CN110755349A

CN110755349A - Allicin shining pigment cream and preparation method thereof

Info

Publication number: CN110755349A
Application number: CN201911185168.3A
Authority: CN
Inventors: 沈衡平
Original assignee: Ou Lulian Biotechnology Guangdong Co Ltd
Current assignee: Ou Lulian Biotechnology Guangdong Co Ltd
Priority date: 2019-11-27
Filing date: 2019-11-27
Publication date: 2020-02-07

Abstract

The invention discloses an allicin shining pigment cream which is prepared from the following raw materials in parts by weight: 1-2 of A phase, 13-15 of A1 phase, 82-85 of B phase, 1.8-3.2 of B1 phase, 1.6-2.6 of C phase and 0.2-0.5 of D phase; phase A: an emulsifier complex; phase A1: an antioxidant compound; phase B: a humectant complex; b1 phase: garlic extract solution; and C phase: a preservative complex; phase D: an emollient; the essence cream has the effects of moisturizing, sun screening, ultraviolet resistance, aging resistance, oxidation resistance, sterilization, skin degreasing prevention and collagen supplement, can protect the skin, delay the skin aging, improve the skin health and provide continuous power for resisting the skin aging.

Description

Allicin shining pigment cream and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to allicin brightening cream.

Background

Skin aging is a progressive physiological process and also a result of the combined action of various factors such as heredity, environment, psychology and the like. With the improvement of living standard of people, the functional requirements on skin care products are higher and higher, and skin care products with anti-aging effect are also in the endlessly. The essence cream is a skin care product added with concentrated high-nutrition components, and has the effects of resisting aging, resisting wrinkles, tightening, moisturizing, whitening and the like according to the pertinence of the formula; the essence is one of skin care products for face, contains precious effective components such as plant extract, ceramide, squalane, etc., and has effects of preventing aging, removing wrinkle, keeping moisture, whitening skin, removing macula, etc. The essence is divided into different subdivided products such as essence liquid, essence lotion, essence cream, essence injection and the like, and the essence liquid and the essence cream are two products with the widest application range;

the essence is suitable for oily skin, and the essence cream has good effect on neutral skin. And the concentration of the essence cream is higher. When the weather is dry, the skin is rough, and the essence cream can achieve good conditioning and improving effects.

Allicin is a trithioallyl ether compound, and naturally exists in the bulb of garlic of Liliaceae. Allicin has strong antibacterial and anti-inflammatory effects, and also has effects in removing dandruff, relieving itching, preventing neuralgia, treating mercury poisoning, resisting radiation, resisting oxidation and aging, protecting biological membrane, resisting aging, preventing and treating mosquito bite, and resisting common cold. Experiments show that the product can prevent and treat hepatic fibrosis and is an antioxidant and anti-aging agent. Allicin is not used in the cosmetic field as long as it is used for dietary therapy at present.

Allicin is a tasteless transparent liquid, and can promote skin blood circulation, remove aged cutin of skin, soften skin and enhance its elasticity, and also can be used for preventing sunburn, preventing melanin deposition, removing mottle and whitening skin. Allicin is also rich in selenium, has strong anticancer effect, and selenium plays a role in oxidation resistance in the form of glutathione oxidase, thereby playing a role in protecting the membrane. Allicin contains 17 amino acids. It contains rich minerals, with phosphorus being the highest, and magnesium, calcium, iron, silicon, aluminum, zinc, etc. being the second.

Allicin is currently used only in the fields of medicines and foods, and has not yet been used in the field of cosmetics, and is considered to be applied to the field of cosmetics because it has an effect of promoting blood circulation to human skin.

Therefore, the allicin is applied to the essence cream product in the field of cosmetics, so that the allicin can be well applied.

Disclosure of Invention

The invention aims to provide allicin shining face cream to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

an allicin brightening skin cream is prepared from the following raw materials in parts by weight:

1-2 of A phase, 13-15 of A1 phase, 82-85 of B phase, 1.8-3.2 of B1 phase, 1.6-2.6 of C phase and 0.2-0.5 of D phase;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient.

As a further scheme of the invention: the phase A comprises the following components in parts by weight: 0.5-0.8 of tri (laureth-4) phosphate, 0.2-0.3 of bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane and 0.3-0.5 of caprylic/capric triglyceride.

As a further scheme of the invention: the phase A1 comprises the following components in parts by weight: 2.5-3.5 parts of silicon-treated superfine titanium dioxide, 5-7 parts of squalane, 3-4 parts of isononyl isononanoate, 0.8-0.9 part of titanium dioxide, 0.1-0.15 part of polydimethylsiloxane, 0.08-0.1 part of aluminum oxide and 0.4-0.6 part of sorbitan sesquioleate.

As a further scheme of the invention: the phase B comprises the following components in parts by weight: 72-76 parts of deionized water, 5-7 parts of glycerol, 3-4 parts of methyl propylene glycol, 0.5-0.8 part of hydroxyethyl piperazine ethane sulfonic acid, 1.5-2 parts of acryloyl dimethyl taurate/VP copolymer and 1-2 parts of propylene glycol.

As a further scheme of the invention: the B1 phase comprises the following components in parts by weight: 1-2 parts of deionized water and 0.05-0.07 part of garlic extract.

As a further scheme of the invention: the phase C comprises the following components in parts by weight: 0.1-0.2 part of phenoxyethanol, 0.2-0.3 part of methyl hydroxybenzoate, 0.2-0.3 part of ethylparaben, 0.4-0.5 part of ethylhexylglycerin, 0.1-0.3 part of propylene glycol and 0.08-0.1 part of essence.

As a further scheme of the invention: the emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

A preparation method of allicin glowing element face cream comprises the following steps:

step one, mixing and dispersing the A1 phase, and repeatedly grinding the mixture for 5 times by a three-roll grinder;

step two, mixing and grinding the phase A1, and then adding the phase A into the mixture and uniformly stirring the mixture for later use;

step three, premixing and dispersing the phase D;

step four, adding the phase B into a main pot, stirring at 800rpm, heating to 80 ℃ (the temperature is continuously raised to 85 +/-2 when the residual temperature is maintained), quickly homogenizing (rotating speed of 2400rpm) after heating until the material body is dispersed to be free of agglomerated raw materials, then preserving the heat for 25 minutes to completely dissolve, and cooling (the material body is fine and smooth in appearance and free of particles) after checking that the material body is free of abnormality;

reducing the stirring speed to 600rpm, cooling to 45 ℃, sequentially adding a phase B1, a phase C and a phase D, adding a phase A, increasing the rotating speed to 800rpm after adding each phase, rapidly stirring for 25 minutes, and rapidly homogenizing (rotating speed of 2400rpm) until the material body is fine;

and step five, sampling and detecting, namely observing whether the appearance of the material body is smooth and fine, and packaging the product after the sample reaches the standard to obtain a finished product.

As a further scheme of the invention: the composition is prepared from the following raw materials in parts by weight:

1-2 of A phase, 13-15 of A1 phase, 82-85 of B phase, 1.8-3.2 of B1 phase, 1.6-2.6 of C phase, 0.2-0.5 of D phase and 3-5 of E phase;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient;

phase E: a composition of fish collagen and bone collagen.

Compared with the prior art, the invention has the beneficial effects that:

the tri (laureth-4) phosphate (also known as trilaurin-4 phosphate triester) in the phase A has excellent emulsifying, dispersing, penetrating, wetting, foaming, dirt removing and solubilizing capabilities.

The caprylic/capric triglyceride is clear to light yellow, is high-clear odorless grease, and belongs to the derivatives of palm oil or coconut oil; it is extracted by a thermal fractionation method; because of the compatible characteristics with human skin, the skin care oil is also suitable for oily skin, and pores cannot be blocked; it has non-greasy texture, can be added into cream or lotion to improve extensibility, and has effects of lubricating and softening skin, and has function of filtering ultraviolet light.

The bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane is used as an emollient, an emulsifier and a skin conditioner in cosmetics;

the component in phase A forms a hydrophilic emulsifier which is easy to form oil-in-water (O/W) emulsion. And has the functions of moisturizing and conditioning the skin.

The silicon-treated superfine titanium dioxide in the A1 phase is used as a sun-proof particle surface to coat an inert protective film, so that the photocatalytic activity of the nano sun-proof agent under ultraviolet irradiation is reduced, the generation of free radicals is inhibited, and the effect of instant whitening can be achieved.

The squalane is prepared by hydrogenating squalene extracted from deep-sea shark liver, has good oxidation resistance, can be well compatible with skin, has low allergy and low irritation, and can accelerate the absorption of other active ingredients by skin;

isononyl isononanoate is an excellent emollient ester with good esterifing action but without greasy feeling. It can soften skin, keep skin moist, and protect dry skin.

Sorbitan sesquioleate can be used in a plurality of cosmetics, including skin care products, cleaning products, moisturizing creams, eye color cosmetics and other cosmetics, and is mainly used as an emollient. It is effective in soothing skin and moisturizing skin, and is extracted from sorbitol, which is a moisturizing agent.

Titanium dioxide, polydimethylsiloxane and aluminum oxide form a composition, wherein the surface of the sun-screening particles is coated with an inert protective film, so that the photocatalytic activity of the nano sun-screening agent under ultraviolet irradiation is reduced, and the generation of free radicals is inhibited.

The components in the A1 phase have the effects of moisturizing, sun-screening, ultraviolet resistance, aging resistance, oxidation resistance and instant whitening, and the synergistic effect of the components can resist not only the natural aging of the skin, but also the aging of the skin caused by external influence.

The components of phase B have film-coating effect, can easily form a protective film on the skin surface, also has lubricating effect, and also has moisture-keeping effect under the protective film.

The allicin in the B1 phase is odorless transparent liquid, and can promote skin blood circulation, remove aged cutin of skin, soften skin and enhance its elasticity, and also has effects of preventing sunburn, preventing melanin deposition, removing macula and whitening. Allicin is also rich in selenium, has strong anticancer effect, and selenium plays a role in oxidation resistance in the form of glutathione oxidase, thereby playing a role in protecting the membrane. Allicin contains 17 amino acids. It contains rich minerals, with phosphorus being the highest, and magnesium, calcium, iron, silicon, aluminum, zinc, etc. being the second.

And the cetyl PEG/PPG-10/1 polydimethylsiloxane in the phase D is synthesized by modifying silicone oil through cetyl and polyether, and is used as an emollient which can be retained on the surface of the skin and has a lubricating effect in the stratum corneum. Generally fill the spaces in the skin surface, replace lipids lost in the stratum corneum, reduce flaky skin, improve skin appearance, improve lipid content in the upper layers of skin, prevent excessive skin defatting and dryness;

the collagen in the E phase has strong ability of absorbing water around the environment; when the skin-protecting agent is covered on the skin, the moisture can be prevented from evaporating from the surface, and the moisturizing effect is very obvious. The unique triple-helical structure of the ossein and the hydrophilic group in collagen molecules strengthen the primary hydrodynamic force of the skin, ensure the circulation of water on the surface and the deep layer of the skin, improve lymphatic circulation and ensure that the skin is full and active. The composition of the fish collagen and the ossein is adopted, and the collagen is enabled to be effective through reasonable proportioning, and the increase of the ossein on the viscosity of the essence cream can be reduced.

The essence cream has the effects of moisturizing, sun screening, ultraviolet resistance, aging resistance, oxidation resistance, sterilization, skin degreasing prevention and collagen supplement, can protect the skin, delay the skin aging, improve the skin health and provide continuous power for resisting the skin aging.

Detailed Description

The present application is described in further detail below, and it should be noted that the following detailed description is provided for illustrative purposes only, and is not intended to limit the scope of the present application, which is defined by the appended claims.

Example one

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A1, phase A1, phase B82, phase B1, phase 1.8, phase C1.6, phase D0.2;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient.

The phase A comprises the following components in parts by weight: 0.5 of tri (laureth-4) phosphate, 0.2 of bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane and 0.3 of caprylic/capric triglyceride.

The tri (laureth-4) phosphate (also known as trilaurin-4 phosphate triester) has excellent emulsifying, dispersing, penetrating, wetting, foaming, decontaminating and solubilizing abilities.

The phase A1 comprises the following components in parts by weight: 2.5 parts of silicon-treated superfine titanium dioxide, 5 parts of squalane, 3 parts of isononyl isononanoate, 0.8 part of titanium dioxide, 0.1 part of polydimethylsiloxane, 0.08 part of aluminum oxide and 0.4 part of sorbitan sesquioleate.

The silicon-treated superfine titanium dioxide is used as a sun-screening particle surface to coat an inert protective film, reduces the photocatalytic activity of the nano sun-screening agent under the irradiation of ultraviolet rays, inhibits the generation of free radicals, and can generate the effect of instant whitening.

The phase B comprises the following components in parts by weight: 72-76 parts of deionized water, 5-7 parts of glycerol, 3-4 parts of methyl propylene glycol, 0.5-0.8 part of hydroxyethyl piperazine ethane sulfonic acid, 1.5-2 parts of acryloyl dimethyl taurate/VP copolymer and 1-2 parts of propylene glycol.

The B1 phase comprises the following components in parts by weight: 1-2 parts of deionized water and 0.05-0.07 part of garlic extract.

The phase C comprises the following components in parts by weight: 0.1 part of phenoxyethanol, 0.2 part of methyl hydroxybenzoate, 0.2 part of ethylparaben, 0.4 part of ethylhexyl glycerol, 0.1 part of propylene glycol and 0.08 part of essence.

The C phase components have the functions of antisepsis and sterilization, and the essence can optimize the smell of the essence cream.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

And the cetyl PEG/PPG-10/1 polydimethylsiloxane in the phase D is synthesized by modifying silicone oil through cetyl and polyether, and is used as an emollient which can be retained on the surface of the skin and has a lubricating effect in the stratum corneum. Generally fill the spaces in the skin surface, replace lipids lost in the stratum corneum, reduce flaky skin, improve skin appearance, improve lipid content in the upper layers of skin, prevent excessive skin defatting and dryness.

step three, premixing and dispersing the phase D;

Example two

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A1.4, phase A1, phase B83.5, phase B1, phase C2.1, phase D0.3;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient.

The phase A comprises the following components in parts by weight: 0.7 of tri (laureth-4) phosphate, 0.26 of bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane and 0.4 of caprylic/capric triglyceride.

The phase A1 comprises the following components in parts by weight: 2.9 parts of silicon-treated superfine titanium dioxide, 6 parts of squalane, 3.5 parts of isononyl isononanoate, 0.86 part of titanium dioxide, 0.13 part of polydimethylsiloxane, 0.09 part of aluminum oxide and 0.5 part of sorbitan sesquioleate.

The phase B comprises the following components in parts by weight: deionized water 74, glycerol 6, methyl propylene glycol 3.8, hydroxyethyl piperazine ethane sulfonic acid 0.6, acryloyl dimethyl tauric acid ammonium/VP copolymer 1.8, and propylene glycol 1.5.

The B1 phase comprises the following components in parts by weight: deionized water 1.3, garlic extract 0.06.

The phase C comprises the following components in parts by weight: 0.15 parts of phenoxyethanol, 0.25 parts of methyl hydroxybenzoate, 0.25 parts of ethylparaben, 0.45 parts of ethylhexyl glycerol, 0.16 parts of propylene glycol and 0.09 parts of essence.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

step three, premixing and dispersing the phase D;

EXAMPLE III

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A1.6, phase A1, phase B84, phase B1, phase C2.1, phase D0.4;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient.

The phase A comprises the following components in parts by weight: 0.7 of tri (laureth-4) phosphate, 0.29 of bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane and 0.45 of caprylic/capric triglyceride.

The phase A1 comprises the following components in parts by weight: 3.1 parts of silicon-treated superfine titanium dioxide, 6.5 parts of squalane, 3.9 parts of isononyl isononanoate, 0.86 part of titanium dioxide, 0.14 part of polydimethylsiloxane, 0.09 part of aluminum oxide and 0.5 part of sorbitan sesquioleate.

The phase B comprises the following components in parts by weight: deionized water 75, glycerol 6, methyl propylene glycol 3.9, hydroxyethyl piperazine ethane sulfonic acid 0.7, acryloyl dimethyl tauric acid ammonium/VP copolymer 1.8, and propylene glycol 1.8.

The B1 phase comprises the following components in parts by weight: deionized water 1.8, garlic extract 0.06.

The phase C comprises the following components in parts by weight: 0.18 parts of phenoxyethanol, 0.28 parts of methyl hydroxybenzoate, 0.28 parts of ethylparaben, 0.48 parts of ethylhexyl glycerol, 0.28 parts of propylene glycol and 0.09 parts of essence.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

step three, premixing and dispersing the phase D;

Example four

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A2, phase A1, phase B85, phase B1, phase 3.2, phase C2.6, phase D0.5;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient.

The phase A comprises the following components in parts by weight: 0.8 part of tri (laureth-4) phosphate, 0.3 part of bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane and 0.5 part of caprylic/capric triglyceride.

The phase A1 comprises the following components in parts by weight: 3.5 parts of silicon-treated superfine titanium dioxide, 7 parts of squalane, 4 parts of isononyl isononanoate, 0.9 part of titanium dioxide, 0.15 part of polydimethylsiloxane, 0.1 part of aluminum oxide and 0.6 part of sorbitan sesquioleate.

The phase B comprises the following components in parts by weight: deionized water 76, glycerol 7, methyl propylene glycol 4, hydroxyethyl piperazine ethane sulfonic acid 0.8, acryloyl dimethyl tauric acid ammonium/VP copolymer 2 and propylene glycol 2.

The B1 phase comprises the following components in parts by weight: deionized water 2, garlic extract 0.07.

The phase C comprises the following components in parts by weight: 0.2 parts of phenoxyethanol, 0.3 parts of methyl hydroxybenzoate, 0.3 parts of ethylparaben, 0.5 parts of ethylhexyl glycerol, 0.3 parts of propylene glycol and 0.1 parts of essence.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

step three, premixing and dispersing the phase D;

EXAMPLE five

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A1, phase A1, phase B82, phase B1, phase 1.8, phase C1.6, phase D0.2, phase E3;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient;

phase E: an animal collagen composition.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

The phase E is a composition of fish collagen and ossein, and the mixture ratio of the fish collagen to the bone collagen is as follows: bone collagen ═ 1: 3.

the collagen has strong ability of absorbing water around the environment; when the skin-protecting agent is covered on the skin, the moisture can be prevented from evaporating from the surface, and the moisturizing effect is very obvious. The unique triple-helical structure of the ossein and the hydrophilic group in collagen molecules strengthen the primary hydrodynamic force of the skin, ensure the circulation of water on the surface and the deep layer of the skin, improve lymphatic circulation and ensure that the skin is full and active. The composition of the fish collagen and the ossein is adopted, and the collagen is enabled to be effective through reasonable proportioning, and the increase of the ossein on the viscosity of the essence cream can be reduced.

The fish collagen is mainly extracted from cod, salmon and fresh skin scales by a biological enzyme directional shearing technology.

step three, premixing and dispersing the phase D;

reducing the stirring speed to 600rpm, cooling to 45 ℃, sequentially adding a phase B1, a phase C, a phase D and a phase E, adding a phase A, increasing the rotating speed to 800rpm after adding each phase, quickly stirring for 25 minutes, and quickly homogenizing (rotating speed of 2400rpm) until the material body is fine;

EXAMPLE six

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A1.4, phase A1, phase B83.5, phase B1, phase C2.1, phase D0.3, phase E4;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient;

phase E: an animal collagen composition.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

The phase E is a composition of fish collagen and ossein, and the mixture ratio of the fish collagen to the bone collagen is as follows: bone collagen ═ 1: 5.

step three, premixing and dispersing the phase D;

EXAMPLE seven

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A1.6, phase A1, phase B84, phase B1, phase C2.1, phase D0.4, phase E4.5;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient;

phase E: an animal collagen composition.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

The phase E is a composition of fish collagen and ossein, and the mixture ratio of the fish collagen to the bone collagen is as follows: bone collagen 3: 3.

step three, premixing and dispersing the phase D;

Example eight

An allicin brightening skin cream is prepared from the following raw materials in parts by weight: phase A2, phase A1, phase B85, phase B1, phase 3.2, phase C2.6, phase D0.5, phase E5;

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient;

phase E: an animal collagen composition.

The emollient in phase D was cetyl PEG/PPG-10/1 dimethicone.

The phase E is a composition of fish collagen and ossein, and the mixture ratio of the fish collagen to the bone collagen is as follows: bone collagen 3: 5.

step three, premixing and dispersing the phase D;

Results of the experiment

In the first to eighth embodiments, all the sanitation indexes and the sensory indexes of the product meet the standards of QB/T1857-2013 cream, massage cream and vanishing cream.

The results of the antioxidant activity test and the water loss rate test are shown in the following table:

in the moisture loss test, the average value of the moisture loss (%) in the control area was 41%.

DPPH method determination of antioxidant Activity of essence cream the control test, in which only DPPH ethanol solution was added, showed a radical scavenging rate of 10.2%.

The above experimental results were obtained by the following experimental methods:

experimental method for determining antioxidant activity of essence cream by DPPH (denaturing high pH) method

Antioxidant is any substance that is present at low concentrations to effectively inhibit the oxidation of free radicals, either by acting directly on the free radicals or by indirectly consuming substances that readily form free radicals, preventing further reactions from occurring.

The current research methods for free radical scavengers mainly belong to 2 types, one type is an in vitro model, and the other type is an in vivo model, wherein the DPPH method is the most common method in the in vitro model.

DPPH is also called 1, 1-diphenyl-2-trinitrophenylhydrazine, is a very stable free radical with a nitrogen center, and the stability of DPPH mainly comes from the steric hindrance of 3 benzene rings with resonance stabilization effect, so that unpaired electrons on the nitrogen atom in the middle cannot play the role of electron pairing. Its absolute ethyl alcohol solution is purple, and has maximum absorption at wavelength of 517nm, and its absorbance and concentration are in linear relation. When a radical scavenger is added thereto, DPPH may be combined with or substituted for the radical scavenger, whereby the radical scavenging ability can be evaluated by decreasing the number of radicals, decreasing the absorbance, and decreasing the color of the solution. Namely, the antioxidant capacity was calculated by measuring the DPPH-removing effect of the sample at a wavelength of 517 nm.

Experimental materials: DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine); absolute ethyl alcohol;

an experimental instrument: spectrophotometer

Preparation of DPPH stock solution

Accurately weighing 3.5mg of DPPH reagent, dissolving with absolute ethyl alcohol, quantitatively transferring into a 10mL volumetric flask, fixing the volume to a scale with the absolute ethyl alcohol, taking 2mL to 100mL volumetric flask, shaking up to obtain DPPH stock solution with the concentration of 0.0178mmol/L, and placing in a refrigerator for storage.

Preparation of essence cream solution

Weighing 3.5mg of essence cream (products in the first to eighth embodiments), and adding 100ml of water to obtain essence cream solution.

Measurement of two, DPPH and clearance

Adding 4.0mL of the LDPPH solution and the essence cream solution into a 10mL colorimetric tube in sequence, adding absolute ethyl alcohol to the scale, immediately mixing, measuring a light absorption value (A) at a wavelength of 517nm by using a 1cm cuvette, marking the light absorption value as Ai, then measuring the light absorption value after storing in a greenhouse in a dark place for 30min, marking the light absorption value as Aj, and marking the light absorption value as Ac in a contrast test by using an ethanol solution only added with DPPH. The radical clearance (K) was calculated as follows:

K(％)＝[1-(Ai-Aj)/Ac]*100％

the test was repeated three times, and the average value was taken as the final result.

Medicine preparation: DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine);

the manufacturer: shanghai such as Ji Biotech development Inc. or Beijing Nuo Bo Laide technology Inc.;

and (4) quotation: 380 yuan/bottle; 500 yuan/bottle;

specification: 1 g/bottle;

the content is as follows: 99 percent;

the producing area: imported from Japan.

Method for testing moisture loss rate

An experimental instrument: the model is as follows:

percutaneous water loss (TEWL) determinator for AS-VT100RS

1) Subjects were uniformly cleaned of the inside of the forearm by laboratory test personnel. The subject sits still in a laboratory at a temperature of 21 + -1 deg.C, 50 + -5% RH for at least 20 minutes, during which time water and drink cannot be consumed, the forearm is exposed and remains relaxed;

2) selecting and marking two face areas, namely a product area and a comparison area, wherein the area of each area is 2cm multiplied by 2 cm;

3) testing stratum corneum water content basic value of the face area of the subject;

4) using the test sample in the product area according to the product use requirement;

5) the stratum corneum moisture content measurements of the test subject product and control zones were taken 3h later (fan on side to accelerate moisture loss).

Water loss rate (%) (measured value of stratum corneum moisture content-stratum corneum moisture content base value)/stratum corneum moisture content base value.

Although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.

Claims

1. The allicin shining pigment cream is characterized by being prepared from the following raw materials in parts by weight:

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient.

2. The allicin blaze cream of claim 1, wherein phase a comprises the following components in parts by weight: 0.5-0.8 of tri (laureth-4) phosphate, 0.2-0.3 of bis-PEG/PPG-16/16 PEG/PPG-16/16 polydimethylsiloxane and 0.3-0.5 of caprylic/capric triglyceride.

3. The allicin blaze cream of claim 1, wherein the a1 phase comprises the following components in parts by weight: 2.5-3.5 parts of silicon-treated superfine titanium dioxide, 5-7 parts of squalane, 3-4 parts of isononyl isononanoate, 0.8-0.9 part of titanium dioxide, 0.1-0.15 part of polydimethylsiloxane, 0.08-0.1 part of aluminum oxide and 0.4-0.6 part of sorbitan sesquioleate.

4. The allicin blaze cream of claim 1, wherein phase B comprises the following components in parts by weight: 72-76 parts of deionized water, 5-7 parts of glycerol, 3-4 parts of methyl propylene glycol, 0.5-0.8 part of hydroxyethyl piperazine ethane sulfonic acid, 1.5-2 parts of acryloyl dimethyl taurate/VP copolymer and 1-2 parts of propylene glycol.

5. The allicin blaze cream of claim 1, wherein the B1 phase comprises the following components in parts by weight: 1-2 parts of deionized water and 0.05-0.07 part of garlic extract.

6. The allicin blaze cream of claim 1, wherein the phase C comprises the following components in parts by weight: 0.1-0.2 part of phenoxyethanol, 0.2-0.3 part of methyl hydroxybenzoate, 0.2-0.3 part of ethylparaben, 0.4-0.5 part of ethylhexylglycerin, 0.1-0.3 part of propylene glycol and 0.08-0.1 part of essence.

7. The allicin blaze facial cream of claim 1, wherein the emollient in phase D is cetyl PEG/PPG-10/1 dimethicone.

8. A method of making an allicin blaze cream according to any one of claims 1-7, comprising the steps of:

step three, premixing and dispersing the phase D;

9. The allicin glowing cream of claim 1, which is prepared from the following raw materials in parts by weight:

phase A: an emulsifier complex;

phase A1: an antioxidant compound;

phase B: a humectant complex;

b1 phase: garlic extract solution;

and C phase: a preservative complex;

phase D: an emollient;

phase E: a composition of fish collagen and bone collagen.