JP5635223B2 - Skin external preparation suitable for esthetic treatment - Google Patents

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable as a cosmetic for skin protection.

  The present age is an era of stress overload, and in the present age, how to effectively reduce the stress that has been overloaded has become an important issue in operating social life. Against this background, “esthetics” that stimulate the skin that is the sensory organs and reduce stress on the mind and body are becoming popular, and in large cities, esthetic salons are often found in towns. ing. Esthetics basically consists of massage treatments that impart good stimuli to the skin, and skin care treatments consisting of skin protection and pack cosmetics. Increasing the stimulus transmission assisting effect of cosmetics used in such treatments is an important factor in aesthetic cosmetics and has been desired.

On the other hand, organically modified clay minerals are used in skin external preparations such as cosmetics as thickeners having an emulsifying action, and are particularly known to have an excellent emulsion stabilizing action in a water-in-oil emulsifier form . Tei Ru (e.g., Patent documents 1 and 2, refer to Patent Document 3), for the polyglycerol having a degree of polymerization of 2 to 5, for use in a skin external preparation such as cosmetics as high polyhydric alcohol moisturizing it is that known (e.g., refer to Patent Document 4, Patent Document 5, Patent Document 6). However, there is no known skin external preparation containing 1) an organically modified clay mineral , 2) polyglycerin having a polymerization degree of 2 to 5 , 3) ethylene oxide / methylsiloxane copolymer, and 4) glycerin . It has not been known at all that it can have the characteristics as a skin external preparation suitable for creating a benign stimulus in esthetic treatment, and in a complex emulsifier form such as oil-in-water-in-oil. It has also never been known to produce more suitable stimuli.

JP 2005-255623 A JP 2004-292373 A JP 2001-58937 A JP 2004-137249 A Japanese Patent Laid-Open No. 10-025224 JP 2005-206573 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide a skin external preparation suitable for creating a good stimulus in esthetic treatment.

In view of such a situation, the present inventors have sought for a skin external preparation suitable for creating good irritation in esthetic treatment, and as a result of intensive research efforts, 1) organically modified clay minerals and To find out that a skin external preparation containing 2) polyglycerin having a polymerization degree of 2 to 5, 3) ethylene oxide / methylsiloxane copolymer, and 4) glycerin has such characteristics, and to complete the invention. It came. That is, this invention relates to the technique shown below.
(1) 1) 0.5 to 10% by mass of an organically modified clay mineral, 2) 0.5 to 5% by mass of polyglycerin having a degree of polymerization of 2 to 5, and 3) 1 to 10% by mass of an ethylene oxide / methylsiloxane copolymer 4) A skin external preparation in the form of a water-in-oil emulsifier or an oil-in-water emulsifier in oil, containing 10 to 30% by mass of glycerin.
(2) The external preparation for skin according to (1), wherein the polyglycerin having a polymerization degree of 2 to 5 is diglycerin.
(3) The external preparation for skin according to (1) or (2), which is a skin protective agent prior to pack treatment in esthetics.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation suitable for creating good irritation | stimulation can be provided in esthetic treatment.

(1) Organically modified clay mineral which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing an organically modified clay mineral as an essential component. Here, organic modification means that a part or all of the properties of an organic compound is made into a clay mineral by causing a part of the organic compound to form a strong or loose bond via a covalent bond or an ionic bond. This means that it is imparted to minerals. Examples of such modifications include a method of binding a quaternary amine group and an anion portion of a clay mineral, and a method of binding a carboxyl group and a cation portion of a clay mineral. A method of combining the group and the anion portion of the clay mineral is particularly preferable.

  Although it does not necessarily limit as a compound which has a quaternary amino group which modifies a clay mineral, The compound called quaternium is illustrated. Quotanium is a low molecular weight substituted quaternary ammonium salt, and is preferably a cosmetic raw material registered in International Standard Cosmetic Ingredients (INCI). Furthermore, the compound having a quaternary amino group that modifies the clay mineral is preferably a quaternium compound contained in a conventional external skin preparation among quaternium compounds. Preferred examples of the quaternium compound used in conventional external preparations for skin include stearyl trimethyl ammonium chloride and dimethyl distearyl ammonium chloride. Stearyl trimethyl ammonium chloride, dimethyl distearyl ammonium chloride and the like are preferable because they can form a stable water-in-oil emulsion structure together with clay minerals.

  On the other hand, as a clay mineral (unmodified clay mineral) modified with a compound having a quaternary amino group, any clay mineral contained in a conventional external preparation for skin can be used without particular limitation. Preferred clay minerals contained in conventional skin external preparations include smectite-type hectorite, bentonite and montmorillonite; kaolinite; illite; marine clay mineral (sea mud); desert rose clay mineral; Among these, bentonite, hectorite, montmorillonite or kaolinite which can stabilize the water-in-oil emulsion structure is preferably exemplified.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersant is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by taking such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Or the modified clay mineral in this invention can also be obtained by removing a dispersing agent by concentrating under reduced pressure without filtering a dispersoid, and making it dry. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

  The modified clay mineral in the present invention can be prepared and used as described above, but a commercially available one can also be used. Some modified clay minerals on the market are used as external preparations for skin such as cosmetics. Preferable examples of commercially available modified clay minerals include dimethyl distearyl ammonium modified hectorite sold under the name “Benton 38V” by Elementis.

In the external preparation for skin of the present invention, such component is 0.5 to 10 mass% containing chromatic, and more preferably is contained 1-5 wt%. Such a component acts as an emulsifier within the above-mentioned content range, and at the same time, in the feeling of use at the time of application, the applied person feels comfortable by the pattern of change of the coefficient of friction at the time of application and application. Therefore, it has the effect of relaxing and relieving stress. This enhances the esthetic treatment effect and increases the creation of good stimuli.

(2) Polyglycerin which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing polyglycerin having a polymerization degree of 2 to 5 as an essential component. Specific examples of the polyglycerin having a polymerization degree of 2 to 5 are preferably diglycerin, triglycerin, and tetraglycerin, and more preferably diglycerin and triglycerin. Such a component improves the moist feeling and adhesion feeling during spreading in the external preparation for skin of the present invention, thereby creating comfort for the patient. Such an effect can be obtained to some extent by adding glycerin, but in esthetics, it is extremely large as a sufficient amount for realizing good stimuli. It must be said that it is impossible. In order to embody such an effect, the polyglycerin may contain only one species or may contain two or more species in combination. In the external preparation for skin of the present invention, including Yuryou of such polyglycerols, in total, relative to the total amount of the skin treatment composition is 0.5 to 5 wt%, more preferably from 1 to 3 wt%.

(3) External preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing the above essential components , glycerin and an ethylene oxide / methylsiloxane copolymer described later . The external preparation for skin of the present invention can be applied without particular limitation as long as it is used externally on the skin. For example, cosmetics including quasi-drugs, pharmaceutical compositions for external use on skin, and miscellaneous goods for external use Etc. can be suitably exemplified. Among these, it is preferable to apply to cosmetics, and in particular, it is preferable to use it for under cream used for the purpose of skin conditioning and skin protection prior to pack treatment in esthetics. Such an under cream is a cosmetic that has the effect of formulating a moisturizing component together with an emollient component for the purpose of further enhancing the effect of the pack cosmetic, and allowing these components to penetrate into the skin by pack treatment. As the dosage form water-in-oil emulsifier type include oil-in-water-oil emulsifier type. Preferred dosage forms especially, the in-oil water-in-oil emulsifier type that Ikase characteristics of the organic modified clay mineral.

Since the skin external preparation of this invention contains an organic modified clay mineral as an essential component, in order to improve the emulsifiability of this thing, 10-30 mass% of glycerol other than the said polyglycerol, More preferably, it is 15-25. containing mass%. In addition, although it is a snake leg, when the content of glycerin is 25% by mass, the moist feeling and the feeling of adhesion at the time of spreading are not sufficiently improved. When the amount is out of the range, the emulsifiability improvement of the organically modified clay mineral may be impaired.

Further, as described above, it contains an ethylene oxide / methylsiloxane copolymer in order to improve the emulsion stability of the external preparation for skin of the present invention. Among these, particularly preferable examples include “silicone KF6017” and “silicone KF6018” (ethylene oxide / methylsiloxane copolymer) sold by Shin-Etsu Chemical Co., Ltd. Such a copolymer may contain only one species or a combination of two or more species. Containing Yuryou of such components are in a total amount, relative to the total amount of the skin treatment composition, 1 to 10 wt%, more preferably from 2 to 6 wt%. If the amount is out of this range, the stability improving effect may be impaired.

In addition, the external preparation for skin of the present invention preferably contains a diester of N-acylglutamic acid having an action of enhancing the stratum corneum permeability of the active ingredient. Preferred examples of such a diester of N-acylglutamic acid include N-lauroylglutamate di (phytosteryl / octyldodecyl), for example, N-lauroylglutamate di (cholesteryl / octyldodecyl / behenyl), and the like. Such diesters already have commercial products, and such commercial products can be purchased and used. As such a preferable commercially available product, for example, “El Dew PS203” (N-lauroylglutamate di (phytosteryl / octyldodecyl)) sold by Ajinomoto Co., Inc. can be preferably exemplified. In the external preparation for skin of the present invention, such a component can contain only one species or two or more species. The total content of such components is 0.1 to 10% by mass, more preferably 1 to 5% by mass, based on the total amount of the external preparation for skin. In the oil-in-water oil-in-water emulsifier form, it is particularly preferable that such a component is contained in the outermost oil phase because the above-mentioned effect can be easily obtained.

  Furthermore, since the moisture retention property of the skin can be further improved, it is also preferable to contain one or more selected from polymethacryloyl lysine, polymethacryloyloxyethyl phosphorylcholine, polyglucosylethyl methacrylate, and salts thereof. By increasing the moisturizing property, the satisfaction after the treatment is improved, and thus the stress reducing effect can be enhanced. The preferable content of such components is 0.05 to 0.5% by mass, more preferably 0.1 to 0.3% by mass.

In the external preparation for skin of the present invention, in addition to the essential components and preferred components, optional components that are usually used in external preparations for skin can be contained. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oils such as beeswax, molasses, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax; liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Ethers (POE- glyceryl monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate and the like), POE alkyl ethers (PO
E2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil・ Nonionic surfactants such as hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.), sucrose fatty acid ester, alkyl glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol , Maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanedio Moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate; surface treated mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (Silica), powders such as aluminum oxide and barium sulfate; inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide, which may be treated on the surface Pearl agents such as mica titanium, fish phosphorus foil, bismuth oxychloride, etc. whose surface may be treated; red 202, red 228, red 226, yellow 4 that may be raked, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Organic dyes such as color 201, purple 201 and red 204; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; paraaminobenzoic acid UV absorbers; anthranilic acid UV absorber; salicylic acid UV absorber; cinnamic acid UV absorber; benzophenone UV absorber; sugar UV absorber; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4- UV absorbers such as methoxy-4′-t-butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A or derivatives thereof, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate , vitamin B ₂ or derivatives thereof, vitamin B _12, vitamin B ₁₅ or Vitamin Bs such as derivatives thereof; Vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, vitamins such as pantothenic acid, panthetin, pyrroloquinoline quinone, etc .; Preferred examples include antibacterial agents such as phenoxyethanol. The external preparation for skin of the present invention can be produced by treating these components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

<Example 1>
According to the formulation shown in Table 1 below, a cosmetic preparation in the form of a cream, which is an external preparation for skin of the present invention (quasi-drugs that promoted anti-inflammatory action), was produced. In other words, the ingredients (a), (c) and (d) are heated to 75 ° C., (b) is added to (b) and dispersed uniformly, and an emulsion prepared by adding (c) to (d) in advance is gradually added to this while stirring. It was cooled under the rear stirring to obtain a cream 1 of oil-in-water-oil emulsion formulation.

<Example 2>
A cream 2 in the form of a water-in-oil emulsifier, which is an external preparation for skin of the present invention, was prepared with the same composition as cream 1. That is, the ingredients of A and C are each heated to 75 ° C., and B is added to A and dispersed uniformly. While stirring, the mixture is gradually added and stirred and cooled to form a water-in-oil emulsifier type cream. 2 was obtained.

<Test Example 1>
Along with Comparative Example 1 in which “Benton 38V” of Cream 1 and Cream 1 was replaced with water, Comparative Example 2 in which diglycerin was replaced with glycerin, and Cream 2, usability as an under cream in esthetic treatment was tested. Prepare 16 panelists and divide them into 3 groups of 4 so that there is no group variation. Cleanse → Massage → Applying under cream → Packing treatment course. Used cream 1, 1 group used cream 2, 1 group used comparative example 1, and 1 group used comparative example 2. Saliva was collected from the subject before and after the treatment, and the concentration of dehydroepiandrosterone (DHEA) was quantified by the sandwich antibody method. The DHEA increase rate (%) was calculated from the formula of (post-operative DHEA concentration−pre-operative DHEA concentration) / (pre-operative DHEA concentration) × 100. The average of this value was calculated for each group. The results are shown in Table 3. From this, it can be seen that the external preparation for skin of the present invention is excellent in the effect of increasing DHEA, which is an index substance of pleasure, and thus is excellent in the imparting effect of aesthetic feeling. Moreover, as a dosage form, it turns out that the oil-in-water oil-in-water emulsifier form is preferable.

<Reference Example 1>
As in Example 1, in accordance with the formulation shown in Table 4, were prepared cream 3 (quasi-drug that appeal anti-inflammatory effect) is a skin Hadagaiyo agent. Was evaluated according to the ones in Test Example 1, the rate of increase in DHEA in 15.7 ± 6.6 (%), it was found that preferably contains ethylene oxide-methylsiloxane copolymer.

<Reference Example 2>
As in Example 1, in accordance with the formulation shown in Table 5, intradermal Hadagaiyo agent der torque stream 4 (quasi drug that appeal anti-inflammatory effects) was prepared. The evaluation result according to Test Example 1 is that the DHEA increase rate is 13.6 ± 5.9 (%), and it is preferable that a form containing 10-30% by mass of glycerin and 1-5% by mass of diglycerin is preferable. It was.

<Example 3>
In the same manner as in Example 1, according to the formulation shown in Table 6, cream 5 (quasi-drug that appealed anti-inflammatory effect), which is an external preparation for skin of the present invention, was produced. In the evaluation of Test Example 1, it was 21.1 ± 6.7 (%).

<Test Example 2>
For each of Cream 1 and Cream 5 , use 5 panelists, and measure TEWL (transcutaneous dissipated water) using “Tevameter” (manufactured by Integral) before and after esthetic treatment. The TEWL improvement rate was measured by the following formula: TEWL of post-operative TEWL) / (preoperative TEWL) * 100. As a result, Cream 1 is 23.6 ± 15.1%, whereas Cream 5 is 17.9 ± 14.8, and the addition of “El Deu PS203” improves the absorbability of the active ingredient. It has been suggested.

 The present invention can be applied to skin external preparations such as quasi drugs.

Claims (3)

1) 0.5 to 10% by mass of organically modified clay mineral, 2) 0.5 to 5% by mass of polyglycerin having a polymerization degree of 2 to 5, 3) 1 to 10% by mass of ethylene oxide / methylsiloxane copolymer, and 4) A skin external preparation in the form of a water-in-oil emulsifier or an oil-in-water oil-in-water emulsifier for esthetic treatment , comprising 10 to 30% by mass of glycerin.   The external preparation for skin according to claim 1, wherein the polyglycerin having a polymerization degree of 2 to 5 is diglycerin. Characterized in that it is a skin protection fee prior to packs practitioner, skin external preparation according to claim 1 or 2.