JP2008013517A - Skin care preparation suitable for esthetic treatment - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a skin care preparation suitable for producing a good stimulation in an esthetic treatment. <P>SOLUTION: The skin care preparation comprises (1) an organic modified clay mineral and (2) a polyglycerin having a polymerization degree of 2-5. Preferably the skin care preparation comprises further an alkylene oxide methylsiloxane copolymer. Preferably the skin care preparation contains 10-30 mass% of glycerin and is an oil-in-water-in-oil type dosage form. Especially preferably, the skin care preparation is a skin protection agent before pack treatment in aesthetics. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable as a cosmetic for skin protection.

  The present age is an era of stress overload, and in the present age, how to effectively reduce the stress that has been overloaded has become an important issue in operating social life. Against this background, “esthetics” that stimulate the skin that is the sensory organs and reduce stress on the mind and body are becoming popular, and in large cities, esthetic salons are often found in towns. ing. Esthetics basically consists of massage treatments that impart good stimuli to the skin, and skin care treatments consisting of skin protection and pack cosmetics. Increasing the stimulus transmission assisting effect of cosmetics used in such treatments is an important factor in aesthetic cosmetics and has been desired.

  On the other hand, organically modified clay minerals are used in skin external preparations such as cosmetics as thickeners having an emulsifying action, and are particularly known to have an excellent emulsion stabilizing action in a water-in-oil emulsifier type. (For example, see Patent Document 1, Patent Document 2, and Patent Document 3) Polyglycerin having a degree of polymerization of 2 to 5 is used as a polyhydric alcohol having a high moisturizing effect in skin external preparations such as cosmetics. It is known. (For example, refer to Patent Document 4, Patent Document 5, and Patent Document 6) However, there is no known skin external preparation containing 1) an organically modified clay mineral and 2) polyglycerin having a polymerization degree of 2 to 5, It was not known at all that it was possible to have the characteristics as a skin external preparation suitable for creating a good stimulus in esthetic treatment by taking such a configuration, and a complex emulsifier such as oil-in-water in oil It has also never been known to extract more favorable stimuli in form.

JP 2005-255623 A JP 2004-292373 A JP 2001-58937 A JP 2004-137249 A Japanese Patent Laid-Open No. 10-025224 JP 2005-206573 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide a skin external preparation suitable for creating a good stimulus in esthetic treatment.

In view of such a situation, the present inventors have sought for a skin external preparation suitable for creating good irritation in esthetic treatment, and as a result of intensive research efforts, 1) organically modified clay minerals and 2) It has been found that an external preparation for skin containing polyglycerin having a polymerization degree of 2 to 5 has such characteristics, and has completed the invention. That is, this invention relates to the technique shown below.
(1) A skin external preparation characterized by containing 1) an organically modified clay mineral and 2) polyglycerin having a polymerization degree of 2 to 5.
(2) The external preparation for skin according to (1), further comprising an alkylene oxide / methylsiloxane copolymer.
(3) The external preparation for skin according to (1) or (2), further comprising 10 to 30% by mass of glycerin.
(4) The external preparation for skin according to any one of (1) to (3), which is an oil-in-water emulsifier type in oil.
(5) The external preparation for skin according to any one of (1) to (4), which is a skin protective agent prior to pack treatment in esthetics.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation suitable for creating good irritation | stimulation can be provided in esthetic treatment.

(1) Organically modified clay mineral which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing an organically modified clay mineral as an essential component. Here, organic modification means that a part or all of the properties of an organic compound is made into a clay mineral by causing a part of the organic compound to form a strong or loose bond via a covalent bond or an ionic bond. This means that it is imparted to minerals. Examples of such modifications include a method of binding a quaternary amine group and an anion portion of a clay mineral, and a method of binding a carboxyl group and a cation portion of a clay mineral. A method of combining the group and the anion portion of the clay mineral is particularly preferable.

  Although it does not necessarily limit as a compound which has a quaternary amino group which modifies a clay mineral, The compound called quaternium is illustrated. Quotanium is a low molecular weight substituted quaternary ammonium salt, and is preferably a cosmetic raw material registered in International Standard Cosmetic Ingredients (INCI). Furthermore, the compound having a quaternary amino group that modifies the clay mineral is preferably a quaternium compound contained in a conventional external skin preparation among quaternium compounds. Preferred examples of the quaternium compound used in conventional external preparations for skin include stearyl trimethyl ammonium chloride and dimethyl distearyl ammonium chloride. Stearyl trimethyl ammonium chloride, dimethyl distearyl ammonium chloride and the like are preferable because they can form a stable water-in-oil emulsion structure together with clay minerals.

  On the other hand, as a clay mineral (unmodified clay mineral) modified with a compound having a quaternary amino group, any clay mineral contained in a conventional external preparation for skin can be used without particular limitation. Preferred clay minerals contained in conventional skin external preparations include smectite-type hectorite, bentonite and montmorillonite; kaolinite; illite; marine clay mineral (sea mud); desert rose clay mineral; Among these, bentonite, hectorite, montmorillonite or kaolinite which can stabilize the water-in-oil emulsion structure is preferably exemplified.

An example of a method for producing a clay mineral modified with a compound having a quaternary amino group contained in the external preparation for skin of the present invention will be described below.
The unmodified clay mineral is dispersed in a dispersion medium. The dispersant is preferably an aqueous solvent, and may be water. A compound having a quaternary amino group is further added to the dispersion containing the dispersed unmodified clay mineral and stirred well. The compound having a quaternary amino group may be added after being dissolved in water. The amount of the compound having a quaternary amino group to be added is preferably 0.1 to 20% by mass, and more preferably 0.5 to 15% by mass with respect to the amount of the dispersed unmodified clay mineral. This is because by taking such a configuration, a preferable feeling of use is exhibited in the emulsification system. After stirring, the dispersoid is filtered, dehydrated and dried to obtain the modified clay mineral in the present invention. Or the modified clay mineral in this invention can also be obtained by removing a dispersing agent by concentrating under reduced pressure without filtering a dispersoid, and making it dry. The obtained modified clay mineral is preferably pulverized to a desired size (preferably having a particle size of 1 to 1000 μm) and contained in the skin external preparation of the present invention.

  The modified clay mineral in the present invention can be prepared and used as described above, but a commercially available one can also be used. Some modified clay minerals on the market are used as external preparations for skin such as cosmetics. Preferable examples of commercially available modified clay minerals include dimethyl distearyl ammonium modified hectorite sold under the name “Benton 38V” by Elementis.

  In the skin external preparation of this invention, this component is contained preferably 0.5-10 mass%, More preferably, 1-5 mass% is contained. Such a component acts as an emulsifier within the above-mentioned content range, and at the same time, in the feeling of use at the time of application, the applied person feels comfortable by the pattern of change of the coefficient of friction at the time of application and application. Therefore, it has the effect of relaxing and relieving stress. This enhances the esthetic treatment effect and increases the creation of good stimuli.

(2) Polyglycerin which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing polyglycerin having a polymerization degree of 2 to 5 as an essential component. Specific examples of the polyglycerin having a polymerization degree of 2 to 5 are preferably diglycerin, triglycerin, and tetraglycerin, and more preferably diglycerin and triglycerin. Such a component improves the moist feeling and adhesion feeling during spreading in the external preparation for skin of the present invention, thereby creating comfort for the patient. Such an effect can be obtained to some extent by adding glycerin, but in esthetics, it is extremely large as a sufficient amount for realizing good stimuli. It must be said that it is impossible. In order to embody such an effect, the polyglycerin may contain only one species or may contain two or more species in combination. In the external preparation for skin of the present invention, the preferable content of polyglycerin is 0.5 to 5% by mass, more preferably 1 to 3% by mass, based on the total amount of external preparation for skin.

(3) The skin external preparation of this invention The skin external preparation of this invention contains the said essential component, It is characterized by the above-mentioned. The external preparation for skin of the present invention can be applied without particular limitation as long as it is used externally on the skin. For example, cosmetics including quasi-drugs, pharmaceutical compositions for external use on skin, and miscellaneous goods for external use Etc. can be suitably exemplified. Among these, it is preferable to apply to cosmetics, and in particular, it is preferable to use it for under cream used for the purpose of skin conditioning and skin protection prior to pack treatment in esthetics. Such an under cream is a cosmetic that has the effect of formulating a moisturizing component together with an emollient component for the purpose of further enhancing the effect of the pack cosmetic, and allowing these components to penetrate into the skin by pack treatment. The dosage form is not particularly limited, and preferred examples include oil-in-water emulsifier type, water-in-oil emulsifier type, multi-phase emulsifier type such as oil-in-water oil-in-water emulsifier type, and non-water emulsifier type. A particularly preferable dosage form is a multi-phase emulsifier form that makes use of the characteristics of the organically modified clay mineral, and among them, an oil-in-water-in-oil emulsifier form.

  Since the skin external preparation of this invention contains an organic modified clay mineral as an essential component, in order to improve the emulsifiability of this thing, 10-30 mass% of glycerol other than the said polyglycerol, More preferably, it is 15-25. It is preferable to contain by mass. In addition, although it is a snake leg, when the content of glycerin is 25% by mass, the moist feeling and the feeling of adhesion at the time of spreading are not sufficiently improved. When the amount is out of the above range, the emulsifiability improvement of the organically modified clay mineral may be impaired.

  Moreover, it is preferable to contain an alkylene oxide methylsiloxane copolymer in the meaning which improves the emulsification stability of the external preparation for skin of this invention. Preferred examples of the alkylene oxide / methyl siloxane copolymer include an ethylene oxide / methyl siloxane copolymer, a propylene oxide / methyl siloxane copolymer, and an ethylene oxide / propylene oxide / methyl siloxane copolymer, which may partially have a crosslinked structure. It is. Among these, particularly preferable examples include “silicone KF6017” and “silicone KF6018” (ethylene oxide / methylsiloxane copolymer) sold by Shin-Etsu Chemical Co., Ltd. Such a copolymer may contain only one species or a combination of two or more species. The preferable content of such components is 1 to 10% by mass, more preferably 2 to 6% by mass, based on the total amount of the external preparation for skin, as a total amount. If the amount is out of this range, the stability improving effect may be impaired.

  In addition, the external preparation for skin of the present invention preferably contains a diester of N-acylglutamic acid having an action of enhancing the stratum corneum permeability of the active ingredient. Preferred examples of such a diester of N-acylglutamic acid include N-lauroylglutamate di (phytosteryl / octyldodecyl), for example, N-lauroylglutamate di (cholesteryl / octyldodecyl / behenyl), and the like. Such diesters already have commercial products, and such commercial products can be purchased and used. As such a preferable commercially available product, for example, “El Dew PS203” (N-lauroylglutamate di (phytosteryl / octyldodecyl)) sold by Ajinomoto Co., Inc. can be preferably exemplified. In the external preparation for skin of the present invention, such a component can contain only one species or two or more species. The total content of such components is 0.1 to 10% by mass, more preferably 1 to 5% by mass, based on the total amount of the external preparation for skin. In the oil-in-water oil-in-water emulsifier form, it is particularly preferable that such a component is contained in the outermost oil phase because the above-mentioned effect can be easily obtained.

  Furthermore, since the moisture retention property of the skin can be further improved, it is also preferable to contain one or more selected from polymethacryloyl lysine, polymethacryloyloxyethyl phosphorylcholine, polyglucosylethyl methacrylate, and salts thereof. By increasing the moisturizing property, the satisfaction after the treatment is improved, and thus the stress reducing effect can be enhanced. The preferable content of such components is 0.05 to 0.5% by mass, more preferably 0.1 to 0.3% by mass.

  In the external preparation for skin of the present invention, in addition to the essential components and preferred components, optional components that are usually used in external preparations for skin can be contained. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oils such as beeswax, owl, hardened castor oil, beeswax, candelilla wax, carnauba wax, botarou, lanolin, reduced lanolin, hard lanolin, jojoba wax , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (eg, glyceryl monostearate), propylene glycol fatty acid esters (eg, propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyhydric alcohols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidonecarboxylate Moisturizing ingredients such as lactic acid and sodium lactate; powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc. whose surface may be treated Body, the surface may be treated, inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface may be treated, mica Pearl agents such as titanium, fish phosphorus foil, bismuth oxychloride; red 202 which may be raked, red Color 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue 1 No., green 201, purple 201, red 204, etc .; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; para-aminobenzoic acid UV absorbers; anthranils Acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzo Ultraviolet absorbers such as triazole and 4-methoxy-4′-t-butyldibenzoylmethane; lower grades such as ethanol and isopropanol Alcohols; vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B such as vitamin B12, vitamin B15 or derivatives thereof; α-tocopherol, β- Preferred examples include vitamins such as tocopherol, γ-tocopherol, vitamin E acetate and the like, vitamins D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone, and the like; and antibacterial agents such as phenoxyethanol. The external preparation for skin of the present invention can be produced by treating these components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  According to the formulation shown in Table 1 below, a cream type cosmetic (a quasi-drug that promoted anti-inflammatory action), which is an external preparation for skin of the present invention, was produced. In other words, the ingredients (a), (c) and (d) are heated to 75 ° C., (b) is added to (b) and dispersed uniformly, and an emulsion prepared by adding (c) to (d) in advance is gradually added to this while stirring. After cooling with stirring, an oil-in-water oil-type cream 1 was obtained.

  A cream 2 in the form of a water-in-oil emulsifier with the same composition as cream 1 was also prepared. That is, the ingredients of A and C are each heated to 75 ° C., and B is added to A and dispersed uniformly. While stirring, the mixture is gradually added and stirred and cooled to form a water-in-oil emulsifier type cream. 2 was obtained.

<Test Example 1>
Along with Comparative Example 1 in which “Benton 38V” of Cream 1 and Cream 1 was replaced with water, Comparative Example 2 in which diglycerin was replaced with glycerin, and Cream 2, usability as an under cream in esthetic treatment was tested. Prepare 16 panelists and divide them into 3 groups of 4 so that there is no group variation. Cleanse → Massage → Apply under cream → Pack treatment course and receive esthetic treatment. Used cream 1, 1 group used cream 2, 1 group used comparative example 1, and 1 group used comparative example 2. Saliva was collected from the subject before and after the treatment, and the concentration of dehydroepiandrosterone (DHEA) was quantified by the sandwich antibody method. The DHEA increase rate (%) was calculated from the formula of (post-operative DHEA concentration−pre-operative DHEA concentration) / (pre-operative DHEA concentration) × 100. The average of this value was calculated for each group. The results are shown in Table 3. From this, it can be seen that the external preparation for skin of the present invention is excellent in the effect of increasing DHEA, which is an index substance of pleasure, and thus is excellent in the imparting effect of aesthetic feeling. Moreover, as a dosage form, it turns out that the oil-in-water oil-in-water emulsifier form is preferable.

  In the same manner as in Example 1, according to the formulation shown in Table 3, cream 3 (quasi-drug that promoted anti-inflammatory action) as an external preparation for skin of the present invention was produced. When this product was evaluated according to Test Example 1, it was found that the increase rate of DHEA was 15.7 ± 6.6 (%), and it was preferable to contain an alkylene oxide / methylsiloxane copolymer.

  Similarly to Example 1, according to the formulation shown in Table 4, cream 3 (quasi-drug that appealed anti-inflammatory action), which is an external preparation for skin of the present invention, was produced. The evaluation result according to Test Example 1 is that the DHEA increase rate is 13.6 ± 5.9 (%), and it is preferable that a form containing 10-30% by mass of glycerin and 1-5% by mass of diglycerin is preferable. It was.

  In the same manner as in Example 1, according to the formulation shown in Table 5, cream 4 (quasi-drug that appealed anti-inflammatory action) as an external preparation for skin of the present invention was produced. In the evaluation of Test Example 1, it was 21.1 ± 6.7 (%).

<Test Example 2>
For each of cream 1 and cream 4, five panelists were used, and TEWL (percutaneous dissipated water content) was measured using “Tevameter” (manufactured by Integral) before and after the treatment. -TEWL improvement rate was measured by the formula of TEWL after surgery) / (TEWL before surgery) * 100. As a result, cream 1 is 23.6 ± 15.1%, while cream 4 is 17.9 ± 14.8, and the absorption of the active ingredient is improved by the addition of “El Deu PS203”. It has been suggested.

  The present invention can be applied to skin external preparations such as quasi drugs.

Claims (5)

An external preparation for skin comprising 1) an organically modified clay mineral and 2) polyglycerin having a degree of polymerization of 2 to 5. The skin external preparation according to claim 1, further comprising an alkylene oxide / methyl siloxane copolymer. Furthermore, 10-30 mass% of glycerol is contained, The skin external preparation of Claim 1 or 2 characterized by the above-mentioned. The skin external preparation according to any one of claims 1 to 3, which is an oil-in-water emulsifier type in oil. In aesthetics, the skin external preparation according to any one of claims 1 to 3, which is a skin protective agent prior to pack treatment.