JP5827079B2 - Powder-containing skin external preparation - Google Patents

Description

  The present invention relates to a skin external preparation, and more particularly to a skin external preparation suitable for cosmetics and skin external medicine.

  Hyaluronic acid and / or a salt thereof is widely used in skin external preparations such as cosmetics as a natural polymer compound having an excellent moisturizing action. Although hyaluronic acid and / or a salt thereof has an excellent moisturizing action, it also has an action of agglomerating powders and is difficult to use in the presence of powder. On the other hand, in powder-containing cosmetics, the powder absorbs sebum and absorbs moisture on the skin, so there is a feeling of dryness during use and the moisture in the skin itself is reduced. As a result, an improvement in moisture retention was desired. In addition to hyaluronic acid and / or a salt thereof, a polymer having a moisturizing property includes a polymer having a phosphorylcholine residue such as polymethacryloyloxyethyl phosphorylcholine, polyquaternium 51, or polyquaternium 61. These have structures similar to intercellular lipids, and are thought to strengthen the lipid bilayer structure and suppress transdermal water dispersion. Techniques for combining such components with hyaluronic acid and / or a salt thereof in a skin external preparation are already known (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3). However, in these combinations, not much combination effect is obtained, and other moisturizing components such as atelocollagen and polysaccharides have to be combined. Further, although a skin external preparation containing a powder coated with hyaluronic acid and / or a salt thereof and a polymer having a phosphorylcholine residue is already known (see, for example, Patent Document 4), these are simply combined. However, when powders obtained by other processing methods, such as hydrophobized powders, are present, powders with different surface characteristics will be present. In some cases, unevenness occurred. That is, there has been a demand for the development of a powder-containing skin external preparation that effectively uses the moisturizing action of hyaluronic acid and / or a salt thereof and a polymer having a phosphorylcholine residue and does not feel dry.

  On the other hand, an external preparation for skin containing hyaluronic acid and / or a salt thereof which may be hydrolyzed and a powder coated with a polymer or copolymer having phosphorylcholine as a residue is completely known. Absent.

JP 2010-120859 A JP 2010-90040 A JP 2007-161612 A JP 2008-94756 A

  It is an object of the present invention to provide a powder-containing external preparation for skin that effectively uses the moisturizing action of hyaluronic acid and / or a salt thereof and a polymer having a phosphorylcholine residue and does not feel dry.

In view of such circumstances, the present inventors have sought for a powder-containing skin external preparation that effectively uses the moisturizing action of a polymer having hyaluronic acid and / or a salt thereof and a phosphorylcholine residue, and does not feel dry. As a result of intensive research efforts, the skin external preparation in the form of an emulsifier has the following advantages: The skin external preparation (however, 1) containing the processed powder is excluded except that it is blended in the form of a coated powder. ) Has such characteristics, and the present invention has been completed. That is, the present invention is as follows.
<1> An emulsifier-type external preparation for skin comprising 1) a hydrolyzed hyaluronic acid and / or salt thereof, and 2) a powder whose surface is treated with a polymer or copolymer having a phosphorylcholine residue. Except for those in which the external preparation for skin (provided that 1) is blended in the form of a coated powder. )
<2> The skin external preparation according to <1>, wherein the polymer or copolymer having a phosphorylcholine residue is polyquaternium 51 or polyquaternium 61.
<3> The external preparation for skin according to <1> or <2>, wherein the powder serving as a powder base whose surface is treated with a polymer or copolymer having a phosphorylcholine residue is talc.
<4> The external preparation for skin according to any one of <1> to <3>, further comprising hydrophobized powder.
<5> The external preparation for skin according to <4>, wherein the hydrophobization treatment in the hydrophobization treatment powder is a metal soap coating treatment.
<6> The external preparation for skin according to any one of <1> to <5>, which is an oil-in-water emulsifier type.

  ADVANTAGE OF THE INVENTION According to this invention, the powder containing skin external preparation which does not have a dry feeling can be provided by utilizing effectively the moisturizing action of the polymer which has hyaluronic acid and / or its salt, and a phosphorylcholine residue.

<1> Hyaluronic acid and / or salt thereof, which is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention is in the form of an emulsifier and contains hyaluronic acid and / or a salt thereof. The hyaluronic acid may be partially hydrolyzed with hyaluronidase or the like. This is because the hyaluronic acid basically has the moisturizing action and fulfills its role in the external preparation for skin of the present invention. Examples of the salt of hyaluronic acid include alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as magnesium salt and calcium salt, organic amine salts such as triethanolamine salt and triethylammonium salt, ammonium salt, and the like. Suitable examples include basic amino acid salts such as lysine salt and arginine salt. In the present invention, the hydrolyzed hyaluronic acid and / or salt thereof exhibits excellent moisturizing properties and does not exhibit an undesirable phenomenon such as powder aggregation. Has the effect of suppressing the appearance of dryness during use. In order to exhibit such an action, the preferable content of hyaluronic acid and its salt which may be hydrolyzed is 0.0001 to 0.1% by mass, more preferably 0.0005 to 0.00. 001 mass%. If the amount is too large, the quality of the product may be impaired due to gelation. If the amount is too small, the moisturizing effect may not be obtained.

<2> Polymer and Copolymer Having Phosphorylcholine as Residue of External Preparation for Skin of the Present Invention The external preparation for skin of the present invention contains a polymer and copolymer having a residue of phosphorylcholine as a residue coated with powder. Required component. Preferred examples of the polymer or copolymer having phosphorylcholine as a residue include polymethacryloyloxyethyl phosphorylcholine, methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer (polyquaternium 51), methacryloyloxyethyl phosphorylcholine / stearyl methacrylate (polyquaternium 61), and the like. . These may be used alone or in combination of two or more. The coating may be carried out by mechanochemical, for example, by adjusting the aqueous solution of the polymer and the powder with a covol mill or the like, and then removing the water and pulverizing the residue. As the powder to be coated, those commonly used in cosmetics and the like are preferable, and among them, a plate-like powder is more preferable. Specific examples include talc, sericite, mica, titanium mica, and titanium sericite. The preferable mass ratio of the powder and the polymer or copolymer having the phosphorylcholine residue is preferably 999: 1 to 9: 1, more preferably 99: 1 to 95: 5. In the external preparation for skin of the present invention, such a powder serves as a base for expressing the physiological effect of phosphorylcholine residues, expresses a water retention function without competing with hyaluronic acids, and appears when a powder-containing external preparation for skin is used. It has the effect of suppressing the expression of dryness that tends to occur. The order to express such actions, preferably contains 0.1 to 10 wt% of the treated powder, and more preferably contains 1 to 5 mass%.

<3> External preparation for skin of the present invention The external preparation for skin of the present invention contains the above-mentioned components and is in an emulsifier form. As the emulsifier form, a water-in-oil emulsifier form in which the oil phase is present in the outermost layer or an oil-in-water emulsifier form in which the aqueous phase is present in the outermost layer can be suitably exemplified. Of these, the oil-in-water emulsifier form is particularly preferred. The water-in-oil emulsifier form is preferably an emulsification system using organically modified bentonite, and the oil-in-water emulsifier form is preferably an emulsifier form using fatty acid arginine soap as a surfactant.

In addition to the essential components, the external preparation for skin of the present invention can contain any components that are usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, palm oil, palm oil, liquid lanolin, hardened palm Oils, hydrogenated oils, moles, hydrogenated castor oils, beeswax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin, jojoba oil, waxes, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, Hydrocarbons such as petroleum jelly and microcrystalline wax, higher alcohols such as cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, etc. Cetyl sooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, Synthetic esters such as glycerin di-2-heptylundecanoate, glyceryl tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentane erythritol tetra-2-ethylhexanoate Oils, chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane , Cyclic polysiloxane such as dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, modified polysiloxane such as fluorine-modified polysiloxane, potassium lauryl sulfate, alkylsulfuric acid triethanolamine ether, etc. Anionic surfactants, cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide, imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyl) Roxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters ( Sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ether, POE sorbitan fatty acid ester (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoisostearate, etc.), POE Fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE Al Ruphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivative (POE castor oil) , POE hydrogenated castor oil, etc.), alkyl glucoside, (glycerin / oxybutylene) copolymer, nonionic surfactants such as alkyl ether, polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, Polyvalent such as propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol Moisturizing ingredients such as lucols, sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), oxidation Powders such as aluminum and barium sulfate, surface may be treated, inorganic pigments such as bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide, surface treated Pearl agents such as titanium mica, fish phosphorous foil, bismuth oxychloride, red 202, red 228, red 226, yellow 4, blue 404, yellow 5 No., Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Organic dyes such as Color No. 201 and Red No. 204, polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomer, paraaminobenzoic acid ultraviolet absorber, anthranilic acid ultraviolet absorber, Salicylic acid UV absorber, cinnamic acid UV absorber, benzophenone UV absorber, sugar UV absorber, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 4-methoxy-4 ' -t- butyl dibenzoyl ultraviolet absorber other than octocrylene ultraviolet absorbing agents such as methane, ethanol, lower alcohols such as isopropanol, vitamin a or its derivatives, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, Vitamin B ₆ dioctanoate, vitamin B ₂ or its derivatives, vitamin B ₁₂ , vitamin B ₁₅ such as vitamin B ₁₅ or its derivatives, α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone Preferred examples include vitamins such as antibacterial agents such as phenoxyethanol.

  In the external preparation for skin of the present invention, when the oil-in-water emulsifier form is selected, it is preferable to further include a highly hydrophilic nonionic surfactant among optional components, for example, the number of added moles of polyoxyethylene Preferred examples include polyoxyethylene alkyl (or alkenyl) ethers having a molecular weight of 20 or more and (glycerin / oxybutylene) copolymer alkyl (alkenyl) ethers. Such a highly hydrophilic nonionic surfactant can suppress the formation of a gel in a low temperature range and can enhance the stability on the low temperature side. Moreover, the spreadability at the time of use can be improved and a smooth feeling of use can be realized. In order to achieve such an effect, it is preferable to contain 0.1 to 1% by mass, more preferably 0.2 to 0.8% by mass, respectively.

  In addition, since the external preparation for skin of the present invention has a characteristic that suppresses the feeling of dryness during use while containing powder, the external preparation for skin of the present invention, other than the powder belonging to the essential components, It is preferable to contain a powder. As the powder other than the powder belonging to the essential component, a powder subjected to hydrophobic treatment is preferable, and a powder treated with metal soap is particularly preferable. The amount of the metal soap used for processing the powder is 0.1 to 20% by mass, more preferably 1 to 10% by mass, based on the total amount of the powder. The coating amount of the metal soap is particularly preferably 1 to 15% by mass with respect to the total amount of the powder.

  The external preparation for skin of the present invention can be applied to the cosmetics field or to the pharmaceutical field by containing an active ingredient. The skin external preparation of this invention can be manufactured by processing the said essential component and arbitrary component in accordance with a conventional method.

  Hereinafter, the present invention will be described in more detail with reference to examples.

<Production Example 1>
97 parts by mass of talc was placed in a pneumomerizer, and while blowing and mixing, while spraying 30 parts by mass of a 10% aqueous solution of polyquaternium 61, the mixture was blown at 40 ° C. After the spraying was completed, it was blown and dried. The obtained granules were pulverized with a hammer mixer equipped with a 1 mm herringbone, and then finished and pulverized with a hammer mill equipped with a 0.9 mm round hole screen to prepare polyquaternium 61-coated talc.

<Production Example 2>
97 parts by mass of fine particle titanium dioxide and 3 parts by mass of aluminum stearate were charged into a Henschel mixer and stirred at high speed, and then pulverized with a hammer mill equipped with a 2 mm herringbone screen to obtain metal soap-coated titanium dioxide.

<Production Example 3>
97 parts by mass of talc and 3 parts by mass of sodium hyaluronate were placed in a pneumomerizer, and blown and mixed while blowing 30 parts by mass of water while blowing at 40 ° C. The obtained granules were pulverized with a hammer mixer equipped with a 1 mm herringbone, and then finished and pulverized with a hammer mill equipped with a 0.9 mm round hole screen to prepare sodium hyaluronate-coated talc.

  According to the formulation shown in Table 1 below, a cosmetic that is an external preparation for skin of the present invention was produced. That is, the ingredients A and B are each heated to 80 ° C., the ingredient C is dispersed in the ingredient A, the ingredients B are gradually added under stirring, the mixture is cooled with stirring, and the cosmetic composition for external use in the skin of the present invention. 1 was obtained.

<Comparative Example 1>
Comparative Example 1 was prepared according to the formulation shown in Table 2 below as in Cosmetic 1.

<Comparative Example 2>
Comparative Example 2 was prepared according to the formulation shown in Table 3 below as in Cosmetic 1.

<Comparison test 1>
The cosmetics of cosmetic 1, comparative example 1, and comparative example 2 were comparatively evaluated. The evaluation items were dispersibility of powder dispersion under a microscope, observation of a transparent part sandwiched between two slide glasses, powder cohesiveness and gel unevenness, usability evaluated by three expert panelists (uniformity of paste) Nature, stretch, stop, moist feeling, dry feeling of the finish). The results are shown in Table 4. From this, it can be seen that the cosmetic 1 which is the external preparation for skin of the present invention has excellent cosmetic properties.

<Production Example 4>
The 10% polyquaternium 61 aqueous solution of Production Example 1 was changed to a 10% polyquaternium 51 aqueous solution and treated in the same manner to obtain polyquaternium 51-coated talc.

<Cosmetics 2>
By operating in the same manner as cosmetic 1, cosmetic 2 was obtained according to the formulation shown in Table 5 below.

<Comparative Example 3>
Comparative Example 3 was obtained in the same manner as in Cosmetic 1 and according to the formulation shown in Table 6 below.

<Comparative Example 4>
Comparative Example 4 was obtained in the same manner as in Cosmetic 1 and according to the formulation shown in Table 7 below.

<Comparison test 2>
As in Comparative Test 1, cosmetic 2, Comparative Example 3 and Comparative Example 4 were compared. The results are shown in Table 8. From this, it can be seen that the cosmetic 2 which is the external preparation for skin of the present invention has excellent cosmetic properties as the cosmetic 1 does. Also, the formulation was very stable and had good properties.

<Production Example 5>
The talc of Production Example 1 was replaced with sericite and treated in the same manner to obtain polyquaternium-coated sericite.

<Cosmetics 3>
According to the prescription shown in Table 9 below, the same operation as in the cosmetic 1 was performed to obtain a cosmetic 3. This product has good dispersibility, no powder agglomeration, no gel unevenness, uniform paste uniformity, good stretch, good stop, good moist feeling, after use There was no feeling of dryness.

  The present invention can be applied to skin external preparations such as cosmetics and pharmaceuticals.

Claims (6)

An emulsifier-type external preparation for skin containing 1) hyaluronic acid and / or a salt thereof which may be hydrolyzed, and 2) a powder whose surface is treated with a polymer or copolymer having a phosphorylcholine residue. This excludes those in which the external preparation for skin (however, 1) is blended in the form of a coated powder. ) The skin external preparation according to claim 1, wherein the polymer or copolymer having a phosphorylcholine residue is polyquaternium 51 or polyquaternium 61. The external preparation for skin according to claim 1 or 2, wherein the powder serving as a base of the powder whose surface is treated with a polymer or copolymer having a phosphorylcholine residue is talc. The external preparation for skin according to any one of claims 1 to 3, further comprising a hydrophobized powder. The external preparation for skin according to claim 4, wherein the hydrophobizing treatment in the hydrophobizing powder is a metal soap coating treatment. It is an oil-in-water emulsifier form, The skin external preparation in any one of Claims 1-5 characterized by the above-mentioned.