CN107875028A - A kind of nanoemulsions spraying and preparation method thereof - Google Patents
A kind of nanoemulsions spraying and preparation method thereof Download PDFInfo
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- CN107875028A CN107875028A CN201711419464.6A CN201711419464A CN107875028A CN 107875028 A CN107875028 A CN 107875028A CN 201711419464 A CN201711419464 A CN 201711419464A CN 107875028 A CN107875028 A CN 107875028A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
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- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Colloid Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of spraying of nanoemulsions, it is characterised in that including following component：Oil phase part 0.1 5%；Aqueous phase portion 95 99.9%；Scent portion 0.01 0.5%；Wherein, the oil phase part, by weight percentage, following component is included：Nonionic surfactant 3 32%；Grease 22 58%；Polyalcohol 16 38%；Water surplus.The present invention is by controlling nonionic surfactant in oil phase part：Polyalcohol：Deionized water is that specific compound proportion is processed into oleogel in advance, then is aided with aqueous phase portion and the scent portion of certain content, and the nanoemulsions spraying being prepared can meet that consumer demand, atomizing effect are very soft, droplet is very tiny（100‑150nm）, injection wide-angle greatly up to 110 °；And the preparation technology of the present invention is simple, energy consumption is low, without high temperature and high pressure homogeneous, has good prospects for commercial application.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of nanoemulsions spraying and preparation method thereof.
Background technology
Presently commercially available skin care spraying is various in style, according to different efficacies have skin whitening, moisturizing, antiallergic to releive, smoothing wrinkle is anti-ageing,
Sage Extract, cleaning etc..But quality is uneven, there are some producers illegal in skin care item can add various hormones, antibiotic
Deng the disabling component in cosmetics regulation, although can make skin that glossy lubricating status temporarily be presented, long-term use can be unfavorable
In skin health.Meanwhile commercially available part skin care spray product usage experience and bad, during spraying, atomizing effect
Bad, injection wide-angle is small, and some can also have the dropping liquid phenomenon of leakage.For Artline is clean, reason skin spring, Vichy, Avene, Japan
Minon moist spray, wherein the injection wide-angle of 8 sections of binary valve sprayings on sale measures, it sprays wide-angle except Japan
Minon moist spraying wide-angles are 106 °, and others are all between 66 ° -99 °, wherein with the majority between 80 ° -90 °.
In addition, with the improvement of people's life quality, increasing demand of the people to skin care also gradually increases, it is desirable to make
With conveniently, skin sense is salubrious, and effect is obvious, to skin without any stimulation and burden etc..Cosmetic spray is as in skin-protection product
One big classification, it has the advantage that can be used whenever and wherever possible, gently very convenient toward on the face one spray, use.
Therefore, developing one kind can meet that consumer demand, atomizing effect are very soft, droplet is very tiny, injection
The big nanoemulsions spraying of wide-angle has important practical significance and application prospect.
The content of the invention
In view of this, primary and foremost purpose of the invention is to overcome above-mentioned the shortcomings of the prior art, there is provided one kind atomization
The nanoemulsions spraying that effect is very soft, droplet is very tiny, injection wide-angle is big.
Another object of the present invention is to provide the preparation method of above-mentioned nanoemulsions spraying, this method is simple, and energy consumption is low,
Without high temperature and high pressure homogeneous.
Nanoemulsions spraying of the present invention, including following component：
Oil phase part 0.1-5%；
Aqueous phase portion 95-99.9%；
Scent portion 0.01-0.5%；
Wherein, the oil phase part, by weight percentage, following component is included：
Nonionic surfactant 3-32%；
Grease 22-58%；
Polyalcohol 16-38%；
Water surplus.
Preferably, the nanoemulsions spraying, including following component：
Oil phase part 0.5-3%；
Aqueous phase portion 95-99.9%；
Scent portion 0.01-0.5%；
Wherein, the oil phase part, by weight percentage, following component is included：
Nonionic surfactant 16-24%；
Grease 31-38%；
Polyalcohol 26-33%；
Deionized water surplus.
Wherein, described nonionic surfactant is the surfactant of polyol type, and preferably PEG-60 hydrogenates castor
Sesame oil, PEG-20 iso stearic acid of glycerine ester, Natrulon H-10 isostearate or one kind or several in Natrulon H-10 dioleate
The mixing of kind.
Wherein, the grease is one or more of in the oil of artificial oil, mineral oil, silicone oil, hydrocarbon ils or plant origin
Mixing, preferably glycerine three（Thylhexoic acid）One or more of mixing in ester or caprylic/capric triglyceride.
Wherein, the polyalcohol is a kind of in glycerine, 1,3-BDO, 1,2-PD, 1,3-PD or diglycerol
Or several mixing, preferably glycerine or diglycerol.
Wherein, the aqueous phase portion is mixing one or more of in polyalcohol, deionized water and water-solubility function composition；Institute
Polyalcohol is stated as glycerine, 1,3-BDO, 1,2-PD, 1,3-PD, 1,2- hexylene glycols, 1,2- pentanediols, pungent glycol
Middle one or more of mixing；The water-solubility function composition for releived with antiallergic, whitening, moisturizing, crease-resistant, equilibrium oil lipid
It is at least a kind of in functional component；Preferably, the antiallergic releives class functional component as dipotassium glycyrrhizinate, bisabolol, dent
In amaranth extract, allantoin, cynara scolymus leaf extract, tuckahoe extracts, hamamelis extract, camomile extract it is a kind of or
Several mixing；The whitening class functional component be ursin, niacinamide, fructus crataegi cuneatae berry extract, wineberry berry extract,
One or more of mixing in Echinacea angustifolia extract；The moisturizing class functional component is that hyaluronic acid, dried tremella extract, Portugal gather
One or more of mixing in sugar, trehalose；The crease-resistant class functional component be adenosine, sugar Thallus Laminariae (Thallus Eckloniae) extract, palmitoyl oligopeptide,
One or more of mixing in Matrixyl -4, Argireline；The equilibrium oil lipid functional component is tartaric acid, glucose
One or more of mixing in sour zinc, Folium Aloe extract.
Wherein, the scent portion is the mixture of the oil, spices or these materials that are used as spices；Preferably essential oil.
Wherein, the nanoemulsions spraying is translucent or milky state, and its particle diameter is through the test of Malvern particle instrument
100-150nm, injection wide-angle are 110-115 °.
In addition, the invention also discloses the preparation method of above-mentioned nanoemulsions spraying, comprise the following steps：
（1）, oil phase part pre-processed, it is standby；
（2）, scent portion added into oil phase part, be well mixed；
（3）, by aqueous phase portion add step（2）, stir to produce and expect in nanoemulsions spraying；By in the spraying of gained nanoemulsions
Material by binary valve spray bottle it is filling after, produce nanoemulsions spraying；
Wherein, step（1）In, oil phase part pre-treatment step is as follows：
（1）By nonionic surfactant, polyalcohol, water, low-grade fever dissolving is well mixed in proportion, is designated as A, wherein nonionic table
Face activating agent：Polyalcohol：Water=（1.1~1.9）：（1.1~1.9）：（0.1~3）, the low-grade fever is the temperature not higher than 45 DEG C；
（2）Under A stirring conditions, grease is slowly added into, is designated as B；
（3）Under B stirring conditions, it will be slowly added into after remaining polynary alcohol and water premix, stir evenly and produce.
The present invention compared with prior art, has the advantages that：
（1）The present invention is by controlling nonionic surfactant in oil phase part：Polyalcohol：Deionized water is specific compound proportion,
And it is aided with aqueous phase portion and the scent portion of certain content, the nanoemulsions spraying being prepared can meet consumer demand, atomization
Effect is very soft, droplet is very tiny（100-150nm）, injection wide-angle be up to greatly（110-115°）, remote super large part is on sale
66-99 ° of the injection wide-angle of skin care spraying.
（2）The preparation technology of the present invention is simple, and energy consumption is low, without high temperature and high pressure homogeneous, has good commercial Application
Prospect.
Embodiment
The present invention is further illustrated below by embodiment, but embodiments of the present invention are not by following realities
Apply the limitation of example.
The embodiment of the present invention derives from purchased in market with the raw material used in comparative example.
The method of testing of average grain diameter：Nanoemulsions spraying is diluted to 2% solution with deionized water in advance, then uses horse
Your literary laser particle analyzer Mastersizer 3000 is determined.
The method of testing of spraying wide-angle：Spray when nanoemulsions spraying carries out spray injection is recorded by way of taking pictures
Firing angle, then it is to spray wide-angle to go out jet angle with angulation tolerance；Keep shooting angle, spray angle etc. all in the process taken pictures
Factor is consistent.
The evaluation method of the soft degree of atomizing effect：Scored, 5 points are best result, and score value is higher, and to represent atomizing effect soft
It is higher with spending.
The preparation method of oil phase part：
It is formulated by table 1 Suo Shi, nonionic surfactant, polyalcohol, water is well mixed in 40 DEG C of dissolvings in proportion, A is designated as,
Wherein nonionic surfactant：Polyalcohol：Water=（1.1~1.9）：（1.1~1.9）：（0.1~3）；Under A stirring conditions, by oil
Ester is slowly added into, and is designated as B；Under B stirring conditions, it will be slowly added into after remaining polynary alcohol and water premix, stir evenly and produce oil phase
Portion.
The proportioning of the oil phase part of table 1（Percentage by weight）
Embodiment 1-3 and comparative example 1-3：The preparation of nanoemulsions spraying
It is formulated by table 2 Suo Shi, first pre-processes oil phase part, it is standby；Then scent portion is added into oil phase part, be well mixed；Most
Aqueous phase portion is added afterwards, stirs to produce and expects in nanoemulsions spraying；Material in the spraying of gained nanoemulsions is passed through into binary valve
After spray bottle is filling, nanoemulsions spraying is produced, test performance result is as shown in table 2.
The embodiment of table 2 and comparative example with when the performance test results（Percentage by weight）
Claims (9)
1. a kind of nanoemulsions spraying, it is characterised in that including following component：
Oil phase part 0.1-5%；
Aqueous phase portion 95-99.9%；
Scent portion 0.01-0.5%；
Wherein, the oil phase part, by weight percentage, following component is included：
Nonionic surfactant 3-32%；
Grease 22-58%；
Polyalcohol 16-38%；
Water surplus.
2. nanoemulsions spraying according to claim 1, it is characterised in that the nanoemulsions spraying, including such as the following group
Point：
Oil phase part 0.5-3%；
Aqueous phase portion 95-99.9%；
Scent portion 0.01-0.5%；
Wherein, the oil phase part, by weight percentage, following component is included：
Nonionic surfactant 16-24%；
Grease 31-38%；
Polyalcohol 26-33%；
Deionized water surplus.
3. nanoemulsions according to claim 1 or 2 spraying, it is characterised in that described nonionic surfactant is
The surfactant of polyol type, preferably PEG-60 rilanit specials, PEG-20 iso stearic acid of glycerine ester, Natrulon H-10 are different
One or more of mixing in stearate or Natrulon H-10 dioleate.
4. nanoemulsions according to claim 1 or 2 spraying, it is characterised in that the grease be artificial oil, mineral oil,
One or more of mixing in the oil of silicone oil, hydrocarbon ils or plant origin, preferably glycerine three（Thylhexoic acid）Ester or octanoic acid/last of the ten Heavenly stems
One or more of mixing in acid glycerol three ester.
5. nanoemulsions spraying according to claim 1 or 2, it is characterised in that the polyalcohol is glycerine, 1,3- fourths two
One or more of mixing, preferably glycerine or diglycerol in alcohol, 1,2-PD, 1,3-PD or diglycerol.
6. nanoemulsions spraying according to claim 1 or 2, it is characterised in that the aqueous phase portion is polyalcohol, deionization
One or more of mixing in water and water-solubility function composition；The polyalcohol be glycerine, 1,3 butylene glycol, 1,2- propane diols,
1,3-PD, 1,2- hexylene glycols, 1,2- pentanediols, one or more of mixing in pungent glycol；The water-solubility function composition
To be releived with antiallergic, it is whitening, moisturizing, at least a kind of in crease-resistant, equilibrium oil lipid functional component；Preferably, the antiallergic
Class of releiving functional component is dipotassium glycyrrhizinate, bisabolol, purslane extract, allantoin, cynara scolymus leaf extract, Poria cocos extraction
One or more of mixing in thing, hamamelis extract, camomile extract；The whitening class functional component is black bearberry
One or more of mixing in glycosides, niacinamide, fructus crataegi cuneatae berry extract, wineberry berry extract, Echinacea angustifolia extract；Institute
Moisturizing class functional component is stated as mixing one or more of in hyaluronic acid, dried tremella extract, glucan, trehalose；It is described anti-
The class functional component of wrinkling be it is a kind of in adenosine, sugar Thallus Laminariae (Thallus Eckloniae) extract, palmitoyl oligopeptide, Matrixyl -4, Argireline or
Several mixing；The equilibrium oil lipid functional component is one or more of in tartaric acid, ZnG, Folium Aloe extract mixes
Close.
7. nanoemulsions spraying according to claim 1 or 2, it is characterised in that the scent portion is to be used as spices
Oil, the mixture of spices or these materials；Preferably essential oil.
8. nanoemulsions spraying according to claim 1 or 2, it is characterised in that the nanoemulsions spraying is translucent
Or milky state, its particle diameter are 100-150nm through the test of Malvern particle instrument, injection wide-angle is 110-115 °.
9. the preparation method of the nanoemulsions spraying according to claim any one of 1-8, it is characterised in that including following step
Suddenly：
（1）, oil phase part pre-processed, it is standby；
（2）, scent portion added into oil phase part, be well mixed；
（3）, by aqueous phase portion add step（2）, stir to produce and expect in nanoemulsions spraying；By in the spraying of gained nanoemulsions
Material by binary valve spray bottle it is filling after, produce nanoemulsions spraying；
Wherein, step（1）In, oil phase part pre-treatment step is as follows：
（1）By nonionic surfactant, polyalcohol, water, low-grade fever dissolving is well mixed in proportion, is designated as A, wherein nonionic table
Face activating agent：Polyalcohol：Water=（1.1~1.9）：（1.1~1.9）：（0.1~3）, the low-grade fever is the temperature not higher than 45 DEG C；
（2）Under A stirring conditions, grease is slowly added into, is designated as B；
（3）Under B stirring conditions, it will be slowly added into after remaining polynary alcohol and water premix, stir evenly and produce.
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| CN201711419464.6A CN107875028A (en) | 2017-12-25 | 2017-12-25 | A kind of nanoemulsions spraying and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846804A (en) * | 2019-01-29 | 2019-06-07 | 湖南海济药业有限公司 | A kind of method for extracting sheep embryo extract and the shin moisturizer containing sheep embryo extract |
| CN111643376A (en) * | 2020-06-15 | 2020-09-11 | 花安堂生物科技集团有限公司 | Nano-emulsion composition and application thereof |
| CN113730270A (en) * | 2021-10-08 | 2021-12-03 | 广州蝶恋花生物科技有限公司 | Nanoemulsion with anti-wrinkle effect prepared by using D-phase emulsification method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105813632A (en) * | 2013-08-23 | 2016-07-27 | 科丝美诗株式会社 | Method for preparing nano-emulsion |
| CN107137241A (en) * | 2017-05-23 | 2017-09-08 | 广州市花安堂生物科技有限公司 | A kind of microemulsion spraying and preparation method thereof |
-
2017
- 2017-12-25 CN CN201711419464.6A patent/CN107875028A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105813632A (en) * | 2013-08-23 | 2016-07-27 | 科丝美诗株式会社 | Method for preparing nano-emulsion |
| CN107137241A (en) * | 2017-05-23 | 2017-09-08 | 广州市花安堂生物科技有限公司 | A kind of microemulsion spraying and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109846804A (en) * | 2019-01-29 | 2019-06-07 | 湖南海济药业有限公司 | A kind of method for extracting sheep embryo extract and the shin moisturizer containing sheep embryo extract |
| CN111643376A (en) * | 2020-06-15 | 2020-09-11 | 花安堂生物科技集团有限公司 | Nano-emulsion composition and application thereof |
| CN111643376B (en) * | 2020-06-15 | 2023-04-25 | 花安堂生物科技集团有限公司 | Nanoemulsion composition and application thereof |
| CN113730270A (en) * | 2021-10-08 | 2021-12-03 | 广州蝶恋花生物科技有限公司 | Nanoemulsion with anti-wrinkle effect prepared by using D-phase emulsification method and application thereof |
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| CB02 | Change of applicant information |
Address after: 511434 No. 13, Liu Wei street, Hualong Town, Panyu District, Guangzhou, Guangdong Applicant after: Hua An Tang biotech Group Co., Ltd. Address before: 511434 No. 13, Liu Wei street, Hualong Town, Panyu District, Guangzhou, Guangdong Applicant before: City flower An Tang bio tech ltd, Guangzhou |
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