JP5068090B2 - Emulsifier type skin external preparation - Google Patents

Description

The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin having an excellent moisturizing effect and thus an effect of improving wrinkles.

It is said that the decrease in the moisture retention ability in the skin impairs the barrier function of the skin, and at the same time changes the form of the skin and causes wrinkles and the like. For this reason, it has been desired to develop a technique for treating skin with reduced moisturizing ability using an external preparation for skin such as cosmetics and suppressing changes in skin morphology such as wrinkles. As a method for imparting moisture retention to the skin, skin treatment with a topical skin preparation containing a polyhydric alcohol having a glycerin skeleton, such as polyglycerin such as glycerin and diglycerin, is known (for example, (See Patent Document 1, Patent Document 2, and Patent Document 3), but by adding such ingredients, the moisturizing property is imparted to the skin external preparation, but until the skin shape change such as wrinkles is suppressed. It has not reached.

On the other hand, treatment with an external preparation for skin containing amino-modified silicone or the like is known as a means for suppressing a decrease in moisture retention related to wrinkles (see, for example, Patent Document 4 and Patent Document 5). However, even in such a method, the effect tends to reach its peak, and it is difficult to say that it is a sufficient response. This is presumably because even if the adhesion of the skin external preparation composition film to the skin can be improved by containing amino-modified silicone, the water retention of this film is not so much. There is no known technique for combining such an amino-modified silicone and polyglycerin into a skin external preparation, and it is not known at all that a strong moisturizing film is formed by such a combination.

Japanese Patent Application Laid-Open No. 2006-238221 JP 2006-8893 A JP-T-2006-508171 JP 2005-306831 A JP 2004-323401 A

This invention is made | formed under such a condition, and makes it a subject to provide the skin external preparation which is excellent in the moisturizing provision | providing force which improves a wrinkle.

In view of such circumstances, the present inventors have intensively researched and sought after for an external preparation for skin having excellent moisturizing ability enough to improve wrinkles. 1) Amino-modified silicone and 2) Such an action was recognized in the external preparation for skin containing polyglycerin, and the present invention was completed. That is, the present invention is as follows.
(1) A skin external preparation characterized by containing 1 ) 0.01 to 10% by mass of aminopropylmethylpolysiloxane and 2) 1 to 10% by mass of diglycerin .
(2), characterized in that an emulsifying dosage form, a skin external preparation as described in (1).
( 3 ) The external preparation for skin according to (1) or (2) , wherein the emulsifier form is an oil-in-water emulsifier form.
( 4 ) The skin external preparation according to any one of (1) to ( 3 ), further comprising an alkyl-modified carboxyvinyl polymer and / or a salt thereof.
( 5 ) The external preparation for skin according to any one of (1) to ( 4 ), further comprising ubidecarenone and / or α-lipoic acid.
( 6 ) The external preparation for skin according to ( 5 ), wherein the ubidecalenone and / or α-lipoic acid is contained in the form of a vesicle.
( 7 ) The external preparation for skin according to ( 6 ), wherein the vesicle contains hydrogenated phospholipid and phytosterol.

ADVANTAGE OF THE INVENTION According to this invention, the external preparation for skin which is excellent in the moisturizing provision power which can improve a wrinkle can be provided.

(1) Aminopropylmethylpolysiloxane which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing aminopropylmethylpolysiloxane as an essential component . The In-aminopropyl methyl polysiloxane, such as this, when producing the silicone by polymerization, may be contained three reactive monomers such as methyl trimethoxy siloxane, crosslinked polymeric such as vinyl dimethoxy methylsiloxane It is also possible to have a crosslinked structure by adding a monomer having the above group. Having such a cross-linked structure improves the moisture retention, so that it preferably has a cross-linked structure. Further, the average molecular weight is preferably 100,000 or more, and more preferably 500,000 or more. As such aminopropylmethylpolysiloxane , for example, “silicone KF8017” (crosslinked aminopropylmethylpolysiloxane; average molecular weight of 600,000 to 700,000) sold by Shin-Etsu Chemical Co., Ltd. can be particularly preferably exemplified. . Or mow-aminopropyl methyl polysiloxane also to be able to contain only species, it may also be contained in combination of two or more. Preferable content is 0.01-10 mass% in total, More preferably, it is 0.05-1 mass%. Such components form a moisturizing composition film having excellent adhesion to the skin together with polyglycerin described later. In the amount range, the above action is preferably expressed.

(2) Polyglycerin as an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing polyglycerin as an essential component. The polyglycerin referred to in the present invention means a generic name of compounds in which two or more glycerin is ether-bonded, and specifically, diglycerin, triglycerin, tetraglycerin, pentaglycerin, decaglycerin, and the like can be suitably exemplified and polymerized. A degree of 5 or less (2 to 5) is more preferred, among which diglycerin or triglycerin is more preferred, and diglycerin is particularly preferred. As the degree of polymerization increases, the moisture retention of polyglycerin itself increases, but the compatibility with other formulation components decreases, and the film moisture retention is determined as the sum, and this property is diglycerin or triglycerin. This is because the case is particularly favorable. Due to the moisturizing film effect of such a combination with aminopropylmethylpolysiloxane, the effect of improving fine lines and the like is exhibited by providing moisturizing properties. In order to exert such an action, the content of diglycerin is preferably 1 to 10% by mass, and more preferably 2 to 8% by mass. This is because if the amount is too small, the above-described effect may not be achieved, and if the amount is too large, the effect may reach a limit, and sticky properties or heavy spread may be exhibited.

(3) External preparation for skin of the present invention The external preparation for skin of the present invention contains the above essential components and is in the form of an emulsifier. The form of the emulsifier form may be either the water-in-oil emulsifier form or the oil-in-water emulsifier form, but the oil-in-water emulsifier form is particularly preferred. Here, the water-in-oil emulsifier form is a term collectively referred to as an emulsifier form having an oil phase in the outer phase, and may contain an aqueous phase in the inner phase or may have an emulsion such as an oil-in-water emulsion. You may do it. Similarly, the oil-in-water emulsifier form is a general term for an emulsion having an aqueous phase in the outer phase, and may have an oil phase in the inner phase or an emulsion such as a water-in-oil emulsion. good. As an emulsifier used for such emulsification, it is preferable to use an ether-based nonionic surfactant such as polyoxyethylene alkyl ether or polyoxybutylene polyglycerin alkyl ether. This is because by using such a surfactant, the total amount of the surfactant can be reduced, and the influence of the surfactant on the skin barrier function can be reduced. The total amount of the surfactant is preferably 1 to 4% by mass, more preferably 1.5 to 3% by mass with respect to the total amount of the external preparation for skin. In addition to the surfactants described above, non-surfactants that are usually used in skin preparations such as cosmetics can be contained. Furthermore, it is also preferable to contain an alkyl-modified carboxyvinyl polymer and / or a salt thereof in the sense of keeping the emulsified state stable. The preferable content of such components is 0.01 to 0.5 mass%, more preferably 0.05 to 0.3 mass%, based on the total amount of the external preparation for skin. Such a component is preferably contained also in that sense because it forms a composite film with the essential component aminopropylmethylpolysiloxane after administration to the skin and enhances the effect of aminopropylmethylpolysiloxane . Such alkyl-modified carboxyvinyl polymers include commercially available products, which can be purchased and used. Examples of preferable commercial products include “Carbopol 1382”, “Pemlen TR-1”, “Pemlen TR-2” and the like sold by Goodrich.

In order to further improve the function of the external preparation for skin of the present invention, which imparts moisture retention and improves wrinkles, it is also preferable for the external preparation for skin of the present invention to contain components that are effective in improving wrinkles. As such components, for example, α-lipoic acid and / or a salt thereof, ubidecalenone, raspberry (Rosaceae raspberry) fruit juice extract, soybean isoflavone and the like can be preferably exemplified. Components having a problem in stability such as α-lipoic acid and ubidecalenone are preferably processed and contained in vesicles with components such as phospholipid, phytosterol and ceramide. As the phospholipid used at this time, it is preferable to use a hydrogenated phospholipid such as hydrogenated lecithin because the stability is further improved. A particularly preferred vesicle is a vesicle having a composition of 0.5 to 2 parts by mass of phytosterol and 7 to 15 parts by mass of hydrogenated phospholipid with respect to 0.5 to 2 parts by mass of α-lipoic acid or ubidecarenone. The vesicle is preferably contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. In addition, it is preferable that the extract of raspberry juice is processed into a product containing 100 nM or more of raspberry ketone or its glycoside. The preferred content is preferably 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. Soy isoflavone is preferably in the form of glycoside and contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin.

The external preparation for skin of the present invention can contain, in addition to such components, optional components that are usually used in external preparations for skin. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, oil, wax, liquid wax, liquid paraffin, squalane, bean wax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba wax , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl Alcohol, behenyl alcohol, octyldodecanol, higher alcohol such as myristyl alcohol, cetostearyl alcohol, etc., cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate, dimethylpolysiloxane, methylphenylpoly Chain polysiloxanes such as Loxane, diphenylpolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc. Oils such as silicone oils such as modified polysiloxanes, fatty acid soaps (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkylethanol triethanolamine ether, stearyltrimethylammonium chloride, chloride Cationic surfactants such as benzalkonium and laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide) 1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan monostearate, sesquioxide) Sorbitan oleate, etc.), glycerin fatty acids (eg glyceryl monostearate), propylene glycol fatty acid esters (eg propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monoole) Acid, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin) Monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether, etc.), Pluronic type , POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl Nonionic surfactants such as glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, xylitol, propylene glycol, dipropylene glycol, diglycerin, iso Moisturizing of polyhydric alcohols such as lenglycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol, sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, etc. Classification, surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic acid (silica), aluminum oxide, barium sulfate, etc., surface treated Bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, mica titanium, fish phosphorus foil, bismuth oxychloride, etc. Pearl agents, which may be raked red 202, red 228, red 226, yellow 4, blue 404, yellow 5 No., Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, etc. , Polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomer, paraaminobenzoic acid UV absorber, anthranilic acid UV absorber, salicylic acid UV absorber, cinnamic acid UV absorber , UV absorbers such as benzophenone UV absorber, sugar UV absorber, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane s, ethanol, lower alcohols such as isopropanol, vitamin a or its derivatives, vitamin B ₆ hydrochloride, Vita Emissions B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ or derivatives thereof, vitamin B _12, vitamin B such as vitamin B ₁₅ or a derivative thereof, alpha-tocopherol, beta-tocopherol, .gamma.-tocopherol, vitamin E acetate Preferred examples include vitamins such as vitamin E, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone, and other antibacterial agents such as phenoxyethanol. The skin external preparation of this invention can be manufactured by processing the said essential component, a preferable component, and an arbitrary component in accordance with a conventional method. The external preparation for skin thus obtained is excellent in moisture retention and thus has the effect of improving wrinkles.

The skin external preparation of the present invention can be applied without particular limitation as long as it is externally applied to the skin, and examples thereof include cosmetics, skin external medicines, skin external goods, and the like. It is particularly preferable to apply it to a cosmetic because of its function. The cosmetic is not particularly limited, but is particularly preferably applied to skin care cosmetics, ultraviolet protective cosmetics, and the like.

Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

<Example 1>
According to the formulation shown in Table 1 below, a cosmetic in the form of an oil-in-water emulsifier, which is an external preparation for skin of the present invention, was produced. That is, the ingredients of (i), (ii) and (c) are heated to 80 ° C., (ii) is added to (ii) and neutralized, and then gradually added to the mixture under emulsification, emulsified, stirred and cooled, and an emulsion 1 in the form of an oil-in-water emulsifier. (Cosmetics) was obtained. In the same manner, Comparative Example 1 in which diglycerin was replaced with glycerin and Comparative Example 2 in which aminopropylmethylpolysiloxane was replaced with polyether-modified dimethicone (“silicone KF6017”) were also produced in the same manner.

<Manufacturing method of ubidecarenone-containing vesicle>
80% by mass of hydrogenated lecithin and 10% by mass of phytosterol are melted at 90 ° C., cooled to 60 ° C., uniformly dispersed by adding 10% by mass of ubidecarenone, rapidly cooled to 0 ° C., and vesicle mass This was pulverized with a jet mill to obtain vesicles having an average of 20 μm.

<Test Example 1>
For the emulsion 1, Comparative Example 1 and Comparative Example 2, the transdermal water transpiration (TEWL) was measured using Tewameter (Courage + Khazaka) using the tape-stripped region of the upper arm inner part. That is, after tape stripping, the sample was allowed to stand for 10 minutes, and then TEWL was measured. Then, 5 mg of the specimen was administered per 1000 mm ² , and allowed to stand for 10 minutes, and then TEWL was measured again. TEWL after treatment was divided by TEWL before treatment and multiplied by 100 to obtain TEWL suppression rate. The results are shown in Table 2. From this, it can be seen that the emulsion 1 which is an external preparation for skin of the present invention is excellent in the action of suppressing TEWL.

<Test Example 2>
The sample is administered to healthy skin at a dose of 5 mg per 1000 mm ² and left to stand for 10 minutes. A replica of this part is collected, and this is obliquely irradiated with light from 45 ° C., and the resulting shadow on the entire area of the irradiated surface. The percentage of the total area was measured and used as an index of skin irregularities. Untreated sites were also measured as subjects. The shadow produced by light irradiation from this angle is due to deep irregularities and is usually an indicator of fine lines. The results are shown in Table 3. From this, it can be seen that the external preparation for skin of the present invention has an excellent unevenness correction effect such as fine lines.

<Example 2>
By operating in the same manner as emulsion 1, emulsion 2 (cosmetics), which is an external preparation for skin according to the present invention whose prescription is shown in Table 4 below, was prepared. However, the TEWL suppression rate according to Test Example 1 was 33%, and the shadow percentage of the Test Example was 18%. It can be seen that alkyl-modified carboxyvinyl polymers and / or salts are preferred over carboxyvinyl polymers.

<Example 3>
By operating in the same manner as emulsion 1, emulsion 3 (cosmetics), which is an external preparation for skin according to the present invention whose formulation is shown in Table 5 below, was prepared. However, the TEWL suppression rate according to Test Example 1 was 42%, and the shadow percentage of the Test Example was 13%.

<Method for producing α-lipoic acid-containing vesicle>
80% by mass of hydrogenated lecithin and 10% by mass of phytosterol were melted at 90 ° C., cooled to 60 ° C., uniformly dispersed by adding 10% by mass of α-lipoic acid, and rapidly cooled to 0 ° C. A vesicle mass was prepared and pulverized with a jet mill to obtain vesicles having an average of 18 μm.

The present invention can be applied to external preparations for skin such as cosmetics.

Claims (7)

1) Aminopropylmethylpolysiloxane 0.01-10 mass% and 2) Diglycerin 1-10 mass% , The skin external preparation characterized by the above-mentioned. Characterized in that an emulsifier type external skin preparation according to claim 1. The external preparation for skin according to claim 1 or 2 , wherein the emulsifier form is an oil-in-water emulsifier form. The skin external preparation according to any one of claims 1 to 3, further comprising an alkyl-modified carboxyvinyl polymer and / or a salt thereof. Furthermore, ubidecarenone and / or (alpha) -lipoic acid are contained, The skin external preparation of any one of Claims 1-4 characterized by the above-mentioned. The external preparation for skin according to claim 5 , wherein the ubidecarenone and / or α-lipoic acid is contained in the form of a vesicle. The skin external preparation according to claim 6 , wherein the vesicle contains hydrogenated phospholipid and phytosterol.