JP2006136250A - System for controlling thermostatic device for medical use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To readily constitute a system for surely preventing an error of mistaking cells and cross-over contamination even in the case of installing a plurality of thermostatic devices for medical use having different specifications caused by a variety of makers and types in a testing room and integratively controlling them. <P>SOLUTION: In the control system in which a plurality of incubators 24 are arranged in a culture operation room 12 and cells of different donors are treated in each incubator 24, a supporting frame 40 stood on the floor 60 of the culture operation room 12 is equipped with lock units 38 and 110 for controlling the opening and closing of doors 24A for each incubator 24. Consequently, the lock units 38 and 110 are installed separately from the incubators 24. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a medical thermostat management system, and more particularly to a medical thermostat management system provided in a facility for culturing and processing using cells and tissues of humans and animals as raw materials.

Facilities such as bio-related companies that cultivate and process human and animal cells and tissues as raw materials (for example, facilities that manufacture contracted specific cells, cultured skin, cultured cartilage, etc.), and large-scale In a facility such as a hospital equipped with an incubator (for example, a CO ₂ incubator) for culturing patient cells for the purpose of autotransplantation treatment, the cells are cultured for several weeks. Hereinafter, the term “cell” includes tissues.

  In this culturing operation, a culture medium exchange operation (medium exchange) and a subculture operation in which the proliferated cells are divided into a plurality of containers are performed. In the culturing operation, contamination with bacteria, cross-contamination, and other people's cells are mixed. Preventing mistakes and the like is the most important item for ensuring safety, and careful attention is required. For this purpose, it is necessary to cultivate only one donor in one culture work room (a cell culture room).

  Therefore, in order to be able to culture cells of a plurality of donors at the same time, a culture work room is required as many as the number of donors. As a result, it is necessary to construct a cell preparation room in which a large number of culture work rooms are gathered, which increases the size of the equipment, complicates sterility management, and increases the construction cost and maintenance cost. Moreover, when using the existing equipment space in a hospital, there is a high possibility that a culture room with a sufficient number of donors cannot be secured.

  From such a background, it is necessary to provide a plurality of incubators in the same culture work room and to manage the culture of one donor cell with one incubator. Therefore, it is absolutely necessary to have a management system that prevents mistaken donor cell mistakes.

  To prevent mistakes in donor cell mistakes, (1) create a standard operating procedure and follow it, (2) double-check the verification on the document with the actual target cell, (3) In general, management is performed by attaching an identification mark or a barcode to a cell culture vessel, an incubator, or the like, but it is not sufficient.

As a countermeasure, for example, Patent Document 1 discloses a sample (cell) mix prevention and management system in which information necessary from registration to disposal of each sample is managed by a computer. Further, in Patent Document 2, each of the plurality of incubators (each cell) has a detector corresponding to an individual key, and the response of this detector can open and close the open / close door of each cell. Human cells designed to prevent erroneous operations such as removing cells from other incubators by interlocking the functions of the detectors of other cells with the response of one cell detector. A tissue culture system is disclosed.
JP 2004-215611 A Japanese Patent Laid-Open No. 2004-16094

  However, even if information necessary from registration to disposal of each specimen is managed by a computer as in Patent Document 1, it is a human task, so it is a cause of misjudgment, inadvertent mistakes when busy, etc. There is a drawback in that an operator may take out cells from two incubators during a certain working time and handle another donor cell in parallel. For example, while waiting for one donor cell to be centrifuged, the cells removed from the incubator of another donor are observed with a microscope. In this case, when an operator touches the cells of a different donor, there is a risk of cross-contamination, and when returning to the incubator, there is a case where the operator makes a mistake.

  Also, as in Patent Document 2, when opening and closing the doors of individual incubators is managed with a key corresponding to the detector to prevent cell confusion, the number of keys required for the number of incubators is complicated. Not only that, the key used to open and close the incubator door is contaminated and must be sterilized and reused each time. Therefore, the management method using the key is not appropriate because of the complexity of management and the possibility of cross contamination due to a sterilization operation error.

  In this way, when there are multiple incubators in the same culture work room and one donor cell is used for culture management, there is no way to reliably prevent mistakes and cross contamination. It is.

  A system is also conceivable in which a plurality of incubators themselves are provided with a lock mechanism, and the lock mechanism is controlled by, for example, a computer so that only the target incubator door can be opened and closed. The locking mechanism differs depending on the model, and the shape and size of the incubator are often different. This complicates the system so that different manufacturers and types of incubators cannot be used together. Therefore, it is not limited to the manufacturer or model, but for example, it is not possible to integrate and manage multiple incubators with different specifications that meet the user's required specifications for each cell to be cultured. Is the actual situation.

  The system that reliably prevents mistakes and cross contamination is not limited to incubators, and is not limited to incubators, and is not limited to different specifications depending on manufacturers and models. This technology is necessary for all medical thermostats that handle samples.

  The present invention has been made in view of such circumstances, and even when a plurality of medical thermostats having different specifications depending on the manufacturer and model are provided in the test room for integrated management, mistakes such as sample misplacement of cells, It is an object of the present invention to provide a management system for a medical thermostat capable of easily constructing a system for reliably preventing cross contamination.

  In order to achieve the above object, a first aspect of the present invention provides a medical thermostat management system in which a plurality of medical thermostats are provided in a test chamber and different samples are handled in each medical thermostat. The lock unit is provided separately from the medical thermostat by providing a lock unit for managing the opening and closing of the door for each thermostat on a support frame standing on the floor of the test chamber. And

  Claim 1 provides a lock unit that is separate from the medical thermostat by providing a lock unit for managing the opening and closing of the door for each medical thermostat on a support frame standing on the floor of the test room. Therefore, even when multiple thermostats with different specifications depending on the manufacturer and model are installed in the test room for integrated management, it is easy to create a system that reliably prevents sample mistakes and cross contamination. Can be built.

  A second aspect of the present invention is characterized in that, in the first aspect, the test room is a culture work room for performing work related to cell culture as the sample, and the medical thermostat is an incubator.

  The second aspect is an example in which the present invention can be utilized to the maximum extent, and is a case where a plurality of incubators are provided in a culture work room, and the cells of one donor are cultured and managed with one incubator.

  A third aspect of the present invention is the first or second aspect, wherein the lock unit includes a lock position where the door of the medical thermostat cannot be opened and a lock arm movable to the open position where the door can be opened, and the lock arm is locked. It is characterized by comprising: lock means for locking in position; switch means for releasing the lock of the lock means; and display means for displaying permission to open the door.

  The lock unit according to claim 3 is a manual type configuration in which a person manually moves the lock arm. When the lock means is unlocked by the switch means, the operator can move the lock arm to the open position. Thereby, the operator can open the door of the medical thermostat. Further, when the door is closed and the lock arm is returned to the lock position, the lock means is locked and the lock arm cannot move at the lock position. Thereby, the door of the medical thermostat is locked and cannot be opened.

  According to a fourth aspect of the present invention, in the first or second aspect, the lock unit includes: a lock position where the door of the medical thermostat cannot be opened; a lock arm movable to the open position where the door can be opened; A driving means for moving between a position and the opening position, a switching means for turning on and off the driving means, and a display means for displaying permission to open the door are provided.

  The lock unit according to a fourth aspect of the present invention is an automatic type structure that automatically moves the lock arm. When the switch means is turned on, the drive means automatically moves the lock arm to the open position. Thereby, the operator can open the door of the medical thermostat. When the door is closed and the switch means is turned OFF, the drive means returns the lock arm to the lock position. Thereby, the door of the medical thermostat is locked and cannot be opened.

  A fifth aspect of the present invention is characterized in that a lock arm position confirmation sensor for confirming whether the lock arm is in the locked position or the open position is provided in the third or fourth aspect.

  A lock arm position confirmation sensor that confirms whether the lock arm is in the locked position or in the open position, and it can be confirmed whether the door of the medical thermostat has been securely locked, thus preventing forgetting of the lock. it can.

  A sixth aspect of the present invention is characterized in that, in any one of the third to fifth aspects, the lock unit includes a door open / close confirmation sensor for confirming whether the door of the medical thermostat is in an open state or a closed state. To do.

  A door open / close confirmation sensor is provided to check the open / closed state of the medical thermostatic door, and it can be confirmed whether the medical thermostatic door is closed securely. It is possible to prevent temperature conditions in the chamber from fluctuating.

  A seventh aspect of the present invention is characterized in that, in any one of the third to sixth aspects, the switch means and the display means are configured as one means by a push button lamp that is turned on when the switch is pressed and the lamp is lit. To do.

  Thereby, the lock unit can be made compact.

  An eighth aspect of the present invention is the method according to any one of the first to seventh aspects, wherein the support frame is provided with a plurality of the lock units, and the plurality of lock units are individually provided in the vertical direction, the width direction, and the depth of the medical thermostat. A slide mechanism that slides in at least one direction is provided.

  Since the lock unit can be individually slid in at least one of the vertical direction, width direction, and depth direction of the medical thermostat, the shape and size of the medical thermostat differs depending on the manufacturer and model But it becomes easier to handle.

  A ninth aspect of the present invention is characterized in that, in any one of the third to eighth aspects, the display means of the lock unit is displayed by a signal from a centralized control panel provided outside the culture work chamber.

  As a result, the worker who enters the culture work room and works can visually confirm which of the plurality of medical thermostats is the medical thermostat that performs the work. This prevents mistakes that might be mistaken for a thermostat.

  A tenth aspect of the present invention is the method according to the ninth aspect, wherein the central control panel is provided with an operator designation mechanism for designating one worker for each of a plurality of medical thermostats provided in the test chamber. It is characterized by.

  In this way, if one worker in charge of each of the plurality of medical thermostats is designated, not only can mistakes mistaken for other medical thermostats be prevented, but cross contamination will not occur.

  An eleventh aspect is characterized in that, in the tenth aspect, the operator specifying mechanism is a double management of password management and barcode management.

  In this way, if the operator is specified by double management of password management and barcode management, it is safer against mistakes and cross contamination.

  A twelfth aspect according to any one of the first to eleventh aspects is characterized in that the support frame also serves as a gantry on which the medical thermostat is placed.

  By providing the support frame with the function of a gantry on which the medical thermostat is placed, the entire apparatus can be made compact.

  Claim 13 is any one of claims 3 to 12, wherein the lock unit is provided with alarm means for sounding an alarm when the timer means operates in conjunction with the activation of the switch means and the time is up. It is characterized by being.

  Thereby, it is possible to prevent the operator from performing a medium replacement operation, a subculture operation, or the like while forgetting to close the medical thermostat door.

  As described above, according to the medical thermostat management system of the present invention, even when a plurality of medical thermostats with different specifications depending on the manufacturer and model are provided in the test room for integrated management, a sample such as a cell It is possible to easily construct a system for reliably preventing mistakes and cross contamination.

  A preferred embodiment of a medical thermostatic management system according to the present invention will be described in detail below with reference to the accompanying drawings. In the present embodiment, a culture work room for performing work related to cell culture as a test room and a culture incubator (incubator) as an example of a medical thermostat will be described, but the present invention is not limited thereto. It can be applied to medical thermostats that handle different samples in medicine and biotechnology.

  FIG. 1 is a sketch diagram showing an example of a cell preparation chamber 10 in which the medical thermostatic management system of the present invention is incorporated.

  As shown in FIG. 1, the cell preparation chamber 10 is divided into three chambers: a culture work room 12, a changing room 14, and a dressing room 16, and a worker who works in the culture work room 12 is a door for a changing room. 18 enters the changing room 14. In the changing room 14, an operator changes his / her private clothes to a clean suit or clean shoes, disinfects his hands in the hand washing area 15, and then enters the culture work room 12 through the culture work room entrance door 20. In the culture work chamber 12, a clean bench 22, a plurality of incubators 24, 24..., A centrifuge 26, an inverted phase contrast microscope 30 placed on a work table 28, and the like are provided. In addition, a centralized control panel 13 that integrates and manages a plurality of incubators 24 provided in the culture work chamber 12 is provided on the outer surface of the side wall that forms the culture work chamber 12.

  The clean bench 22 is a device that performs cell preparation work in an atmosphere of class 100 or lower, and an operator removes cells from a dish or flask or the like and adds an enzyme solution or a washing solution, or places the cells in a new container. Perform separate subculture work.

  The incubator 24 is a device for storing cells in a container such as a dish or flask and culturing the cells, and the temperature and carbon dioxide concentration are controlled, and the culture conditions are controlled to be constant. . In the present invention, a plurality of incubators 24 are provided in the culture work chamber 12, and different donor cells are cultured for each incubator 24.

  The centrifuge 26 is a device that puts cells with an enzyme solution in a container into a centrifuge tube, centrifuges the cells and liquid, or centrifuges with a washing solution. The operator separates the container into a new container in the clean bench 22 described above.

  The inverted phase-contrast microscope 30 is a device that observes the cells in culture taken out from the incubator 24 together with the container and confirms whether there is any abnormality (for example, contamination) during the culture.

  A typical operation performed by the operator in the culture work chamber 12 using the above-described apparatus and equipment is as follows. That is, the cells are placed in a container containing a culture medium and cultured in the incubator 24 (culture operation). This medium is changed around 3 days (medium exchange work). Since the cells in the container fill up in about one week, the cells are divided into new containers (passaging work). Cell culture is completed by performing the passage work about 4 times. During culture, the cells in the incubator 24 are observed with an inverted phase contrast microscope 30 periodically (about once a day).

  The worker who has finished the work in the culture work room 12 enters the undressing room 16 through the culture work room exit door 32, removes a clean suit, clean shoes, etc. and changes to plain clothes, and disinfects his hands in the hand washing area 34. Then, the cell preparation chamber 10 is removed from the dressing room door 36.

  By the way, as described above, in the case where a plurality of incubators 24 are provided in the same culture chamber 12, and one donor cell is cultured and managed by one incubator 24, when an operator works, It is necessary to reliably prevent cell mistakes and cross contamination.

  2 and 3, the same culture work chamber 12 has two rows stacked in two rows for a total of four incubators 24, and is a manual type lock that manages the opening and closing of the door 24 </ b> A for each incubator 24. FIG. 6 is an explanatory diagram illustrating a unit 38. The lock unit 38 is a device that manages the opening / closing of the door 24A for each incubator 24 while being supported by a support frame 40 standing on the floor surface 60 of the culture work chamber 12. It is provided as a body device. 2 and 3 has the hinge 17 of the door 24A on the left side of the incubator 24 (see FIGS. 2 and 3B), and the door 24A is opened from right to left.

  As a type of the lock unit 38, there are a manual type in which the lock arm 42 is driven by an operator's human power and an automatic type in which the lock arm 42 is automatically driven by a driving means. First, in FIG. 2 and FIG. A manual type example will be described. 2 is an overall configuration diagram, FIG. 3 is an enlarged view of the vicinity of the lock unit, and in FIGS. 2 and 3, (A) is a front view, (B) is a top view, and (C) is a right side view. , (D) is a left side view.

  As shown in FIGS. 2 and 3, the manual type lock unit 38 mainly includes a lock arm 42 that is movable to a lock position a where the door 24 </ b> A of the incubator 24 cannot be opened, and an open position b where the door 24 </ b> A can be opened. Lock means 44 for locking the lock arm 42 at the lock position a, switch means for unlocking the lock means 44, and lock arm position confirmation for checking whether the lock arm 42 is in the lock position a or the open position b A sensor 46, a display means for displaying permission to open the door 24A, a door opening / closing confirmation sensor 48 for confirming whether the door 24A is in an open state or a closed state, an alarm device 50 linked at least with an alarm timer (not shown), It consists of an alarm push button lamp 52 that stops the alarm of the alarm device 50 and resets the alarm timer. It is supported by the 40. Further, the switch means and the display means are constituted as one means by the push button lamp 54.

  As shown in FIG. 2, the support frame 40 has two inverted T-shaped support columns 56, 56 facing each other at an interval corresponding to the width of the incubator 24, and the lower ends of the two support columns 56, 56. The position and the upper position are connected by connecting rods 58 and 58, respectively. And these two support | pillars 56 and 56 are stood on the floor surface 60 stably by extending | stretching between the floor surface 60 and the ceiling surface 62 of the culture | cultivation working chamber 12 with something like a tension jig. Let

  The support frame 40 is provided with lock units 38 corresponding to the number of stages in which the incubator 24 is stacked. In FIG. 2, since the incubators 24 are provided in two rows in a two-tier stack, a total of two incubators 24 are provided for each row of the support frame 40, and two locks are provided in the upper and lower stages of each support frame 40, respectively. A unit 38 is provided. The support frame 40 may be of a type that also serves as a gantry on which the incubator 24 is placed, as will be described later with reference to FIG.

  Next, the structure of the lock unit 38 will be described. The base ends of the pair of swing arms 66 and 66 are swingably supported by hinges 64 and 64 fixed to the two columns 56 and 56, respectively. Both ends of the lock arm 42 are supported on the tip portions of the pair of swing arms 66, 66, respectively. Thus, the operator can manually open the door 24A of the incubator 24 by swinging the lock arm 42 from the lock position a to the open position b, and the door 24A is locked by returning to the lock position a. The As a material of the lock arm 42, an elastic member such as silicon rubber may be used so as to reduce the impact when it hits the door 24A of the incubator 24. In the present embodiment, the lock arm 42 is swung so that it can move between the lock position a and the open position b. It may be a case of linearly moving between the position b.

  2C and 3C supports a device box 68 of the lock unit 38, and the device box 68 has the locking means 44, the push button lamp 54, and the lock arm. A position confirmation sensor 46, a door opening / closing confirmation sensor 48, an alarm device 50, and an alarm push button lamp 52 are provided.

  As the lock means 44 for locking the lock arm 42 at the lock position a, for example, a solenoid valve can be suitably used. As shown in FIG. 4, a drive member (not shown) of the solenoid valve is provided with a hook member 44A that can swing in the CD direction and is urged in the C direction. On the other hand, an L-shaped engagement member 66 </ b> A that engages with the hook member 44 </ b> A is provided on the lower surface of the swing arm 66 on the base end side. Thus, when the operator swings the lock arm 42 downward (in the lock position a direction), the engaging member 66A hits the taper portion 44B of the hook member and swings the hook member 44A in the D direction. 44A and the engaging member 66A are engaged. Thereby, the movement of the lock arm 42 is locked. When releasing the lock, the push button lamp 54 is pressed to release the lock of the solenoid valve, so that the drive portion of the solenoid valve is driven to swing the hook member 44A in the D direction. Accordingly, the engagement between the hook member 44A and the engagement member 66A is released, and the lock arm 42 can be moved to the open position b.

  On the other hand, as shown in FIG. 3D, the left column 56 is provided with a swing support mechanism 70 that supports the swing of the lock arm 42. The swing support mechanism 70 includes a support rod 74 having a nested structure in which a thick tube and a thin tube are slidably fitted between an L-shaped member 72 supported by a support column 56 and a central portion of the swing arm 66. Both ends are connected by pins 76 and 76. Thus, when the lock arm 42 swings between the lock position a and the open position b, the pin-connected telescopic support rod 74 expands and contracts, so that the swing of the lock arm 42 can be supported.

  In this way, the lock unit 38 that manages the opening and closing of the door 24A of the incubator 24 is not provided in the incubator 24, but is a separate device from the incubator 24, so that incubators of different manufacturers and types can be used. 24 is no problem.

  FIG. 5 shows a modified example of the lock unit 38, in which a plurality of lock units 38 are individually moved in the vertical direction (ZZ direction), the width direction (YY direction), and the depth direction (X-) of the incubator 24. It can be slid in the X direction). 5A is a right side view, and FIG. 5B is a top view.

  In other words, the support column 56 is provided with a pair of rails 78, 78 parallel to the vertical direction (Z-Z direction), and an L-shaped mounting base 82 is slidably supported on the rails 78 via linear bearings 80. Is done. A pair of rails 84, 84 parallel to the width direction (YY direction) of the incubator 24 are provided on the upper surface of the mounting table 82, and a plate-like slide table 88 is provided on the rail 84 via a linear bearing 86. Supported slidably. Further, stoppers 84 </ b> A are provided at both ends of the rail 84. A pair of rails 90, 90 parallel to the depth direction (XX direction) of the incubator 24 are provided on the upper surface of the slide table 88, and the instrument box 68 is slidable on the rail 90 via a linear bearing 92. Supported. Further, stoppers 90 </ b> A are provided at both ends of the rail 90.

  Thereby, the lock unit 38 can slide in the up-down direction (ZZ direction), the width direction (YY direction), and the depth direction (XX direction) of the incubator 24. As a drive source for sliding the mounting table 82, the slide table 88, and the device box 68, a ball screw mechanism, a cylinder mechanism, or the like can be suitably used, although not particularly illustrated. In addition, the code | symbol 67 of FIG. 5 (B) is a safety pin for fixing the lock unit 38 reliably after moving the lock unit 38 to the up-down direction (Z-Z direction) of the incubator 24. 56 and the mounting base 82 are connected.

  As described above, the plurality of lock units 38 provided on the support column 56 are individually provided in the vertical direction (Z-Z direction), the width direction (Y-Y direction), and the depth direction (XX direction) of the incubator 24. Since it can slide, even when the incubators 24 having different heights, widths or depths of the doors 24A are stacked, the lock arm 42 can be aligned at an appropriate position according to the incubator 24. It becomes even more convenient.

  On the other hand, the centralized control panel 13 provided on the outside of the side wall of the culture work room 12 is one incubator in which a worker works in the culture work room 12 among the plurality of incubators 24 that are integrated and managed. 24, a selection switch for transmitting a signal for turning on only the push button lamp 54 of the lock unit 38 corresponding to 24 is provided. The signal transmitted from the central control panel 13 is transmitted to the device box 68 of the lock unit 38 via the relay terminal box 94 (see FIG. 2) attached to the upper connecting rod 58 of the support frame 40. . The transmission method may be wired or wireless.

  As shown in FIG. 6, as the selection switch of the centralized control panel 13, the touch panel system shown in FIG. 6A or the key selection system shown in FIG. 6B can be preferably used. In the touch panel system shown in FIG. 6A, a person touches a selection touch switch display 96B (for example, a number) on a password input screen 96A formed on the touch panel 96 and inputs the password, thereby incubating the incubator 24 for work purposes. This is a method of selecting the lock unit 38 corresponding to (No1 to No4). 6B, the select switch key 98 is inserted into the key hole 100 to release the lock of the select lever 102, and the select lever 102 corresponds to the incubator for the work purpose (No1 to No4). This is a method for selecting the lock unit 38 to be used. In this embodiment, the touch panel method is used.

  Further, the central control panel 13 is provided with a power push button lamp 104 which is a power source for the main power source and the operation power source, and informs that the lock unit 38 corresponding to the incubator 24 for work is being unlocked. A pilot lamp 106 is provided. The drive power for the clean bench 22, the incubator 24, the centrifuge 26, and the inverted phase-contrast microscope 30 placed on the workbench is taken from the central control panel 13, but a separate power panel is provided. Also good.

  In FIG. 7, only one support 56 constituting the support frame 40 of the lock unit 38 is erected on the hinge 17 side of the door 24 </ b> A of the incubator 24, and a plurality of lock units 38 are provided on this one support 56. It is a thing. FIG. 7A is a front view and FIG. 7B is a top view.

  In this case, the lock arm 42 is supported by the support 56 so that it can swing freely via the swing arm 66 and the hinge 64.

  As described above, when the support frame 40 is constituted by one support column 56, the support column 56 must be erected on the hinge 17 side of the door 24 </ b> A of the incubator 24. This is because if the door 24 </ b> A of the incubator 24 is not completely closed, the lock arm 42 cannot be swung to the lock position “a” if it is erected on the hinge 17 side.

  FIG. 8 is an example of an automatic type lock unit 110, where (A) is a front view, (B) is a top view, and (C) is a right side view. The same members as those of the manual type lock unit 38 will be described with the same reference numerals.

  As shown in FIG. 8, the automatic type lock unit 110 mainly includes a lock arm 42 that is movable to a lock position “a” where the door 24 </ b> A of the incubator 24 cannot be opened, and an open position “b” that can be opened, and the lock arm 42. Is moved between the lock position a and the open position b, a switch means for turning the drive means ON and OFF, a display means for displaying permission to open the door 24A, and the lock arm 42 at the lock position a. A lock arm position confirmation sensor 46 for confirming whether the door 24A is in the open position b, a door opening / closing confirmation sensor 48 for confirming whether the door 24A is in the open state or the closed state, and an alarm device linked at least with an alarm timer (not shown). 50 and an alarm push button lamp 52 for stopping the alarm of the alarm device 50 and resetting the alarm timer are provided in the equipment box 114. The equipment box 114 is supported by the support frame 40.

  The switch means and the display means are configured as one means by the push button lamp 54. As the driving means 112 for moving the lock arm 42 to the lock position a and the open position b, for example, a combination of a rotary solenoid 112A and a biasing means 112B (for example, a spring spring) that biases the rotational force is preferably used. be able to. That is, the rotary shaft 112 is supported by the rotary solenoid 112A, the lock arm 42 is attached to the tip thereof, and the rotary shaft 116 is applied with a rotational force from the open position b to the lock position a by the biasing means 112B. The device box 114 is formed with a notch 113 at a portion where the lock arm 42 rotates. When the lock arm 42 is in the open position b, the lock arm 42 is accommodated in the device box 114.

  When the push button lamp 54, which is a switch of the driving means 112, is pressed to turn on the switch, the rotary solenoid 112A is driven to rotate the lock arm 42 from the lock position a to the open position b. When the push button lamp 54 is pressed again to turn off the switch, the urging means 112B returns the lock arm 42 from the open position b to the lock position a. Reference numeral 118 denotes a bearing, 120 denotes a cylindrical member (bush) that supports the rotating shaft 116, and 122 denotes a transmission / reception cable between the central control panel 13 and the lock unit 38. In the automatic type lock unit 110, the lock unit 110 is individually slid in the vertical direction (ZZ direction), the width direction (YY direction), and the depth direction (XX direction) of the incubator 24. Although the mechanism for making it not shown is shown, it is preferable to provide a slide mechanism similar to that shown in FIG.

  FIG. 9 shows an automatic type lock unit 110 applied to a total of four incubators 24 in two rows and two rows. The support frame 40 is a type that also serves as a frame on which the incubator 24 is placed, and is composed of left and right side plates 40A and 40B, a bottom plate 40C, a top plate 40D, and a shelf plate 40E. A caster 124 and a lock member 126 that locks the movement of the support frame 40 are provided. The top plate 40D and the shelf plate 40E are provided with lock units 38 corresponding to the four incubators 24, respectively.

  FIG.10 and FIG.11 is the flowchart which showed the step flow of the operating method of the management system of a medical thermostat. In the culture work chamber 12, four incubators 24 of No 1 to No 4 are provided, and an example in which cells of different donors are cultured in each incubator 24 will be described.

  The main power source and the operating power source are turned on by pushing the power pushbutton lamp 104 of the centralized control panel 13 (step 10). As a result, the push button lamp 104 for power is turned on, and the centralized management panel 13 can be operated. Next, a separate touch switch 96B on the password input screen 96A formed on the touch panel 96 of the centralized control panel 13 by a manager who is different from the worker working in the culture work room 12 and manages the management system. The numbers 1 to 4 are touched to input the administrator password (steps 12 and 14). As a result, the management system of the present invention is started and the operator's touch panel input becomes possible. If the administrator enters the password by mistake, the process returns to step 14 again.

  Next, the worker touches the selection touch switch 96B on the password input screen 96A and inputs the worker's password (step 16). As a result, only one of the numbers on the selection touch switch 96B blinks (step 18). If the operator enters the password by mistake, the process returns to step 16 again. The four incubators 24 (denoted as incu in FIG. 10) No. 1 to No. 4 provided in the culture work chamber 12 are designated by each incubator 24, and the password and culture of the operator are designated. No of the container 24 is associated. In FIG. 10, the worker has a password for the incubator 24 of No1. In this way, by providing an operator specifying mechanism in the centralized control panel 13 for handling one incubator 24 by one operator in association with the password of the operator and the incubator 24 No. It is possible to prevent the cells of the vessel 24 from being mixed up and causing cross contamination. In this case, in order to avoid the risk that a password entered by an operator by mistake will match the password of another worker, the barcode unique to the worker, for example, is entered separately from the password entry. It is more preferable to perform a double check by inserting a card having identification information such as the above into a reader (not shown) of the central control board 13.

  Next, when the operator touches the blinking number 1, the blinking is turned on, and when the wrong number is touched, the process returns to step 18 again. The operator confirms that the number 1 has turned on from blinking, and touches the touch switch of “confirm” 97 on the touch panel screen 96 (step 20). As a result, the No. 1 pilot lamp among the No. 1 to No. 4 pilot lamps (PL) 106 of the central control panel 13 is turned on, and the push button of the lock unit 38 corresponding to the No. 1 incubator 24 in the culture work chamber 12. The lamp 54 is turned on. Therefore, when entering the culture work chamber 12, the operator can recognize without any mistake which of the incubators 24 the lock unit 38 should be handled. If the operator touches an incorrect part other than “Confirm” 97, the process returns to Step 20.

  Next, the worker enters the culture work chamber 12 and presses the push button lamp 54 of the lock unit 38 that is lit (step 22). As a result, a switch (for example, a solenoid valve) that locks the movement of the lock arm 42 automatically releases the lock. By automatically releasing the lock, the No. 1 pilot lamp 106 of the central control panel 13 changes from lighting to blinking, and the push button lamp 54 of the lock unit 38 changes from lighting to blinking. By changing from this lighting to blinking, the administrator can know that the lock of the No. 1 incubator 24 is being released by the central control panel 13, and the operator can press the push button lamp 54 of the lock unit 38 to No. 1. It can be known that the lock of the incubator 24 is being released. If the operator accidentally presses the push button lamp 54 (not lit) of the lock unit 38 other than the No. 1 incubator 24, the lock is not released, so the process returns to step 20 and is lit again. The push button lamp 54 of the lock unit 38 is pushed.

  Next, in the case of the manual type lock unit 38, the operator manually moves the lock arm 42 from the lock position a to the open position b (step 24). In the case of the automatic type lock unit 110, when the push button lamp 54 is pressed and the lock is automatically released, the driving means 112 of the lock arm 42 is driven in conjunction therewith to automatically lock the lock arm 42 to the lock position a. To the open position b. As a result, the door 24A of the No. 1 incubator 24 can be opened, so that the operator opens the door 24A, takes out the culture vessel for the cells being cultured, and works in the culture work chamber 12. When the lock arm 42 moves from the lock position a to the open position b, the lock arm position confirmation sensor 46 is turned off, and the monitoring timer starts to operate in conjunction therewith. The operator opens the door 24A of the No1 incubator 24 within the time-out of the monitoring timer (for example, 1 minute), takes out the culture vessel for the cultured cells, closes the door 24A again, and opens the lock arm 42 to the open position. Return from b to the lock position a (step 26 to step 30). As a result, the lock arm position confirmation sensor 46 is turned on, the monitoring timer is reset, and a switch (for example, a solenoid valve) that locks the movement of the lock arm 42 is locked. By this locking operation, the No. 1 pilot lamp 106 flashing on the central control panel 13 changes from flashing to lighting, and the push button lamp 54 flashing on the lock unit 38 changes from flashing to lighting. By changing from flashing to lighting, the administrator can know that the door 24A of the No. 1 incubator 24 has been closed and locked again by the centralized control panel 13, and the operator can push the push button of the lock unit 38. It can be known from the lamp 54 that the No. 1 incubator 24 has been locked again. If the lock arm 42 is not returned to the lock position a even when the door 24A of the incubator 24 is closed, the lock arm position confirmation sensor 46 remains in the OFF state, and the alarm device 50 issues an alarm. Thereby, it is possible to prevent the worker from leaving the culture work chamber 12 without the door 24A of the incubator 24 being locked.

  The door opening / closing confirmation sensor 48 is activated by opening / closing the door 24A. The door opening / closing confirmation sensor 48 is turned off when the door 24A is opened, and is turned on when the door 24A is closed. In the case of the automatic type, by pressing the push button lamp 54 again to turn it off, the driving means 112 of the lock arm 42 may automatically drive the lock arm from the open position b to the lock position a. Alternatively, when the door opening / closing confirmation sensor 48 is turned on, the driving means 112 may be driven.

  If the operator removes the culture vessel from the No1 incubator 24 and forgets to close the door 24A and the monitoring timer expires (for example, 1 minute), a push button lamp for alarming the door abnormality 52 flashes and an alarm 50 sounds to inform the operator that the door 24A is open. Since the alarm device 50 is stopped by pressing the push button lamp 52 for alarming the door abnormality, the monitoring timer is reset when the push button lamp 52 is pressed again after canceling the cause of the alarm device 50 sounding.

  When the worker finishes the work in the culture work chamber 12, the worker returns to the step position indicated by A in FIG. 10 again, and repeats the operations of Step 22 to Step 30 to place the culture vessel in the No1 incubator 24. Return to the cell preparation room 10 through the dressing room 16.

  When the administrator confirms that the worker has come out of the cell preparation chamber 10, the numbers 1 to 4 corresponding to the selection touch switch 96B on the password input screen 96A formed on the touch panel 96 of the central control panel 13 are displayed. Touch to enter the administrator's password (steps 32 and 34). Thereby, an operator's touch panel input becomes possible. If the administrator enters the password by mistake, the process returns to step 34 again.

  Next, the worker touches the selection touch switch 96B on the password input screen 96A and inputs the worker's password (step 36). As a result, only one of the numbers on the selection touch switch 96B blinks (step 38). If the operator enters the password by mistake, the process returns to step 36 again. Next, when the operator touches the blinking number 1, the blinking lights up, and when the wrong number is touched, the process returns to step 38 again. Next, the operator confirms that the number 1 has been turned on from blinking, and touches the touch switch of “confirm” 97 on the touch panel screen 96 (step 40). As a result, the No. 1 pilot lamp (PL) 106 of the central control panel 13 is turned off, and the push button lamp 54 of the lock unit 38 corresponding to the No. 1 incubator 24 in the culture work chamber 12 is turned off. Thereby, a series of steps of the medical thermostatic management system shown in the example of the No. 1 incubator 24 is completed. If the operator performs the work again in the culture work chamber 12, the process returns to the step position indicated by B in FIG.

  In this case, returning to the step position indicated by B in FIG. 10 is not efficient because the management system of the present invention is started. Therefore, if the worker performs the work again in the culture work room 12, the worker may return to step 16 in which his / her password is input.

  Further, in the above step flow, by providing an operator specifying mechanism that associates the operator's password with the No of the incubator 24, the operator touches the selection touch switch 96B on the password screen 96A and enters his / her password. When input, it was made possible to handle only the No1 incubator 24 designated by the worker. However, as another mode, the administrator may manage all of the incubator 24 and the work contents that the administrator causes the operator to work. For example, when the administrator causes the operator to perform subculture work on the cells cultured in the No. 1 incubator 24, the cell identification registration number (incubator) assigned to each cell managed by the plurality of incubators 24. The cell identification registration number corresponding to the No. 1 incubator 24 is input to the selection touch switch 96B. Thereby, the lock unit 38 of only the No1 incubator 24 is unlocked. Also, by entering the cell identification registration number, work details such as “culture”, “process inspection”, “passage”, “maintenance”, etc. are displayed on the password screen 96A. When the person inputs his / her password to the selection touch switch 96B, the person touches the “passage” part, which is the work content given by the administrator. As a result, the No. 1 pilot lamp among the No. 1 to No. 4 pilot lamps (PL) 106 of the central control panel 13 is turned on, and the push button of the lock unit 38 corresponding to the No. 1 incubator 24 in the culture work chamber 12. The lamp 54 is turned on. If the operator touches the display of the wrong work content, neither the pilot lamp nor the push button lamp 54 of the lock unit 38 is lit. The operation after A in FIG. 10 is the same.

  Therefore, when entering the culture work chamber 12, the operator can recognize without inaccuracy which lock unit 38 of the incubator 24 should be handled, and what to enter when entering the culture work chamber 12. Can recognize whether or not

  As described above, even when the management system of the present invention is adopted and operated as described above, a plurality of medical thermostats with different specifications depending on the manufacturer and model are provided in the test room for integrated management. In addition, it is possible to easily construct a system for reliably preventing cell mistakes and cross contamination.

  In the present embodiment, the example of the four incubators 24 has been described.

A sketch of a cell preparation room incorporating the medical thermostatic management system of the present invention Overall view when four lock units are provided for each of the four units provided in the culture chamber Explanatory drawing explaining the structure of a manual type lock unit Explanatory drawing explaining the locking and unlocking mechanism of the lock arm Explanatory drawing of the slide mechanism provided in the lock unit Illustration of centralized control panel Explanatory drawing when the lock unit is provided on the hinge side of the incubator Explanatory drawing explaining structure of automatic type lock unit Overall view when four automatic units are installed in the incubation chamber The flowchart figure explaining the operation | movement step of the management system of the medical thermostat of this invention. The flowchart figure explaining the operation | movement step of the management system of the medical thermostat of this invention following the flowchart of FIG.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 ... Cell preparation room, 12 ... Culture work room, 13 ... Central control board, 14 ... Changing room, 16 ... Dressing room, 22 ... Clean bench, 24 ... Incubator, 26 ... Centrifuge, 28 ... Work table, 30 ... inverted phase contrast microscope, 38 ... manual type lock unit, 40 ... support frame, 42 ... lock arm, 44 ... lock means, 46 ... lock arm position confirmation sensor, 48 ... door open / close confirmation sensor, 50 ... alarm, 52 ... Push button lamp for alarm, 54 ... Push button lamp with switch means and display means together, 56 ... Post, 58 ... Connecting rod, 60 ... Floor surface, 62 ... Ceiling surface, 64 ... Hinge, 66 ... Swing Arm, 68 ... device box, 70 ... swing support mechanism, 72 ... L-shaped member, 74 ... support bar, 76 ... pin, 78 ... rail, 80 ... linear bearing, 82 ... mounting base. 84 ... Rail, 86 ... Linear bearing, 88 ... Slide base, 90 ... Rail, 92 ... Linear bearing, 94 ... Relay terminal box, 96 ... Touch panel, 96A ... Password input screen, 96B ... Selection touch switch display, 97 ... Confirmation display 98 ... Select switch key, 100 ... Key hole, 102 ... Select lever, 104 ... Push button lamp for power supply, 106 ... Pilot lamp, 110 ... Automatic lock unit, 112 ... Drive means, 112A ... Rotary solenoid, 112B ... Biasing means 113 ... Notch 114 ... Equipment box 116 ... Rotating shaft 118 ... Bearing 120 ... Cylindrical member (bush)

Claims (13)

In the management system for medical thermostats, which have multiple medical thermostats in the test chamber and each medical thermostat handles different samples,
By providing a lock unit for managing the opening and closing of the door for each medical thermostat on a support frame standing on the floor of the test chamber, the lock unit is provided separately from the medical thermostat. This is a medical thermostat management system.   2. The medical thermostat management system according to claim 1, wherein the test chamber is a culture work chamber that performs work related to cell culture as the sample, and the medical thermostat is an incubator. 3. The lock unit is
A lock arm in which the door of the medical thermostat cannot be opened and a lock arm that is movable to an open position that can be opened;
Lock means for locking the lock arm in the lock position;
Switch means for releasing the lock of the locking means;
3. The medical thermostatic management system according to claim 1, further comprising display means for displaying permission to open the door. The lock unit is
A lock arm in which the door of the medical thermostat cannot be opened and a lock arm that is movable to an open position that can be opened;
Drive means for moving the lock arm between the lock position and the open position;
Switch means for turning on and off the drive means;
3. The medical thermostatic management system according to claim 1, further comprising display means for displaying permission to open the door.   5. The medical thermostatic management system according to claim 3, further comprising a lock arm position confirmation sensor for confirming whether the lock arm is in the locked position or the open position. In the lock unit,
The medical thermostat management system according to any one of claims 3 to 5, further comprising a door open / close confirmation sensor for checking whether the door of the medical thermostat is in an open state or a closed state.   The medical thermostat according to any one of claims 3 to 6, wherein the switch means and the display means are configured as one means by a push button lamp which is turned on when the switch is pressed. Management system.   The support frame is provided with a plurality of the lock units, and the plurality of lock units are individually provided with a slide mechanism that slides in at least one of the vertical direction, the width direction, and the depth direction of the medical thermostat. The medical thermostat management system according to any one of claims 1 to 7.   The medical thermostat management system according to any one of claims 3 to 8, wherein the display means of the lock unit is displayed by a signal from a central control panel provided outside the culture work room. .   10. The medical device according to claim 9, wherein the central control panel is provided with an operator specifying mechanism for specifying one worker for each of a plurality of medical thermostats provided in the test chamber. Thermostat management system.   11. The medical thermostatic management system according to claim 10, wherein the operator specifying mechanism is double management of password management and barcode management.   The medical thermostatic management system according to any one of claims 1 to 11, wherein the support frame also serves as a gantry on which the medical thermostatic chamber is placed.   13. The lock unit according to any one of claims 3 to 12, wherein the lock unit is provided with alarm means for sounding an alarm when the timer means operates in conjunction with the activation of the switch means and the time is up. Medical thermostat management system.

Images