was observed, but 5.6 in Comparative Example 1 and 9.1 in Comparative Example 2 were observed. From this, it can be seen that the cosmetic of the present invention is excellent in oil-soluble active ingredient retention effect.

Claims (3)

A skin external preparation in the form of a water-in-oil emulsifier containing a solid oil-soluble active ingredient, characterized by comprising 1) an organically modified clay mineral and 2) L-carnitine and / or a salt thereof. , Topical skin preparation. The external preparation for skin according to claim 1, comprising 15 to 30% by mass of dimethicone or cyclomethicone. Furthermore, 1-10 mass% of polyether modified methyl polysiloxane is contained, The skin external preparation of Claim 1 or 2 characterized by the above-mentioned.