CN117084944B - Skin conditioner composition and method of making the same - Google Patents

Skin conditioner composition and method of making the same Download PDF

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Publication number
CN117084944B
CN117084944B CN202311347657.0A CN202311347657A CN117084944B CN 117084944 B CN117084944 B CN 117084944B CN 202311347657 A CN202311347657 A CN 202311347657A CN 117084944 B CN117084944 B CN 117084944B
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oil
retinol
skin conditioning
skin
seed oil
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CN117084944A (en
Inventor
邬青云
舒鹏
王浪
盛伊娜
周献冬
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Shenzhen Hujia Technology Co ltd
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Shenzhen Hujia Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a skin conditioning composition and a method of preparing the same. Skin conditioning compositions include dimethicone, retinol compounds, and oils. Wherein the weight percentage content of the polydimethylsiloxane is 20-80%; the weight percentage content of the retinol compound is 0.001-10%; the retinol-like compounds include retinol and/or derivatives of retinol; the oil is immiscible with the polydimethylsiloxane, which is the continuous phase; the oil is mutually dissolved with the retinol and/or the retinol derivative to form a disperse phase, so as to form oil globules, and the particle size of the oil globules is 90-2000 microns. The invention provides a skin conditioner composition which has good appearance, good stability of retinol compounds and convenient preservation.

Description

Skin conditioner composition and method of making the same
Technical Field
The invention relates to the technical field of cosmetics, in particular to a skin conditioner composition and a preparation method thereof.
Background
When retinol or retinol esters penetrate the skin, they are gradually metabolized to retinoic acid under the oxidative action of enzymes, which in turn acts to promote epidermal cell turnover. Retinoic acid is slowly released on the skin through the metabolic process, so that the skin is prevented from being strongly stimulated, and the effect of activating cell renewal is achieved. Retinol and its derivatives have effects of preventing collagen decomposition and stimulating skin fibroblast to synthesize collagen, and can be applied to skin to exert antiaging effect.
However, retinol has poor stability and is easily decomposed by light and heat, especially under the action of ultraviolet rays, and is more easily catalyzed and decomposed; in addition, retinol has lipid solubility and poor solubility in water. Thus, retinol has disadvantages of instability and low availability in cosmetics, and cannot be stably present in cosmetics and slowly released on the skin.
Accordingly, improvements are needed in the art.
Disclosure of Invention
In the prior art, retinol has the defects of instability and low utilization rate in cosmetics, and cannot be stably existing in the cosmetics and slowly released on the skin, so the invention provides a skin conditioner composition and a preparation method thereof, which are used for solving the problems.
To achieve the above object, in a first aspect, the present invention provides a skin conditioning composition comprising polydimethylsiloxane, a retinoid and an oil; wherein,
the weight percentage content of the polydimethylsiloxane is 20-80%;
the weight percentage content of the retinol compound is 0.001-10%;
the retinol-like compounds include retinol and/or derivatives of retinol;
the oil is immiscible with the polydimethylsiloxane, which is the continuous phase;
the oil is mutually dissolved with the retinol and/or the retinol derivative to form a disperse phase, so as to form oil globules, and the particle size of the oil globules is 90-2000 microns.
In one implementation, the oil has a density of 0.810 to 0.970.
In one implementation, the polydimethylsiloxane has a viscosity of 0 to 2000 mpa.s.
In one implementation, the oil comprises any one or more of peony seed oil, macadamia nut seed oil, sandalwood seed oil, white pool flower seed oil, berk seed oil, rosewood seed oil, wild soybean oil, cranberry seed oil, spiny tree seed oil, avocado oil, olive fruit oil, monkey seed oil, grape seed oil, and jojoba seed oil.
In one implementation, the skin conditioner composition further comprises an antioxidant comprising any one or more of pentaerythritol tetrakis (di-t-butylhydroxyhydrocinnamate), tocopherol, tocopheryl acetate, ascorbyl tetraisopalmitate, bakuchiol, phytol, and dimethylmethoxychromanol.
In one implementation, the skin conditioner composition further comprises a thickener comprising any one or more of dextrin palmitate and castor oil/IPDI copolymer.
In one implementation, the skin conditioning composition further comprises a conditioning agent comprising one or more of lactic acid, citric acid, sodium bicarbonate, essential oils, and fragrances.
In one implementation, the skin conditioning composition further comprises a viscosity modifier comprising hydroxyethylcellulose or carbomers.
In a second aspect, the present invention also provides a method of preparing a skin conditioning composition for use in preparing the above skin conditioning composition, comprising the steps of:
s1, adding a regulator and a stabilizer into polydimethylsiloxane, and heating to dissolve and uniformly mix the regulator and the stabilizer; wherein, the weight percentage of the regulator is 0.01-2 percent, and the weight percentage of the stabilizer is 0-2 percent;
s2, placing the retinol compound into oil, and mixing until the retinol compound is completely dissolved;
s3, slowly adding a solution containing retinol compounds into the polydimethylsiloxane solution, and continuously stirring at the same time to fully mix the two substances;
s4, cooling the mixed solution to room temperature to form an oil gel system;
s5, after the oil gel system is formed, adding a thickening agent and a preservative to obtain a required skin conditioning composition; wherein the weight percentage of the thickening agent is 0.05-2%, and the weight percentage of the preservative is 0-2%.
In one implementation mode, in the step S1, the temperature is heated to 80-90 ℃, and the stabilizer comprises any one of an emulsifier, an antioxidant, a preservative and a viscosity regulator.
The beneficial effects are that: the skin conditioner composition provided by the invention forms a disperse phase by setting oil to be mutually soluble with the retinol and/or the retinol derivative to form oil globules, so that the retinol and/or the retinol derivative is at least partially wrapped by the oil and is jointly dispersed in polydimethylsiloxane with the oil, the direct and complete contact between the disperse oil phase containing retinol and an oxidizing environment can be effectively avoided, and the activity loss of retinol or retinol derivative is reduced; retinol and/or retinol derivatives and oil are dispersed in polydimethylsiloxane to form tiny particle oil beads, so that the tiny particle oil beads existing in the tiny particle oil beads can be visually seen, and the tiny particle oil beads have attractive appearance; a skin conditioner composition is provided which has good appearance, good stability of retinol compounds and convenient preservation.
Drawings
Fig. 1 is a flow chart of the steps of a method of preparing a skin conditioning composition provided by the present invention.
The achievement of the objects, functional features and advantages of the present invention will be further described with reference to the accompanying drawings, in conjunction with the embodiments.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. Furthermore, the descriptions of the terms "one embodiment," "some embodiments," "examples," "particular examples," or "some examples," etc., described below mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms are not necessarily for the same embodiment or example. The technical features of the respective embodiments of the present invention may be combined with each other as long as they do not collide with each other.
All percentages and ratios used herein are by weight of the total composition unless otherwise indicated. All measurements are understood to be performed under ambient conditions, unless otherwise indicated, where "ambient conditions" refers to conditions at about 25 ℃, at about one atmosphere, and at about 50% relative humidity. All numerical ranges are narrower ranges inclusive; the upper and lower limits of the described ranges are combinable to form additional ranges not explicitly described.
The present invention provides a skin conditioning composition comprising polydimethylsiloxane, retinol-like compounds and oil; wherein,
the weight percentage content of the polydimethylsiloxane is 20-80%;
the weight percentage content of the retinol compound is 0.001-10%;
the retinol compounds comprise retinol and/or retinol derivatives, wherein the retinol derivatives refer to esters, ethers, amides, hydroxy groups and/or salt structural analogues of retinol.
The oil is immiscible with the polydimethylsiloxane, which is the continuous phase;
the oil is mutually dissolved with the retinol and/or the retinol derivative to form a disperse phase, so as to form oil globules, and the particle size of the oil globules is 90-2000 microns.
Further, the density of the oil is 0.810-0.970. The oil comprises any one or more of peony seed oil, all-edge leaf macadamia nut seed oil, sandalwood seed oil, white pool flower seed oil, berk walnut seed oil, rosewood seed oil, wild soybean oil, sichuan chinaroot greenbrier rhizome seed oil, avocado oil, olive fruit oil, monkey bread seed oil, grape seed oil and jojoba seed oil. In the present invention, the oil is a natural oil, contains rich nutrients such as fatty acids and antioxidants, can provide more nourishment and protection to the skin, can provide nutrition and protection to the skin, and can cooperate with the retinol compound to realize the conditioning effect of the skin conditioner, so that in embodiments, the skin conditioner composition can be used without adding other antioxidants.
The viscosity of the polydimethylsiloxane is 0-2000 mPa.s.
The skin conditioner composition further comprises an antioxidant comprising any one or more of pentaerythritol tetrakis (di-t-butylhydroxyhydrocinnamate), tocopherol, tocopheryl acetate, ascorbyl tetraisopalmitate, bakuchiol, phytol, and dimethylmethoxychromanol. Preferably, the antioxidant is 0-2% by weight.
The skin conditioning composition further comprises a thickener comprising any one or more of dextrin palmitate and castor oil/IPDI copolymer. Preferably, the weight percentage of the thickener is 0.05-2%.
The conditioning agent includes a pH conditioning agent and/or a sensory modifier. Wherein the pH adjuster comprises any one of lactic acid, citric acid, sodium bicarbonate, arginine, sodium hydroxide, potassium hydroxide, glycolic acid and triethanolamine, for maintaining the optimal pH of the skin conditioner composition, thereby ensuring its effectiveness and stability. The sensory modifier comprises an essential oil or fragrance for enhancing the sensory experience of the skin conditioner composition. Preferably, the weight percentage of the regulator is 0.01% -2%.
The skin conditioning composition further comprises a viscosity modifier comprising hydroxyethylcellulose or carbomers. Preferably, the weight percentage of the viscosity modifier is 0.01-2%.
The invention also provides a preparation method of the skin conditioner composition, which is used for preparing the skin conditioner composition and specifically comprises the following steps of:
s1, adding a regulator and a stabilizer formula into polydimethylsiloxane, and heating to dissolve and uniformly mix the components; wherein, the weight percentage of the regulator is 0.01-2 percent, and the weight percentage of the stabilizer is 0-2 percent;
s2, placing the retinol compound into oil, and mixing until the retinol compound is completely dissolved;
s3, slowly adding a solution containing retinol compounds into the polydimethylsiloxane solution, and continuously stirring at the same time to fully mix the two substances;
s4, cooling the mixed solution to room temperature to form an oil gel system;
s5, after the oil gel system is formed, adding a thickening agent and a preservative to obtain a required skin conditioning composition; wherein the weight percentage of the thickening agent is 0.05-2%, and the weight percentage of the preservative is 0-2%.
In the step S1, heating to 80-90 ℃, wherein the stabilizer comprises any one of an emulsifying agent, an antioxidant, a preservative and a viscosity regulator. Wherein the emulsifier comprises polysorbate or cetyl alcohol for maintaining stable emulsion. The antioxidant comprises any one or more of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), tocopherol, tocopheryl acetate, ascorbyl tetraisopalmitate, bakuchiol, phytol and dimethylmethoxy chromanol for preventing oxidation of the active ingredient in the skin conditioner composition, thereby extending its shelf life. The preservative comprises a paraben or ethylhexyl glycerol for preventing microbial growth, ensuring the safety of the skin conditioning composition. The viscosity modifier comprises hydroxyethyl cellulose or carbomer for adjusting the viscosity of the skin conditioning composition to improve its application properties.
In S5, further comprising heating and adding other elements, such as thickeners, lubricants and/or preservatives, etc., after the formation of the oleogel system to achieve a specific texture and feel, and performing performance tests to confirm its stability.
Experiments were performed in this example to verify the performance of the skin conditioner composition.
The specific contents of example 1 and example 2 are shown in table 1:
in this experimental example 1 and example 2, oil globules could be formed, whereas in experimental example 3, oil globules could not be formed.
The specific contents of example 1, comparative example 1 and comparative example 2 are shown in table 2:
the skin conditioning compositions of example 1, comparative example 1 and comparative example 2 were tested in this example, and the test details specifically included:
1. centrifugal stability: each test piece was centrifuged at 3000 rpm/min for 30 min, and the state of each test piece was observed.
2. High temperature stability: each test piece was left at 48℃for 1 month, and the state of each test piece was observed.
3. Low temperature stability: each test piece was left at-15℃for 1 month, and the state of each test piece was observed.
4. High-low temperature alternating stability: the conditions of each experimental example were observed by alternately carrying out the experiments at-15℃and 48℃for 1 month, respectively, and the observation results are shown in Table 3.
5. Stability test of actives: the skin conditioner compositions provided for each of the experimental and comparative examples were opened 2 times per day for 1 time for 1 minute to simulate a consumer's use scenario, and the weight percent content change of retinol after 0 days, 1 month, and 2 months was measured, and the test results are shown in table 4:
；
as can be seen from the data in tables 3 and 4, the oil gel system provided by the present invention is effective in preventing oxidation of retinol, has good stability and is convenient for storage, relative to pure oil systems and oil-in-water systems.
In summary, the skin conditioner composition provided by the invention forms a dispersed phase by setting oil to be mutually soluble with the retinol and/or the retinol derivative to form oil globules, so that the retinol and/or the retinol derivative is at least partially wrapped by the oil, and is jointly dispersed in polydimethylsiloxane with the oil, thus being capable of effectively avoiding direct and complete contact between the retinol-containing dispersed oil phase and an oxidizing environment, and further reducing activity loss of the retinol or retinol derivative; retinol and/or retinol derivatives and oil are dispersed in polydimethylsiloxane to form tiny particle oil beads, so that the tiny particle oil beads existing in the tiny particle oil beads can be visually seen, and the tiny particle oil beads have attractive appearance; a skin conditioner composition is provided which has good appearance, good stability of retinol compounds and convenient preservation. In addition, the polydimethylsiloxane in the skin conditioner composition can provide a greasy touch feeling, and the oil droplets can enhance the moisturizing effect.
The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes using the descriptions and drawings of the present invention or directly or indirectly applied to other related technical fields are included in the scope of the invention.

Claims (7)

1. A skin conditioning composition comprising polydimethylsiloxane, retinol compounds and oil; wherein,
the weight percentage content of the polydimethylsiloxane is 20-80%;
the weight percentage content of the retinol compound is 0.001-10%;
the retinol-like compounds include retinol and/or derivatives of retinol;
the oil is immiscible with the polydimethylsiloxane, which is the continuous phase;
the oil is mutually dissolved with the retinol and/or the retinol derivative to form a disperse phase to form oil globules, the particle size of the oil globules is 90-2000 microns, and the skin conditioner composition is an oil gel system;
the skin conditioning composition further comprises a thickener, wherein the weight percentage content of the thickener is 0.05% -2%;
the skin conditioning composition further comprises a regulator, wherein the regulator comprises a pH regulator and/or a sensory improver, and the content of the regulator is 0.01% -2%;
the skin conditioning composition further comprises a viscosity regulator, wherein the content of the viscosity regulator is 0.01% -2%.
2. The skin conditioning composition of claim 1 wherein the oil has a density of 0.810 to 0.970.
3. The skin conditioner composition of claim 1, wherein the oil comprises any one or more of peony seed oil, macadamia nut seed oil, sandalwood seed oil, white pool flower seed oil, berk nut seed oil, rosewood seed oil, wild soybean oil, cranberry seed oil, spiny tree kernel oil, avocado oil, olive fruit oil, monkey seed oil, grape seed oil, and jojoba seed oil.
4. The skin conditioning composition of claim 1, further comprising an antioxidant comprising any one or more of pentaerythritol tetrakis (di-t-butylhydroxyhydrocinnamate), tocopherol, tocopheryl acetate, ascorbyl tetraisopalmitate, bakuchiol, phytol, and dimethylmethoxy chromanol.
5. The skin conditioning composition of claim 1 wherein the thickener comprises any one or more of dextrin palmitate and castor oil/IPDI copolymer.
6. The skin conditioning composition of claim 1 wherein the conditioning agent comprises one or more of lactic acid, citric acid and sodium bicarbonate.
7. The skin conditioning composition of claim 1 wherein the viscosity modifier comprises hydroxyethylcellulose or carbomers.
CN202311347657.0A 2023-10-18 2023-10-18 Skin conditioner composition and method of making the same Active CN117084944B (en)

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CN117084944B true CN117084944B (en) 2024-03-19

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1553794A (en) * 2000-12-28 2004-12-08 Stable skin conditioning compositions containing retinoid boosters
CN1638725A (en) * 2002-03-04 2005-07-13 宝洁公司 Stable personal care compositions containing a retinoid
CN112107506A (en) * 2020-09-30 2020-12-22 广州市科能化妆品科研有限公司 Retinols wrap and preparation method and application thereof
CN114617780A (en) * 2020-12-11 2022-06-14 伽蓝（集团）股份有限公司 Retinol derivative oily gel beads, skin care composition containing oily gel beads and preparation method
CN116251035A (en) * 2023-03-17 2023-06-13 深圳市护家科技有限公司 Oily composition containing retinol and/or retinol derivatives
CN116270297A (en) * 2023-03-16 2023-06-23 深圳市护家科技有限公司 Three-phase composition containing retinol and external skin preparation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1553794A (en) * 2000-12-28 2004-12-08 Stable skin conditioning compositions containing retinoid boosters
CN1638725A (en) * 2002-03-04 2005-07-13 宝洁公司 Stable personal care compositions containing a retinoid
CN112107506A (en) * 2020-09-30 2020-12-22 广州市科能化妆品科研有限公司 Retinols wrap and preparation method and application thereof
CN114617780A (en) * 2020-12-11 2022-06-14 伽蓝（集团）股份有限公司 Retinol derivative oily gel beads, skin care composition containing oily gel beads and preparation method
CN116270297A (en) * 2023-03-16 2023-06-23 深圳市护家科技有限公司 Three-phase composition containing retinol and external skin preparation
CN116251035A (en) * 2023-03-17 2023-06-13 深圳市护家科技有限公司 Oily composition containing retinol and/or retinol derivatives

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