JP4913487B2 - Cosmetics characterized by a feeling of use - Google Patents

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin in the form of an oil-in-water-in-oil emulsifier suitable for cosmetics.

The effect of cosmetics is to keep the skin clean and healthy according to the Pharmaceutical Affairs Law, and moisturizing ingredients, whitening ingredients, anti-inflammatory ingredients, etc. have been developed and formulated. However, the function of cosmetics is not limited to such a function, and it is also certain that there is a favorable effect induced by comfort by using the cosmetic. On the other hand, psychological conditions such as stress overload are also known to induce rough skin, and the use of cosmetics has a direct effect on the skin, It is considered that the relaxation in the psychological aspect is induced through the comfortable feeling of use, and thus the skin condition is also improved indirectly from the inner surface (for example, Patent Document 1, Patent Document). 2, Patent Document 3, Patent Document 4, Patent Document 5, Patent Document 6, and Patent Document 7). Furthermore, it is known that such an element that acts on a psychological aspect is not limited to a tactile stimulus such as a feeling of use but is also played by a visual stimulus (see, for example, Patent Document 8). As described above, it can be said that it is desired to adjust the tactile sensation to a preferable state in use in a skin external preparation administered to the skin which is a sensitive sensory organ such as cosmetics.

  Regarding the topical skin preparation, when considering the relationship with the formulation in terms of tactile stimulation, in the lotion dosage form, the friction resistance value in rubbing rapidly increases with the volatilization of the aqueous carrier as a solvent during use. Even if it is suitable as a dosage form of the active ingredient, a suitable tactile stimulation imparting dosage form has a point to be improved. Among the emulsifier forms, the oil-in-water emulsifier form reverses to the water-in-oil emulsifier form along with volatilization of the aqueous component in the external phase in the process of applying and rubbing on the skin. However, there are disadvantages such as being too light and not comfortable, and this dosage form also has a point to be improved. In the water-in-oil emulsifier form, there is a merit that the friction coefficient does not rise rapidly due to reversal, but because the spread itself is very heavy and there are drawbacks such as feeling greasy after application, this dosage form also has It has points to be improved. In the case of simple oil systems, although there is a feeling of rubbing without a feeling of friction during use, excessive oil remains on the skin after use, and there are disadvantages such as being unsuitable as a dosage form of an aqueous active ingredient. This dosage form also has a point to be improved. That is, it can be said that there is a demand for development of a dosage form that has a basic direct action as an external preparation for skin and has an enhanced indirect action in use feeling.

  Organically modified clay minerals such as dimethyl distearyl ammonium-modified hectorite form a gel with an oily component and have the property of incorporating water into the gel, and this property is used as an emulsifying component ( For example, see Patent Document 9 and Patent Document 10.) Further, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl) It is known that acylated glutamic acid diesters such as N-lauroyl-L-glutamic acid di (phytosteryl / octyldodecyl) are blended in cosmetics as oily amino acid derivatives useful as carriers for sparingly soluble active ingredients ( For example, see Patent Document 11). Furthermore, a technique for incorporating an acylated glutamic acid diester into a water-in-oil emulsifier form is already known (see, for example, Patent Document 12 and Patent Document 13). However, a skin external preparation in the form of an oil-in-water-in-oil emulsifier containing 1) an organically modified clay mineral and 2) an N-acyl (10 to 30 carbon atoms) dialkyl glutamate (1 to 30 carbon atoms) ester is known. In addition, it is not known at all that it is possible to obtain a skin external preparation having a feeling of use that induces tactile stimulation suitable for stress relaxation at the time of use by adopting such a configuration.

JP 2001-233723 A JP 2001-233731 A JP 2000-178128 A JP 2005-253883 A JP 2005-179221 A Japanese Patent Laid-Open No. 11-341993 WO01 / 098442 JP 2000-189242 A JP-A-11-76799 JP-A-10-194924 JP 2005-206573 A JP 05-279238 A Japanese Patent Laid-Open No. 06-1555055

  The present invention has been made under such circumstances, and an object of the present invention is to provide a dosage form that is comfortable in use feeling.

In view of such circumstances, the present inventors have found that heart stabilizes and suitable stress relaxation in its feeling, seeking pleasant dosage form, the results of extensive research efforts, 1) Organic-modified clay Oil containing mineral, 2) polyether-modified methylpolysiloxane, 3) N-acyl (C10-30) dialkyl glutamate (C1-30) ester, and 4) specific moisturizing polymer It has been found that a skin external preparation in the form of an oil-in-water emulsifier has such characteristics, and has completed the invention. That is, the present invention is as follows.
(1) A skin external preparation in the form of an oil-in-water oil-in-oil emulsifier, comprising: 1) an organically modified clay mineral, 2) a polyether-modified methylpolysiloxane, 3 ) N-acyl (10 to 10 carbon atoms) 30) containing a dialkyl glutamate (1-30 carbon atoms) ester, and containing a moisturizing polymer selected from 4) polymethacryloyllysine, polyglucosylethyl methacrylate and polymethacryloyloxyethyl phosphorylcholine in the aqueous phase. and wherein, skin Hadagaiyo agent.
(2) The N-acyl (10 to 30 carbon atoms) dialkyl glutamic acid (1 to 30 carbon atoms) ester is N-lauroyl glutamate di (phytosteryl / octyldodecyl), described in (1) Topical skin preparation.
(3), wherein the polyether portion constituting the port Rieteru modified methylpolysiloxane is a polyethylene glycol, a skin external preparation as described in (1) or (2).

  According to the present invention, it is possible to provide a dosage form that is comfortable to use.

(1) Organically modified clay mineral which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing an organically modified clay mineral as an essential component. Here, organic modification means that a part or all of the properties of an organic compound is made into a clay mineral by causing a part of the organic compound to form a strong or loose bond via a covalent bond or an ionic bond. This means that it is imparted to minerals. Examples of such modifications include a method of binding a quaternary amine group and an anion portion of a clay mineral, and a method of binding a carboxyl group and a cation portion of a clay mineral. A method of combining the group and the anion portion of the clay mineral is particularly preferable.

Although it does not necessarily limit as a compound which has a quaternary amino group which modifies a clay mineral, The compound called quaternium is illustrated. Quotanium is a low molecular weight substituted quaternary ammonium salt, and is preferably a cosmetic raw material registered in International Standard Cosmetic Ingredients (INCI). Furthermore, the compound having a quaternary amino group that modifies the clay mineral is preferably a quaternium compound contained in a conventional external skin preparation among quaternium compounds. Preferred examples of the quaternium compound used in conventional external preparations for skin include stearyl trimethyl ammonium chloride and dimethyl distearyl ammonium chloride. Stearyl trimethyl ammonium chloride, dimethyl distearyl ammonium chloride, and the like are preferable because they can form a stable aqueous oil-in-water component emulsion structure together with clay minerals. In particular, when the aqueous component is an oil-in-water emulsion, an emulsion having a continuous phase as an oil phase can be formed without significantly affecting the oil-in-water emulsion. preferable.

  On the other hand, as a clay mineral (unmodified clay mineral) modified with a compound having a quaternary amino group, any clay mineral contained in a conventional external preparation for skin can be used without particular limitation. Preferred clay minerals contained in conventional skin external preparations include smectite-type hectorite, bentonite and montmorillonite; kaolinite; illite; marine clay mineral (sea mud); desert rose clay mineral; Among these, bentonite, hectorite, montmorillonite or kaolinite which can stabilize the water-in-oil emulsion structure is preferably exemplified.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersant is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by taking such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Or the modified clay mineral in this invention can also be obtained by removing a dispersing agent by concentrating under reduced pressure without filtering a dispersoid, and making it dry. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

  The modified clay mineral in the present invention can be prepared and used as described above, but a commercially available one can also be used. Some modified clay minerals on the market are used as external preparations for skin such as cosmetics. Preferable examples of commercially available modified clay minerals include dimethyl distearyl ammonium modified hectorite sold under the name “Benton 38V” by Elementis.

  In the skin external preparation of the present invention, such components are preferably contained in an amount of 0.5 to 10% by mass, more preferably 1 to 5% by mass. Such an ingredient works as an emulsifier within the above-mentioned range of contents, and at the same time, works together with N-acyl glutamic acid diester in the feeling of use at the time of application, making the applied person feel comfortable and relaxing. And has the effect of relieving stress. Thereby, the bad influence to the skin by stress can be reduced and relieved. In particular, by taking the oil-in-water emulsifier form in oil, the change in the friction coefficient that occurs several times due to the change in the system due to the volatilization of the volatilization component moderately stimulates the tactile sensation and enhances the relaxation effect.

(2) N-acyl glutamic acid diester which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is an N-acyl (10 to 30 carbon atoms) dialkyl glutamic acid (1 to 30 carbon atoms) ester as an essential component. Contained as. The acyl group constituting the component may be saturated or unsaturated, for example, 2-ethylhexanoyl group, lauroyl group, myristoyl group, palmitoyl group, stearoyl group, behenoyl group, oleoyl group, isostearoyl group, A linolenoyl group etc. can be illustrated suitably, A lauroyl group is especially preferable. In addition, the alkyl group constituting the dialkyl ester may be branched, straight chain, or cyclic, for example, octyl group, lauryl group, cetyl group, stearyl group, isostearyl group, behenyl group, octyldodecyl. Preferred examples include phytosteryl groups such as campesteryl group and sitosteryl group, and cholesteryl group. Specific examples of the compound include N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl). / Behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) and the like can be preferably exemplified, and N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl) can be particularly suitably exemplified. Such an N-acyl glutamic acid diester is obtained by condensing glutamic acid and acyl chloride in the presence of an alkali to form N-acyl glutamic acid, and then in the presence of a base or acid, optionally in the presence of a solvent, and dehydrating condensation with the corresponding alcohol. Can be manufactured. As the N-acylglutamic acid diester, those synthesized in this way can be used, but there are those already marketed as cosmetic raw materials, and such commercial products can be purchased and used. A particularly preferred commercially available product is “Erudu PS203” (N-lauroyl-L-glutamate di ( phytosteryl / octyldodecyl)) sold by Ajinomoto Co., Inc. These components can be contained alone or in combination of two or more. The preferred content is 0.1 to 10% by mass, more preferably 1 to 5% by mass, based on the total amount of the external preparation for skin. Such an ingredient has an appropriate effect on the system and has an effect of enhancing the feeling of adhesion between the finger and the skin at the time of spreading, and when used together with the above organically modified clay mineral, makes the applied person feel comfortable, It has the action of relaxing, stabilizing the mind and relieving stress. Thereby, the bad influence to the skin by stress can be reduced and relieved. In particular, in the oil-in-water oil-in-water emulsifier form, this effect is remarkable when this component is present in the oil phase (outermost phase).

(3) Skin external preparation of the present invention The skin external preparation of the present invention contains the essential components and the polyether-modified methylpolysiloxane described later in the outermost oil phase, and the moisturizing polymer described later in the aqueous phase. It is characterized by being in the form of an oil-in-water oil emulsifier. This is because such an oil-in-water-in-oil emulsified form can provide greater comfort in use. The external preparation for skin of the present invention is not particularly limited as long as it is externally administered to the skin, and examples thereof include cosmetics, external preparations for skin, and sundry items. Of these, cosmetics are particularly preferred. This is because the action of the external preparation for skin of the present invention is mild. The cosmetic is preferably a quasi-drug, and the quasi-drug preferably contains an anti-inflammatory component such as glycyrrhizinate or stearyl glycyrrhetinate as an active ingredient in an amount of 0.05 to 0.1% by mass. . In particular, since glycyrrhizinate has a surface active action, it is preferable to contain it as a surfactant in an oil-in-water emulsion dispersed in an oil phase. As such an active ingredient having a surface-active action, there is a mulberry extract, a camellia extract, etc. containing a large amount of saponins, and it is also preferable to contain these for the same purpose. Preferable content of such a component is 0.05 to 0.1% by mass. This is because the combination of essential components of the present invention has a low effect of suppressing inflammation itself. In the preparation for external use of the skin of the present invention, it is associated with the effect that the usage mode is strictly observed. Therefore, in order to comply with the usage mode, a cosmetic that imparts a sense of stability to the mind through its usage feeling. It is preferable to have an indication to the effect.

In the external preparation for skin of the present invention, in addition to the essential components described above, optional components that are usually used in external preparations for skin such as cosmetics can be contained. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, oils such as beeswax, molasses, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax; , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Rokisan, linear polysiloxanes such as diphenyl polysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, cyclic polysiloxanes such as dodeca methylcyclohexane siloxane; amino-modified methylpolysiloxane, A alkyl-modified polysiloxane, fluorine-modified polysiloxane Oils such as silicone oil such as modified polysiloxane such as fatty acid soap (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkylsulfuric triethanolamine ether; stearyltrimethylammonium chloride, Cationic surfactants such as benzalkonium chloride and laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide) 1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan monostearate, sesquiskies) Sorbitan oleate, etc.), glycerin fatty acids (eg glyceryl monostearate), propylene glycol fatty acid esters (eg propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monoole) Acid, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin) Monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether, etc.), Pluronic type , POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl Nonionic surfactants such as glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol Polyhydric alcohols such as coal, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidonecarboxylate, lactic acid, lactic acid Moisturizing ingredients such as sodium; surface treated powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate ; surface May be treated, inorganic pigments of bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface may be treated, titanium mica, fish phosphorus foil Pearl agents such as bismuth oxychloride; red 202, red 228, red 226, yellow which may be raked Color No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple 201 No., organic dyes such as red No. 204; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; paraaminobenzoic acid UV absorber; anthranilic acid UV absorber; salicylic acid UV absorber; cinnamic acid UV absorber; benzophenone UV absorber; sugar UV absorber; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t UV absorbers such as butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A or its derivatives Body, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ or derivatives thereof, vitamin B ₁₂ such as vitamin B ₁₂ , vitamin B ₁₅ or derivatives thereof; α-tocopherol, β-tocopherol , .gamma.-tocopherol, vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, pantethine, vitamins pyrroloquinoline quinone such like; antibacterial agents such as phenoxyethanol or the like can be preferably exemplified.

As mentioned above, the external preparation for skin of the present invention contains a port Rieteru modified methylpolysiloxane. The polyether structure constituting or mow port Rieteru modified methylpolysiloxane, polyethylene glycol residue or a polypropylene glycol residue can be preferably exemplified, polyethylene glycol residues are particularly preferred. The such port Rieteru modified methyl polysiloxane commercially resides, it can be utilized to purchase such commercially. Preferred commercially available products sold by Shin-Etsu Chemical Co., Ltd. "Silicone KF6017", "Silicone KF6018" (Po triethylene glycol-modified methylpolysiloxane) can be suitably exemplified. This component has the effect of further stabilizing the emulsified structure formed by the organically modified clay mineral, which is the essential component, and reducing the feeling of use when the aqueous phase leaks out during rubbing on the skin during application. Improve. To achieve such a effect, positive Rieteru modified methylpolysiloxane preferably contains 1 to 10 wt%, more preferably, more preferably 2 to 7 wt%.

Similarly, the skin external preparation of the present invention to enhance the gel structure in the sense that to strengthen the internal phase structure, polymethacryloylacetones Le lysine, poly-glucosyl ethyl methacrylate, moisturizing polymer selected from polymethacryloylacetones oxyethyl phosphorylcholine Containing . In order to exhibit such an effect, the moisturizing polymer is preferably added in a total amount of 0.01 to 0.1% by mass based on the total amount of the external preparation for skin. There are cases where the stability is impaired if there are too many or too few such components.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

<Reference Example 1>
A cosmetic was prepared according to the formulation shown below. That is, the ingredients (a), (b), (c), and (d) are heated to 80 ° C., the ingredients (a) and (b) are kneaded well, added to this to dilute, and gradually added to the mixture with stirring. The mixture was emulsified, cooled with stirring, and a water-in-oil emulsifier type cosmetic 1 (anti-inflammatory pharmaceutical quasi-drug) was obtained.

<Example 1>
Cosmetic 2 was prepared with the same composition as cosmetic 1 but with the dosage form changed to an oil-in-water oil-in-water emulsifier. That is, each of the ingredients i, b, c, d, and e is heated to 80 ° C., the ingredients a and b are kneaded well, added with c, diluted, and stirred, The oil-in-water emulsion prepared by adding 2 was gradually added to form an oil-in-water oil-in-water emulsifier form, and stirred and cooled to obtain a cosmetic 2.

<Test Example 1>
Using the cosmetics 1 and 2, the effect on the damaged skin model in which mental stress was involved was confirmed. Along with cosmetic 1, a comparative example 1 in which Benton-38V of cosmetic 1 is replaced with silicone KF6017 and a comparative example 2 in which Erdeu PS203 is replaced with decamethylcyclopentasiloxane are prepared, and 10 panelists are packed into 3 tatami mats for 1 hour. Then, measure 5 parts of 2cm x 4cm provided on the forearm, TEWL (percutaneous dissipated moisture) of each part with "Tevameter" (manufactured by Integral), stripping 10 times with adhesive tape Then, 40 μl of Cosmetic 1, Cosmetic 2, Comparative Example 1, and Comparative Example 2 were put on each part, and rubbing was continued for 5 minutes. One site was damaged only as a control. After 5 minutes, the cosmetic was washed away with soap and hot water, allowed to stand for 15 minutes, and TEWL was measured again. The TEWL suppression rate was calculated according to the following equation. The results are shown in Table 3 as average values. At the same time, Table 3 also shows the results of a survey conducted by the panelists in a three-choice form of feeling pleasant when scratched, especially feeling nothing, and being uncomfortable. It can be seen that the cosmetic 1 suppresses skin troubles caused by overstress stress and skin damage due to good usability. It can also be seen that the cosmetic 2 further enhances this effect even though the composition is the same.
(1- (TEWL of site after treatment-TEWL of site before test) / (TEWL of control site after treatment-TEWL of control site before test)) * 100

<Reference Example 2>
In the same manner as in Example 1, cosmetic 3 (anti-inflammatory quasi-drug) was produced according to the following formulation. The TEWL suppression rate of Test Example 1 was 64.3% (n = 1). It can be seen that preferably contains a port Rieteru modified siloxane.

<Reference Example 3>
In the same manner as in Example 1, cosmetic 4 (anti-inflammatory pharmaceutical quasi-drug) was produced according to the following formulation. The TEWL suppression rate of Test Example 1 was 62.9% (n = 1). It can be seen that it is preferable to contain a moisturizing polymer.

<Example 2>
In the same manner as in Example 1, cosmetic 5 (anti-inflammatory pharmaceutical quasi-drug) was produced according to the following formulation. The TEWL suppression rate of Test Example 1 was 68.9% (n = 1). It turns out that N-acyl glutamic acid diester can be used widely. It can also be seen that N-lauroyl glutamate di (phytosteryl / octyldodecyl) is particularly preferable.

  The present invention can be applied to cosmetics.

Claims (3)

A skin external preparation in the form of an oil-in-water oil emulsifier,
The outer phase oil contains 1) an organically modified clay mineral, 2) a polyether-modified methylpolysiloxane, and 3 ) an N-acyl (10 to 30 carbon atoms) dialkyl glutamate (1 to 30 carbon atoms) ester ,
In the aqueous phase, 4) polymethacryloylacetones Le lysine, characterized in that it contains a moisturizing polymer selected from poly glucosyl methacrylate and polymethacryloylacetones oxyethyl phosphorylcholine, leather Hadagaiyo agent.   The skin external application according to claim 1, wherein the N-acyl (C10-C30) dialkyl glutamate (C1-30) ester is N-lauroylglutamate di (phytosteryl / octyldodecyl). Agent. Wherein the polyether portion constituting the port Rieteru modified methylpolysiloxane is a polyethylene glycol, a skin external preparation according to claim 1 or 2.