JPS597106A - Emulsifiable composition - Google Patents

Abstract

PURPOSE:To prepare an emulsifiable composition having fine particle size and high stability, and suitable for the use in the fields of food, cosmetic, pharmaceuticals, feed, etc., by emulsifying an oil-phase component in a water-soluble polyhydric alcohol and saponin or its salt. CONSTITUTION:The objective emulsifiable composition contains (A) an emulsifier comprising saponin which is a crude drug existing in nature and is known to have physiological and pharmacological effects such as expectrant, antitussive, antiphlogistic, central nervous system suppressing, and prophylactic effects, etc., and/or its salt, (B) a water-soluble polyhydric alcohol containing >=2 hydroxyl groups in the molecule (e.g. ethylene glycol), and (C) an oil-phase component such as beef tallow, squalane, olive oil, etc. The emulsifiable composition can be converted to a stable O/W-type emulsion composition containing uniformly dispersed fine particles by mixing with water.

Description

Detailed Description of the Invention The present invention is naturally occurring, expectorant, antitussive, anti-inflammatory, centrally suppressing, anti-fatigue, anti-ulcer, promoting cholesterol metabolism, promoting lipid metabolism, promoting synthesis of nucleic acids and proteins, and preventing infection. The aim is to use saponin, a herbal medicine known for its antitumor and other physiological and pharmacological effects, or its salts as emulsifiers in cosmetics, pharmaceuticals, and the like.

In recent years, much research has been conducted on emulsification, a large number of emulsifiers have been developed, and emulsification technology has made remarkable progress, and extremely stable emulsions are now widely used in all industries. However, in most of them, nonionic surfactants containing polyoxyethylene chains, anionic surfactants such as fatty soaps, cationic surfactants, and amphoteric surfactants are used as emulsifiers, and they are not safe for the human body. There are many things that are of concern.

On the other hand, in recent years there have been many attempts to use natural products, such as natural amphiphilic substances such as lecithin and saponin, and water-soluble polymers such as gums, as emulsifiers, which are considered to be highly safe. However, these natural substances have a lower interfacial tension lowering ability than the so-called U-surfactants J such as the above-mentioned nonionic surfactants, so their emulsifying power is relatively small, and it is difficult to use natural substances as emulsifiers. In the case of emulsion systems, emulsion particles generally have a rough emulsion particle diameter of approximately wμ and no emulsion with good stability over time was obtained.

Therefore, the present inventors conducted extensive research to develop a stable emulsion with uniform and fine particles using a natural substance with high human safety as an emulsifier.

Furthermore, they discovered that if this emulsion composition and water are mixed, a stable oil-in-water emulsion composition in which fine particles are uniformly dispersed can be obtained, leading to the completion of the present invention. .

(Hereinafter in the margin) That is, the present invention is characterized by containing one or more saponins or salts thereof, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component. The present invention provides an emulsified composition that contains the present invention, and an oil-in-water emulsified composition obtained by mixing the emulsified composition and water.

The emulsion composition obtained according to the present invention is a transparent or translucent viscous liquid or gel, and the oil-in-water emulsion composition with water added is an emulsion of milky white fine particles. These fine particle emulsions have particle sizes so small that they cannot be achieved using the conventional emulsification method of dissolving natural substances in water and then emulsifying and mixing the oil phase components. The reason is thought to be that saponin or its salt and protein quickly align and interact at the polyhydric alcohol-oil phase component interface, which has a lower interfacial tension than the water-oil phase component interface. The water-soluble polyhydric alcohol used in this is a water-soluble polyhydric alcohol containing two or more hydroxyl groups in the molecule, such as ethylene glycol, propylene glycol, 1.3-butylene glycol, 1.4-7' tylene, etc. Glycol, dipropylene glycol, glycerin, and polyglycerin such as diglycerin, triglycerin, and tetraglycerin, glucose, maltose, malditol, sucrose, fructose,
These include xylitol, sorbitol, maltotriose, threitol, erythritol, starch-degrading sugar, and starch-degrading sugar-reduced alcohol. Among these, one or two groups are selected and used. The blending amount is 2 to 95 nails, 1ff1% (hereinafter simply referred to as %) of the emulsified composition.
is preferred).

The saponins used in the present invention are extracts obtained from plants and animals.

Saponins essentially consist of zabogenin and sugars.

Zubogenin is steroid-based or triterpene-based, and the sugar may be any of monosaccharides, trisaccharides, and oligosaccharides whose constituent sugars include glucose, xylose gluconate, rhamnose, arabinose, vanazatri, and t-ru.

The plants and animals from which saponins are extracted are shown below.

Senega onji, Bellflower, Goshitsu, Saikochikusetsu Carrot, Carrot, Bakumodo, Mokutsuku, Salsa,
Soaking, digestion, decoction, infusion, or pressing of asparagus, yucca, ruscus, discorea, higan flower, Killayaa Bonaria, guaiacum, licorice, dianthus, icus, sapindus, sabonaria, etc. obtained by.

Some saponins form salts while others do not. When used as salts, the following substances are used as salt-forming substances. Inorganic bases such as lithium hydroxide, sodium hydroxide/potassium hydroxide, cesium hydroxide, ammonium hydroxide, basic amino acids such as arginine, ligno, histidine, ornithine, and basic oligopeptide monomers containing these as residues. The salt is a base such as a basic amine such as ethanolamine, jetanolamine, or triethanolamine, and the salt may be produced not only in advance but also during the production process of the emulsified composition. The state of the salt aqueous solution can be suitably used in a wide range of 2 to 11.

The amounts of saponin or its salt and the polyhydric alcohol having two or more hydroxyl groups in the molecule are in the ratio of 1:1 to 1.
A range of 000 is preferred. If the ratio of saponin or its salt is more than 1 part to 1 part of polyhydric alcohol, it will be difficult to dissolve saponin, and if it is less than 1/1.000, emulsion stability will deteriorate.

The oil phase components used in the present invention include beef tallow, squalane, animal and vegetable oils such as olive oil and rice bran oil, and hydrocarbons, liquid paraffin, and the mineral MI+ of petrolatum.
, isopropyl myristate, pentaerythritol
Oils and oil-soluble oils commonly used in the cosmetics, pharmaceutical, and food industries, such as ester oils such as tetra-2-ethyl hegisanate, vitamin A palmitate, and vitamin E acetate, and silicone oils such as methylphenyl silicone and dimethyl silicone. It is desirable to be able to list drugs.

In addition to the above-mentioned essential components, the emulsified composition according to the present invention includes a nonionic surfactant, an anionic surfactant, a cationic surfactant, an amphoteric surfactant, and a drug. , ultraviolet absorbers, preservatives, antioxidants, etc. may be mixed and added. Furthermore, alcohol, fatty acids, other water-soluble polymers, etc. may be added for the purpose of homogeneity stabilization and viscosity adjustment.

An emulsified composition can be obtained by dissolving saponin or its salt in a polyhydric alcohol and gradually adding the oil phase components while stirring. In this case, it is preferable to perform a homomixer treatment, but a good emulsified composition can be obtained even with a weak stirring force such as manual stirring.

The emulsified composition obtained here is a homogeneous transparent or translucent gel or viscous liquid, so it can be used as it is.
For example, it can be used as sun care jelly, serum, edible jelly, medicated jelly, pine surge jelly, lubricating oil, etc.
It can be suitably used in all fields such as cosmetics, medicine, and feed.

Next, an emulsified composition containing one or more of the saponins or their salts and two or more hydroxyl groups in the molecule is obtained. In this case, it is preferable to perform homomixer treatment.

(Left below) Regarding the quantitative relationship between the emulsifying composition and water, it is possible to produce an emulsion in an extremely wide range of proportions, but generally the emulsifying composition is 5 to 80 parts water, 95 to 20 parts. Department.

The above water may contain moisturizing agents, water-soluble vitamins, water-soluble preservatives, water-soluble drugs, water-soluble polymers, etc. as necessary for cosmetics,
It can dissolve aqueous phase components commonly used in the pharmaceutical, food, and other industries.

The oil-in-water emulsion composition obtained here is a milky white viscous or low viscosity liquid in which uniform fine particles are dispersed, so it can be used in its original form as well as having homogeneity stabilization, viscosity adjustment, or medicinal effects. In addition, other water-soluble polymers, drugs, surfactants, etc. can be added to make emulsions,
It can be suitably used in all fields such as cosmetics such as creams and foundations, toilet products such as shampoos and soaps, pharmaceuticals such as urea cream and oilseed cream, and foods such as mayonnaise.

Hereinafter, the present invention will be explained in more detail with reference to Examples and Comparative Examples. The present invention is not limited to this.

Examples 1 to 9, Comparative Examples 1 to 3, saponin, polyhydric alcohol, and oil phase components were blended in the composition and amount shown in Table 1, and treated with a homomixer at 70 ° C. to make an emulsified composition. . Further, 10 times the amount of water was added to this emulsified composition while stirring at room temperature to prepare an oil-in-water emulsified composition. Observe the state of the emulsified composition and oil-in-water emulsified composition, measure and evaluate the characteristic values,
The results are shown in Table-1. Note that the numbers for each component are weight %.

Good emulsification was not observed in Comparative Example 1.3, which does not contain polyhydric alcohol, and Comparative Example 2, which is a conventional emulsification method in which polyhydric alcohol is dissolved in a large amount of water and oil is emulsified therein. On the other hand, in Examples 1 to 9 according to the present invention, very good transparent or translucent viscous liquids or gels were obtained at all levels, and furthermore, the The oil emulsion composition was a stable emulsion with very fine oil droplets dispersed therein.

(The following is a blank space) ■ The condition of the oil-in-water emulsion composition in Table 1 was judged based on the following criteria after being left for one day.

◎ Emulsion particle size 1 μ or less 0 1-5 μ △ 5-10 μX
10 μ or more (blank below) Example 10 Beauty jelly (% by weight) (Δ) Carrot saponin 2
0Ruscus extract f-
0 Glycerin (pharmacopoeia) 45
．． 0 Fundroitin sulfate sodium 0
．． 2 Adenosine triphosphate 0.
2(B) Jojoba oil
20.0 Pentaerythritol Tetra 2 Ethyl Hexanate 2α6 Vaseline
&0 vitamin A balmite)
LOα-tocopherol
1.0 Preservative 0.5 Flavoring
0.5 Phase (A) was sufficiently stirred at 70°C, and (B) dissolved at 70°C was added to phase (A) while stirring. This was treated with a homomixer, stirred and cooled to obtain beauty jelly.This beauty jelly is a viscous, creamy, electrically conductive gel.
It was an emulsion composition that was highly safe and had excellent stability over time, and when applied to the skin, it spread very well and had the property of being used over a wide range with a small amount.Example 11 Emollient emulsion (wt%) ) (A) Diglycerin 10.
0 Multitol 75% aqueous solution 10.01
．． 3 Butylene glycol 5.0 Ginseng extract 3.0 Onji extract LO vitamin B6 hydrochloride 0.2 Allantoin 0.2 Calcium hydroxide 0.06 (E) Olive oil
lα0 (2-octyl)
dodecyl palmitate 5.0 vaseline
&0 ethinyl estradiol
α1 Preservative α4 Flavoring 0
3 (0) Purified water 5L44 carboxyvinyl polymer 02 Sodium hyaluronate α1 According to the manufacturing method of Example 10, an emulsion composition was obtained from (A) and (E), and the temperature was adjusted to 70°C, and the temperature was adjusted separately and kept at 70°C. Oi・ta thickener aqueous solution U
After diluting and dispersing, the mixture is cooled to obtain an emollient oil-in-water emulsion. The viscosity of this emulsion was 5180 cp8 at 3:1''C, and the emulsion had a stable emulsion particle size of about 1 to 3 μm and a familiar texture, and was also expected to have the medicinal effects of saponin.

Example pine surge cream (% by weight) (A) Sorbitol 70% aqueous solution 22
．． 0 glucose 5,
0 Purified Saponin 5.0 (
B) Liquid paraffin 450 glyceryl tristearate 5.
0 Glyceryl triolate 5.0
Preservative α5 Flavor 0
．． 3(0) Purified water 110 Sodium alginate α2 According to the manufacturing method of Example 11, Pine 1-diku IJ-me was obtained. This pine surge cream is a highly stable oil-in-water emulsion composition with a hardness of 8 at 25°C, a slightly transparent feeling, and an emulsion particle size of Q, 5 to 3μ, and when the skin is pine surged. It had a feeling of use with little change in spread depending on the number of pine surges.

patent applicant Shiseido Co., Ltd.

Claims (2)

[Claims] (1) An emulsified composition containing one or more saponins or salts thereof, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, and an oil phase component◇ (2) An emulsified composition containing one or more saponins or salts thereof, a water-soluble polyhydric alcohol having two or more hydroxyl groups in the molecule, an oil phase composition, and water. Characteristic oil-in-water emulsion composition.