JP2008222653A - External preparation for skin with moisture retainability - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an external preparation for skin, excellent in a moisture retainability-imparting force in an extent for improving wrinkles. <P>SOLUTION: This external preparation for the skin is characterized by containing (1) amodimethicone and (2) sorbitol or maltitol in an emulsifier form. It is preferable that the emulsifier form is an oil-in-water type emulsifier form. It is further preferable that the external preparation for the skin contains an alkyl-modified carboxyvinyl polymer and/or its salt, and ubidecarenone. The ubidecarenone is preferably contained in the form of vesicle. It is further preferable that the vehicle contains a hydrogenated phospholipid and phytosterol in addition to the ubidecarenone. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin that is excellent in moisture retention and suitable for an external preparation for skin.

  It is said that the decrease in the moisture retention ability in the skin impairs the barrier function of the skin, and at the same time changes the form of the skin and causes wrinkles and the like. For this reason, it has been desired to develop a technique for treating skin with reduced moisturizing ability using an external preparation for skin such as cosmetics and suppressing changes in skin morphology such as wrinkles. As a means for suppressing such a decrease in moisture retention related to wrinkles, treatment with an external preparation for skin containing amino-modified silicone or the like is known (see, for example, Patent Document 1 and Patent Document 2). However, even in such a method, the effect tends to reach its peak, and it is difficult to say that it is a sufficient response. This is presumably because even if the adhesion of the skin external preparation composition film to the skin can be improved by containing amino-modified silicone, the water retention of this film is not so much.

  On the other hand, for sorbitol and maltitol, a technique for combining these sugar components and silicone into a skin external preparation is already known (see, for example, Patent Document 3). There is no known technique for containing an amino-modified silicone in combination. In addition, it has not been known at all that a skin external preparation excellent in moisturizing property enough to improve wrinkles can be obtained by combining such a sugar component and an amino-modified silicone into a skin external preparation. It was.

JP 2005-306831 A JP 2004-323401 A JP 2003-231627 A

  This invention is made | formed under such a condition, and makes it a subject to provide the skin external preparation which is excellent in the moisturizing provision | providing force which improves a wrinkle.

In view of such a situation, the present inventors have sought for an external preparation for skin having excellent moisturizing ability enough to improve wrinkles. As a result of earnest research efforts, 1) amodimethicone and 2) It has been found that an emulsifier-type external preparation for skin containing sorbitol or maltitol has such characteristics, and has completed the invention. That is, the present invention is as follows.
(1) A skin external preparation in the form of an emulsifier, characterized by containing 1) amodimethicone and 2) sorbitol or maltitol.
(2) The external preparation for skin according to (1), wherein the emulsifier form is an oil-in-water emulsifier form.
(3) The external preparation for skin according to (1) or (2), further comprising an alkyl-modified carboxyvinyl polymer and / or a salt thereof.
(4) The external preparation for skin according to any one of (1) to (3), further comprising ubidecarenone.
(5) The external preparation for skin according to (4), wherein the ubidecalenone is contained in the form of a vesicle.
(6) The external preparation for skin according to (4) or (6), wherein the vesicle contains hydrogenated phospholipid and phytosterol in addition to ubidecarenone.
(7) 1) amodimethicone, 2) sorbitol or maltitol, 3) alkyl-modified carboxyvinyl polymer and / or salt thereof, 4) ubidecalenone, 5) hydrogenated phospholipid, 6 (1) The external preparation for skin according to any one of (1) to (6), comprising phytosterol.

  It is possible to provide an external preparation for skin having excellent moisturizing ability enough to improve wrinkles.

(1) Amodimethicone which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention is characterized by containing amodimethicone as an essential component. Amodimethicone is also called an amino-modified silicone, specifically means aminoalkylmethylpolysiloxane, and the alkyl group in the aminoalkylmethylpolysiloxane is preferably an alkyl group having 1 to 4 carbon atoms, particularly preferably. Is an n-propyl group. In addition, in such amodimethicone, when a silicone is produced by polymerization, a trireactive monomer such as methyltrimethoxysiloxane is contained, or a crosslinkable group such as vinyldimethoxymethylsiloxane is included. It is also possible to provide a cross-linked structure by adding a monomer having a. Having such a cross-linked structure improves the moisture retention, so that it preferably has a cross-linked structure. Further, the average molecular weight is preferably 100,000 or more, and more preferably 500,000 or more. As such amodimethicone, for example, “silicone KF8017” (crosslinked aminopropylmethylpolysiloxane; average molecular weight of 600,000 to 700,000) sold by Shin-Etsu Chemical Co., Ltd. can be particularly preferably exemplified. In addition, “Silicone SF8457C” (aminoethylaminopropylethylsiloxane / dimethylsiloxane copolymer; manufactured by Toray Dow Corning), “Silicone SM8704C” (aminoethylaminopropylethylsiloxane / dimethylsiloxane copolymer; Toray (Made by Dow Corning) etc. can illustrate suitably. Such amodimethicone can contain only one species or a combination of two or more species. Preferable content is 0.01-10 mass% in total, More preferably, it is 0.05-1 mass%. Such components together with sorbitol or maltitol, which will be described later, form a moisturizing composition film having excellent adhesion to the skin. In the amount range, the above action is preferably expressed.

(2) Sugar component which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains sorbitol or maltitol as an essential component. Such a sugar component has an excellent effect of imparting moisture retention to the composition film formed by the amodimethicone. Such moisturizing properties cannot be obtained with other polyhydric alcohols such as glycerin and 1,3-butanediol, and the skin external preparation composition film containing such polyhydric alcohols is not described above. Even if it contains amodimethicone, which is an essential component, it often does not exhibit sufficient adhesion.

  Such sorbitol and / or maltitol can contain either one or both. The total content of such components is 0.1 to 10% by mass, and more preferably 0.5 to 5% by mass, based on the total amount of the external preparation for skin. The above characteristics are manifested within this amount range.

(3) The external preparation for skin of the present invention The external preparation for skin of the present invention contains the above essential components and is in the form of an emulsifier. The form of the emulsifier form may be either the water-in-oil emulsifier form or the oil-in-water emulsifier form, but the oil-in-water emulsifier form is particularly preferred. Here, the water-in-oil emulsifier form is a term collectively referred to as an emulsifier form having an oil phase in the outer phase, and may contain an aqueous phase in the inner phase or may have an emulsion such as an oil-in-water emulsion. You may do it. Similarly, the oil-in-water emulsifier form is a general term for an emulsion having an aqueous phase in the outer phase, and may have an oil phase in the inner phase or an emulsion such as a water-in-oil emulsion. good. As an emulsifier used for such emulsification, it is preferable to use an ether-based nonionic surfactant such as polyoxyethylene alkyl ether or polyoxybutylene polyglycerin alkyl ether. This is because by using such a surfactant, the total amount of the surfactant can be reduced, and the influence of the surfactant on the skin barrier function can be reduced. The total amount of the surfactant is preferably 1 to 4% by mass, more preferably 1.5 to 3% by mass with respect to the total amount of the external preparation for skin. In addition to the surfactants described above, non-surfactants that are usually used in skin preparations such as cosmetics can be contained. Furthermore, it is also preferable to contain an alkyl-modified carboxyvinyl polymer and / or a salt thereof in the sense of keeping the emulsified state stable. The preferable content of such components is 0.01 to 0.5 mass%, more preferably 0.05 to 0.3 mass%, based on the total amount of the external preparation for skin. Such a component is preferably contained also in that sense because it forms a composite film with the essential ingredient amodimethicone after administration to the skin and enhances the effect of amodimethicone. Such alkyl-modified carboxyvinyl polymers include commercially available products, which can be purchased and used. Examples of preferable commercial products include “Carbopol 1382”, “Pemlen TR-1”, “Pemlen TR-2” and the like sold by Goodrich.

  In order to further improve the function of the external preparation for skin of the present invention, which imparts moisture retention and improves wrinkles, it is also preferable for the external preparation for skin of the present invention to contain components that are effective in improving wrinkles. As such components, for example, α-lipoic acid and / or a salt thereof, ubidecalenone, raspberry (Rosaceae raspberry) fruit juice extract, soybean isoflavone and the like can be preferably exemplified. Components having a problem in stability such as α-lipoic acid and ubidecalenone are preferably processed and contained in vesicles with components such as phospholipid, phytosterol and ceramide. As the phospholipid used at this time, it is preferable to use a hydrogenated phospholipid such as hydrogenated lecithin because the stability is further improved. A particularly preferred vesicle is a vesicle having a composition of 0.5 to 2 parts by mass of phytosterol and 7 to 15 parts by mass of hydrogenated phospholipid with respect to 0.5 to 2 parts by mass of α-lipoic acid or ubidecarenone. The vesicle is preferably contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. In addition, it is preferable that the extract of raspberry juice is processed into a product containing 100 nM or more of raspberry ketone or its glycoside. The preferred content is preferably 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin. Soy isoflavone is preferably in the form of a glycoside and contained in an amount of 0.01 to 1% by mass, more preferably 0.05 to 0.5% by mass, based on the total amount of the external preparation for skin.

  The external preparation for skin of the present invention can contain, in addition to such components, optional components that are usually used in external preparations for skin. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil Oil, wax, oils such as beeswax, owl, hardened castor oil, beeswax, candelilla wax, carnauba wax, botarou, lanolin, reduced lanolin, hard lanolin, jojoba wax , Hydrocarbons such as microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl Higher alcohols such as alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, malic acid Diisostearyl, di-2-ethylhexanoic acid ethylene glycol, dicaprate neopentyl glycol, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoic acid glycerin, tri-2-ethylhexanoic acid trimethylolpropane, tri Synthetic ester oils such as trimethylolpropane isostearate and pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane, methylphenylpoly Chain polysiloxanes such as Loxane and diphenylpolysiloxane; Cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc. Oils such as silicone oils such as modified polysiloxanes; Anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate; stearyltrimethylammonium chloride, chloride Cationic surfactants such as benzalkonium and laurylamine oxide; imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide) 1-carboxyethyloxy disodium salt, etc.), betaine surfactants (alkyl betaine, amide betaine, sulfobetaine, etc.), and amphoteric surfactants such as acylmethyltaurine; sorbitan fatty acid esters (sorbitan monostearate, sesquioxide) Sorbitan oleate, etc.), glycerin fatty acids (eg glyceryl monostearate), propylene glycol fatty acid esters (eg propylene glycol monostearate), hardened castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monoole) Acid, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbitol monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin) Monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkyl phenyl ethers (POE nonylphenyl ether, etc.), Pluronic type , POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), sucrose fatty acid ester, alkyl Nonionic surfactants such as glucoside; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, xylitol, propylene glycol, dipropylene glycol, diglycerin, iso Polyhydric alcohols such as lenglycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; moisturizing composition such as sodium pyrrolidone carboxylate, lactic acid, sodium lactate Classification: The surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, etc .; surface treated Bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments; surface may be treated, mica titanium, fish phosphorus foil, bismuth oxychloride Pearl agents such as red 202, red 228, red 226, yellow 4, blue 404, yellow, which may be raked Organic dyes such as No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204 Organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, and cinnamic acid UV rays Benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane, etc. UV absorbers; lower alcohols such as ethanol and isopropanol; vitamin A or its derivatives, vitamin B6 salts Vitamin B such as salt, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B12, vitamin B15 or derivatives thereof; vitamins such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate Preferred examples include vitamins such as E, vitamin D, vitamin H, pantothenic acid, panthetin, and pyrroloquinoline quinone; and antibacterial agents such as phenoxyethanol. The skin external preparation of this invention can be manufactured by processing the said essential component, a preferable component, and an arbitrary component in accordance with a conventional method. The external preparation for skin thus obtained is excellent in moisture retention and thus has the effect of improving wrinkles.

  The skin external preparation of the present invention can be applied without particular limitation as long as it is externally applied to the skin, and examples thereof include cosmetics, skin external medicines, skin external goods, and the like. It is particularly preferable to apply it to a cosmetic because of its function. The cosmetic is not particularly limited, but is particularly preferably applied to skin care cosmetics, ultraviolet protective cosmetics, and the like.

  Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to such examples.

  According to the formulation shown below, an oil-in-water emulsifier type cosmetic that is an external preparation for skin of the present invention was produced. That is, the ingredients of (i), (ii) and (c) are heated to 80 ° C., (ii) is added to (ii) and neutralized, and then gradually added to the mixture under emulsification, emulsified, stirred and cooled, and an emulsion 1 in the form of an oil-in-water emulsifier. (Cosmetics) was obtained. In the same manner, Comparative Example 1 in which amodimethicone was replaced with polyether-modified silicone (“silicone KF6017”) and Comparative Example 2 in which sorbitol was replaced with glycerin were also produced in the same manner.

<Manufacturing method of ubidecarenone-containing vesicle>
80% by mass of hydrogenated lecithin and 10% by mass of phytosterol are melted at 90 ° C., cooled to 60 ° C., uniformly dispersed by adding 10% by mass of ubidecarenone, rapidly cooled to 0 ° C., and vesicle mass This was pulverized with a jet mill to obtain vesicles having an average of 20 μm.

<Test Example 1>
For the emulsion 1, Comparative Example 1 and Comparative Example 2, the transdermal water transpiration (TEWL) was measured using Tewameter (Courage + Khazaka) using the tape-stripped region of the upper arm inner part. That is, after tape stripping, the sample was allowed to stand for 10 minutes, and then TEWL was measured. The sample was administered at a dose of 5 mg per 1000 mm 2 and allowed to stand for 10 minutes, and then TEWL was measured again. TEWL after treatment was divided by TEWL before treatment and multiplied by 100 to obtain TEWL suppression rate. The results are shown in Table 2. From this, it can be seen that the emulsion 1 which is an external preparation for skin of the present invention is excellent in the action of suppressing TEWL.

<Test Example 2>
The sample is administered to healthy skin at a dose of 5 mg per 1000 mm2 and left to stand for 10 minutes. A replica of this part is collected, and this is irradiated obliquely at 45 ° C. The percentage of the total area was measured and used as an index of skin irregularities. Untreated sites were also measured as subjects. The shadow produced by light irradiation from this angle is due to deep irregularities, and is usually an indicator of fine lines. The results are shown in Table 3. From this, it can be seen that the external preparation for skin of the present invention has an excellent unevenness correction effect such as fine lines.

  By operating in the same manner as emulsion 1, emulsion 2 (cosmetics), which is an external preparation for skin of the present invention having the following formulation, was prepared. However, the TEWL suppression rate according to Test Example 1 was 33%, and the shadow percentage of the Test Example was 18%. It can be seen that alkyl-modified carboxyvinyl polymers and / or salts are preferred over carboxyvinyl polymers.

  By operating in the same manner as emulsion 1, emulsion 3 (cosmetics), which is a skin external preparation of the present invention, having the following formulation, was prepared. However, the TEWL suppression rate according to Test Example 1 was 38%, and the shadow percentage of the Test Example was 16%. It can be seen that maltitol can be used instead of sorbitol.

  By operating in the same manner as emulsion 1, emulsion 3 (cosmetics), which is a skin external preparation of the present invention, having the following formulation, was prepared. However, the TEWL suppression rate according to Test Example 1 was 42%, and the shadow percentage of the Test Example was 13%.

<Method for producing α-lipoic acid-containing vesicle>
80% by mass of hydrogenated lecithin and 10% by mass of phytosterol were melted at 90 ° C., cooled to 60 ° C., uniformly dispersed by adding 10% by mass of α-lipoic acid, and rapidly cooled to 0 ° C. A vesicle mass was prepared and pulverized with a jet mill to obtain vesicles having an average of 18 μm.

  The present invention can be applied to external preparations for skin such as cosmetics.

Claims (7)

An emulsifier type skin external preparation characterized by containing 1) amodimethicone and 2) sorbitol or maltitol. The skin external preparation according to claim 1, wherein the emulsifier form is an oil-in-water emulsifier form. The skin external preparation according to claim 1 or 2, further comprising an alkyl-modified carboxyvinyl polymer and / or a salt thereof. Furthermore, ubidecarenone is contained, The skin external preparation in any one of Claims 1-3 characterized by the above-mentioned. The external preparation for skin according to claim 4, wherein the ubidecalenone is contained in the form of a vesicle. The external preparation for skin according to claim 4 or 6, wherein the vesicle contains hydrogenated phospholipid and phytosterol in addition to ubidecarenone. 1) containing amodimethicone, 2) sorbitol or maltitol, 3) alkyl-modified carboxyvinyl polymer and / or salt thereof, 4) ubidecalenone, 5) hydrogenated phospholipid, 6) phytosterol, The skin external preparation of any one of Claims 1-6 characterized by containing.