JP2007099656A5 - - Google Patents
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- JP2007099656A5 JP2007099656A5 JP2005289905A JP2005289905A JP2007099656A5 JP 2007099656 A5 JP2007099656 A5 JP 2007099656A5 JP 2005289905 A JP2005289905 A JP 2005289905A JP 2005289905 A JP2005289905 A JP 2005289905A JP 2007099656 A5 JP2007099656 A5 JP 2007099656A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- liquid
- dimer
- cosmetic
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000002537 cosmetic Substances 0.000 claims description 42
- 239000007788 liquid Substances 0.000 claims description 39
- 239000000539 dimer Substances 0.000 claims description 37
- -1 acyl glutamate Chemical compound 0.000 claims description 33
- 239000002253 acid Substances 0.000 claims description 20
- 150000002009 diols Chemical class 0.000 claims description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 15
- 239000000194 fatty acid Substances 0.000 claims description 15
- 210000003491 Skin Anatomy 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 12
- 239000004530 micro-emulsion Substances 0.000 claims description 9
- DQAKJEWZWDQURW-UHFFFAOYSA-N 2-oxopyrrolidine-1-carboxylic acid Chemical compound OC(=O)N1CCCC1=O DQAKJEWZWDQURW-UHFFFAOYSA-N 0.000 claims description 8
- 229940079889 Pyrrolidonecarboxylic Acid Drugs 0.000 claims description 8
- 150000004665 fatty acids Chemical class 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 6
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 3
- 230000001502 supplementation Effects 0.000 claims description 3
- 230000014759 maintenance of location Effects 0.000 claims description 2
- FABAOYOFJNAVHB-KVVVOXFISA-N (Z)-octadec-9-enoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O FABAOYOFJNAVHB-KVVVOXFISA-N 0.000 claims 1
- 239000003921 oil Substances 0.000 description 13
- 235000019198 oils Nutrition 0.000 description 13
- 229920001296 polysiloxane Polymers 0.000 description 10
- 229940015001 Glycerin Drugs 0.000 description 8
- 235000011187 glycerol Nutrition 0.000 description 8
- 229960005150 glycerol Drugs 0.000 description 8
- 239000006096 absorbing agent Substances 0.000 description 7
- 239000004359 castor oil Substances 0.000 description 7
- 235000019438 castor oil Nutrition 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 230000003020 moisturizing Effects 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 229940119170 jojoba wax Drugs 0.000 description 5
- 229940089020 Evening primrose oil Drugs 0.000 description 4
- 239000004166 Lanolin Substances 0.000 description 4
- 229940039717 Lanolin Drugs 0.000 description 4
- OYHQOLUKZRVURQ-IXWMQOLASA-N Linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 4
- 240000007594 Oryza sativa Species 0.000 description 4
- 235000007164 Oryza sativa Nutrition 0.000 description 4
- 235000008524 evening primrose extract Nutrition 0.000 description 4
- 239000010475 evening primrose oil Substances 0.000 description 4
- 235000019388 lanolin Nutrition 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 235000009566 rice Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N Stearic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Substances CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 2
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L Barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N Behenic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- UNXHWFMMPAWVPI-QWWZWVQMSA-N D-Threitol Natural products OC[C@@H](O)[C@H](O)CO UNXHWFMMPAWVPI-QWWZWVQMSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- 229940009714 Erythritol Drugs 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N Erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 229940049906 Glutamate Drugs 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N Lauric acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N Oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N Palmitic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N Salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N Squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Trimethylglycine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000003247 decreasing Effects 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- QUEDXNHFTDJVIY-WENCSYSZSA-N gamma-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@](CCC[C@@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-WENCSYSZSA-N 0.000 description 2
- 230000001771 impaired Effects 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 235000020778 linoleic acid Nutrition 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N β-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- YPXOPAFVVHXQDP-ZZEZOPTASA-N (1Z)-1-[(2,4-dimethylphenyl)hydrazinylidene]naphthalen-2-one Chemical compound CC1=CC(C)=CC=C1N\N=C/1C2=CC=CC=C2C=CC\1=O YPXOPAFVVHXQDP-ZZEZOPTASA-N 0.000 description 1
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol;(Z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- JXNPEDYJTDQORS-AVQMFFATSA-N (9E,12E)-octadeca-9,12-dien-1-ol Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCO JXNPEDYJTDQORS-AVQMFFATSA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N 1-Tetradecanol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 1
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 1
- RKJGFHYCZPZJPE-UHFFFAOYSA-N 2,2-bis(16-methylheptadecanoyloxymethyl)butyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C RKJGFHYCZPZJPE-UHFFFAOYSA-N 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N 2-Imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N 2-Pyrrolidone Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- NCLNAHJFXIKYBY-UHFFFAOYSA-N 2-hexyldecyl 16-methylheptadecanoate Chemical compound CCCCCCCCC(CCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C NCLNAHJFXIKYBY-UHFFFAOYSA-N 0.000 description 1
- MUHFRORXWCGZGE-KTKRTIGZSA-N 2-hydroxyethyl (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCCO MUHFRORXWCGZGE-KTKRTIGZSA-N 0.000 description 1
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-hydroxypropyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N 3-(2,3-dihydroxypropoxy)propane-1,2-diol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-Aminobenzoic acid Chemical class NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- BGBDMEPBLWJCHI-UHFFFAOYSA-N 5-methyl-2-[[4-(4-methyl-2-sulfoanilino)-9,10-dioxoanthracen-1-yl]amino]benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC(C)=CC=C1NC(C=1C(=O)C2=CC=CC=C2C(=O)C=11)=CC=C1NC1=CC=C(C)C=C1S(O)(=O)=O BGBDMEPBLWJCHI-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N Aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N Anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 229960000686 Benzalkonium Chloride Drugs 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N Benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- GLQBXSIPUULYOG-UHFFFAOYSA-M Bismuth oxychloride Chemical compound Cl[Bi]=O GLQBXSIPUULYOG-UHFFFAOYSA-M 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N Bute hydrocarbon Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
- 229960003563 Calcium Carbonate Drugs 0.000 description 1
- 229940073532 Candelilla Wax Drugs 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N Cetyl alcohol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- LBFUKZWYPLNNJC-UHFFFAOYSA-N Cobalt(II,III) oxide Chemical compound [Co]=O.O=[Co]O[Co]=O LBFUKZWYPLNNJC-UHFFFAOYSA-N 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-α-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 229940105990 DIGLYCERIN Drugs 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- ZDQWESQEGGJUCH-UHFFFAOYSA-N Diisopropyl adipate Chemical compound CC(C)OC(=O)CCCCC(=O)OC(C)C ZDQWESQEGGJUCH-UHFFFAOYSA-N 0.000 description 1
- VJZWIFWPGRIJSN-XRHABHTOSA-N Dilinoleic acid Chemical class CCCCC\C=C/C\C=C/CCCCCCCC(O)=O.CCCCC\C=C/C\C=C/CCCCCCCC(O)=O VJZWIFWPGRIJSN-XRHABHTOSA-N 0.000 description 1
- VJHINFRRDQUWOJ-UHFFFAOYSA-N Dioctyl sebacate Chemical compound CCCCC(CC)COC(=O)CCCCCCCCC(=O)OCC(CC)CCCC VJHINFRRDQUWOJ-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N Dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- NOPFSRXAKWQILS-UHFFFAOYSA-N Docosanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 1
- 229960002989 Glutamic Acid Drugs 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N Hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl myristate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
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- 235000021360 Myristic acid Nutrition 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 229940116985 POTASSIUM LAURYL SULFATE Drugs 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- ZQTHOIGMSJMBLM-BUJSFMDZSA-N Pangamic acid Chemical compound CN(C)CC(=O)OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O ZQTHOIGMSJMBLM-BUJSFMDZSA-N 0.000 description 1
- 229940055726 Pantothenic Acid Drugs 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229940066842 Petrolatum Drugs 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N Phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 229960005323 Phenoxyethanol Drugs 0.000 description 1
- 239000004698 Polyethylene (PE) Substances 0.000 description 1
- ONQDVAFWWYYXHM-UHFFFAOYSA-M Potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 1
- MMXZSJMASHPLLR-UHFFFAOYSA-N Pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
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- 206010039203 Road traffic accident Diseases 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N Silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N Simethicone Chemical group C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 229940005581 Sodium Lactate Drugs 0.000 description 1
- 229940045870 Sodium Palmitate Drugs 0.000 description 1
- NGSFWBMYFKHRBD-UHFFFAOYSA-M Sodium lactate Chemical compound [Na+].CC(O)C([O-])=O NGSFWBMYFKHRBD-UHFFFAOYSA-M 0.000 description 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M Sodium laurate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 1
- 229940082004 Sodium laurate Drugs 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 229960005078 Sorbitan sesquioleate Drugs 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 1
- YXHBBEQKMVAJOH-GLCFPVLVSA-K Tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 YXHBBEQKMVAJOH-GLCFPVLVSA-K 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N TiO Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
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Description
本発明は、液状化粧料に関し、更に詳細には、保湿用の液状化粧料に関する。
The present invention relates to a liquid cosmetic, and more particularly to a liquid cosmetic for moisturizing.
現代は過剰なストレスの時代と言われており、景気の低迷などの社会状況の影響もあり
、過剰に負荷されたストレスから自殺する人の数は、既に交通事故で死亡する人の数を上回っている。この様な過負荷ストレスは、肌の状態にも影響を及ぼすことが知られており、かかる皮膚機能の損失を、ストレスを緩和することにより改善するための種々の有効成分が開発されている(例えば、特許文献1、特許文献2、特許文献3、特許文献4、特許文献5を参照)。しかしながら、この様な成分のみでは、実際に損なわれた機能が回復するまでは、皮膚の状態は損傷されたままの状態であり、刺激による炎症反応を起こしやすく、これが改悪原因ともなるので、その効果を奏するまでにかなりの時間が必要であった。その意味で、前記の対処では十分とは言い難い面が存した。
Modern times are said to be an era of excessive stress, and due to the impact of social conditions such as the economic downturn, the number of people who commit suicide from excessive stress exceeds the number of people who have already died in traffic accidents. ing. Such overload stress, in skin condition and it is known to affect, such a loss of skin functions, that have different active ingredients have been developed to improve by relaxing stress ( For example, see Patent Document 1, Patent Document 2, Patent Document 3, Patent Document 4, and Patent Document 5. ) However, with such ingredients alone, the skin condition remains damaged until the actually impaired function is restored, and it is likely to cause an inflammatory response due to irritation, which can also cause deterioration. It took a considerable amount of time to achieve the effect. In that sense , it was difficult to say that the above measures were sufficient.
一方、ダイマー酸とダイマージオールとのエステル、N−アシルグルタミン酸のジエステル、(ピロリドンカルボン酸/脂肪酸)グリセリルは何れも化粧料の原料であり、このものを化粧料に配合する技術は既に知られている(例えば、特許文献6、特許文献7、特許文献8を参照)。しかしながら、これらを含有するマイクロエマルション剤形の粘度100〜4000mPsの液状化粧料は全く知られていないし、その様な液状化粧料が環境ストレスの過負荷による皮膚の保湿機能の低下を補完する為に有用であることも全く知られていない。
On the other hand, esters of dimer acid and dimer diol, diesters of N- acyl glutamate, a raw material (pyrrolidone carboxylic acid / fatty acid) glycerin Le Any cosmetic art of compounding this thing in cosmetics is already known Tei Ru (e.g., refer to Patent Document 6, Patent Document 7, Patent Document 8). However, liquid cosmetics having a viscosity of 100 to 4000 mPs in microemulsion dosage forms containing these are not known at all, and such liquid cosmetics are intended to complement the reduction of skin moisturizing function due to overload of environmental stress. Nor is it known to be useful at all.
この様な状況に鑑みて、本発明者らは、環境ストレスの過負荷による皮膚の保湿機能の低下を補完する為に有用な化粧料を求めて、鋭意研究努力を重ねた結果、ダイマー酸とダイマージオールとのエステル、N−アシルグルタミン酸のジエステル乃至は(ピロリドンカルボン酸/脂肪酸)グリセリルを含有する、マイクロエマルション剤形の粘度100〜4000mPsの液状化粧料がその様な特性を有していることを見出し、発明を完成させるに至った。即ち、本発明は以下に示すとおりである。
(1)ダイマー酸とダイマージオールとのエステル、N−アシルグルタミン酸のジエステル、(ピロリドンカルボン酸/脂肪酸)グリセリルから選ばれる少なくとも1種以上の抱水性の液状油性成分を含有し、マイクロエマルション剤形の、粘度100〜4000mPsの液状化粧料。
(2)前記抱水性の液状油性成分として、ダイマー酸とダイマージオールとのエステルとピロリドンカルボン酸/オレイン酸グリセリルとをともに含むことを特徴とする、(1)に記載の液状化粧料。
(3)前記抱水性の液状油性成分の含有量が、化粧料全量に対して、総量で0.005〜1質量%であることを特徴とする(1)又は(2)に記載の液状化粧料。
(4)環境ストレスの過負荷による皮膚の保湿機能の低下を補完する為の化粧料であることを特徴とする、(1)〜(3)何れか1項に記載の液状化粧料。
In view of such a situation, the present inventors sought diligent acid and dimer acid as a result of earnest research efforts in search of a cosmetic useful for supplementing the decrease in skin moisturizing function due to overload of environmental stress. esters of dimer diol, N- diesters or acyl glutamic acid containing (pyrrolidone carboxylic acid / fatty acid) glycerin Le, liquid cosmetic of viscosity of the microemulsion dosage form 100~4000mPs has a such characteristic I found out and came to complete the invention. That is, the present invention is as follows.
(1) ester of dimer acid and dimer diol, N- diesters acyl glutamate, containing at least one or more kinds of water-holding property of the liquid oil component selected from (pyrrolidone carboxylic acid / fatty acid) glyceryl, a microemulsion dosage form Liquid cosmetics with a viscosity of 100 to 4000 mPs.
(2) The liquid cosmetic composition according to (1), characterized in that it includes both a dimer acid and an ester of dimer diol and pyrrolidone carboxylic acid / glyceryl oleate as the water-soluble liquid oil component.
(3) The liquid makeup according to (1) or (2), wherein the content of the water-containing liquid oily component is 0.005 to 1% by mass in total with respect to the total amount of the cosmetic. Fee.
(4) The liquid cosmetic according to any one of (1) to (3), which is a cosmetic for supplementing a decrease in the moisture retention function of the skin due to an overload of environmental stress.
本発明の液状化粧料は、抱水性の液状油性成分であるダイマー酸とダイマージオールとのエステル、N−アシルグルタミン酸のジエステル、(ピロリドンカルボン酸/脂肪酸)グリセリルの少なくとも1種以上を含有し、マイクロエマルション剤形であり、粘度が100〜4000mPsであることを特徴とする。
Liquid cosmetic of the present invention contains an ester of dimer acid and dimer diol is a liquid oil component water-holding property, diesters of N- acylglutamate, more at least one (pyrrolidone carboxylic acid / fatty acid) glyceryl, micro It is an emulsion dosage form and has a viscosity of 100 to 4000 m Ps .
ここで、ダイマー酸とダイマージオールとのエステルを構成する、ダイマー酸は不飽和脂肪酸の分子間重合反応によって得られる既知の二塩基酸であり、かかるダイマー酸には、例えばユニケマ社製のPRIPOL1006、同1009、同1015、同1025等の様に市販されているものも存する。本発明の液状化粧料の必須成分である、ダイマー酸とダイマージオールとのエステルを構成する、この様なダイマー酸ユニットの内で特に好ましいものは、リノール酸をダイマー化したダイマージリノール酸である。
Here, the dimer acid constituting the ester of dimer acid and dimer diol is a known dibasic acid obtained by an intermolecular polymerization reaction of an unsaturated fatty acid. For such dimer acid, for example, PRIPOL 1006 manufactured by Unikema Corporation, There are also commercially available products such as 1009, 1015, and 1025. Among such dimer acid units constituting the ester of dimer acid and dimer diol, which is an essential component of the liquid cosmetic composition of the present invention, particularly preferred is dimerlinoleic acid obtained by dimerizing linoleic acid. .
ダイマー酸とダイマージオールとのエステルを構成する、もう一方のダイマージオールは、ダイマー酸に、接触還元触媒の存在下、水素添加を行い、カルボキシル基を水酸基に変換した化合物であり、このようなダイマージオールとしては、ユニケマ社のPRIPOL2033等の様な市販品も存する。特に好ましいダイマージオールとしては前記ダイマージリノール酸を還元して得られるダイマージリノレイルアルコールである。
The other dimer diol constituting the ester of dimer acid and dimer diol is a compound obtained by hydrogenating dimer acid in the presence of a catalytic reduction catalyst to convert a carboxyl group into a hydroxyl group. As the diol, there are commercially available products such as PRIPOL 2033 of Unikema Corporation. A particularly preferred dimer diol is dimer linoleyl alcohol obtained by reducing the dimer linoleic acid.
前記ダイマー酸と前記ダイマージオールとを常法に従いエステル化することにより、本発明の液状化粧料の必須成分である、ダイマー酸とダイマージオールのエステルは製造することが出来る。この様なダイマー酸とダイマージオールとのエステルの中で特に好ましいものは、ダイマージリノール酸ダイマージリノレイルであり、この様な構造のものには既に市販品が存し、かかる市販品を購入して利用することも出来る。ダイマージリノール酸ダイマージリノレイルの市販品としては、日本精化株式会社製の「ラスプランDD−DA7」が好ましく例示できる。
By esterifying the dimer acid and the dimer diol according to a conventional method, an ester of dimer acid and dimer diol, which is an essential component of the liquid cosmetic of the present invention, can be produced. Among such esters of dimer acid and dimer diol, dimer linoleic acid dimer linoleyl is particularly preferable, and such a structure already has a commercially available product. It can also be used. As a commercial item of dimer dilinoleic acid dimer dilinoleil, “Rusplan DD-DA7” manufactured by Nippon Seika Co., Ltd. can be preferably exemplified.
本発明の液状化粧料に於いて、かかる抱水性の液状油性成分は唯一種を含有することも出来るし、二種以上を組み合わせて含有することも出来る。かかる成分は肌内部に「うるおいを抱える膜」を形成させる効果を有する。この様な効果を奏するためには、かかる成分の量は、化粧料全量に対して、総量で0.005〜1質量%であり、より好ましくは0.01〜1質量%である。更に、肌内部に到達する必要性もあることから、製剤設計としては、肌内部に浸透しやすい剤形とすることが好ましく、具体的には、粘度1000〜4000mPsのマイクロエマルション製剤とすることが挙げられる。ここで、マイクロエマルション製剤としては、ミセルの平均粒子径が1μm以下の半透明を呈する形態のミセルの存在形態を意味する。この様なマイクロエマルションは、予め、油相と水相の一部をマイクロフルイダイザーや、エクストルーダー、高圧ホモジナイザーなどの高負荷混合装置で混合することにより製造することが出来る。高率から勘案すれば、マイクロフルイダイザーを用いてマイクロエマルションを製造することが特に好ましい。
In the liquid cosmetic composition of the present invention, the water-containing liquid oily component can contain only one species, or a combination of two or more species. Such components have the effect of forming a “moisturizing film” inside the skin. In order to achieve such an effect, the amount of the component is 0.005 to 1% by mass, more preferably 0.01 to 1% by mass, based on the total amount of the cosmetic. Furthermore, since it is necessary to reach the inside of the skin, the formulation design is preferably a dosage form that easily penetrates into the skin, and specifically, a microemulsion formulation having a viscosity of 1000 to 4000 mPs. Can be mentioned. Here, as a microemulsion formulation, the presence form of the micelle of the form which exhibits the translucent form whose average particle diameter of a micelle is 1 micrometer or less is meant. Such a microemulsion can be produced in advance by mixing a part of the oil phase and the aqueous phase with a high-load mixing device such as a microfluidizer, an extruder, or a high-pressure homogenizer. Considering the high rate, it is particularly preferable to produce a microemulsion using a microfluidizer.
本発明の液状化粧料に於いては、本発明の効果を損なわない範囲において、通常化粧料で使用される任意成分を含有することが出来る。この様な任意成分としては、例えば、マカデミアナッツ油、アボガド油、トウモロコシ油、オリーブ油、ナタネ油、ゴマ油、ヒマシ油、サフラワー油、綿実油、ホホバ油、ヤシ油、パーム油、米胚芽油、月見草油、液状ラノリン、硬化ヤシ油、硬化油、モクロウ、硬化ヒマシ油、ミツロウ、キャンデリラロウ、カルナウバロウ、イボタロウ、ラノリン、還元ラノリン、硬質ラノリン、ホホバロウ等のオイル、ワックス類;流動パラフィン、スクワラン、プリスタン、オゾケライト、パラフィン、セレシン、ワセリン、マイクロクリスタリンワックス等の炭化水素類;オレイン酸、イソステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘン酸、ウンデシレン酸等の高級脂肪酸類;セチルアルコール、ステアリルアルコール、イソステアリルアルコール、ベヘニルアルコール、オクチルドデカノール、ミリスチルアルコール、セトステアリルアルコール等の高級アルコール等;イソオクタン酸セチル、ミリスチン酸イソプロピル、イソステアリン酸ヘキシルデシル、アジピン酸ジイソプロピル、セバチン酸ジ−2−エチルヘキシル、乳酸セチル、リンゴ酸ジイソステアリル、ジ−2−エチルヘキサン酸エチレングリコール、ジカプリン酸ネオペンチルグリコール、ジ−2−ヘプチルウンデカン酸グリセリン、トリ−2−エチルヘキサン酸グリセリン、トリ−2−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−2−エチルヘキサン酸ペンタンエリトリット等の合成エステル油類;ジメチルポリシロキサン、メチルフェニルポリシロキサン、ジフェニルポリシロキサン等の鎖状ポリシロキサン;オクタメチルシクロテトラシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサンシロキサン等の環状ポリシロキサン;アミノ変性ポリシロキサン、ポリエーテル変性ポリシロキサン、アルキル変性ポリシロキサン、フッ素変性ポリシロキサン等の変性ポリシロキサン等のシリコーン油等の油剤類;脂肪酸セッケン(ラウリン酸ナトリウム、パルミチン酸ナトリウム等)、ラウリル硫酸カリウム、アルキル硫酸トリエタノールアミンエーテル等のアニオン界面活性剤類;塩化ステアリルトリメチルアンモニウム、塩化ベンザルコニウム、ラウリルアミンオキサイド等のカチオン界面活性剤類;イミダゾリン系両性界面活性剤(2−ココイル−2−イミダゾリニウムヒドロキサイド−1−カルボキシエチロキシ2ナトリウム塩等)、ベタイン系界面活性剤(アル
キルベタイン、アミドベタイン、スルホベタイン等)、アシルメチルタウリン等の両性界面活性剤類;ソルビタン脂肪酸エステル類(ソルビタンモノステアレート、セスキオレイン酸ソルビタン等)、グリセリン脂肪酸類(モノステアリン酸グリセリン等)、プロピレングリコール脂肪酸エステル類(モノステアリン酸プロピレングリコール等)、硬化ヒマシ油誘導体、グリセリンアルキルエーテル、POEソルビタン脂肪酸エステル類(POEソルビタンモノオレエート、モノステアリン酸ポリオキエチレンソルビタン等)、POEソルビット脂肪酸エステル類(POE−ソルビットモノラウレート等)、POEグリセリン脂肪酸エステル類(POE−グリセリンモノイソステアレート等)、POE脂肪酸エステル類(ポリエチレングリコールモノオレート、POEジステアレート等)、POEアルキルエーテル類(POE2−オクチルドデシルエーテル等)、POEアルキルフェニルエーテル類(POEノニルフェニルエーテル等)、プルロニック型類、POE・POPアルキルエーテル類(POE・POP2−デシルテトラデシルエーテル等)、テトロニック類、POEヒマシ油・硬化ヒマシ油誘導体(POEヒマシ油、POE硬化ヒマシ油等)、ショ糖脂肪酸エステル、アルキルグルコシド等の非イオン界面活性剤類;ポリエチレングリコール、グリセリン、1,3−ブチレングリコール、エリスリトール、ソルビトール、キシリトール、マルチトール、プロピレングリコール、ジプロピレングリコール、ジグリセリン、イソプレングリコール、1,2−ペンタンジオール、2,4−ヘキサンジオール、1,2−ヘキサンジオール、1,2−オクタンジオール等の多価アルコール類;ピロリドンカルボン酸ナトリウム、乳酸、乳酸ナトリウム等の保湿成分類;表面を処理されていても良い、マイカ、タルク、カオリン、合成雲母、炭酸カルシウム、炭酸マグネシウム、無水ケイ酸(シリカ)、酸化アルミニウム、硫酸バリウム等の粉体類;表面を処理されていても良い、ベンガラ、黄酸化鉄、黒酸化鉄、酸化コバルト、群青、紺青、酸化チタン、酸化亜鉛の無機顔料類;表面を処理されていても良い、雲母チタン、魚燐箔、オキシ塩化ビスマス等のパール剤類;レーキ化されていても良い赤色202号、赤色228号、赤色226号、黄色4号、青色404号、黄色5号、赤色505号、赤色230号、赤色223号、橙色201号、赤色213号、黄色204号、黄色203号、青色1号、緑色201号、紫色201号、赤色204号等の有機色素類;ポリエチレン末、ポリメタクリル酸メチル、ナイロン粉末、オルガノポリシロキサンエラストマー等の有機粉体類;パラアミノ安息香酸系紫外線吸収剤;アントラニル酸系紫外線吸収剤;サリチル酸系紫外線吸収剤;桂皮酸系紫外線吸収剤;ベンゾフェノン系紫外線吸収剤;糖系紫外線吸収剤;2−(2’−ヒドロキシ−5’−t−オクチルフェニル)ベンゾトリアゾール、4−メトキシ−4’−t−ブチルジベンゾイルメタン等の紫外線吸収剤類;エタノール、イソプロパノール等の低級アルコール類;ビタミンA又はその誘導体、ビタミンB6塩酸塩、ビタミンB6トリパルミテート、ビタミンB6ジオクタノエート、ビタミンB2又はその誘導体、ビタミンB12、ビタミンB15又はその誘導体等のビタミンB類;α−トコフェロール、β−トコフェロール、γ−トコフェロール、ビタミンEアセテート等のビタミンE類、ビタミンD類、ビタミンH、パントテン酸、パンテチン、ピロロキノリンキノン等のビタミン類等;フェノキシエタノール等の抗菌剤などが好ましく例示できる。これらの成分の内、特に好ましい形態は、液状化粧料がホホバ油、米胚芽油及び月見草油を含有する形態である。これはこの三種の油性成分の組合せが、前記三種の抱水性の液状油性成分と相溶性が高く、かかる成分を含有することにより、三層のエモリエント膜構造が上下強固に連結されるためである。この様な形態になるためには、ホホバ油、米胚芽油及び月見草油は等量乃至はこの三種の内で最も少ない成分の倍量をそれぞれ0.05〜5質量%含有することが好ましい。含有においてはマイクロエマルションの形態で含有することが好ましい。
The liquid cosmetic of the present invention can contain optional components that are usually used in cosmetics as long as the effects of the present invention are not impaired. Such optional ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, rice germ oil, evening primrose oil Oils such as liquid lanolin, hydrogenated coconut oil, hydrogenated oil, molasses, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, ibota wax, lanolin, reduced lanolin, hard lanolin, jojoba wax, waxes; liquid paraffin, squalane, pristane, Hydrocarbons such as ozokerite, paraffin, ceresin, petrolatum, microcrystalline wax; higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl Al Higher alcohols such as alcohol, isostearyl alcohol, behenyl alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, Cetyl lactate, diisostearyl malate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, tri-2-ethylhexanoic acid Synthetic ester oils such as trimethylolpropane, trimethylolpropane triisostearate, pentane erythritol tetra-2-ethylhexanoate; dimethylpolysiloxane Chain polysiloxanes such as methylphenyl polysiloxane and diphenyl polysiloxane; Cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexanesiloxane; amino-modified polysiloxane, polyether-modified polysiloxane, and alkyl-modified Oil agents such as silicone oils such as polysiloxanes, modified polysiloxanes such as polysiloxanes and fluorine-modified polysiloxanes; anionic surfactants such as fatty acid soaps (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkylethanol triethanolamine ether, etc. Cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride and laurylamine oxide; imidazoline-based amphoteric surfactants (2- Amphoteric surfactants such as cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt), betaine surfactants (alkylbetaine, amidebetaine, sulfobetaine, etc.), acylmethyltaurine; sorbitan Fatty acid esters (such as sorbitan monostearate, sorbitan sesquioleate), glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), PO Glycerin fatty acid esters (such as POE-glycerin monoisostearate), POE fatty acid esters (such as polyethylene glycol monooleate and POE distearate), POE alkyl ethers (such as POE2-octyldodecyl ether), POE alkylphenyl ethers (POE) Nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.) ), Nonionic surfactants such as sucrose fatty acid esters and alkyl glucosides; polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, mal Polyhydric alcohols such as tall, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1,2-hexanediol, 1,2-octanediol; pyrrolidone Moisturizing ingredients such as sodium carboxylate, lactic acid, sodium lactate; surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, barium sulfate Powders such as , etc . ; surface may be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments; surface may be treated Pearl agents such as titanium mica, fish phosphorus foil, bismuth oxychloride; may be raked Red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505, red 230, red 223, orange 201, red 213, yellow 204, yellow Organic dyes such as No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204; Organic powders such as polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer; Paraaminobenzoic acid series UV absorbers; anthranilic acid UV absorbers; salicylic acid UV absorbers ; cinnamic acid UV absorbers ; benzophenone UV absorbers; sugar UV absorbers; 2- (2′-hydroxy-5′-t-octyl) UV absorbers such as phenyl) benzotriazole and 4-methoxy-4′-t-butyldibenzoylmethane; ethanol, isopropanol Vitamin B such as vitamin A or derivatives thereof, vitamin B6 hydrochloride, vitamin B6 tripalmitate, vitamin B6 dioctanoate, vitamin B2 or derivatives thereof, vitamin B12, vitamin B15 or derivatives thereof; α- Preferred examples include vitamin E such as tocopherol, β-tocopherol, γ-tocopherol, vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone, and the like; and antibacterial agents such as phenoxyethanol. . Among these components, a particularly preferred form is a form in which the liquid cosmetic contains jojoba oil, rice germ oil and evening primrose oil. This combination of the oil component of the three types is, the three kinds of water-holding property of the liquid oil component compatible high, by the inclusion of such components, it is for emollient film structure of the three layers are vertically rigidly coupled . In order to obtain such a form, it is preferable that jojoba oil, rice germ oil and evening primrose oil contain 0.05 to 5% by mass of the same amount or the doubled amount of the smallest of these three components. In containing, it is preferable to contain in the form of a microemulsion.
以下に示す処方に従って、本発明の液状化粧料を製造した。即ち、イ、ロの成分を80℃に加温し、相溶させ、ロに徐々にイを加え乳化し、攪拌冷却し中間仕掛品のエマルションを作成した。これの1質量部を80℃に加熱し、攪拌可溶化したハの99質量部に加え、マイクロフルイダイザーで2回パスさせて、攪拌冷却して粘度1250mPsの液状化粧料1を得た。このものの乳化粒子の大きさは平均粒径が0.8μmであった。
The liquid cosmetic of the present invention was produced according to the formulation shown below. That is, components (a) and (b) were heated to 80 ° C. and dissolved, and (i) was gradually added to emulsify and stirred and cooled to prepare an intermediate work-in-process emulsion. 1 part by mass of this was heated to 80 ° C. and added to 99 parts by mass of the solubilized mixture C, passed twice with a microfluidizer, stirred and cooled to obtain a liquid cosmetic 1 having a viscosity of 1250 mPs. The average particle diameter of the emulsified particles was 0.8 μm.
本発明の液状化粧料1の効果を、ピロリドンカルボン酸オレイン酸グリセリルとダイマージリノール酸ダイマージリノレイルをスクワランに置換した比較例1(粘度1100mPs;平均乳化粒子径0.7μm)と、液状化粧料1の製造過程に於いてマイクロフルイダイザーを用いずに通常の反転乳化法で乳化して製造した比較例2(粘度1950mPs;平均乳化粒子径13μm)とを用い、ラウリル硫酸ナトリウム5%水溶液で損傷した皮膚のTEWLの変化を測定して調べた。損傷はラウリル硫酸ナトリウムを3時間貼付し行った。貼付後、部位を温水を含浸した脱脂綿で拭い、ラウリル硫酸ナトリウムを除去し、10分静置した後にTEWLをTewameter(Courage-Khazaakaelectronic GmbH,Cologne,Germany製)で測定した。液状化粧料で順次処理し、再びTEWLを計測した。計測後クレンジング料、洗顔料で液状化粧料を除去し、TEWLの値が元に戻っているのを確認し、同様に他の比較化粧料の評価を行った。結果を表1に示す。これより、本発明の液状化粧料は、優れた保湿効果を有し、以てTEWL(経皮的水分散逸)が低いことが判る。
The liquid-like effect of the cosmetic of the present invention, comparative example was replaced with pyrrolidone carboxylic acid glyceryl oleate and dimer dilinoleate die merge linoleyl in squalane 1; and (viscosity 1100mPs average emulsion particle size 0.7 [mu] m), a liquid In Comparative Example 2 (viscosity 1950 mPs; average emulsified particle diameter 13 μm) produced by emulsification by a normal reversal emulsification method without using a microfluidizer in the production process of the cosmetic 1, a 5% aqueous solution of sodium lauryl sulfate was used. The change in TEWL of the skin damaged by the measurement was measured and examined. The damage was made by applying sodium lauryl sulfate for 3 hours. After pasting , the part was wiped with absorbent cotton impregnated with warm water, sodium lauryl sulfate was removed, and after standing for 10 minutes, TEWL was measured with Tewameter (Courage-Khazaakaelectronic GmbH, Cologne, Germany). After sequentially treating with liquid cosmetics, TEWL was measured again. After the measurement, the liquid cosmetic was removed with a cleansing material and a face wash, and it was confirmed that the TEWL value had returned to its original value, and other comparative cosmetics were similarly evaluated. The results are shown in Table 1. From this, it can be seen that the liquid cosmetic of the present invention has an excellent moisturizing effect and thus has a low TEWL (transdermal water dispersion loss).
上記の液状化粧料1、比較例1、比較例2を用いて、肌状態が悪くて、且つ、ストレスを感じている人をパネラーにして2週間の試用テストを行った。社内の公募で集まった、肌状態が悪くて、且つ、ストレスを感じている人は12人で、この12人を3群に分けた。1群は液状化粧料1を、1群は比較例1を、1群は比較例2を2週間、連日朝晩2回投与してもらった。2週間後にアンケートで肌状態に改善があったか無いかと、ストレスによる心理的圧迫感の変化があったか無いかを答えてもらった。結果を表2に示す。本発明の液状化粧料は、肌状態を改善するとともに、ストレスによる心理的圧迫感を軽減していることが判る。
Using the liquid cosmetic 1, Comparative Example 1 and Comparative Example 2 described above, a trial test for 2 weeks was conducted with a person having a poor skin condition and feeling stress as a panelist. There were 12 people who were attracted by internal recruitment who had poor skin condition and felt stress, and these 12 people were divided into 3 groups. Group 1 was given liquid cosmetic 1, Group 1 was given Comparative Example 1, Group 1 was given Comparative Example 2 for 2 weeks , twice daily in the morning and evening. Two weeks later, a questionnaire asked whether there was any improvement in skin condition and whether there was any change in psychological pressure due to stress. The results are shown in Table 2. It can be seen that the liquid cosmetic of the present invention improves the skin condition and reduces the psychological pressure caused by stress.
実施例1と同様に、下記処方に従って、本発明の液状化粧料2(粘度1450mPs;平均粒径0.8μm)を作成した。このものを実施例1のTEWLへの変化と同様の手技で評価した。結果はコントロールが52だったものが、処置後32に減った。これより、
同様の効果が存するものと思われるが、ホホバ油、米胚芽油及び月見草油を含有する形態の方が好ましいことが推察される。
As in Example 1, according to the following formulation, a liquid-like cosmetic 2 of the present invention; was created (viscosity 1450mPs average particle size 0.8 [mu] m). This was evaluated by the same procedure as the change to TEWL in Example 1. The result was that the control was 52 but decreased to 32 after treatment. Than this,
Although it seems that the same effect exists, it is guessed that the form containing jojoba oil, rice germ oil, and evening primrose oil is more preferable.
実施例1と同様に、下記処方に従って、本発明の液状化粧料3(粘度1200mPs;平均粒径0.7μm)を作成した。このものを実施例1のTEWLへの変化と同様の手技で評価した。結果はコントロールが53だったものが、処置後29に減った。これより、この化粧料も実施例1の液状化粧料1と同様の効果を有することが推察される。 As in Example 1, according to the following formulation, a liquid-like cosmetic 3 of the present invention; was created (viscosity 1200mPs average particle size 0.7 [mu] m). This was evaluated by the same procedure as the change to TEWL in Example 1. The result was that the control was 53 but decreased to 29 after treatment. From this, it is guessed that this cosmetic also has the same effect as the liquid cosmetic 1 of Example 1.
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