JP2007099658A - Oil-in-water type moisturizing skin care external preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care external preparation having protective function enough to deal with environmental stress. <P>SOLUTION: The skin care external preparation is of oil-in-water type emulsion dosage form and contains (1) a (partially modified) crosslinked type methylpolysiloxane and also includes (2) 15-35 mass% of a polyhydric alcohol and (3) 20-35 mass% of water. In this skin care preparation, the above (partially modified) crosslinked type methylpolysiloxane is selected preferably from crosslinked methylpolysiloxane, crosslinked phenylmethylpolysiloxane and polyether-modified methylpolysiloxane, and its content is preferably 1-10 mass%. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a skin external preparation, and more particularly to a skin external preparation suitable for a cosmetic having a protective function capable of resisting environmental stress.

  Modern times are said to be an era of excessive stress, and due to the impact of social conditions such as the economic downturn, the number of people who commit suicide from excessive stress exceeds the number of people who have already died in traffic accidents. ing. Such overload stress is known to affect the skin condition, and various active ingredients have been developed to improve such loss of skin function by alleviating the stress. (For example, see Patent Document 1, Patent Document 2, Patent Document 3, Patent Document 4, and Patent Document 5) However, with such a component alone, the skin condition is not recovered until the function that is actually impaired is recovered. Since it is in a damaged state, it tends to cause an inflammatory response due to a stimulus, and this also causes a deterioration, so it took a considerable time to exert its effect. In that sense, the above-mentioned measures were not sufficient.

  On the other hand, it is known that cross-linked methylpolysiloxane and partially modified products thereof have an effect of improving the longevity of cosmetics and enhancing the absorption of active ingredients in external preparations such as cosmetics. (See, for example, Patent Document 6, Patent Document 7, and Patent Document 8) However, 1) A skin external preparation in the form of an emulsifier in water containing a cross-linked methylpolysiloxane which may be partially modified. No skin external preparations having a composition containing 15) to 35% by weight of polyhydric alcohol and 3) 20 to 35% by weight of water are known, and by taking such a structure, an excellent oily component of the skin It has not been known at all that it exhibits occlusion and moisturization due to, and thus has a protective function that can resist environmental stress.

JP 2004-339113 A JP 2004-238297 A JP 2004-75619 A JP 2004-51637 A JP 2003-81868 A JP 2005-200333 A JP 2004-339106 A JP 2002-284624 A

  The present invention has been made under such circumstances, and an object of the present invention is to provide a skin external preparation having a protective function capable of resisting environmental stress.

In view of such a situation, the present inventors have sought for an external preparation for skin having a protective function capable of resisting environmental stress, and as a result of intensive research efforts, 1) may be partially modified. A skin external preparation in the form of an emulsifier in water containing a cross-linked methylpolysiloxane, such as 2) 15 to 35% by mass of a polyhydric alcohol and 3) 20 to 35% by mass of water. It has been found that it has excellent characteristics, and the present invention has been completed. That is, the present invention is as follows.
(1) 1) A skin external preparation in the form of an emulsifier in water containing a cross-linked methylpolysiloxane which may be partially modified, 2) 15 to 35% by mass of a polyhydric alcohol, and 3) 20 to 20 An external preparation for skin containing 35% by mass.
(2) The cross-linked methylpolysiloxane which may be partially modified is selected from cross-linked methylpolysiloxane, cross-linked phenylmethylpolysiloxane and polyether-modified methylpolysiloxane. The external preparation for skin according to (1).
(3) The external preparation for skin according to (1) or (2), wherein the content of the cross-linked methylpolysiloxane which may be partially modified is 1 to 10% by mass.
(4) The external preparation for skin according to any one of (1) to (3), wherein the polyhydric alcohol contains 18 to 25% by mass of glycerin.
(5) The skin external preparation according to any one of (1) to (4), further comprising 2 to 5% by mass of petrolatum.
(6) The hardness when the temperature is kept constant at 20 ° C. after the production is a penetration hardness value of 35 to 45 g (when an attachment of 8 mmφ is used and the load is 100 g), (1) (5) The external preparation for skin according to any one of (1) to (5).
(7) The external preparation for skin according to any one of (1) to (6), which is a cosmetic for occlusive and moisturizing with an oily component of the skin.

  ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation which has a protective function which can resist environmental stress can be provided.

(1) Crosslinked methylpolysiloxane which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing a crosslinkable methylpolysiloxane which may be partially modified. Here, the cross-linked type means a cross-linked structure in which a silicone chain and a silicone chain are connected by a carbon-carbon bond. Specifically, a silicone chain is constructed by polymerizing dimethyldimethoxysilane or dimethyldichlorosilane. For example, dimethylmethoxyvinylsilane, chlorodimethylvinylsilane, etc. may be copolymerized in the coexistence, and then vinyl groups may be polymerized to form a crosslinked structure. In addition, modification with a modifying group is a co-existence in which one of a methoxy group or a methyl group such as dimethyldimethoxysilane or dimethyldichlorosilane is substituted with a modifying group such as a polyoxyethylene group, a phenyl group or an amino group. And can be introduced by copolymerization. Specific examples of such a crosslinked methylpolysiloxane which may be partially modified include, for example, a crosslinked methylpolysiloxane ((dimethicone / vinyldimethicone) crosspolymer) and a crosslinked methylphenylpolysiloxane ((phenyl). (Methicone / vinyl dimethicone) crosspolymer), cross-linked polyether-modified methylpolysiloxane ((polyether-modified methicone / dimethicone / vinyl dimethicone) crosspolymer) and the like. These are all cosmetic raw materials, and some of them are already on the market. Such commercial products can be purchased and used. Examples of preferable commercially available products include “silicone KSG-16” (20% dimethicone solution of crosslinked methylpolysiloxane) and “silicone KSG-21” (crosslinked polyether-modified methylpolysiloxane) manufactured by Shin-Etsu Silicone Co., Ltd. it can. In the external preparation for skin of the present invention, such a component can be used to enhance the internal phase structure with a cross-linked structure of an oil-in-water emulsifier type in formulation and enhance the stability of the internal phase. It reduces the amount, suppresses the formation of a moisture permeable structure derived from the surfactant, and enhances the occlusion moisturizing effect. In order to express such an action, the above-mentioned partially modified cross-linked methylpolysiloxane may contain only one species, or may contain two or more species in combination. As its content, 1-10 mass% is preferable, and 2-5 mass% is especially preferable.

(2) Polyhydric alcohol which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is 15 to 35% by mass, more preferably 20 to 20% by mass of the total amount of polyhydric alcohol based on the total amount of external preparation for skin. 30% by mass is contained. The polyhydric alcohol can be used without particular limitation as long as it is used in a skin external preparation such as cosmetics. For example, 1,3-butanediol, glycerin, dipropylene glycol, diglycerin, Preferred examples include polyethylene glycol, isoprene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, neopentyl glycol and the like. These can contain only the seed | species, and can also contain it in combination of 2 or more type. This component improves the stability of the outer phase of the oil-in-water emulsifier type within this blending amount range, and stabilizes the emulsified state even if the total amount of surfactant is 4.5% by mass or less. Has an effect. For this reason, as described above, an excellent occlusion moisturizing effect can be realized. A particularly preferred form is a form containing 18 to 25% by mass, more preferably 19 to 23% by mass of glycerin in such polyhydric alcohol. By taking such a form, in addition to the occlusion effect, a moisturizing effect can be imparted to the decorative film, and thus an excellent occlusion moisturizing property can be realized.

(3) Water as an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing 20 to 35 mass%, more preferably 23 to 30 mass%, of water as an essential component. Water is indispensable for constituting an oil-in-water emulsifier form, and if the amount of water is excessive, the occlusion moisturizing effect is impaired, or the amount of surfactant for emulsification needs to be increased. There is a need to minimize the content, and the range is the content range.

(4) External preparation for skin of the present invention The external preparation for skin of the present invention contains the essential components and is in the form of an oil-in-water emulsifier. The oil-in-water emulsifier form embodies the occlusion moisturizing effect, and allows a water reservoir layer to be constructed in the epidermal tissue. As a result, a protective function capable of resisting excellent environmental stress can be imparted to the stratum corneum. Even in the case of water-in-oil emulsifiers and the like, the occlusion moisturizing effect can be realized, but it is difficult to form a moisture reservoir layer. In this sense, the oil-in-water emulsifier form is required. In addition, by emulsifying the surfactant with a low content of 4.5% by mass or less in a form in which the outer phase and the inner phase are strengthened by the combination of the essential components, the solid property is high in hardness but low in viscosity. The oil-in-water emulsion having a strong solid property has properties such as solidified water. For this reason, volatilization of moisture from the skin can be stopped in the form of a block of water. As a characteristic value of such physical properties, the hardness when the temperature is constant at 20 ° C. after manufacture is a penetration hardness value of 35 to 45 g (when an attachment of 8 mmφ is used and the load is 100 g). Preferred examples can be given.

  The skin external preparation of this invention can contain the arbitrary components normally used by skin external preparations, such as cosmetics, besides the said essential component. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oil such as beeswax, canola wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oils such as silicone oils that do not have a cross-linked structure such as modified polysiloxanes such as fluorine-modified polysiloxanes; anions such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkylsulfuric acid triethanolamine ether, etc. Surfactants; Cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-copolymers) Amphoteric surfactants such as coil-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), acylmethyl taurine; sorbitan Fatty acid esters (such as sorbitan monostearate, sorbitan sesquioleate), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE Lysine fatty acid esters (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE) Nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.) ), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid and sodium lactate; surface-treated mica, talc, caustic Powders such as phosphorus, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate; surface may be treated, bengara, yellow iron oxide, black iron oxide, oxidized Cobalt, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments; surface treated pearlescent agents such as titanium mica, fish phosphorous foil, bismuth oxychloride; red lacquered 202 No., Red 228, Red 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Organic pigments such as Blue No. 1, Green No. 201, Purple No. 201, Red No. 204; polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer Organic powders such as: para-aminobenzoic acid UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; sugar UV absorbers; UV absorbers such as 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole and 4-methoxy-4′-t-butyldibenzoylmethane; lower alcohols such as ethanol and isopropanol; vitamin A Or a derivative thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or a derivative thereof, vitamin B12, vitamin B15 or a derivative thereof, etc .; α-tocopherol, β-tocopherol, γ-tocopherol Vitamin E acetate such as vitamin E acetate, vitamin D, Glutamic H, pantothenic acid, pantethine, vitamins etc. pyrroloquinoline quinone and the like; and antibacterial agents such as phenoxyethanol preferred examples. Among these components, a particularly preferred form can be exemplified by a form containing petrolatum, and the content of petrolatum can be preferably exemplified by 2 to 5 mass%, more preferably 2.1 to 2.5 mass%. . Such a component works synergistically with the cross-linked silicone and has an excellent effect of suppressing the amount of water dissipation. All three types of cosmetics contain jojoba oil, rice germ oil and evening primrose oil. This is because the combination of the three types of oily components is highly compatible with the essential constituents of the three types of cosmetics, and by containing such components, the three-layer emollient film structure is firmly connected in the vertical direction. In order to achieve such a form, it is preferable that jojoba oil, rice germ oil and evening primrose oil contain 0.05 to 5% by mass of the same amount or the doubled amount of the smallest of these three components. In containing, it is preferable to contain in the form of a microemulsion. The external preparation for skin of the present invention can be produced by treating the above components according to a conventional method. However, in order to obtain a microemulsion, it is preferable to perform an extruder treatment or a microfluidizer treatment.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it is needless to say that the present invention is not limited to such examples.

According to the formulation shown below, cosmetic 1 as an external preparation for skin of the present invention was produced.
That is, components (a), (b) and (c) were heated to 80 ° C. and dissolved, and (i) was gradually added to emulsify, and (c) was further added, followed by stirring and cooling to prepare an intermediate work-in-process emulsion. This was passed twice with a microfluidizer to obtain a creamy (hardness 40 g (8 mmφ, load 100 g)) cosmetic 1.

(I)
Glycerin 20% by mass
1,3-butanediol 8% by mass
Carboxyvinyl polymer 0.3% by mass
Xanthan gum 0.1% by mass
Phenoxyethanol 0.5% by mass
24% by weight of water
(B)
Petrolatum 4% by mass
Jojoba oil 0.1% by mass
Rice germ oil 0.1% by mass
Evening primrose oil 0.1% by mass
(Dimethicone / Vinyl dimethicone) Cross polymer 2.5% by mass
(Crosslinked methylpolysiloxane; “KSG16”)
Dimethicone 7.5% by mass
Cyclomethicone 5% by mass
Glyceryl trioctanoate 16% by mass
Honey wax 3% by mass
PEG-25 stearate 1.5% by mass
Glyceryl monostearate 1.2% by mass
PEG-150 stearic acid 0.5 mass%
Sorbitan sesquistearate 1% by mass
(C)
Potassium hydroxide 0.1% by mass
10.5% by weight of water

  The effect of the cosmetic 1 which is the cosmetic of the present invention was reduced to 5% by mass of the glycerin in the comparative example 1 (hardness 29 g) in which the cross-linked methylpolysiloxane was replaced with dimethicone and the cosmetic 1 and was replaced with water. Comparative Example 2 (hardness 25 g) was prepared in the same manner, and together with these, changes in TEWL of skin damaged with a 5% aqueous solution of sodium lauryl sulfate were measured and examined. The damage was made by applying sodium lauryl sulfate for 3 hours. After pasting, the site was wiped with absorbent cotton impregnated with warm water, sodium lauryl sulfate was removed, and after standing for 10 minutes, TEWL was measured with a tevameter (manufactured by Integral Corporation). After sequentially treating with cosmetics, TEWL was measured again. After the measurement, the cosmetic was removed with a cleansing material and a face wash, and it was confirmed that the TEWL value had returned to its original value, and other cosmetics were similarly evaluated. The results are shown in Table 1. From this, it can be seen that the cosmetic 1 which is an external preparation for skin of the present invention has an excellent moisturizing effect, and thus has a low TEWL (transdermal water dispersion loss).

  Using the cosmetic 1, Comparative Example 1, and Comparative Example 2 described above, a trial test for two weeks was conducted with a person who had a bad skin condition and felt stress as a panelist. There were 12 people who were attracted by internal recruitment who had poor skin condition and felt stress, and these 12 people were divided into 3 groups. Group 1 received cosmetic 1; group 1 comparative example 1; group 1 comparative example 2 twice daily for two mornings and nights. Two weeks later, a questionnaire asked whether there was any improvement in skin condition and whether there was any change in psychological pressure due to stress. The results are shown in Table 2. It can be seen that the cosmetic of the present invention improves the skin condition and reduces the psychological pressure caused by stress.

  In the same manner as in cosmetic 1 of Example 1, cosmetic 2 (hardness 36 g), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. When this was evaluated with the sodium lauryl sulfate injury model, the control of 56 was reduced to 34 after treatment. It turns out that it is preferable to contain 18-25 mass% of glycerol from this.

(I)
Glycerin 15% by mass
1,3-butanediol 13% by mass
Carboxyvinyl polymer 0.3% by mass
Xanthan gum 0.1% by mass
Phenoxyethanol 0.5% by mass
24% by weight of water
(B)
Petrolatum 4% by mass
Jojoba oil 0.1% by mass
Rice germ oil 0.1% by mass
Evening primrose oil 0.1% by mass
(Dimethicone / Vinyl dimethicone) Cross polymer 2.5% by mass
(Crosslinked methylpolysiloxane; “KSG16”)
Dimethicone 7.5% by mass
Cyclomethicone 5% by mass
Glyceryl trioctanoate 16% by mass
Honey wax 3% by mass
PEG-25 stearate 1.5% by mass
Glyceryl monostearate 1.2% by mass
PEG-150 stearic acid 0.5 mass%
Sorbitan sesquistearate 1% by mass
(C)
Potassium hydroxide 0.1% by mass
10.5% by weight of water

  In the same manner as cosmetic 1 in Example 1, cosmetic 3 (hardness 36 g), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. When this was evaluated with the sodium lauryl sulfate injury model, the control was 56 and decreased to 25 after treatment. It can be seen that the same effect is achieved.

(I)
Glycerin 20% by mass
1,3-butanediol 8% by mass
Carboxyvinyl polymer 0.3% by mass
Xanthan gum 0.1% by mass
Phenoxyethanol 0.5% by mass
24% by weight of water
(B)
Petrolatum 4% by mass
Jojoba oil 0.1% by mass
Rice germ oil 0.1% by mass
Evening primrose oil 0.1% by mass
(Polyether-modified dimethicone / vinyl dimethicone) Crosspolymer 2.5% by mass
(Polyether-modified cross-linked methylpolysiloxane; “KSG21”)
Dimethicone 7.5% by mass
Cyclomethicone 5% by mass
Glyceryl trioctanoate 16% by mass
Honey wax 3% by mass
PEG-25 stearate 1.5% by mass
Glyceryl monostearate 1.2% by mass
PEG-150 stearic acid 0.5 mass%
Sorbitan sesquistearate 1% by mass
(C)
Potassium hydroxide 0.1% by mass
10.5% by weight of water

  In the same manner as cosmetic 1 in Example 1, cosmetic 4 (hardness 38 g), which is an external preparation for skin of the present invention, was prepared according to the formulation shown below. When this was evaluated with a sodium lauryl sulfate injury model, the control was 56 and decreased to 26 after treatment. It can be seen that the same effect is achieved.

(I)
Glycerin 20% by mass
1,3-butanediol 8% by mass
Carboxyvinyl polymer 0.3% by mass
Xanthan gum 0.1% by mass
Phenoxyethanol 0.5% by mass
24% by weight of water
(B)
Petrolatum 4% by mass
Jojoba oil 0.1% by mass
Rice germ oil 0.1% by mass
Evening primrose oil 0.1% by mass
(Phenylmethicone / vinyl dimethicone) Crosspolymer 2.5% by mass
(Crosslinked phenylmethylpolysiloxane)
Dimethicone 7.5% by mass
Cyclomethicone 5% by mass
Glyceryl trioctanoate 16% by mass
Honey wax 3% by mass
PEG-25 stearate 1.5% by mass
Glyceryl monostearate 1.2% by mass
PEG-150 stearic acid 0.5 mass%
Sorbitan sesquistearate 1% by mass
(C)
Potassium hydroxide 0.1% by mass
10.5% by weight of water

  The present invention can be applied to an external preparation for skin such as cosmetics.

Claims (7)

1) A skin external preparation in the form of an emulsifier in water containing a cross-linked methylpolysiloxane which may be partially modified, 2) 15 to 35% by weight of a polyhydric alcohol, and 3) 20 to 35% by weight of water. An external preparation for skin. The crosslinked methylpolysiloxane which may be partially modified is selected from crosslinked methylpolysiloxane, crosslinked phenylmethylpolysiloxane and polyether-modified methylpolysiloxane. Item 1. An external preparation for skin according to Item 1. The skin external preparation according to claim 1 or 2, wherein the content of the cross-linked methylpolysiloxane which may be partially modified is 1 to 10% by mass. The external preparation for skin according to any one of claims 1 to 3, wherein the polyhydric alcohol contains 18 to 25% by mass of glycerin. Furthermore, 2-5 mass% of petrolatum is contained, The skin external preparation in any one of Claims 1-4 characterized by the above-mentioned. The hardness when the temperature is kept constant at 20 ° C. after the production is a penetration hardness value of 35 to 45 g (when an attachment of 8 mmφ is used and the load is 100 g). The skin external preparation of Claim 1. The skin external preparation according to any one of claims 1 to 6, which is a cosmetic for moisturizing and occluding with an oily component of the skin.