JP2007308383A - Water-in-oil type emulsion type external preparation for skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means for improving long period stability at low temperature having freezing possibility in a water-in-oil type emulsion type. <P>SOLUTION: This emulsion type external preparation for the skins is characterized by comprising (1) carnitine and/or its salt and (2) a diglycerol monofatty acid ester and/or an N-acylglutamic acid diester. The emulsion type is preferably a water-in-oil type emulsion type, and the emulsion preferably contains an organic-modified clay mineral. In the oil phase, it is preferable that the sum of the content of cyclomethicone and the content of dimethicone having viscosity of ≤1 mPa s is preferably ≥50 mass% based on the total amount of the oil phase. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a skin external preparation, and more particularly, to a skin external preparation in the form of a water-in-oil emulsifier suitable for cosmetics. In the present invention, the water-in-oil emulsifier form is a general term for emulsifier forms in which an oil phase is present in the outermost phase, and includes a complex emulsifier form such as an oil-in-water emulsifier form in oil.

  The water-in-oil emulsion has an oily component in the continuous phase, and therefore has a higher moisturizing effect due to the blocking effect than the oil-in-water emulsion, and is excellent in transdermal absorbability of the oily active ingredient, or oily soil. It has various desirable properties such as being excellent in the action of dissolving and removing the cosmetics in cosmetics. On the other hand, as a feeling of use, it has an oily and heavy defect. As a method of overcoming these disadvantages and taking advantage of the advantages of water-in-oil emulsions, various attempts have been made to produce high-in-water water-in-oil emulsions, and organic modifications such as dimethyl distearyl ammonium chloride-modified hectorite. Techniques for producing high-in-water water-in-oil emulsions using clay minerals have been developed (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3). Further, as a high internal phase water-in-oil emulsifier form, for example, there are those utilizing a gel of diglycerin monooleate or triglycerin diisostearate and a polyhydric alcohol (see, for example, Patent Document 4). In such a high internal phase water-in-oil emulsifier form, storage of the internal aqueous phase occurs during storage for 3 months or more at a low freezing temperature such as −10 ° C. or less, resulting in emulsified particles. It was not uncommon for occasions to occur. Such emulsified particles also affect the usability such as the feeling of use, and in cosmetics with functionalities such as cleansing cosmetics, they can cause the functionality to be impaired. It can be said that development of means to do this is required.

  In addition, carnitine and / or a salt thereof is known as an active ingredient for cosmetics having an anti-inflammatory action and the like, and a technique to be included in cosmetics is already known (for example, Patent Document 5, Patent Document) 6, refer to Patent Document 7), and there is no known technique for combining carnitine and / or a salt thereof with diglycerin monofatty acid ester and / or N-acylglutamic acid diester into an external emulsifier type skin preparation. In addition, it has not been known at all that the external preparation for skin having such a combination of ingredients can maintain a good emulsified state when stored at -10 ° C. or lower for 3 months or longer.

JP 2005-255623 A JP 2004-292373 A JP 2001-58937 A JP 09-249547 A JP 2005-53835 A JP 2004-339144 A JP 2004-242509 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide means for improving long-term stability at a low temperature with a possibility of freezing in a water-in-oil emulsifier form.

In light of such circumstances, the present inventors have sought to find a means for improving long-term stability at low temperatures that can be frozen in a water-in-oil emulsifier form, and as a result of intensive research efforts , Found that an emulsifier-type skin external preparation containing carnitine and / or a salt thereof in combination with diglycerin monofatty acid ester and / or N-acylglutamic acid diester has such characteristics, It came to complete. That is, the present invention is as follows.
(1) A skin external preparation in the form of an emulsifier, comprising 1) carnitine and / or a salt thereof, and 2) a diglycerin monofatty acid ester and / or an N-acylglutamic acid diester.
(2) The external preparation for skin according to (1), wherein the emulsifier form is a water-in-oil emulsifier form.
(3) The skin external preparation according to (1) or (2), which contains an organically modified clay mineral as an emulsifier.
(4) In the oil phase, the sum of the contents of cyclomethicone and dimethicone having a viscosity of 1 mPa · s or less is 50% by mass or more based on the total amount of the oil phase, (1) to (3) The skin external preparation of Claim 1.

  According to the present invention, in the water-in-oil emulsifier form, a means for improving long-term stability at a low temperature that can be frozen can be provided.

(1) Carnitine which is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention contains carnitine and / or a salt thereof as a preferable component as an essential component. As carnitine, L-carnitine is preferable, and L-carnitine has the structure shown below, and has already been used as a raw material for cosmetics. Of course, D-carnitine and a racemate can also be used. In the present invention, commercially available products that have already been sold can be purchased and used. Moreover, since it is marketed also as a reagent, the acquisition is easy. In the present invention, such L-carnitine can be used as it is, or it can be contained in the form of a salt without any acid or the like. In storage, the salt state is more stable, so it is preferable to use a salt. As the salt, any salt that is usually used in an external preparation for skin can be used without particular limitation. For example, salts such as sulfates, hydrochlorides, nitrates, phosphates, carbonates, etc. Preferred examples include organic acid salts such as acid salts, tartrate salts, oxalate salts, lactate salts and acetate salts, and acidic amino acid salts such as glutamate salts and aspartates. Such an ingredient works together with diglycerin monofatty acid ester and / or N-acylglutamic acid diester described later in skin external preparation in the form of a water-in-oil emulsifier to improve long-term stability at a low temperature that may be frozen. Has an effect. In order to exert such an action, L-carnitine and / or a salt thereof may be contained in an amount of 0.1 to 10% by mass with respect to the total amount of the external preparation for skin, in terms of L-carnitine equivalent. Preferably, the content is 0.5 to 5% by mass. This is because if the amount is too small, the above effect may not be achieved, and if the amount is too large, the emulsification system may be damaged.

Ｌ−カルニチン

L-carnitine

(2) Diglycerin monofatty acid ester and N-acyl glutamic acid diester which are essential components of the skin external preparation of the present invention The skin external preparation of the present invention comprises diglycerin mono fatty acid ester and / or N-acyl glutamic acid diester as an essential component. It is characterized by containing. The fatty acid residue of the diglycerin monofatty acid ester can be used without particular limitation as long as it is a fatty acid residue used in cosmetics, for example, 2-ethylhexanoic acid residue, lauric acid residue. Preferred examples include groups, myristic acid residues, palmitic acid residues, stearic acid residues, behenic acid residues, oleic acid residues, linoleic acid residues, linolenic acid residues, and isostearic acid residues. Particularly preferred are oleic acid residues or isostearic acid residues. Moreover, as N-acyl glutamic acid diester, a lauroyl group, a palmitoyl group, a stearoyl group, an oleoyl group etc. can be illustrated preferably as an acyl group, A lauroyl group is especially preferable. Preferable examples of the ester include phytosteryl ester, octyldodecyl ester, and behenyl ester. Specific examples of the compound include N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl). / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) and the like can be preferably exemplified, and N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl) can be particularly suitably exemplified. Such an N-acylated glutamic acid diester is obtained by condensing glutamic acid and acyl chloride in the presence of an alkali to form N-acyl glutamic acid, and then in the presence of a base or acid, optionally in the presence of a solvent, and dehydrating with the corresponding alcohol. It can be produced by condensation. N-acylated glutamic acid diesters can be synthesized in this way, but some are already commercially available as cosmetic raw materials, and such commercial products can be purchased and used. . Particularly preferred commercially available products are “El Deu PS203” (N-lauroyl-L-glutamate di (phytosteryl / octyldecyl)) and “El Deu CL-301” (N-lauroyl glutamate di (cholesteryl / Behenyl / octyldodecyl)), “Elduu Cl-202” (N-lauroylglutamate di (cholesteryl / octyldodecyl)), “Elduu PS-304” (N-lauroylglutamate di (phytosteryl / behenyl / octyldodecyl)), etc. Among them, “El Dew PS203” is particularly preferable. These diglycerin monofatty acid esters and N-acyl glutamic acid diesters can contain only one species, or two or more species can be contained in combination. Such an ingredient works with the carnitine and / or a salt thereof, and has an action of improving long-term stability at a low temperature that may be frozen in a water-in-oil emulsifier type skin external preparation. In order to exert such an action, it is preferable to contain 0.05 to 5% by mass of one or more selected from such components with respect to the total amount of the external preparation for skin. It is particularly preferable to contain ˜1% by mass.

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. The external skin preparation of the present invention can be used without particular limitation as long as it is applied externally to the skin, for example, cosmetics, skin external medicine, skin external goods and the like can be suitably exemplified, It is particularly preferable to apply to cosmetics. This is because the external preparation for skin of the present invention has an unparalleled feeling of use and is particularly suitable for cosmetics where the feeling of use is important. The cosmetics are not particularly limited as long as the water-in-oil emulsifier form can be applied. For example, basic cosmetics such as essences, emulsions, creams, under-makeups, foundations, cheek colors, mascaras, eyeliners. Suitable examples include makeup cosmetics such as hair cosmetics such as hair cream.

  In the external preparation for skin of the present invention, it is preferable to contain an emulsifier for forming a water-in-oil emulsifier form in addition to the essential components, and as the emulsifier, an organically modified clay mineral or diglycerin monooleate is preferable. Preferable examples include triglycerin diisostearate and the like. In the case of using diglycerin monooleate as an emulsifier, the amount for emulsification is added to the amount as an essential component, and the role for stabilization and the role for emulsification may be combined. it can.

  In the organically modified clay mineral, organically modified means that a part of the organic compound is bonded to a part of the clay mineral to form a strong or loose bond through a covalent bond or an ionic bond. This means that some or all of the mineral is imparted to the clay mineral. Examples of such modifications include a method of bonding a quaternary amine group and an anion portion of the clay mineral, a method of bonding a carboxyl group and a cation portion of the clay mineral, etc. And a method of binding a quaternary amine group and an anion portion of a clay mineral is particularly preferable.

  Although it does not necessarily limit as a compound which has a quaternary amino group which modifies a clay mineral, The compound called quaternium is illustrated. Quotanium is a low molecular weight substituted quaternary ammonium salt, and is preferably a cosmetic raw material registered in International Standard Cosmetic Ingredients (INCI). Furthermore, the compound having a quaternary amino group that modifies the clay mineral is preferably a quaternium compound contained in a conventional external skin preparation among quaternium compounds. Preferred examples of the quaternium compound used in conventional external preparations for skin include stearyl trimethyl ammonium chloride and dimethyl distearyl ammonium chloride. Stearyl trimethyl ammonium chloride, dimethyl distearyl ammonium chloride and the like are preferable because they can form a stable water-in-oil emulsion structure together with clay minerals.

  On the other hand, as a clay mineral (unmodified clay mineral) modified with a compound having a quaternary amino group, any clay mineral contained in a conventional skin external preparation can be used without any particular limitation. Preferred clay minerals contained in conventional skin external preparations include smectite-type hectorite, bentonite and montmorillonite; kaolinite; illite; marine clay mineral (sea mud); desert rose clay mineral; Among these, bentonite, hectorite, montmorillonite or kaolinite which can stabilize the water-in-oil emulsion structure is preferably exemplified.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersant is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by taking such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Or the modified clay mineral in this invention can also be obtained by removing a dispersing agent by concentrating under reduced pressure without filtering a dispersoid, and making it dry. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

  The modified clay mineral in the present invention can be prepared and used as described above, but a commercially available one can also be used. Some modified clay minerals on the market are used as external preparations for skin such as cosmetics. Preferable examples of commercially available modified clay minerals include dimethyl distearyl ammonium modified hectorite sold under the name “Benton 38V” by Elementis.

  In the skin external preparation of this invention, this component is contained preferably 0.5-10 mass%, More preferably, 1-5 mass% is contained. Such an ingredient acts as an emulsifier in the above-mentioned content range to form a high internal phase water-in-oil emulsifier form.

  When diglycerin monooleate and / or triglycerin diisostearate is contained as an emulsifier, 0.5 to 2 times the mass of the emulsifier may be included together with a polyhydric alcohol such as maltitol or sorbitol. preferable. “Nikkor DGMO-C” (manufactured by Nippon Surfactant Co., Ltd.) can be preferably exemplified as a raw material for cosmetics of diglycerin monooleate, and “Emerest” can be used as a raw material for cosmetics of triglycerin diisostearate. “2452” (manufactured by Emery Co., Ltd.) can be preferably exemplified. The preferable content of this component is 1 to 10% by mass, more preferably 2 to 7% by mass, based on the total amount of the external preparation for skin. This is because if the amount is out of the range, emulsification may not be possible or stability may be impaired.

  In the external preparation for skin of the present invention, in addition to the essential components, oily components, components that are difficult to dissolve both aqueous components, especially non-polar components such as silicones such as dimethicone and hydrocarbons such as liquid paraffin Examples of the component that preferably contains an insoluble component and is difficult to dissolve include phytosterol glycosides, glycosphingolipids, ursolic acid, ursolic acid esters, and salts thereof. Such an ingredient is an active ingredient having preferable functions such as a photoaging prevention effect, a turnover adjusting effect, a moisturizing effect on the skin, and the phytosterol is a general term for plant sterols, and is a plant sterol. There are stigmasteranol, campesterol, sitosterol and the like, and these are collectively referred to as phytosterol. A phytosterol glycoside is obtained by binding a sugar chain to this phytosterol. As the phytosterol glycoside, a sterol glycoside fraction containing a plurality of phytosterol glycosides is taken out from a plant such as wheat germ. In many cases, cosmetic raw materials obtained by purifying only such fractions are also commercially available, and such commercial raw materials of the present invention can be purchased and used. Usually, such components often contain glycosphingolipids extracted at the same time. Examples of such commercially available materials include “Phytosteside” sold by Okayasu Shoten Co., Ltd. About 85% by mass of such “phytosteside” is a glycoside of phytosterol, and about 15% by mass is a glycosphingolipid. Ursolic acid is a triterpenic acid contained in plants such as rosemary, and this ester can be obtained by condensing acid chloride derived from ursolic acid with the corresponding alcohol in the presence of alkali. Preferred examples include ursolic acid ethyl ester, ursolic acid stearyl ester, ursolic acid oleyl ester, ursolic acid benzyl ester, ursolic acid phenethyl ester and the like. Particularly preferred is ursolic acid benzyl ester. The preferable content of such an insoluble active ingredient, especially a solid component, is 0.05 to 0.5% by mass.

  Since the external preparation for skin of the present invention takes the form of a water-in-oil emulsifier, in order to compensate for the drawbacks of the feeling of use and finish of the water-in-oil emulsifier, silicone, particularly preferably cyclomethicone and / or a viscosity of 1 mPa · s. The following dimethicone is preferably contained, and the silicone content is preferably 10 to 50% by mass, more preferably 20 to 40% by mass, based on the total amount of the cosmetic. The sum of the contents of methicone and dimethicone having a viscosity of 1 mPa · s or less is preferably 50% by mass or more, more preferably 55% by mass or more based on the total amount of the oil phase.

  Moreover, in the skin external preparation of this invention, when using the said organic modified clay mineral as an emulsifier, in the meaning which assists the emulsification effect | action of the said organic modified clay mineral, POE modified methylpolysiloxane, POP modified methylpolysiloxane, POP · POE A suitable example is the inclusion of a polyether-modified methylpolysiloxane such as a modified methylpolysiloxane. The preferable content of such polyether-modified methylpolysiloxane is more preferably 0.5 to 5% by mass and 1 to 3% by mass.

  When the organically modified clay mineral is used as an emulsifier, a preferable optional component other than the above components is exemplified by a polyhydric alcohol that can stabilize the emulsified state. Particularly preferred are glycerin, diglycerin and dipropylene glycol. Such a component may contain only one species or may contain two or more species in combination. A preferable content is 5-30 mass% with respect to the total amount of skin external preparations in total, More preferably, it is 10-25 mass%. In addition, the addition of 3 to 7% by mass of one or more selected from 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol also improves antiseptic power. From the viewpoint of making it.

  In addition to the above, the external preparation for skin of the present invention may contain any commonly used optional component as long as the effects of the present invention are not impaired. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oil such as beeswax, canola wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Oil agents such as synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; fatty acid soap (sodium laurate) Anionic surfactants such as potassium lauryl sulfate, alkyl sulfate triethanolamine ether; cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric Amphoterics such as surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), acylmethyl taurine, etc. Surfactants: sorbitan fatty acid esters (such as sorbitan monostearate and sorbitan sesquioleate), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (monostearic acid) Propylene glycol, etc.), hydrogenated castor oil derivative, glycerin alkyl ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.) POE glycerol fatty acid esters (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetro Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; polyethylene glycol, glycerin, erythritol, sorbitol, xylitol Polyhydric alcohols such as maltitol, propylene glycol, and 2,4-hexanediol; moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, and sodium lactate; surface-treated mica, talc, kaolin, Powders such as synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate; surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, Inorganic pigments of ultramarine, bitumen, titanium oxide and zinc oxide; table Pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, which may be treated; red 202, red 228, red 226, yellow 4 and blue 404 which may be raked Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc. Organic pigments: Organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomers; paraaminobenzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; -Based ultraviolet absorbers; benzophenone-based ultraviolet absorbers; sugar-based ultraviolet absorbers; 2- (2'-hydroxy-5'-t-octylphenyl) ben UV absorbers such as triazole and 4-methoxy-4'-t-butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 Vitamin B such as dioctanoate, vitamin B2 or derivatives thereof, vitamin B12, vitamin B15 or derivatives thereof; vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, Preferable examples include vitamins such as pantothenic acid, panthetin and pyrroloquinoline quinone; and antibacterial agents such as phenoxyethanol.

  The skin external preparation of this invention can manufacture the skin external preparation of this invention by processing the above-mentioned component in accordance with a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

  A cosmetic in the form of a water-in-oil emulsifier, which is an external preparation for skin of the present invention, was produced according to the formulation shown below. That is, the components of a and b are heated to 80 ° C., and k is kneaded to form a gel. C is added and dissolved therein, and the mixture is gradually added with emulsification and stirring. Upon cooling, a cosmetic 1 in the form of a water-in-oil emulsifier was obtained. In the same manner, Comparative Example 1 in which L-carnitine chloride was replaced with water and Comparative Example 2 in which “L-Du PS203” was replaced with dimethicone were also prepared.

<Test Example 1>
For cosmetic 1, Comparative Example 1 and Comparative Example 2, the low-temperature storage stability was examined by the following operation. That is, a sample stored at −10 ° C. for 4 months is stored at 20 ° C. for 24 hours, and after returning the temperature to 20 ° C., it is filled into a cylindrical dish made of a transparent acrylic resin having an inner diameter of 5 cmφ and a height of 1 cm, Light was radiated from above 30 ° C. to illuminate the plane formed by the composition at the top of the dish, and the uneven structure on the surface was converted into a shadow. This was photographed with a digital camera from above 90 ° C. and used as image data. Image data was taken into a personal computer, binarized using 50% of the maximum luminance as a threshold, and the concave and convex portions were converted into black dots. The number of bright spots of the black dots was divided by the total number of bright spots and multiplied by 100 to obtain the unevenness ratio (%). The unevenness ratio is shown in Table 2. From this, it can be seen that the external preparation for skin of the present invention has little unevenness even under storage conditions of -10 ° C for 4 months, and is not emulsified.

  In the same manner as in Example 1, cosmetics 2 to 5 which are external preparations for skin of the present invention were prepared according to the following formulation. When evaluation was performed according to the procedure of Test Example 1, the results shown in Table 4 were obtained. From this, it can be seen that the same effect as the cosmetic 1 is achieved.

  According to the formulation shown below, cosmetic 6 which is an external preparation for skin of the present invention was produced. That is, knead the component (a), dilute the component (b) and dilute it, adjust the temperature to 80 ° C., and gradually add emulsified in advance to 80 ° C. with stirring to emulsify, The mixture was cooled with stirring to obtain a water-in-oil emulsifier type cosmetic 6. Comparative Example 3 in which L-carnitine chloride in cosmetic 6 was replaced with water and Comparative Example 4 in which diglyceryl monooleate was replaced with “silicone KF6017” were also prepared in the same manner. Table 6 shows the evaluation results of the procedure of Test Example 1. From this, the same effect as in Examples 1 and 2 was also observed in this system.

  The present invention can be applied to an external preparation for skin such as cosmetics.

Claims (4)

1) Carnitine and / or its salt, 2) Diglycerin monofatty acid ester and / or N-acyl glutamic acid diester The skin external preparation according to claim 1, wherein the emulsifier form is a water-in-oil emulsifier form. The skin external preparation according to claim 1 or 2, characterized in that it contains an organically modified clay mineral as an emulsifier. 4. The oil phase according to claim 1, wherein the sum of the contents of cyclomethicone and dimethicone having a viscosity of 1 mPa · s or less is 50% by mass or more based on the total amount of the oil phase. Topical skin preparation.