201208711 六、發明說明： 【發明所屬之技術領域】 本發明係關於-種皮膚化妝品。進而詳細而言，關於一 種皮膚化妝品，其藉由調配D-胺基酸或者其衍生物或其趟 及β·丙胺酸衍生物’而具有抑制毛孔之料狀結構突出^ . 丨孔縮小效果，防止、改善由不飽和脂肪酸引起之肌膚粗 糖之效果，及皮膚之皺紋、彈性改善效果，並且使用性 (無黏膩感、滋潤度、彈性感）亦優異。 【先前技術】 肌膚粗糙係由於乾燥、紫外線、清潔劑或化學物質等刺 激性物質等外在重要因素，或激素平衡之奈亂等内在重要 因素而產生之肌膚困擾，並伴隨角質層屏障功能之下降、 角質層水分量之下降、表皮代謝回轉之完進、鱗屑之產生 (鱗肩，scaling)而角質粗糙化等現象。尤其角質之粗糙 化，亦有時使妝面服帖變差，成為很多女性美容方面之煩 惱。 先前，為改善肌膚粗糙，可使用藉由凡士林軟膏或油中 水型礼化製劑等閉塞劑而彌補角質層屏障功能的方法，藉 •&山梨糖醇或甘油、環氧烷衍生物等保濕劑而補充角質層 水分置的方法，藉由甘草次酸等消炎藥而消解皮膚炎症的 方法藉由維生素、激素等而活化皮膚細胞的方法（參照 專利文獻1〜5)。 然而，如上所述之先前方法有如下缺點：其任一者之皮 膚水刀保持此力均不充分，不僅角質改善效果較少，尤其 156750.doc 201208711 使用閉塞劑之情形時較為油腻，帶來黏糊糊等令人不快之 觸感。另-方面，於使用保濕劑之情形時亦為提高效果而 必須大量調配’其結果為，有帶來黏糊糊感或滑腻感等令 人不快之觸感的問題。進而，於使用胎盤等動物組織之萃 取物或維生素、激素等之情形時，於與副作用等相關之安 全佳或時穩定性方面有問題。尤其，關於角質粗縫化， 角質之剝離未順利地進行之狀況已明確，但並無適當之對 策。 又，人之肌膚由於季節變動或年齡增加而易於產生表現 為毛孔之大出或肌膚粗糙、鬆弛或皺紋等種種煩惱。近年 尤八以年輕女性為中心，對於毛孔之突出之煩惱增 大，必需有改善該煩惱之皮膚外用組合物。然而毛孔突出 之機制並不明確，現在，通常應對為收斂化妝水或去除角 栓。常常，亦較多以粉底實現改善外觀。 J而，例如收斂化妝水之目的在於收縮肌膚，原因在於 藉由醇暫時降低皮膚表面溫度，或藉由有機酸等使蛋白質 凝固之作用。因此由於為暫時收縮肌膚者，&而對皮膚之 負擔較大又無法根本解決毛孔之突出，其效果亦不充分。 先刖，亦有乙醇酸或抗壞血酸衍生物具有毛孔縮小效果之 報告（例如，參照非專利文獻υ，但其作用機制或效果之程 度等尚不明確之方面亦較多。 又，角栓去除係物理性去除阻塞毛孔之角栓之方法，例 如提出利用含有具有鹽生成基之高分子化合物的角栓去除 劑（專利文獻6)、含有水不溶性環糊精聚合物之化妝品（專 156750.doc 201208711 利文獻7)、含有5Gf量％以上黏度為5〜8()之油 分的角栓去除用化妝品（專利文獻8)等之去除。 ’、、:而該種去除角栓之方法中，亦有時物理性力對肌膚 造成損傷，或彳時對皮膚之副作用&為問冑。又亦有時其 效果亦為暫時而角栓立馬再生，或若去除角栓則使毛孔變 大，效果未必充分。 進而已知β-丙胺酸衍生物係作為對皮膚之有效成分而自 先前起調配於化妝品中，通常，若於化妝品中調配β_丙胺 酸衍生物則獲得滋潤度。關於該種ρ_丙胺酸衍生物之化妝 品調配記載於專利文獻9中，顯示ρ_丙胺酸衍生物具有皮 膚之角化不全抑制作用、毛孔縮小效果、肌膚粗糙改善、 防止效果等。然而，於使用上述卜丙胺酸衍生物之情形 時，發現皮膚之毛孔縮小效果、肌膚粗糙改善、防止效 果’然而並未充分發現皺紋、彈性之改善效果。 [先前技術文獻] [專利文獻] [專利文獻1]日本專利特開平6-293625號公報 [專利文獻2]曰本專利特開平7_277943號公報 [專利文獻3]曰本專利特開平9_9543 2號公報 [專利文獻4]曰本專利第366〇656號公報 [專利文獻5]曰本專利特開2〇〇9_227645號公報 [專利文獻6]曰本專利特開平5 — 97627號公報 [專利文獻7]曰本專利特開平5· 105619號公報 [專利文獻8]曰本專利特開2〇〇2_24丨260號公報 156750.doc 201208711 [專利文獻9]曰本專利特開2006-3 12597號公報 [非專利文獻] [非專利文獻1]矢況慶史等，Fragrance Journal，2002 年，第30卷，第2號，p54〜58 【發明内容】 [發明所欲解決之問題] 本發明係鑒於上述課題而完成者，其目的在於提供一種 皮膚化妝品，其具有綜合性地改善毛孔縮小、肌膚粗链防 止、改善等功能及皺紋、彈性之改善效果的效果，且使用 性亦優異。 [解決問題之技術手段] 本發明者等為解決上述課題而反覆進行努力研究，結果 發現藉由調配D-胺基酸及β丙胺酸衍生物，可獲得毛孔縮 小、肌膚粗糙防止、改善等效果優異’可改善肌膚之皺 紋、彈性，並且使用性亦優異的皮膚化妝品；從而完成本 發明。 即’本發明提供一種含有（A)D_胺基酸、其衍生物及/或 鹽之1種或2種以上，及（Β)β_丙胺酸衍生物及其鹽之丨種或2 種以上的皮膚化妝品。 [發明之效果] 本發明之皮膚化妝品藉由將成分（八)〇_胺基酸或其衍生 物及/或鹽之1種或2種以上及成分（Β)ρ丙胺酸衍生物及其 鹽之1種或2種以上併用，而具有綜合性地改善角化不全抑 制、毛孔縮小、肌膚粗糙防止、改善等功能及皺紋、彈性 156750.doc 201208711 之改善效果的有利效果，並且使用性亦優異。 【實施方式】 ' 以下，對本發明進行詳細敍述。 本發明之皮膚化妝品必須含有〇_胺基酸、其衍生物及/ 或鹽之1種或2種以上（(A)成分：以下有時省略為「D_胺基 酸類」）。 如眾所周知，胺基酸十作為光學異構物而存在L體及D 體，天然之蛋白質為L-胺基酸進行肽結合者。一般認為， 除了細菌之細胞壁等一部分例外之外，於以人為代表之哺 乳類之體内僅存在L-胺基酸，生體僅利用L_胺基酸。因此 先前，學術上或產業上引人注目而經研究之胺基酸僅為^ 胺基酸。 作為例外地使用D-胺基酸之事例，可列舉：（丨）作為細 菌中產生之抗生素之原料之情形，（2)含有於在化學合成胺 基酸時為節省自等量獲得之L-胺基酸與0_胺基酸混合物 (消旋體）僅分取L-胺基酸的成本而直接作為DL_胺基酸混 合物而調配的食品添加物中之情形等。 最近’已明瞭人類隨著年齡增加，原本應該不存在於眼 之晶狀體、腦、或者皮膚等中之D_天冬醯胺酸（D_Asp，D_ Asparaginic Acid)增加，對其與白内障或阿茲海默症之發 病之關係等已進行討論（木野内忠稔等，「蛋白質核酸 酶」第50卷’第5號（2005年）453-560頁）。於皮膚中亦發現 由於老化或紫外線照射而累積有D-Asp，提出將D-Asp作 為用以識別老化或紫外線引起之皮膚損傷的分子標記物而 156750.doc 201208711 應用（藤井紀子，美容研究報告，第13號（2〇〇5年）。然而， 未知將D·胺基酸積極地用作生理活性物質的例子。 本發明之特徵在於如下方面：將先前由於如上所述之情 況而未調配於化妝品尤其皮膚化妝品中的D_胺基酸作為必 需成分而調配。 本發明中使用之D-胺基酸類（(A)成分）只要為〇體則並無 特別限定，但較佳為其本身確認有肌膚改善效果者。具體 而言，可列舉確認有抗氧化效果、膠原蛋白產生促進效果 之D-天冬醯胺酸’確認有層黏連蛋白332產生促進效果、 膠原蛋白產生促進效果之D_丙胺酸，確認有屏障恢復功 能、敵紋形成減輕效果、肌膚粗糙減輕效果之^縠胺酸， 確認有紫外線損傷減輕效果之D-絲胺酸，確認有層黏連蛋 白3 32產生促進效果之D-羥基脯胺酸，確認有紫外線損傷 減輕效果之D-半胱胺酸，確認有紫外線損傷減輕效果之〇_ 甲硫胺酸及D-脯胺酸，確認有黑色素生成抑制效果之d—經 基脯胺酸等。 本發明中使用之D-胺基酸類可為合成者亦可為市售品。 作為D-胺基酸之製造方法，例如已知使源自細菌之〇_胺 基醯化酶作用於醯化胺基酸而獲得之方法等（參照日本專 利特開平11-113592號公報）。 本發明之皮膚化妝品中之D-胺基酸類的調配量相對於化 妝品總量較佳為0· 1〜5·0質量％。於未達〇. 1質量％時，獲得 作為本發明之特徵之無黏腻感、肌膚改善效果優異之化妝 品較為困難，即便調配5.0質量％亦無法獲得作為本發明之 156750.doc 201208711 效果之肌膚改善效果之進一步增強。 繼而對作為本發明之另一必需成分的卜丙胺酸衍生物或 其鹽（成分（B))進行詳細敍述。 作為本發明中使用之成分（B)之β-丙胺酸衍生物，只要 為可用於化妝品者則並無特別限定，例如可列舉：3 (ιι_ 哌啶）-丙酸、β-丙胺酸醢胺、Ν_單甲基丙胺酸、Ν_環己 基-β-丙胺酸、Ν-環己基甲基_β_丙胺酸、Ν_環己基_Ν_曱 基-β-丙胺酸、Ν-環己基羰基_β_丙胺酸、Ν_(2,_吡啶基）_ρ_ 丙胺酸、Ν-菸鹼醯基_|3_丙胺酸、Ν_节氧基羰基-卜丙胺 酸、Ν-苄基·β-丙胺酸、Ν_苯磺醯基—卜丙胺酸、ν_苯甲醯 基-β-丙胺酸、Ν-對大茴香甲醯基_β_丙胺酸（]^_4,_甲氧基苯 曱醯基-β-丙胺酸）' Ν_間大茴香甲醯基—p·丙胺酸（N-3i_甲 氧基苯甲醯基·β-丙胺酸）、Ν_鄰大茴香曱醯基丙胺酸 (Ν-2'-曱氧基苯曱醯基_β_丙胺酸）、Ν·3,，4，，5，_三甲氧基苯 甲醯基-β-丙胺酸、Ν_苯基乙醯基_p_丙胺酸、或者該等之 鹽等。其中，就藥劑穩定性、及對皮膚之效果方面而言， 最佳為3-(1’-d底啶）_丙酸或者其鹽。 作為β丙胺酸衍生物之鹽，例如可列舉：鹼金屬鹽（鈉 鹽、鉀鹽、鋰鹽等）、鹼土類金屬鹽（鈣鹽、鎂鹽等广銨 鹽、有機胺鹽（單乙醇胺鹽、二乙醇胺鹽、三乙醇胺鹽等） 等。（Β)成分可使用1種或2種以上。 本發明之皮膚化妝品中之β·丙胺酸衍生物（成分的調 配量較佳為於本發明之皮膚化妝品中設為〇1〜5 〇質量％。 亦認為，於未達(U質量％時，有效果表現不充分之情形， 156750.doc 201208711 即便調配超過5.0質量％，本發明之效果亦並不進一步增 強，且於穩定性方面出現影響。 本發月之皮膚化妝品中，可根據需要而適當調配通常化 妝品或醫藥品等皮膚外用劑中使用之成分，例>:油分、 界面活性劑、粉末、色料、水、醇類、增黏劑、整合劑、 聚石夕氧類、氧化防止劑（抗氧化劑）、紫外線吸收劑、保濕 齊J香料、各種藥效成分、防腐劑、中和劑、整劑等 任意調配成分。 上述任意調配成分中，作為油分之具體例，例如可列 舉路4油、茶樹油、龜油、澳洲胡桃油、玉米油、紹 油、撖欖油、菜籽油、蛋黃油、芝麻油、桃仁油、小麥胚 芽油山余化油、蓖麻油、亞麻仁油、紅花子油、棉籽 油、月見草油、紫蘇油、大豆油、花生油、茶軒油、樞子 由米糠/由、/包桐油、日本桐油、荷荷爸油、胚芽油、三 甘油、二辛酸甘油g旨、三異掠冑酸甘油醋等液體油脂，可 可油月曰、椰子油、馬油、氫化椰子油、棕搁油、牛油、羊 油、虱化牛油、棕櫚核油、豬油、木蠟核;由、氫化油、木 躐、氫化E麻油等固體油脂，蜂蠛、堪地里拉躐、巴西栋 櫚堰、羊毛脂、乙酸羊毛脂、液狀羊毛脂、甘㈣、羊毛 脂脂肪酸異丙醋、月桂酸己醋、還原羊毛月旨、荷荷包蠟、 硬質羊毛脂、聚氧乙婦（以下稱為P〇E(pQly()xyethylene))羊 毛醇_、POE羊毛醇乙酸s旨、羊毛脂脂肪酸聚乙二醇、 POE氫化羊毛醇醚等蠟類，液態石蠟、地蠟、角鯊烯、石 蠟地壤、角農院、凡士林、微晶壤等煙，肉豆鐘酸異丙 156750.doc 201208711 醋、辛酸十六烷基酯、肉豆蔻酸辛基十二烷基酯、棕櫊酸 異丙酯、硬脂酸丁酯、月桂酸己酯、肉豆蔻酸肉豆蔻酯、 油酸癸酯、二曱基辛酸己基癸酯、乳酸十六烷基酯、乳酸 肉豆蔻酯、乙酸羊毛脂、硬脂酸異十六烷基酯、異硬脂酸 異十六烷基酯、12-羥基硬脂酸膽固醇酯、二（2_乙基己酸） 乙二醇酯、二季戊四醇脂肪酸酯、單異硬脂酸N_烷二醇 酯、新戊二醇二癸酸酯、蘋果酸二異硬脂酯、二（2_庚基十 一烷酸）甘油酯、三（2-乙基己酸）三羥曱基丙烷、三異硬脂 酸三羥甲基丙烷、四（2-乙基己酸）季戊四醇酯、三（2_乙基 己酸）甘油酯、三異硬脂酸三羥曱基丙烷、十六烷基_2_乙 基己酸酯、標櫚酸2 -乙基己酯、三肉豆蔬酸甘油醋、三（2_ 庚基十一烷酸）甘油酯、蓖麻油脂肪酸曱酯、油酸油酯、 乙醯甘油酯、棕櫚酸-2-庚基十一烧基酯、己二酸二異丙 酯、N-月桂醯基-L-穀胺酸-2·辛基十二烷基酯、己二酸二 (2-庚基十一烷基酯）、癸二酸二（2_乙基己酯）、肉豆蔻酸· 2-己基癸酯、稼糊酸-2-己基癸酯、己二酸己基癸酯、 癸二酸二異丙酯、琥珀酸-2-乙基己酯等酯油，月桂酸、肉 豆蔻酸、棕櫚酸、硬脂酸、山蓊酸、油酸、丨2_羥基硬脂 酸、十一碳烯酸、羊毛脂脂肪酸、異硬脂酸、亞麻油酸、 次亞麻油酸、二十碳五烯酸等高級脂肪酸，月桂醇、十六 烷醇、硬脂醇、山荼醇、肉豆蔻帛、油醇、鯨蠟硬脂醇、 單硬脂基甘油醚（I肝醇）、2_癸基十四烷醇、羊毛醇、膽 固醇、植固醇、己基十二烷醇、異硬脂醇、辛基十二烷醇 等直鏈、支鏈高級醇，=甲基聚矽氧烷、甲基苯基聚矽氧 156750.doc 201208711 烷等聚矽氧油，全氟己烷、三全氟-正丁基胺等全氟碳乃 至全氟聚醚等。 作為界面活性劑，例如可列舉：皂用原料、月桂酸鈉、 棕搁酸鈉等脂肪酸皂，月桂基硫酸鈉、月桂基硫酸卸等高 級烷基硫酸酯鹽，POE月桂基硫酸三乙醇胺、p〇E月桂基 硫酸鈉等烷基醚硫酸酯鹽，月桂醯基肌胺酸鈉等^醯基肌 胺酸’ N-肉豆蔻醯基·Ν_甲基牛磺酸鈉、椰子油脂肪酸曱 基牛"®if自*_納專南級脂肪酸酿胺績酸鹽，ρ〇Ε十八烧基趟罐 酸醋等磷酸酯鹽’單月桂醯基單乙醇醯胺POE磺基號珀酸 鈉、月桂基聚丙二醇磺基琥珀酸鈉等磺基琥珀酸鹽，直鏈 十二烧基苯項酸鈉、直鏈十二烧基苯續酸三乙醇胺等院基 苯磺酸鹽，N-硬脂醯基穀胺酸二鈉、N_硬脂醯基榖胺酸單 鈉等N-醯基穀胺酸鹽，氫化椰子油脂肪酸甘油硫酸鈉等高 級脂肪酸酯硫酸酯鹽，土耳其紅油等硫酸化油，POE烧基 喊羧酸’ POE烧基稀丙基喊緩酸鹽，高級脂肪酸酯績酸 鹽，二級醇硫酸酯鹽，高級脂肪酸烷基醇酿胺基硫酸酯 鹽’月桂酿基早乙醇酿胺破ίό酸納，路蛋白納等陰離子系 界面活性劑；硬脂基三甲基氣化銨、月桂基三甲基氯化銨 等烷基三曱基銨鹽，二硬脂基二曱基氣化銨鹽等二烷基二 曱基敍鹽，西°比氣铵等燒基》比錠鏽鹽，烧基四級敍鹽，烧 基二甲基~基敍鹽’烷基異喧琳鏽鹽，二烧基七υ尔二々 厶鹽，ΡΟΕ烷基胺，烷基胺鹽，聚胺基脂肪酸衍生物，戊 酵脂.肪酸衍生物，氣化苯甲烴銨等陽離子系界面活性劑； 2-挪油酿基-2 -β米唾琳錄虱氧化物緩基乙氧基二納鹽等 156750.doc 12 201208711 本Μ兩性界面活性劑’酿胺基甜 、 甜菜鹼系界面^料 ^甜菜鹼等 酸酯、山祖μ ▲ 性劑；山梨糖醇酐單油 t ^糖_單異硬脂酸自旨、山梨糖料單月桂酸 西曰、山梨糖醇酐單棕櫚酸酉旨、山梨糖醇酐三油酸g|等山梨 糖醇酐脂肪酸酿類’單棉籽油脂肪酸甘油醋、單硬脂酸甘 油酿、倍半油酸甘油醋、單硬脂酸甘油酯蘋果酸踏等甘、、由 聚甘油脂肪酸輯類，單硬脂酸丙二醇等丙二醇脂肪酸醋 類，虱化！麻油衍生物，甘油烧基謎，p〇E_f基聚石夕氧烧 共聚物等親油性非離子性界面活㈣；pQE山梨糖醇肝單 油酸醋' POE山梨糖醇酐單硬脂酸醋等p〇E山梨糖醇肝脂 肪酸醋類’ PGE山㈣醇單月桂_旨、pQE山梨糖醇單油 酸醋、POE山梨糖醇單硬脂酸醋等p〇E山梨糖醇脂肪酸酯 類，POE甘油單油酸酯、P0E甘油二硬脂酸酯等p〇E甘油 脂肪酸醋類，POE單油酸酯、p0E二硬脂酸酯、poE單二 油酸醋等POE脂肪酸酯類，POE月桂醚、poE油醚、poE 二氫膽固醇酯等POE烷基醚類，poe辛基苯基醚、poE壬 基本基醚荨POE烧基苯基趟類，POE-聚氧化丙稀（以下稱 為 POP(Polyoxypropylene))單 丁醚、ρ〇Ε·ρ〇ρ 十六院基 醚、ΡΟΕ-ΡΟΡ甘油醚等ΡΟΕ-ΡΟΡ烷基醚類，ροε葱麻油、 ΡΟΕ氫化蓖麻油、ΡΟΕ氫化蓖麻油單異硬脂酸酯、ροε氫 化蓖麻油馬來酸酯等ΡΟΕ蓖麻油氫化蓖麻油衍生物，ΡΟΕ 山梨糖醇蜂蠟等ΡΟΕ蜂蠟-羊毛脂衍生物，椰子油脂肪酸二 乙醇醯胺、脂肪酸異丙醇醯胺等院醇醯胺，ΡΟΕ丙二醇脂 肪酸酯，ΡΟΕ脂肪酸醯胺’ ΡΟΕ烷基胺，蔗糖脂肪酸酯， 156750.doc •13· 201208711 烧基乙氧基一甲基胺基氧化物等親水性非離子性界面活性 劑等。 作為粉末，例如可列舉：雲母、滑石、高嶺土、絹雲母 (sencite)、白雲母、金雲母、合成雲母、紅雲母黑雲 母氧化鋰雲母、合成雲母、碳酸鈣、碳酸鎂、矽酸野 (二氧化矽）、矽酸鋁、矽酸鋇、矽酸鈣、矽酸鎂、矽酸 錄、氧化紹、顧鋇、鐵丹、黃氧化鐵、黑氧化鐵、氧化 始群月普魯士藍、氧化鈦、氧化鋅、雲母鈦（含氧化 欽之雲母）、天_珠質、氧基氣化Μ、氮化删、紅色228 號紅色226號、藍色4〇4號、聚乙婦粉末、聚甲基丙稀酸 曱醋粉末、聚酿胺樹月旨粉末（尼龍粉末）、纖維素粉末、有 機聚矽氧烷彈性體、鋁粉、銅粉等。 作為醇類，例如可列舉：甲醇、乙醇、丙醇、異丙醇等 低級醇；膽固醇、榖留醇、羊毛留醇等。 作為增黏劑，例如可列舉：阿拉伯膠、黃蓍膠、半乳 糖、角豆英膠、瓜爾膠、鹿角菜膠、果膠、璦脂、澱粉 (玉米、小麥、馬鈴薯、米)等植物系高分子，葡聚糖、普 魯_等微生物系高分子，缓甲基殿粉、甲基經基丙基 澱粉等澱粉系高分子，膠原蛋白、酪蛋白、明膠等動物系 问'刀子’甲基纖維素、確基纖維素、乙基纖維素、經乙基 纖維素、纖維素硫酸鈉、經基丙基纖維素1曱基纖維 素、結晶纖維素等纖維素系高分子，海藻酸鈉、海藻酸丙 二醇醋等海藻酸系高分子’ ％乙烯基甲趟、緩乙烯聚合物 等乙烯系高分子’ Ρ〇Μ高分子，簡聚氧化丙稀共聚物 156750.doc 201208711 系高分子，聚丙烯酸鈉、聚丙烯酸醯胺等烷系高分子，聚 乙烯亞胺、陽離子聚合物、膨潤土、矽酸鋁鎂、合成鋰皂 石、鋰蒙脫石、矽酸酐等無機系水溶性高分子等水溶性高 分子等。 作為螯合劑’例如可列舉：檸蘋酸、傘菌酸、甘油酸、 莽草酸、檜木醇、沒食子酸、丹寧酸、咖啡酸、乙烯二胺 四乙酸、乙二醇二胺四乙酸、二乙稀三胺五乙酸、非丁 酸、聚磷酸、偏磷酸、以及該等之類似物以及該等之鹼金 屬鹽及羧酸酯等。 作為紫外線吸枚劑，例如可列舉：對胺苯曱酸等苯曱酸 系紫外線吸收劑；鄰胺苯曱酸曱酯等鄰胺苯曱酸系紫外線 吸收劑；水楊酸辛酯等水揚酸系紫外線吸收劑；對曱氧基 桂皮酸異丙醋、對甲氧基桂皮酸辛酯等桂皮酸系紫外線吸 收劑；尿刊酸、尿刊酸乙酯等紫外線吸收劑。 作為保濕劑’例如可列舉：聚乙二醇（以下稱為 PEG(Polyethylene glyC〇l))、丙二醇、二丙二醇、13_丁二 醇、甘油、二甘油、木糖醇、麥芽糖醇、麥芽糖、D_甘露 醇、葡萄糖、果糖、硫酸軟骨素鈉、玻尿酸鈉、乳酸鈉、 葡萄糖胺、環糊精等。 作為藥效成分’例如可調配：維生素A油、視黃醇、棕 櫚酸視黃醇、鹽酸吡哆醇、煙鹼酸节酯、煙鹼酸醯胺、煙 驗酸dl-α-生育酚、抗壞血酸磷酸鎂、維生素、dl-α-生育 酴、泛酸、生物素等維生素類；奠、甘草甜素等消炎藥； 熊果苷等美白劑；雌二醇等激素類；氧化鋅、丹寧酸等收 156750.doc -15- 201208711 斂劑；L-薄荷腦、樟腦等清涼劑；其他氣化溶菌酶、鹽酸 吡哆醇、硫等。進而可調配顯示多種藥效之各種萃取物。 即，可列舉.魚腥草萃取物、黃柏萃取物、甘草萃取物、 芍藥萃取物、杜丹皮萃取物、絲瓜萃取物、虎耳草萃取 物、桉樹萃取物、丁香萃取物、七葉樹萃取物、矢車菊萃 取物、海藻萃取物、百里香萃取物等。 作為防腐劑，例如可列舉：苯甲酸 '水楊酸、對羥基笨 甲酸醋（對羥苯甲酸曱醋、對羥笨曱酸乙醋、對羥笨^酸 丁酯等）、山梨酸、對氯間甲酚、六氣酚、氣化苯甲烴 銨、氣化雙氣苯雙胍己啶、三氯碳醯代雙胺苯、感光素、 苯氧基乙醇等。 此外，可於本發明之製劑中調配：2_胺基_2曱基-卜丙 醇、2-胺基-2-甲基-W丙二醇、氫氧化鉀、氫氧化卸、三 乙醇胺、碳酸鈉等中和劑；乳酸、檸檬酸、乙醇酸、琥珀 酸、酒石酸、蘋果酸、碳酸氫鈉、碳酸氫銨等ρΗ值調整 劑；抗壞血酸、α-生育酚、胡蘿蔔素等抗氧化劑。 再者’上述成分為例示’並不限定於該等。又該等成分 可依據根據所需之形態之配方而適當組合並調配。 作為本發明之皮膚化妝品之劑型，可選取水溶液系、可 溶化系、乳化系、油液系、凝膠系、軟膏系、喷霧系、 水-油2層系、水-油-粉末3層系等廣泛之劑型。 藉由使用以本發明為基礎之角化不全㈣劑、毛孔縮小 劑、肌膚_止、改善劑、皮膚外用組合物等組合物， 可提供-種皮膚化妝品，其抑制角化不全使肌膚狀態維持 156750.doc -16- 201208711 良好之狀態，又改盖，报士、4 w °形成改善皺紋、彈性之肌膚。 本發明之乳化皮膚化此σ π & ^ 、 贗匕妝°°可藉由如下常法而獲得：預先 、•備由相水相’-面於以此方式製備之水相中缓緩添加 相 面藉由混合.撥拌等使其乳化等，但其製法並不 非限定於該等例示。 >本發明之皮膚化妝品較佳地作為乳化粉底或防曬乳液等 乳液狀製品、或潤膚霜等霜狀製品而提供。 [實施例] 以下列舉實施例對本發明進而具體地進行說明，但本發 明不受該等任何限制。再者，只要未特別標記調配量均為 質量％。 首先，對本實施例中使用之試驗方法、評價方法進行說 明。 <確認試驗1及2>人毛孔縮小效果 使用健康男性之臉頰部，以各群5人進行丨個月lg2次塗 佈試樣之實驗。 首先，將本發明品與比較品各塗佈半張臉。於塗佈連用 刖及連用後取印模’並以三維雷射掃描顯微鏡觀察同一部 位毛孔之形狀變化。毛孔之大小係藉由視覺判定以1〜1 3之 13等級（數字越大毛孔越大）而評價（確認試驗丨），算出塗佈 則後之評分差（塗佈後一塗佈前）’將其作為印模判定值（續 認試驗2)，並研究各試樣之有效性。 <確認試驗3〜7>使用性、敵紋改善效果及肌膚之彈性感 對各s式驗品’讓檢查貝10人使用，並對使用性（確認試 156750.doc 17 201208711 驗3)、連用2週後之皺紋改善效果（確認試驗4)、連用4週後 之皺紋改善效果（確認試驗5)、連用2週後之彈性感.肌膚感 到彈性之使用感（確認試驗6)、及連用4週後之彈性感.肌膚 感到彈性之使用感（確認試驗7)進行判定，並以如下之基準 進行評價。 <確認試驗3>使用性（使用時無黏腻感） ◎:感覺無黏腻感之人為8人以上 〇：感覺無黏膩感之人為5人〜7人 △:感覺無黏腻感之人為3人~4人 x:感覺無黏腻感之人為2人以下 <確認試驗4>連用2週後之皺紋改善效果 ◎:感覺有皺紋改善效果之人為8人以上 〇：感覺有皺紋改善效果之人為5人〜7人 △:感覺有皺紋改善效果之人為3人〜4人 x:感覺有皺紋改善效果之人為2人以下 <確認試驗5>連用4週後之皺紋改善效果 ◎:感覺有皺紋改善效果之人為8人以上 〇：感覺有皺紋改善效果之人為5人~7人 △:感覺有皺紋改善效果之人為3人~4人 x :感覺有皺紋改善效果之人為2人以下 <確認試驗6>連用2週後之彈性感.肌膚感到彈性之使用感 ◎:感覺有皺紋改善效果之人為8人以上 〇：感覺有皺紋改善效果之人為5人〜7人 △:感覺有皺紋改善效果之人為3人〜4人 156750.doc -18 - 201208711 x:感覺有皺紋改善效果之人為2人以下 <確認試驗7>連用4週後之彈性感·肌膚感到彈性之使用感 ◎:感覺有彈性改善效果之人為8人以上 〇：感覺有彈性改善效果之人為5人〜7人 △:感覺有彈性改善效果之人為3人〜4人 x :感覺有彈性改善效果之人為2人以下 實施例1〜10及比較例1 ~ 1 〇 以下述表1〜4中所示之組成藉由常法製造作為皮膚化妝 品之護膚霜’並依據上述確認試驗丨〜7之評價方法.基準進 行評價。將結果分別示表1〜4中。 [表1] 實施例 成分名 1 2 3 4 5 (1)2-乙基己酸十六烷基酯 2 2 2 2 2 (2)液態石蠟 2 2 2 2 2 (3)十曱基環戊矽氧烷 5 5 5 5 5 (4)荷荷芭油 1 1 1 1 1 (5)POE(21)十八烷基醚 2 2 2 2 2 (6)POE(2)十八烷基醚 0.5 0.5 0.5 0.5 0.5 (7)十六醇 2.5 2.5 2.5 2.5 2.5 ⑻肝醇 1 1 1 1 1 (9)香料 0.1 0.1 0.1 0.1 0.1 (10)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 (11)1，3-丁二醇 4 4 4 4 4 (12)成分(B)3-(r-哌咬)-丙酸 0.1 1 3 5 1 (13)成分(B)N-環己基曱基-β-丙胺酸 2 (14)成分(A)D-丙胺酸 0.1 1 3 5 2.5 (15)成分(A)D-天冬醯胺酸 2.5 (16)對羥苯甲酸酯 0.1 0.1 0.1 0.1 0.1 156750.doc •19- 201208711 實施例 成分名 1 2 3 4 5 (17)乙醇 3 3 3 3 3 (18)苯氧基乙醇 0.3 0.3 0.3 0.3 0.3 (19)(乙烯基°比咯烷酮/丙烯醯基二甲基牛磺 酸銨)共聚物 0.5 0.5 0.5 0.5 0.5 (20)檸檬酸 0.07 0.07 0.07 0.07 0.07 (21)檸檬酸鈉 0.03 0.03 0.03 0.03 0.03 <確認試驗1>視覺判定值(5人之平均） 1.7 1.4 1 1.1 1.2 〈確認試驗2>人毛孔縮小效果（印模判定 值，5人之平均） -0.1 -0.3 -0.5 -1.5 -1.2 <確認試驗3>使用性(使用時之黏腻感） ◎ ◎ ◎ ◎ ◎ 認試驗4>連用2週後之皺紋改善效果 〇 〇 ◎ ◎ ◎ <確認試驗5>連用4週後之皺紋改善效果 〇 ◎ ◎ ◎ ◎ <確認試驗6>連用2週後之彈性感·皮膚感到 彈性之使用感 〇 ◎ ◎ ◎ ◎ <確認試驗7>連用4週後之彈性感·皮膚感到 彈性之使用感 〇 ◎ ◎ ◎ ◎ [表2] 實施例 成分名 6 7 8 9 10 (1)2-乙基己酸十六院基醋 2 2 2 2 2 (2)液態石蝶 2 2 2 2 2 (3)十曱基環戊矽氧烷 5 5 5 5 5 (4)荷荷芭油 1 1 1 1 1 (5)ΡΟΕ(21)十八烷基醚 2 2 2 2 2 ⑹ΡΟΕ(2)十八烷基醚 0.5 0.5 0.5 0.5 0.5 (7)十六醇 2.5 2.5 2.5 2.5 2.5 ⑻輩、肝醇 1 1 1 1 1 (9)香料 0.1 0.1 0.1 0.1 0.1 (10)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 (11)1,3-丁二醇 4 4 4 4 4 (12)成分(Β)3-(Γ-哌啶)-丙酸 - - - - 2.5 156750.doc -20- 201208711 實施例 成分名 6 7 8 9 10 (13)成分(B)N-環己基甲基-β-丙胺酸 0.1 2 4 5 • (14)成分(A)D-丙胺酸 • - 0.5 1.5 2 (15)成分(A)D-天冬醯胺酸 0.1 5 0.5 1.5 3 (16)對羥苯曱酸酯 0.1 0.1 0.1 0.1 0.1 (17)乙醇 3 3 3 3 3 (18)苯氧基乙醇 0.3 0.3 0.3 0.3 0.3 (19)(乙烯基》比咯烷酮/丙烯醯基二甲基牛磺 酸銨)共聚物 0.5 0.5 0.5 0.5 0.5 (20)檸檬酸 0.07 0.07 0.07 0.07 0.07 (21)檸檬酸鈉 0.03 0.03 0.03 0.03 0.03 <確認試驗1>視覺判定值(5人之平均） 1.6 1.4 1.1 1.1 1.2 <確認試驗2>人毛孔縮小效果(印模判定值， 5人之平均） -0.2 -0.4 -0.5 -0.7 -0.8 <確認試驗3>使用性(使用時之黏膩感） ◎ ◎ ◎ ◎ ◎ 認試驗4>連用2週後之皺紋改善效果 〇 〇 ◎ ◎ ◎ <確認試驗5>連用4週後之皺紋改善效果 〇 ◎ ◎ ◎ ◎ <確認試驗6>連用2週後之彈性感·皮膚感到 彈性之使用感 〇 ◎ ◎ ◎ ◎ <確認試驗7>連用4週後之彈性感·皮膚感到 彈性之使用感 〇 ◎ ◎ ◎ ◎ [表3] 比較例 成分名 1 2 3 4 5 (1)2-乙基己酸十六烷基酯 2 2 2 2 2 (2)液態石躐 2 2 2 2 2 (3)十甲基環戊矽氧烷 5 5 5 5 5 (4)荷荷芭油 1 1 1 1 1 (5)POE(21)十八烷基醚 2 2 2 2 2 (6)POE(2)十八烷基醚 0.5 0.5 0.5 0.5 0.5 (7)十六醇 2.5 2.5 2.5 2.5 2.5 ⑻策肝醇 1 1 1 1 1 156750.doc -21 · 201208711201208711 VI. Description of the Invention: TECHNICAL FIELD OF THE INVENTION The present invention relates to a skin cosmetic. Further, in detail, a skin cosmetic having a material-like structure for inhibiting pores by blending D-amino acid or a derivative thereof or a hydrazine and a β-alanine derivative thereof. It is excellent in the effect of preventing and improving the skin's raw sugar caused by unsaturated fatty acids, the wrinkles and elasticity of the skin, and the usability (no stickiness, moisturizing, and elastic feeling). [Prior Art] Rough skin is caused by external factors such as dryness, ultraviolet rays, detergents, chemicals, and other irritating substances, or internal factors such as hormone balance, and the stratum corneum barrier function. Decreased, decreased water content in the stratum corneum, complete conversion of epidermal metabolism, scaling (scaling) and keratin roughening. In particular, the roughening of the horny skin sometimes makes the makeup face worse, which has become an annoyance for many women's beauty. Previously, in order to improve the roughness of the skin, a method of making up the barrier function of the stratum corneum by using an occlusive agent such as a vaseline ointment or an oil-based ritual preparation can be used to moisturize the sorbitol or glycerin or an alkylene oxide derivative. A method of replenishing the moisture in the stratum corneum, and a method of activating skin cells by vitamins, hormones, or the like by a method for reducing skin inflammation by an anti-inflammatory drug such as glycyrrhetinic acid (see Patent Documents 1 to 5). However, the prior method as described above has the following disadvantages: the skin water knife of either of them has insufficient force to maintain this force, and not only the keratin improvement effect is small, especially 156750.doc 201208711 The use of an occlusive agent is relatively greasy, bringing Slimy and other unpleasant touches. On the other hand, in the case of using a humectant, it is necessary to increase the effect in order to improve the effect. The result is that there is a problem of an unpleasant touch such as a sticky feeling or a slippery feeling. Further, when an extract of animal tissues such as a placenta, vitamins, hormones or the like is used, there is a problem in terms of safety or stability in connection with side effects and the like. In particular, regarding the keratin roughening, the situation in which the keratin peeling has not proceeded smoothly has been clarified, but there is no appropriate countermeasure. In addition, human skin is prone to various problems such as large pores or rough, loose or wrinkled skin due to seasonal changes or age. In recent years, Yuba is centered on young women, and it is necessary to have a skin external composition for improving the troubles of the pores. However, the mechanism by which the pores protrude is not clear. Now, it is usually the case to converge the lotion or remove the angle plug. Often, more foundations are used to improve the appearance. Further, for example, the purpose of astringent lotion is to shrink the skin because the alcohol temporarily lowers the surface temperature of the skin, or the protein is coagulated by an organic acid or the like. Therefore, since the skin is temporarily contracted, and the burden on the skin is large, the protrusion of the pores cannot be fundamentally solved, and the effect is insufficient. First, there are reports that the glycolic acid or ascorbic acid derivatives have a pore-shrinking effect (for example, refer to the non-patent literature, but the degree of action mechanism or effect is still unclear. A method of physically removing a plug which blocks a pore, for example, a corner plug removing agent containing a polymer compound having a salt generating group (Patent Document 6) and a cosmetic containing a water-insoluble cyclodextrin polymer (Specially 156750.doc 201208711) (7), the removal of a cosmetic for removing angle plugs (Patent Document 8) containing 5 parts by weight or more and an oil content of 5 to 8 (), and the like. When the physical force causes damage to the skin, or when it is rubbed, it is a side effect of the skin. Sometimes the effect is temporary and the angle is immediately regenerated, or if the angle plug is removed, the pores become larger, and the effect may not be Further, it is known that a β-alanine derivative is formulated into a cosmetic as an active ingredient for the skin, and usually, if a β-alanine derivative is formulated in a cosmetic, it is moisturized. The cosmetic preparation of the ρ-alanine derivative is described in Patent Document 9, and it is shown that the ρ-alanine derivative has a skin keratosis inhibitory effect, a pore reduction effect, an improvement in skin roughness, an anti-effect, and the like. When the above-mentioned amphetamine derivative is used, it is found that the pores of the skin are reduced, the skin roughness is improved, and the effect is prevented. However, the effect of wrinkles and elasticity is not sufficiently found. [Prior Art Literature] [Patent Literature] [Patent Literature] Japanese Patent Laid-Open No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. [Patent Document 5] Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. No. Hei. [Patent Document 8] 曰 专利 特 〇〇 〇〇 _ _ _ 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 156 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012庆庆史, et al., Fragrance Journal, 2002, Vol. 30, No. 2, p54~58 [Summary of the Invention] The present invention has been made in view of the above problems, and an object thereof is to provide a skin cosmetic product. In addition, it has an effect of comprehensively improving the function of reducing pores, preventing and improving the skin, and improving the wrinkles and elasticity, and is excellent in usability. [Technical means for solving the problem] The present inventors have solved the above problems. In an effort to study, it has been found that by blending D-amino acid and beta alanine derivative, it is possible to obtain an effect of reducing pores, preventing rough skin, and improving the skin's wrinkles and elasticity, and excellent useability. Skin cosmetics; thus completing the present invention. That is, the present invention provides one or two or more kinds of (A) D-amino acids, derivatives and/or salts thereof, and (Β)β-alanine derivatives and salts thereof. Above skin cosmetics. [Effects of the Invention] The skin cosmetic of the present invention comprises one or more of the component (octa)-amino acid or a derivative thereof and/or a salt thereof, and a component (Β) p-alanine derivative and a salt thereof. It is used in combination with one or more of them, and has an advantageous effect of comprehensively improving the effects of parakeratosis, pore reduction, skin roughness prevention, improvement, wrinkles, and elasticity 156750.doc 201208711, and is excellent in usability. . [Embodiment] Hereinafter, the present invention will be described in detail. The skin cosmetic of the present invention must contain one or two or more kinds of hydrazine-amino acids, derivatives and/or salts thereof ((A) component: hereinafter, it may be omitted as "D_amino acid"). As is well known, amino acid is present as an optical isomer and L and D are present, and the natural protein is an L-amino acid for peptide binding. It is generally considered that, except for a part of the cell wall of bacteria, there is only L-amino acid in the body of a human-represented mammal, and the organism uses only L-amino acid. Therefore, previously, the academically or industrially strikingly studied amino acid was only an amino acid. As an example of the use of the D-amino acid as an exception, (2) is used as a raw material of an antibiotic produced in bacteria, and (2) is contained in a chemically synthesized amino acid to save an equivalent amount of L- The case where the amino acid mixture and the 0-amino acid mixture (racemic body) are only used for the cost of the L-amino acid and are directly formulated as a DL_amino acid mixture, and the like. Recently, it has been known that with the increase of age, D_Asp, D_Asparaginic Acid, which should not exist in the lens, brain, or skin of the eye, increases with cataract or Azhai. The relationship between the onset of morbidity and the like has been discussed (Muye Nai, et al., Protein Nucleases, Vol. 50, No. 5 (2005), pp. 453-560). It is also found in the skin that D-Asp is accumulated due to aging or ultraviolet irradiation, and D-Asp is proposed as a molecular marker for identifying skin damage caused by aging or ultraviolet rays. 156750.doc 201208711 Application (Fuji Kiko, Beauty Research Report , No. 13 (2〇〇5 years). However, an example in which D-amino acid is actively used as a physiologically active substance is unknown. The present invention is characterized by the following aspects: it is not previously formulated due to the situation as described above. D-amino acid in cosmetics, especially skin cosmetics, is formulated as an essential component. The D-amino acid (component (A)) used in the present invention is not particularly limited as long as it is a steroid, but it is preferably itself. It is confirmed that there is a skin-improving effect. Specifically, D-aspartic acid which has an antioxidant effect and a collagen production-promoting effect is confirmed to have a laminin 332 production promoting effect and a collagen production promoting effect. D_alanine, which confirms the function of barrier recovery, the effect of reducing the formation of enemies, and the effect of reducing the skin roughness, and confirming the effect of UV damage reduction. D-hydroxyproline which has a promoting effect on laminin 3 32 was confirmed, and D-cysteine which has a UV-damaging effect was confirmed, and it was confirmed that there was an effect of reducing ultraviolet damage _ methionine and D- The d-amino acid which is used in the present invention may be a synthon or a commercially available product. The method for producing D-amino acid For example, a method in which a bacterium-derived hydrazine-deuterated enzyme derived from bacteria is used to act on a deuterated amino acid is known (refer to Japanese Laid-Open Patent Publication No. Hei 11-113592). The amount of the amino acid to be added is preferably from 0.1 to 5.0% by mass based on the total amount of the cosmetic. When it is less than 0.1% by mass, the non-sticky feeling and the skin improving effect which are characteristics of the present invention are obtained. The cosmetic is difficult, and even if it is formulated in an amount of 5.0% by mass, the skin-improving effect of the effect of 156750.doc 201208711 of the present invention is not further enhanced. Then, the amphetamine derivative or a salt thereof which is another essential component of the present invention ( Ingredient (B)) The β-alanine derivative which is the component (B) used in the present invention is not particularly limited as long as it can be used for cosmetics, and examples thereof include: 3 (ιι_ piperidine)-propionic acid, β- Amidyl amide, Ν_monomethylalanine, Ν_cyclohexyl-β-alanine, Ν-cyclohexylmethyl _β-alanine, Ν_cyclohexyl Ν 曱 曱 --β-alanine, Ν-cyclohexylcarbonyl _β_alanine, Ν_(2,_pyridyl)_ρ_ alanine, Ν-nicotinyl __|3_alanine, Ν_ oxycarbonyl- amphetamine, Ν-benzyl ·β-alanine, Ν_phenylsulfonyl- amphetamine, ν_benzylidene-β-alanine, Ν-p-anionyl 醯β_alanine (]^_4,_A Oxyphenylhydrazino-β-alanine)' Ν_Between fennel formazan-p-alanine (N-3i_methoxybenzylidene-β-alanine), Ν_- Mercaptoalanine (Ν-2'-nonyloxyphenylhydrazone_β_alanine), Ν·3,,4,5,3-trimethoxybenzimidyl-β-alanine, hydrazine _Phenylethyl hydrazine _p_alanine, or such salts. Among them, 3-(1'-d-endridinyl)-propionic acid or a salt thereof is preferred in terms of stability of the drug and effect on the skin. Examples of the salt of the beta alanine derivative include an alkali metal salt (sodium salt, potassium salt, lithium salt, etc.), an alkaline earth metal salt (a calcium salt, a magnesium salt, and the like, a broad ammonium salt, an organic amine salt (monoethanolamine salt). (1) or a combination of two or more kinds of (Β) components. The β-alanine derivative in the skin cosmetic of the present invention (the amount of the component is preferably in the present invention) In the case of skin cosmetics, it is considered to be 〇1 to 5 〇% by mass. It is also considered that when it is not reached (U mass %, there is insufficient effect, 156750.doc 201208711 even if the blending exceeds 5.0% by mass, the effect of the present invention is It is not further enhanced, and it has an effect on the stability. In the skin cosmetics of this month, the ingredients used in external skin preparations such as cosmetics or pharmaceuticals can be appropriately formulated as needed, for example: oil, surfactant, Powders, pigments, water, alcohols, tackifiers, integrators, polyoxin, oxidation inhibitors (antioxidants), UV absorbers, moisturizers, various medicinal ingredients, preservatives, neutralization Agent Any of the above-mentioned optional components, as a specific example of the oil component, for example, road 4 oil, tea tree oil, turtle oil, Australian walnut oil, corn oil, Shaoyou oil, eucalyptus oil, rapeseed oil, Egg butter, sesame oil, peach kernel oil, wheat germ oil mountain remnant oil, castor oil, linseed oil, safflower oil, cottonseed oil, evening primrose oil, perilla oil, soybean oil, peanut oil, tea Xuan oil, pivot from rice bran / by , / Bao Tong oil, Japanese tung oil, jojo oil, germ oil, triglycerin, dicapry glycerol g, three different glycerin vinegar and other liquid fat, cocoa butter, coconut oil, horse oil, hydrogenated coconut oil , palm oil, butter, sheep oil, eucalyptus butter, palm kernel oil, lard, wood wax core; solid oils such as hydrogenated oil, hibiscus, hydrogenated E sesame oil, bee stings, candidum, Brazilian terracotta, lanolin, lanolin acetate, liquid lanolin, glycerol (tetra), lanolin fatty acid isopropyl vinegar, lauric acid vinegar, reduced wool scent, jojo wax, hard lanolin, polyoxymethylene ( Hereinafter referred to as P〇E(pQly()xyethylene)) sheep Maolin _, POE lanolin acetic acid s, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin ether and other waxes, liquid paraffin, ceresin, squalene, paraffin, soil, agro-forest, petrolatum, microcrystalline Smoke such as soil, isopropyl acid 156750.doc 201208711 vinegar, cetyl octanoate, octyl dodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate , myristate myristate, decyl oleate, hexyl decyl decyl octoate, cetyl lactate, myristyl lactate, lanolin acetate, isohexadecyl stearate, isostearyl Isohexadecyl acid ester, cholesterol ester of 12-hydroxystearic acid, ethylene glycol di(2-ethylhexanoate), fatty acid ester of dipentaerythritol, N-alkylene glycol monoisostearate, new Pentanediol dicaprate, diisostearyl malate, bis(2-heptylundecanoic acid) glyceride, tris(2-ethylhexanoic acid) trihydroxydecylpropane, triisostearic acid Trimethylolpropane, tetrakis(2-ethylhexanoate) pentaerythritol ester, tris(2-ethylhexanoic acid) glyceride, triisostearate triisostearate, cetyl _2 _ethylhexanoate, 2-ethylhexyl palmitate, tri-glycine glycerin, tris(2-deheptanodecanoic acid) glyceride, castor oil fatty acid oxime ester, oleic acid ester, B Glycerol glyceride, palmitic acid-2-heptyl eldecyl ester, diisopropyl adipate, N-lauryl-L-glutamic acid-2·octyldodecyl ester, adipic acid Bis(2-heptylundecyl ester), di(2-ethylhexyl) sebacate, 2-hexyldecyl myristate, 2-hexyldecyl methacrylate, hexyl adipate Ester ester, diisopropyl sebacate, 2-ethylhexyl succinate and other ester oils, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 丨2_hydroxyl hard Higher fatty acids such as fatty acid, undecylenic acid, lanolin fatty acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid, lauryl alcohol, cetyl alcohol, stearyl alcohol, mountain Sterol, nutmeg, oleyl alcohol, cetearyl alcohol, monostearyl glyceryl ether (I heparin), 2_decyltetradecyl alcohol, lanolin, cholesterol, phytol, hexyldodecane Straight chain, such as alcohol, isostearyl alcohol, octyldodecanol Chain higher alcohol, = methyl polyoxyalkylene, methyl phenyl polyoxyl 156750.doc 201208711 alkane and other polyoxygenated oils, perfluorohexane, tri-perfluoro-n-butylamine and other perfluorocarbons or even perfluorinated Polyether and so on. Examples of the surfactant include a fatty acid soap such as a raw material for soap, sodium laurate or sodium brown sodium, a higher alkyl sulfate salt such as sodium lauryl sulfate or lauryl sulfate, and POE lauryl sulfate triethanolamine.烷基E alkyl ether sulfate such as sodium lauryl sulfate, sodium lauryl sarcosinate, etc. 'N-myristyl Ν 甲基 methyl tauroate, coconut oil fatty acid sulfhydryl Cow "®if self-*_纳南南 fatty acid-based amine salt, ρ〇Ε18-based 趟 趟 acid vinegar and other phosphate esters 'monolaurin monoethanolamine POE sulfoyl sodium Sulfuccisuccinates such as lauryl polyglycol sulfosuccinate, phthalic acid benzene sulfonate such as linear decyl benzoate, linear decyl benzoic acid triethanolamine, N-hard N-mercaptoglutamine such as lipoyl glutamate disodium, N-stearyl decyl glutamate monosodium, hydrogenated coconut oil fatty acid glycerol sulfate, etc., higher fatty acid ester sulfate, Turkish red oil, etc. Sulfated oil, POE-based carboxylic acid 'POE-based propyl sulphonate, higher fatty acid ester acid salt, secondary alcohol sulfate , higher fatty acid alkyl alcohol sulphate sulphate salt 'laurel brewing base early ethanol tyrosine sulphate sodium, sulphate nano anionic surfactant; stearyl trimethyl ammonium hydride, lauryl trimethyl An alkyltrimethylammonium salt such as ammonium chloride, a dialkyldifluorenyl salt such as a distearyldiamine vaporized ammonium salt, a sulphur-based salt such as a sulphur-based ammonium salt, and a sulphur-based salt Grade salt, alkyl dimethyl-based salt, alkyl sulfonium salt, dialkyl sulfoxide salt, decylamine, alkylamine salt, polyamine fatty acid derivative,戊 脂 fat. Fatty acid derivatives, gasification of benzalkonium chloride and other cationic surfactants; 2-Nan oil brewing base-2 -β rice salivary oxide oxide slow-group ethoxy di-nano salt 156750. Doc 12 201208711 Bismuth surfactant intercalating agent 'branched amine sweet, betaine interface material ^ betaines and other acid esters, sylvestre ▲ agent; sorbitan mono oil t ^ sugar _ monoisostearic acid Self-purpose, sorbose monocropalate, sorbitan monopalmitate, sorbitan trioleate, etc., sorbitol fatty acid brewing type 'single cottonseed oil fatty acid Glycerine vinegar, glycerin monostearate, sesquioleic acid glycerin vinegar, glyceryl monostearate, malic acid, etc., glycerol fatty acid vinegar such as polyglycerol fatty acid, glycerol monostearate, etc. ! Sesame oil derivative, glycerin-burning mystery, p〇E_f-based polyoxo-oxygenated copolymer and other lipophilic nonionic interfacial activities (4); pQE sorbitol liver monooleic acid vinegar 'POE sorbitan monostearate Such as p〇E sorbitol liver fatty acid vinegar 'PGE mountain (four) alcohol single laurel _ purpose, pQE sorbitol monooleic acid vinegar, POE sorbitol monostearic acid vinegar and other p〇E sorbitol fatty acid esters, POE glycerol monooleate, P0E glyceryl distearate such as p〇E glycerin fatty acid vinegar, POE monooleate, p0E distearate, poE mono-oleic acid vinegar and other POE fatty acid esters, POE laurel POE alkyl ethers such as ether, poE oil ether, poE dihydrocholesterol ester, poe octyl phenyl ether, poE 壬 basic ether oxime POE alkyl phenyl hydrazine, POE-polyoxypropylene (hereinafter referred to as POP) (Polyoxypropylene)) 丁-ΡΟΡ alkyl ethers such as monobutyl ether, ρ〇Ε·ρ〇ρ hexadecane ether, ΡΟΕ-ΡΟΡ glyceryl ether, ροε onion oil, hydrazine hydrogenated castor oil, hydrazine hydrogenated castor oil Castor oil hydrogenated castor oil derivatives such as stearate, ροε hydrogenated castor oil maleate, sorbitol beeswax, etc. ΟΕ beeswax-lanolin derivative, coconut oil fatty acid diethanolamine, fatty acid isopropanolamine, etc., propylene glycol fatty acid ester, hydrazine fatty acid guanamine 'nonylamine, sucrose fatty acid ester, 156750 .doc •13· 201208711 Hydrophilic nonionic surfactants such as ethoxylated monomethylamino oxide. Examples of the powder include mica, talc, kaolin, sencite, muscovite, phlogopite, synthetic mica, phlogopite, mica, mica, mica, calcium carbonate, magnesium carbonate, and sulphuric acid. Cerium oxide), aluminum citrate, barium strontium citrate, calcium citrate, magnesium citrate, strontium sulphate, oxidized sulphate, sulphate, iron sulphate, yellow iron oxide, black iron oxide, oxidized group, Prussian blue, titanium oxide , zinc oxide, mica titanium (including oxidized medlar), celestial enamel, oxycarburic hydrazine, nitriding, red 228 red 226, blue 4 〇 4, poly ethoxy powder, poly Acrylic acid vinegar powder, polystyrene tree powder (nylon powder), cellulose powder, organic polyoxyalkylene elastomer, aluminum powder, copper powder, and the like. Examples of the alcohols include lower alcohols such as methanol, ethanol, propanol and isopropanol; cholesterol, sterol alcohol, and lanolin alcohol. Examples of the tackifier include acacia, tragacanth, galactose, carob gum, guar gum, carrageenan, pectin, rouge, starch (corn, wheat, potato, rice) and the like. It is a macromolecular polymer such as a polymer, a dextran or a Plu _, a starch-based polymer such as a slow methyl methacrylate powder or a methyl propyl propyl starch, and an animal such as collagen, casein or gelatin. Cellulose-based polymer such as methyl cellulose, cellulose, ethyl cellulose, ethyl cellulose, sodium cellulose sulfate, propyl cellulose, fluorenyl cellulose, crystalline cellulose, alginic acid Alginic acid-based polymer such as sodium or alginate propylene glycol vinegar '% vinyl formazan, vinyl polymer such as vinyl polymer' Ρ〇Μ polymer, simple polyoxypropylene copolymer 156750.doc 201208711 polymer, An alkane polymer such as sodium polyacrylate or polyacrylamide, an inorganic water-soluble polymer such as polyethyleneimine, a cationic polymer, bentonite, aluminum magnesium silicate, laponite, hectorite or phthalic anhydride. Water soluble polymer, etc. Examples of the chelating agent include citramalic acid, agaric acid, glyceric acid, shikimic acid, eucalyptus, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, and ethylene glycol diamine tetraacetic acid. , diethylenetriamine pentaacetic acid, non-butyric acid, polyphosphoric acid, metaphosphoric acid, and the like, and the alkali metal salts and carboxylic acid esters thereof. Examples of the ultraviolet absorbing agent include a benzoic acid-based ultraviolet absorbing agent such as imiprofen acid, an o-amine benzoic acid-based ultraviolet absorbing agent such as phthalic acid phthalic acid ester, and salicylic acid such as octyl salicylate. It is a UV absorber; a cinnamic acid-based ultraviolet absorber such as methoxy cinnamic acid isopropyl vinegar or p-methoxy cinnamic acid octyl ester; a UV absorber such as urinary acid or urinary acid ethyl ester. Examples of the humectant include polyethylene glycol (hereinafter referred to as PEG (Polyethylene Gly C)), propylene glycol, dipropylene glycol, 13-butanediol, glycerin, diglycerin, xylitol, maltitol, maltose, and the like. D_mannitol, glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, cyclodextrin, and the like. As a medicinal ingredient, for example, it can be adjusted: vitamin A oil, retinol, retinyl palmitate, pyridoxine hydrochloride, nicotinic acid glutamine, nicotinic acid amide, niacin acid dl-α-tocopherol, Ascorbyl magnesium phosphate, vitamins, dl-α-tocopherol, pantothenic acid, biotin and other vitamins; anti-inflammatory drugs such as molybdenum, glycyrrhizin; leucoside and other whitening agents; estradiol and other hormones; zinc oxide, tannic acid Wait 156750.doc -15- 201208711 to collect agents; L-menthol, camphor and other cooling agents; other gasification lysozyme, pyridoxine hydrochloride, sulfur and so on. Further, various extracts exhibiting various pharmacological effects can be adjusted. That is, Houttuynia cordata extract, Cork extract, licorice extract, peony extract, Dudan peel extract, loofah extract, Saxifrage extract, eucalyptus extract, clove extract, horse chestnut Extract, cornflower extract, seaweed extract, thyme extract, etc. Examples of the preservative include benzoic acid 'salicylic acid, p-hydroxy benzoic acid vinegar (p-hydroxybenzoic acid vinegar, p-hydroxy hydroxy acetoacetate, hydroxy hydroxy butyl acrylate, etc.), sorbic acid, and the like. Chloro-m-cresol, hexa- phenol, gasified benzalkonium chloride, gasified double gas benzodiazepine, trichlorocarbon bismuth benzene, photoreceptor, phenoxyethanol, and the like. In addition, it can be formulated in the preparation of the invention: 2-amino-2-mercapto-propanol, 2-amino-2-methyl-W propanediol, potassium hydroxide, hydrogen hydroxide, triethanolamine, sodium carbonate Neutralizers; lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium bicarbonate, ammonium bicarbonate and other ρΗ value adjusters; ascorbic acid, α-tocopherol, carotene and other antioxidants. Further, 'the above components are exemplified' and are not limited to these. Further, the ingredients may be appropriately combined and formulated according to the formulation according to the desired form. As a dosage form of the skin cosmetic of the present invention, an aqueous solution, a solubilized system, an emulsified system, an oil system, a gel system, an ointment system, a spray system, a water-oil 2-layer system, and a water-oil-powder layer can be selected. A wide range of dosage forms. By using a composition according to the present invention, such as a keratolytic agent (four) agent, a pore reducing agent, a skin-stopping agent, an improving agent, and a skin external composition, a skin cosmetic can be provided which inhibits parakeratosis and maintains skin condition. 156750.doc -16- 201208711 Good condition, changed again, the priest, 4 w ° to form wrinkles, elastic skin. The emulsified skin of the present invention, σ π & ^, 赝匕 ° ° ° can be obtained by the following conventional methods: pre-, prepared from the phase of the water phase - surface in the water phase prepared in this way slowly added The surface is emulsified by mixing, mixing, etc., but the preparation method is not limited to the examples. > The skin cosmetic of the present invention is preferably provided as a creamy product such as an emulsified foundation or a sunscreen lotion, or a creamy product such as a moisturizer. [Examples] Hereinafter, the present invention will be specifically described by way of examples, but the present invention is not limited thereto. Further, as long as the amount of the coating is not particularly marked, the mass% is %. First, the test method and evaluation method used in the present embodiment will be described. <Confirmation test 1 and 2> Human pore reduction effect Using the cheek portion of a healthy male, an experiment was conducted in which 5% of the samples were applied for 丨2 times in each group. First, the present invention and the comparative product were each coated with a half face. The coating was taken after coating and splicing, and the shape of the same pore was observed by a three-dimensional laser scanning microscope. The size of the pores was evaluated by visual judgment with a scale of 1 to 13 (the larger the number is, the larger the pores were) (confirmation test 丨), and the difference in score after coating (before coating after coating) was calculated. This was taken as the impression judgment value (continuation test 2), and the validity of each sample was examined. <Confirmation test 3 to 7> Usability, the effect of improving the enemy's texture, and the elasticity of the skin. For each s-type test, 'use the tester 10 people for use, and useability (confirmation test 156750.doc 17 201208711 test 3), Wrinkle improvement effect after 2 weeks of use (confirmation test 4), wrinkle improvement effect after 4 weeks of use (confirmation test 5), elasticity after 2 weeks of use, skin feeling of elasticity (confirmation test 6), and use The feeling of elasticity after 4 weeks, the feeling of use of the skin feeling elastic (confirmation test 7) was judged, and it evaluated based on the following. <Confirmation test 3> Usability (no sticky feeling when used) ◎: A person who feels no sticky feeling is 8 or more people: A person who feels no sticky feeling is 5 to 7 people △: Feel no sticky feeling 3 persons to 4 people x: People who feel no sticky feeling are 2 or less <Confirmation test 4> Wrinkle improvement effect after 2 weeks of use ◎: People who feel wrinkle improvement effect are 8 or more people: Feeling wrinkles improvement The effect is 5 to 7 people △: The person who feels the wrinkle improvement effect is 3 to 4 people x: The person who feels the wrinkle improvement effect is 2 or less. <Confirmation test 5> Wrinkle improvement effect after 4 weeks of use ◎: There are more than 8 people who feel the effect of wrinkle improvement. The person who feels the effect of wrinkle improvement is 5 to 7 people. △: The person who feels the effect of wrinkle improvement is 3 to 4 people x: The person who feels the effect of wrinkle improvement is 2 or less. <Confirmation test 6> The elasticity of the skin after 2 weeks of use. The feeling of the skin feeling elastic ◎: The person who feels the wrinkle improvement effect is 8 or more people: The person who feels the wrinkle improvement effect is 5 to 7 people △: Feeling The effect of wrinkle improvement is 3 to 4 people 156750.doc -18 - 2 01208711 x: The person who feels the effect of wrinkle improvement is 2 or less. <Confirmation test 7> The feeling of elasticity after 4 weeks of use and the feeling of elasticity of the skin ◎: The person who feels the elasticity improvement effect is 8 or more people: Feeling flexible The number of people who have improved the effect is 5 to 7 people. △: The person who feels the effect of improving the elasticity is 3 to 4 people. x: The person who feels the effect of improving the elasticity is 2 persons. The following examples 1 to 10 and the comparative examples 1 to 1 are as follows. The composition shown in 1 to 4 was produced by a conventional method as a skin cream for skin cosmetics, and was evaluated based on the evaluation method of the above-mentioned confirmation test 丨7. The results are shown in Tables 1 to 4, respectively. [Table 1] Example ingredient name 1 2 3 4 5 (1) Cetyl 2-ethylhexanoate 2 2 2 2 2 (2) Liquid paraffin 2 2 2 2 2 (3) Decamethylcyclopentane Oxane 5 5 5 5 5 (4) Jojoba Oil 1 1 1 1 1 (5) POE (21) octadecyl ether 2 2 2 2 2 (6) POE (2) octadecyl ether 0.5 0.5 0.5 0.5 0.5 (7) Cetyl alcohol 2.5 2.5 2.5 2.5 2.5 (8) Liver alcohol 1 1 1 1 1 (9) Perfume 0.1 0.1 0.1 0.1 0.1 (10) Ion exchange water remaining residual remaining surplus (11) 1,3- Butanediol 4 4 4 4 4 (12) Ingredients (B) 3-(r-piperiding)-propionic acid 0.1 1 3 5 1 (13) Ingredients (B) N-cyclohexyldecyl-β-alanine 2 (14) Ingredients (A) D-alanine 0.1 1 3 5 2.5 (15) Ingredients (A) D-aspartic acid 2.5 (16) paraben 0.1 0.1 0.1 0.1 0.1 156750.doc •19 - 201208711 EXAMPLES Ingredient name 1 2 3 4 5 (17) Ethanol 3 3 3 3 3 (18) Phenoxyethanol 0.3 0.3 0.3 0.3 0.3 (19) (Vinyl ° pyrrolidone / acryl dimethyl dimethyl Ammonium Taurate Copolymer 0.5 0.5 0.5 0.5 0.5 (20) Citric Acid 0.07 0.07 0.07 0.07 0.07 (21) Sodium Citrate 0.03 0.03 0.03 0.03 0.03 <Confirmation Test 1> Visual Judgment Value (5 person level)均) 1.7 1.4 1 1.1 1.2 <Confirmation test 2> Human pore reduction effect (imprint determination value, average of 5 people) -0.1 -0.3 -0.5 -1.5 -1.2 <Confirmation test 3> Usability (adhesive when used) ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ The feeling of elasticity after 2 weeks of use and the feeling of elasticity of the skin 〇 ◎ ◎ ◎ ◎ <Confirmation test 7> The feeling of elasticity after 4 weeks of use and the feeling of elasticity of the skin 〇 ◎ ◎ ◎ ◎ [Table 2] Example Ingredient name 6 7 8 9 10 (1) 2-ethylhexanoic acid 16 yards vinegar 2 2 2 2 2 (2) liquid stone butterfly 2 2 2 2 2 (3) decamethylcyclopentanoxane 5 5 5 5 5 (4) Jojoba oil 1 1 1 1 1 (5) ΡΟΕ (21) octadecyl ether 2 2 2 2 2 (6) ΡΟΕ (2) octadecyl ether 0.5 0.5 0.5 0.5 0.5 (7) Hexaol 2.5 2.5 2.5 2.5 2.5 (8) generation, hepatic alcohol 1 1 1 1 1 (9) perfume 0.1 0.1 0.1 0.1 0.1 (10) ion exchange water remaining remaining remaining surplus (11) 1,3-butanediol 4 4 4 4 4 (12) Ingredient (Β) 3-(Γ-piperidine)-propionic acid - - - - 2.5 156750.doc -20- 201208711 Example Ingredient name 6 7 8 9 10 (13) Ingredient (B) N-cyclohexyl Methyl-β-alanine 0.1 2 4 5 • (14) Ingredients (A) D-alanine • - 0.5 1.5 2 (15) Ingredients (A) D-aspartic acid 0.1 5 0.5 1.5 3 (16) p-Hydroxybenzoate 0.1 0.1 0.1 0.1 0.1 (17) Ethanol 3 3 3 3 3 (18) Phenoxyethanol 0.3 0.3 0.3 0.3 0.3 (19) (Vinyl) pyrrolidone / acryl dimethyl dimethyl Ammonium Taurate Copolymer 0.5 0.5 0.5 0.5 0.5 (20) Citric Acid 0.07 0.07 0.07 0.07 0.07 (21) Sodium Citrate 0.03 0.03 0.03 0.03 0.03 <Confirmation Test 1> Visual Judgment Value (Average of 5 Persons) 1.6 1.4 1.1 1.1 1.2 <Confirmation Test 2> Human pore reduction effect (impression judgment value, average of 5 persons) -0.2 -0.4 -0.5 -0.7 -0.8 <Confirmation test 3> Usability (sticky feeling when used) ◎ ◎ ◎ ◎ ◎ Test 4> Wrinkle improvement effect after 2 weeks of use ◎ ◎ ◎ <Confirmation test 5> Wrinkle improvement effect after 4 weeks of use ◎ ◎ ◎ ◎ <Confirmation test 6> For 2 weeks After the elasticity, skin Sense of use to elasticity ◎ ◎ ◎ ◎ <Confirmation test 7> The feeling of elasticity after 4 weeks of use and the feeling of elasticity of the skin 〇 ◎ ◎ ◎ ◎ [Table 3] Comparative example component name 1 2 3 4 5 (1 ) Cetyl 2-ethylhexanoate 2 2 2 2 2 (2) Liquid Dendrobium 2 2 2 2 2 (3) Decamethylcyclopentaoxane 5 5 5 5 5 (4) Jojoba Oil 1 1 1 1 1 (5) POE (21) octadecyl ether 2 2 2 2 2 (6) POE (2) octadecyl ether 0.5 0.5 0.5 0.5 0.5 (7) Cetyl alcohol 2.5 2.5 2.5 2.5 2.5 (8) Patricol 1 1 1 1 1 156750.doc -21 · 201208711
比較例 成分名 1 2 3 4 5 ⑼香料 0.1 0.1 0.1 0.1 0.1 (10)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 (11)1，3-丁二醇 4 4 4 4 4 (12)成分(Β)3-(Γ-哌咬)-丙酸 0.1 - 3 (13)成分(Β)Ν-環己基曱基-β-丙胺酸 - - - - (14)成分(A)D-丙胺酸 1 - 5 2.5 (15)成分(A)D-天冬醯胺酸 - • - 2.5 (16)對羥苯曱酸酯 0.1 0.1 0.1 0.1 0.1 (17)乙醇 3 3 3 3 3 (18)苯氧基乙醇 0.3 0.3 0.3 0.3 0.3 (19)(乙烯基。比咯烷酮/丙烯醯基二甲基牛磺 酸銨)共聚物 0.5 0.5 0.5 0.5 0.5 (20)檸檬酸 0.07 0.07 0.07 0.07 0.07 (21)檸檬酸鈉 0.03 0.03 0.03 0.03 0.03 <確認試驗1>視覺判定值(5人之平均） 1.7 1.9 1 1.7 1.5 <確認試驗2>人毛孔縮小效果(印模判定值， 5人之平均） 0.3 0.1 -1.2 0.2 -0.4 認試驗3>使用性(使用時之黏腻感） 〇 〇 X 〇 Δ 認試驗4>連用2週後之皺紋改善效果 Δ 〇 X ◎ Δ <確認試驗5>連用4週後之皺紋改善效果 X X X 〇 X <確認試驗6>連用2週後之彈性感·皮膚感到 彈性之使用感 X X X Δ Δ <確認試驗7>連用4週後之彈性感·皮膚感到 彈性之使用感 X Δ X 〇 XComparative Example Component Name 1 2 3 4 5 (9) Perfume 0.1 0.1 0.1 0.1 0.1 (10) Ion-exchanged water remaining remaining remaining remaining (11) 1,3-butanediol 4 4 4 4 4 (12) Component (Β) 3 -(Γ-piperider)-propionic acid 0.1 - 3 (13) Ingredients (Β)Ν-cyclohexyldecyl-β-alanine- - - - (14) Ingredients (A) D-alanine 1 - 5 2.5 (15) Ingredients (A) D-aspartic acid - • - 2.5 (16) p-hydroxybenzoate 0.1 0.1 0.1 0.1 0.1 (17) Ethanol 3 3 3 3 3 (18) Phenoxyethanol 0.3 0.3 0.3 0.3 0.3 (19) (Vinyl. Pyrrolidone / Acryldimethyldimethyltaurate) Copolymer 0.5 0.5 0.5 0.5 0.5 (20) Citric acid 0.07 0.07 0.07 0.07 0.07 (21) Sodium citrate 0.03 0.03 0.03 0.03 0.03 <Confirmation test 1> Visual judgment value (average of 5 persons) 1.7 1.9 1 1.7 1.5 <Confirmation test 2> Human pore reduction effect (impression judgment value, average of 5 persons) 0.3 0.1 -1.2 0.2 -0.4 Test 3> Usability (stickiness when using) 〇〇X 〇Δ Test 4> Wrinkle improvement effect after 2 weeks of use ΔX ◎ Δ <Confirmation test 5> Wrinkle after 4 weeks Improve performance XXX 〇X < (Confirmation test 6) The feeling of elasticity after 2 weeks of use and the feeling of use of skin feeling elasticity X X X Δ Δ <Confirmation test 7> The feeling of elasticity after 4 weeks of use and the feeling of elasticity of the skin feeling X Δ X 〇 X
[表4] 比較例 成分名 6 7 8 9 10 (1)2-乙基己酸十六烷基酯 2 2 2 2 2 (2)液態石蠟 2 2 2 2 2 (3)十甲基環戊矽氧烷 5 5 5 5 5 (4)荷荷芭油 1 1 1 1 1 •22- 156750.doc 201208711[Table 4] Comparative Example Ingredient name 6 7 8 9 10 (1) Cetyl 2-ethylhexanoate 2 2 2 2 2 (2) Liquid paraffin 2 2 2 2 2 (3) Decamethylcyclopentane Oxane 5 5 5 5 5 (4) Jojoba Oil 1 1 1 1 1 • 22- 156750.doc 201208711
比較例 成分名 6 7 8 9 10 (5)ΡΟΕ(21)十八烷基醚 2 2 2 2 2 (6)ΡΟΕ(2)十八烷基醚 0.5 0.5 0.5 0.5 0.5 (7)十六醇 2.5 2.5 2.5 2.5 2.5 ⑻装肝醇 1 1 1 1 1 (9)香料 0.1 0.1 0.1 0.1 0.1 (10)離子交換水 剩餘 剩餘 剩餘 剩餘 剩餘 (11)1,3-丁二醇 4 4 4 4 4 (12)成分(Β)3-(Γ-哌啶)-丙酸 _ - • (13)成分(Β)Ν-環己基曱基-β-丙胺酸 _ 2 4 5 _ (14)成分(A)D-丙胺酸 署 _ _ • _ (15)成分(A)D-天冬醯胺酸 0.1 _ _ (16)對羥苯曱酸酯 0.1 0.1 0.1 0.1 0.1 (17)乙醇 3 3 3 3 3 (18)苯氧基乙醇 0.3 0.3 0.3 0.3 0.3 (19)(乙烯基'比咯烷酮/丙烯醯基二曱基牛磺 酸銨)共聚物 0.5 0.5 0.5 0.5 0.5 (20)檸檬酸 0.07 0.07 0.07 0.07 0.07 (21)檸檬酸鈉 0.03 0.03 0.03 0.03 0.03 <確認試驗1>視覺判定值(5人之平均） 2 1.2 1.1 1.1 2 〈確認試驗2>人毛孔縮小效果（印模判定 值，5人之平均） 0.3 -0.4 -0.5 -0.7 0.2 <確認試驗3>使用性(使用時之黏腻感） X Δ 〇 Δ Δ <確認試驗4>連用2週後之皺紋改善效果 X 〇 Δ X X <確認試驗5>連用4週後之皺紋改善效果 Δ Δ X X X <確認試驗6>連用2週後之彈性感·皮膚感到 彈性之使用感 X X X X X <確認試驗7>連用4週後之彈性感·皮膚感到 彈性之使用感 Δ Δ X X X 根據表1〜4很清楚，含有作為本發明之必需成分之成分 (A) D-胺基酸、其衍生物及/或鹽之1種或2種以上及成分 (Β)β-丙胺酸衍生物及其鹽之1種或2種以上的本發明之實施 156750.doc -23- 201208711 例1〜1 ο，可提供一種使用性優異且毛孔縮小之效果及皺 紋、彈性改善效果優異之皮膚化妝品，但缺少本發明之必 需成分（Α)及（Β)—者或兩者之比較例1~10則缺少上述使用 性及毛孔縮小之效果、皺紋·彈性改善效果之任一者。 以下，進而例示本發明之其他實施例。 再者，亦對以下之實施例進行與上述相同之效果試驗， 結果均獲得優異之結果。 實施例11 :潤膚霜（0/W型（Oil in Water，水中油型）） 成分 調配量(質量％) (1) 硬脂醇 2.0 (2) 山蓊醇 1.0 (3) 氫化聚異丁烯 4.0 (4) 角鯊烧 7.0 (5) 二新戊酸三丙二醇 2.0 (6) 1，3-丁二醇 5.0 (7) 二丙二醇 3.0 ⑻二曱基聚矽氧(5mPa-s) 5.0 (9) 聚乙二醇 1500 1.0 (10) 單椰子油脂肪酸聚氧乙烯(20)山梨糖醇酐 3.0 (11) 單硬脂酸甘油醋 2.0 (12) 對羥苯甲酸乙酯 0.1 (13) 對羥苯甲酸丁酯 0.1 (14) 生育酚 0.1 (15) 成分(A)D-羥基脯胺酸 2.0 156750.doc -24- 201208711 (16)成分(B)N-曱基-β-丙胺酸 2.0 (17)香料 適量 (18)離子交換水 剩餘 <製法> 於（18)中添加（6)、（7)、（9)、（12)〜（16)並加熱至70°C而 製備。繼而，於7(TC下製備（1)〜（5)、 (8)、（10)、（11)、 (17)之油相。將其添加於先前之水相中 ，並以均質攪拌機 使乳化粒子均勻，進行脫氣、冷卻、過濾，獲得目標之潤 膚霜（0/W型）。 實施例12 :乳液 成分 調配量(質量°/〇) ⑴二曱基聚矽氧1.5mPa-s 3.0 (2)異十二烷 5.0 (3)角鯊烧 2.0 (4)烯烴寡聚物 1.0 (5)異壬酸異十三烷基酯 2.0 ⑹硬脂酸PEG-20 0.3 (7)倍半硬脂酸山梨糖醇酐 0.1 (8)單硬脂酸甘油酯（自己乳化型） 0.3 (9)香料 適量 (10)二丙二醇 1.0 (11)1,3-丁二醇 4.0 (12)甘油 2.0 (13)羧乙烯聚合物 0.1 156750.doc -25- 201208711 (14)烷基改性羧乙烯聚合物 0.05 (15)氫氧化鉀 適量 (16)成分(A)D-甲硫胺酸 0.5 (17)成分(Β)Ν-(4·-曱氧基苯曱醯基)-β-丙胺酸 3.5 (18)木賊萃取物 0.1 (19)金縷梅萃取物 0.1 (20)乙醇 5.0 (21)苯氧基乙醇 0.3 (22)離子交換水 剩餘 <製法> 使（10)〜（22)於70°C下均勻地溶解（水相）。繼而，使 (1)〜(9)於70°C下均勻地溶解，添加於先前之水相中，並以 分散機使其均勻地分散。進行脫氣、冷卻、過濾，獲得目 標之乳液。 實施例13 :潤膚霜（0/W型） 調配量(質量％) 0.1 0.5 4.0 5.0 2.0 5.0 3.0 0.1 成分 (1) 山窬醇 (2) 鯊肝醇 (3) 氫化聚異丁烯 (4) 液態石螺1 (5) 新戊酸異癸酯 (6) 十甲基環戊矽氧烷 (7) 異十六烷 ⑻香料 156750.doc -26- 201208711 (9) 聚乙二醇20000 l.o (10) 對羥苯甲酸乙酯 0.1 (11) 對羥苯曱酸丁酯 0.1 (12) 生育酚 〇.1 (13) (二曱基丙烯醯胺/丙烯醯基二曱基牛磺酸鈉)共 〇.4 聚物 (14) 成分(A)D-絲胺酸 2.5 (15) 成分(B)N-苯磺醯基-β-丙胺酸 0.1 (16) 山揸萃取物 0.1 (17) 蒲桃葉萃取物 0.1 (18) 地榆萃取物 0.1 (19) 丁香萃取物 0.1 (20) 魚腥草萃取物 0.1 (21) 蜀葵根萃取物 0.1 (22) 紫草根萃取物 0.1 (23) 1,3-丁二醇 3.0 (24) 甘油 3.0 (25) 離子交換水 剩餘 <製法> 於（25)中添加（9)〜(24)，並加熱至70°C加熱而製備。繼 而，於70°C下製備（1)〜(8)之油相。將其添加於水相中，並 以均質攪拌機使乳化粒子均勻。進行脫氣、冷卻、過濾， 獲得目標之潤膚霜（0/W型）。 實施例14 :潤膚霜（W/0型（Water in Oil，油中水型）） 156750.doc •27· 201208711 成分 調配量(質量。/〇) ⑴微晶蠟 2.0 (2)液態石蝶 20.0 (3)氫化菜籽種子油 5.0 (4)二油酸聚甘油-2 5.0 (5)對羥苯曱酸丁酯 0.1 ⑹香料 0.1 ⑺二曱基聚矽氧2mPa-s 10.0 (8)榖胺酸鈉 1.6 (9)成分(A)D-穀胺酸 0.5 (10)成分(A)D-天冬醯胺酸 1.0 (11)丙二醇 3.0 (12)成分(B)N-菸鹼醯基-β-丙胺酸 4.5 (13)洋甘菊萃取物 0.1 (14)苦參萃取物 0.1 (15)離子交換水 剩餘 <製法> 將一部分（15)及（8)、（9)及（10)及（4)加熱至50°C使其均勻 (胺基酸凝膠）。繼而，以分散機使先前之胺基酸凝膠均勻 地分散於使（1)〜（3)、（5)〜（7)之油相於70°C下溶解者中。進 而，於該分散液中一面充分地攪拌一面添加將剩餘之（15) 及（11)〜（14)加熱至70°C者，並以分散機使其均勻地乳化。 進行脫氣、冷卻、過濾，獲得目標之潤膚霜（W/0型）。 實施例15 :有抗老化·美白效杲之綜合霜（0/W型） 156750.doc -28 - 201208711 成分 調配量(質量％) (1)棕櫚酸 2.0 P)十六醇 1.5 (3)凡士林 3.0 (4)角鯊烧 5.0 (5)三乙基己醇 2.0 (6)油酸山梨糖醇酐 2.0 ⑺香料 0.1 (8)曱基三甲聚矽氧烷 10.0 (9)傳明酸 2.0 (10)(丙烯酸鈉/丙烯醯基二甲基鈉)共聚物 0.3 (商品名：SIMULGELEG，SEPIC公司製造） (11)對羥苯甲酸曱酯 0.1 (12)苯氧基乙醇 0.1 (13)成分(A)D-天冬醯胺酸 1.0 (14)成分(b)n-( r-哌啶)-丙酸 1.0 (15)兒茶萃取物 0.1 (16)草木犀萃取物 0.1 (17)離子交換水 剩餘 <製法> 於（17)中添加（9)〜（16)，加熱至70°C而製備。繼而，將 (1)〜（8)之油相加熱至70°C而製備。將該油相添加於先前製 備之水相中，利用均質攪拌機使乳化粒子均勻。進行脫 氣、冷卻、過濾，獲得目標之具有抗老化·美白效果之綜 156750.doc -29- 201208711 合霜（o/w型）。 實施例16 :潤膚霜（W/O型） 成分 調配量(質量％) (1)角鯊烧 3.0 (2)琥珀酸二乙基己酯 5.0 (3)異壬酸異壬酯 3.0 ⑷微晶蠟 1.0 (5)二硬脂基二曱基銨鋰蒙脫石 2.0 (6)PEG-10二曱聚矽氧烷 2.0 (7)十曱基環戊矽氧烷 10.0 (8)二甲基聚石夕氧6 mPa-s 2.0 ⑼香料 0.1 (10)1，3-丁二醇 5.0 (11)甘油 5.0 (12)成分(A)D-絲胺酸 2.0 (13)成分(Β)Ν-3·,4’,5|-三甲氧基-苯甲醯基-β-丙胺酸 1.0 (14)對羥苯甲酸乙酯 0.1 (15)苯氧基乙醇 0.2 (16)乙基維生素C 0.1 (17)野生百里香萃取物 0.1 (18)茶葉萃取物 0.1 (19)離子交換水 剩餘 <製法> 於70°C度下製備（1)〜(9)，使其均勻地分散·溶解獲得油性 156750.doc -30- 201208711 凝膠。於（19)中添加（10)〜（18)，使其均勻地溶解並製備成 70°C (水相）。將該水相向先前製備之油製凝膠中一面充分 地攪拌一面缓緩添加。以分散機均勻地製備乳化粒子。進 行脫氣、冷卻、過濾，獲得目標之潤膚霜（W/O型）。 實施例17 :凝膠狀美容液 成分 調配量(質量°/〇) (1)聚丙烯醯胺 2.0 (商品名：SEPIGEL305，SEPIC公司製造） (2)異十二烷 3.0 (3)二曱聚石夕氧炫2 mPa-s 0.5 (4)聚氧乙烯(20)山窬鍵 0.5 ⑶乙醇 5.0 (6)苯氧基乙醇 0.1 ⑺香料 0.1 (8)離子交換水 剩餘 (9)甘油 3.0 (10)1，3-丁二醇 3.0 (11)成分(A)D-羥基脯胺酸 0.5 (12)成分⑻N-環己基羰基-β-丙胺酸 0.5 (13)白蓮花萃取物 0.1 (14)生薑萃取物 0.1 (15)牡丹萃取物 0.1 (16)艾草萃取物 0.1 <製法> 156750.doc •31 - 201208711 於均勻地溶解有（1)、（5)〜（16)之水相中，添加（2)〜(4)之 混合物，並以分散機使其均勻地分散。進行脫氣、過濾， 獲得目標之凝膠狀美容液。 156750.doc 32·Comparative Example Ingredient name 6 7 8 9 10 (5) ΡΟΕ (21) octadecyl ether 2 2 2 2 2 (6) ΡΟΕ (2) stearyl ether 0.5 0.5 0.5 0.5 0.5 (7) Cetyl alcohol 2.5 2.5 2.5 2.5 2.5 (8) Liver alcohol 1 1 1 1 1 (9) Perfume 0.1 0.1 0.1 0.1 0.1 (10) Ion exchange water remaining remaining remaining remaining (11) 1,3-butanediol 4 4 4 4 4 (12 ) Ingredients (Β) 3-(Γ-piperidine)-propionic acid _ - • (13) Ingredients (Β)Ν-cyclohexyldecyl-β-alanine _ 2 4 5 _ (14) Ingredient (A)D -Alanine _ _ • _ (15) Ingredients (A) D-aspartic acid 0.1 _ _ (16) p-hydroxyphenyl phthalate 0.1 0.1 0.1 0.1 0.1 (17) Ethanol 3 3 3 3 3 (18 Phenoxyethanol 0.3 0.3 0.3 0.3 0.3 (19) (Vinyl 'pyrrolidone / propylene decyl fluorenyl taurate ammonium) copolymer 0.5 0.5 0.5 0.5 0.5 (20) citric acid 0.07 0.07 0.07 0.07 0.07 (21) Sodium citrate 0.03 0.03 0.03 0.03 0.03 <Confirmation test 1> Visual judgment value (average of 5 persons) 2 1.2 1.1 1.1 2 <Confirmation test 2> Human pore reduction effect (imprint determination value, average of 5 persons) ) 0.3 -0.4 -0.5 -0.7 0.2 <Confirmation test 3> Usability (sticky feeling when used) X Δ 〇Δ Δ <Confirmation test 4> Wrinkle improvement effect after 2 weeks of continuous use X 〇Δ XX <Confirmation test 5> Wrinkle improvement effect after 4 weeks of continuous use Δ Δ XXX <Confirmation test 6> After 2 weeks of use Sense of feeling of elasticity and skin feeling XXXXX <Confirmation test 7> The feeling of elasticity after 4 weeks of use and the feeling of use of the skin feeling elastic Δ Δ XXX It is clear from Tables 1 to 4 that the component which is an essential component of the present invention is contained ( A) One or more of D-amino acids, derivatives and/or salts thereof, and one or more of the components (Β) β-alanine derivatives and salts thereof, 156750. Doc -23-201208711 Example 1 to 1 ο, It is possible to provide a skin cosmetic which is excellent in use and has an effect of reducing pores and excellent in wrinkle and elasticity improvement effect, but lacks essential components (Α) and (Β) of the present invention or In Comparative Examples 1 to 10, the above-mentioned usability and the effect of reducing pores and the effect of improving wrinkles and elasticity were lacking. Hereinafter, other embodiments of the present invention will be exemplified. Further, the same effects as those described above were also carried out on the following examples, and as a result, excellent results were obtained. Example 11: Moisturizer (0/W type (Oil in Water)) Ingredients (% by mass) (1) Stearyl alcohol 2.0 (2) Behenyl alcohol 1.0 (3) Hydrogenated polyisobutylene 4.0 (4) Squalene burning 7.0 (5) Dipropylene glycol dipropanediol 2.0 (6) 1,3-butanediol 5.0 (7) Dipropylene glycol 3.0 (8) Dimercapto polyoxyl (5mPa-s) 5.0 (9) Polyethylene glycol 1500 1.0 (10) Single coconut oil fatty acid polyoxyethylene (20) sorbitan 3.0 (11) Monostearic acid glycerin 2.0 (12) Ethyl p-hydroxybenzoate 0.1 (13) p-Hydroxybenzene Butyl formate 0.1 (14) Tocopherol 0.1 (15) Ingredients (A) D-hydroxyproline 2.0 156750.doc -24- 201208711 (16) Ingredients (B) N-mercapto-β-alanine 2.0 (17 Perfume amount (18) ion-exchanged water remaining <Production Method> (6), (7), (9), (12) to (16) were added to (18) and heated to 70 ° C to prepare. Then, the oil phases of (1) to (5), (8), (10), (11), and (17) were prepared at 7 (TC), added to the previous aqueous phase, and made with a homomixer. The emulsified particles were uniform, degassed, cooled, and filtered to obtain the target moisturizer (0/W type). Example 12: Emulsion composition (mass °/〇) (1) Dimercapto-polyoxyl 1.5 mPa-s 3.0 (2) Isododecane 5.0 (3) Squalene 2.0 (4) Olefin oligomer 1.0 (5) Isotridecyl isononanoate 2.0 (6) Stearic acid PEG-20 0.3 (7) 1/2 Sorbitan stearate 0.1 (8) glyceryl monostearate (self-emulsified) 0.3 (9) Proper amount of (10) dipropylene glycol 1.0 (11) 1,3-butanediol 4.0 (12) glycerol 2.0 (13) Carboxyvinyl polymer 0.1 156750.doc -25- 201208711 (14) Alkyl modified carboxyvinyl polymer 0.05 (15) Potassium hydroxide amount (16) Ingredients (A) D-methionine 0.5 (17 ) Ingredients (Β)Ν-(4·-decyloxyphenyl)-β-alanine 3.5 (18) Equisetum extract 0.1 (19) Witch hazel extract 0.1 (20) Ethanol 5.0 (21) Benzene Oxyethanol 0.3 (22) ion exchange water remaining <preparation method > (10) to (22) at 7 The solution was uniformly dissolved (aqueous phase) at 0 ° C. Then, (1) to (9) were uniformly dissolved at 70 ° C, added to the previous aqueous phase, and uniformly dispersed by a disperser. Degassing, cooling, and filtration to obtain the target emulsion. Example 13: Moisturizer (0/W type) Formulation amount (% by mass) 0.1 0.5 4.0 5.0 2.0 5.0 3.0 0.1 Ingredients (1) Behenyl alcohol (2) Shark Hepatic alcohol (3) hydrogenated polyisobutylene (4) liquid stone snail 1 (5) isodecyl neopentanoate (6) decamethylcyclopentaoxane (7) isohexadecane (8) perfume 156750.doc -26- 201208711 (9) Polyethylene glycol 20000 lo (10) Ethyl p-hydroxybenzoate 0.1 (11) Butyl p-hydroxybenzoate 0.1 (12) Tocopherol 〇.1 (13) (Dimercapto acrylamide / Sodium propylene decyl sulfonium taurate) conjugate. 4 Polymer (14) Ingredient (A) D-serine 2.5 (15) Ingredient (B) N-Benzenesulfonyl-β-alanine 0.1 ( 16) Hawthorn Extract 0.1 (17) Rose Apple Leaf Extract 0.1 (18) Mantle Extract 0.1 (19) Clove Extract 0.1 (20) Houttuynia Extract 0.1 (21) Hollyhock Root Extract 0.1 (22) Lithospermum Root Extract 0.1 (23) 1,3-Butanediol 3.0 (24) Glycerin 3.0 (25) Ion exchange water left (manufacturing method) Adding (9) to (24) to (25), and heating to 70 ° C to prepare. Then, the oil phases of (1) to (8) were prepared at 70 °C. This was added to the aqueous phase, and the emulsified particles were homogenized by a homomixer. Degas, cool, and filter to obtain the target moisturizer (0/W type). Example 14: Moisturizer (W/0 type (Water in Oil)) 156750.doc •27· 201208711 Composition amount (mass./〇) (1) Microcrystalline wax 2.0 (2) Liquid stone butterfly 20.0 (3) Hydrogenated rapeseed seed oil 5.0 (4) Dioleic acid polyglycerol-2 5.0 (5) Butyl hydroxybenzoate 0.1 (6) Perfume 0.1 (7) Dimercaptopolyoxy 2mPa-s 10.0 (8) 榖Sodium amide 1.6 (9) Ingredients (A) D-glutamic acid 0.5 (10) Ingredients (A) D-aspartic acid 1.0 (11) Propylene glycol 3.0 (12) Ingredients (B) N-nicotine sulfhydryl -β-alanine 4.5 (13) Chamomile extract 0.1 (14) Sophora flavescens extract 0.1 (15) Ion exchange water remaining <Preparation method> Part (15) and (8), (9) and (10) And (4) heating to 50 ° C to make it uniform (amino acid gel). Then, the previous amino acid gel was uniformly dispersed in a dispersing machine to dissolve the oil phases of (1) to (3), (5) to (7) at 70 °C. Further, the remaining (15) and (11) to (14) were heated to 70 ° C while being sufficiently stirred in the dispersion, and uniformly emulsified by a disperser. Degas, cool, and filter to obtain the target moisturizer (W/0 type). Example 15: Comprehensive cream with anti-aging and whitening effect (0/W type) 156750.doc -28 - 201208711 Composition amount (% by mass) (1) Palmitic acid 2.0 P) Cetyl alcohol 1.5 (3) Vaseline 3.0 (4) squalane burning 5.0 (5) triethylhexanol 2.0 (6) oleic acid sorbitan 2.0 (7) perfume 0.1 (8) decyl trimethyl polyoxyl 10.0 (9) tranexamic acid 2.0 (10 (Sodium acrylate/propylene decyl dimethyl sodium) copolymer 0.3 (trade name: SIMULGELEG, manufactured by SEPIC) (11) oxime p-hydroxybenzoate 0.1 (12) phenoxyethanol 0.1 (13) component (A D-aspartic acid acetamino acid 1.0 (14) Ingredients (b) n-(r-piperidine)-propionic acid 1.0 (15) catechu extract 0.1 (16) Phyllostachys praecox extract 0.1 (17) ion-exchanged water The remaining <Production Process> was prepared by adding (9) to (16) to (17) and heating to 70 °C. Then, the oil phases of (1) to (8) were heated to 70 ° C to prepare. The oil phase was added to the previously prepared aqueous phase, and the emulsified particles were homogenized by a homomixer. Degassing, cooling, and filtration to obtain the target of anti-aging and whitening effect 156750.doc -29- 201208711 Combined frost (o/w type). Example 16: Moisturizer (W/O type) Ingredient amount (% by mass) (1) Squalat 3.0 (2) Diethylhexyl succinate 5.0 (3) Isodecyl isodecanoate 3.0 (4) Micro Crystal wax 1.0 (5) distearyl bis-decyl ammonium hectorite 2.0 (6) PEG-10 dioxane polyoxane 2.0 (7) decamethylcyclopentanoxane 10.0 (8) dimethyl Poly day oxygen 6 mPa-s 2.0 (9) Perfume 0.1 (10) 1,3-butanediol 5.0 (11) Glycerol 5.0 (12) Ingredients (A) D-serine 2.0 (13) Ingredients (Β)Ν- 3·,4',5|-Trimethoxy-benzimidyl-β-alanine 1.0 (14) Ethyl p-hydroxybenzoate 0.1 (15) Phenoxyethanol 0.2 (16) Ethyl vitamin C 0.1 ( 17) Wild thyme extract 0.1 (18) Tea extract 0.1 (19) Ion exchange water remaining <Preparation method> Prepare (1) to (9) at 70 ° C to uniformly disperse and dissolve to obtain oiliness 156750.doc -30- 201208711 Gel. (10) to (18) were added to (19) to be uniformly dissolved and prepared to 70 ° C (aqueous phase). The aqueous phase was gradually added while sufficiently stirring the previously prepared oil gel. The emulsified particles were uniformly prepared by a disperser. Degas, cool, and filter to obtain the target moisturizer (W/O type). Example 17: Formulation amount of gelatinous cosmetic liquid (mass °/〇) (1) Polyacrylamide 2.0 (trade name: SEPIGEL305, manufactured by SEPIC) (2) Isododecane 3.0 (3) Dimerization Shixi Oxygen 2 mPa-s 0.5 (4) Polyoxyethylene (20) Hawthorn Bond 0.5 (3) Ethanol 5.0 (6) Phenoxyethanol 0.1 (7) Perfume 0.1 (8) Ion-exchanged water remaining (9) Glycerol 3.0 (10 ) 1,3-butanediol 3.0 (11) component (A) D-hydroxyproline 0.5 (12) component (8) N-cyclohexylcarbonyl-β-alanine 0.5 (13) White lotus extract 0.1 (14) raw Ginger Extract 0.1 (15) Peony Extract 0.1 (16) Wormwood Extract 0.1 <Preparation Method> 156750.doc •31 - 201208711 The water phase of (1), (5)~(16) is uniformly dissolved Among them, a mixture of (2) to (4) was added and uniformly dispersed by a disperser. Degassing and filtration are carried out to obtain a gelatinous cosmetic liquid of the target. 156750.doc 32·