CN111643376B - Nanoemulsion composition and application thereof - Google Patents
Nanoemulsion composition and application thereof Download PDFInfo
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- CN111643376B CN111643376B CN202010540527.9A CN202010540527A CN111643376B CN 111643376 B CN111643376 B CN 111643376B CN 202010540527 A CN202010540527 A CN 202010540527A CN 111643376 B CN111643376 B CN 111643376B
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- alcohol
- oil
- nanoemulsion composition
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- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 38
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 37
- 239000013543 active substance Substances 0.000 claims abstract description 30
- 239000004519 grease Substances 0.000 claims abstract description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 150000004676 glycans Chemical class 0.000 claims abstract description 10
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 10
- 239000005017 polysaccharide Substances 0.000 claims abstract description 10
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 5
- -1 alkyl glycoside Chemical class 0.000 claims description 15
- 239000002537 cosmetic Substances 0.000 claims description 12
- 239000004094 surface-active agent Substances 0.000 claims description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 239000000839 emulsion Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000007921 spray Substances 0.000 claims description 8
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 7
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 229930182470 glycoside Natural products 0.000 claims description 6
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- 238000004945 emulsification Methods 0.000 claims description 5
- 230000002209 hydrophobic effect Effects 0.000 claims description 5
- 238000006116 polymerization reaction Methods 0.000 claims description 5
- KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 claims description 5
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- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical class CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 claims description 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 claims description 4
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- 150000001413 amino acids Chemical class 0.000 claims description 4
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- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 claims description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 4
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
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- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- XGFDHKJUZCCPKQ-UHFFFAOYSA-N nonadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCO XGFDHKJUZCCPKQ-UHFFFAOYSA-N 0.000 claims description 4
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- REIUXOLGHVXAEO-UHFFFAOYSA-N pentadecan-1-ol Chemical compound CCCCCCCCCCCCCCCO REIUXOLGHVXAEO-UHFFFAOYSA-N 0.000 claims description 4
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- 210000004761 scalp Anatomy 0.000 claims description 4
- 229920002545 silicone oil Polymers 0.000 claims description 4
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 4
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
- 229960000541 cetyl alcohol Drugs 0.000 claims description 3
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- LBQIJVLKGVZRIW-ZDUSSCGKSA-N glabridin Chemical compound C1([C@H]2CC3=CC=C4OC(C=CC4=C3OC2)(C)C)=CC=C(O)C=C1O LBQIJVLKGVZRIW-ZDUSSCGKSA-N 0.000 claims description 3
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- LBQIJVLKGVZRIW-UHFFFAOYSA-N glabridine Natural products C1OC2=C3C=CC(C)(C)OC3=CC=C2CC1C1=CC=C(O)C=C1O LBQIJVLKGVZRIW-UHFFFAOYSA-N 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
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- 229940057402 undecyl alcohol Drugs 0.000 claims description 3
- URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 claims description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 2
- JXNPEDYJTDQORS-HZJYTTRNSA-N (9Z,12Z)-octadecadien-1-ol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCO JXNPEDYJTDQORS-HZJYTTRNSA-N 0.000 claims description 2
- XFRVVPUIAFSTFO-UHFFFAOYSA-N 1-Tridecanol Chemical compound CCCCCCCCCCCCCO XFRVVPUIAFSTFO-UHFFFAOYSA-N 0.000 claims description 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 2
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Abstract
The invention discloses a nanoemulsion composition and application thereof, and the nanoemulsion composition comprises the following components: 0.005-2.5% of emulsifier; (B) higher alcohols 0.01-5%; (C) 0.02-60% of grease; (D) oil-soluble active 0.01-15%; (E) 3-30% of a polyol or polysaccharide; wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B). The invention prepares the nano emulsion composition with average grain diameter less than or equal to 200nm by selecting low-content and specific type of emulsifying agent, compounding with specific content of higher alcohol, grease, oil-soluble active substance and polyalcohol or polysaccharide, controlling the sum of the compounding weight of the emulsifying agent and the emulsifying agent, and the nano emulsion composition can obviously reduce the irritation caused by the emulsifying agent; the stability and transdermal absorption effect of the oil-soluble active substances are improved, and the irritation effect is reduced, so that the utilization rate, the efficacy and the skin tolerance of the efficacy components are improved.
Description
Technical Field
The invention relates to the technical field of cosmetics, foods or medicines, in particular to a nanoemulsion composition with the functions of improving the stability and efficacy of oil-soluble active ingredients and reducing irritation and application thereof.
Background
Various emulsifying compositions added with functional active substances are widely applied to the fields of cosmetics, foods or medicines, but most of the emulsifying compositions are cream-like or white-turbid emulsion traditional O/W emulsifying systems, have no effect of improving the stability of the functional active substances, are easy to change color and smell, are easy to generate stability layering under severe conditions, such as oil-soluble active substances such as tetraisopalmitate ascorbate, retinol palmitate, resveratrol and the like, are easy to generate high-temperature color change decomposition, and can influence the appearance of the products and lead to the reduction of the content of the active substances; because of the larger particle size, the composition has no effect of promoting transdermal absorption; and because part of the effective active substances have certain irritation, the traditional O/W emulsion system mainly relies on reducing the dosage of the effective active substances or adding a relieving component to reduce the irritation, for example, oil-soluble active substances such as glabridin are easy to cause skin irritation due to higher irritation. These characteristics limit their use in cosmetics, foods or pharmaceuticals for skin, scalp and hair, etc.
Compared with the traditional O/W emulsion system, the nano emulsion is more suitable for the transmission of the efficacy active substances, is more beneficial to the transmission and transdermal absorption of the internal phase efficacy active substances due to the small droplet size and large surface area, and can reduce the use of permeation enhancers and eliminate potential irritation. Because of its slow release effect, it can reduce the irritation of the functional active.
However, at present, the nanoemulsion mainly adopts a D-phase emulsification, an agglutination method or PIT emulsification, and has certain requirements on the emulsifier selection of the formula, the dosage of the emulsifier, the type and content of grease and the process; the emulsifier content increases, potentially leading to increased irritation of the formulation; and the oil content cannot be too high due to stability, so that the oil-soluble active ingredients cannot be fully dissolved, and the stability of the oil-soluble active ingredients is easy to cause problems; the types of oils and fats are limited, and the dissolution of oil-soluble active ingredients cannot be satisfied. These characteristics limit their use in cosmetics, foods or pharmaceuticals for skin, scalp and hair, etc.
Disclosure of Invention
In view of the above, the present invention aims to overcome the disadvantages of the prior art, and provide a nanoemulsion composition (average particle diameter of 200nm or less) having improved stability and efficacy of oil-soluble active ingredients and reduced irritation, which has low viscosity, thereby having a convenient feeling in use; the dosage of the emulsifying agent can be reduced to 1/214 of the dosage of the grease, so that the irritation caused by the emulsifying agent can be obviously reduced, and the tolerance of the skin is improved; aiming at the characteristics that the traditional emulsifying system formula needs to consider that different types of grease need to be emulsified with different HLB values, the invention can directly use different types of grease without changing the types of the emulsifying agents and the dosage thereof in the formula, and the characteristics can be dissolved by using different types of grease aiming at different oil-soluble active substances, thus greatly widening the adaptability of the formula to the oil-soluble active substances and providing excellent formula stability, thereby simplifying the formula development; the stability of the oil-soluble active substance can be improved, the transdermal absorption effect of the oil-soluble active substance can be improved, and the irritation effect of the oil-soluble active substance can be reduced through the slow release effect, so that the utilization rate of the effective components and the product effect can be improved.
The nanoemulsion composition provided by the invention comprises the following components in percentage by weight:
wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B).
Preferably, the nanoemulsion composition comprises the following components in percentage by weight:
wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B).
More preferably, the nanoemulsion composition comprises the following components in percentage by weight:
wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B).
Wherein the component (A) is selected from one or more of alkyl glycoside emulsifier, polyglycerol emulsifier, amino acid gemini surfactant, lecithin and modified emulsifier thereof.
The alkyl glycoside emulsifiers of component (A) according to the invention, the alkyl groups of which may be used, are saturated and unsaturated alkyl groups of 8 to 22 carbon atoms. They may be used alone or in combination of two or more of the foregoing. One or more of lauryl, cocoyl, myristyl, cetyl and stearyl are particularly preferred in view of the source of the raw materials.
The degree of polymerization of glucose of the alkyl glycoside of the component (A) is not particularly limited, and the average degree of polymerization of glycoside is particularly preferably 1 to 5 in view of the source of the raw material.
The polyglycerol emulsifier of component (A) of the present invention may have alkyl groups of 8 to 22 carbon atoms, both saturated and unsaturated. They may be used alone or in combination of two or more of the foregoing. One or more of lauryl, cocoyl, myristyl, cetyl and stearyl are particularly preferred in view of the source of the raw materials.
The polyglycerin emulsifier of component (A) has a polymerization degree of glycerin selected to have a polymerization degree of 6 to 10 in consideration of the source of raw materials.
The amino acid gemini surfactant of the component (A) at least comprises two hydrophobic hydrocarbon chains, two polar head groups and a connecting group, and is specifically selected from one or more of arginine-based gemini surfactant, lysine-based gemini surfactant, cystine-based gemini surfactant and serine-based gemini surfactant; more preferably sodium di (lauramide glutamine) lysine.
The lecithin and the modified emulsifier of the component (A) are selected from one or more of soybean lecithin, hydroxylated lecithin, hydrogenated lysolecithin and lysolecithin.
Wherein the sum of the contents of the component (A) +the component (B) is more than or equal to 0.015 percent, and the partial volatilization of moisture is carried out during the application, so that the cream-like use feeling can be obtained under the dosage; the sum of the contents of component (A) +component (B) is preferably not less than 0.1%; when the sum of the contents of the component (A) +the component (B) is less than 0.015%, gelation is not caused, and a frosty use feeling is not provided.
Preferably, the component (a): the compound weight ratio of the component (B) is more than or equal to 1:0.3, preferably 1:0.6. component (A): component (B) < 1: at 0.3, the viscosity increases during the stability of the formulation, failing to meet the low viscosity requirements required by the present invention.
The higher alcohol of the component (B) can comprise one or more of octanol, decanol, lauryl alcohol, myristyl alcohol, stearyl alcohol, isostearyl alcohol, cetyl alcohol, oleyl alcohol, linoleyl alcohol, behenyl alcohol, octanol, undecyl alcohol, tridecyl alcohol, pentadecyl alcohol, heptadecyl alcohol, nonadecyl alcohol and hendecyl alcohol. These may be used alone or in combination of two or more of the foregoing, with stearyl alcohol and cetyl alcohol being particularly preferred.
The component (C) is one or more selected from silicone oil, silica gel and modified matters thereof, fat, oil, wax, hydrophobic plant extract, olefin, lipoid, ester, liquid alcohol, vitamin, sun-screening agent, essential oil and phosphate. Silicone oils, silicone gels and modifications thereof, such as linear or cyclic polydimethylsiloxanes, amino groups, alkyl groups, phenyl silicone oils, and the like; the fats and oils include natural fats and oils such as shea butter, jojoba seed oil, avocado oil, rice bran oil, olive oil, grape seed oil, sunflower seed oil, soybean oil, almond oil, coconut oil, beef tallow, lard, etc.; saturated oil obtained by hydrogenating the above oil; and synthetic mono-, di-or triglycerides; wherein, waxes, such as lanolin and the like and corresponding derivatives thereof; the hydrophobic plant extract specifically refers to an oil-soluble plant extract; such as liquid paraffin, mineral esters, squalene, squalane, mineral oil, and the like; such lipids as cholesterol, sucrose esters, and the like; such esters as isopropyl myristate, isopropyl palmitate, and the like; such as octyldodecanol and the like; the essential oil is selected from peppermint oil, jasmine oil, lemon oil, eucalyptus oil, tea tree oil, lavender essential oil, etc.; they may be used alone or in combination of two or more of the foregoing.
The component (D) is selected from phytosterol, resveratrol, ceramide-like, coenzyme Q10, kojic dipalmitate, fullerene, glabridin and oil-soluble vitamins and derivatives thereof. The oil-soluble vitamins and their derivatives, such as vitamins A, D and E, and vitamin alkyl esters, including vitamin C alkyl esters.
The component (E) is one or more selected from glycerol, sorbitol, propylene glycol, butanediol, pentanediol, isopentyl glycol, hexanediol, glucose, maltose, maltitol, sucrose, fructose, xylitol, pentaerythritol and starch degrading sugar.
Wherein, the average grain diameter of the nano emulsion composition is less than or equal to 200nm, and the use process can be one or more of high-pressure homogenization, micro-jet flow or ultrasonic wave in high-energy emulsification. If the average particle diameter exceeds 200nm, demulsification or viscosity increase may occur at low viscosity. The average particle diameter used herein is measured by a dynamic scattering method, specifically, particle diameter measurement is performed using a malvern mastersizer 3000.
The nanoemulsion composition of the present invention has improved stability and efficacy of oil-soluble active ingredients and reduced irritation, and may suitably contain various suitable components for use in general cosmetics, special cosmetics, foods or medicines, etc., in addition to the above-mentioned main ingredients, without reducing the effects of the present invention. More specifically, water, essence, ultraviolet absorber, wetting agent, physiologically active ingredient, antioxidant, anti-inflammatory agent, antibacterial agent, antiperspirant, chelating agent (such as disodium EDTA), thickener, neutralizing agent, pH adjustor (such as citric acid) and the like may be included, and the above components may be contained according to specific uses and forms, with their addition amounts being conventional addition amounts in cosmetics, foods or medicines.
After the thickening agent such as carbomer is added, the moisturizing effect of the cream emulsion is achieved, the effect of wiping water is achieved, and the cream emulsion has good use feeling which cannot be achieved by the conventional cream emulsion formula.
The nanoemulsion composition provided by the invention has the advantages of improving the stability and efficacy of oil-soluble active ingredients and reducing irritation, and is suitable for being applied to cosmetics, foods or medicines for skin, scalp and hair.
Compared with the prior art, the invention has the following beneficial effects:
the invention prepares the nano emulsion composition with average grain diameter less than or equal to 200nm by selecting low-content and specific-type emulsifying agent, compounding the low-content emulsifying agent, grease, oil-soluble active substance and polyalcohol or polysaccharide with specific content, controlling the content of the grease to be more than or equal to the sum of the compound weights of the emulsifying agent and the emulsifying agent, and the nano emulsion composition has low viscosity, thereby having convenient use feeling; the dosage of the emulsifying agent can be reduced to 1/214 of the dosage of the grease, so that the irritation caused by the emulsifying agent can be obviously reduced, and the tolerance of the skin is improved; aiming at the characteristics that the traditional emulsifying system formula needs to consider that different types of grease need to be emulsified with different HLB values, the invention can directly use different types of grease without changing the types of the emulsifying agents and the dosage thereof in the formula, and the characteristics can be dissolved by using different types of grease aiming at different oil-soluble active substances, thus greatly widening the adaptability of the formula to the oil-soluble active substances and providing excellent formula stability, thereby simplifying the formula development; the stability of the oil-soluble active substance can be improved, the transdermal absorption effect of the oil-soluble active substance can be improved, and the irritation effect of the oil-soluble active substance can be reduced through the slow release effect, so that the utilization rate of the effective components and the product effect can be improved.
Detailed Description
The present invention will be further described by the following specific embodiments, which are preferred embodiments of the present invention, but the embodiments of the present invention are not limited by the following examples.
The raw materials used in the examples of the present invention are all commercially available.
The test method of each performance index is as follows:
stability test method of nanoemulsion composition: samples were placed in an oven at room temperature and 50 ℃ for 4 weeks, respectively, and tested for appearance, particle size, viscosity, and oil-soluble active stability.
Method for testing the appearance of nanoemulsion compositions: visual observation was performed at room temperature and in the absence of direct sunlight.
Method for testing average particle size of nanoemulsion composition: particle size measurements were made using a malvern mastersizer3000, using D50 as the particle size measurement.
Method for testing the viscosity of nanoemulsion compositions:
viscosity in the range of 0-50 mPa.s: brookfiled DV-C digital display viscometer, no. 61 rotor, rotation speed 60rpm, stock body temperature: 25 ℃, reading time: readings were taken 1 minute after start-up.
Viscosity in the range of 51-300 mPa.s: brookfiled DV-C digital display viscometer, no. 62 rotor, rotation speed 60rpm, stock body temperature: 25 ℃, reading time: readings were taken 1 minute after start-up.
Viscosity range 301-1200 mpa.s: brookfiled DV-C digital display viscometer, no. 63 rotor, rotation speed 60rpm, stock body temperature: 25 ℃, reading time: readings were taken 1 minute after start-up.
Viscosity ranges of 1200-6000 mPa.s: brookfiled DV-C digital display viscometer, no. 64 rotor, rotation speed 60rpm, stock body temperature: 25 ℃, reading time: readings were taken 1 minute after start-up.
Test method for stability of oil-soluble active substance: and calibrating the content of the oil-soluble active substances by adopting a liquid chromatography method and the like, and comparing a sample with the stability at 50 ℃ for 1 month with the initial sample test result to obtain the retention rate. Examples 1 to 33 and comparative examples 1 to 12:
heating the component (A) emulsifier, the component (B) higher alcohol, the component (C) grease and the component (D) oil-soluble active substance to a specified temperature according to the proportion, and stirring and dissolving uniformly to obtain oil phase premixing; heating water and the polyol or polysaccharide of the component (E) to a specified temperature, and stirring and dissolving uniformly to obtain water phase premixing; premixing the oil phase, adding the oil phase into the water phase for premixing, preserving heat and stirring uniformly, and homogenizing under high pressure until the average particle size of the material is less than or equal to 200nm (the particle size is homogenized to about 250nm and 350nm in the comparative example); cooling, adding the rest components, and adjusting pH to a specified range to obtain the nanoemulsion composition. Specific data of performance indexes such as appearance, average particle diameter, viscosity, use feeling, stability of oil-soluble active substances and the like of the prepared nano emulsion composition are shown in tables 1-6.
Table 1 comparative examples and comparative examples of the content and types of the emulsifier (A) in weight percentage
Wherein the viscosity of the 50 ℃ stability sample in examples 2 and 3 is increased to 25.5-47.3, which affects the pumping efficiency of the spray pump head, and the stability sample in comparative example 1 is layered, and the color deepening, particle size and viscosity increase of the 50 ℃ stability sample in comparative example 2 are obvious. It is stated that varying amounts of emulsifier lead to oxidation of the active during stability of the sample, and to increased particle size and viscosity.
Table 2 examples and comparative examples (weight percent) of the content and kind of the higher alcohol of the comparative component (B)
Wherein the viscosity of the 50 ℃ stability samples in examples 10, 11 and 13 increased to 37.9-89.4, which affects the pumping efficiency of the spray pump head, and the pump head has higher selectivity, the color of the 50 ℃ stability samples in comparative examples 3, 4 and 5 deepened, and the particle size and viscosity increased significantly. It is shown that varying amounts of higher alcohols lead to oxidation of the active during stability of the sample, and to increased particle size and viscosity.
Table 3 examples and comparative examples (weight percentage) of the content and type of the oil and fat of the comparative component (C)
Wherein the viscosity of the 50 ℃ stability samples in examples 16 and 17 is increased to 29.7-41.6, the efficiency of pumping out of the spray pump head is affected, the pump head is more selective, the color of the 50 ℃ stability samples in comparative example 6 is deepened, the particle size and the viscosity are obviously increased, and the 50 ℃ stability of comparative example 7 is demulsified and layered. It is shown that varying amounts of grease lead to oxidation of the active during stability of the sample, and increases in particle size and viscosity.
Table 4 comparative examples and comparative examples (weight percent) of the content and type of oil-soluble active of component (D)
The viscosity of the samples in examples 25 and 26, which were stable at 50 c, increased to 27.9-34.2, affected the efficiency of the spray pump head, had higher selectivity to the pump head, and had a darker color, affecting the range of application. The comparative example 8 has no active substances and no specific efficacy, can not meet the requirements of consumers on the efficacy, and can only be used as a basic cosmetic; the comparative example 9 was demulsified and layered with 50℃stability, and after uniform stirring, the oil-soluble active retention rate was lower than that of examples 23 to 30. It is shown that varying amounts of oil soluble actives can lead to reduced oxidation and content of actives, increased particle size and viscosity during sample stability, and even to demulsification delamination.
Table 5 examples and comparative examples (weight percent) of the content and types of the polyol or polysaccharide (E) as the comparative component
Wherein the viscosity of the samples in examples 32 and 33 with 50 ℃ stability is increased to 29.8-47.3, which affects the pumping efficiency of the spray pump head and has higher selectivity to the pump head; the color of the 50 ℃ stable sample in comparative example 10 deepens, and the particle size and viscosity increase are obvious; although the sample of comparative example 11 had good stability at 50℃, the initial viscosity was high due to excessive polyol, which affected the spray pump and resulted in a sticky skin feel. It is stated that varying amounts of polyol or polysaccharide lead to oxidation of the active, increased particle size and viscosity during sample stability, and that increasing amounts of polyol or polysaccharide lead to higher initial viscosity of the formulation and a sticky skin feel, so excessive amounts are not recommended.
Table 6 compares the different emulsion particle sizes
In comparative example 14, stable samples at a temperature of 50 ℃ are evenly layered, and a stable formula cannot be formed, so that the formula needs to be homogenized under high pressure, and micro-jet or ultrasonic waves are required to ensure that the particle size of the samples is less than or equal to 200nm. The room temperature viscosity was higher in comparative example 12 (particle size over 200nm, 264 nm) and comparative example 11 (particle size over 200nm, 347 nm) than in example 38, and the color deepening, particle size and viscosity increase of the 50℃stable sample were evident, resulting in difficulty in pumping out by spraying. The specification that the different particle sizes and no high-energy emulsification are carried out, so that the particle size is less than or equal to 200nm, the normal-temperature viscosity of the sample is higher, and the sample is not easy to pump through a spray pump; active oxidation, particle size and viscosity increase during high temperature stability, making pumping out by spraying more difficult.
Application formulation example 1: the nanoemulsion composition described in example 1 was mixed with other cosmetic, food or pharmaceutical raw materials to prepare gel, and the specific formulation is shown in table 7:
TABLE 7
Application formulation example 2: the nanoemulsion composition described in example 17 was mixed with other cosmetic, food or pharmaceutical raw materials to prepare an emulsion, and the specific formulation is shown in table 8:
TABLE 8
Claims (10)
1. The nanoemulsion composition is characterized by comprising the following components in percentage by weight:
(A) 0.14-2.5% of emulsifying agent;
(B) 0.26-5% of higher alcohol;
(C) 15-60% of grease;
(D) 0.01-15% of oil-soluble active substance;
(E) 3-30% of polyalcohol or polysaccharide;
wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B);
the average grain diameter of the nano emulsion composition is less than or equal to 200nm;
the component (A) is one or more selected from alkyl glycoside emulsifier, polyglycerol emulsifier, amino acid gemini surfactant, lecithin and modified emulsifier thereof;
the component (A): the compound weight ratio of the component (B) is more than or equal to 1:0.3.
2. the nanoemulsion composition according to claim 1, characterized in that it comprises the following components in weight percent:
(A) 0.14-1.5% of emulsifying agent;
(B) 0.26-3% of higher alcohol;
(C) 15-40% of grease;
(D) 0.01-10% of oil-soluble active substance;
(E) 6-25% of polyalcohol or polysaccharide;
wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B).
3. The nanoemulsion composition according to claim 2, characterized in that it comprises the following components in weight percent:
(A) 0.14-1.2% of emulsifying agent;
(B) 0.26-2% of higher alcohol;
(C) 15-20% of grease;
(D) 0.01-5% of oil-soluble active substance;
(E) 10-20% of polyalcohol or polysaccharide;
wherein the content of the component (C) is more than or equal to the sum of the contents of the component (A) +the component (B).
4. The nanoemulsion composition according to claim 1, wherein the alkyl group of the alkyl glycoside emulsifier is one or more selected from the group consisting of lauryl, cocoyl, myristyl, cetyl, stearyl; the polyglycerol emulsifier is selected from one or more of lauryl, cocoyl, myristyl, cetyl and stearyl with glycerol polymerization degree of 6-10; the amino acid gemini surfactant has at least two hydrophobic hydrocarbon chains, two polar head groups and a linking group, and is selected from the group consisting of: one or more of arginine-based gemini surfactant, lysine-based gemini surfactant, cystine-based gemini surfactant and serine-based gemini surfactant; the lecithin and its modified emulsifier are selected from one or more of soybean lecithin, hydroxylated lecithin, hydrogenated lysolecithin and lysolecithin.
5. A nanoemulsion composition according to any one of claims 1-3, wherein the sum of the contents of both component (a) +component (B) is equal to or greater than 0.015%.
6. The nanoemulsion composition according to claim 5, wherein the sum of the contents of both component (a) +component (B) is not less than 0.1%.
7. The nanoemulsion composition according to claim 1, wherein the component (a): the compound weight ratio of the component (B) is more than or equal to 1:0.6.
8. a nanoemulsion composition according to any one of claims 1-3, wherein the component higher alcohol (B) is selected from one or more of octanol, decanol, lauryl alcohol, myristyl alcohol, stearyl alcohol, isostearyl alcohol, cetyl alcohol, oleyl alcohol, linoleyl alcohol, behenyl alcohol, undecyl alcohol, tridecyl alcohol, pentadecyl alcohol, heptadecyl alcohol, nonadecyl alcohol, and di-undecyl alcohol; the component (C) is selected from one or more of silicone oil, silica gel, modified substances thereof, fat, wax, hydrophobic plant extract, olefin, lipoid, liquid alcohol and essential oil; the component (D) is one or more selected from phytosterol, resveratrol, ceramide-like amine, coenzyme Q10, kojic dipalmitate, fullerene, glabridin, oil-soluble vitamin and derivatives thereof; the component (E) is one or more selected from glycerol, sorbitol, propylene glycol, butanediol, pentanediol, isopentyl glycol, hexanediol, glucose, maltose, maltitol, sucrose, fructose, xylitol, pentaerythritol and starch degrading sugar.
9. The nanoemulsion composition according to any one of claims 1-8, wherein the nanoemulsion composition using process can be one or several of high pressure homogenization in high energy emulsification, micro-jet or ultrasonic.
10. Use of the nanoemulsion composition according to any one of claims 1 to 9 for the preparation of cosmetics for the skin, scalp and hair, characterized in that: can be used alone to prepare into spray, gel, emulsion, ointment, and cream.
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| CN113730270B (en) * | 2021-10-08 | 2022-09-23 | 广州蝶恋花生物科技有限公司 | Nanoemulsion with anti-wrinkle effect prepared by using D-phase emulsification method and application thereof |
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| CN114681351A (en) * | 2022-04-01 | 2022-07-01 | 广州市娇兰化妆品有限公司 | Nanoemulsion of ceramide-like extract with triple effects and preparation method and application thereof |
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