CN115429713A - Moisturizing, repairing and anti-aging composition containing ceramide and preparation method thereof - Google Patents
Moisturizing, repairing and anti-aging composition containing ceramide and preparation method thereof Download PDFInfo
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- CN115429713A CN115429713A CN202211248541.7A CN202211248541A CN115429713A CN 115429713 A CN115429713 A CN 115429713A CN 202211248541 A CN202211248541 A CN 202211248541A CN 115429713 A CN115429713 A CN 115429713A
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- ceramide
- moisturizing
- repairing
- composition containing
- aging
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- 229940106189 ceramide Drugs 0.000 title claims abstract description 41
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims abstract description 40
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 40
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 40
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 31
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000002502 liposome Substances 0.000 claims abstract description 17
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 16
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 15
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims abstract description 13
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 13
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims description 21
- 239000003921 oil Substances 0.000 claims description 17
- 239000003963 antioxidant agent Substances 0.000 claims description 15
- 230000003078 antioxidant effect Effects 0.000 claims description 15
- 235000006708 antioxidants Nutrition 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 15
- 239000000839 emulsion Substances 0.000 claims description 14
- 238000003756 stirring Methods 0.000 claims description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 claims description 5
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- 229940071160 cocoate Drugs 0.000 claims description 4
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 4
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 3
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 3
- 229940100556 laureth-23 Drugs 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229940105132 myristate Drugs 0.000 claims description 3
- 229920000223 polyglycerol Polymers 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 229940100458 steareth-21 Drugs 0.000 claims description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 3
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 239000002537 cosmetic Substances 0.000 abstract description 6
- 150000002148 esters Chemical class 0.000 abstract description 3
- 239000011248 coating agent Substances 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 abstract description 2
- 239000004530 micro-emulsion Substances 0.000 abstract description 2
- 239000002105 nanoparticle Substances 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 16
- 239000002245 particle Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 5
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of daily cosmetics, and provides a moisturizing, repairing and anti-aging composition containing ceramide, which comprises the following components in percentage by mass: 10 to 15 percent of glycerin, 5 to 10 percent of butanediol, 2 to 5 percent of phospholipid, 1 to 1.3 percent of ceramide NP, 0.2 to 0.5 percent of cholesterol, 2 to 5 percent of emulsifier and the balance of water to 100 percent. The invention utilizes the phospholipid liposome coating technology, takes phospholipid as a carrier to coat ceramide NP which is difficult to dissolve in oil ester and water in the liposome, and prepares the phospholipid ceramide liposome into the liposome transparent microemulsion with the nano-scale particle size, so that the coated ceramide can be directly applied to aqueous products and is stable and not separated out, and the moisturizing, repairing and anti-aging composition containing ceramide has the advantages of good stability and convenient use, and can be well applied to cosmetics.
Description
Technical Field
The invention relates to the technical field of daily cosmetics, in particular to a moisturizing, repairing and anti-aging composition containing ceramide and a preparation method thereof.
Background
Ceramides are lipids naturally present in the skin and form a water-resistant barrier on the skin surface, which protects the skin better and makes it moist and tender. The ceramide NP from biological fermentation is a new generation skin moisturizer developed in recent years, can maintain the moisture retention of skin, repair dry and damaged skin and promote the renewal of natural protective layers of the skin. Currently, the active ingredients are widely applied to skin care cosmetics as an effective skin care active ingredient.
The important premise for realizing the skin care effect is that the active ingredients can effectively penetrate through the surface layer of the skin, and are enriched at high concentration in skin tissues and retained for a long time, namely, the targeted delivery of the skin care active ingredients is realized.
Most of the currently marketed ceramide cosmetic formulations are common creams, and the active ingredients have poor skin permeability and low retention. Meanwhile, the ceramide NP is a high-crystallinity substance, has poor dispersibility in water and most of oily esters, has extremely low solubility, is easy to crystallize and separate out in the standing process, and is not beneficial to the absorption of active substances and the stability of products. Therefore, there is a need for further studies on the absorption and stability of ceramide to be more effectively applied to the cosmetic field.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a moisturizing, repairing and anti-aging composition containing ceramide, and the moisturizing, repairing and anti-aging composition has the advantages of good water dispersibility, good stability, high transparency of an aqueous dispersion and good transdermal absorption.
In order to achieve the purpose, the invention adopts the following technical scheme:
a moisturizing, repairing and anti-aging composition containing ceramide comprises the following components in percentage by mass:
optionally, the composition comprises the following components in percentage by mass:
optionally, the emulsifier is one or more of PEG-20 sorbitan cocoate, PEG-40 hydrogenated castor oil, polyglycerol 10 myristate, laureth-23, steareth-21, and Tween 80.
Optionally, the antioxidant also comprises 0.1-1% by mass, and the antioxidant is one or more of vitamin C, vitamin E, coenzyme Q10 and idebene.
A preparation method of a moisturizing, repairing and anti-aging composition containing ceramide comprises the following steps:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating, stirring, and making into oil phase;
(2) Mixing water, glycerol and butanediol at a certain proportion, and heating to obtain water phase;
(3) Adding the heated water phase into the oil phase, quickly and uniformly stirring, and homogenizing for 3-5 min to prepare emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under the pressure of 800-1500 bar to obtain a transparent ceramide liposome solution;
(5) Cooling, adding appropriate amount of antiseptic, and mixing to obtain the final product.
Optionally, both the oil phase in the step (1) and the water phase in the step (2) are heated to 80-85 ℃.
Optionally, the preservative in step (5) is a mixture of caprylhydroxamic acid and ethylhexyl glycerin.
The beneficial effects of the invention are as follows: 1) The invention utilizes the phospholipid liposome coating technology, takes phospholipid as a carrier to coat ceramide NP which is difficult to dissolve in oil ester and water in the liposome, and prepares the phospholipid ceramide liposome into liposome transparent microemulsion with the nano-scale particle size, so that the coated ceramide can be directly applied to aqueous products and is stable without precipitation, and meanwhile, the ceramide NP which takes the nano-phospholipid liposome as the carrier is easier to penetrate and absorb on the skin epidermis. 2) The preparation method is simple and controllable, and has good repeatability.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention as claimed is not limited to the scope of the examples.
The mass percentage distribution ratio and the preparation parameters of the components in the moisturizing, repairing and anti-aging composition containing ceramide are shown in the following table 1:
TABLE 1 formulation data Table for different examples
The moisturizing, repairing and anti-aging composition containing ceramide of example 1 is prepared by the following steps:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating to 80 deg.C, and stirring to obtain oil phase; wherein the emulsifier is PEG-20 sorbitan cocoate, and the antioxidant is vitamin E.
(2) Mixing water, glycerol, and butanediol at a certain proportion, heating to 80 deg.C, and making into water phase.
(3) Adding the heated water phase into the oil phase, rapidly stirring, homogenizing for 3min to obtain emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under the pressure of 800bar to obtain a transparent ceramide liposome solution;
(5) Cooling to 45 deg.C, adding antiseptic composed of caprylyl hydroximic acid and ethylhexyl glycerol, and mixing to obtain the final product.
The moisturizing, repairing and anti-aging composition containing ceramide in example 2 is prepared by the following steps:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating to 85 deg.C, and stirring to obtain oil phase; wherein the emulsifier is PEG-40 hydrogenated castor oil, and the antioxidant is coenzyme Q10.
(2) Mixing water, glycerol, and butanediol at a certain proportion, heating to 85 deg.C, and making into water phase.
(3) Adding the heated water phase into the oil phase, rapidly stirring, homogenizing for 5min, and making into emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under the pressure of 1000bar to obtain a transparent ceramide liposome solution;
(5) Cooling to 45 deg.C, adding antiseptic composed of caprylhydroxamic acid and ethylhexyl glycerol, and mixing well to obtain the final product.
The moisturizing, repairing and anti-aging composition containing ceramide in example 3 is prepared by the following steps:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating to 85 deg.C, and stirring to obtain oil phase; wherein the emulsifier is a mixture of PEG-20 sorbitan cocoate and PEG-40 hydrogenated castor oil in a ratio of 1.
(2) Mixing water, glycerol and butanediol at a certain proportion, heating to 85 deg.C, and making into water phase.
(3) Adding the heated water phase into the oil phase, rapidly stirring, homogenizing for 5min, and making into emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under the pressure of 1200bar to obtain a transparent ceramide liposome solution;
(5) Cooling to 45 deg.C, adding antiseptic composed of caprylhydroxamic acid and ethylhexyl glycerol, and mixing well to obtain the final product.
The moisturizing, repairing and anti-aging composition containing ceramide of example 4 is prepared by the following steps:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating to 85 deg.C, and stirring to obtain oil phase; wherein the emulsifier is a mixture of laureth-23, steareth-21 and tween 80, and the antioxidant is a mixture of vitamin E and coenzyme Q10.
(2) Mixing water, glycerol and butanediol at a certain proportion, heating to 85 deg.C, and making into water phase.
(3) Adding the heated water phase into the oil phase, rapidly stirring, homogenizing for 5min, and making into emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under the pressure of 1200bar to obtain a transparent ceramide liposome solution;
(5) Cooling to 45 deg.C, adding capryl hydroximic acid antiseptic, and mixing to obtain the final product.
The moisturizing, repairing and anti-aging composition containing ceramide in example 5 is prepared by the following steps:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating to 85 deg.C, and stirring to obtain oil phase; wherein the emulsifier is polyglycerol 10 myristate, and the antioxidant is idebene.
(2) Mixing water, glycerol, and butanediol at a certain proportion, heating to 85 deg.C, and making into water phase.
(3) Adding the heated water phase into the oil phase, rapidly stirring, homogenizing for 5min, and making into emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under 1500bar pressure to obtain transparent ceramide liposome solution;
(5) Cooling to 45 deg.C, adding ethylhexyl glycerol as antiseptic, and mixing to obtain the final product.
Particle size measurement
The size and the distribution of the particle size are very important to the stability of the system, so that the stability of the moisturizing and repairing anti-aging composition system containing ceramide can be intuitively reflected by continuously detecting the particle size in different time periods.
Table 2 shows the average particle size data of different moisturizing and rejuvenating anti-aging compositions containing ceramide (samples of examples 1 to 5) stored at room temperature for 1 to 28 days.
Table 2: particle size and appearance data sheet for different examples
As can be seen from table 2, the particle size of the moisturizing, repairing and anti-aging composition containing ceramide prepared in examples 1 to 5 is about 200nm, the average particle size increases with the time, the increase of the homogenization pressure is beneficial to delaying the aggregation of phospholipid ceramide liposome molecules, and when the homogenization pressure is 1500bar, the particle size of the moisturizing, repairing and anti-aging composition containing ceramide according to the present invention changes minimally, so a high homogenization pressure should be selected during homogenization.
Moisturizing repair test
The moisturizing, repairing and anti-aging compositions containing ceramide prepared in examples 1 to 5 were dispersed in serum at an addition amount of 10%, 50 patients with mild hormone-dependent disease history (red and swollen skin, itching and pain) were randomly divided into 5 groups of 10 patients each, sprayed once in the morning and evening, and tested for TEWL values before and after use after 7 consecutive days; among them, TEWL refers to transdermal water loss, and is one of the indexes for evaluating the skin barrier function. When barrier function is impaired, the TEWL value increases; conversely, when the TEWL value decreases, barrier repair is suggested.
Wherein the rate of change = (after use-before use)/100% before use, and a smaller rate of change indicates a slower water loss and a better barrier function of the skin.
Table 3: moisturizing data sheet of various embodiments
| Essential water group | Before use | After use | Rate of change (%) |
| Example 1 | 25.51 | 20.35 | -20.23％ |
| Example 2 | 23.54 | 17.24 | -26.76％ |
| Example 3 | 28.15 | 20.87 | -25.86％ |
| Example 4 | 29.53 | 21.68 | -26.58％ |
| Example 5 | 26.25 | 21.45 | -18.29％ |
From table 3, it can be seen that: the skin of a patient can be obviously improved by adding the essence water of the moisturizing, repairing and anti-aging composition of 10 percent, and the moisturizing, repairing and repairing effects of the composition are proved to be in line with expectations.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (7)
1. The moisturizing, repairing and anti-aging composition containing ceramide is characterized by comprising the following components in percentage by mass:
2. the moisturizing, repairing and anti-aging composition containing ceramide as claimed in claim 1, which is characterized by comprising the following components in percentage by mass:
3. the moisturizing, repairing and antiaging composition containing ceramide as claimed in claim 1 or 2, wherein the emulsifier is one or more selected from PEG-20 sorbitan cocoate, PEG-40 hydrogenated castor oil, polyglycerol 10 myristate, laureth-23, steareth-21, and Tween 80.
4. The moisturizing, repairing and anti-aging composition containing ceramide as claimed in claim 1 or 2, further comprising 0.1-1% by mass of an antioxidant, wherein the antioxidant is one or more of vitamin C, vitamin E, coenzyme Q10 and idebene.
5. A method for preparing the moisturizing, repairing and anti-aging ceramide-containing composition as claimed in any one of claims 1 to 4, comprising the steps of:
(1) Proportionally mixing phospholipid, emulsifier, ceramide NP, cholesterol and antioxidant, heating, stirring, and making into oil phase;
(2) Mixing water, glycerol, and butanediol at a certain proportion, and heating to obtain water phase;
(3) Adding the heated water phase into the oil phase, quickly stirring uniformly, and homogenizing for 3-5 min to prepare emulsion;
(4) Circulating the emulsion for 3 times by a high-pressure homogenizer under the pressure of 800-1500 bar to obtain a transparent ceramide liposome solution;
(5) Cooling, adding appropriate amount of antiseptic, and mixing to obtain the final product.
6. The preparation method of moisturizing, repairing and anti-aging ceramide-containing composition according to claim 5, wherein: heating the oil phase in the step (1) and the water phase in the step (2) to 80-85 ℃.
7. The method for preparing the moisturizing, repairing and anti-aging ceramide composition as claimed in claim 5, wherein the composition comprises: the preservative in the step (5) is a mixture of caprylhydroxamic acid and ethylhexyl glycerin.
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