CN104546516A - Preparation process and application of compound ceramide liposome - Google Patents
Preparation process and application of compound ceramide liposome Download PDFInfo
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- CN104546516A CN104546516A CN201410787026.5A CN201410787026A CN104546516A CN 104546516 A CN104546516 A CN 104546516A CN 201410787026 A CN201410787026 A CN 201410787026A CN 104546516 A CN104546516 A CN 104546516A
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- ceramide
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- composite nerve
- amide lipid
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Abstract
The invention discloses a preparation process and application of compound ceramide liposome. The preparation process disclosed by the invention comprises the following steps of uniformly mixing 10-60% by weight of glycerinum, 0.1-0.5% by weight of cholesterol, 0.1-0.5% by weight of salicyloyl Phytosphingosine, 0.1-0.5% by weight of ceramide VI, 0.1-0.6% by weight of ceramide IIIB, 0.5-3% by weight of hydrogenated phospholipid, 1-5% by weight of octyldodecanol, and 1-20% by weight of dipropylene glycol at 70-90 DEG C, adding 5-50% by weight of water into the mixed solution, uniformly stirring, and processing through a high-pressure homogenizer so as to obtain the transparent compound ceramide liposome, wherein the high-pressure homogenizing pressure is 600-1000 bar; and the cycle number is 2-5. The compound ceramide liposome disclosed by the invention is high in stability and good in water dispersibility and biocompatibility, and can be freely matched with cosmetic formulae at normal temperature; and the preparation method is simple, controllable and good in repeatability.
Description
Technical field
The present invention relates to cosmetic field, especially relate to a kind of preparation technology and application of composite nerve amide lipid body.
Background technology
Ceramide, also known as sphingolipid, is a kind of lipid being present in skin, plays an important role in epidermal keratinocytes layer formation process.It is close with the structure of matter forming keratodermatitis, can penetrate into skin very soon, and the water in horny layer combines, and forms a kind of network structure, pins moisture.Research in recent years shows, when drying, desquamation, cracking phenomena appear in skin, when its barrier function obviously reduces, skin supplements ceramide can recover rapidly moisturizing and barrier function.
Strengthen along with the age and enter the geratic period, the ceramide existed in human body skin can reduce gradually, the appearance of the skin abnormality symptoms such as dry skin and coarse skin type is also that therefore will prevent this kind of skin abnormality, supplementary ceramide is comparatively ideal way caused by ceramide amount reduces.
But ceramide emulsion intercalation method and the water dispersible of general preparation are at present all poor, are difficult to directly apply to the problems such as cosmetics.
Summary of the invention
Object of the present invention is exactly to solve the problem; a kind of preparation technology and application of composite nerve amide lipid body are provided; the method can obtain the composite nerve amide lipid body that stability is high, water dispersible is good; and ceramide is carried out pre-emulsification; successfully obtain and form on all four lipoid concentrated solution with skin; the protective barrier function of skin can be repaired, simultaneously also more convenient in application.
To achieve these goals, the present invention adopts following technical scheme:
Composite nerve amide lipid body, it is made up of following component by weight percentage: glycerol 10% ~ 60%; Cholesterol 0.1% ~ 0.5%; Salicyloyl phytosphingosine 0.1% ~ 0.5%; Ceramide VI 0.1% ~ 0.5%; Ceramide IIIB 0.1% ~ 0.6%; Hydrogenated phospholipid 0.5% ~ 3%; Octyl dodecanol 1% ~ 5%; Dipropylene glycol 1% ~ 20%; Surplus is water.
Be as to further optimization of the present invention, composite nerve amide lipid body, it is made up of following component by weight percentage: glycerol 50%; Cholesterol 0.2%; Salicyloyl phytosphingosine 0.2%; Ceramide VI0.2%; Ceramide IIIB 0.2%; Hydrogenated phospholipid 1%; Octyl dodecanol 2%; Dipropylene glycol 5%; Surplus is water.
Be as to further optimization of the present invention, composite nerve amide lipid body, it is made up of following component by weight percentage: glycerol 60%; Cholesterol 0.5%; Salicyloyl phytosphingosine 0.5%; Ceramide VI0.5%; Ceramide IIIB 0.5%; Hydrogenated phospholipid 3%; Octyl dodecanol 5%; Dipropylene glycol 15%; Surplus is water.
Be as to further optimization of the present invention, composite nerve amide lipid body, it is made up of following component by weight percentage: glycerol 30%; Cholesterol 0.5%; Salicyloyl phytosphingosine 0.5%; Ceramide VI0.5%; Ceramide IIIB 0.5%; Hydrogenated phospholipid 3%; Octyl dodecanol 5%; Dipropylene glycol 20%; Surplus is water.
Prepare the technique of composite nerve amide lipid body, comprise the steps:
S1, by glycerol, cholesterol, salicyloyl phytosphingosine, ceramide VI, ceramide IIIB, hydrogenated phospholipid, octyl dodecanol, dipropylene glycol mix homogeneously under 70 ~ 90 DEG C of conditions, obtain mixed solution A;
S2, add water to mixed solution A, stir, by high pressure homogenizer process, wherein, high pressure homogenize pressure is 600bar-1000bar, and cycle-index is 2 ~ 5 times, obtains the composite nerve amide lipid body of appearance transparent.
The application of composite nerve amide lipid body in cosmetics described in described composite nerve amide lipid body or claim 5 prepared by technique.
Cholesterol as described herein, it belongs to horny layer composition.
Salicyloyl phytosphingosine as described herein, it is by reinventing the connection of corium and epidermis, and produce collagen protein in papillary layer of corium induction, carry out glabrous skin, and alleviate the wrinkle that skin produces in natural aging and photo aging process, the sheath amine 01 derivatives of unique bionics skin, has excellent anti-aging properties.
Ceramide VI (Cer AP) as described herein, it, by promoting the metabolism of old useless cutin, allows skin surface become smoothly tender.
Ceramide IIIB as described herein (ceramide 3 B), it is flexible and help to alleviate skin condition susceptible that it can make skin present water profit.
Hydrogenated phospholipid as described herein, it is as the carrier of parcel.
The present invention has following beneficial effect:
(1) the composite nerve amide lipid body stability of this project is high, water dispersible good, good biocompatibility, can under normal temperature condition with cosmetic formulations any interworking;
(2) this preparation method is simply controlled, and repeatability better.
Hydrogenated phospholipid is introduced in this case, coordinates polyhydric alcohol, adopts high pressure homogenize, is wrapped in same system, does not conform to multiple insoluble ceramide ethanol, do not conform to antiseptic, can be miscible with arbitrary proportion with water, improves absorption and the bioavailability of active matter.
Detailed description of the invention
The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.
Embodiment 1: the preparation technology of composite nerve amide lipid body, its technological process is: take 50g glycerol, 0.2g cholesterol, 0.2g salicyloyl phytosphingosine, 0.2g ceramide VI, 0.2g ceramide IIIB, 1g hydrogenated phospholipid 90H, 2g octyl dodecanol, 5g dipropylene glycol, stir under 70 DEG C of conditions and form clear solution, add 41.2g water to stir, mixed liquor is circulated 5 times by high pressure homogenizer under 600bar pressure condition, obtain transparent composite nerve amide lipid body, this composite nerve amide lipid body measures its particle diameter through laser particle analyzer and is about 450nm.
By previous process gained composite nerve amide lipid body under normal temperature condition with cosmetic formulations any interworking, preferably result of use can be obtained.
Embodiment 2: the preparation technology of composite nerve amide lipid body, its technological process is: take 60g glycerol, 0.5g cholesterol, 0.5g salicyloyl phytosphingosine, 0.5g ceramide VI, 0.5g ceramide IIIB, 3g hydrogenated phospholipid 75H, 5g octyl dodecanol, 15g dipropylene glycol, stir under 80 DEG C of conditions and form clear solution, add 15g water to stir, mixed liquor is circulated 3 times by high pressure homogenizer under 800bar pressure condition, obtain transparent composite nerve amide lipid body, this composite nerve amide lipid body measures its particle diameter through laser particle analyzer and is about 430nm.The composite nerve amide lipid body that the program obtains can carry out any interworking with cosmetics, the cosmetics described in this, and it can adopt the existing any cosmetic type in market, and the composite nerve amide lipid body only needing adding portion this case to prepare.
Embodiment 3: the preparation technology of composite nerve amide lipid body, its technological process is: take 30g glycerol, 0.5g cholesterol, 0.5g salicyloyl phytosphingosine, 0.5g ceramide VI, 0.5g ceramide IIIB, 3g hydrogenated phospholipid 95H, 5g octyl dodecanol, 20g dipropylene glycol, stir under 90 DEG C of conditions and form clear solution, add 40g water to stir, mixed liquor is circulated 2 times by high pressure homogenizer under 1000bar pressure condition, obtain transparent composite nerve amide lipid body, this composite nerve amide lipid body measures its particle diameter through laser particle analyzer and is about 350nm.
The composite nerve amide lipid body stability of this project is high, water dispersible good, good biocompatibility, can under normal temperature condition with cosmetic formulations any interworking; This preparation method is simply controlled, and repeatability better.
The foregoing is only the preferred embodiment of the present invention, protection scope of the present invention is not limited in above-mentioned embodiment, and every technical scheme belonging to the principle of the invention all belongs to protection scope of the present invention.For a person skilled in the art, the some improvement carried out under the prerequisite not departing from principle of the present invention, these improvement also should be considered as protection scope of the present invention.
Claims (6)
1. composite nerve amide lipid body, is characterized in that, it is made up of following component by weight percentage:
Glycerol 10% ~ 60%;
Cholesterol 0.1% ~ 0.5%;
Salicyloyl phytosphingosine 0.1% ~ 0.5%;
Ceramide VI 0.1% ~ 0.5%;
Ceramide IIIB 0.1% ~ 0.6%;
Hydrogenated phospholipid 0.5% ~ 3%;
Octyl dodecanol 1% ~ 5%;
Dipropylene glycol 1% ~ 20%;
Surplus is water.
2. composite nerve amide lipid body according to claim 1, it is characterized in that, it is made up of following component by weight percentage:
Glycerol 50%;
Cholesterol 0.2%;
Salicyloyl phytosphingosine 0.2%;
Ceramide VI 0.2%;
Ceramide IIIB 0.2%;
Hydrogenated phospholipid 1%;
Octyl dodecanol 2%;
Dipropylene glycol 5%;
Surplus is water.
3. composite nerve amide lipid body according to claim 1, it is characterized in that, it is made up of following component by weight percentage:
Glycerol 60%;
Cholesterol 0.5%;
Salicyloyl phytosphingosine 0.5%;
Ceramide VI 0.5%;
Ceramide IIIB 0.5%;
Hydrogenated phospholipid 3%;
Octyl dodecanol 5%;
Dipropylene glycol 15%;
Surplus is water.
4. composite nerve amide lipid body according to claim 1, it is characterized in that, it is made up of following component by weight percentage:
Glycerol 30%;
Cholesterol 0.5%;
Salicyloyl phytosphingosine 0.5%;
Ceramide VI 0.5%;
Ceramide IIIB 0.5%;
Hydrogenated phospholipid 3%;
Octyl dodecanol 5%;
Dipropylene glycol 20%;
Surplus is water.
5. prepare as arbitrary in Claims 1 to 4 as described in the technique of composite nerve amide lipid body, it is characterized in that, comprise the steps:
S1, by glycerol, cholesterol, salicyloyl phytosphingosine, ceramide VI, ceramide IIIB, hydrogenated phospholipid, octyl dodecanol, dipropylene glycol mix homogeneously under 70 ~ 90 DEG C of conditions, obtain mixed solution A;
S2, add water to mixed solution A, stir, by high pressure homogenizer process, wherein, high pressure homogenize pressure is 600bar-1000bar, and cycle-index is 2 ~ 5 times, obtains the composite nerve amide lipid body of appearance transparent.
6. the application of composite nerve amide lipid body in cosmetics according to the arbitrary described composite nerve amide lipid body of Claims 1 to 4 or claim 5 prepared by technique.
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| CN201410787026.5A CN104546516A (en) | 2014-12-09 | 2014-12-09 | Preparation process and application of compound ceramide liposome |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105496886A (en) * | 2015-12-29 | 2016-04-20 | 苏州工业园区安诺科斯化妆品研发有限公司 | Phytosphingosine skin moisturizer |
| CN106691889A (en) * | 2015-11-12 | 2017-05-24 | 武汉百思凯瑞纳米科技有限公司 | High skin retention ceramide nano composition, and preparation method and applications thereof |
| CN106963665A (en) * | 2017-04-06 | 2017-07-21 | 湖南御家化妆品制造有限公司 | One group of four-dimensional moisturizing is combined and its is preparing the application of moisture-keeping cosmetics |
| CN107028810A (en) * | 2017-04-06 | 2017-08-11 | 湖南御家化妆品制造有限公司 | A kind of transdermal moisturizing combination and the application in cosmetics are prepared |
| CN107115217A (en) * | 2017-05-05 | 2017-09-01 | 湖南御家化妆品制造有限公司 | Ceramide liposome and application thereof in preparation of intelligent moisturizing cosmetics |
| CN109453043A (en) * | 2018-12-13 | 2019-03-12 | 诺斯贝尔化妆品股份有限公司 | A kind of nanoemulsions having good stability |
| CN110251416A (en) * | 2019-07-05 | 2019-09-20 | 中山中研化妆品有限公司 | A kind of Ceramide Complex and preparation method thereof |
| CN111743807A (en) * | 2020-08-03 | 2020-10-09 | 上海奥利实业有限公司 | Water-oil insoluble transparent ceramide aqueous solution and preparation method thereof |
| CN112336649A (en) * | 2020-11-09 | 2021-02-09 | 江南大学 | Preparation method and product of skin co-permeation carrier of ceramide and fat-soluble active substance |
| CN113384483A (en) * | 2020-03-10 | 2021-09-14 | 盈妆生物科技(上海)有限公司 | Composition for improving skin elasticity and delaying aging and preparation method thereof |
| CN113456525A (en) * | 2021-05-25 | 2021-10-01 | 上海达尔威生物技术研发有限公司 | Polysaccharide liposome containing hyaluronic acid, hydroxypropyl tetrahydropyrane triol and phytosphingosine derivative and preparation method thereof |
| CN113662879A (en) * | 2021-08-31 | 2021-11-19 | 珀莱雅化妆品股份有限公司 | Salt-tolerant ceramide liposome with skin repairing effect and preparation method thereof |
| CN114028260A (en) * | 2021-11-09 | 2022-02-11 | 上海药坦药物研究开发有限公司 | Ceramide E emulsifier, preparation method thereof and application thereof in cosmetics |
| CN114569486A (en) * | 2021-11-12 | 2022-06-03 | 广州中康医药科技有限公司 | Easily-absorbed skin repair liposome and preparation method thereof |
| CN115429713A (en) * | 2022-10-12 | 2022-12-06 | 广州菲科日用化工有限公司 | Moisturizing, repairing and anti-aging composition containing ceramide and preparation method thereof |
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Cited By (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106691889B (en) * | 2015-11-12 | 2019-12-20 | 武汉百思凯瑞生物科技有限公司 | High-skin-retention ceramide nano composition and preparation method and application thereof |
| CN106691889A (en) * | 2015-11-12 | 2017-05-24 | 武汉百思凯瑞纳米科技有限公司 | High skin retention ceramide nano composition, and preparation method and applications thereof |
| CN105496886A (en) * | 2015-12-29 | 2016-04-20 | 苏州工业园区安诺科斯化妆品研发有限公司 | Phytosphingosine skin moisturizer |
| CN106963665A (en) * | 2017-04-06 | 2017-07-21 | 湖南御家化妆品制造有限公司 | One group of four-dimensional moisturizing is combined and its is preparing the application of moisture-keeping cosmetics |
| CN107028810A (en) * | 2017-04-06 | 2017-08-11 | 湖南御家化妆品制造有限公司 | A kind of transdermal moisturizing combination and the application in cosmetics are prepared |
| CN107028810B (en) * | 2017-04-06 | 2018-03-27 | 湖南御家化妆品制造有限公司 | A kind of transdermal moisturizing combination and the application in cosmetics are prepared |
| WO2018184516A1 (en) * | 2017-04-06 | 2018-10-11 | 湖南御家化妆品制造有限公司 | Moisturizing composition and application thereof in preparation of moisturizing cosmetic product |
| US10537512B2 (en) | 2017-04-06 | 2020-01-21 | Hunan Yujia Cosmetics Manufacturing Co., Ltd. | Moisturizing composition and application thereof in preparation of moisturizing cosmetic product |
| CN107115217B (en) * | 2017-05-05 | 2020-10-30 | 湖南御家化妆品制造有限公司 | Ceramide liposome and application thereof in preparation of moisturizing cosmetics |
| CN107115217A (en) * | 2017-05-05 | 2017-09-01 | 湖南御家化妆品制造有限公司 | Ceramide liposome and application thereof in preparation of intelligent moisturizing cosmetics |
| CN109453043B (en) * | 2018-12-13 | 2021-09-28 | 诺斯贝尔化妆品股份有限公司 | Nano emulsion with good stability |
| CN109453043A (en) * | 2018-12-13 | 2019-03-12 | 诺斯贝尔化妆品股份有限公司 | A kind of nanoemulsions having good stability |
| CN110251416A (en) * | 2019-07-05 | 2019-09-20 | 中山中研化妆品有限公司 | A kind of Ceramide Complex and preparation method thereof |
| CN113384483A (en) * | 2020-03-10 | 2021-09-14 | 盈妆生物科技(上海)有限公司 | Composition for improving skin elasticity and delaying aging and preparation method thereof |
| CN111743807A (en) * | 2020-08-03 | 2020-10-09 | 上海奥利实业有限公司 | Water-oil insoluble transparent ceramide aqueous solution and preparation method thereof |
| CN112336649B (en) * | 2020-11-09 | 2021-10-22 | 江南大学 | Preparation method and product of skin co-permeation carrier of ceramide and fat-soluble active substance |
| CN112336649A (en) * | 2020-11-09 | 2021-02-09 | 江南大学 | Preparation method and product of skin co-permeation carrier of ceramide and fat-soluble active substance |
| CN113456525A (en) * | 2021-05-25 | 2021-10-01 | 上海达尔威生物技术研发有限公司 | Polysaccharide liposome containing hyaluronic acid, hydroxypropyl tetrahydropyrane triol and phytosphingosine derivative and preparation method thereof |
| CN113662879A (en) * | 2021-08-31 | 2021-11-19 | 珀莱雅化妆品股份有限公司 | Salt-tolerant ceramide liposome with skin repairing effect and preparation method thereof |
| CN113662879B (en) * | 2021-08-31 | 2023-03-03 | 珀莱雅化妆品股份有限公司 | Salt-tolerant ceramide liposome with skin repairing effect and preparation method thereof |
| CN114028260A (en) * | 2021-11-09 | 2022-02-11 | 上海药坦药物研究开发有限公司 | Ceramide E emulsifier, preparation method thereof and application thereof in cosmetics |
| CN114028260B (en) * | 2021-11-09 | 2023-12-08 | 上海药坦药物研究开发有限公司 | Ceramide E emulsifier, preparation method thereof and application thereof in cosmetics |
| CN114569486A (en) * | 2021-11-12 | 2022-06-03 | 广州中康医药科技有限公司 | Easily-absorbed skin repair liposome and preparation method thereof |
| CN114569486B (en) * | 2021-11-12 | 2023-08-18 | 广州中康医药科技有限公司 | Easily-absorbed skin repair liposome and preparation method thereof |
| CN115429713A (en) * | 2022-10-12 | 2022-12-06 | 广州菲科日用化工有限公司 | Moisturizing, repairing and anti-aging composition containing ceramide and preparation method thereof |
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