CN115969762A - Long-acting high-efficiency moisturizing supermolecule liposome mask and preparation method thereof - Google Patents
Long-acting high-efficiency moisturizing supermolecule liposome mask and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a long-acting high-efficiency moisturizing supramolecular liposome facial mask and a preparation method thereof, wherein the supramolecular liposome facial mask comprises the following components: 1-10 parts of supramolecular solvent, 1-30 parts of grease, 0.5-5 parts of emulsifier, 5-20 parts of active substance, 0.1-2 parts of thickener, 0.1-0.5 part of antioxidant, 0.5-2.0 parts of preservative, 2-10 parts of humectant and other water-soluble solvent; the invention uses supermolecule wrapping technology, uses low-amount emulsifier, stably wraps active macromolecules dissolved by a high-content oil system and supermolecule solvent in the microcapsules by a high-energy emulsification method, and nanocrystallizes common active substance raw materials at the same time, so that the particle diameter of the supermolecule microcapsule mask aqueous solution prepared by the method is measured to reach a nanometer range, and experiments prove that the transdermal absorption of the supermolecule microcapsule mask aqueous solution is remarkably improved by 2-3 times, the transdermal loss of water is remarkably reduced, deep nourishing is realized, and the supermolecule microcapsule mask aqueous solution has long-acting and high-efficiency moisture-preserving effects.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a long-acting high-efficiency moisturizing supermolecule liposome mask and a preparation method thereof.
Background
According to research and analysis, consumers in different age groups have different functional requirements on the mask, but on the premise of meeting other effects, the tendency of the consumers is based on moisturizing and water supplementing, and then other effects are exerted, so that the basis of moisturizing and water supplementing is also important, and the mask is worthy of deep research.
Most of the skin care products on the market at present start from the aspect of regulating skin microecology, only act on epidermal cells, and the supply of nutrient substances and the discharge of metabolites of human skin are mainly carried out by leading interstitial fluid in dermis to pass through a basement membrane back and forth, which only acts on epidermis but cannot achieve the aim. The basement membrane is positioned between the epidermis and the dermis, is an important structure for connecting the epidermis and the dermis, and is an essential factor for realizing targeted and accurate skin care, so that the most important skin care is transdermal.
The water content of the general skin-care emulsion mask is between 60% and 80%, after the skin-care emulsion mask is applied on the skin, the water in the cream body can be quickly evaporated to reach a balance process in a short time, and the water content on the skin is determined by the characteristics of grease and a humectant in the formula. However, the facial mask prepared by the supermolecule liposome technology contains oil, a humectant and an active substance, can achieve ultramicro particle size and efficient skin penetration through the technology, achieves the effects that a corium layer moisturizes the skin, adjusts the water-oil balance of the face, and really achieves effective and efficient moisturizing and skin care.
With the wide application of the micro-emulsification technology in the field of cosmetics, more and more cosmetics are developed by adopting the micro-emulsification technology. Most of the common micro-emulsion moisturizing masks on the market at present adopt a low-energy method, and the micro-emulsion mask is obtained by emulsifying oil and moisturizing active substances through sufficient emulsifier and then shearing, wherein the particle size of the micro-emulsion mask obtained by the method can only reach the micron level, like some macromolecular moisturizing active substances are not enough to deeply penetrate into the inner layer of the skin to deeply moisturize the skin, the active substances are difficult to absorb, the effect is not ideal, and the cost is relatively high. The active ingredients are wrapped by the supermolecule solvent, the oil is emulsified by the emulsifier with smaller amount and precise proportion, and the liposome facial mask is prepared by a high-energy emulsification method.
The supramolecular eutectic solvent (DESs) is a novel eutectic mixed solvent formed by complexing a Hydrogen Bond Acceptor (HBA) and a Hydrogen Bond Donor (HBD), the DESS and Ionic Liquids (ILS) have similar physical properties, viscosity, refractive index, high conductivity and low surface tension, but compared with IIS, the DESS has the advantages of simplicity in preparation, low toxicity, biodegradability, biocompatibility, recoverability and the like, and is an excellent permeation-promoting green solvent. At present, the supermolecule eutectic solvent is applied to a small amount of micro-lipid vesicle masks of cosmetics, and cannot meet the requirements of long-acting and efficient moisture retention of the cosmetic masks.
Disclosure of Invention
The application aims to provide the long-acting high-efficiency moisturizing supramolecular liposome mask and the preparation method thereof, high-content grease, an antioxidant, a preservative, a humectant and other active ingredients are stably encapsulated in supramolecular solvent liposome, and the high-content grease, the antioxidant, the preservative, the humectant and other active ingredients are applied to the mask, so that the long-acting high-efficiency moisturizing effect is achieved.
The technical scheme adopted by the invention is as follows:
in order to realize the aim, the invention provides a long-acting high-efficiency moisturizing supramolecular liposome facial mask and a preparation method thereof, and the preparation method comprises the following steps:
the method comprises the following steps: sequentially adding 1-10 parts of grease, 0.5-3 parts of emulsifier and 0.1-0.5 part of antioxidant, and mixing and stirring uniformly at the temperature of 55-65 ℃ to obtain phase A;
step two: mixing 5-20 parts of active matter, 1-5 parts of supramolecular solvent and the balance of 90% water, and stirring uniformly to form a phase B;
step three: sequentially adding 0.1-2 parts of thickening agent, 0.5-2.0 parts of preservative, 2-10 parts of humectant and the balance of 10% of water, and uniformly mixing and stirring at 50 ℃ to obtain a phase C;
step four: slowly dripping phase A into phase B while stirring, shearing at 6000rpm for 3min, homogenizing under 600bar, and 4 times; and mixing and adding the phase C into the phase AB after homogenizing, and uniformly stirring to obtain the supermolecular liposome mask solution.
Preferably, the oil is one or more of squalane, chinarue seed oil, camellia oil, olive oil, jojoba oil and shea butter.
Preferably, the emulsifier is any one or more of acrylic acid (ester) copolymer sodium, lecithin, C14-22 alcohol, C12-20 alkyl glucoside, lauryl glucoside, soybean lecithin, steareth-21, behenyl alcohol and PEG-100 stearate.
Preferably, the antioxidant is any one or more of tocopherol acetate, TBHQ, tea polyphenol, propyl gallate and ascorbyl palmitate.
Preferably, the supramolecular solvent is one or more of betaine propylene glycol, betaine malic acid, L-carnitine citric acid, glycerol betaine, lactic acid glucose, citric acid glucose, matrine coconut oil and matrine camellia oil.
Preferably, the thickening agent is one or more of carbomer, xanthan gum, ammonium acryloyldimethyl taurate/VP copolymer and sodium acrylate copolymer.
Preferably, the preservative is one or more of polyhydric alcohol, p-hydroxyacetophenone, chlorphenesin, dibutyl octyl sebacate, benzyl salicylate and butoxy diglycol.
Preferably, the active substance is one or more of betaine, trehalose, glycerol glucoside, sodium hyaluronate, erythritol, panthenol, royal jelly, oat glucan, sodium pyrrolidone carboxylate, maltitol, urea, chitin, collagen, sodium hyaluronate, and ceramide.
Preferably, the humectant is one or more of 1,3-butanediol, 1,3-propylene glycol, glycerol, and dipropylene glycol.
Preferably, the long-acting high-efficiency moisturizing supramolecular liposome mask and the preparation method thereof are characterized in that a high-pressure homogenization method is adopted in the preparation method.
The invention has the beneficial effects that: the invention relates to a long-acting high-efficiency moisturizing supermolecule liposome mask and a preparation method thereof.A supermolecule solvent is used for dissolving a moisturizing active substance, and when a supermolecule liposome is formed, the active substance and grease are effectively wrapped in the liposome to assist in permeation promotion, and the particle size of a final product exists in a nano-level liposome form;
by adopting the technical scheme, the method has the following advantages:
1. the green supermolecule solvent is adopted to assist permeation-promoting active macromolecules, so that active material is efficient and economical, is easier to be absorbed by skin, and the utilization rate of the material is greatly improved;
2. high-efficiency permeation, and the skin is protected by directly reaching the dermis layer;
3. the long-acting slow release is realized, and the moisturizing effect is prolonged;
4. the skin feel is fine, smooth and moist, and is more skin-friendly;
the particle size of the supermolecule liposome facial mask aqueous solution prepared by the method is measured to reach the nano range, high-content grease, antioxidant, preservative, humectant and other active ingredients are stably encapsulated in supermolecule solvent liposome, and the supermolecule solvent liposome is applied to the facial mask.
Drawings
FIG. 1 is a sample diagram of a long-acting high-efficiency moisturizing supramolecular liposome mask fluid;
FIG. 2 is a Bundale effect diagram of the long-acting high-efficiency moisturizing supramolecular liposome mask liquid immersion;
FIG. 3 is a particle size diagram of a long-acting high-efficiency moisturizing supramolecular liposome mask fluid;
FIG. 4 is a graph showing the variation of particle size in the stability of a long-acting, high-efficiency, moisturizing supramolecular liposome mask fluid;
FIG. 5 is a potential diagram of a long-acting high-efficiency moisturizing supramolecular liposome mask fluid;
FIG. 6 is a microscopic view of a long-acting, high-efficiency, moisturizing supramolecular liposome mask fluid;
FIG. 7 is a comparison graph of a long-acting high-efficiency moisturizing supramolecular liposome mask liquid and a common emulsion mask and a transdermal test;
FIG. 8 is a data plot of the results of patch irritation in accordance with the present invention;
FIG. 9 is a skin feel experience level chart of the eutectic supramolecular liposome mask of the invention;
FIG. 10 is a skin feel experience level chart of a common microemulsion mask;
FIG. 11 is a graph showing the results of the average change in the water content of the horny layer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
As shown in fig. 1 to 11, the present invention provides a long-acting high-efficiency moisturizing supramolecular liposome facial mask and a preparation method thereof, and the specific embodiments and applications thereof are as follows:
example 1
The long-acting high-efficiency moisturizing supramolecular liposome mask liquid comprises the following raw materials in percentage by mass as shown in the following table 1:
TABLE 1
The preparation steps are as follows:
the method comprises the following steps: sequentially adding the phase A, and mixing and stirring at 55-65 deg.C to obtain phase A;
step two: mixing and stirring the phase B and the balance of 90% of water at the temperature of 55-65 ℃ to form a phase B;
step three: sequentially adding the phase C and the balance of 10% of water, and uniformly mixing and stirring at 50 ℃ to obtain a phase C;
step four: slowly dripping the phase A into the phase B, stirring while adding, shearing at 6000rpm for 3min, homogenizing at 600bar, and 4 times; and mixing and adding the phase C into the phase AB after homogenizing, and uniformly stirring to obtain the supermolecular liposome mask solution.
Example 2
The long-acting high-efficiency moisturizing supramolecular liposome mask liquid comprises the following raw materials in percentage by mass as shown in the following table 2:
TABLE 2
The preparation method comprises the following steps:
the method comprises the following steps: sequentially adding the phase A, and mixing and stirring at 55-65 deg.C to obtain phase A;
step two: mixing and stirring the phase B and the balance of 90% of water at the temperature of 55-65 ℃ to form a phase B;
step three: slowly dripping the phase A into the phase B, stirring while adding, shearing at 6000rpm for 3min, homogenizing at 600bar, and 4 times; and after homogenizing, mixing the phase C and adding the mixture into the phase AB, and shearing the mixture uniformly to finally obtain the supermolecular liposome mask solution.
Example 3
The long-acting high-efficiency moisturizing supramolecular liposome mask liquid comprises the following raw materials in percentage by mass as shown in the following table 3:
TABLE 3
The preparation method comprises the following steps:
the method comprises the following steps: sequentially adding the phase A, and mixing and stirring at 55-65 deg.C to obtain phase A;
step two: mixing and stirring the phase B and the balance of 90% of water at the temperature of 55-65 ℃ to form a phase B;
step three: sequentially adding the phase C and the balance of 10% of water, and uniformly mixing and stirring at 50 ℃ to obtain a phase C;
step four: slowly dripping phase A into phase B while stirring, shearing at 6000rpm for 3min, homogenizing under 600bar, and 4 times; and mixing and adding the phase C into the phase AB after homogenizing, and uniformly stirring to obtain the supermolecular liposome mask solution.
Comparative example: common microemulsion mask
The general micro-emulsion mask liquid comprises the following raw materials in percentage by mass as shown in the following table 4:
TABLE 4
Preparation procedure
The method comprises the following steps: adding the phase A in sequence, heating to 80 ℃, and stirring to dissolve completely;
step two: adding the phase B in turn, heating and stirring to 80 ℃, and stirring and dissolving completely;
step three: slowly adding the phase A into the phase B for shearing and dispersing, and cooling to room temperature to obtain the common micro-emulsion mask liquid.
Product effect verification
Test example 1: appearance contrast test
Comparing the supramolecular liposome mask solution with a common microemulsion mask solution, as shown in figures 1 and 2, it can be seen that the supramolecular liposome mask solution is more delicate and bluish in appearance state, and the common microemulsion mask solution is watery; when the supermolecule liposome facial mask is dropped into water, the supermolecule liposome facial mask is transparent and light blue, the particle size is uniform, the common microemulsion is in a fuzzy suspension state, the particle size is different, and the Tyndall effect difference is obvious.
Test example 2: stability test
After 3 months of accelerated stability observation, the particle size is basically unchanged and is relatively stable. As shown in fig. 3, 4, 5.
Test example 3: microscopic state diagram of supramolecular encapsulation
The micro lipid vesicle liquid drop after eutectic supermolecule wrapping is microcosmically in a convex spherical shape, a thin lipid shell is arranged on the periphery of the micro lipid vesicle liquid drop, and the content is oil drops and active matters. The appearance is as in fig. 6.
Test example 4: in vitro penetration test
The pretreated fresh pigskin with uniform thickness is fixed between a diffusion pool and a receiving pool, and the liquid level of the receiving liquid is contacted with the lower layer of the skin. Starting an electromagnetic stirrer and a constant-temperature water bath, keeping a constant speed (the stirring speed is 300 rpm) and a constant temperature (37 ℃), taking a common micro-emulsion mask liquid as a control, taking a sample as the supermolecule micro-lipid vesicle mask liquid in the example 1, taking a receiving liquid in the pool as physiological saline, taking pigskin samples respectively 0.5, 1, 2 and 4 hours after the diffusion experiment starts, and shearing and extracting. The retention of the intradermal active in each sample was measured intradermally (using tocopheryl acetate as the test target). The test results are shown in FIG. 7.
The results in fig. 7 show that the permeation promoting effect of the supramolecular liposome mask solution is improved by 2 times compared with that of the common microemulsion, and the trend shows a slow permeation process.
Efficacy verification
Test example 5: product safety evaluation-patch
(1) Test samples: supramolecular liposome mask solutions prepared in example 1.
(2) The test method comprises the following steps: 33 healthy volunteers are selected, the age is 20-60 years, the test subjects meet the volunteer selection standard, no history of allergic dermatitis exists, and no irritant product is used in the previous month.
About 0.020-0.025 ml of the test sample is taken to be coated in a small chamber of a spot tester, a special adhesive tape for external application is applied to the back of a testee, the spot tester is removed after 24 hours, if the rest of the sample is slightly wiped off by a wet paper towel, the results are recorded according to the skin reaction grading standard in the technical Specification for cosmetic safety (2015) at 0.5 hour, 24 hours and 48 hours respectively. The identification criteria are shown in table 5:
table 5: identification standard for irritation grade of patch
| Grade of | |
| 0 | Has no irritation and |
| 1 | |
| 2 | |
| 3 | Erythema, pimples, |
| 4 | Severe edema and bulla |
From the results of the closed patch test (as shown in fig. 7), it can be seen that 33 subjects showed no adverse reaction and no symptoms such as erythema, burning sensation, pruritus, etc. to the supramolecular liposome facial mask solution with repairing and soothing effects prepared in example 1 at 0.5 hour, 24 hours, and 48 hours. The supermolecule liposome facial mask is safe and mild to use and has no stimulation to skin.
Test example 6: skin feel evaluation
(1) Test samples:
(1) example 1 supramolecular liposome mask solutions
(2) Control example ordinary microemulsion mask liquid
(2) The test method comprises the following steps: randomly selecting 20 volunteers aged 18-35 years, applying 3ml of each of the test sample and the control sample on the back of the left hand and the right hand, washing after 10min (blind test without informing the type of the sample liquid), and comparing the results of the volunteers in terms of viscosity, absorbance and moisture retention levels with the judgment results shown in fig. 9 and 10.
(3) The criteria are shown in Table 6:
table 6: skin feeling judging grade table
From the results of fig. 9 and 10, it can be seen that 80% of the supramolecular liposome mask liquid is judged to be of grade 4, while 60% of the ordinary microemulsion mask liquid is judged to be of grade 2, i.e. the supramolecular liposome mask disclosed by the invention has a refreshing skin feel, is absorbed quickly and is moistened after washing, and most of the ordinary microemulsion mask feels that the absorption is slow overall and the feeling after washing is general. Therefore, compared with the common micro-emulsion mask, the supermolecular micro-lipid vesicle mask is refreshing, moisturizes and absorbs quickly, and the skin feel is popular with the public.
Test example 7: skin moisturizing Effect test-Water content of stratum corneum
The moisturizing effect detection, namely the skin cuticle water content detection, is carried out according to QB/T4256-2011 'evaluation guideline for moisturizing effect of cosmetics'.
(1) Test samples:
(1) example 1 supramolecular liposome mask (Combo mask)
(2) Control example ordinary microemulsion mask (matching mask cloth)
(2) The test method comprises the following steps:
randomly selecting 26+26 (52) volunteers at age of 18-50 years, cleaning skin, applying the facial mask on face, taking down after 15-25 minutes, and lightly tapping and absorbing the surplus facial mask liquid (feeling no irritation or itching on eyes and whole face); the water content of the stratum corneum of the skin of the sample group and the control group was measured for 0min (before applying the mask), 30min (after removing the mask), 90min (after removing the mask), 4h (after removing the mask), and 6h (after removing the mask) for 26 persons, respectively, and the statistical data is shown in fig. 11.
From the results shown in fig. 11, it can be seen that the water content of the facial cutin of the supramolecular liposome facial mask of the invention is significantly higher than that of the ordinary microemulsion facial mask, and the water content of the facial cutin of the ordinary microemulsion facial mask test person returns to about the initial value by 6 hours, while the supramolecular liposome facial mask is still significantly higher than the initial value. In addition, according to the change trend of water, the water loss of the supramolecular liposome facial mask is slower, the long-acting high-efficiency moisture retention can be achieved, and the supramolecular liposome facial mask is superior to a common microemulsion facial mask and has an obvious effect.
The invention has the beneficial effects that: the invention relates to a long-acting high-efficiency moisturizing supermolecule liposome mask and a preparation method thereof.A supermolecule solvent is used for dissolving a moisturizing active substance, and when a supermolecule liposome is formed, the active substance and grease are effectively wrapped in the liposome to assist in permeation promotion, and the particle size of a final product exists in a nano-level liposome form;
by adopting the technical scheme, the method has the following advantages:
1. the green supermolecule solvent is adopted to assist permeation-promoting active macromolecules, so that active material is efficient and economical, is easier to be absorbed by skin, and the utilization rate of the material is greatly improved;
2. high-efficiency permeation, and the skin is protected by directly reaching the dermis layer;
3. the long-acting slow release is realized, and the moisturizing effect is prolonged;
4. the skin feel is fine, smooth and moist, and is more skin-friendly;
the particle size of the supermolecule liposome facial mask aqueous solution prepared by the method is measured to reach the nano range, high-content grease, antioxidant, preservative, humectant and other active ingredients are stably encapsulated in supermolecule solvent liposome, and the supermolecule solvent liposome is applied to the facial mask.
In conclusion, according to the supramolecular solvent supramolecular liposome mask solution and the preparation method thereof provided by the invention, the supramolecular liposome mask solution is obtained by active substances and grease encapsulated by a supramolecular solvent, so that the defect of moisturizing macromolecule application is overcome, high-efficiency permeation is realized, the skin of a dermis layer is effectively protected, and the moisturizing effect is as long as 6 hours along with the long-acting slow-release effect; on the aspect of skin feel, the supermolecular liposome facial mask disclosed by the invention is fine and smooth in skin feel and is more popular with consumers. In addition, after the basic effects of high-efficiency moisture retention are achieved, other active substances are added on the basis of the process formula to prepare the facial mask with various effects, and high-efficiency expression can be achieved.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art; the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being covered by the appended claims and their equivalents.
Claims (10)
1. The long-acting high-efficiency moisturizing supramolecular liposome facial mask is characterized by comprising the following components: 1-10 parts of supramolecular solvent, 1-30 parts of grease, 0.5-5 parts of emulsifier, 5-20 parts of active substance, 0.1-2 parts of thickener, 0.1-0.5 part of antioxidant, 0.5-2.0 parts of preservative, 2-10 parts of humectant and water-soluble solvent.
2. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the supramolecular solvent is one or more selected from betaine propylene glycol, betaine malic acid, l-carnitine citric acid, glycerol betaine, glucose lactate, glucose citrate, matrine coconut oil, matrine camellia oil.
3. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the emulsifier is one or more of soybean lecithin, sodium acrylate copolymer, lecithin, C12-20 alkyl glucoside, lauryl glucoside, steareth-21, behenyl alcohol and PEG-100 stearate.
4. The long-acting high-efficiency moisturizing supramolecular liposome facial mask as claimed in claim 1, wherein the antioxidant is one or more of tocopherol acetate, TBHQ, tea polyphenol, propyl gallate and ascorbyl palmitate.
5. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the oil is one or more of squalane, chinquapin seed oil, camellia oil, olive oil, jojoba oil and shea butter.
6. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the thickening agent is one or more of carbomer, xanthan gum, ammonium acryloyldimethyl taurate/VP copolymer and sodium acrylate copolymer.
7. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the preservative is one or more of polyhydric alcohol, p-hydroxyacetophenone, chlorphenesin, dibutyl octyl sebacate, benzyl salicylate, butoxy diglycol.
8. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the active substance is one or more of betaine, trehalose, glycerol glucoside, sodium hyaluronate, erythritol, panthenol, royal jelly, oat glucan, sodium pyrrolidone carboxylate, maltitol, urea, chitin, collagen, sodium hyaluronate, and ceramide.
9. The long-acting high-efficiency moisturizing supramolecular liposome mask as claimed in claim 1, wherein the moisturizing agent is one or more of 1,3-butanediol, 1,3-propanediol, glycerol and dipropylene glycol.
10. A preparation method of a long-acting high-efficiency moisturizing supramolecular liposome mask is characterized by comprising the following steps:
the method comprises the following steps: sequentially adding 1-30 parts of grease, 0.5-5 parts of emulsifier and 0.1-0.5 part of antioxidant, and mixing and stirring uniformly at the temperature of 55-65 ℃ to obtain phase A;
step two: mixing 5-20 parts of active matter, 1-10 parts of supramolecular solvent and the balance of 90% water, and stirring uniformly to form a phase B;
step three: sequentially adding 0.1-2 parts of thickening agent, 0.5-2.0 parts of preservative, 2-10 parts of humectant and the balance of 10% of water, and uniformly mixing and stirring at 50 ℃ to obtain a phase C;
step four: slowly dripping the phase A into the phase B, stirring while adding, shearing at 6000rpm for 3min, homogenizing at 600bar, and 4 times; mixing the phase C and the phase AB after homogenizing, and uniformly stirring to obtain the supermolecular liposome mask solution;
the preparation method in the fourth step adopts a high-pressure homogenization method.
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| CN117643548A (en) * | 2024-01-30 | 2024-03-05 | 深圳杉海创新技术有限公司 | Eutectic solvent, microcapsule, and preparation method and application thereof |
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| CN117643548A (en) * | 2024-01-30 | 2024-03-05 | 深圳杉海创新技术有限公司 | Eutectic solvent, microcapsule, and preparation method and application thereof |
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