JP2007153822A - Skin care preparation for dark circle - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To partly clear the mechanism of the generation of dark circles around the eye and provide a cosmetic product to ameliorate the dark circles. <P>SOLUTION: The skin care preparation to be applied mainly to the dent part under the eye contains 5-15 mass% ascorbic acid and/or its salt. The skin care preparation has uniformizing action on the skin thickness and the blood flow rate. The uniformizing action on the skin thickness and blood flow rate is recognized as the amelioration action on dark circles. The variations of the values are determined on an examinee and compared with average variations of a specimen group, and the examinee is selected as a proper person to test the preparation when the variations of the examinee are larger than the average variations. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin containing ascorbic acid and / or a salt thereof as an active ingredient.

  Bears are known to be produced by various factors, such as aging changes, pigmentation, blood flow delay, collagen fiber loss and structural changes. (For example, refer nonpatent literature 1) For this, administration of a whitening component, administration of a blood flow improvement component, enforcement of a treatment for improving blood flow, etc. are considered to be effective. However, it must be said that the details of the bear generation mechanism and the decisive mechanism of bear improvement are still unknown. (For example, see Patent Document 1 and Patent Document 2)

  Under such circumstances, ascorbic acid phosphates and / or salts thereof, ascorbic acid glycosides and / or salts thereof, etc., have been proposed as one means for improving bears. . (For example, refer to Patent Document 3 and Patent Document 4) In such a case, the concentration of ascorbic acid administered is several%, and hardly exceeds 5% by mass. As an effect of administration of high-concentration ascorbic acids, an improvement effect of acne is known (see, for example, Patent Document 5). However, in the administration of such high-concentration ascorbic acids, the skin thickness and blood flow rate are reduced. There is no known change, nor is the relationship between skin thickness, blood flow variation and bear formation directly known. Cosmetics that affect skin thickness are already known (see, for example, Patent Document 6, Patent Document 7, Patent Document 8, and Patent Document 9), but skin external preparations such as cosmetics that reduce the variation are completely known. It is not done.

JP 2004-51627 A Japanese translation of PCT publication No. 2002-542177 JP 2001-81022 A JP-T-2005-535677 JP 2005-132726 A JP 2005-528323 A JP 2005-503373 A JP-T-2004-538299 Special table 2003-512212 gazette

  The present invention has been made under such circumstances, and it is an object of the present invention to clarify a part of the mechanism of bear generation and to provide a cosmetic for improving bears.

In view of such a situation, the present inventors have clarified a part of the mechanism of bear development, and have sought for cosmetics for improving bears, and as a result of intensive research efforts, ascorbic acid and / or its salts. Was found to have such an action, and the present invention was completed. That is, the present invention is as follows.
(1) A skin external preparation containing 5 to 15% by mass of ascorbic acid and / or a salt thereof, which should be administered exclusively to the concave portion of the lower part of the eye.
(2) The external preparation for skin according to (1), which has an action of averaging skin thickness and blood flow.
(3) The skin external preparation described in (1) or (2), wherein the skin thickness and blood flow averaging function are recognized as an effect of improving “bears”.
(4) A sample group representing the population is selected in advance, the skin thickness and blood flow of the facial region in the sample group are measured at multiple points, and the individual variations are measured, and the skin thickness in the sample group is measured. The average thickness of blood flow and blood flow are determined, and the skin thickness and blood flow of the facial part of the person who belongs to the population and should be a user of cosmetics is concerned with multiple points. Measuring, obtaining the variation, comparing with the average variation in the sample population, and selecting the appropriate user as the user when the variation is larger than the average variation. The external preparation for skin according to any one of (1) to (3).
(5) The external preparation for skin according to (4), wherein the facial region is below the eyes.

  ADVANTAGE OF THE INVENTION According to this invention, the end of the bear generation | occurrence | production mechanism will become clear, and the cosmetics which improve a bear can be provided.

(1) Ascorbic acid and / or a salt thereof as an essential component of the skin external preparation of the present invention The skin external preparation of the present invention contains ascorbic acid and / or a salt thereof as an essential component. The content of ascorbic acid and / or a salt thereof in the external preparation for skin of the present invention is 5 to 15% by mass, more preferably 7 to 13% by mass, based on the total amount of external preparation for skin. This is because the characteristics of the external preparation for skin of the present invention should improve the bear under the eyes, and the active ingredient for the improvement is ascorbic acid and / or a salt thereof. This is because an acid and / or a salt thereof is necessary. As ascorbine's salt, it can be used without particular limitation as long as it is usually used in skin external preparations such as cosmetics, for example, alkali metal salts such as sodium salt and potassium salt, calcium and magnesium, etc. Preferable examples include alkaline earth metal salts, ammonium salts, organic amine salts such as triethylamine salts and triethanolamine salts, and basic amino acid salts such as lysine salts and alginates. Particularly preferred is the sodium salt. Various mechanisms have been proposed as a mechanism by which ascorbic acid and / or a salt thereof improve the bear under the eyes. However, the present inventors have found that the determination of hemoglobin in the bear depends on the measurement site. The value (substituting value for blood flow) and the variation (deviation) in skin thickness are large, and this optically feels dullness under the eyes, which is recognized as a bear. Ascorbic acid and / or a salt thereof acts to reduce such variation (deviation) and reduce the optical effect of forming dullness. Such an action is an action that is manifested only with ascorbic acid and / or its salt, and is an action that cannot be observed with ascorbic acid phosphate and / or its salt, ascorbic acid glycoside and / or its salt, and the like.

(2) External preparation for skin of the present invention The external preparation for skin of the present invention contains the essential components, and should be administered exclusively to the recessed portion of the lower part of the eye. In particular, it has an effect of improving a bear accompanied by an increase in blood flow variation and skin thickness variation among the bears generated in this portion. Therefore, in the use of the external preparation for skin of the present invention, it is preferable to select as a user after confirming that it is such a bear, and as a specific flow, a sample group representative of the population in advance is used. The skin thickness and blood flow of the facial part in the sample group are measured at multiple points, and the individual variations are measured to obtain the average variation in skin thickness and blood flow in the sample group. Measure the skin thickness and blood flow of the facial part of the person who should be a cosmetic user belonging to the population, and determine the variation, As compared with these average variations, when the variation is larger than the average variation, it can be exemplified that the user is appropriately selected. By administering the external preparation for skin of the present invention to such a bear, the above-mentioned variation is reduced, and thus the effect of improving the bear is expressed.

  The external preparation for skin of the present invention can be applied without particular limitation as long as it is administered externally to the skin. For example, cosmetics including quasi drugs, external preparations for skin, external preparations for skin, etc. are suitable. It can be illustrated. Moreover, the formulation form can also be applied without special limitation, and a lotion dosage form, an essence dosage form, an emulsion dosage form, a dispersion dosage form, etc. can be illustrated suitably.

  The external preparation for skin of the present invention can contain optional components usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oil such as beeswax, canola wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Linear polysiloxanes such as oxane and diphenylpolysiloxane; cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, Oil agents such as silicone oils such as modified polysiloxanes such as fluorine-modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfates; Cationic surfactants such as stearyltrimethylammonium, benzalkonium chloride, laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imida Zolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan) Monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid ester Tells (POE-glycerol monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl) Ethers, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), Nonionic surfactants such as sucrose fatty acid ester and alkyl glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene Polyhydric alcohols such as recall, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; sodium pyrrolidonecarboxylate Moisturizing ingredients such as lactic acid and sodium lactate; powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate, etc. whose surface may be treated Body, the surface may be treated, inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide; surface may be treated, mica Pearl agents such as titanium, fish phosphorus foil, bismuth oxychloride; red 202 which may be raked, red Color 228, Red 226, Yellow 4, Blue 404, Yellow 5, Red 505, Red 230, Red 223, Orange 201, Red 213, Yellow 204, Yellow 203, Blue 1 No., green 201, purple 201, red 204, etc .; organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; para-aminobenzoic acid UV absorbers; anthranils Acid UV absorbers; salicylic acid UV absorbers; cinnamic acid UV absorbers; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzo Ultraviolet absorbers such as triazole and 4-methoxy-4′-t-butyldibenzoylmethane; lower grades such as ethanol and isopropanol Alcohols: Proteins derived from collagen and hydrolysates thereof, silk proteins and hydrolysates thereof, cereal proteins such as wheat and hydrolysates thereof; vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate Vitamin B6 such as vitamin B6 dioctanoate, vitamin B2 or a derivative thereof, vitamin B12, vitamin B15 or a derivative thereof; vitamin E such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, Preferable examples include vitamins such as vitamin H, pantothenic acid, pantethine, pyrroloquinoline quinone, etc .; antibacterial agents such as phenoxyethanol; The external preparation for skin of the present invention can be produced by treating such essential components and optional components according to a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  According to the formulation shown in Table 1 below, cosmetic 1 (lotion), which is an external preparation for skin of the present invention, was produced. That is, the prescription ingredients were stirred and mixed, solubilized, and cosmetic 1 was obtained.

<Test Example 1>
The effect of cosmetic 1 was tested. In other words, the panel thicknesses collected at random were divided into two groups: those with conspicuous bears (Group 1) and those with inconspicuous bears (Group 2). Was measured by the following procedure. The measurement sites were 5 sites per person, the deviation for each individual was determined, and the average value of the deviation for each group and the deviation were determined. The results are shown in Table 2. From this, it can be seen that a person with conspicuous bears has a large deviation in both skin thickness and blood flow.
Skin thickness: An attachment coated with a medium gel was brought into close contact with the indentation under the eye, and a subcutaneous ultrasonic echo image was taken and measured from the ultrasonic image (see FIG. 1). The thickness of 5 parts of this image was measured, and the deviation was obtained from this.
Blood flow: according to the method of Takiwaki et al. (H. Takiwaki et al. Quantification of erythema and pigmentation using a videomicroscope and acomuter British Journal of Dermatology (1994) 131, 85-92) An image of the spot was taken, compared with an image of erythema caused by ultraviolet rays in advance, and an erythema index, which is a value converted to the degree of inflammation of erythema, was determined from its luminance configuration. The deviation of this erythema index was determined.

  As panelists for the test, 16 people were selected from the first group, and these 16 people were divided into two groups, group A and group B, and the cosmetic 1 was applied twice a day in the morning and evening. Then, Group B was similarly coated with Comparative Example 1 in which sodium ascorbate of cosmetic 1 was replaced with glucoside ascorbate. This work was continued for 6 months, and the deviation of skin thickness and blood flow was measured again in the same manner as the star and time, and the average value of the deviation and the deviation of each group were obtained. The results are shown in Table 3. From this, it can be seen that the cosmetic 1 which is an external preparation for skin of the present invention is excellent in the effect of reducing the deviation.

Images of the indentations under the eyes of the 16 people in groups A and B (at the start and at the end) were presented to five panelists for each group, and the ranking of the four groups of bears was ranked. The results were as follows. From this, it can be seen that cosmetic 1 which is an external preparation for skin of the present invention has an excellent bear improving effect.
Paneler 1: A (Start)> B (Start)> B (End) >> A (End)
Paneler 2: B (Start)> A (Start)> B (End) >> A (End)
Paneler 3: A (Start)> B (Start) = B (End) >> A (End)
Paneler 4: A (start) = B (start)> B (end) >> A (end)
Paneler 5: A (start) = B (start) = B (end) >> A (end)

  The present invention can be applied to skin external preparations such as cosmetics.

Claims (5)

A skin external preparation containing 5 to 15% by mass of ascorbic acid and / or a salt thereof, and to be administered exclusively to the lower recessed portion of the eye. The skin external preparation according to claim 1, which has an action of averaging skin thickness and blood flow. The skin external preparation according to claim 1, wherein the skin thickness and blood flow averaging action is recognized as a “bear” improving action. Select a sample group that represents the population in advance, measure multiple points of skin thickness and blood flow in the facial region of the sample group, measure the individual variations, and determine the skin thickness and blood flow in the sample group. Measure the skin thickness and blood flow of the facial part of the person who should be a user of the cosmetics belonging to the population and who is interested in the bear. The variation is obtained, compared with these average variations in the sample population, and when the variation is larger than the average variation, the user is appropriately selected as the user. The skin external preparation of any one of claim | item 1-3. The external preparation for skin according to claim 4, wherein the facial part is under the eyes.